# Gene Expression

The resources listed below are for gene expression-related information relevant to neuroscience research.

## GENSAT

The NIH-sponsored Gene Expression Nervous System Atlas (GENSAT) is a publicly available gene expression atlas of the developing and adult mouse central nervous system with images for ~3,500 genes. Approximately 1,500 BAC transgenic mouse lines are also available with specific green fluorescent protein (GFP) reporter or Cre recombinase driven expression in the nervous system.

Webpage(s):Gene Expression | National Institute of Neurological Disorders and Stroke (nih.gov)GENSAT Brain Atlas of gene expression in EGFP Transgenic MiceMMRRC Repository (‘Advanced Search’, for major collect select ‘GENSAT/NINDS’ and mutation type select ‘Transgenic (cre)’ or ‘Transgenic (BAC)’)

## Allen Mouse and Human Brain Atlas

The Allen Institute for Brain Science is known worldwide for its publicly available resources and tools for neuroscience research. The Allen Mouse and Human Brain Atlases are projects developed to create genome-wide maps for gene expression throughout the adult mouse and human brain, that are free and available online. Started in 2003, the project uses various techniques, including in situ hybridization to map gene expression and create anatomical three-dimensional brain atlases at cellular resolution. As of 2012, seven brain atlases have been published and are publicly available: Mouse Brain Atlas, Human Brain Atlas, Developing Mouse Brain Atlas, Developing Human Brain Atlas, Mouse Connectivity Atlas, Non-Human Primate Atlas, and Mouse Spinal Cord Atlas.

**Webpage(s):**Neuroscience at the Allen Institute | Uncovering mysteries of the brainBrain Map - brain-map.org

## Alliance of Genome Resources

The Alliance of Genome Resources (the Alliance) was established in 2016 and is a consortium of six Model Organism Databases (MODs) and the Gene Ontology Consortium (GOC). The mission of the Alliance is to develop and maintain genome information resources for the scientific community that would facilitate the use of diverse model organisms in scientific research. The Alliance includes six-National Human Genome Research Institute (NHGRI) and one National Heart, Lung, and Blood Institute (NHLBI)-funded MOD/data resources. The six NHGRI-funded MODs/data resources are: Mouse Genome Database, WormBase, Zebrafish Information Network, Saccharomyces Genome Database, Flybase, and the Gene Ontology Consortium. The NHLBI-funded MOD is the Rat Genome Database. The Alliance was established to provide a common infrastructure and searchable software platform for all the NIH-supported MODs/data resources. The Alliance is supported by NIHNHGRI and NHLBI U24HG010859

**Webpage(s):**Home | Alliance of Genome Resources (alliancegenome.org)The Alliance of Genome Resources (Alliance) ConsortiumMGI-Mouse Genome Informatics-The international database resource for the laboratory mouse (jax.org)WormBase : Nematode Information ResourceZFIN The Zebrafish Information NetworkSaccharomyces Genome Database | SGD (yeastgenome.org)FlyBase HomepageGene Ontology ResourceRat Genome Database (mcw.edu)

## Resources and Tools

#### Contacts

Laura Mamounas, Ph.D. | Program Director, NINDSlaura.mamounas@nih.gov