EX-4.1



 Exhibit 4.1 

 
 



 

			
		  	

 C0000000230 M 
 104598 
 SECURITY INSTRUCTIONS ON REVERSE VOIR LES
INSTRUCTIONS DE SECURITE AU VERSO 
 Number 

00000000 
 CSAE_WIP_XCXQ_C02.mtl.pulls/000001/000001/i 

Shares 
 ****0********* 
 *****0******** 

******0******* 
 *******0****** 
 ********0***** 

CUSIP 83578Q209 
 ISIN CA83578Q2099 
 SEE REVERSE FOR CERTAIN
DEFINITIONS 
 sophiris 
 A BRITISH COLUMBIA COMPANY 
 THIS CERTIFIES THAT

 SPECIMEN 
 **SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC.
zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC.
zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC.
zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC.
zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC.
zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC.
zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC.
zero****SPECIMEN83578Q20900000000S0PHIRIS*BIO*INC. zero****SPECIMEN83578Q209 
 IS THE REGISTERED HOLDER OF

 ***0*** 
 **083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero** **083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero**
**083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero** **083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero**
**083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero** **083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero**
**083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero** **083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero**
**083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero** **083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero**
**083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero** **083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero**
**083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero** **083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero**
**083578Q20900000000S0PHIRIS*BIO*INC.zero****083578Q20900000000S0PHIRIS*BIO*INC.zero** 
 FULLY PAID AND
NON-ASSESSABLE COMMON SHARES WITHOUT PAR VALUE IN THE CAPITAL OF 
 SOPHIRIS BIO INC. 

in the Authorized share structure of the above named Company subject to the Articles of the Company transferable on the
Central Securities Register of the Company by the registered holder in person or by attorney duly authorized in writing upon surrender of this certificate properly endorsed. 
 This certificate is not valid unless countersigned by the Transfer Agent and Registrar of the Company. 
 IN WITNESS WHEREOF the Company has caused this certificate to be signed on its behalf by the facsimile signatures of its duly authorized officers, at Vancouver, British Columbia.

 Dated: May 22, 2013 
 President and Chief Executive Officer 

COUNTERSIGNED AND REGISTERED COMPUTERSHARE TRUST COMPANY, N.A. (GOLDEN CO) 

TRANSFER AGENT AND REGISTRAR 
 OR 
 COUNTERSIGNED AND REGISTERED COMPUTERSHARE
TRUST COMPANY OF CANADA (VANCOUVER) (TORONTO) 
 TRANSFER AGENT AND REGISTRAR 

Chief Financial Office 
 By 
 Authorized Officer 

By 
 Authorized Officer 
 The shares represented by this
certificate are transferable at the offices of Computershare Trust Company of Canada in Vancouver, BC; Toronto, ON and Computershare Trust Company, N.A. in Golden, CO. 
 VOID VOID 








													
	The following abbreviations
shall be construed as though the words set forth below opposite each abbreviation were written out in full where such abbreviation appears:
	 	 	  
 TEN COM
	 	  
 -
	 	  
 as tenants in common
	  	  
 (Name) CUST (Name) UNIF
	 	  
 -   (Name) as Custodian for (Name) under the      (State) Uniform Gifts to Minors Act

	 	 	TEN ENT	 	-	 	as tenants by the entireties	  	GIFT MIN ACT (State)	 
	 	 	JT TEN	 	-	 	as joint tenants with rights of survivorship and not as tenants in common	  		 		 	 
	  
 Additional abbreviations may also be used though not in the above list.
  
	 	 

 For value received the undersigned hereby sells, assigns and transfers unto 

 
  
 Insert name and address of transferee 
  

 
  

			
	  
	 	shares

 represented by this certificate and does hereby irrevocably constitute and appoint 

 

			
	  
	 	the attorney

 of the undersigned to transfer the said shares on the books of the Company with full power of substitution in the
premises. 
  

									
	DATED:
                                        
	  	  
	 		  	  
	 	
		  	Signature of Shareholder	 		  	Signature of Guarantor	 	

 Signature Guarantee: 
 The signature on this assignment must correspond with the name as written upon the face of the certificate(s), in every particular, without alteration or enlargement, or any change whatsoever and must be
guaranteed by a major Canadian Schedule I chartered bank or a member of an acceptable Medallion Signature Guarantee Program (STAMP, SEMP, MSP). The Guarantor must affix a stamp bearing the actual words “Signature Guaranteed”. 

In the USA, signature guarantees must be done by members of a “Medallion Signature Guarantee Program” only. 

Signature guarantees are not accepted from Treasury Branches, Credit Unions or Caisses Populaires unless they are members of the Stamp Medallion Program.