EX-4.32





 Exhibit 4.32 

LOCK-UP AND VOTING AGREEMENT 

This Lock-Up and Voting Agreement (this “Lock-Up and
Voting Agreement”) is being delivered to you in connection with an understanding by and between Palisade Bio, Inc., a Delaware corporation (the “Company”), and the person or persons named on the signature pages hereto (collectively,
the “Holder”). 
 Reference is hereby made to the public offering (the “Offering”) of Class A Units
(“Class A Units”) consisting of common stock, par value $0.01 per share, of the Company (the “Common Stock”) and warrants (the “Warrants”) and Class B Units
(“Class B Units”) consisting of Series B Convertible Preferred Stock and Warrants to the public investors in the Offering. 

The Company has filed with the U.S. Securities and Exchange Commission a Registration Statement,
No. 333-265769 on Form S-1 (as the same may be amended from time to time, the “Registration Statement”) for the registration, under the Securities
Act of 1933, as amended (the “Securities Act”) of, among other securities, the Warrants and the Common Stock issuable upon exercise of the Warrants (the “Warrant Shares,” the shares of Common Stock a part of the
Class A Units and the shares of Common Stock issuable upon conversion of the Series B Convertible Preferred Stock, the “Shares”). 

The Holder agrees solely with the Company that, from the public announcement of the final pricing of the Offering (the “Effective
Date”) and ending at 5:00 pm (New York City time) on __________ (such period, the “Restricted Period”), neither the Holder, nor any affiliate of the Holder (“Affiliate”) which (x) had or has knowledge
of the transactions contemplated by the Offering, (y) has or shares discretion relating to the Holder’s investments or trading or information concerning the Holder’s investments, including in respect of the Shares, or (z) is
subject to the Holder’s review or input concerning such Affiliate’s investments or trading (together, the “Holder’s Trading Affiliates”), collectively, shall sell, dispose or otherwise transfer, directly or
indirectly, (including, without limitation, any sales, short sales, swaps or any derivative transactions that would be equivalent to any sales or short positions) on any trading day on the primary trading market of the Company during the Restricted
Period, shares of Common Stock, including the Shares, beneficially owned by the Holder during the Restricted Period (“Restricted Shares”). 

Additionally, the Holder agrees to vote all shares of Common Stock it beneficially owns on and after the Effective Date, including the Shares
as described in the Company’s preliminary proxy statement on Schedule 14A, to be filed by the Company with the U.S. Securities and Exchange Commission following the Effective Date relating to a special meeting of the Company’s
stockholders. For clarity, the Holder’s agreement to vote its shares of Common Stock in accordance with the immediately preceding sentence, does not require the Holder to vote its shares for or against any particular proposal or proposals,
whether or not such proposal or proposals are recommended by the Company’s board of directors. 
 Notwithstanding anything herein to
the contrary, during the Restricted Period, the Holder may, directly or indirectly, sell or transfer all, or any part, of the Restricted Shares to any third party (an “Assignee”) in a transaction which does not need to be reported
on the Nasdaq consolidated tape, without complying with (or otherwise limited by) the restrictions set forth in this Lock-Up and Voting Agreement; provided that, as a condition to any such sale or transfer an
authorized signatory of the Company and such Assignee duly execute and deliver a Lock-Up and Voting Agreement in the form of this Lock-Up and Voting Agreement (an
“Assignee Agreement”, and each such transfer, a “Permitted Transfer”). 












 Any notices, consents, waivers or other communications required or permitted to be given
under the terms of this Lock-Up and Voting Agreement must be in writing and shall be delivered to the Holder at the e-mail address or facsimile number on the signature
page hereto. 
 This Lock-Up and Voting Agreement constitutes the entire agreement among the parties
hereto with respect to the subject matter hereof and supersedes all prior negotiations, letters and understandings relating to the subject matter hereof and are fully binding on the parties hereto. 

This Lock-Up and Voting Agreement may be executed simultaneously in any number of counterparts. Each
counterpart shall be deemed to be an original, and all such counterparts shall constitute one and the same instrument. This Lock-Up and Voting Agreement may be executed and accepted by facsimile or .PDF
signature and any such signature shall be of the same force and effect as an original signature. 
 The terms of this Lock-Up and Voting Agreement shall be binding upon and shall inure to the benefit of each of the parties hereto and their respective successors and assigns. 

