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                        Translational Research
SHARE: Active Projects for Partnering
Image
              DTR funding by research area fiscal year 2021
The Division of Translational Research funds programs to support new technology development and treatments for neurological disorders and prepares them for investor funding and corporate partnerships. We provide critical path funding and research resources for biotechnology companies and university researchers to advance early-stage neurological technologies, devices, and therapeutic programs to industry adoption (i.e., investor funding and corporate partnerships). In the last fiscal year, our division funded research projects covering a wide range of modalities (see chart).

Please find below a list of active projects that would welcome new partners.

Full List of Active Projects for Partnering

[contains sortable, interactive table of 205 projects]

Download All OTR Active Projects (Excel)


  File
              This is a preview of the Data Table. Only the first three rows are displayed.
    
    
          Title
                                                                              Indication
                                                                              Institution
                                                                              Modality (Category)
                                                                              PI
                                                                              ProgramEnzyme replacement therapy for GM1 gangliosidosis lysosomal rare disease
                                                              Genetic/Rare Disease
                                                              BIOSTRATEGIES, LC
                                                              Therapeutic - Biologic
                                                              RADIN, DAVID
                                                              Small BusinessRNAi Therapy for Spinocerebellar Ataxia Type 1
                                                              Genetic/rare disease
                                                              CHILDREN'S HOSP OF PHILADELPHIA
                                                              Therapeutic biologic
                                                              DAVIDSON, BEVERLY L
                                                              CREATE BioPeripheral nerve stimulation for amputee pain
                                                              Injury
                                                              SPR THERAPEUTICS, LLC
                                                              Therapeutic/prevention device
                                                              BOGGS, JOSEPH WILDER
                                                              Small BusinessHuman EGFRvIII-specific BiTE for the treatment of Glioblastoma
                                                              Brain tumor
                                                              DUKE UNIVERSITY
                                                              Therapeutic biologic
                                                              SAMPSON, JOHN H
                                                              CREATE BioElectrical impedance myography technology for quantitative, at-home muscle assessment in amyotrophic lateral sclerosis and other neuromuscular disorders.
                                                              Neurodegeneration
                                                              MYOLEX, INC.
                                                              Diagnostic device
                                                              LUPTON, ELMER C
                                                              Small BusinessStem Cells for Treating Acute Stroke
                                                              Stroke
                                                              SANERON CCEL THERAPEUTICS, INC.
                                                              Therapeutic biologic
                                                              KUZMIN-NICHOLS, NICOLE A
                                                              Small BusinessValidation of a novel cortical biomarker signature for pain
                                                              Pain
                                                              UNIVERSITY OF MARYLAND BALTIMORE
                                                              Biomarker
                                                              DA SILVA, JOYCE TEIXEIRA
                                                              HEAL BiomarkersDiscovery of Biomarker Signatures Prognostic for Neuropathic Pain after Acute Spinal Cord Injury
                                                              Pain
                                                              UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
                                                              Biomarker
                                                              HERGENROEDER, GEORGENE W
                                                              HEAL BiomarkersDiscovery and Analytical Validation of Inflammatory Bio-Signatures of the Human Pain Experience
                                                              Pain
                                                              UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
                                                              Biomarker
                                                              PROSSIN, ALAN RODNEY
                                                              HEAL BiomarkersBiomarker Signature to Predict the Persistence of Post-Traumatic Headache
                                                              Pain
                                                              MAYO CLINIC ARIZONA
                                                              Biomarker
                                                              CHONG, CATHERINE DANIELA
                                                              HEAL BiomarkersRepression of Sodium Channels via a Gene Therapy for Treatment of Chronic Neuropathic Pain
                                                              Pain
                                                              NAVEGA THERAPEUTICS, INC.
                                                              Therapeutic biologic
                                                              MORENO, ANA MARIA
                                                              Small BusinessAssessment of Peripherally Circulating Plasma Proteins and Clinical Risks to Differentiate Epileptic Seizure from Psychogenic Nonepileptic Seizure
                                                              Epilepsy
                                                              EVOGEN, INC.
                                                              Biomarker
                                                              GLEDHILL, JOHN
                                                              Small BusinessTargeting lipid rafts for treatment of migraine
                                                              Pain
                                                              RAFT PHARMACEUTICALS, LLC
                                                              Therapeutic biologic
                                                              BACON, KEVIN
                                                              Small BusinessMultielectrode Arrays for Neurotransmitter Detection with Fast Scan Cyclic Voltammetry
                                                              Neuroscience research tool
                                                              MICROPROBES FOR LIFE SCIENCE, INC.
                                                              Research tool
                                                              ZESTOS, ALEXANDROS GEORGE
                                                              Small BusinessPre-clinical evaluation of DT-001, a small molecule antagonist of MD2-TLR4 for utility in the treatment of pain.
                                                              Pain
                                                              DOULEUR THERAPEUTICS, INC.
                                                              Therapeutic small molecule
                                                              YAKSH, TONY L
                                                              Small BusinessOptimization of non-addictive biologics to target sodium channels involved in pain signaling
                                                              Pain
                                                              UNIVERSITY OF CALIFORNIA AT DAVIS
                                                              Therapeutic biologic
                                                              YAROV-YAROVOY, VLADIMIR M
                                                              HEAL Biologics/ Small MoleculesThe Inflammatory Index as a Biomarker for Pain in Patients with Sickle Cell Disease
                                                              Pain
                                                              MEDICAL COLLEGE OF WISCONSIN
                                                              Biomarker
                                                              BRANDOW, AMANDA M
                                                              HEAL BiomarkersSPRINT: Signature for Pain Recovery IN Teens
                                                              Pain
                                                              STANFORD UNIVERSITY
                                                              Biomarker
                                                              SIMONS, LAURA E
                                                              HEAL BiomarkersImplantable Peripheral Nerve Stimulator for Treatment of Phantom Limb Pain
                                                              Pain
                                                              RIPPLE, LLC
                                                              Therapeutic/prevention device
                                                              MCDONNALL, DANIEL
                                                              HEAL DevicesIND-enabling studies on novel Cav3 T-channel modulators for treatment of neuropathic pain
                                                              Pain
                                                              AFASCI, INC.
                                                              Therapeutic/prevention device
                                                              XIE, XINMIN SIMON
                                                              Small BusinessTreatment of Lafora disease with an antibody-enzyme fusion
                                                              Epilepsy
                                                              UNIVERSITY OF KENTUCKY
                                                              Therapeutic - Biologic
                                                              GENTRY, MATTHEW S
                                                              IGNITEIGNITE: Development of novel cyclophilin B/PIKfyve inhibitors for treatment of Malignant Peripheral Nerve Sheath Tumors
                                                              Genetic/rare disease
                                                              SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
                                                              Therapeutic - Small molecule
                                                              OLSON, STEVEN H
                                                              IGNITEAdvancing and calibrating anisotropic diffusion MR imaging brain connectome with Taxon brain network diffusion phantoms
                                                              Neuroscience Research Tool
                                                              PSYCHOLOGY SOFTWARE TOOLS, INC.
