# Patent

## Title
Phenylcarboxylic acid derivatives and use thereof for the treatment of diabetes

## Abstract

The invention relates to compounds of general formula (1): in which R1, R2, R3, R4, R5, A, B, D and E are as defined in Claim 1, and also to the preparation process therefor and the therapeutic use thereof. These compounds can be used in the treatment of pathologies associated with hyperglycaemia.

## Background
The present invention relates to aryl carboxylic acid derivatives of the formula (1), which are useful in the treatment of pathologies associated with insulin resistance syndrome.
Insulin resistance is characterised by a reduction in the action of insulin (cf. Presse Médicale, 1997, 26 (No. 14), 671-677) and is involved in a large number of pathological conditions, such as diabetes and more particularly non-insulin-dependent diabetes (type II diabetes or NIDDM), dyslipidaemia, obesity and also certain microvascular and macrovascular complications, for instance arterial hypertension, atherosclerosis, inflammatory processes, macroangiopathy, microangiopathy, retinopathy and neuropathy.
In this respect, reference may be made, for example, to Diabetes, Vol. 37, 1988, 1595-1607; Journal of Diabetes And Its Complications, 1998, 12, 110-119 or Horm. Res., 1992, 38, 28-32.
According to the present invention, the compounds of the formula (1) have hypoglycaemiant activity. They can reduce hyperglycaemia and more particularly the hyperglycaemia of non-insulin-dependent diabetes. The compounds of the invention especially have anti-hyperglycaemic activity.
Patent application EP 0 947 500 discloses two compounds similar in structure to the general formula (1), but do not, however, describe any antidiabetic activity.
The compounds of the invention are of the general formula (1) below:




in which:

B and E each represent a —CH2— group or an oxygen atom;
R1 is chosen without preference from the following groups:

    
    
        H
        (C1-C8)alkyl, optionally substituted by one or more groups chosen independently from halogen, (C1-C5)alkyl, (C1-C5)alkoxy, (C3-C8)cycloalkyl and (C6-C14)aryl
        (C2-C20)alkene optionally substituted by one or more groups chosen independently from halogen, (C1-C5)alkyl, (C1-C5)alkoxy, (C3-C8)cycloalkyl and (C6-C14)aryl
        (C2-C20)alkyne optionally substituted by one or more groups chosen independently from halogen, (C1-C5)alkyl, (C1-C5)alkoxy, (C3-C8)cycloalkyl and (C6-C14)aryl
        (C3-C8)cycloalkyl optionally substituted by one or more groups chosen independently from (C1-C5)alkyl and (C1-C5)alkoxy
        (C3-C8)heterocycle comprising one or more hetero atoms chosen from N, O and S and optionally substituted by one or more groups chosen independently from (C1-C5)alkyl and (C1-C5)alkoxy,
        (C6-C14)aryl(C1-C20)alkyl optionally substituted by one or more groups chosen independently from amino, hydroxyl, thio, halogen, (C1-C5)alkyl, (C1-C5)alkoxy, (C1-C5)alkylthio, (C1-C5)alkylamino, (C6-C14)aryl, (C6-C14)-aryloxy and (C6-C14)aryl(C1-C5)alkoxy;
    
    


Preferably, R1 represents a hydrogen atom;
X represents a group chosen without preference from:

    
    
        amino, hydroxyl, thio, halogen, cyano, nitro, trifluoromethoxy, trifluoromethyl, carboxyl, carboxymethyl or carboxyethyl, (C1-C8)alkyl, (C1-C8)-alkoxy, (C1-C8)alkylthio, (C1-C8)alkylamino, (C6-C14)aryl, (C6-C14)aryl-(C1-C8)sulfonylalkyl, (C6-C14)aryloxy, (C6-C14)aryl(C1-C8)alkoxy, —NHCO—(C1-C8)alkyl, —N—(C1-C8)alkylCO(C1-C8)alkyl, —CO(C1-C8)alkyl, —SO2—(C6-C14)aryl, di(C1-C8)alkylamino, (C3-C8)cycloalkyl or a ketone function;
    
    


Preferably, X represents hydroxyl, halogen, cyano, nitro, trifluoromethoxy, trifluoromethyl, carboxyl, (C1-C8)alkyl, —SO2(C6-C14)aryl, (C1-C8)alkoxy, di-(C1-C8)alkylamino, —NHCO(C1-C8)alkyl, —N—(C1-C8)alkylCO(C1-C8)alkyl, —CO(C1-C8)alkyl, (C6-C14)aryl(C1-C8)alkoxy or a ketone function;
Z represents a group chosen without preference from:

    
    
        (C1-C20)alkyl optionally substituted by one or more groups chosen without preference from X;
        (C2-C20)alkene optionally substituted by one or more groups chosen without preference from X;
        (C2-C20)alkyne optionally substituted by one or more groups chosen without preference from X;
        (C6-C14)aryl, (C6-C14)aryl(C1-C5)alkoxy, (C6-C14)aryloxy and (C6-C14)aryloxy(C1-C5)alkoxy, the aryl group of each of these groups itself possibly being substituted by one or more groups chosen without preference from X; preferably, aryl represents phenyl or naphthyl;
        (C3-C8)cycloalkyl optionally substituted by one or more groups chosen without preference from X, preferably cyclohexyl or cyclopentyl;
        (C3-C8)heterocycle comprising one or more hetero atoms chosen from N, O and S and X substituted by one or more groups chosen without preference from X;
        (C6-C14)aryl(C1-C20)alkyl, (C6-C14)aryl(C2-C20)alkene and (C6-C14)aryl-(C2-C20)alkyne, the aryl group of each of these groups itself possibly being substituted by one or more groups chosen without preference from X;
        (C5-C13)heteroaryl and (C5-C13)heteroaryl(C1-C20)alkyl comprising one or more hetero atoms chosen from N, O and S, the heteroaryl group of each of these groups itself possibly being substituted by one or more groups chosen without preference from X; preferably, heteroaryl represents quinolyl, thiazolyl, thienyl, benzothienyl, quinoxalinyl or furyl;
        (C3-C8)cycloalkyl(C1-C20)alkyl, (C3-C8)cycloalkyl(C2-C20)alkene or (C3-C8)cycloalkyl(C2-C20)alkyne, the cycloalkyl group of each of these groups itself possibly being substituted by one or more groups chosen without preference from X;
    
    


Preferably, Z represents (C1-C20)alkyl, (C6-C14)aryl, (C3-C8)cycloalkyl, (C6-C14)aryl(C1-C20)alkyl or (C5-C13)heteroaryl, each optionally substituted by one or more groups chosen without preference from X, in which X is defined as above;
R2 and R2′ are chosen without preference from the following groups:

    
    
        H
        X,
        Z;
    
    


Preferably, R2 and R2′ represent H;
R3 is chosen without preference from the following groups:

    
    
        H,
        Z;
    
    


Preferably, R3 represents H or (C1-C8)alkyl;
R4 represents a group chosen from:




Preferably, R4 represents




R5 is chosen without preference from Z;

    
    
        Preferably, R5 represents (C1-C20)alkyl, (C6-C14)aryl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C20)alkyl, (C6-C14)aryl(C1-C20)alkyl or (C5-C13)heteroaryl, each optionally substituted by one or more groups chosen without preference from X, in which X is defined as above;
    
    


D represents a single bond or a (C1-C6)alkyl group optionally substituted by one or more groups X or Z;
Preferably, D represents a single bond or an unsubstituted (C1-C6)alkyl group;
A represents a single bond or a (C1-C6)alkyl group optionally substituted by one or more groups X or Z;
Preferably, A represents a single bond;
n and n′ represent an integer chosen independently from 1, 2 and 3,
and also the tautomeric forms, enantiomers, diastereoisomers and epimers, and the pharmaceutically acceptable salts,
with the exception of the compounds for which:

    
    
        -ACOOR1, and —NR3R4 are respectively ortho and para relative to the chain B-D-E, R1=H, A represents a single bond, B=E=CH2, D=single bond, and
    
    


1) R3=H, R4=SO2-Phenyl-Cl(4′), R2=Cl in a meta position relative to the chain B-D-E, or
2) R3=—CH(CH3)2, R4=SO2-Phenyl, R2=CF3 in a meta position relative to the chain B-D-E.
One particular group of compounds of the formula (1) is the group in which the compounds have a general formula (2) or (2′) below in which the group -A-COOR1 is in an ortho or meta position on the ring relative to E.




in which:

R1, R2, R3, R4, A, B, D and E are as defined above.
In the formula (1), if -ACOOR1 is in the para position, preferably —NR3R4 is in the para or meta position relative to the chain B-D-E.
In the formula (1), if -ACOOR1 is in the para position, —NR3R4 is in an ortho position relative to the chain B-D-E, preferably, R2=H and/or
In the formula (1), if -ACOOR1 is in the para position, —NR3R4 is in an ortho position relative to the chain B-D-E, preferably, B-D-E represents an at least 5-membered chain and/or
In the formula (1), if -ACOOR1 is in the para position, —NR3R4 is in an ortho position relative to the chain B-D-E, preferably B and E each represent an oxygen atom.
In the formula (1), if -ACOOR1 is in the para position, —NR3R4 is in an ortho position relative to the chain B-D-E, preferably R4 represents




A particular group of compounds of the formula (1) is the group in which the compounds have a general formula (3) below in which the function NR3R4 is in a meta position on the ring relative to B.




in which R1, R2, R3, R4, A, B, D and E are as defined above.

A particular group of compounds of the formula (1) is the group in which the compounds have a general formula (4) below in which the function NR3R4 is in the para position on the ring relative to B.




in which R1, R2, R3, R4, A, B, D and E are as defined above.

According to one preferred aspect of the invention, the compounds of the formula (1) are those for which B and E both represent a —CH2— group and D represents a single bond or a —CH2 group.
According to one preferred aspect of the invention, the compounds of the formula (1) are those for which B and E both represent an oxygen atom and D represents a —C2H4 group.
According to another preferred aspect of the invention, the compounds of the formula (1) are those for which B and E both represent a —CH2— group, D representing a chain containing 3 carbon atoms.
A particular group of compounds of the formula (1) is the group for which the groups B, D and E taken together constitute an alkylene chain containing at least 5 carbon atoms.
The compounds of the formula (1) may be chosen from:

