Exhibit 24.1



POWER OF ATTORNEY



Each of the undersigned officers and directors of Navidea Biopharmaceuticals,
Inc., a Delaware corporation (the “Company”), does hereby constitute and appoint Mark J. Pykett and Brent L. Larson
as his agents and lawful attorneys-in-fact, or either one of them individually with power to act without the other, as his agent
and lawful attorney-in-fact, in his name and on his behalf, and in any and all capacities stated below:



| | · | To sign and file
                                                                                                          with the United States
                                                                                                          Securities and Exchange
                                                                                                          Commission the Annual
                                                                                                          Report of the Company
                                                                                                          on Form 10-K (the “Annual
                                                                                                          Report”) for the
                                                                                                          fiscal year ended December
                                                                                                          31, 2012, and any amendments
                                                                                                          or supplements to such
                                                                                                          Annual Report; and
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | To execute and deliver
                                                                                                          any instruments, certificates
                                                                                                          or other documents which
                                                                                                          they shall deem necessary
                                                                                                          or proper in connection
                                                                                                          with the filing of such
                                                                                                          Annual Report, and generally
                                                                                                          to act for and in the
                                                                                                          name of the undersigned
                                                                                                          with respect to such
                                                                                                          filing as fully as could
                                                                                                          the undersigned if then
                                                                                                          personally present and
                                                                                                          acting.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Each agent named above is hereby empowered to determine in
his discretion the times when, the purposes for, and the names in which, any power conferred upon him herein shall be exercised
and the terms and conditions of any instrument, certificate or document which may be executed by him pursuant to this instrument.



This Power of Attorney shall not be affected by the disability
of any of the undersigned or the lapse of time.



The validity, terms and enforcement of this Power of Attorney
shall be governed by those laws of the State of Ohio that apply to instruments negotiated, executed, delivered and performed solely
within the State of Ohio.



This Power of Attorney may be executed in any number of counterparts,
each of which shall have the same effect as if it were the original instrument and all of which shall constitute one and the same
instrument.



IN WITNESS WHEREOF, the undersigned have
executed this Power of Attorney effective as of March 8, 2013.



|Signature                     |  | Title                                                         
|----------------------------- |  | --------------------------------------------------------------
|                              |  |                                                               
|/s/ Mark J. Pykett            |  | President, Chief Executive Officer and Director               
|Mark J. Pykett, V.M.D., Ph.D. |  | (principal executive officer)                                 
|                              |  |                                                               
|/s/ Brent L. Larson           |  | Senior Vice President and Chief Financial Officer             
|Brent L. Larson               |  | (principal financial officer and principal accounting officer)
|                              |  |                                                               
|/s/ Gordon A. Troup           |  | Chairman of the Board of Directors                            
|Gordon A. Troup               |  |                                                               
|                              |  |                                                               
|/s/ Peter F. Drake            |  | Director                                                      
|Peter F. Drake, Ph.D.         |  |                                                               
|                              |  |                                                               
|/s/ Brendan A. Ford           |  | Director                                                      
|Brendan A. Ford               |  |                                                               
|                              |  |                                                               
|/s/ Jess Emery Jones          |  | Director                                                      
|Jess Emery Jones, M.D.        |  |                                                               
|                              |  |                                                               
|/s/ Eric K. Rowinsky          |  | Director                                                      
|Eric K. Rowinsky, M.D.        |  |