                                                              Research tool/assay/animal model
                                                              ZUCCOLOTTO, ANTHONY P
                                                              Small BusinessHigh-content screening for modulators of lamin B1 as a therapeutic target in autosomal dominant leukodystrophy
                                                              Genetic/rare disease
                                                              UNIVERSITY OF PITTSBURGH AT PITTSBURGH
                                                              Therapeutic - Small molecule
                                                              VOGT, ANDREAS
                                                              IGNITESoman-induced neuropathology in Gottingen minipig: large animal model assessment for MCM
                                                              Countermeasures
                                                              GENEVA FOUNDATION
                                                              Research tool/assay/animal model
                                                              LANGE, LUCILLE
                                                              CounterActA Double-Blind, Randomized, Controlled Trial of Epidural Conus Medullaris Stimulation to Alleviate Pain and Augment Rehabilitation in Patients with Subacute Thoracic Spinal Cord Injury (SCI)
                                                              Injury
                                                              DUKE UNIVERSITY
                                                              Therapeutic/prevention device
                                                              LAD, SHIVANAND P
                                                              HEAL DevicesPrehospital Diagnostic Biomarker for Large Vessel Occlusion
                                                              Stroke
                                                              NEURAL ANALYTICS, INC.
                                                              Biomarker
                                                              HAMILTON, ROBERT
                                                              BiomarkersOptimizing oncolytic virus therapy for glioblastoma
                                                              Brain Tumor
                                                              UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
                                                              Therapeutic - Biologic
                                                              KAUR, BALVEEN
                                                              IGNITEThe cyclic redox dye Azure B as a novel cyanide antidote: in vivo efficacy studies
                                                              Countermeasures
                                                              PENNSYLVANIA STATE UNIV HERSHEY MED CTR
                                                              Therapeutic - Small molecule
                                                              HAOUZI, PHILIPPE A
                                                              CounterActCalpastatin Peptide-based Calpain Inhibitor as a Traumatic Brain Injury Therapeutic
                                                              Injury
                                                              NEUROTHERANOSTICS, INC.
                                                              Therapeutic - Biologic
                                                              ANAGLI, JOHN Y
                                                              Small BusinessAn integrated electrical impedance myography platform for neuromuscular disease classification and diagnosis
                                                              Genetic/Rare Disease
                                                              MYOLEX, INC.
                                                              Diagnostic device/biomarker
                                                              LUPTON, ELMER C
                                                              Small BusinessTargeted Therapy for Myasthenia Gravis
                                                              Genetic/Rare Disease
                                                              ARC BIOTECHNOLOGY, LLC
                                                              Therapeutic - Biologic
                                                              KAMINSKI, HENRY J
                                                              Small BusinessPlasma MicroRNA Biomarkers to Guide Rehabilitation Therapy After Stroke
                                                              Stroke
                                                              GEORGETOWN UNIVERSITY
                                                              Biomarker
                                                              EDWARDSON, MATTHEW A
                                                              BiomarkersObjective tests utilizing Vibrational Spectroscopy for Diagnosis and Severity of Fibromyalgia and Related Pain Syndromes
                                                              Pain
                                                              UNIVERSITY OF TEXAS AT AUSTIN
                                                              Biomarker
                                                              HACKSHAW, KEVIN VICTOR
                                                              BiomarkersTherapeutics for Huntingtons Disease
                                                              Neurodegeneration
                                                              SYNTHETIC BIODESIGN, LLC
                                                              Multiple/other
                                                              RUFFNER, DUANE
                                                              Small BusinessA rapid blood test to aid the triage of patients affected by head injuries.
                                                              Injury
                                                              ACCEL DIAGNOSTICS, LLC
                                                              Diagnostic device/biomarker
                                                              GANDINI, ALBERTO
                                                              Small BusinessOPTIMIZATION AND ASSESSMENT OF A BIOLOGIC TO IMPROVE FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY
                                                              Injury
                                                              ALCAMENA STEM CELL THERAPEUTICS, LLC
                                                              Therapeutic - Biologic
                                                              PISARCHIK, ALEXANDER
                                                              Small BusinessInfant NeuroLUX: A Novel Non-invasive Therapeutic Device for Neonatal Hypoxic Brain Injury
                                                              Stroke
                                                              MITOVATION, INC.
                                                              Therapeutic/prevention device
                                                              SANDERSON, THOMAS HUDSON
                                                              Small BusinessAdvanced therapeutic for Parkinsons Disease
                                                              Neurodegeneration
                                                              INHIBIKASE THERAPEUTICS
                                                              Therapeutic - Small molecule
                                                              WERNER, MILTON H
                                                              Small BusinessDrug Eluting Embolization Coils for Improved Treatment of Intracranial Aneurysms
                                                              Stroke
                                                              ANCURE, LLC
                                                              Multiple/other
                                                              BETTINGER, CHRISTOPHER JOHN
                                                              Small BusinessRapid and Effective Localized Neurovascular Cooling Using the Khione Insulative Catheter
                                                              Stroke
                                                              FOCALCOOL, LLC
                                                              Therapeutic/prevention device
                                                              MERRILL, THOMAS L
                                                              Small BusinessHuman Neural Cell Exosomes as a Therapeutic Treatment for Stroke
                                                              Stroke
                                                              ARUNA BIOMEDICAL, INC.
                                                              Therapeutic - Biologic
                                                              BAKER, EMILY W
                                                              Small BusinessUser-driven Retrospectively Supervised Classification Updating (RESCU) system for robust upper limb prosthesis control
                                                              Injury
                                                              INFINITE BIOMEDICAL TECHNOLOGIES, LLC
                                                              Therapeutic/prevention device
                                                              KALIKI, RAHUL REDDY
                                                              DevicesTranscranial focused ultrasound for head and neck cancer pain.  A pilot study
                                                              Multiple/other
                                                              UNIVERSITY OF VIRGINIA
                                                              Therapeutic/prevention device
                                                              ELIAS, WILLIAM JEFFREY
                                                              HEAL DevicesNovel monoclonal antibody for single dose treatment of acute CNS injury
                                                              Injury
                                                              ONCOSYNERGY, INC.
                                                              Therapeutic - Biologic
                                                              CARBONELL, ANNE-MARIE
                                                              Small BusinessiPSC-derived neurovascular tissue model of cerebral amyloiad angiopathy
                                                              Neurodegeneration
                                                              VANDERBILT UNIVERSITY
                                                              Research tool/assay/animal model
                                                              LIPPMANN, ETHAN
                                                              IGNITEMulti-Omic Biomarkers for Neuropathic Pain Secondary to Chemotherapy
                                                              Pain
                                                              CLEVELAND CLINIC LERNER COM-CWRU
                                                              Biomarker
                                                              ROTROFF, DANIEL
                                                              HEAL BiomarkerUltra-low attachment coatings to maintain CSF shunt patency
                                                              Genetic/Rare Disease
                                                              INNOVATIVE SURFACE TECHNOLOGIES, INC.
                                                              Therapeutic/prevention device
                                                              TATON, KRISTIN S
                                                              Small BusinessAntioxidant enzyme-loaded Pro-NP for treatment of TBI.