    4-{2-[2-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-[2-(2-methanesulfonylaminophenyl)ethyl]benzoic acid
    4-{2-[2-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-[2-(2-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
    4-{2-[2-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
    4-[2-(2-benzenesulfonylaminophenyl)ethyl]benzoic acid
    4-{2-[2-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(4-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(4-fluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl]ethyl}-benzoic acid
    4-{2-[2-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(4-methoxy-2,5,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(hexadecane-1-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(3-fluoro-6-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2,3,4,5,6-pentamethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(3-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-(2-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
    4-{2-[2-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[2-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenyl]ethyl}benzoic acid
    4-(2-{2-[(4-acetylaminobenzenesulfonyl)butylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(4-chlorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(4-methoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(2-nitrobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(toluene-4-sulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(3-trifluoromethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(naphthalene-1-sulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(2,5-dimethoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(2,4-dimethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(2-fluorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(2,4-difluorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(4-acetylbenzenesulfonyl)butylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(4-methoxy-2,3,6-trimethylbenzenesulfonyl)amino]phenyl}ethyl)-benzoic acid
    4-(2-{2-[butyl(5-dimethylaminonaphthalene-1-sulfonyl)amino]phenyl}ethyl)-benzoic acid
    4-(2-{2-[butyl(naphthalene-2-sulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(2-acetylamino-4-methylthiazole-5-sulfonyl)butylamino]phenyl}ethyl)-benzoic acid
    4-{2-[2-(benzenesulfonylbutylamino)phenyl]ethyl}benzoic acid
    4-(2-{2-[butyl(2,5-dichlorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(2,4,6-trimethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(4-tert-butylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl((E)-2-phenylethenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(3,4-dimethoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(4-trifluoromethoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(thiophene-2-sulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(5-benzenesulfonylthiophene-2-sulfonyl)butylamino]phenyl}ethyl)-benzoic acid
    4-(2-{2-[butyl(2-trifluoromethoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(4-butoxybenzenesulfonyl)butylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(5-fluoro-2-methylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(2,6-difluorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(4-butylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(3-methoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-{2-[2-(butylpentamethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-(2-{2-[(3,5-bis-trifluoromethylbenzenesulfonyl)butylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(4-propylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(4-isopropylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(3-fluorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(toluene-3-sulfonyl)amino]phenyl}ethyl)benzoic acid
    4-[2-(2-{butyl-[4-(1,1-dimethylpropyl)benzenesulfonyl]amino}phenyl)ethyl]-benzoic acid
    4-(2-{2-[butyl(2-cyanobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(4-ethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[butyl(4-trifluoromethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(4-chlorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(toluene-4-sulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(3-trifluoromethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(naphthalene-1-sulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(2,5-dimethoxybenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(2,4-dimethylbenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(2-fluorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(2,4-difluorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(2-trifluoromethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(4-fluorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(4-acetylbenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(4-methoxy-2,3,6-trimethylbenzenesulfonyl)amino]phenyl}ethyl)-benzoic acid
    4-(2-{2-[heptyl(naphthalene-2-sulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(2-acetylamino-4-methylthiazole-5-sulfonyl)heptylamino]phenyl}ethyl)-benzoic acid
    4-{2-[2-(benzenesulfonylheptylamino)phenyl]ethyl}benzoic acid
    4-(2-{2-[heptyl((E)-2-phenylethenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(3,4-dimethoxybenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(4-trifluoromethoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(quinoline-8-sulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(5-fluoro-2-methylbenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(2,6-difluorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(4-butylbenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(3-methoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(4-propylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(4-isopropylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-(2-{2-[(3-fluorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(toluene-3-sulfonyl)amino]phenyl}ethyl)benzoic acid
    4-[2-(2-{[4-(1,1-dimethylpropyl)benzenesulfonyl]-heptylamino}phenyl)ethyl]-benzoic acid
    4-(2-{2-[(2-cyanobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
    4-(2-{2-[heptyl(4-trifluoromethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
    4-{2-[3-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-[2-(3-methanesulfonylaminophenyl)ethyl]benzoic acid
    4-{2-[3-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-[2-(3-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
    4-{2-[3-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
    4-[2-(3-benzenesulfonylaminophenyl)ethyl]benzoic acid
    4-{2-[3-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2-trifluoro-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(ethanesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-(2-{3-[4-(1,1-dimethylethyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
    4-{2-[3-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(biphenyl-4-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-((E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-[2-(3-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
    4-{2-[3-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-(2-{3-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
    4-{2-[3-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenyl]ethyl}benzoic acid
    4-{2-[4-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-[2-(4-methanesulfonylaminophenyl)ethyl]benzoic acid
    4-{2-[4-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-[2-(4-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
    4-{2-[4-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
    4-[2-(4-benzenesulfonylaminophenyl)ethyl]benzoic acid
    4-{2-[4-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenyl]ethyl}benzoic acid
    4-{2-[4-(4-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(ethanesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid 200
