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Notices**COVID-19 Funding Notices | Approved Initiative Concepts | Research Opportunity Announcements

All NINDS-related notices of funding opportunities (NOFOs), request for applications (RFAs), program announcements (PAs), and other NIH Guide announcements are listed. Search the Closed Opportunities tab to find expired opportunities. Search the Notices tab to find all Notices.

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            Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)  Research Category:Pain  Expiration Date:Monday, September 8, 2025  NOFO Number:PA-23-272  Release Date:Wednesday, August 16, 2023  Notice Type:PA  Funding Opportunity Purpose

    The purpose of the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) award is to enable promising predoctoral students to obtain individualized, mentored research training from outstanding faculty sponsors while conducting dissertation research in scientific health-related fields relevant to the missions of the participating NIH Institutes and Centers. The proposed mentored research training must reflect the candidates dissertation research project and is expected to clearly enhance the individuals potential to develop into a productive, independent research scientist. This Notice of Funding Opportunity (NOFO) is designed specifically for candidates proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial, but does allow candidates to propose research experience in a clinical trial led by a sponsor or co-sponsor.
    Notice of Special Interest (NOSI): Availability of Administrative Supplements for BRAIN Initiative Recipients to Support Resource Dissemination  Expiration Date:Saturday, August 31, 2024  NOFO Number:NOT-EB-23-010  Release Date:Wednesday, August 16, 2023  Notice Type:Notice of Special Interest  Funding Opportunity Purpose

    The goal of this NOSI is to accelerate the scientific impact of the BRAIN Initiative through rapid dissemination of promising technologies and resources to the neuroscience research community. This NOSI will support small dissemination efforts for which a clear value to the identified user group is demonstrated in the application. The proposed work must be within the scope of the original project of the eligible parent award but beyond the original dissemination plans included in the parent application.
    HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional)  Research Category:HEAL Initiative, Pain  Expiration Date:Friday, February 7, 2025  NOFO Number:RFA-NS-24-021  Release Date:Thursday, August 10, 2023  Notice Type:RFA  Funding Opportunity Purpose

    This notice of funding opportunity (NOFO) seeks to support research aimed at holistic understanding of inter-individual or between-person differences in human pain conditions, focusing on Whole Person Health and enhancing pain treatment and management strategies towards personalized pain medicine. The goal of this NOFO is to support studies that focus on the collection of clinical and/or preclinical data to enable evidence-based modeling and understanding of inter-individual differences and/or heterogeneity of pain occurring with use of pain therapy/management, or with conditions such as a second pain condition, a comorbid health condition, a comorbid mental health condition, or conditions of use / misuse of opioids, alcohol or other substances. Applicants are encouraged to develop and implement novel, multidisciplinary research approaches, and include investigators with complementary expertise to fulfill the project and program goals. Input from patients and caregivers on the goals of the project is highly encouraged. Rigorous data-driven and evidence-based research approaches supported under this NOFO are expected to provide better understanding of biological and/or biopsychosocial underpinnings of inter-individual differences, heterogeneity, and stratification of persons with lived pain experience, which would accelerate the development of evidence-based solutions toward precision pain medicine.
    Notice of Special Interest (NOSI): Small Business Initiatives for Innovative tools and Technologies for Improving Outcomes for Maternal Health  Expiration Date:Sunday, September 6, 2026  NOFO Number:NOT-EB-23-005  Release Date:Wednesday, July 26, 2023  Notice Type:Notice of Special Interest  Funding Opportunity Purpose

    The purpose of this trans-NIH Notice of Special Interest (NOSI) is to inform potential applicants that the National Institute of Biomedical Imaging and Bioengineering and participating Institutes and Centers (ICs) invite SBIR/STTR applications to develop technologies or tools to quantitatively predict or indicate an increased risk for maternal morbidity and mortality (MMM). This NOSI is part of the Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE) initiative, which supports research to reduce preventable causes of maternal deaths and improve health for women before, during, and after delivery.
    NIH Blueprint and BRAIN Initiative Program for Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (BP BRAIN-ENDURE) (R25 Clinical Trial Not Allowed)  Expiration Date:Tuesday, February 11, 2025  NOFO Number:RFA-NS-24-014  Release Date:Friday, July 21, 2023  Notice Type:RFA  Funding Opportunity Purpose

