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                                                                     Exhibit 4.4



                                  ANTHEM, INC.,

                                                as Issuer


                                       TO

                              THE BANK OF NEW YORK,

                                                as Trustee



                          First Supplemental Indenture



                          Dated as of November 2, 2001




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<PAGE>

     First Supplemental Indenture, dated as of November 2, 2001 (the "First
Supplemental Indenture"), between ANTHEM, INC., a corporation duly organized and
existing under the laws of the State of Indiana, (the "Company"), and THE BANK
OF NEW YORK, a New York banking corporation, as trustee (the "Trustee").

     Whereas, the Company executed and delivered the indenture, dated as of
November 2, 2001 (the "Base Indenture"), to the Trustee to provide for the
future issuance of the Company's subordinated debentures (the "Securities"), to
be issued from time to time in one or more series as might be determined by the
Company under the Base Indenture;

     Whereas, pursuant to the terms of the Base Indenture, the Company desires
to provide for the establishment of a new series of its Securities to be known
as its 5.95% Subordinated Debentures due 2006 (the "Debentures"), the form and
substance of such Debentures and the terms, provisions and conditions thereof to
be set forth as provided in the Base Indenture and this First Supplemental
Indenture (together, the "Indenture"); and

     Whereas, the Company has requested that the Trustee execute and deliver
this First Supplemental Indenture and satisfy all requirements necessary to make
this First Supplemental Indenture a valid instrument in accordance with its
terms, and to make the Debentures, when executed by the Company and
authenticated and delivered by the Trustee, the valid obligations of the Company
and all acts and things necessary have been done and performed to make this
First Supplemental Indenture enforceable in accordance with its terms, and the
execution and delivery of this First Supplemental Indenture has been duly
authorized in all respects:

     Now Therefore, in consideration of the purchase and acceptance of the
Debentures by the Holders thereof, and for the purpose of setting forth, as
provided in the Indenture, the form and substance of the Debentures and the
terms, provisions and conditions thereof, the Company covenants and agrees with
the Trustee as follows:

                                    ARTICLE I

                                   DEFINITIONS

SECTION 1.1.  Definition of Terms.

     Unless otherwise provided herein or unless the context otherwise requires:

      (a) a term defined in the Base Indenture has the same meaning when used in
this First Supplemental Indenture;

      (b) a term defined anywhere in this First Supplemental Indenture has the
same meaning throughout;

      (c) the singular includes the plural and vice versa;

      (d) headings are for convenience of reference only and do not affect
interpretation;





<PAGE>

          (e) the following terms have the meanings given to them in the
Purchase Contract Agreement (as defined below): Failed Remarketing; Last Failed
Remarketing; Normal Units; Purchase Contract Agent; Remarketing Agreement;
Remarketing Date; Remarketing Value; Separate Debentures; Subsequent Remarketing
Date; and Underwriting Agreement.

          (f) the following terms have the meanings given to them in this
Section 1.1(f):

        "Interest Rate" shall have the meaning set forth in Section 2.5.

        "Over-Allotment Option" shall mean the option granted to the
        underwriters pursuant to the Underwriting Agreement to purchase up to an
        additional 600,000 Normal Units.

        "Purchase Contract Agreement" shall mean the Purchase Contract
        Agreement, dated as of November 2, 2001, between the Company and The
        Bank of New York, as purchase contract agent.

        "Reset Agent" means a nationally recognized investment banking firm
        chosen by the Company to determine the Reset Rate.

        "Reset Rate" means the lowest interest rate per annum (rounded to the
     nearest one-thousandth (0.001) of one percent per annum), as determined by
     the Reset Agent, that the Debentures shall bear in order for the Debentures
     to have a market value at the Remarketing Date or any Subsequent
     Remarketing Date, as the case may be, of 100.5% of the Remarketing Value,
     assuming, for this purpose, even if not true, that all of the Debentures
     are held as components of Normal Units and will be remarketed; provided,
     however, that if there has been a Failed Remarketing, the Reset Rate will
     be equal to the Interest Rate until (i) the Debentures are successfully
     remarketed pursuant to the Purchase Contract Agreement and the Remarketing
     Agreement or (ii) if the Last Failed Remarketing shall have occurred, the
     principal of the Debentures is paid or made available for payment.