    4-{2-[4-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2,3,4,5,6-pentamethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(3-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    4-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
    4-{2-[4-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(2-methanesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[2-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(2-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[2-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(2-benzenesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[2-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl]ethyl}-benzoic acid
    3-{2-[2-(biphenyl-4-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(2-ethanesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-((E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(hexadecane-1-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(quinoline-8-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(2-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-(2-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
    3-{2-[2-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenyl]ethyl}benzoic acid
    3-{2-[2-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[2-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(3-methanesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[3-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(3-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[3-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(3-benzenesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[3-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl]ethyl}-benzoic acid
    3-{2-[3-(biphenyl-4-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(3-ethanesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[3-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-((E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2,2,2-trifluoroethanesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(quinoline-8-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(3-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[3-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-(2-{3-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
    3-{2-[3-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[3-(7,7-dimethyl-2-oxobicyclo[2,2,1]hept-1-ylmethanesulfonylamino)-phenyl]ethyl}benzoic acid
    3-{2-[4-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(4-methanesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[4-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(4-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[4-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(4-benzenesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[4-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl]ethyl}-benzoic acid
    3-{2-[4-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(4-ethanesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[4-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-((E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(quinoline-8-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    3-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
    3-{2-[4-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenyl]ethyl}benzoic acid
    3-{2-[4-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    3-[2-(4-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
    3-{2-[4-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    3-{2-[4-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl]ethyl}-benzoic acid
    2-{2-[2-(biphenyl-4-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(2-ethanesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-((E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(quinoline-8-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(2-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-(2-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
    2-{2-[2-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(2-methanesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[2-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(2-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[2-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(2-benzenesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[2-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[2-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenyl]ethyl}benzoic acid
    2-{2-[3-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl]ethyl}-benzoic acid
    2-{2-[3-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-((E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(3-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[3-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-(2-{3-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
    2-{2-[3-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(3-methanesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[3-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(3-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[3-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(3-benzenesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[3-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[3-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenyl]ethyl}benzoic acid
    2-{2-[4-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl]ethyl}-benzoic acid
    2-{2-[4-(biphenyl-4-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(4-ethanesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[4-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-((E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(4-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
    2-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
    2-{2-[4-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(4-methanesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[4-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(4-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[4-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
    2-[2-(4-benzenesulfonylaminophenyl)ethyl]benzoic acid
    2-{2-[4-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
    2-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenyl]ethyl}benzoic acid
    2-{3-[2-(4-acetylaminobenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(4-chlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(4-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(2-nitrobenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(toluene-4-sulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(naphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(2-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(2,4-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(4-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl]propyl}-benzoic acid
    2-{3-[2-(biphenyl-4-sulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(4-acetylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(naphthalene-2-sulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]propyl}benzoic acid
    2-[3-(2-benzenesulfonylaminophenyl)propyl]benzoic acid
    2-{3-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(4-isopropylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-((E)-2-phenylethenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(4-carboxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(4-butoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(2,6-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(4-butylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(3-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-[3-(2,3,4,5,6-pentamethylbenzenesulfonylaminophenyl)propyl]benzoic acid
    2-{3-[2-(4-propylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(4-isopropylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(3-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(toluene-3-sulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-acetylaminobenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-chlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-[3-(2-methanesulfonylaminophenyl)propyl]benzoic acid