                                                              Injury
                                                              PROTRANSIT NANOTHERAPY, LLC
                                                              Therapeutic - Biologic
                                                              MADSEN, GARY LEONARD
                                                              Small BusinessAdvancing SRX246 to Commericialization
                                                              Neurodegeneration
                                                              AZEVAN PHARMACEUTICALS, INC.
                                                              Therapeutic/prevention device
                                                              BROWNSTEIN, MICHAEL J
                                                              Small BusinessRapid, Multiplexed, Idealized Antiepileptic Drug Monitoring
                                                              Epilepsy
                                                              ELECTRONIC BIOSCIENCES, INC.
                                                              Therapeutic/prevention device
                                                              SCHIBEL, ANNA
                                                              Small BusinessCryopreserved preparations of male and female brain cells to study gender-related issues
                                                              Multiple/Other
                                                              SPOT CELLS, LLC
                                                              Research tool/assay/animal model
                                                              KIEDROWSKI, LECH
                                                              Small BusinessEliminating the human factor from stereotaxic surgeries
                                                              Multiple/Other
                                                              POPNEURON LTD.
                                                              Research tool/assay/animal model
                                                              KLUG, ACHIM
                                                              Small BusinessEpiZode: Noninvasive Seizure Screening in Preclinical Models of Epilepsy
                                                              Epilepsy
                                                              SIGNAL SOLUTIONS, LLC
                                                              Research tool/assay/animal model
                                                              SUNDERAM, SRIDHAR
                                                              Small BusinessRefinement of a rapid saliva miRNA diagnostic test for concussion
                                                              Injury
                                                              QUADRANT BIOSCIENCES, INC.
                                                              Diagnostic device/biomarker
                                                              LEVITSKIY, DAVID
                                                              Small BusinessTransposon Engineered B Cell Therapy for Hunter Syndrome
                                                              Genetic/Rare Disease
                                                              IMMUSOFT CORPORATION
                                                              Therapeutic - Biologic
                                                              HAMPE, CHRISTIANE S
                                                              Small BusinessDeveloping Drug-like Small Molecules that Target Toxic Repeat RNAs to Alleviate Myotonic Dystrophy Type 1-derived Mis-Splicing
                                                              Genetic/Rare Disease
                                                              NYMIRUM, INC.
                                                              Therapeutic - Small molecule
                                                              KIMSEY, ISAAC J
                                                              Small BusinessSelective actin remodeling of sensory neurons for acute pain management
                                                              Pain
                                                              NEUROCARRUS, INC.
                                                              Therapeutic - Small molecule
                                                              BLUM, PAUL
                                                              Small BusinessDevelopment of a topical fixed-dose combination drug for peripheral neuropathic pain.
                                                              Pain
                                                              WINSANTOR, INC.
                                                              Therapeutic - Small molecule
                                                              HANSEN, ANGELA
                                                              Small BusinessPharmacodynamics and in vivo efficacy of fumarate for mitochondrial disease in vivo
                                                              Neurodegeneration
                                                              UNIVERSITY OF CALIFORNIA AT DAVIS
                                                              Therapeutic - Small molecule
                                                              CORTOPASSI, GINO A
                                                              IGNITEPrognostic biomarkers for high-impact chronic pain: Development and validation
                                                              Pain
                                                              STANFORD UNIVERSITY
                                                              Biomarker
                                                              MACKEY, SEAN C
                                                              HEAL BiomarkerNovel monoclonal antibody for single dose treatment of acute CNS injury
                                                              Injury
                                                              ONCOSYNERGY, INC.
                                                              Therapeutic - Biologic
                                                              CARBONELL, ANNE-MARIE
                                                              Small BusinessAnticonvulsant screening using chronic epilepsy models
                                                              Epilepsy
                                                              MASSACHUSETTS GENERAL HOSPITAL
                                                              Therapeutic - Small molecule
                                                              STALEY, KEVIN J
                                                              IGNITEClinical Testing of an Intracortical Visual Prosthesis System
                                                              Multiple/other
                                                              ILLINOIS INSTITUTE OF TECHNOLOGY
                                                              Therapeutic/prevention device
                                                              TROYK, PHILIP R
                                                              DevicesThe cyclic redox dye Azure B as a novel cyanide antidote: in vivo efficacy studies
                                                              Countermeasures
                                                              PENNSYLVANIA STATE UNIV HERSHEY MED CTR
                                                              Therapeutic - Small molecule
                                                              HAOUZI, PHILIPPE A
                                                              CounterActEarly Feasibility Clinical Study of the VitalFlow Stimulator, an Emergency Treatment for Ischemic Stroke
                                                              Stroke
                                                              NERVIVE, INC.
                                                              Therapeutic/prevention device
                                                              SACRISTAN, EMILIO
                                                              DevicesCombined  Cortical  and  Subcortical  Recording  and Stimulation  as  a  Circuit-Oriented  Treatment  for  Obsessive-Compulsive  Disorder
                                                              Multiple/other
                                                              MASSACHUSETTS GENERAL HOSPITAL
                                                              Therapeutic/prevention device
                                                              DOUGHERTY, DARIN D
                                                              DevicesClinical Translation of Targeted and Noninvasive Ultrasonic Propofol Uncaging
                                                              Epilepsy
                                                              STANFORD UNIVERSITY
                                                              Therapeutic/prevention device
                                                              AIRAN, RAAG D
                                                              DevicesDevelopment of Therapeutic Antibody for Traumatic Brain Injury
                                                              Injury
                                                              BETH ISRAEL DEACONESS MEDICAL CENTER
                                                              Therapeutic - Biologic
                                                              ZEIDEL, MARK L
                                                              CREATE BioNeurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy
                                                              Epilepsy
                                                              MAYO CLINIC ROCHESTER
                                                              Therapeutic/prevention device
                                                              WORRELL, GREGORY A
                                                              DevicesDual Lead Thalamic DBR-DBS Interface for Closed Loop Control of Severe Essential Tremor
                                                              Neurodegeneration
                                                              UNIVERSITY OF FLORIDA
                                                              Therapeutic/prevention device
                                                              OWEISS, KARIM G
                                                              DevicesClinical Translation of Ultrasonic Ketamine Uncaging for Non-Opioid Therapy of Chronic Pain
                                                              Pain
                                                              STANFORD UNIVERSITY
                                                              Therapeutic/prevention device
                                                              AIRAN, RAAG D
                                                              HEAL DevicesDevelopment of cellular HTS for 20S proteasome enhancers
                                                              Neurodegeneration
                                                              MICHIGAN STATE UNIVERSITY
                                                              Therapeutic - Small molecule
                                                              TEPE, JETZE J
                                                              IGNITEBlood test to aid treatment decisions for perinatal asphyxiation
                                                              Injury
                                                              MESO SCALE DIAGNOSTICS, LLC
                                                              Biomarker
                                                              CAMPBELL, CHRISTOPHER T
                                                              BiomarkersSlack Potassium Channel Inhibitors for the Treatment of Childhood Epilepsies
                                                              Epilepsy
                                                              VANDERBILT UNIVERSITY
                                                              Therapeutic - Small molecule
                                                              WEAVER, C DAVID
                                                              IGNITEPharmacokinetic assessment of peptide-based therapy HV-3 for the treatment of Huntingtons disease
