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SHARE: Cerebellar Degeneration
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            What is cerebellar degeneration?

Cerebellar degeneration is a process in which neurons (nerve cells) in the cerebellum—the area of the brain that controls coordination and balance—deteriorate and die. Diseases that cause cerebellar degeneration also can involve the spinal cord and other areas of the brain, including the medulla oblongata (which is involved in cardiac and respiratory systems), cerebral cortex (involved with thought consciousness, language, emotion, and other processes), and the brain stem.

Cerebellar degeneration may be the result of inherited genetic mutations that alter the normal production of specific proteins that are necessary for the survival of neurons. The disease also can be acquired (non-genetic). Symptoms may include:

A wide-based, unsteady, lurching walk, often accompanied by a tremor in the trunk of the body
	Slow, unsteady and jerky movement of the arms or legs
	Slowed and slurred speech
	Rapid, small movements of the eyes (called nystagmus)Diseases that are specific to the brain, as well as diseases that occur in other parts of the body, can cause neurons to die in the cerebellum. Neurological diseases that feature cerebellar degeneration include:

Stroke, caused by a blood vessel that is either blocked or bleeding
	Cerebellar cortical atrophy, multisystem atrophy, and olivopontocerebellar degeneration – progressive disorders in which cerebellar degeneration is a key feature
	Friedreich ataxia and other spinocerebellar ataxias, which are caused by inherited genetic mutations that result in ongoing loss of neurons in the cerebellum, brain stem, and spinal cord
	Transmissible spongiform encephalopathies (such as Creutzfeldt-Jakob disease), in which abnormal proteins cause inflammation in the brain, including the cerebellum
	Multiple sclerosis, in which damage to the insulating membrane (myelin) that wraps around and protects nerve cells can involve the cerebellumAcquired diseases that can cause cerebellar degeneration include:

Chronic alcohol abuse that leads to temporary or permanent cerebellar damage
	Paraneoplastic disorders, in which cancer in a part of the body produces substances that cause immune system cells to attack neurons in the cerebellum.There is no cure for hereditary forms of cerebellar degeneration. Treatment is usually supportive and is based on the person's symptoms or on disorders that may contribute to the cerebellar degeneration.

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Learn About Clinical Trials

Clinical trials are studies that allow us to learn more about disorders and improve care. They can help connect patients with new and upcoming treatment options.

How can I or my loved one help improve care for people with cerebellar degeneration?

Consider participating in a clinical trial so clinicians and scientists can learn more about cerebellar degeneration. Clinical research uses human volunteers to help researchers learn more about a disorder and perhaps find better ways to safely detect, treat, or prevent disease.

All types of volunteers are needed—those who are healthy or may have an illness or disease—of all different ages, sexes, races, and ethnicities to ensure that study results apply to as many people as possible, and that treatments will be safe and effective for everyone who will use them.

For information about participating in clinical research visitNIH Clinical Research Trials and You. Learn about clinical trials currently looking for people with cerebellar degeneration atClinicaltrials.gov, a database of current and past clinical studies and research results.

Where can I find more information about cerebellar degeneration?

Information may be available from the following resources:

Genetics and Rare Diseases (GARD) Information Center

PubMed
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Order publications from the NINDS Catalog

The NINDS Publication Catalog offers printed materials on neurological disorders for patients, health professionals, and the general public. All materials are free of charge, and a downloadable PDF version is also available for most publications. Health Information
  
    

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      Last reviewed on November 28, 2023
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