                                   ARTICLE II

                 GENERAL TERMS AND CONDITIONS OF THE DEBENTURES

SECTION 2.1.  Designation, Principal Amount and Authorized Denomination.

          There is hereby authorized a series of Securities designated the 5.95%
Subordinated Debentures due 2006, limited in aggregate principal amount to
$230,000,000, which amount to be issued shall be as set forth in any Company
Order for the authentication and delivery of Debentures pursuant to the Base
Indenture. The Debentures shall be issuable in denominations of $50 and integral
multiples thereof.

SECTION 2.2.  Maturity.

          The Stated Maturity Date of the Debentures will be November 15, 2006.

                                       2



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SECTION 2.3. Form and Payment.

      (a) The Debentures, on original issuance, shall be issued in the form of
(i) one or more definitive, fully registered Debentures registered initially in
the name of The Bank of New York, as Purchase Contract Agent and (ii) one or
more fully registered Global Debentures registered in the name of The Depository
Trust Company ("DTC"), as Depository, or its nominee, and deposited with the
Registrar, as custodian for DTC, for credit by DTC to the respective accounts of
beneficial owners of the Separate Debentures represented thereby (or such other
accounts as they may direct).

      (b) The principal of and the interest on the Debentures shall be payable
at the Office or Agency of the Company maintained for that purpose; provided,
however, that payment of interest may be made at the option of the Company by
check mailed to the registered Holder at such address as shall appear in the
Register or by wire transfer to an account appropriately designated by the
Holder entitled thereto.

SECTION 2.4. Global Debentures.

      (a) DTC shall serve as the initial Depository for the Global Debentures.

      (b) Unless and until it is exchanged for definitive Debentures in
registered form in accordance with Section 2.11 of the Base Indenture, a Global
Debenture may be transferred, in whole but not in part, only to another nominee
of the Depository, or to a successor Depository selected or approved by the
Company or to a nominee of such successor Depository.

SECTION 2.5. Interest and Interest Rate Reset.

      (a) Each Debenture will bear interest from its Issue Date or from the most
recent Interest Payment Date to which interest has been paid or duly provided
for, as the case may be, initially at the rate of 5.95% per annum (the "Interest
Rate") through and including August 15, 2004, and thereafter at the Reset Rate
determined in accordance with Section 2.5(b) and notified to the Trustee by the
Company, in each case payable (subject to the provisions of Section 2.5(c))
quarterly in arrears on February 15, May 15, August 15 and November 15 of each
year (each, an "Interest Payment Date"), commencing February 15, 2002, until the
principal thereof is paid or made available for payment; provided that any
principal and installment of interest which is overdue shall bear interest (to
the extent that payment of such interest is enforceable under applicable law) at
the Interest Rate through and including August 15, 2004 and at the Reset Rate
thereafter, from the dates such amounts are due until they are paid or made
available for payment, and such interest shall be payable on demand.

      (b) The interest rate on the Debentures will be reset on the Remarketing
Date or any Subsequent Remarketing Date, as the case may be, to the Reset Rate
determined by the Reset Agent (which Reset Rate will become effective from and
after August 16, 2004); provided, however, that if there has been a Failed
Remarketing, the Reset Rate will be equal to the Interest Rate until (i) the
Debentures are successfully remarketed pursuant to the Purchase Contract
Agreement and the Remarketing Agreement or (ii) if

                                       3

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the Last Failed Remarketing shall have occurred, the principal of the Debentures
is paid or made available for payment.