                                                              Neurodegeneration
                                                              JANUSQ, LLC
                                                              Therapeutic - Biologic
                                                              SCHILB, ANDREW LORING
                                                              Small BusinessDevelopment of selective calpain-1 inhibitors for chronic pain
                                                              Pain
                                                              1910 GENETICS INC.
                                                              Therapeutic - Biologic
                                                              NWANKWO, JENNIFER O
                                                              Small BusinessDevelopment of a novel analgesic for mixed inflammatory and neuropathic pain states
                                                              Pain
                                                              ANABIOS CORPORATION
                                                              Therapeutic - Small molecule
                                                              GHETTI, ANDREA
                                                              Small BusinessExploring Antisense Oligonucleotides as a potential therapy for Autosomal Dominant Leukodystrophy
                                                              Genetic/rare disease
                                                              UNIVERSITY OF PITTSBURGH AT PITTSBURGH
                                                              Therapeutic - Biologic
                                                              PADIATH, QUASAR S
                                                              IGNITEHumanization of a Notch 3 agonist antibody for pre-clinical development of a CADASIL treatment
                                                              Genetic/rare disease
                                                              SCHEPENS EYE RESEARCH INSTITUTE
                                                              Therapeutic - Biologic
                                                              ARBOLEDA-VELASQUEZ, JOSEPH
                                                              CREATE BioExtracellular RNA biomarkers of myotonic dystrophy type 1
                                                              Genetic/rare disease
                                                              MASSACHUSETTS GENERAL HOSPITAL
                                                              Biomarker
                                                              WHEELER, THURMAN M
                                                              BiomarkersStimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI.
                                                              Injury
                                                              UNIVERSITY OF CALIFORNIA LOS ANGELES
                                                              Therapeutic/prevention device
                                                              LU, DANIEL
                                                              DevicesClinical Validation of Serum Neurofilament Light as a Biomarker of Traumatic Axonal Injury
                                                              Injury
                                                              UNIVERSITY OF PENNSYLVANIA
                                                              Biomarker
                                                              DIAZ-ARRASTIA, RAMON
                                                              BiomarkersDevelopment of a Novel Chemokine Receptor Antagonist Peptide as a Non-Opioid Treatment for Relief of Chronic Pain
                                                              Pain
                                                              CREATIVE BIO-PEPTIDES, INC.
                                                              Therapeutic - Biologic
                                                              RUFF, MICHAEL R
                                                              Small BusinessNINDS CREATE DISCOVERY: Development of dendrimer-N-acetylcysteine for the treatment of neonatal brain injury
                                                              Injury
                                                              JOHNS HOPKINS UNIVERSITY
                                                              Therapeutic - Biologic
                                                              RANGARAMANUJAM, KANNAN
                                                              CREATE BioClosed-Loop Micromagnetic Neuromodulation as a Non-Opioid Treatment for Neuropathic Pain.
                                                              Pain
                                                              QUANTUM NANOSTIM
                                                              Therapeutic/prevention device
                                                              REILLY, THOMAS
                                                              Small BusinessPreclinical Development of VERSAMAB-101 for Spinal Cord Injury
                                                              Injury
                                                              VERSAPEUTICS INC
                                                              Therapeutic - Biologic
                                                              SUN, MIAO
                                                              Small BusinessDevelopment of gene therapy product for treating MPS IIIB
                                                              Genetic/Rare Disease
                                                              NEUROGT, INC.
                                                              Therapeutic - Biologic
                                                              FU, HAIYAN
                                                              Small BusinessExplore Slow-Release Formulation of a Peptide Therapeutic for Migraine
                                                              Pain
                                                              ACHERX
                                                              Therapeutic - Biologic
                                                              SOARES, CHRISTOPHER JOSEPH
                                                              Small BusinessIncreasing NF1 Expression as a Treatment for NF1 Haploinsufficiency
                                                              Genetic/Rare Disease
                                                              INFIXION BIOSCIENCE, INC.
                                                              Therapeutic - Small molecule
                                                              SARNOFF, HERB
                                                              Small BusinessHigh-throughput Screen for Discovery of Ciliary Neurotrophic Factor (CNTF) Receptor Agonists for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
                                                              Neurodegeneration
                                                              MAYO CLINIC  JACKSONVILLE
                                                              Therapeutic - Small molecule
                                                              ROSSOLL, WILFRIED
                                                              IGNITENovel Antidotes for H2S Poisoning
                                                              Countermeasures
                                                              MASSACHUSETTS GENERAL HOSPITAL
                                                              Therapeutic - Small molecule
                                                              ICHINOSE, FUMITO
                                                              CounterACTDrug Discovery for Spinocerebellar Ataxia, using Novel Fluorescence Technology Targeting ?-III-Spectrin
                                                              Neurodegeneration
                                                              UNIVERSITY OF MINNESOTA
                                                              Therapeutic - Small molecule
                                                              HAYS, THOMAS S
                                                              IGNITEEvaluating the Blood-Brain Barrier Bioavailability and in vivo Efficacy Potential of a Novel TAK1 Inhibitor Targeting Chronic Pain
                                                              Pain
                                                              EYDIS BIO, INC.
                                                              Therapeutic - Biologic
                                                              SCARNEO, SCOTT
                                                              Small BusinessA Novel RNA Therapeutics Platform to Treat Facioscapulohumeral Muscular Dystrophy  and other Neuromuscular Disorders
                                                              Genetic/Rare Disease
                                                              MIRECULE, INC.
                                                              Therapeutic - Biologic
                                                              SALEH, ANTHONY D
                                                              Small BusinessProbe for Quantitative Fluorescence. Phase 2
                                                              Brain Tumor
                                                              INSIGHT SURGICAL TECHNOLOGIES, LLC
                                                              Therapeutic/prevention device
                                                              ROBERTS, DAVID W
                                                              Small BusinessImplantable Recording and Integrated Stimulation (IRIS) device for cortical experiments
                                                              Neuroscience Research Tool
                                                              RIPPLE, LLC
                                                              Research tool/assay/animal model
                                                              WILDER, ANDREW
                                                              Small BusinessCentral Vein Sign: A Diagnostic Biomarker in Multiple Sclerosis
                                                              Multiple Sclerosis
                                                              CLEVELAND CLINIC LERNER COM-CWRU
                                                              Biomarker
                                                              ONTANEDA, DANIEL
                                                              BiomarkersEvaluation of Novel Dually Targeted Kinase Inhibitors for Therapy of Adult and Pediatric High-Grade Glioma
                                                              Brain Tumor
                                                              UNIVERSITY OF TX MD ANDERSON CAN CTR
                                                              Therapeutic - Small molecule
                                                              CHANDRA, JOYA
                                                              IGNITEPIKFYVE antagonism as a therapy for C9ORF72-ALS/FTD
                                                              Neurodegeneration
                                                              ACURASTEM, INC.
