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*** Text Omitted and Filed Separately
Pursuant to a Confidential Treatment Request
Under 17 C.F.R. §§ 200.80(b)(4)
and 240.24b-2
 
        1.
    
    All capitalized terms not defined in this Third Amendment shall have the meaning given
to them in the Agreement.2.
    
    Section 3.5 of the Agreement is hereby amended to add the following sentence to the end
of Section 3.5:For clarification, Sublicense Royalties exclude any payments made to Epimmune (a) for the
purchase of equity securities at fair market value or as part of a strategic relationship
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involving significant intellectual property rights of
Epimmune in addition to the Patent Rights, or (b) as funding at cost for research and development activities currently being
conducted by Epimmune personnel.3.
    
    Section 3.5 of the Agreement is hereby amended to include the following additional
paragraph at the end of the Section:
 3.5.1
    
    Sublicense Royalties for Innogenetics Sublicense. Pursuant to Section 2.2
hereof, Epimmune has granted a sublicense to Genencor International, Inc., which was
effective as of July 9, 2001, and was assigned by Genencor International, Inc. to
Innogenetics, NV (Innogenetics) on March 30, 2004, as may be amended (the
Innogenetics Sublicense). Pursuant to this Section 3.5 Epimmune and TSRI have agreed
that the following royalty shall be payable on Sublicense Royalties paid to Epimmune
under the Innogenetics Sublicense: (i) Epimmune shall pay to TSRI [...***...] of all
Sublicense Royalties, which are not royalties on Net Sales of Licensed Products,
received by Epimmune pursuant to the Innogenetics Sublicense; and (ii) for Sublicense
Revenues which are royalties on the Net Sales of Licensed Products by Innogenetics or
its sublicensees, Epimmune shall pay (or shall cause Innogenetics to pay) to TSRI an
amount equivalent to [...***...] of what is due to Epimmune from Innogenetics as a royalty
on Net Sales of Licensed Products by Innogenetics and its sublicensees calculated in
accordance with the terms of the Innogenetics Sublicense (but excluding any payment by
Innogenetics to any third party of amounts due under any license agreement between
Epimmune and such third party), without taking into account any offsets or credits
against such amount paid by Innogenetics to Epimmune as a result of the royalty owed to
TSRI, but in no event shall the royalty paid to TSRI on Sublicense Revenues which are
royalties on Net Sales of Licensed Products by Innogenetics and its sublicensees be
less than [...***...] of Net Sales of Licensed Products by Innogenetics and its
sublicensees (calculated in accordance with the terms of the Innogenetics Sublicense).
 4.
    
    Each party for itself and its respective subsidiaries, related entities, predecessors,
successors, heirs, executors, administrators, officers, directors, agents, employees and
assigns (as applicable), fully and forever releases and discharges the other party and its
respective subsidiaries, related entities, predecessors, successors, heirs, executors,
administrators, officers, directors, shareholders, agents, employees and assigns (as
applicable), with respect to any and all claims, obligations, debts, liabilities and causes
of action, of every nature, kind and description, in law, equity or otherwise, whether
known, unknown, suspected, unsuspected, anticipated or unanticipated, including, without
limitation, any right of termination under the Agreement, arising out of or relating to the
failure to have determined the specific royalty percentage under Section 3.5 of the
Agreement with respect to the Innogenetics Sublicense prior to the date of this Amendment
Effective Date, and each party promises and agrees that it will never sue the other or
otherwise institute or participate in any legal or administrative proceedings against the
other with respect to such failure to have determined the specific royalty percentage under
Section 3.5 of the Agreement with respect
 *CONFIDENTIAL TREATMENT
REQUESTED 2




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to the Innogenetics Sublicense prior to the date of this Amendment Effective Date. With
respect to the matters released herein, the parties expressly waive any and all rights and
benefits conferred upon them by statute, if any, or common law principle of similar effect
to the effect that general releases do not extend to unsuspected claims, including statutory
language similar to Section 1542 of the Civil Code of the State of California, which states
as follows:
  TSRI has relied on the representations of Epimmune regarding amounts due to TSRI
under Section 3.5 of the Agreement. If those representations are in error, then
this Section 3 of the Third Amendment shall be rendered null and void ab initio.In addition, if Epimmune fails to make any payments required by Section 3.5 of
the Agreement (and does not cure such failure by making such payment within
thirty (30) days after written notice of the failure from TSRI), this Section 3
of the Third Amendment shall be rendered null and void ab initio.5.
    
    Except as specifically modified or amended hereby, the Agreement as amended by the
First and Second Amendments shall remain in full force and effect and, as so modified or
amended, is hereby ratified, confirmed and approved. No provision of this Third Amendment
may be modified or amended except expressly in writing signed by both parties.6.
    
    In the event of any conflict or inconsistency between the terms of the Agreement as
amended by the First and the Second Amendment, and the terms of this Third Amendment, the
terms of this Third Amendment shall prevail.7.
    
    This Third Amendment, together with the Agreement, the First Amendment, and the Second
Amendment constitutes the entire agreement between the parties with respect to the subject
matter hereof and supersedes any prior written and oral agreements and discussions.8.
    
    This Third Amendment may be executed in counterparts, each of which shall constitute an
original and all of which, when taken together, shall constitute one agreement. This Third
Amendment shall be construed in accordance with, and governed in all respects by, the laws
of the State of California without giving effect to principles of conflicts of laws.9.
    
    This Third Amendment shall terminate ab initioif payment for amounts due as of the
Amendment Effective Date pursuant to Section 3.5 of the Agreement are not received by TSRI
within ten (10) days of the Amendment Effective Date, or by July 31, 2005, whichever is the
first to occur.
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LICENSEE:
    
    
    
    TSRI:Epimmune Inc.
    
    
    
    The Scripps Research Institute/s/ Emile Loria
    
    
    
    /s/ Arnold LaGuardiaEmile Loria, M.D.
President &CEO
    
    
    
    Arnold LaGuardia
Executive Vice PresidentDate: 7/29/05
    
    
    
    Date: 8/1/05
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