      (c) So long as no Event of Default has occurred and is continuing, the
Company shall have the right at any time, and from time to time, during the term
of the Debentures, to defer payments of interest by extending the interest
payment period of such Debentures for a period not extending, in the aggregate,
beyond the Stated Maturity Date (the "Deferral Period"), during which Deferral
Period no interest shall be due and payable. To the extent permitted by
applicable law, interest, the payment of which has been deferred because of the
extension of the interest payment period pursuant to this Section 2.5(c), will
bear interest thereon at the Interest Rate through and including August 15,
2004, and, subject to paragraph (b) above, at the Reset Rate thereafter,
compounded quarterly for each quarter of the Deferral Period ("Compounded
Interest"). At the end of the Deferral Period, the Company shall pay all
interest accrued and unpaid on the Debentures and Compounded Interest (together,
"Deferred Interest"), which shall be payable to the Holders of the Debentures in
whose names the Debentures are registered in the Register on the first record
date after the end of the Deferral Period. Prior to the termination of any
Deferral Period, the Company may further extend such period, provided that such
period together with all such previous and further extensions thereof shall not
extend beyond the Stated Maturity Date. Upon the termination of any Deferral
Period and the payment of all Deferred Interest then due, the Company may
commence a new Deferral Period, subject to the foregoing requirements. No
interest shall be due and payable during a Deferral Period, except at the end
thereof, but the Company, at its option, may prepay on any Interest Payment Date
all or any portion of the interest accrued during the then elapsed portion of a
Deferral Period. The Company shall give the Trustee written notice of the
Company's election to begin a Deferral Period for the Debentures and any
shortening or extension thereof at least five Business Days prior to the earlier
of (i) the date the interest on such Debentures is payable or (ii) the date the
Company is required to give notice to the New York Stock Exchange or other
applicable self-regulatory organization or to holders of the Debentures of the
record date or the date such interest is payable, but in any event not less than
five Business Days prior to such record date. The Company shall give or cause
the Trustee to give notice at the expense of the Company (a form of which shall
be provided by the Company to the Trustee) of the Company's election to begin a
Deferral Period to the Holders by first class mail, postage prepaid.

      (d) The amount of interest payable for any period will be computed on the
basis of a 360-day year consisting of twelve 30-day months. Except as provided
in the following sentence, the amount of interest payable for any period shorter
than a full quarterly period for which interest is computed will be computed on
the basis of the actual number of days elapsed in such a 90-day period. In the
event that any date on which interest is payable on the Debentures is not a
Business Day, then payment of interest payable on such date will be made on the
next succeeding day which is a Business Day (and without any interest or other
payment in respect of any such delay), except that, if such Business Day is in
the next succeeding calendar year, such payment shall be made on the immediately
preceding Business Day, in each case with the same force and effect as if made
on such date.

      (e) The Debentures do not have the benefit of any sinking fund obligation.

                                       4



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                                  ARTICLE III

                                FORM OF DEBENTURE

SECTION 3.1.   Form of Debenture.

         The Debentures and the Trustee's Certificate of Authentication to be
endorsed thereon are to be substantially in the following forms:

         [IF THE DEBENTURE IS A GLOBAL DEBENTURE, INSERT - This Debenture is a
     Global Debenture within the meaning of the Indenture hereinafter referred
     to and is registered in the name of the Depository or a nominee of the
     Depository. This Debenture is exchangeable for Debentures registered in the
     name of a person other than the Depository or its nominee only in the
     limited circumstances described in the Indenture, and no transfer of this
     Debenture (other than a transfer of this Debenture as a whole by the
     Depository to a nominee of the Depository or by a nominee of the Depository
     to the Depository or another nominee of the Depository) may be registered
     except in limited circumstances.

         Unless this Debenture is presented by an authorized representative of
     The Depository Trust Company (55 Water Street, New York, New York) to the
     issuer or its agent for registration of transfer, exchange or payment, and
     any Debenture issued is registered in the name of Cede & Co. or such other
     name as requested by an authorized representative of The Depository Trust
     Company and any payment hereon is made to Cede & Co., ANY TRANSFER, PLEDGE
     OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY A PERSON IS WRONGFUL since
     the registered owner hereof, Cede & Co., has an interest herein.]

No.

CUSIP No.                                                 $_____________________

                                  ANTHEM, INC.
                      5.95% SUBORDINATED DEBENTURE DUE 2006

         ANTHEM, INC., an Indiana corporation (the "Company", which term
includes any successor corporation under the Indenture hereinafter referred to),
for value received, hereby promises to pay to ___________________, the principal
sum of ______ dollars ($______________) on November 15, 2006 (such date is
hereinafter referred to as the "Stated Maturity Date"), and to pay interest on
said principal sum from November 2, 2001, or from the most recent interest
payment date (each such date, an "Interest Payment Date") to which interest has
been paid or duly provided for, quarterly in arrears (subject to deferral as set
forth herein) on February 15, May 15, August 15 and November 15 of each year,
commencing February 15, 2002, initially at the rate of 5.95% per annum (the
"Interest Rate") through and including August 15, 2004, and at the Reset Rate
thereafter, until the principal hereof is paid or made available for payment;
provided that any principal and installment of interest which is overdue shall
bear interest (to the extent that payment of such interest is enforceable under
applicable law) at the Interest Rate through and including August 15, 2004 and
at the Reset Rate thereafter, from the dates such amounts are due until they are
paid or made available for payment, and such interest shall