                                                              Therapeutic - Small molecule
                                                              ALWORTH, SAMUEL V
                                                              Small BusinessDeve inlopment of A High-Throughput Screen for Identification of Targeted Therapies in Brainstem Tumors with the H3K27M Mutation
                                                              Brain Tumor
                                                              MAYO CLINIC ROCHESTER
                                                              Therapeutic - Small molecule
                                                              DANIELS, DAVID
                                                              IGNITEPreclinical Development of Antisense Oligonucleotide Therapy for Spinocerebellar Ataxia Type 3
                                                              Neurodegeneration
                                                              UNIVERSITY OF MICHIGAN AT ANN ARBOR
                                                              Therapeutic - Biologic
                                                              MCLOUGHLIN, HAYLEY SARAH
                                                              CREATE BioCommercialization Readiness Pilot (CRP) to maximize vamorolone international labeling and sales
                                                              Genetic/Rare Disease
                                                              REVERAGEN BIOPHARMA, INC.
                                                              Therapeutic - Small molecule
                                                              HOFFMAN, ERIC P
                                                              Small BusinessEpilepsy Seizure Detection with Innovative Tripolar EEG (tEEG)
                                                              Epilepsy
                                                              CREMEDICAL CORPORATION
                                                              Therapeutic/prevention device
                                                              BESIO, WALTER GRANT
                                                              DevicesNoninvasive, wireless thermal sensors for the quantitative monitoring of ventricular shunt function in patients with hydrocephalus
                                                              Genetic/rare disease
                                                              RHAEOS, INC.
                                                              Therapeutic/prevention device
                                                              SOMERA, ANNA LISA
                                                              DevicesNovel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication
                                                              Countermeasures
                                                              UNIVERSITY OF CALIFORNIA AT DAVIS
                                                              Therapeutic - Small molecule
                                                              LEIN, PAMELA J
                                                              CounterACTActigraphy Enhanced Clinical Chronic Lower Back Pain Management
                                                              Pain
                                                              ARBOR MEDICAL INNOVATIONS, LLC
                                                              Therapeutic/prevention device
                                                              KRUGER, GRANT H
                                                              DevicesNovel Counteract Agents To Reduce Mortality And Morbidity Following Organophosphate Status Epilepticus
                                                              Countermeasures
                                                              VIRGINIA COMMONWEALTH UNIVERSITY
                                                              Therapeutic - Small molecule
                                                              DELORENZO, ROBERT JOHN
                                                              CounterACTClosed Loop Deep Brain Stimulation for Parkinsons Disease
                                                              Neurodegeneration
                                                              UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
                                                              Therapeutic/prevention device
                                                              STARR, PHILIP ANDREW
                                                              DevicesScalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous Potentials
                                                              Neurodegeneration
                                                              DUKE UNIVERSITY
                                                              Therapeutic/prevention device
                                                              TURNER, DENNIS ALAN
                                                              DevicesDevelopment of Novel Intra-aneurysmal Rapid Occlusion Device
                                                              Stroke
                                                              NEUROGAMI MEDICAL, INC.
                                                              Therapeutic/prevention device
                                                              HEBERT, STEPHEN J
                                                              Small BusinessPlasma metabolite and proteome signatures for migraine classification
                                                              Pain
                                                              BRIGHAM AND WOMEN'S HOSPITAL
                                                              Biomarker
                                                              CHASMAN, DANIEL IAN
                                                              BiomarkersIdentification and verification of S-nitroysylated proteins in bodily fluids as biomarkers for Parkinsons disease and Lewy body dementia
                                                              Neurodegeneration
                                                              SCRIPPS RESEARCH INSTITUTE, THE
                                                              Biomarker
                                                              NAKAMURA, TOMOHIRO
                                                              BiomarkersCatheter for Large Volume Intraparenchymal Brain Therapies
                                                              Multiple/Other
                                                              CREOSALUS, INC.
                                                              Therapeutic/prevention device
                                                              ABRAMOV, VASILIY
                                                              Small BusinessNoninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinsons Disease
                                                              Neurodegeneration
                                                              UNIVERSITY OF ALABAMA AT BIRMINGHAM
                                                              Therapeutic/prevention device
                                                              WALKER, HARRISON CARROLL
                                                              DevicesAdvanced Development of Drugs to Mitigate Parathion Intoxication
                                                              Countermeasures
                                                              RBHS-SCHOOL OF PUBLIC HEALTH
                                                              Therapeutic - Small molecule
                                                              LASKIN, JEFFREY D
                                                              CounterACTAnalytical Validation of Tau and P-Tau as acute and subacute prognostic biomarkers for complicated mild TBI
                                                              Injury
                                                              UNIVERSITY OF FLORIDA
                                                              Biomarker
                                                              WANG, KEVIN KA WANG
                                                              BiomarkersDeep cerebellar electrical stimulation for post-stroke motor recovery
                                                              Stroke
                                                              CLEVELAND CLINIC LERNER COM-CWRU
                                                              Therapeutic/prevention device
                                                              MACHADO, ANDRE GUELMAN
                                                              DevicesEducational Program on Translating Neural Medical Devices
                                                              Multiple/Other
                                                              UNIVERSITY OF MINNESOTA
                                                              Training
                                                              JOHNSON, MATTHEW DOUGLAS
                                                              TrainingDevelopment of IM Formulation of (2S,3S)-SPD for Nerve Agent Seizures
                                                              Countermeasures
                                                              UNIVERSITY OF CALIFORNIA AT DAVIS
                                                              Therapeutic - Small molecule
                                                              ROGAWSKI, MICHAEL A
                                                              CounterACTSynthetic hydrogels for biomanufacturing of iPSC-derived neural cells for precision medicine
                                                              multiple/other
                                                              STEM PHARM, INC.
                                                              Research tool/assay/animal model
                                                              LEBAKKEN, CONNIE S
                                                              Small BusinessDevelopment of S-PCT3010 to treat Parkinsons Disease
                                                              Neurodegeneration
                                                              POLYCORE THERAPEUTICS, LLC
                                                              Therapeutic - Small molecule
                                                              BECK, KELLY A
                                                              Small BusinessImproved Therapeutics for the Resurrection of the Aged Form of  Acetylcholinesterase
                                                              Countermeasures
                                                              OHIO STATE UNIVERSITY
                                                              Therapeutic - Small molecule
                                                              HADAD, CHRISTOPHER M
                                                              CounterACTCentral thalamic stimulation for traumatic brain injury
                                                              Injury
                                                              WEILL MEDICAL COLL OF CORNELL UNIV
                                                              Therapeutic/prevention device
                                                              SCHIFF, NICHOLAS D
                                                              DevicesNovel pediatric anticonvulsants for nerve agents
                                                              Countermeasures
                                                              TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
                                                              Therapeutic - Small molecule
                                                              REDDY, DOODIPALA SAMBA
                                                              CounterACTNetwork Pharmacology for Epilepsy Prevention
                                                              Epilepsy
                                                              PREVEP, INC.
                                                              Therapeutic - Small molecule
                                                              KLEIN, PAVEL
                                                              Small BusinessHigh-Resolution, Spinal Cord Stimulation for Non-Opioid Treatment of Neuropathic Pain
                                                              Pain
                                                              MICRO-LEADS, INC.
