EX-4.33





 Exhibit 4.33 

[Form of Series B Preferred Stock Certificate] 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO THE
CORPORATION OR THE TRANSFER AGENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF THE HOLDER OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO THE HOLDER, OR TO SUCH OTHER ENTITY AS IS
REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF HAS AN INTEREST HEREIN. TRANSFERS OF THIS GLOBAL SECURITY
SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO NOMINEES OF DTC OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE. 
 THE CORPORATION
IS AUTHORIZED TO ISSUE MORE THAN ONE CLASS OF STOCK AND MORE THAN ONE SERIES OF ITS CLASS OF PREFERRED STOCK. THE CORPORATION WILL FURNISH WITHOUT CHARGE TO EACH STOCKHOLDER WHO SO REQUESTS THE POWERS, DESIGNATIONS, PREFERENCES AND RELATIVE
PARTICIPATING, OPTIONAL OR OTHER SPECIAL RIGHTS OF EACH CLASS OF STOCK OR SERIES THEREOF AND THE QUALIFICATIONS, LIMITATIONS OR RESTRICTIONS OF SUCH PREFERENCES AND/OR RIGHTS. 

Incorporated under the laws of the State of Delaware 

Certificate Number: 1 
 Initial Number of Shares of Series B
Convertible Preferred Stock: 
 CUSIP 

ISIN 
 PALISADE BIO, INC.

 Palisade Bio, Inc. (the “Corporation”) hereby certifies that CEDE & Co. (the “Holder”) is
the registered owner of                          fully paid and non-assessable shares of the Corporation’s designated
Series B Convertible Preferred Stock, par value $0.01 per share (the “Series B Preferred Stock”), transferable on the books and records of the Transfer Agent, in person or by a duly authorized attorney, upon surrender of
this certificate duly endorsed or assigned and in proper form for transfer. 
 This Certificate and the shares represented hereby are issued
and shall be held subject to all the provisions of the Amended and Restated Certificate of Incorporation and the Amended and Restated Bylaws of the Corporation and any amendments thereto, including the provisions of the Certificate of Designation of
Preferences, Rights and Limitations, dated                  , 2022, as the same may be amended from time to time (the “Certificate of Designations”).
Capitalized terms used herein but not defined shall have the meaning given them in the Certificate of Designations. 
 The shares of the
Series B Preferred Stock shall be convertible in the manner and accordance with the terms set forth in the Certificate of Designations. 












 Reference is hereby made to the provisions of the Series B Preferred Stock set forth in
the Certificate of Designations, which provisions shall for all purposes have the same effect as if set forth at this place. 
 Upon receipt
of this executed certificate, the Holder is bound by the Certificate of Designations and is entitled to the benefits thereunder. 
 Unless
the Transfer Agent has properly countersigned, these shares of the Series B Preferred Stock shall not be entitled to any benefit under the Certificate of Designations or be valid or obligatory for any purpose. 

IN WITNESS WHEREOF the said Corporation has caused this Certificate to be signed by its duly authorized officers as of
                 , 2022. 
  

			
	By:	 	 
	Name: Thomas M. Hallam, Ph.D.
	Title:   Chief Executive Officer


 COUNTERSIGNATURE 

These are shares of the Series B Convertible Preferred Stock referred to in the within-mentioned Certificate of Designations. 

Dated:                         

 American Stock Trust & Transfer Company, 
 as Transfer
Agent 
  

			
		
	By:	 	 
	Name:
	Title: