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		Search Text: Home/< Back ToThe Science/Muscle Energetics
  Muscle Energetics
    The Muscle Energetics Laboratory, led by Dr. Brian Glancy, focuses on how energy is distributed to sustain contractile power in striated muscle cells.
    On This Page
    
          Dr. Brian Glancy, Ph.D.
  Brian Glancy, Ph.D.
          Senior Investigator
          Email
                                      Profile
      Meet the Team
            Contact us
  Senior Investigator Research Interests
            
  Research Interests
              Skeletal muscle is the most abundant tissue in humans and faces near instantaneous changes in demand for force production lasting from seconds to minutes to hours. Initiating and maintaining muscle contraction requires rapid, coordinated movement of signals and material within and among various structures located throughout the relatively large muscle cell. The Muscle Energetics Laboratory focuses on the energy distribution aspect of continued muscle contraction, deficits in which have been implicated in many pathologies including diabetes, cardiovascular disease, muscular dystrophy, and aging. In particular, we aim to determine how mitochondrial and contractile networks are optimized as part of the integrated muscle cell to maintain energy homeostasis during the large change in energy demand caused by the onset of muscle contraction. Ongoing efforts are centered around the structure, function, composition, and developmental regulation of mitochondrial and contractile networks with the goal of gaining better control of and understanding the functional consequences of altering spatial relationships within the muscle energy distribution system.Volume Viewer 7aMuscle Structure 2DMuscle Interior Image
  Videos

            A fly-through rendering of the mitochondrial network within an oxidative mouse skeletal muscle cell. Mitochondria are colored according to their location relative to the adjacent contractile structures.
			Fly-through rendering of the interior structures of a newborn mouse skeletal muscle highlighting cell and organelle membrane as well as myosin filaments.3D rendering of the interior of a mouse retina mitochondrion. Outer membrane (transparent), inner boundary membrane (transparent), inner membrane cristae (magenta), matrix (yellow), and nucleoids (blue) are shown.
			3D rendering of the Z-disk sheets (light green) within the jump muscle of the fruit fly, Drosophila melanogaster. Individual z-disks (various colors) and contractile sarcomeres (magenta) are also shown.3D rendering of the branching contractile structures within a newborn mouse skeletal muscle. Each color represents an individual myofibril segment.  The cell membrane (green) and a nucleus (cyan) are also shown.
			3D rendering of the interior of a newborn mouse skeletal muscle. Mitochondria (red), sarcotubular network (green), lipid droplets (yellow), cell membranes (white), and myosin filaments (blue) are shown.
Images






          Mitochondrial Donut
      
        Click the image to expand
    Mitochondrial Donut


        
            Electron microscopy image of a mitochondrion with a donut hole (cyan) as well as sarcoplasmic reticulum (magenta), transverse tubules (orange), and contractile A-bands (green), I-bands (red), and Z-disks (blue) from a mouse glycolytic skeletal muscle.


                      Mito Fingerprint
      
        Click the image to expand
    Mito Fingerprint


        
            3D rendering of the interior of a mouse skeletal muscle mitochondrion. Mitochondrial outer membrane (red) and inner membrane cristae (green) are shown.


                      SR Mito Cut Through
      
        Click the image to expand
    SR Mito Cut Through


        
            3D rendering of mitochondria (various colors) and the sarcotubular network (green) in an oxidative mouse skeletal muscle.


                      Newborn Mouse RBCs
      
        Click the image to expand
    Newborn Mouse RBCs


        
            3D rendering of red blood cells (various colors) within a skeletal muscle capillary of a newborn mouse. The vesicles (upper), mitochondria (middle), and endoplasmic reticulum (lower) within each cell are shown.