    3-{3-[2-(4-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(2-nitrobenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(toluene-4-sulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(naphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
    3-[3-(2-phenylmethanesulfonylaminophenyl)propyl]benzoic acid
    3-{3-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(2-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(2,4-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(biphenyl-4-sulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-acetylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-[3-(2-ethanesulfonylaminophenyl)propyl]benzoic acid
    3-{3-[2-(butane-1-sulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(naphthalene-2-sulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]propyl}benzoic acid
    3-[3-(2-benzenesulfonylaminophenyl)propyl]benzoic acid
    3-{3-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-tert-butylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-[3-(2-trifluoromethanesulfonylaminophenyl)propyl]benzoic acid
    3-{3-[2-((E)-2-phenylethenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(thiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(propane-2-sulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-butoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(2,6-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-butylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(3-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-[3-(2-pentamethylbenzenesulfonylaminophenyl)propyl]benzoic acid
    3-{3-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-propylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-isopropylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(3-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(toluene-3-sulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
    3-(3-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}propyl)benzoic acid
    3-{3-[2-(2-cyanobenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-ethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    3-{3-[2-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenyl]propyl}benzoic acid
    4-{3-[2-(4-acetylaminobenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-chlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-[3-(2-methanesulfonylaminophenyl)propyl]benzoic acid
    4-{3-[2-(4-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(2-nitrobenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(toluene-4-sulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(naphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
    4-[3-(2-phenylmethanesulfonylaminophenyl)propyl]benzoic acid
    4-{3-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(2-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(2,4-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(biphenyl-4-sulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-acetylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-[3-(2-ethanesulfonylaminophenyl)propyl]benzoic acid
    4-{3-[2-(butane-1-sulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(naphthalene-2-sulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]propyl}benzoic acid
    4-[3-(2-benzenesulfonylaminophenyl)propyl]benzoic acid
    4-{3-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-tert-butylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-((E)-2-phenylethenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(thiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(propane-2-sulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-butoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(2,6-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-butylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(3-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-[3-(2,3,4,5,6-pentamethylbenzenesulfonylaminophenyl)propyl]benzoic acid
    4-{3-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-propylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-isopropylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(3-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(toluene-3-sulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
    4-(3-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}propyl)benzoic acid
    4-{3-[2-(2-cyanobenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-ethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    4-{3-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{5-[2-(4-acetylaminobenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-chlorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-[5-(2-methanesulfonylaminophenyl)pentyl]benzoic acid
    2-{5-[2-(4-methoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-nitrobenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(toluene-4-sulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(naphthalene-1-sulfonylamino)phenyl]pentyl}benzoic acid
    2-[5-(2-phenylmethanesulfonylaminophenyl)pentyl]benzoic acid
    2-{5-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-fluorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2,4-difluorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-fluorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-acetylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-[5-(2-ethanesulfonylaminophenyl)pentyl]benzoic acid
    2-{5-[2-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(naphthalene-2-sulfonylamino)phenyl]pentyl}benzoic acid
    2-[5-(2-benzenesulfonylaminophenyl)pentyl]benzoic acid
    2-{5-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-tert-butylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(thiophene-2-sulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(quinoline-8-sulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-butoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2,6-difluorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3-methoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-[5-(2-pentamethylbenzenesulfonylaminophenyl)pentyl]benzoic acid
    2-{5-[2-(4-propylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-isopropylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(toluene-3-sulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]pentyl}benzoic acid
    2-(5-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}pentyl)benzoic acid
    2-{5-[2-(2-carboxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-ethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3-methoxybenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-tert-butylbenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3-carboxypropionylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-carboxybutyrylamino)phenyl]pentyl}benzoic acid
    2-(5-{2-[2-(4-chlorophenyl)acetylamino]phenyl}pentyl)benzoic acid
    2-{5-[2-(4-chlorobenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3,4-dichlorobenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2,6-dichlorobenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-carboxyacetylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-fluorobenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3-phenylpropionylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3-methylbutyrylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-phenoxyacetylamino)phenyl]pentyl}benzoic acid
    2-[5-(2-phenylacetylaminophenyl)pentyl]benzoic acid
    2-{5-[2-(2,2-dimeithylpropionylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-methylbenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-methylbenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3,5-difluorobenzoylamino)phenyl]pentyl}benzoic acid
    2-(5-{2-[((1R,2R)-2-phenylcyclopropanecarbonyl)amino]phenyl}pentyl)benzoic acid
    2-{5-[2-(2-ethylhexanoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-ethylbenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3,5-dichlorobenzoylamino)phenyl]pentyl}benzoic acid