                                        5

<PAGE>

be payable on demand; and provided, further, that if there has been a Failed
Remarketing, the Reset Rate will be equal to the Interest Rate until (i) the
Debentures are successfully remarketed pursuant to the Purchase Contract
Agreement and the Remarketing Agreement or (ii) if the Last Failed Remarketing
shall have occurred, the principal of the Debentures is paid or made available
for payment. The amount of interest payable on any Interest Payment Date shall
be computed on the basis of a 360-day year consisting of twelve 30-day months.
In the event that any date on which interest is payable on this Debenture is not
a Business Day, then payment of interest payable on such date will be made on
the next succeeding day that is a Business Day (and without any interest or
other payment in respect of any such delay), except that, if such Business Day
is in the next succeeding calendar year, such payment shall be made on the
immediately preceding Business Day, in each case with the same force and effect
as if made on such date. The interest installment so payable, and punctually
paid or duly provided for, on any Interest Payment Date will, as provided in the
Indenture, be paid to the person in whose name this Debenture is registered at
the close of business on the regular record date for such interest installment,
which as long as any Debentures are represented by a Global Debenture shall be
the close of business on the Business Day next preceding such Interest Payment
Date; provided, however, if pursuant to the terms of the Indenture the
Debentures are no longer represented by a Global Debenture, the Company may
select such regular record date for such interest installment which shall be
more than one Business Day but less than 60 Business Days prior to such Interest
Payment Date. Any such interest installment not punctually paid or duly provided
for shall forthwith cease to be payable to the registered Holders on such
regular record date and may be paid to the Person in whose name this Debenture
is registered at the close of business on a special record date to be fixed by
the Trustee for the payment of such defaulted interest, notice whereof shall be
given to the registered Holders of this series of Debentures not less than 10
days prior to such special record date, or may be paid at any time in any other
lawful manner not inconsistent with the requirements of any securities exchange
on which the Debentures may be listed, and upon such notice as may be required
by such exchange all as more fully provided in the Indenture. The principal of
and the interest on this Debenture shall be payable at the Office or Agency of
the Company maintained for that purpose in any coin or currency of the United
States of America that at the time of payment is legal tender for payment of
public and private debts; provided, however, that payment of interest may be
made at the option of the Company by check mailed to the registered Holder at
such address as shall appear in the Register or by wire transfer to an account
appropriately designated by the Holder entitled thereto.

         So long as no Event of Default has occurred and is continuing, the
Company shall have the right at any time, and from time to time, during the term
of this Debenture, to defer payments of interest by extending the interest
payment period of such Debenture for a period not extending, in the aggregate,
beyond the Stated Maturity Date (the "Deferral Period"), during which Deferral
Period no interest shall be due and payable. To the extent permitted by
applicable law, interest, the payment of which has been deferred because of the
extension of the interest payment period pursuant to the provisions of this
Debenture, will bear interest thereon at the rate of 5.95% through and including
August 15, 2004, and at the Reset Rate thereafter, compounded quarterly for each
quarter of the Deferral Period ("Compounded Interest"). At the end of the
Deferral Period, the Company shall pay all interest accrued and unpaid on this
Debenture and Compounded Interest (together, "Deferred Interest") that shall be
payable to the Holders of this Debenture in whose names this Debenture are
registered in the Register on the first


                                        6

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record date after the end of the Deferral Period. Prior to the termination of
any Deferral Period, the Company may further extend such period, provided that
such period together with all such previous and further extensions thereof shall
not extend beyond the Stated Maturity Date. Upon the termination of any Deferral
Period and the payment of all Deferred Interest then due, the Company may
commence a new Deferral Period, subject to the foregoing requirements. No
interest shall be due and payable during any Deferral Period, except at the end
thereof, but the Company, at its option, may prepay on any Interest Payment Date
all or any portion of the interest accrued during the then elapsed portion of a
Deferral Period. The Company shall give the Trustee written notice of the
Company's election to begin a Deferral Period for this Debenture and any
shortening or extension thereof at least five Business Days prior to the earlier
of (i) the date the interest on such Debenture is payable or (ii) the date the
Company is required to give notice to the New York Stock Exchange or other
applicable self-regulatory organization or to holders of the Debentures of the
record date or the date such interest is payable, but in any event not less than
five Business Days prior to such record date. The Company shall give or cause
the Trustee to give notice at the Company's expense (a form of which shall be
provided by the Company to the Trustee) of the Company's election to begin a
Deferral Period to the Holders by first class mail, postage prepaid.

