** **

**Exhibit 4.1**

 

**Osiris**

**THERAPEUTICS,INC.**

** **

INCORPORATED UNDER THELAWS OF THE STATE OF DELAWARE

 

 
| **CUSIP  68827R  10  8** |
|--------------------------------------------------------|
| See Reverse Side  For Certain Definitions              |

 

 

THIS IS TO CERTIFY that

 

 

 

is the owner of

 

 

 

**FULLY PAIDAND NON-ASSESSABLE SHARES OF THE COMMON STOCK, PAR VALUE $0.001 PER SHARE, OF**

**OSIRISTHERAPEUTICS, INC.**

transferable on the books of the Corporation in person or by dulyauthorized attorney upon surrender of this Certificate properly endorsed. ThisCertificate is not valid unless countersigned by the Transfer Agent andregistered by the Registrar.

IN WITNESS WHEREOF, the said Corporation has causedthis Certificate to be endorsed by the facsimile signatures of its dulyauthorized officers and to be sealed with the facsimile seal of theCorporation.

Dated

 
| /s/ illegible                          | /s/ illegible                          |
|----------------------------------------|----------------------------------------|
|                                   |                                   |
| CHIEF FINANCIAL  OFFICER AND SECRETARY | PRESIDENT AND  CHIEF EXECUTIVE OFFICER |

 

 

COUNTERSIGNED ANDREGISTERED:

 
| BY     |   | **STOCKTRANS,  INC.**   | ** **                    |
|--------|--------|-------------------------|-------------------------------|
|   |   | 44 West Lancaster  Ave. |                          |
|   |   | Ardmore, PA 19003       |                          |
|   |   |                    |                          |
|   |   |                    | TRANSFER AGENT AND REGISTRAR, |
|   |   |                    |                          |
|   |   |                    |                          |
|   |   |                    | AUTHORIZED SIGNATURE          |

 

 

 

 

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The following abbreviations, when used in theinscription on the face of this certificate, shall be construed as though theywere written out in full according to applicable laws or regulations:
|         |   |                                                                           |               |                          |      |         |
|---------|--------|--------------------------------------------------------------------------------|--------------------|-------------------------------|-----------|--------------|
| TEN COM | -      | as tenants in common                                                           | UNIF GIFT MIN ACT- | __________                    | Custodian | ____________ |
| TEN ENT | -      | as tenants by the entireties                                                   |               | (cust)                        |      | (Minor)      |
| JT TEN  | -      | as joint tenants with right of survivorship and not  as tenants in common |               | under Uniform Gifts to Minors |
|    |   |                                                                           |               |                          |      |         |
|    |   |                                                                           |               | Act                           |      |         |
|    |   |                                                                           |               |                          | (State)   |         |
|         |        |                                                                                |                    |                               |           |              |  |  |

 

Additional abbreviationsmay also be used though not in the above list.

 

For Value Received, ___________________ hereby sell, assign and or transferunto 

 
| PLEASE INSERT SOCIAL SECURITY OR OTHER |   |
|----------------------------------------|--------|
| IDENTIFYING  NUMBER OF ASSIGNEE        |   |
|                                   |   |
|                                   |   |

 

 
| (PLEASE PRINT OR TYPEWRITE NAME AND  ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)                                            |
|---------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                      |
|                                                                                                                      |
|                                                                                                                      |   |
|                                                                                                                      |   |
|                                                                                                                      |
|                                                                                                                      |   |
|                                                                                                                      |   |
|                                                                                                                      | Shares |
| of the capital stock represented by the within  Certificate, and do hereby irrevocably constitute and appoint             |   |
|                                                                                                                      |   |
|                                                                                                                      |   |
|                                                                                                                      | Attorney |
| to transfer the said stock on the books of the  within named Corporation with full power of substitution in the premises. |
|                                                                                                                      |
|                                                                                                                           |  |  |

 

 
| Dated                                                                                                                                                                                                                                                       |   |   |              |                                                                                                                                                                                        |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------|-------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                        |   |   |              |                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                        |   | **X**  |              |                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                        |   |   | (owner sign here) |
|                                                                                                                                                                                                                                                        |   |   |              |                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                        |   |   | **NOTICE:**       | THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND WITH  THE NAME AS WRITTEN UPON THE FACE OF THE CERTIFICATE IN EVERY PARTICULAR,  WITHOUT ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATEVER. |
|                                                                                                                                                                                                                                                        |   |   |              |                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                        |   |   |              |                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                        |   |   |              |                                                                                                                                                                                        |
| SIGNATURE(S) GUARANTEED:                                                                                                                                                                                                                                    |   |   |              |
|                                                                                                                                                                                                                                                        |   |   |              |                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                        |   |   |              |                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                        |   |
| THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE  GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND  CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION  PROGRAM), PURSUANT TO S.E.C. RULE 17Ad-15. |   |
|                                                                                                                                                                                                                                                             |        |        |                   |                                                                                                                                                                                             |  |

 

**KEEP THIS CERTIFICATE IN A SAFE PLACE. IF IT ISLOST, STOLEN, MUTILATED OR DESTROYED, THE CORPORATION WILL REQUIRE A BOND OFINDEMNITY AS A CONDITION TO THE ISSUANCE OF A REPLACEMENT CERTIFICATE.**

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