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                        NINDS Small Business Program
SHARE: Types of NINDS Small Business Grants
The NINDS Small Business Program has two main component programs: the **Small Business Innovation Research (SBIR) Program** and the **Small Business Technology Transfer (STTR) Program.**Applicant success rates of both the SBIR and STTR programs depend on the budget and the number of applications and can fluctuate from year to year. While the STTR budget is significantly smaller, historically the program gets far fewer applications.

Potential applicants should **send a brief abstract or overview of their technology at least one month before** the SBIR/STTR standard deadline.
	Contact Small Business Program staff at: NINDS_SBIR@ninds.nih.gov
	Further questions? Visit our list of NINDS Small Business FAQS.

Comparing the NIH SBIR and STTR programs
	**Small Business Innovation Research (SBIR)**
			**Small Business Technology Transfer (STTR)****Percent of R&D Budget**
			3.2%
			0.45%**Partnerships**
			Research partnerships are allowed
			Partnership with a non-profit research institution is required (e.g. university)**Work Requirement**
			Small businesses may outsource:

			33% of Phase I research
				50% of Phase II research
			Minimum work requirements:

			40% by small business
				30% by research institution partnerThe remaining work may be done by either or outsourced**Principal Investigator (PI)**
			Primary employment (>50%) must be with the small business
			PI must be employed by either the partnering research institution or small business (minimum 10% effort)

Small Business Program Phases

	*These component programs are structured in three phases, the first two of which are supported using small business program funds.*
	**Phase I**
			A Phase I award helps you focus on the feasibility, technical merit, and commercial potential of your research project.**Phase II**
			A Phase II award lets you continue the research and development efforts initiated in Phase I. Once you’ve reached your Phase I milestones, you can apply for a Phase II award, even before the end of the Phase I award. You may submit your application for a Phase II award up to six receipt dates after your Phase I budget period expires.**Fast-Track**
			The fast-track process allows you to submit both Phase I and Phase II in one application for review. The Fast -Track mechanism can minimize the funding gap between phases but requires a fully developed Phase II application/commercialization plan at the time of submission.**Direct-to-Phase II (SBIR Only)**
			If your project has already demonstrated Phase 1 equivalent feasibility, you can apply for a Direct-to-Phase II award and bypass Phase I.**Phase IIB**
			NINDS offers Phase IIB awards for Phase II projects that require extraordinary time and effort beyond the standard Phase II period of 2 years. Refer to the SEEDPhase IIB FAQsfor more information.**Commercialization Readiness Pillot (CRP) Program**
			The Commercialization Readiness Pilot (CRP) Program provides awarded Phase II or Phase IIB small businesses technical assistance and funding for late-stage development. Read more about theCRP program.

NINDS Small Business Program Mechanisms

	(c*orresponding to the SBIR and STTR Programs above)*
	**R41**: Small Business Technology Transfer (STTR) Grant, Phase I
			Supports cooperative R&D projects between small business concerns and research institutions, limited in time and amount, to establish the technical merit and feasibility of ideas that have potential for commercialization.**R42**: Small Business Technology Transfer (STTR) Grant, Phase II and Fast-Track
			Supports in-depth development of cooperative R&D projects between small business concerns and research institutions, limited in time and amount, for which feasibility has been established in an STTR Phase I project and which have the potential for commercialization.**R43**: Small Business Innovation Research (SBIR) Grant, Phase I
			Supports projects to establish the technical merit and feasibility of R&D ideas which may lead to a commercial product or service and to determine the quality of performance of the small business awardee organization.**R44**: Small Business Innovation Research (SBIR) Grant, Phase II and Fast-Track
			Small Business Innovation Research (SBIR) Grant, Phase II, and Fast-Track: supports in-depth development of R&D ideas for which feasibility was established in Phase I projects and which may ultimately lead to a commercial product or service.**U44**: Cooperative Small Business Awards
			Cooperative Small Business Awards. These are milestone-driven and involve NIH program staff’s participation in developing the project plan, monitoring research progress, and appropriate go/no-go decision-making. See more information on translational research programs which utilize this mechanism.

NINDS Small Business Program Contact Information

Sign up for the Division of Translational Research Listserv to stay up to date with the latest news and funding opportunities!

Emily Caporello, Ph.D.
			Director
			emily.caporello@nih.govTaryn Aubrecht, Ph.D.
			Program Director, Clinical and Research Tools
			taryn.aubrecht@nih.govAnnette Gilchrist, Ph.D.
			Program Director, Drug Development
			annette.gilchrist@nih.govJessica Forbes, Ph.D.
			Health Program Specialist
			jessica.forbes@nih.govSara Sameni, Ph.D.
			Health Program Specialist
			sara.sameni@nih.govSara Dauber, MBA
			Strategic Consultant
			sara.dauber@nih.gov Funding
  
    

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            NINDS Small Business Program
                                                              
                    
                                      Small Business Frequently Asked Questions (FAQs)
    
            Types of NINDS Small Business Grants
    
            Areas of Interest
    
            Submitting a Small Business Application
    
            NINDS SBIR/STTR Funding Decision Process
    
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      Last reviewed on February 20, 2024
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