         The indebtedness evidenced by this Debenture is, to the extent and in
the manner provided in the Indenture, subordinate and subject in right of
payment to the prior payment in full of all Senior Indebtedness of the Company,
and this Debenture is issued subject to such provisions of the Indenture with
respect thereto. Each Holder of this Debenture, by accepting the same, (a)
agrees to and shall be bound by such provisions, (b) authorizes and directs the
Trustee on his behalf to take such action as may be necessary or appropriate to
effectuate the subordination so provided and (c) appoints the Trustee his
attorney-in-fact for any and all such purposes.

         This Debenture shall not be entitled to any benefit under the Indenture
hereinafter referred to, be valid or become obligatory for any purpose until the
Certificate of Authentication hereon shall have been signed by or on behalf of
the Trustee.

         The provisions of this Debenture are continued on the reverse side
hereof and such continued provisions shall for all purposes have the same effect
as though fully set forth at this place.


                                        7

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         In Witness Whereof, the Company has caused this instrument to be
executed.

                                               ANTHEM, INC.


                                               By: _________________________
                                                   Name:
                                                   Title:


Attest:


____________________





                          CERTIFICATE OF AUTHENTICATION

         This is one of the Debentures of the series designated herein and
referred to in the within-mentioned Indenture.

Dated:

                                               THE BANK OF NEW YORK,
                                               as Trustee

                                               By: _________________________
                                                   Authorized Signatory

                                        8

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                         (FORM OF REVERSE OF DEBENTURE)

         This Debenture is one of a duly authorized series of the subordinated
debentures of the Company (herein sometimes referred to as the "Securities"),
specified in the Indenture hereinafter referred to, all issued or to be issued
in one or more series under and pursuant to an Indenture dated as of November 2,
2001 (the "Base Indenture"), duly executed and delivered between the Company and
The Bank of New York, as Trustee (the "Trustee") (such Base Indenture as
supplemented by the First Supplemental Indenture, dated November 2, 2001, the
"Indenture"), to which Indenture and all indentures supplemental thereto
reference is hereby made for a description of the rights, limitations of rights,
obligations, duties and immunities thereunder of the Trustee, the Company and
the Holders of the Securities. By the terms of the Indenture, the Securities are
issuable in series that may vary as to amount, date of maturity, rate of
interest and in other respects as provided in the Indenture. This series of
Securities is limited in aggregate principal amount as specified in said First
Supplemental Indenture.

         The Debentures do not have the benefit of any sinking fund obligation.

         In case an Event of Default, as defined in the Indenture, shall have
occurred and be continuing, the principal of all of the Debentures may be
declared, and upon such declaration shall become, due and payable, in the
manner, with the effect and subject to the conditions provided in the Indenture.

         The Indenture contains provisions permitting the Company and the
Trustee, with the consent of the Holders of not less than a majority in
aggregate principal amount of the Securities of each series affected at the time
outstanding, as defined in the Indenture, to execute supplemental indentures for
the purpose of, among other things, adding any provisions to or changing in any
manner or eliminating any of the provisions of the Indenture or of any
supplemental indenture or of modifying in any manner the rights of the Holders
of the Securities; provided, however, that, among other things, no such
supplemental indenture shall (i) reduce the principal amount thereof, or reduce
the rate or extend the time of payment of interest thereon, or reduce any
premium payable upon the redemption thereof, without the consent of the Holder
of each Security so affected, or (ii) reduce the aforesaid percentage of
Securities, the Holders of which are required to consent to any such
supplemental indenture, without the consent of the Holders of each Security then
outstanding and affected thereby. The Indenture also contains provisions
permitting the Holders of a majority in aggregate principal amount of the
Securities of any series at the time outstanding affected thereby, on behalf of
all of the Holders of the Securities of such series, to waive a Default or Event
of Default with respect to such series, and its consequences, except a Default
or Event of Default in the payment of the principal of or premium, if any, or
interest on any of the Securities of such series or a Default in respect of a
provision that under Section 6.4 of the Base Indenture cannot be amended without
the consent of each holder affected thereby. Any such consent or waiver by the
registered Holder of this Debenture (unless revoked as provided in the
Indenture) shall be conclusive and binding upon such Holder and upon all future
Holders and owners of this Debenture and of any Debenture issued in exchange
herefor or in place hereof (whether by registration of transfer or otherwise),
irrespective of whether or not any notation of such consent or waiver is made
upon this Debenture.