    2-(5-{2-[(naphthalene-2-carbonyl)amino]phenyl}pentyl)benzoic acid
    2-{5-[2-(2-benzyloxyacetylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-methoxyacetylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(cyclohexanecarbonylamino)phenyl]pentyl}benzoic acid
    2-[5-(2-butyrylaminophenyl)pentyl]benzoic acid
    2-{5-[2-(cyclopentanecarbonylamino)phenyl]pentyl}benzoic acid
    2-[5-(2-isobutyrylaminophenyl)pentyl]benzoic acid
    2-{5-[2-(2-hydroxyacetylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-phenylbutyrylamino)phenyl]pentyl}benzoic acid
    2-[5-(2-propionylaminophenyl)pentyl]benzoic acid
    2-(5-{2-[2-(4-fluorophenyl)acetylamino]phenyl}pentyl)benzoic acid
    2-{5-[2-((S)-2-hydroxypropionylamino)phenyl]pentyl}benzoic acid
    2-(5-{2-[2-(4-methoxyphenyl)acetylamino]phenyl}pentyl)benzoic acid
    2-{5-[2-(2-ethylbutyrylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-methylpentanoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3-cyclopentylpropionylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-methylbutyrylamino)phenyl]pentyl}benzoic acid
    2-(5-{2-[(quinoxaline-2-carbonyl)amino]phenyl}pentyl)benzoic acid
    2-{5-[2-(2,3-difluorobenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-fluoro-4-trifluoromethylbenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(3-chlorobenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-methoxybenzoylamino)phenyl]pentyl}benzoic acid
    2-[5-(2-benzoylaminophenyl)pentyl]benzoic acid
    2-{5-[2-(3,3-dimethylbutyrylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2-chlorobenzoylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-fluorobenzoylamino)phenyl]pentyl}benzoic acid
    2-(5-{2-[(naphthalene-1-carbonyl)amino]phenyl}pentyl)benzoic acid
    4-{2-[2-(4-acetylaminobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-chlorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(2-methanesulfonylaminophenoxy)ethoxy]benzoic acid
    4-{2-[2-(4-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2-nitrobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(toluene-4-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(3-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(naphthalene-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(2-phenylmethanesulfonylaminophenoxy)ethoxy]benzoic acid
    4-{2-[2-(2,5-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2,4-dimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2,4-difluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(biphenyl-4-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-acetylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(2-ethanesulfonylaminophenoxy)ethoxy]benzoic acid
    4-{2-[2-(butane-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}-benzoic acid
    4-{2-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(naphthalene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenoxy]ethoxy}-benzoic acid
    4-[2-(2-benzenesulfonylaminophenoxy)ethoxy]benzoic acid
    4-{2-[2-(2,5-dichlorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2,4,6-triisopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2,4,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-tert-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-((E)-2-phenylethenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(3,4-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(thiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-carboxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(quinoline-8-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-butoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2,6-difluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(3-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(2-pentamethylbenzenesulfonylaminophenoxy)ethoxy]benzoic acid
    4-{2-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-propylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-isopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(3-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(toluene-3-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-(2-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenoxy}ethoxy)benzoic acid
    4-{2-[2-(2-carboxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2-cyanobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-ethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-chlorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-[2-(4-methanesulfonylaminophenoxy)ethoxy]benzoic acid
    2-{2-[4-(4-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(2-nitrobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(toluene-4-sulfonylamino)phenoxy]ethoxy}benzoic acid
    2-[2-(4-phenylmethanesulfonylaminophenoxy)ethoxy]benzoic acid
    2-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(2-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(2,4-difluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(biphenyl-4-sulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-acetylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-[2-(4-ethanesulfonylaminophenoxy)ethoxy]benzoic acid
    2-{2-[4-(butane-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}-benzoic acid
    2-{2-[4-(naphthalene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenoxy]ethoxy}-benzoic acid
    2-[2-(4-benzenesulfonylaminophenoxy)ethoxy]benzoic acid
    2-{2-[4-(2,5-dichlorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(2,4,6-triisopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-tert-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-((E)-2-phenylethenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(thiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-carboxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-butoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(3-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-[2-(4-pentamethylbenzenesulfonylaminophenoxy)ethoxy]benzoic acid
    2-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-propylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-isopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(3-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(toluene-3-sulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    2-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenoxy}ethoxy)benzoic acid
    2-{2-[4-(2-carboxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(2-cyanobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-ethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    2-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenoxy]ethoxy}benzoic acid
    4-[2-(4-methanesulfonylaminophenoxy)ethoxy]benzoic acid
    4-{2-[4-(4-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(2-nitrobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(toluene-4-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(naphthalene-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(4-phenylmethanesulfonylaminophenoxy)ethoxy]benzoic acid
    4-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(2-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(2,4-difluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(4-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(4-ethanesulfonylaminophenoxy)ethoxy]benzoic acid
    4-{2-[4-(butane-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}-benzoic acid
    4-{2-[4-(5-dimethylaminonaphthalene-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(naphthalene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(4-benzenesulfonylaminophenoxy)ethoxy]benzoic acid
    4-{2-[4-(2,5-dichlorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(2,4,6-triisopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(4-tert-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(4-trifluoromethanesulfonylaminophenoxy)ethoxy]benzoic acid