                                                              Therapeutic/prevention device
                                                              MCLAUGHLIN, BRYAN L
                                                              HEAL DevicestPA and NGF therapy for stroke
                                                              Stroke
                                                              HUMAN CELL CO
                                                              Therapeutic - Biologic
                                                              JEONG, SOON SEOG
                                                              Small BusinessAutomation of Extracorporeal Filtration of Subarachnoid Hemorrhage via Spinal Catheter
                                                              Stroke
                                                              MINNETRONIX, INC.
                                                              Therapeutic/prevention device
                                                              MCCABE, AARON RICHARD
                                                              Small BusinessKinase activation in multiple system atrophy
                                                              Neurodegeneration
                                                              INHIBIKASE THERAPEUTICS
                                                              Research tool/assay/animal model
                                                              WERNER, MILTON H
                                                              Small BusinessReal-time three-dimensional spinal navigation system for bedside lumbar puncture placement
                                                              Multiple/other
                                                              RIVANNA MEDICAL, LLC
                                                              Diagnostic device
                                                              MAULDIN, FRANK WILLIAM
                                                              Small BusinessMitofusin agonists to prevent Charcot-Marie-Tooth disease 2A
                                                              Genetic/Rare Disease
                                                              MITOCHONDRIA IN MOTION, INC.
                                                              Therapeutic - Biologic
                                                              DORN, GERALD W
                                                              Small BusinessTemporal Biomarker-Powered Immunotherapy Targeting GFAP for Traumatic Brain Injury
                                                              Injury
                                                              GRYPHON BIO, INC.
                                                              Therapeutic - Biologic
                                                              HASKINS, WILLIAM E
                                                              Small BusinessHBI-002 to Treat Parkinsons Disease
                                                              Neurodegeneration
                                                              HILLHURST BIOPHARMACEUTICALS, INC.
                                                              Therapeutic - Small molecule
                                                              GOMPERTS, EDWARD
                                                              Small BusinessEnabling rapid and effective stroke thrombectomy procedures from a Transradial approach:  Combining introducer sheath, guide catheter, and distal access catheter into a single device.
                                                              Stroke
                                                              CONWAY MEDICAL LLC
                                                              Therapeutic/prevention device
                                                              KALLMES, DAVID F
                                                              Small BusinessNeupron: A Neuroprotective Agent for Treating Acute Spinal Cord Injury
                                                              Injury
                                                              AXONEURAL THERAPEUTICS, INC.
                                                              Therapeutic - Small molecule
                                                              LABHASETWAR, VINOD D
                                                              Small BusinessPlug-and-Play High-Order B0 Shimming for Reliable Temporal Lobe Epilepsy Magnetic Resonance Spectroscopic Imaging
                                                              Epilepsy
                                                              LUCIDITY MEDICAL, LLC
                                                              Diagnostic device
                                                              YANG, HSIN-JUNG
                                                              Small BusinessSelection & Optimization of a Therapeutic Protein for Acute Ischemic Stroke Functional Recovery
                                                              Stroke
                                                              STREAM BIOMEDICAL, INC.
                                                              Therapeutic - Biologic
                                                              ADKISSON, HUSTON DAVIS
                                                              Small BusinessInvestigation of the Cortical Communication (CORTICOM) System
                                                              Injury
                                                              JOHNS HOPKINS UNIVERSITY
                                                              Therapeutic/prevention device
                                                              CRONE, NATHAN E
                                                              DevicesPreparing for IND-enabling safety studies for a potent and efficient neuroprotective drug.
                                                              Stroke
                                                              NEUREXIS THERAPEUTICS, INC.
                                                              Therapeutic - Biologic
                                                              GOFORTH, ROBYN
                                                              Small BusinessAccuGyd: Accurate Guidance for MRI-Guided Minimally Invasive Neurosurgery
                                                              Multiple/other
                                                              IMGGYD LLC
                                                              Therapeutic/prevention device
                                                              OAKES, TERRENCE R
                                                              Small BusinessPre-clinical evaluation of a rationally designed nanotherapeutic for Huntingtons disease
                                                              Neurodegeneration
                                                              NEURANO BIOSCIENCE
                                                              Therapeutic - Small molecule
                                                              MOLOKANOVA, ELENA
                                                              Small BusinessCircular mimics of Iron-response elements to inhibit ferroptosis
                                                              Neurodegeneration
                                                              CHIMERNA THERAPEUTICS INC.
                                                              Therapeutic - Biologic
                                                              PICKERING, BRIAN FREDERICK
                                                              Small BusinessDevelopment and clinical assessment of a robust, 3D printed titanium, myoelectric powered prosthetic digit system
                                                              Injury
                                                              POINT DESIGNS, LLC
                                                              Therapeutic/prevention device
                                                              SLIKER, LEVIN
                                                              Small BusinessSensiTrak: Automated Assessment of Forelimb Sensation
                                                              Neuroscience Research Tool
                                                              VULINTUS, LLC
                                                              Research tool/assay/animal model
                                                              SLOAN, ANDREW MICHAEL
                                                              Small BusinessOptimization of a Gene Therapy for Chronic Pain in Human DRGs
                                                              Pain
                                                              NAVEGA THERAPEUTICS, INC.
                                                              Therapeutic - Biologic
                                                              MORENO, ANA MARIA
                                                              Small BusinessSelective Androgen Receptor Degraders (SARDs) as new therapeutics for spinal and bulbar muscular atrophy (SBMA)
                                                              Genetic/Rare Disease
                                                              ONCTERNAL THERAPEUTICS, INC.
                                                              Therapeutic - Biologic
                                                              KAUFMANN, GUNNAR JOERG FLORIS
                                                              Small BusinessClinical Evaluation of NoGo Trap Therapy in Chronic SCI
                                                              Injury
                                                              RENETX BIO, INC.
                                                              Therapeutic - Biologic
                                                              SMITH, ERIKA
                                                              Small BusinessNovel Water-Soluble Adjunct Anticonvulsants for Nerve Agents
                                                              Countermeasures
                                                              TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
                                                              Therapeutic - Small molecule
                                                              REDDY, DOODIPALA SAMBA
                                                              CounterACTDevelopment of a non-opioid chemogenetic therapy for chronic neuropathic pain
                                                              Pain
                                                              CODA BIOTHERAPEUTICS, INC.
                                                              Therapeutic - Small molecule
                                                              KERAVALA, ANNAHITA
                                                              Small BusinessMimicking synuclein toxicity in plant cells to identify novel neuroprotective leads
                                                              Neurodegeneration
                                                              NAPROGENIX, INC
                                                              Therapeutic - Small molecule
                                                              LITTLETON, JOHN M
                                                              Small BusinessAlgorithm for the Real-Time Detection of Absence Seizures from Oculometric Data
                                                              Epilepsy
                                                              EYSZ, INC.
