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Select project titles to get information on the abstracts, budgets, publications, patents, and contact information associated with each CounterACT-supported  grant from the NIH RePORTER database.

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              This is a preview of the Data Table. Only the first three rows are displayed.
    
    
          Grant Type
                                                                              Toxidrome (category)
                                                                              Title
                                                                              PI / Project Lead
                                                                              InstitutionUG3
                                                              Nerve Agent
                                                              Identification and optimization of verapamil as a novel neuroprotective and anti-inflammatory agent for reducing long-term neurological morbidities following organophosphate-induced status epilepticus
                                                              DESHPANDE, LAXMIKANT S
                                                              VIRGINIA COMMONWEALTH UNIVERSITYUG3
                                                              Nerve Agent
                                                              Long-acting aldicarb hydrolase as a medical countermeasure for aldicarb poisoning
                                                              ZHENG, FANG
                                                              UNIVERSITY OF KENTUCKYUG3
                                                              Vesicating Agent
                                                              Development of small molecule inhibitors as anti-inflammatory agents and antidotes for arsenicals
                                                              AUGELLI-SZAFRAN, CORINNE ELIZABETH
                                                              SOUTHERN RESEARCH INSTITUTEU54
                                                              Metabolic/Cellular Poison
                                                              Advancing Novel Cyanide Countermeasures
                                                              MACRAE, CALUM A
                                                              BRIGHAM AND WOMEN'S HOSPITALU54
                                                              Nerve Agent
                                                              UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate Intoxication
                                                              LEIN, PAMELA J
                                                              UNIVERSITY OF CALIFORNIA AT DAVISU54
                                                              Vesicating Agent
                                                              Rutgers University CounterACT Center of Excellence
                                                              LASKIN, JEFFREY D
                                                              RUTGERS BIOMEDICAL AND HEALTH SCIENCESU54
                                                              Vesicating Agent
                                                              Barrier Damage and The Immune CascadeNorthwestern University CounterACT Center of Excellence  (NUCCX)
                                                              LU, KURT
                                                              NORTHWESTERN UNIVERSITY AT CHICAGOU54
                                                              Vesicating Agent
                                                              UAB Research Center of Excellence in Arsenicals
                                                              ATHAR, MOHAMMAD
                                                              UNIVERSITY OF ALABAMA AT BIRMINGHAMU01
                                                              Anticoagulant
                                                              Optimization of Bile Sequestrants to Treat Superwarfarin Poisoning
                                                              FEINSTEIN, DOUGLAS L
                                                              UNIVERSITY OF ILLINOIS AT CHICAGOU01
                                                              Metabolic/Cellular Poison
                                                              Optimization of a Combined Drug and Delivery Device for Treatment of Cyanide Poisoning
                                                              PATTERSON, STEVEN E
                                                              UNIVERSITY OF MINNESOTAU01
                                                              Nerve Agent
                                                              Novel Counteract Agents To Reduce Mortality And Morbidity Following Organophosphate Status Epilepticus
                                                              DESHPANDE, LAXMIKANT S
                                                              VIRGINIA COMMONWEALTH UNIVERSITYU01
                                                              Nerve Agent
                                                              Advanced Development of Drugs to Mitigate Parathion Intoxication
                                                              LASKIN, JEFFREY D
                                                              RUTGERS BIOMEDICAL AND HEALTH SCIENCESU01
                                                              Nerve Agent
                                                              Novel Antibody-Oxime Pairing to Reduce Circulating Organophosphate Levels.
