Exhibit 4.1
 Committed Line Of Credit Note
 
 $7,500,000.00
    
    May 5, 2010
 FOR VALUE RECEIVED BIOCLINICA, INC. and OXFORD BIO-IMAGING RESEARCH, INC. Borrower PNC BANK, NATIONAL ASSOCIATION Bank SEVEN MILLION FIVE HUNDRED
THOUSAND AND NO/100 DOLLARS ($7,500,000.00) Facility
 1. Advances . Letters of Credit provided however Expiration Date
 2. Rate of Interest . Option
 LIBOR Option . plus
 Daily LIBOR Option. plus
  Base Rate plus
 Business Day
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Daily LIBOR Rate minus
 Federal Funds Open Rate
 LIBOR
 LIBOR Interest Period provided that,
 LIBOR Reserve Percentage
 Prime Rate
 Published Rate
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Applicable
Base Rate plus
   3. Interest Rate Election . provided that
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4. Advance Procedures .
 5. Payment Terms .
  6. Late Payments; Default Rate . Late
Charge Default Rate
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7. Prepayment .
 8. Yield Protection; Break Funding Indemnification
 9. Other Loan Documents . Loan Documents
 10. Events of Default . Event of Default Obligor
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11. Power to Confess Judgment . The Borrower hereby empowers any attorney of any court of
record, after the occurrence of any Event of Default hereunder, to appear for the Borrower and,
with or without complaint filed, confess judgment, or a series of judgments, against the Borrower
in favor of the Bank or any holder hereof for the entire principal balance of this Note, all
accrued interest and all other amounts due hereunder, together with costs of suit and an attorneys
commission of the greater of 10% of such principal and interest or $1,000 added as a reasonable
attorneys fee, and for doing so, this Note or a copy verified by affidavit shall be a sufficient
warrant. The Borrower hereby forever waives and releases all errors in said proceedings and all
rights of appeal and all relief from any and all appraisement, stay or exemption laws of any state
now in force or hereafter enacted. Interest on any such judgment shall accrue at the Default Rate.
 No single exercise of the foregoing power to confess judgment, or a series of judgments, shall be
deemed to exhaust the power, whether or not any such exercise shall be held by any court to be
invalid, voidable, or void, but the power shall continue undiminished and it may be exercised from
time to time as often as the Bank shall elect until such time as the Bank shall have received
payment in full of the debt, interest and costs. Notwithstanding the attorneys commission
provided for in the preceding paragraph (which is included in the warrant for purposes of
establishing a sum certain), the amount of attorneys fees that the Bank may recover from the
Borrower shall not exceed the actual attorneys fees incurred by the Bank.
 12. Right of Setoff .
 13. Indemnity . Indemnified Parties
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provided however
 14. Miscellaneous . Notices provided however
 This Note will be interpreted and the
rights and liabilities of the Bank and the Borrower determined in accordance with the laws of the
State where the Banks office indicated above is located, excluding its conflict of laws
rules.
 15. WAIVER OF JURY TRIAL . The Borrower irrevocably waives any and all rights the
Borrower may have to a trial by jury in any action, proceeding or claim of any nature relating to
this Note, any documents executed in connection with this Note or any transaction contemplated in
any of such documents. The Borrower acknowledges that the foregoing waiver is knowing and
voluntary.
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The Borrower acknowledges that it has read and understood all the provisions of this Note,
including the confession of judgment and the waiver of jury trial, and has been advised by counsel
as necessary or appropriate.
 WITNESS
 WITNESS / ATTEST:
    
    
    
    BIOCLINICA, INC./s/ Stephanie F. Later

Print Name: Stephanie F. Later 
Title: Executive Assistant
    
    
    
    By:
    
    /s/ Mark L. Weinstein

Print Name: Mark L. Weinstein 
Title: President & CEOOXFORD BIO-IMAGING RESEARCH, INC./s/ Ted I. Kaminer

Ted I. Kaminer, Vice President
    
    
    
    By:
    
    /s/ Maria Kraus

Maria Kraus, Assistant Secretary
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ANNEX 1
 PRICING GRID
 LIBOR Rate MarginRatio of Total Debt
    
    and Letter of
    
    
    
    Unused Fee on LineLevel
    
    to EBITDA
    
    Credit Fee
    
    Base Rate Margin
    
    of CreditI
    
    Less than or equal 
to 1.0 to 1
    
    175 basis points
(1.75%)
    
    75 basis points
(0.75%)
    
    25 basis pointsII
    
    Greater than 1.0 to 
1 but less than or 
equal to 2.0 to 1
    
    200 basis points
(2.0%)
    
    100 basis points
(1.0%)
    
    35 basis points