                                       9

<PAGE>

         No reference herein to the Indenture and no provision of this Debenture
or of the Indenture shall alter or impair the obligation of the Company, which
is absolute and unconditional, to pay the principal of and premium, if any, and
interest on this Debenture at the time and place and at the rate and in the
money herein prescribed.

         As provided in the Indenture and subject to certain limitations therein
set forth, this Debenture is transferable by the registered Holder hereof on the
Register of the Company, upon surrender of this Debenture for registration of
transfer at the office or agency of the Trustee in the City of New York and
State of New York accompanied by a written instrument or instruments of transfer
in form satisfactory to the Company or the Trustee duly executed by the
registered Holder hereof or his attorney duly authorized in writing, and
thereupon one or more new Debentures of authorized denominations and for the
same aggregate principal amount and series will be issued to the designated
transferee or transferees. No service charge will be made for any such transfer,
but the Company may require payment of a sum sufficient to cover any tax,
assessment or other governmental charge payable in relation thereto.

         Prior to due presentment for registration of transfer of this
Debenture, the Company, the Trustee, any paying agent and the Registrar may deem
and treat the registered holder hereof as the absolute owner hereof (whether or
not this Debenture shall be overdue and notwithstanding any notice of ownership
or writing hereon made by anyone other than the Registrar) for the purpose of
receiving payment of or on account of the principal hereof and premium, if any,
and interest due hereon and for all other purposes, and neither the Company nor
the Trustee nor any paying agent nor any Registrar shall be affected by any
notice to the contrary.

         No recourse shall be had for the payment of the principal of or the
interest on this Debenture, or for any claim based hereon, or otherwise in
respect hereof, or based on or in respect of the Indenture, against any
incorporator, shareholder, officer or director, past, present or future, as
such, of the Company or of any predecessor or successor corporation, whether by
virtue of any constitution, statute or rule of law, or by the enforcement of any
assessment or penalty or otherwise, all such liability being, by the acceptance
hereof and as part of the consideration for the issuance hereof, expressly
waived and released.

         The Indenture imposes certain limitations on the ability of the Company
to, among other things, merge or consolidate with any other Person or sell,
assign, transfer, lease or convey all or substantially all of its properties and
assets. All such covenants and limitations are subject to a number of important
qualifications and exceptions. The Company must report periodically to the
Trustee on compliance with the covenants in the Indenture.

         The Debentures of this series are issuable only in registered form
without coupons, in denominations of $50 and any integral multiple thereof. As
provided in the Indenture and subject to certain limitations therein set forth,
Debentures of this series so issued are exchangeable for a like aggregate
principal amount of Debentures of this series of a different authorized
denomination, as requested by the Holder surrendering the same.

         [If Debenture is a Global Debenture, insert - This Debenture is a
Global Debenture and is subject to the provisions of the Indenture relating to
Global Debentures,

                                       10

<PAGE>

including the limitations in Section 2.11 of the Base Indenture on transfers and
exchanges of Global Debentures.]

         All terms used in this Debenture that are defined in the Indenture
shall have the meanings assigned to them in the Indenture.

         This Debenture shall be governed by and construed in accordance with
the laws of the State of New York.

                                       11

<PAGE>

                                   ASSIGNMENT

FOR VALUE RECEIVED, the undersigned assigns and transfers this Debenture to:


------------------------------------------------


------------------------------------------------


------------------------------------------------

        (Insert assignee's social security or tax identification number)


------------------------------------------------


------------------------------------------------


------------------------------------------------

                    (Insert address and zip code of assignee)

agent to transfer this Debenture on the Register. The agent may substitute
another to act for him or her.


