# Find Funding Opportunities

- Protective Strategies to Reduce Amyloid Related Imaging Abnormalities (ARIA) After Anti-Amyloid Beta Immunotherapy (R01 - Clinical Trial Not Allowed) Protective Strategies to Reduce Amyloid Related Imaging Abnormalities (ARIA) After Anti-Amyloid Beta Immunotherapy (R01 - Clinical Trial Not Allowed)ONCE Digital E...Fri, 04/12/2024 - 17:23            This initiative is designed to promote discovery of cellular and molecular mechanisms that underlie brain blood vessels responses to passive anti-beta-amyloid immunotherapy that result in amyloid-related imaging abnormalities (ARIA). The goal is to establish an understanding of molecular mechanisms that can be targeted to protect the blood brain barrier (BBB), and thus the brain blood vessels, during therapeutic interventions that target beta-amyloid.            Expiration Date              Wed, 11/06/2024 - 12:00                Funding Opportunity Number              PAR-24-198                Funding Opportunity Status              Open Opportunities                Link              http://grants.nih.gov/grants/guide/pa-files/PAR-24-198.html                Funding Opportunity Type              PAR                Funding Opportunity Activity Code                        R01                          Release Date              Wed, 04/10/2024 - 12:00
- Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Not Allowed) Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Not Allowed)ONCE Digital E...Fri, 04/12/2024 - 17:23            The purpose of the NIH Mentored Patient-Oriented Research Career Development Award (K23) is to support the career development of individuals with a clinical doctoral degree who have made a commitment to focus their research endeavors on patient-oriented research.            Expiration Date              Fri, 05/07/2027 - 12:00                Funding Opportunity Number              PA-24-185                Funding Opportunity Status              Open Opportunities                Link              http://grants.nih.gov/grants/guide/pa-files/PA-24-185.html                Funding Opportunity Type              PA                Funding Opportunity Activity Code                        K23                          Release Date              Tue, 04/09/2024 - 12:00
- Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Basic Experimental Studies with Humans Required) Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Basic Experimental Studies with Humans Required)ONCE Digital E...Fri, 04/12/2024 - 17:23            The purpose of the NIH Mentored Patient-Oriented Research Career Development Award (K23) is to support the career development of individuals with a clinical doctoral degree who have made a commitment to focus their research endeavors on patient-oriented research.            Expiration Date              Fri, 05/07/2027 - 12:00                Funding Opportunity Number              PA-24-186                Funding Opportunity Status              Open Opportunities                Link              http://grants.nih.gov/grants/guide/pa-files/PA-24-186.html                Funding Opportunity Type              PA                Funding Opportunity Activity Code                        K23                          Release Date              Tue, 04/09/2024 - 12:00
- Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Required) Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Required)ONCE Digital E...Fri, 04/12/2024 - 17:23            The purpose of the NIH Mentored Patient-Oriented Research Career Development Award (K23) is to support the career development of individuals with a clinical doctoral degree who have made a commitment to focus their research endeavors on patient-oriented research.            Expiration Date              Fri, 05/07/2027 - 12:00                Funding Opportunity Number              PA-24-184                Funding Opportunity Status              Open Opportunities                Link              http://grants.nih.gov/grants/guide/pa-files/PA-24-184.html                Funding Opportunity Type              PA                Funding Opportunity Activity Code                        K23                          Release Date              Tue, 04/09/2024 - 12:00
- Mechanistic and Hemodynamic Basis of Diffuse White Matter Disease in Vascular Contributions to Cognitive Impairment and Dementia (VCID)(R01 - Clinical Trial Not Allowed) Mechanistic and Hemodynamic Basis of Diffuse White Matter Disease in Vascular Contributions to Cognitive Impairment and Dementia (VCID)(R01 - Clinical Trial Not Allowed)ONCE Digital E...Fri, 04/12/2024 - 17:23            (Reissue of RFA-NS-16-021, PAR-18-413, RFA-NS-19-039) Diffuse brain white matter disease is highly prevalent in the elderly, and has been clinically associated with vascular contributions to cognitive impairment and dementia (VCID) in both men and women. Diffuse white matter disease is thought to include a variety of pathologies including demyelination and/or fiber loss due to multifocal infarction