                      Drosophila Mito Networks
      
        Click the image to expand
    Drosophila Mito Networks


        
            3D rendering of four different types of mitochondrial networks in the adult muscles of the fruit fly, Drosophila melanogaster. Leg muscle (upper left), jump muscle (upper right), direct flight muscle (bottom right), and indirect flight muscle (bottom left) mitochondrial networks are shown.
      Mitochondrial Donut


                      
Mito Fingerprint


                      
SR Mito Cut Through


                      
Newborn Mouse RBCs


                      
Drosophila Mito Networks
Featured Publications
                Identification of evolutionarily conserved regulators of muscle mitochondrial network organization.
            Authors:P. Katti, P.T. Ajayi, A. Aponte, C. Bleck, B. Glancy
                                                                                                                        
            Nature communications
      
                2022 Nov 04;13(1):6622
        Read Publication
                            
    Related Labs:
                   Muscle Energetics
                      Mitochondrial network configuration influences sarcomere and myosin filament structure in striated muscles.
            Authors:P. Katti, A. Hall, H. Parry, P. Ajayi, Y. Kim, T B. Willingham, C. Bleck, H. Wen, B. Glancy
                                                                                                                        
            Nature communications
      
                2022 Oct 13;13(1):6058
        Read Publication
                      Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms.
            Authors:Ajayi, P. T., Katti, P., Zhang, Y., Willingham, T. B., Sun, Y., Bleck, C. K. E. & Glancy, B.
                                                                                                                        
            Nat Commun
      
                2022 May 13;13(1):
        Read Publication
                      The unified myofibrillar matrix for force generation in muscle
            Authors:Willingham TB, Kim Y, Lindberg E, Bleck CKE, Glancy B.
                                                                                                                        
            Nat Commun. 
      
                2020 Jul 24;11(1):3722
        Read Publication
                      Subcellular Connectomic Analyses of Energy Networks in Striated Muscle.
            Authors:Bleck CKE, Kim Y, Willingham TB, Glancy B.
                                                                                                                        
            Nat Commun.
      
                2018 Nov 30;9(1):5111
        Read Publication
                                View More Publications
  Meet the Team

    Dr. Brian Glancy, Ph.D.

            Brian Glancy, Ph.D.
                Senior Investigator
                Brian Glancy graduated with a B.A. in Sport Science from the University of the Pacific prior to receiving a Master’s degree in Kinesiology and a Ph.D. in Exercise Science from Arizona State University working with Wayne Willis. He was a postdoctoral fellow with Robert Balaban at the National Heart, Lung, and Blood Institute from 2009 to 2016. Dr. Glancy became an Earl Stadtman Investigator at the NIH with a dual appointment between NHLBI and NIAMS in 2016 and became a tenured Senior Investigator in 2023. He is a member of the American College of Sports Medicine and the American Physiological Society.NHLBI Orloff Award 2016: Dr. Brian Glancy

                                View  Glancy's Profile
    
          Contact the lab
    10 Center DrBethesda, MD 20814United States
        Phone:
                    301-496-2679
                Fax:
  Yingfan Zhang
    
            Yingfan Zhang, Ph.D.
        

    Research Fellow

        zhangy4@nhlbi.nih.gov
            Prasanna Katti
    
            Prasanna Katti, Ph.D.
        

    Visiting Fellow

        prasannakatti.katti@nih.gov
            parry
    
            Hailey Parry, Ph.D.
        

    Postdoctoral Fellow

        hailey.parry@nih.gov
        
                    View
                    Hailey's Profile
            Christian Dang
        

    Postbaccalaureate Fellow

        christian.dang@nih.gov
            Margaret Mungai Headshot
    
            Margaret Mungai
        

    Postbaccalaureate Fellow

        margaret.mungai@nih.gov
  
  Alumni
        

Yuho Kim, Ph.D.
        

    Postdoctoral Fellow
                                        2017

      -
            2020
        Yuho Kim, Ph.D. is currently a Assistant Professor  at Department of Physical Therapy and Kinesiology, University of Massachusetts.
      Peter Ajayi
        

    Postbaccalaureate Fellow
                                        2020

      -
            2021
        Peter Ajayi  is currently a Student at Brown University Medical School.
      Brad Willingham, Ph.D.
        

    Postdoctoral Fellow
                                        2017

      -
            2021
        Brad Willingham, Ph.D.  is currently a Clinical Research Scientist at Shepherd Center. Back To Top Link
  

        

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