This Lock-Up and Voting Agreement may not be amended or modified except in writing signed by each of
the parties hereto. 
 All questions concerning the construction, validity, enforcement and interpretation of this Lockup and Voting
Agreement shall be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law thereof. 

Each party hereto acknowledges that, in view of the uniqueness of the transactions contemplated by this
Lock-Up and Voting Agreement, the other party or parties hereto will not have an adequate remedy at law for money damages in the event that this Lock-Up and Voting
Agreement has not been performed in accordance with its terms, and therefore agrees that such other party or parties shall be entitled to seek specific enforcement of the terms hereof in addition to any other remedy it may seek, at law or in equity.

 The obligations of the Holder under this Lock-Up and Voting Agreement are several and not joint
with the obligations of any other holder of any of the Shares issued under the Registration Statement (each, an “Other Holder”), and the Holder shall not be responsible in any way for the performance of the obligations of any Other
Holder under any such other agreement. Nothing contained in this Lock-Up and Voting Agreement, and no action taken by the Holder pursuant hereto, shall be deemed to constitute the Holder and Other Holders as a
partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Holder and the Other Holders are in any way acting in concert or as a group with respect to such obligations or the transactions contemplated
by this Lock-Up and Voting Agreement and the Company acknowledges that the Holder and the Other Holders are not acting in concert or as a group with respect to such obligations or the transactions contemplated
by this Lock-Up and Voting Agreement or any other agreement. The Company and the Holder confirm that the Holder has independently participated in the negotiation of the transactions contemplated hereby with
the advice of its own counsel and advisors. The Holder shall be entitled to independently protect and enforce its rights, including, without limitation, the rights arising out of this Lock-Up and Voting
Agreement, and it shall not be necessary for any Other Holder to be joined as an additional party in any proceeding for such purpose. 
 The
Company hereby represents and warrants as of the date hereof and covenants and agrees from and after the date hereof that none of the terms offered to any Other Holder with respect to any restrictions on the sale of Class A Units or
Class B Units substantially in the form of this Lock-Up and Voting Agreement (or any amendment, modification, waiver or release thereof) (each an “Other Agreement”), is or will be more
favorable to such Other Holder than those of the Holder and this Lock-Up and Voting Agreement, and the Company agrees to use reasonable best efforts to enforce the terms of any Other













 
Agreement. If, and whenever on or after the date hereof, the Company enters into an Other Agreement with terms that are materially different from this
Lock-Up and Voting Agreement, then (i) the Company shall provide notice thereof to the Holder promptly following the occurrence thereof and (ii) the terms and conditions of this Lock-Up and Voting Agreement shall be, without any further action by the Holder or the Company, automatically amended and modified in an economically and legally equivalent manner such that the Holder shall receive
the benefit of the more favorable terms and/or conditions (as the case may be) set forth in such Other Agreement; provided that, upon written notice to the Company, at any time the Holder may elect not to accept the benefit of any such amended or
modified term or condition, in which event the term or condition contained in this Lock-Up and Voting Agreement shall apply to the Holder as it was in effect immediately prior to such amendment or modification
as if such amendment or modification never occurred with respect to the Holder. The provisions of this paragraph shall apply similarly and equally to each Other Agreement. 

[The remainder of the page is intentionally left blank] 












 The parties hereto have executed this Lock-Up and
Voting Agreement as of the date first set forth above. 
  

			
	PALISADE BIO, INC.
		
	By:	 	 
		 	Name: Thomas M. Hallam, Ph.D.
		 	Title: Chief Executive Officer
		 	E-mail:


 [Signature Page to Palisade Bio, Inc. Lock-Up and Voting
Agreement] 












 The parties hereto have executed this Lock-Up and
Voting Agreement as of the date first set forth above. 
 Agreed to and Acknowledged: 

 

			
	HOLDER
		
	By:	 	 
		 	Name:
		 	Title:
		 	E-mail:
		 	Facsimile:


 [Signature Page to Palisade Bio, Inc. Lock-Up and Voting Agreement]