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# Clinical Research in Type 2 Diabetes

        Studies in humans aimed at the prevention, treatment, and diagnosis of Type 2 Diabetes and the mechanistic aspects of its etiology.    

The Clinical Research in Type 2 Diabetes (T2D) program supports human studies across the lifespan aimed at understanding, preventing and treating T2D. This program includes clinical trials that test pharmacologic, behavioral, surgical or practice-level approaches to the treatment and/or prevention of T2D, including promoting the preservation of beta cell function. Studies may also advance the development of new surrogate markers for use in clinical trials. Studies can be designed to understand the pathophysiology of T2D, including the role of gestational diabetes and metabolic imprinting on the development of T2D, as well as factors influencing the response to treatment. The program also encompasses epidemiologic studies that improve our understanding of the natural history and pathogenesis of T2D, and the development of diagnostic criteria to distinguish type 1 and type 2 diabetes, especially in the pediatric population. The program also supports research to understand and test approaches to accelerate the translation of efficacious interventions into real-world practice and adoption; and to address health equity by reducing health disparities in the incidence and/or clinical outcomes of T2D.

## NIDDK Program Staff

          -  Shavon Artis Dickerson, Dr.P.H., M.P.H.                     Health Equity and Implementation Science                
          -  Henry B. Burch, M.D.                     Clinical studies utilizing existing digital health technology for the prevention and treatment of type 2 diabetes, clinical and basic science studies involving non-neoplastic disorders of the thyroid, clinical studies involving medical and novel dietary treatment of type 2 diabetes.                
          -  Maureen Monaghan Center, Ph.D., CDCES                      Health Psychology, Behavioral Science, Clinical Management of Diabetes                
          -  Jean M. Lawrence, Sc.D., M.P.H., M.S.S.A.                     Type 2 diabetes risk and prevention after gestational diabetes; Studies of adults with diabetes/pre-diabetes using secondary data and observational designs, and natural experiments                
          -  Hanyu Liang, M.D., Ph.D.                     Hepatic Metabolism; Insulin Resistance; Type 2 Diabetes; Obesity; Bariatric Surgery                
          -  Barbara Linder, M.D., Ph.D.                     Type 2 diabetes in children and youth; human studies of metabolic imprinting                
          -  Saul Malozowski, M.D., Ph.D., M.B.A.                     Neuroendocrinology of hypothalamic-pituitary axis, neuropeptide signaling and receptors; hormonal regulation of bone and mineral metabolism; HIV/AIDS-associated metabolic and endocrine dysfunction                
          -  Pamela L. Thornton, Ph.D.                     Health Equity and Translational Research; Centers for Diabetes Translation Research (P30) Program                
          -  Theresa Teslovich Woo, Ph.D.                     Human behavior, developmental cognitive neuroscience, and brain-based mechanisms involved in obesity and diabetes                

## Recent Funding Opportunities

View More Recent Funding Opportunities
-  Posted:4/10/2024PA-24-184  Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Required)  Summary 
-  Posted:4/9/2024PA-24-185  Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Not Allowed)  Summary 
-  Posted:4/2/2024PAR-24-206  Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)  Summary 
-  Posted:4/1/2024RFA-DK-24-002  Adaptation of Diabetes Control Technologies for Older Adults with T1D  (R01 Clinical Trial Optional)  Summary 
-  Posted:4/1/2024RFA-DK-25-008  Diabetes Research Centers (P30 Clinical Trial Optional)  Summary 

View More Recent Funding Opportunities

## Related Links

-   The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)  
 
 
-   The Restoring Insulin Secretion Study (RISE)  
 
 
-   NIDDK Central Repository  
 
 
-   Targeting Inflammation using Salsalate for Type 2 Diabetes (Tinsal) Study  
 
 
-   Vitamin D and Type 2 Diabetes Study (D2d)  
 
 
-   Human Subjects Research  
 
 
-    NIDDK Active Trials in Type 2 Diabetes  
View related clinical trials from ClinicalTrials.gov.
 
-    NIH Study Sections  
    Study sections conduct initial peer review of applications in a designated scientific area.    Visit the NIH’s Center for Scientific Review website to search for study sections.    
 

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## Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.

-  Ancillary Studies to Major Ongoing Clinical Studies  to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.    
-  NIDDK Central Repository  for access to clinical resources including data and biospecimens from NIDDK-funded studies.    
-  NIDDK Information Network (dkNET)  for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.    

## Additional Research Programs

### *Research*Training

NIDDK supports the training and career development of medical and graduate students, postdoctoralfellows, and physician scientists through institutional and individual grants.
Learn about NIDDK Research Training Programs

### Diversity

#### Diversity Programs

The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity Programs

### Small Business

#### Small Business Programs

NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business TechnologyTransfer (STTR) programs.These programs support innovative research conducted by small businesses that has the potential forcommercialization.
Learn about NIDDK Small Business Programs

### Human Subjects*Research*

#### Human Subjects Research

NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
Learn about Human Subjects Research

### Translational*Research*

NIDDK provides funding opportunities and resources to encourage translation of basic discoveriesinto novel therapeutics.
Learn about NIDDK Translational Research Opportunities

## Meetings & Workshops

                                dkNET                            
                                                                                Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.                                                                                                                    

                                NIH Regional Seminars on Program Funding and Grants Administration                            
                                                                                Providing education and training for the next generation of biomedical and behavioral scientist                                                                                                                    

                                NIH Small Business (SBIR & STTR) Engage & Connect                            
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                                View all Meetings & Workshops                            

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          -    NIH Common Fund  
Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.
 
          -    Planning to Apply? Register Early  
Registration is required at eRA Commons and grants.gov and can take 4 weeks.