                                                              THOMPSON, CHARLES MARK
                                                              HUMAN BIOMOLECULAR RESEARCH INSTITUTEU01
                                                              Nerve Agent
                                                              Novel pediatric anticonvulsants for nerve agents
                                                              REDDY, DOODIPALA SAMBA
                                                              TEXAS A&M UNIVERSITY HEALTH SCIENCE CTRU01
                                                              Nerve Agent
                                                              Novel Water-Soluble Adjunct Anticonvulsants for Nerve Agents
                                                              REDDY, DOODIPALA SAMBA
                                                              TEXAS A&M UNIVERSITY HEALTH SCIENCE CTRU01
                                                              Nerve Agent
                                                              Saracatinib and 1400W Counteract Nerve Agents-Induced Long-Term Neurotoxicity
                                                              THIPPESWAMY, THIMMASETTAPPA
                                                              IOWA STATE UNIVERSITYU01
                                                              Nerve Agent
                                                              Antiglutamatergic Therapy to Protect the Brain Against Nerve Agents
                                                              BRAGA, MARIA F
                                                              HENRY M. JACKSON FDN FOR THE ADV MIL/MEDU01
                                                              Nerve Agent
                                                              Optimization of Substituted Phenoxyalkyl Pyridinium Oximes as Therapies for Organophosphate Poisoning
                                                              CHAMBERS, JANICE ELAINE
                                                              MISSISSIPPI STATE UNIVERSITYU01
                                                              Pulmonary Agent
                                                              Optimization of AEOL10150 treatment of sulfur mustard-induced lung toxidrome in a pig model
                                                              DAY, BRIAN J
                                                              NATIONAL JEWISH HEALTHU01
                                                              Pulmonary Agent
                                                              Advanced TRPA1 Inhibitor for the Treatment of Chlorine Inhalation Injury
                                                              JORDT, SVEN-ERIC
                                                              DUKE UNIVERSITYU01
                                                              Pulmonary Agent
                                                              Antidotes against HCI-induced chronic lung injury
                                                              CATRAVAS, JOHN D
                                                              OLD DOMINION UNIVERSITYU01
                                                              Pulmonary Agent
                                                              Novel lead compound advancement for mitigating halogen-induced mortality and morbidity.
                                                              AHMAD, SHAMA
                                                              UNIVERSITY OF ALABAMA AT BIRMINGHAMU01
                                                              Pulmonary Agent
                                                              Identification of AMD3100 (Plerixafor) as a potential lead compound for chlorine toxicity
                                                              AGGARWAL, SAURABH
                                                              UNIVERSITY OF ALABAMA AT BIRMINGHAMU01
                                                              Ultra-potent synthetic opioid
                                                              Development of Agents for Synthetic Opioid Overdose
                                                              PRISINZANO, THOMAS EDWARD
                                                              UNIVERSITY OF KENTUCKYU01
                                                              Ultra-potent synthetic opioid
                                                              Antibody-based countermeasures against fentanyl and its analogues
                                                              PRAVETONI, MARCO
                                                              UNIVERSITY OF WASHINGTONU01
                                                              Vesicating Agent
                                                              Translation of novel and repurposed drugs to address the acute and late effects of mustard exposure
                                                              LU, KURT
                                                              NORTHWESTERN UNIVERSITY AT CHICAGOU01
                                                              Vesicating Agent
                                                              Targeted Therapeutic Approaches to Counteract Toxicity from Phosgene Oxime Skin Exposure
                                                              TEWARI-SINGH, NEERA
                                                              MICHIGAN STATE UNIVERSITYU01
                                                              Vesicating Agent
                                                              Optimization of Novel Molecular Target-based Drugs for Arsenical Skin Injury
                                                              ATHAR, MOHAMMAD
                                                              UNIVERSITY OF ALABAMA AT BIRMINGHAMU01
                                                              Vesicating Agent
                                                              Dexamethasone as an Effective Therapy for Ocular Injuries by Vesicating Agents.
                                                              AGARWAL, RAJESH
                                                              UNIVERSITY OF COLORADO DENVERU01
                                                              Vesicating Agent
                                                              Turbo Eye Drops to Treat Ocular Toxicity and Blindness from Sulfur Mustard
                                                              MOHAN, RAJIV RAVINDRA
                                                              UNIVERSITY OF MISSOURI-COLUMBIAU01
                                                              Vesicating Agent
                                                              First Aid Medicine to Treat Vesicant Induced Corneal Injury
                                                              CHANDLER, HEATHER
                                                              OHIO STATE UNIVERSITYR56
                                                              Pulmonary Agent
                                                              Mast Cell Activation as a Common Mechanism of Pulmonary Toxicity by Chemical Threat Agents
                                                              BROWN, JARED MICHAEL
                                                              UNIVERSITY OF COLORADO DENVERR56
                                                              Pulmonary Agent
                                                              Discovery of phosgene and chlorine gas modes of action and therapeutic targets using chemoproteomic profiling strategies
                                                              LIN, VIVIAN S
                                                              BATTELLE PACIFIC NORTHWEST LABORATORIESR56
                                                              Pulmonary Agent
                                                              Mechanisms underlying mustard gas-induced conjunctival injury and use of lipid mediators as medical countermeasures
                                                              DARTT, DARLENE A
                                                              SCHEPENS EYE RESEARCH INSTITUTER56
                                                              Pulmonary Agent
                                                              Unraveling the corneal and retinal mechanisms of chemical injury
                                                              MOHAN, ROYCE
                                                              UNIVERSITY OF CONNECTICUT SCH OF MED/DNTR56
                                                              Pulmonary Agent
                                                              Mechanistic Understanding of Mustard Gas Toxicity in the Retina using a Minipig Model
                                                              CHAURASIA, SHYAM SUNDER
                                                              MEDICAL COLLEGE OF WISCONSINR56
                                                              Ultra-potent synthetic opioid
                                                              Identifying novel molecular targets, signaling pathways and mechanisms underlying fentanyl overdose-induced severe respiratory depression and lethality in rats using TMT phosphoproteomics/proteomics
                                                              PAN, YING-XIAN
                                                              RUTGERS BIOMEDICAL AND HEALTH SCIENCESR56
                                                              Ultra-potent synthetic opioid
                                                              Dissecting the central and peripheral mechanisms to fentanyl induced respiratory depression
                                                              MORON-CONCEPCION, JOSE A
                                                              WASHINGTON UNIVERSITYR56
                                                              Vesicating Agent
                                                              Extracellular vesicles as mediators of injury in inhaled exposures to toxic chemicals.
