# Focus On Epilepsy Research

The epilepsies are a set of disorders characterized by recurring seizures, or disturbances in the electrical activity of the brain. Epilepsy affects people of all ages, from infants to the aged, and can result from many causes, including genetic variations, illness, head injury, or abnormal brain development. NIH/NINDS and its community-based research partners are dedicated to finding cures for the epilepsies and/or preventing epilepsy in individuals at risk for seizures.
> Featured NINDS Epilepsy Research Initiatives
The NINDS established the Centers Without Walls program in 2010 to rapidly advance epilepsy research through promoting interdisciplinary, collaborative research. Four centers have been funded:
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The Epilepsy 4000 (Epi4K) collaborative has examined genetic data from 4,000 individuals in order to understand the genes underlying epilepsy. See an NIH news release about the center.
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The Center for SUDEP Research (CSR) brings together extensive expertise to understand Sudden Unexplained Death in Epilepsy. See an NIH news release about the center.
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The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBiosS4Rx) will use studies of animals and patients with traumatic brain injury (TBI) leading to post-traumatic epilepsy (PTE) in order to develop future clinical trials of epilepsy prevention therapies.
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The Channelopathy-Associated Epilepsy Research Center (CAERC) will combine high-throughput technologies and high-content model systems to investigate the functional consequences of genetic variants in channelopathy-associated epilepsy.
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The Epilepsy Multiplatform Variant Prediction (EpiMVP) Center Without Walls will develop a modular, highly integrated platform approach to accelerate determination of the functional, pharmacological, neuronal network and whole animal consequences of genetic variants among a range of clinical epilepsy types.

> Estimates of Funding for Various Research, Condition, and Disease Categories

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Additional funding information on epilepsy research projects funded by the ICARE members, including federal and nonprofit organizations can be accessed at the Interagency Collaborative to Advance Research in Epilepsy Research Portfolio.

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*Dollars in millions and rounded
*To learn more about this NIH Investment, please visit the Categorical Spending webpage and enter "Epilepsy".*

## Related Federal Programs

Other federal partners with epilepsy research programs include:
                      - The Department of Defense's  Epilepsy Research Program .
                      - The CDC's  Epilepsy Program .

## Proceedings & Outcomes

**Status Epilepticus after Benzodiazepines: Seizures and Improving Long Term Outcomes**This virtual workshop convened preclinical and clinical researchers, as well as relevant stakeholders to discuss and define the indications of potential therapeutics needed to improve outcomes following SE. Topics of discussion will include refractory SE, post SE neuropathology, current clinical trials, gaps in the research for follow-on treatments and barriers to transitioning therapies to the clinic. Outcomes of the workshop will include a clearer understanding of the unmet therapeutic needs and identification of key gaps in the research, increasing the potential for new therapeutics development.
                      - Workshop Summary

**Post-Traumatic Epilepsy: Models, Common Data Elements and Optimization**The conference will set the stage to optimize preclinical and clinical research to prevent epileptogenesis following TBI. The results will help improve biomedical research in posttraumatic epilepsy.
                      - Workshop Summary

**ICARE: Interagency Collaborative to Advance Research in Epilepsy, 2021**Epilepsy research needs reach across the missions of multiple NIH Institutes and Centers and across many organizations outside the NIH.  As the primary NIH Institute for epilepsy research, NINDS leads this working group, with broad representation from the NIH, other Federal agencies, and the research and patient advocacy communities. Annual meetings provide a forum for sharing information about ongoing and planned epilepsy research activities, highlighting advances and discussing needs and opportunities, and promoting increased collaboration toward common research goals.
                      - Meeting Summary

**Curing the Epilepsies 2021**This conference, held January 4-6, 2021, was an opportunity for all epilepsy research stakeholders to provide input on the transformative research priorities for the field, and to come together to find ways to move forward "Curing the Epilepsies"
                      -  Conference Summary

**Accelerating the Development of Therapies for Anti-Epileptogenesis and Disease Modification**The “Accelerating the Development of Therapies for Anti-Epileptogenesis and Disease Modification” workshop, on August 6-7, 2018, brought together experts in the field of epilepsy to optimize and accelerate the development of therapies for anti-epileptogenesis and disease-modification in the epilepsies.
                      - Workshop Summary

## Benchmarks for Epilepsy Research

Benchmarks for Epilepsy Research
              - 2021 Benchmarks for Epilepsy Research
              - 2020 Benchmarks for Epilepsy Research                  - **2020 Editorial:**The Benchmarks: Progress and Emerging Priorities in Epilepsy Research
                - Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions
                - Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression
                - Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects
                - Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across the Life Span
              - 2014 Benchmarks for Epilepsy Research
              - Epilepsy Research Benchmarks Progress Update 2007-2009
              - 2007 Epilepsy Research Benchmarks

## Resources and Tools

#### Contacts

Adam Hartman, M.D. | Program Director, Office of Clinical Researchadam.hartman@nih.gov

George K. Essien Umanah, Ph.D. | Program Director, Channels, Synapses, and Circuitsumanahgk@ninds.nih.gov

Miriam Leenders, Ph.D. | Program Director, Channels Synapses & Circuitsmiriam.leenders@nih.gov

Vicky Whittemore, Ph.D. | Program Director, Channels Synapses & Circuitsvicky.whittemore@nih.gov

Ben Churn, Ph.D. | Program Director, Channels Synapses & Circuitssevern.churn@ninds.nih.gov

Brian Klein, Ph.D. | Program Director, Epilepsy Therapy Screening Programbrian.klein@nih.gov

#### Funding Opportunities 

Epilepsy Funding Opportunities

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Related Topics 
PANAChE Database
This resource contains public and non-confidential chemical structures and biological data for compounds which have been screened for efficacy and toxicity in animal models of epilepsy and related seizure disorders as part of the Epilepsy Therapy Screening Program (ETSP) at the National Institute of Neurological Disorders and Stroke.
Epilepsy Therapy Screening Program (ETSP)
This resource contains public and non-confidential chemical structures and biological data for compounds which have been screened for efficacy and toxicity in animal models of epilepsy and related seizure disorders as part of the Epilepsy Therapy Screening Program (ETSP) at the National Institute of Neurological Disorders and Stroke.
ICARE: Interagency Collaborative to Advance Research in Epilepsy
ICARE provides an interagency forum for sharing information about ongoing and planned epilepsy research activities.
Epilepsy Common Data Elements
The NINDS epilepsy common data elements provide data standards for clinical research in order to improve data quality and facilitate comparison and combination of data across studies.
The Epilepsy Research Connection (ERC)
The ERC provides information about grant and funding opportunities from non-profit and government organizations focused on epilepsy related research.