                                                              Therapeutic/prevention device
                                                              KUPERMAN, RACHEL
                                                              Small BusinessCirculating Organ-enriched microRNAs as biomarkers of Rett Syndrome
                                                              Genetic/Rare Disease
                                                              DIAMIR, LLC
                                                              Diagnostic device/biomarker
                                                              UMANSKY, SAMUIL R
                                                              Small BusinessPudendal neuromodulation for urinary and fecal incontinence and sphincter dyssynergia
                                                              Injury
                                                              DIGNIFY THERAPEUTICS, LLC
                                                              Therapeutic/prevention device
                                                              THOR, KARL B
                                                              Small BusinessGeneration of Tissue Engineered Nerve Grafts from GalSafe Porcine Neurons
                                                              Injury
                                                              AXONOVA MEDICAL, LLC
                                                              Therapeutic - Biologic
                                                              KATIYAR, KRITIKA
                                                              Small BusinessA youth-specific helmet for preventing traumatic brain injury
                                                              Injury
                                                              SAVIOR BRAIN INC.
                                                              Therapeutic/prevention device
                                                              CAMARILLO, DAVID
                                                              Small BusinessAnalgesic Drug for Local Delivery by Fluoroscopy
                                                              Pain
                                                              INTERVENTIONAL ANALGESIX, INC.
                                                              Therapeutic - Small molecule
                                                              BEUTLER, ANDREAS S
                                                              Small BusinessDevelopment of Fluorescent Probes for Highlighting Nerves During Image Guided Surgeries
                                                              Multiple/other
                                                              ALUME BIOSCIENCES, INC.
                                                              Research tool/assay/animal model
                                                              WHITNEY, MICHAEL A
                                                              Small BusinessSpinal Fiber Optic Monitoring
                                                              Injury
                                                              UT SOUTHWESTERN MEDICAL CENTER
                                                              Diagnostic device
                                                              FLOYD, THOMAS F
                                                              DevicesMicroelectrode Array Insertion System using Ultrasonic Vibration to Improve Insertion Mechanics, Reduce Tissue Dimpling and Trauma, and Improve Placement Precision in the Neocortex
                                                              multiple/other
                                                              ACTUATED MEDICAL, INC.
                                                              Therapeutic/prevention device
                                                              MULVIHILL, MAUREEN L
                                                              Small BusinessOmniphobic cerebral shunt to eliminate clogging and dysfunction
                                                              Genetic/Rare Disease
                                                              FREEFLOW MEDICAL DEVICES, LLC
                                                              Therapeutic/prevention device
                                                              BANDYOPADHYAY, SAIBAL
                                                              Small BusinessDevelopment of a novel therapeutic for treatment of white matter injury in premature infants
                                                              Injury
                                                              TELLUS THERAPEUTICS, INC.
                                                              Therapeutic - Biologic
                                                              KRALIC, JASON
                                                              Small BusinessPHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for SmallBusiness Innovation Research Grant Applications (Parent Small Business [R43/R44] ClinicalTrial Not Allowed
                                                              Neurodegeneration
                                                              CUTANEOUS NEURODIAGNOSTICS, LLC
                                                              Diagnostic device/biomarker
                                                              LEVINE, TODD
                                                              Small BusinessDefining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain Stimulation
                                                              Genetic/rare disease
                                                              UNIVERSITY OF FLORIDA
                                                              Therapeutic/prevention device
                                                              OKUN, MICHAEL S
                                                              DevicesAcute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy
                                                              Epilepsy
                                                              UNIVERSITY OF HOUSTON
                                                              Therapeutic/prevention device
                                                              INCE, NURI FIRAT
                                                              DevicesThin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of Epilepsy
                                                              Epilepsy
                                                              UNIVERSITY OF CALIFORNIA, SAN DIEGO
                                                              Therapeutic/prevention device
                                                              DAYEH, SHADI
                                                              Devices20-HETE Formation Inhibitors in Cardiac Arrest
                                                              Stroke
                                                              UNIVERSITY OF PITTSBURGH AT PITTSBURGH
                                                              Therapeutic - Small molecule
                                                              HURYN, DONNA M
                                                              IGNITEDevelopment of a CCKBR-targeting scFv as Therapy for Chronic Pain Patients
                                                              Pain
                                                              UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
                                                              Therapeutic - Biologic
                                                              WESTLUND-HIGH, KARIN N
                                                              HEAL Biologics/Small MoleculesDisease Modifying Analgesia with CA8 Gene Therapy
                                                              Pain
                                                              UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
                                                              Therapeutic - Biologic
                                                              LEVITT, ROY C
                                                              HEAL Biologics/Small MoleculesNovel, non-opioid, non-addictive intrathecal therapy for the treatment of chronic pain
                                                              Pain
                                                              CENTREXION THERAPEUTICS CORPORATION
                                                              Therapeutic - Small molecule
                                                              CAMPBELL, JAMES N
                                                              HEAL Biologics/Small MoleculesDevelopment of Nav1.7 Monoclonal Antibodies for Treating Pain
                                                              Pain
                                                              INTEGRAL MOLECULAR
                                                              Therapeutic - Biologic
                                                              RUCKER, JOSEPH BENJAMIN
                                                              Small BusinessTargeting the neuropilin-1 receptor (NRP-1)/VEGF-A axis for neuropathic pain
                                                              Pain
                                                              REGULONIX, LLC
                                                              Therapeutic - Small molecule
                                                              KHANNA, RAJESH
                                                              Small BusinessBrain-cell penetrating antibodies for treatment of progressive multiple sclerosis
                                                              Multiple Sclerosis
                                                              ABZYME THERAPEUTICS, LLC
                                                              Therapeutic - Biologic
                                                              TRAN, HIEP T
                                                              Small BusinessDevelopment of a stem cell platform for the treatment of neurodegenerativemicrogliopathies
                                                              Genetic/Rare Disease
                                                              NOVOGLIA, INC.
                                                              Therapeutic - Biologic
                                                              HASSELMANN, JONATHAN
                                                              Small BusinessDifferential diagnosis of Parkinsons and multiple system atrophy in non-human primate models using a novel a-synuclein retinal contrast agent and AI-assisted analytics
                                                              Neurodegeneration
                                                              AMYDIS DIAGNOSTICS, INC.
                                                              Biomarker
                                                              SARRAF, STELLA
                                                              Small BusinessA device to prevent Sudden Unexpected Death in Epilepsy (SUDEP)
                                                              Epilepsy
                                                              SOTERYA, INC.
                                                              Therapeutic/prevention device
                                                              NGUYEN, JUSTIN KE
                                                              Small BusinessNanO2 as a Cerebroprotectant in a tMCAO Stroke Model in Mice
                                                              Stroke
                                                              NUVOX PHARMA, LLC
                                                              Therapeutic - Small molecule
                                                              UNGER, EVAN CHARLES
                                                              Small BusinessThe first adaptable, 3D-formfitting microelectrode array for organoid-based models of neurological and neurodegenerative diseases
                                                              Neuroscience Research Tool
                                                              BMSEED, LLC
                                                              Research tool/assay/animal model
                                                              GRAUDEJUS, OLIVER
                                                              Small BusinessPreclinical development of a novel therapeutic for Parkinsons disease
                                                              Neurodegeneration
                                                              SINOPIA BIOSCIENCES, INC.