                                                              AHMAD, AFTAB
                                                              UNIVERSITY OF ALABAMA AT BIRMINGHAMR34
                                                              Vesicating Agent
                                                              The Role of Macrophages in Vesicant Skin Injury and Repair
                                                              KOH, TIMOTHY J
                                                              UNIVERSITY OF ILLINOIS AT CHICAGOR34
                                                              Vesicating Agent
                                                              The Initiation of Vesicant Skin Injury at a Single Cell Level
                                                              ANDERSEN, BOGI
                                                              UNIVERSITY OF CALIFORNIA-IRVINER34
                                                              Vesicating Agent
                                                              Oxidized lipids and microvesicle particles as effectors for chemical threats to skin
                                                              TRAVERS, JEFFREY B
                                                              WRIGHT STATE UNIVERSITYR34
                                                              Vesicating Agent
                                                              Explant human skin perfusion model to study mechanisms of chemical injury and mitigation
                                                              EJAZ, ASIM
                                                              UNIVERSITY OF PITTSBURGH AT PITTSBURGHR21
                                                              Metabolic/Cellular Poison
                                                              Treatment strategies for ocular toxicity from chloropicrin
                                                              TEWARI-SINGH, NEERA
                                                              MICHIGAN STATE UNIVERSITYR21
                                                              Metabolic/Cellular Poison
                                                              Hydrogen sulfide toxicity to the cornea
                                                              MOHAN, RAJIV RAVINDRA
                                                              UNIVERSITY OF MISSOURI-COLUMBIAR21
                                                              Nerve Agent
                                                              Refined uncharged Bis-Oximes for Rapid CNS Reactivation of OP-Inhibited hAChE.
                                                              RADIC, ZORAN
                                                              UNIVERSITY OF CALIFORNIA, SAN DIEGOR21
                                                              Nerve Agent
                                                              In Vivo Efficacy of Novel Uncharged Bis-Oximes in OP Poisoning Treatment
                                                              RADIC, ZORAN
                                                              UNIVERSITY OF CALIFORNIA, SAN DIEGOR21
                                                              Nerve Agent
                                                              Mitoapocynin, a novel NOX2 inhibitor, mitigates nerve agents induced longterm neurotoxicity
                                                              THIPPESWAMY, THIMMASETTAPPA
                                                              IOWA STATE UNIVERSITYR21
                                                              Nerve Agent
                                                              Converting human butyrylcholinesterase into a metalloenzyme for catalytic hydrolysis of organophosphates
                                                              SHAFAAT, HANNAH S
                                                              UNIVERSITY OF CALIFORNIA LOS ANGELESR21
                                                              Nerve Agent
                                                              High-throughput in vivo discovery of novel countermeasures against organophosphate-induced seizure and status epilepticus using zebrafish
                                                              MCGRAW, CHRISTOPHER
                                                              MASSACHUSETTS GENERAL HOSPITALR21
                                                              Nerve Agent
                                                              Novel oxime antidotes for an organophosphate insecticide requiring bioactivation
                                                              MEEK, EDWARD C
                                                              MISSISSIPPI STATE UNIVERSITYR21
                                                              Nerve Agent
                                                              The role of adaptive immunity in organophosphate induced CNS injury
                                                              ABDULLAH, LAILA
                                                              ROSKAMP INSTITUTE, INC.R21
                                                              Nerve Agent
                                                              Novel behavioral screening tool for therapeutics against organophosphorus agents
                                                              COLLINS, EVA-MARIA SCHOETZ
                                                              SWARTHMORE COLLEGER21
                                                              Nicotine
                                                              An Enzyme-Based Antidote for Acute Nicotine Toxicity
                                                              JANDA, KIM
                                                              SCRIPPS RESEARCH INSTITUTE, THER21
                                                              Pulmonary Agent
                                                              Cationic CAMKIIN nanoparticles that reduce chlorine-induced airway oxidative stress
                                                              SALEM, ALIASGER K
                                                              UNIVERSITY OF IOWAR21
                                                              Pulmonary Agent
                                                              Repurposing thiosulfate for chlorine gas exposure