    The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH.  The over-arching goal of this NIH Blueprint R25 program is to encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical, behavioral, and clinical research workforce, to pursue further studies or careers in research. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on     Courses for Skills Development, Research Experiences, and Mentoring Activities.The fully integrated educational activities should prepare undergraduate students from diverse backgrounds, including those from groups underrepresented in biomedical and behavioral sciences to enter Ph.D. degree programs in the neurosciences.  To accomplish this goal, this initiative will provide institutional awards to develop neuroscience research education programs comprised of collaborative partnerships integrated across different educational institution types. Each partnership must include: a) one or more institutions that either: 1) have a historical and current mission to educate students from any of the populations that have been identified as underrepresented in biomedical research as defined by the National Science Foundation NSF, see http://www.nsf.gov/statistics/wmpd/) (i.e., African Americans or Blacks, Hispanic or Latino Americans, American Indians, Alaska Natives, Native Hawaiians, U.S. Pacific Islanders, and persons with disabilities) or 2) have a documented track record of recruiting, training and/or educating, and graduating underrepresented students as defined by NSF (see above), which has resulted in increasing the institution's contribution to the national pool of graduates from underrepresented backgrounds who pursue biomedical research careers; b) a research-intensive institution that has an established neuroscience or neuroscience-related program; c) integrated
    Notice of Special Interest: Administrative Supplements for the U.S.-Japan Brain Research Cooperative Program (BRCP) - U.S. Entity (Admin Supp)  Expiration Date:Friday, September 19, 2025  NOFO Number:NOT-NS-23-092  Release Date:Wednesday, July 12, 2023  Notice Type:Notice of Special Interest  Funding Opportunity Purpose

    The National Institutes of Health (NIH) announces the continuation of the U.S. entity of the U.S.-Japan Brain Research Cooperative Program (BRCP). This administrative supplement program will provide funds to currently active research grants that are currently supported by one of the participating NIH Institutes and Centers. This Notice is soliciting administrative supplements for the following mechanisms ONLY: DP1, DP2, DP1, DP2, DP5, R01, R03, R21, R33 , R34, R37, R61, U01, UH2, and UH3.The purpose of the BRCP is to promote scientist exchange, training, and collaborations in basic, translational and clinical research between neuroscientists from the U.S. and Japan.The U.S. entity of the BRCP supports the following activities:1) Visit of U.S. scientists to conduct collaborative research and/or to acquire advanced research skills in Japanese institutions,2) Joint workshops to exchange scientific information and to foster collaborations.
    SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed)  Expiration Date:Sunday, April 6, 2025  NOFO Number:PAR-23-219  Release Date:Wednesday, July 12, 2023  Notice Type:PAR  Funding Opportunity Purpose

    The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications from small business concerns (SBCs) to the newly re-authorized Commercialization Readiness Pilot (CRP) program. The NOFO aims to facilitate the transition of previously or currently funded SBIR and STTR Phase II and Phase IIB projects to the commercialization stage by providing additional support for technical assistance and later stage research and development (R and D) not typically supported through Phase II or Phase IIB grants or contracts. This may include independent replication of key studies, Investigational New Drug (IND)-enabling studies, clinical studies, manufacturing costs, regulatory assistance, or a combination of services. Although a significant amount of the work in a CRP award may be subcontracted to other institutions, the Small Business Concern (SBC) is expected to maintain oversight and management of the R and D throughout the award.
Clinical Trials are not accepted under this NOFO.
    Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed)  Expiration Date:Friday, May 8, 2026  NOFO Number:PA-23-189  Release Date:Wednesday, June 28, 2023  Notice Type:PA  Funding Opportunity Purpose

    The National Institutes of Health (NIH) and the Centers for Disease Control and Prevention hereby notify Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) holding specific types of research grants (activity codes listed above) that funds are available for administrative supplements to enhance the diversity of the research workforce by recruiting and supporting students, postdoctorates, and eligible investigators from diverse backgrounds, including those from groups that have been shown to be underrepresented in health-related research. This supplement opportunity is also available to PD(s)/PI(s) of research grants who are or become disabled and need additional support to accommodate their disability in order to continue to work on the research project.  Administrative supplements must support work within the scope of the original project.
This Notice of Funding Opportunity (NOFO) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial. Applicants to this NOFO are permitted to propose research experience in a clinical trial led by a mentor or co-mentor.
    BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)  Expiration Date:Tuesday, February 9, 2027  NOFO Number:RFA-MH-24-280  Release Date:Friday, June 16, 2023  Notice Type:RFA  Funding Opportunity Purpose

    The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.
    Notice of Special Interest (NOSI): Clinical Studies of CNS Complications in People with HIV  Expiration Date:Tuesday, September 8, 2026  NOFO Number:NOT-MH-23-255  Release Date:Thursday, June 15, 2023  Notice Type:Notice of Special Interest  Funding Opportunity Purpose

    The National Institute of Mental Health is issuing this Notice to highlight interest in Clinical Studies of CNS Complications in People with HIV
  
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