and local ischemia. It is often accompanied by arteriosclerosis in deep penetrating arteries, multiple infarcts in the basal ganglia, brainstem or cerebellum. Though most commonly extending out from the periventricular surfaces, it may also occur in subcortical white matter. Diffuse white matter disease is typically detected in clinical settings as hyperintensity on magnetic resonance imaging (MRI) or signal loss on computed tomography x-ray (CT) scan; diffuse white matter disease can be detected histologically as well, for example in human pathology and in studies using animal models. Despite the prevalence and potential significance of white matter disease for cerebrovascular disease etiology and cognitive outcomes, much remains to be learned about the cellular and molecular causes, regional vulnerability, and progression over time.  The physiological consequences of diffuse white matter disease on local axon and neural circuit function are almost completely unknown. The purpose of this FOA is to address some of the many gaps in knowledge of the biologic mechanisms of the commonly occurring, cerebrovascular disease and age-related diffuse white matter disease at the molecular, cellular, tissue and brain circuit level. The ultimate goal of this fundamental research is to inform future efforts to reduce the burden of illness due to age-related vascular contributions to cognitive impairment and dementia.            Expiration Date              Sat, 10/05/2024 - 12:00                Funding Opportunity Number              PAR-24-196                Funding Opportunity Status              Open Opportunities                Link              http://grants.nih.gov/grants/guide/pa-files/PAR-24-196.html                Funding Opportunity Type              PAR                Funding Opportunity Activity Code                        R01                          Release Date              Fri, 04/05/2024 - 12:00
- Single Source for the Continuation of the Data Management and Coordinating Center (DMCC) for Rare Diseases Clinical Research Network (RDCRN) (U2C Clinical Trial Not Allowed) Single Source for the Continuation of the Data Management and Coordinating Center (DMCC) for Rare Diseases Clinical Research Network (RDCRN) (U2C Clinical Trial Not Allowed)ONCE Digital E...Fri, 04/12/2024 - 17:23            This is a non-competitive funding opportunity intended to fund a single award. NCATS is announcing its intent to issue a single source cooperative agreement to Cincinnati Childrens Hospital Medical Center (CCHMC) to support the Data Management and Coordinating Center. The Rare Diseases Clinical Research Network (RDCRN) is intended to advance and improve diagnosis, management, and treatment of numerous, diverse rare diseases through highly collaborative, multi-site, patient-centric, translational, and clinical research with an emphasis on early and timely identification of individuals with rare diseases and clinical trial readiness. The DMCC facilitates and supports the activities of each individual Rare Diseases Clinical Research Consortium (RDCRC) along with trans-network activities that broadly facilitate the advancement of rare disease research via four avenues: administrative support, data management support, clinical research support and patient engagement, and broad dissemination of information. The RDCRCs will continue conducting research conducted under a separate NOFO.            Expiration Date              Tue, 07/23/2024 - 12:00                Funding Opportunity Number              RFA-TR-24-021                Funding Opportunity Status              Open Opportunities                Link              http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-24-021.html                Funding Opportunity Type              RFA                Funding Opportunity Activity Code                        U2C                          Release Date              Fri, 04/05/2024 - 12:00
- Medical Rehabilitation Research Resource (P50 Clinical Trial Optional) Medical Rehabilitation Research Resource (P50 Clinical Trial Optional)ONCE Digital E...Fri, 04/05/2024 - 17:23            This Notice of Funding Opportunity (NOFO) invites grant applications from institutions/organizations that propose to build a Medical Rehabilitation Research Center. The centers will have a specific rehabilitation research theme and be comprised of a research project supported by 3 cores. The 3 cores will have functions within the center as well as functions nationwide. Together, the cores will support: administrative functions (including an optional pilot program), resource sharing, and community engagement and outreach. The Medical Rehabilitation Research Centers will contribute tomedical rehabilitation research infrastructure by developing and disseminating techniques, data, theories, research programs, and expertise with the goal of enhancing the capability of medical rehabilitation investigators to understand mechanisms of functional recovery, develop therapeutic strategies, identify clinical care gaps, and improve the lives of people with disabilities. Applications must include a plan for inclusion of People with Lived Experience (as a required other attachment) that is relevant to the research theme of the center and increases the potential impact of the center.            