                                                              DAY, BRIAN J
                                                              NATIONAL JEWISH HEALTHR21
                                                              Pulmonary Agent
                                                              Cannabinoid-2 receptor signaling in vesicant induced lung injury
                                                              NAGRE, NAGARAJA
                                                              EASTERN VIRGINIA MEDICAL SCHOOLR21
                                                              Pulmonary Agent
                                                              Inhibition of soluble epoxide hydrolase protects against phosgene-induced lung injuries
                                                              ACHANTA, SATYANARAYANA
                                                              DUKE UNIVERSITYR21
                                                              Pulmonary Agent
                                                              Sickle Cell Trait Mice are More Susceptible to Chlorine Exposure and Haptoglobin Improves the Outcomes
                                                              ALISHLASH, AMMAR
                                                              UNIVERSITY OF ALABAMA AT BIRMINGHAMR21
                                                              Ultra-potent synthetic opioid
                                                              Restoring The Mechanical Properties of the Respiratory System as a Treatment of Fentanyl Overdose-Induced Hypoventilation using Kappa Agonists
                                                              HAOUZI, PHILIPPE A
                                                              CLEVELAND CLINIC LERNER COM-CWRUR21
                                                              Ultra-potent synthetic opioid
                                                              New brainstem targets for counteracting opioid induced apnea
                                                              FELDMAN, JACK L
                                                              UNIVERSITY OF CALIFORNIA LOS ANGELESR21
                                                              Ultra-potent synthetic opioid
                                                              Zebrafish Screens to Identify Agents which Reverse the Effects of Synthetic Opioids
                                                              SCHIEFER, ISAAC T
                                                              UNIVERSITY OF TOLEDO HEALTH SCI CAMPUSR21
                                                              Ultra-potent synthetic opioid
                                                              Recruiting active expiration to overcome opioid-induced persistent apnea
                                                              FELDMAN, JACK L
                                                              UNIVERSITY OF CALIFORNIA LOS ANGELESR21
                                                              Ultra-potent synthetic opioid
                                                              Repurposing L-NAC to prevent fentanyl-induced respiratory depression
                                                              LEWIS, STEPHEN JOHN
                                                              CASE WESTERN RESERVE UNIVERSITYR21
                                                              Ultra-potent synthetic opioid
                                                              Synthetic Scavenger Medical Countermeasures for Fentanyl
                                                              AVITAL-SHMILOVICI, MICHAL
                                                              SRI INTERNATIONALR21
                                                              Vesicating Agent
                                                              Development of a protein therapeutics to counteract mustard-induced skin injury
                                                              LI, HAICHANG
                                                              OHIO STATE UNIVERSITYR21
                                                              Vesicating Agent
                                                              Targeting Citrullination in Ocular Chemical Injury
                                                              MOHAN, ROYCE
                                                              UNIVERSITY OF CONNECTICUT SCH OF MED/DNTR21
                                                              Vesicating Agent
                                                              Extracellular Vesicles derived from Mesenchymal Stem Cells as an Effective Medical Countermeasure against Mustard Induced Ocular Injury
                                                              LEE, RYANG HWA
                                                              TEXAS A&M UNIVERSITY HEALTH SCIENCE CTRR21
                                                              Vesicating Agent
                                                              Antioxidant Eye Wash Formulations to Counter Ocular Chemical Threats
                                                              LEBRUN, STEWART
                                                              LEBRUN LABS, LLCR21
                                                              Vesicating Agent
                                                              Tissue Hypoxia and Topical Oxygen Therapy in Ocular Mustard Gas Injury
                                                              YIN, JIA
                                                              SCHEPENS EYE RESEARCH INSTITUTER01
                                                              Pulmonary Agent
                                                              Halolipid-Neutrophil Extracellular Trap Axis in Halogen Lung Injury
                                                              FORD, DAVID A
                                                              SAINT LOUIS UNIVERSITYR01
                                                              Pulmonary Agent
                                                              Pulmonary cell fate and lung repair in rodent and porcine models of chlorine and phosgene inhalation injuries
                                                              JORDT, SVEN-ERIC
                                                              DUKE UNIVERSITYR01