Dated:


                                           Signed: _____________________________


                                           Signature Guarantee:

     (Sign exactly as your name appears on the other side of this Debenture)

     Signatures must be guaranteed by an "eligible guarantor institution"
meeting the requirements of the Registrar, which requirements include membership
or participation in the Security Transfer Agent Medallion Program ("STAMP") or
such other "signature guarantee program" as may be determined by the Registrar
in addition to, or in substitution for, STAMP, all in accordance with the
Securities Exchange Act of 1934, as amended.

                                       12

<PAGE>

                                   ARTICLE IV

                          ORIGINAL ISSUE OF DEBENTURES

SECTION 4.1. Original Issue of Debentures.

     Debentures in the aggregate principal amount of $230,000,000 may, upon
execution of this First Supplemental Indenture, be executed by the Company and
delivered to the Trustee for authentication, and the Trustee shall thereupon
authenticate and deliver said Debentures in accordance with a Company Order. The
Issue Date of the Debentures shall be November 2, 2001.

                                   ARTICLE V

                                  MISCELLANEOUS

SECTION 5.1. Ratification of Base Indenture.

     The Base Indenture, as supplemented by this First Supplemental Indenture,
is in all respects ratified and confirmed, and this First Supplemental Indenture
shall be deemed part of the Base Indenture in the manner and to the extent
herein and therein provided.

SECTION 5.2. Governing Law.

     THIS FIRST SUPPLEMENTAL INDENTURE AND EACH DEBENTURE SHALL BE GOVERNED BY
AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

SECTION 5.3. Not Responsible for Recitals.

     The recitals contained in this First Supplemental Indenture, except the
Trustee's certificate of authentication, shall be taken as the statements of the
Company, and the Trustee assumes no responsibility for their correctness and
makes no representation as to the validity or sufficiency of this First
Supplemental Indenture.

SECTION 5.4. Counterparts.

     This First Supplemental Indenture may be executed in any number of
counterparts each of which shall be an original; but such counterparts shall
together constitute but one and the same instrument.

                                       13

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this First Supplemental
Indenture to be duly executed by their respective officers thereunto duly
authorized, on the date or dates indicated in the acknowledgments and as of the
day and year first above written.

                                     ANTHEM, INC.,
                                       as Issuer

                                     By: /s/ Larry C. Glasscock
                                        -------------------------------
                                        Name:  Larry C. Glasscock
                                        Title: President and Chief Executive
                                               Officer


Attest:

 /s/ David R. Frick
---------------------------


                                     THE BANK OF NEW YORK,
                                       as Trustee

                                     By: /s/ Robert A. Massimillo
                                        -------------------------------
                                        Name:  Robert A. Massimillo
                                        Title: Vice President

Attest:

Terence T. Rawlins

 /s/ Terence T. Rawlins
-----------------------------
Vice President,
The Bank of New York



<PAGE>

State of Indiana   )
                   ) ss.:
County of Marion   )

           On the 2/nd/ day of November, 2001, before me personally came Larry
C. Glasscock, to me known, who, being by me duly sworn, did depose and say that
he is President and Chief Executive Officer of Anthem, Inc., one of the
corporations described in and which executed the foregoing instrument; that he
knows the seal of said corporation; that the seal affixed to said instrument is
such corporate seal; that it was so affixed by authority of the Board of
Directors of said corporation; and that he signed his name thereto by like
authority.

                                              /s/ Tracy L. Whitman
                                             -------------------------------
                                             Tracy L. Whitman, Notary Public
                                             My commission expires: May 13, 2008
                                             My county of residence: Marion

<PAGE>

State of New York     )
                      )  ss.
County of New York    )


           On the 2/nd/ day of November, 2001, before me personally came Robert
A. Massimillo to me known, who, being by me duly sworn, did depose and say that
he is Vice President of The Bank of New York, one of the corporations described
in and which executed the foregoing instrument; that he knows the seal of said
corporation; that the seal affixed to said instrument is such corporate seal;
that it was so affixed by authority of the Board of Directors of said
corporation; and that he signed his name thereto by like authority.

                                                         William J. Cassels

                                                         /s/  William J. Cassels
                                                         -----------------------
                                                         Notary Public,
                                                         State of New York