Expiration Date              Wed, 07/31/2024 - 12:00                Funding Opportunity Number              RFA-HD-25-001                Funding Opportunity Status              Open Opportunities                Link              http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-25-001.html                Funding Opportunity Type              RFA                Funding Opportunity Activity Code                        P50                          Release Date              Wed, 04/03/2024 - 12:00
- Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional) Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)ONCE Digital E...Fri, 04/05/2024 - 17:23            The objective of this Notice of Funding Opportunity (NOFO) is to invite new and renewal applications for the Rare Diseases Clinical Research Consortia (RDCRC) that comprise the Rare Diseases Clinical Research Network (RDCRN). The RDCRCs are intended to advance and improve diagnosis, management, and treatment of numerous, diverse rare diseases through highly collaborative, multi-site, patient-centric, translational and clinical research. Special emphasis will be placed on the early and timely identification of individuals with rare diseases and clinical trial readiness.            Expiration Date              Wed, 08/14/2024 - 12:00                Funding Opportunity Number              PAR-24-206                Funding Opportunity Status              Open Opportunities                Link              http://grants.nih.gov/grants/guide/pa-files/PAR-24-206.html                Funding Opportunity Type              PAR                Funding Opportunity Activity Code                        U54                          Release Date              Tue, 04/02/2024 - 12:00
- Tools and resources to understand the vascular pathophysiology of in vivo neuroimaging findings in ARIA (U24 - Clinical Trials Not Allowed) Tools and resources to understand the vascular pathophysiology of in vivo neuroimaging findings in ARIA (U24 - Clinical Trials Not Allowed)ONCE Digital E...Fri, 04/05/2024 - 17:23            The purpose of this Alzheimers Disease-Related Dementia (ADRD) initiative is to promote the development and distribution of innovative technologies, methods, protocols, and biomedical materials that enhance combined human neuropathology and neuroimaging research with data aimed at understanding the underlying pathophysiology of in vivo imaging results typically associated with vascular contributions to cognitive impairment and dementia (VCID) in TBI-related dementia and other ADRD diagnoses.Resources developed under this FOA must follow open data sharing practices and are intended to expand the broader research communitys capacity to perform research aimed at neuropathologically-informed understanding of the vascular pathophysiology of clinically-relevant, in vivo neuroimaging findings.            Expiration Date              Mon, 06/03/2024 - 12:00                Funding Opportunity Number              RFA-NS-24-034                Funding Opportunity Status              Open Opportunities                Link              http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-034.html                Funding Opportunity Type              RFA                Funding Opportunity Activity Code                        U24                          Release Date              Thu, 03/28/2024 - 12:00
- NINDS Program Project Grant (P01 Clinical Trial Optional) NINDS Program Project Grant (P01 Clinical Trial Optional)ONCE Digital E...Fri, 04/05/2024 - 17:23            This notice of opportunity announcement (NOFO) is issued by the National Institute of Neurological Disorders and Stroke to enable submission of program project grant applications that propose to conduct innovative, interactive research to answer significant scientific questions that are important for the mission of NINDS, via a synergistic collaboration between outstanding scientists who might not otherwise collaborate. The program project grant is designed to support research in which the funding of several interdependent highly meritorious projects as a group offers significant scientific advantages over support of these same projects as individual research grants.            Expiration Date              Wed, 01/08/2025 - 12:00                Funding Opportunity Number              PAR-24-169                Funding Opportunity Status              Open Opportunities                Link              http://grants.nih.gov/grants/guide/pa-files/PAR-24-169.html                Funding Opportunity Type              PAR                Funding Opportunity Activity Code                        P01                          Release Date              Wed, 03/27/2024 - 12:00