                                                              Pulmonary Agent
                                                              Characterizing chemical threat agent exposures using a lung-on-a-chip platform and multi-omic analysis of common pathophysiological mechanisms
                                                              MURPHY, SEAN VINCENT
                                                              WAKE FOREST UNIVERSITY HEALTH SCIENCESR01
                                                              Pulmonary Agent
                                                              Pulmonary Pathophysiologic Mechanisms of Chloropicrin and Phosgene
                                                              VAN WINKLE, LAURA S
                                                              UNIVERSITY OF CALIFORNIA AT DAVISR01
                                                              Pulmonary Agent
                                                              Pathophysiological Mechanisms of Chemical-Induced Acute Lung Injury
                                                              LEIKAUF, GEORGE DOUGLAS
                                                              UNIVERSITY OF CINCINNATIR01
                                                              Pulmonary Agent
                                                              Lipid and metabolic mechanisms responsible for phosgene and phosphorus trichloride exposure toxicity
                                                              FORD, DAVID A
                                                              SAINT LOUIS UNIVERSITYR01
                                                              Pulmonary Agent
                                                              Vascular injury and repair predict divergent late onset cardiovascular morbidities after chlorine and sulfur mustard exposure
                                                              VERESS, LIVIA AGNES
                                                              UNIVERSITY OF COLORADO DENVERR01
                                                              Pulmonary Agent
                                                              Mitochondrial DNA Injury is a Key Contributor to the Development of Chemical Lung Injury
                                                              MATALON, SADIS
                                                              UNIVERSITY OF ALABAMA AT BIRMINGHAMR01
                                                              Ultra-potent synthetic opioid
                                                              Transcriptomic single-cell profiling in breathing-specific parabrachial mu-opioid receptor neurons
                                                              HAN, SUNG
                                                              SALK INSTITUTE FOR BIOLOGICAL STUDIESR01
                                                              Ultra-potent synthetic opioid
                                                              Genetic Variation of Ultra-Potent Synthetic Opioid Sensitivity in Mice
                                                              BUBIER, JASON A
                                                              JACKSON LABORATORYR01
                                                              Ultra-potent synthetic opioid
                                                              Mechanism and Countermeasure of Carfentanil-induced Respiratory Disorder and Death
                                                              XU, FADI
                                                              LOVELACE BIOMEDICAL RESEARCH INSTITUTER01
                                                              Vesicating Agent
                                                              The mechanism of vesicant-induced ocular injury
                                                              GORBATYUK, MARINA
                                                              UNIVERSITY OF ALABAMA AT BIRMINGHAMR01
                                                              Vesicating Agent
                                                              Toxic Mechanisms of Vesicating Chemicals in the Eye
                                                              MCNUTT, PATRICK MICHAEL
                                                              WAKE FOREST UNIVERSITY HEALTH SCIENCESR01
                                                              Vesicating Agent
                                                              Understanding Mustard Vesicants Distribution and Toxicity in the Eye Using In Vivo and In Silico Models
                                                              TEWARI-SINGH, NEERA
                                                              MICHIGAN STATE UNIVERSITYR01
                                                              Vesicating Agent
                                                              The Role of Master Epigenetic Regulators in Ocular Chemical Injury
                                                              ZHANG, WENBO
                                                              UNIVERSITY OF TEXAS MED BR GALVESTONR01
                                                              Vesicating Agent
                                                              Late/chronic corneal injury following threat chemical exposure
                                                              MOHAN, RAJIV RAVINDRA
                                                              UNIVERSITY OF MISSOURI-COLUMBIAR01
                                                              Vesicating Agent
                                                              Mitochondria and Mustard Damage at the Ocular Surface
                                                              FINI, M ELIZABETH
                                                              TUFTS MEDICAL CENTERR01
                                                              Vesicating Agent
                                                              Soluble epoxide hydrolase and epoxide fatty acid involvement in corneal injury after ammonia exposure: Mechanisms of injury and potential therapeutics using sEH inhibitors and biostable EpFA mimics.
                                                              WATSKY, MITCHELL A
                                                              AUGUSTA UNIVERSITY Current Research
  
    

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