                                                              Therapeutic - Small molecule
                                                              BORDBAR, AARASH
                                                              Small BusinessLong acting and peripherally restricted kappa-opioid receptor agonists for acute migraine treatment
                                                              Pain
                                                              PEPTIDE LOGIC, LLC
                                                              Therapeutic - Biologic
                                                              RIVIERE, PIERRE
                                                              Small BusinessNoninvasive challenge-free widely-accessible oxygen extraction fraction mapping
                                                              Multiple/Other
                                                              MEDIMAGEMETRIC, LLC
                                                              Diagnostic device
                                                              DORFMAN, GARY
                                                              Small BusinessTowards a Virtual Biopsy: An improved multimodal imaging biomarker to guide treatment decisions in neuro-oncology by combining advanced tissue microstructure imaging with deep learning
                                                              Brain Tumor
                                                              CORTECHS LABS, INC.
                                                              Biomarker
                                                              WHITE, NATHAN SCOTT
                                                              Small BusinessA Small Molecule Enzyme Replacement for the Treatment of CLN1
                                                              Genetic/Rare Disease
                                                              PALM THERAPEUTICS, INC.
                                                              Therapeutic - Small molecule
                                                              RUDD, ANDREW
                                                              Small BusinessInhibition of NF1 Protein Degradation as a Treatment for NF1 Haploinsufficiency
                                                              Genetic/Rare Disease
                                                              INFIXION BIOSCIENCE, INC.
                                                              Therapeutic - Small molecule
                                                              MATTSON-HOSS, MICHELLE
                                                              Small BusinessDevelopment of a PIKFYVE antisense oligonucleotide treatment for FTD
                                                              Neurodegeneration
                                                              ACURASTEM, INC.
                                                              Therapeutic - Biologic
                                                              ALWORTH, SAMUEL V
                                                              Small BusinessDevelopment of KLS-13019 for Neuropathic Pain
                                                              Pain
                                                              KANNALIFE SCIENCES, INC.
                                                              Therapeutic - Small molecule
                                                              BRENNEMAN, DOUGLAS ERIC
                                                              Small BusinessChemokine-receptor profiling for painful diabetic neuropathy in biological samples from human clinical trials
                                                              Pain
                                                              PLUMERIA THERAPEUTICS, INC.
                                                              Biomarker
                                                              RICHARDSON, THOMAS P
                                                              Small BusinessImmunomodulatory Therapy for Neuropathic Pain
                                                              Pain
                                                              APT THERAPEUTICS, INC.
                                                              Therapeutic - Biologic
                                                              CHEN, RIDONG
                                                              Small BusinessDevelopment of a Synthetic, Cell-Permeable Peptide for the Inhibition of CDK5-p25 Hyperactivity in Amyotrophic Lateral Sclerosis
                                                              Neurodegeneration
                                                              COGENTIS THERAPEUTICS, INC.
                                                              Therapeutic - Biologic
                                                              WERNER, JOHN KENT
                                                              Small BusinessSustained Delivery of Tizanidine for Maintenance Treatment of Moderate to Severe Spasticity
                                                              Multiple/other
                                                              DELPOR, INC.
                                                              Therapeutic/prevention device
                                                              MARTIN, FRANCIS JOSEPH
                                                              Small BusinessMulti-path DCS as a novel non-invasive treatment for amyotrophic lateral sclerosis
                                                              Neurodegeneration
                                                              PATHMAKER NEUROSYSTEMS, INC.
                                                              Research tool/assay/animal model
                                                              AHMED, ZAGHLOUL
                                                              Small BusinessDrug Free Nerve Block Device for the Relief of Pain and Symptoms in Migraines and other Headaches
                                                              Pain
                                                              THERMAQUIL, INC.
                                                              Therapeutic/prevention device
                                                              POPIELARSKI, STEPHEN
                                                              Small BusinessThalamic stimulation to prevent impaired consciousness in epilepsy
                                                              Epilepsy
                                                              YALE UNIVERSITY
                                                              Therapeutic/prevention device
                                                              BLUMENFELD, HAL
                                                              DevicesRNA Targeted Drug Discovery and Development for Parkinson Disease
                                                              Neurodegeneration
                                                              RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL
                                                              Therapeutic - Small molecule
                                                              MOURADIAN, M MARAL
                                                              BPNHigh-Resolution, Spinal Cord Stimulation for Non-Opioid Treatment of Neuropathic Pain
                                                              Pain
                                                              MICRO-LEADS, INC.
                                                              Therapeutic/prevention device
                                                              MCLAUGHLIN, BRYAN L
                                                              DevicesAn Instrument to Assess the Functional Impact of Chronic Pain
                                                              Pain
                                                              BARRON ASSOCIATES, INC.
                                                              Diagnostic device
                                                              CLARK, BRIAN R
                                                              Small BusinessProteolipid protein suppression for Pelizaeus Merzbacher Disease
                                                              Genetic/rare disease
                                                              CASE WESTERN RESERVE UNIVERSITY
                                                              Therapeutic - Biologic
                                                              TESAR, PAUL JOSEPH
                                                              IGNITEDevelopment of MRGPRX1 positive allosteric modulators as non-addictive therapies for neuropathic pain
                                                              Pain
                                                              JOHNS HOPKINS UNIVERSITY
                                                              Therapeutic - Small molecule
                                                              TSUKAMOTO, TAKASHI
                                                              HEAL Biologics/Small MoleculesNovel mGlu5 negative allosteric modulators as first-in-class non-addictive analgesic therapeutics
                                                              Pain
                                                              VANDERBILT UNIVERSITY
                                                              Therapeutic - Small molecule
                                                              ROOK, JERRI MICHELLE
                                                              HEAL Biologics/Small MoleculesDevelopment and Optimization of MNK Inhibitors for the Treatment of Neuropathic Pain
                                                              Pain
                                                              4E THERAPEUTICS INC.
                                                              Therapeutic - Small molecule
                                                              SAHN, JAMES JEFFREY
                                                              HEAL Biologics/Small MoleculesEnhancing Physical Therapy with Brain Stimulation for Treating Postural Instability
                                                              Neurodegeneration
                                                              HIGHLAND INSTRUMENTS, INC.
                                                              Therapeutic/prevention device
                                                              WAGNER, TIMOTHY ANDREW
                                                              Small BusinessNovel non-narcotic analgesic for acute and chronic pain
                                                              Pain
                                                              SOUTH RAMPART PHARMA, LLC
                                                              Therapeutic - Small molecule
                                                              BAZAN, NICOLAS G
                                                              Small BusinessInternal and external validation of a porcine dystrophinopathy model
                                                              Genetic/rare disease
                                                              IOWA STATE UNIVERSITY
                                                              Research tool/assay/animal model
                                                              SELSBY, JOSHUA T
                                                              IGNITEMagnetically Enhanced Diffusion for Intra-Arterial Treatment of Acute Ischemic Stroke
                                                              Stroke
                                                              PULSE THERAPEUTICS, INC.
                                                              Therapeutic/prevention device
                                                              ABENDSCHEIN, DANA R
                                                              Small BusinessModeling West Syndrome to Prevent Neurobehavioral Disabilities
                                                              Epilepsy
                                                              BAYLOR COLLEGE OF MEDICINE
                                                              Research tool/assay/animal model
                                                              SWANN, JOHN WILLIAM
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