    4-{2-[4-((E)-2-phenylethenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(thiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(propane-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(2,2,2-trifluoroethanesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(quinoline-8-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(4-butoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(2,6-difluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(4-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(3-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(4-pentamethylbenzenesulfonylaminophenoxy)ethoxy]benzoic acid
    4-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(4-propylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(4-isopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(3-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(toluene-3-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
    4-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenoxy}ethoxy)benzoic acid
    4-{2-[4-(2-cyanobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(4-ethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(3,5-dichloro-2-hydroxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenoxy]ethoxy}benzoic acid
    (2-{2-[4-(4-acetylaminobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(4-chlorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(4-methoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(toluene-4-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(4-fluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(biphenyl-4-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(4-acetylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    {2-[2-(4-ethanesulfonylaminophenoxy)ethoxy]phenyl}acetic acid
    (2-{2-[4-(butane-1-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}-phenyl)acetic acid
    (2-{2-[4-(5-dimethylaminonaphthalene-1-sulfonylamino)phenoxy]ethoxy}phenyl)-acetic acid
    (2-{2-[4-(naphthalene-2-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenoxy]ethoxy}-phenyl)acetic acid
    {2-[2-(4-benzenesulfonylaminophenoxy)ethoxy]phenyl}acetic acid
    (2-{2-[4-(2,5-dichlorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(2,4,6-triisopropylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(4-tert-butylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-((E)-2-phenylethenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)-acetic acid
    (2-{2-[4-(thiophene-2-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    4-{4-[2-(2-carboxymethylphenoxy)ethoxy]phenylsulfamoyl}benzoic acid
    (2-{2-[4-(quinoline-8-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}phenyl)-acetic acid
    (2-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)-acetic acid
    (2-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(2,6-difluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid 1000
    (2-{2-[4-(4-butylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(3-methoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    {2-[2-(4-pentamethylbenzenesulfonylaminophenoxy)ethoxy]phenyl}acetic acid
    (2-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)-acetic acid
    (2-{2-[4-(4-propylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(4-isopropylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(3-fluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(toluene-3-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}phenyl)-acetic acid
    [2-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenoxy}ethoxy)phenyl]-acetic acid
    methyl 2-{4-[2-(2-carboxymethylphenoxy)ethoxy]phenylsulfamoyl}benzoate
    (2-{2-[4-(2-cyanobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(4-ethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    (2-{2-[4-(2-nitrobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
    3-(2-{2-[4-(4-acetylaminobenzenesulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
    3-(2-{2-[4-(4-chlorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-{2-[2-(4-methanesulfonylaminophenoxy)ethoxy]phenyl}propionic acid
    3-(2-{2-[4-(4-methoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(toluene-4-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
    3-(2-{2-[4-(naphthalene-1-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
    3-(2-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(2-fluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(2,4-difluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
    3-(2-{2-[4-(4-fluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(biphenyl-4-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(4-acetylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-{2-[2-(4-ethanesulfonylaminophenoxy)ethoxy]phenyl}propionic acid
    3-(2-{2-[4-(butane-1-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}-phenyl)propionic acid
    3-(2-{2-[4-(5-dimethylaminonaphthalene-1-sulfonylamino)phenoxy]ethoxy}-phenyl)propionic acid
    3-(2-{2-[4-(naphthalene-2-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenoxy]ethoxy}-phenyl)propionic acid
    3-{2-[2-(4-benzenesulfonylaminophenoxy)ethoxy]phenyl}propionic acid
    3-(2-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
    3-(2-(2-[4-(4-tert-butylbenzenesulfonylamino)phenoxy]ethoxyphenyl)propionic acid
    3-(2-{2-[4-((E)-2-phenylethenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
    3-(2-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
    3-(2-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}-phenyl)propionic acid
    3-(2-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
    3-(2-{2-[4-(4-butoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
    3-(2-{2-[4-(2,6-difluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(4-butylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(3-methoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-{2-[2-(4-pentamethylbenzenesulfonylaminophenoxy)ethoxy]phenyl}propionic acid
    3-(2-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}-phenyl)propionic acid
    3-(2-{2-[4-(4-propylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(4-isopropylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(3-fluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(toluene-3-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid methyl 2-(4-{2-[2-(2-carboxy-ethyl)phenoxy]ethoxy}phenylsulfamoyl)benzoate
    3-(2-{2-[4-(4-ethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
    3-(2-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenoxy]ethoxy}phenyl)propionic acid
    3-(2-{2-[4-(2-nitrobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
    4-{2-[2-(2-hydroxybenzoylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(3-methoxybenzoylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-tert-butylbenzoylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(3-carboxypropionylamino)phenoxy]ethoxy}benzoic acid
    4-(2-{2-[2-(4-chlorophenyl)acetylamino]phenoxy}ethoxy)benzoic acid
    4-{2-[2-(4-chlorobenzoylamino)phenoxy]ethoxy}benzoic acid
    4-(2-{2-[(E)-(3-phenylacryloyl)amino]phenoxy}ethoxy)benzoic acid
    4-[2-(2-hexanoylaminophenoxy)ethoxy]benzoic acid
    4-[2-(2-decanoylaminophenoxy)ethoxy]benzoic acid
    4-{2-[2-(2-fluorobenzoylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(3-methylbutyrylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(2-pentanoylaminophenoxy)ethoxy]benzoic acid
    4-{2-[2-(2-phenoxyacetylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(2-phenylacetylaminophenoxy)ethoxy]benzoic acid
    4-{2-[2-(2,2-dimethylpropionylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2-methylbenzoylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-methylbenzoylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(2-nonanoylaminophenoxy)ethoxy]benzoic acid
    4-{2-[2-(3,5-difluorobenzoylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2-methoxybenzoylamino)phenoxy]ethoxy}benzoic acid
    4-(2-{2-[(furan-2-carbonyl)amino]phenoxy}ethoxy)benzoic acid
    4-{2-[2-(2-ethylhexanoylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-ethylbenzoylamino)phenoxy]ethoxy}benzoic acid
    4-(2-{2-[(thiophene-2-carbonyl)amino]phenoxy}ethoxy)benzoic acid
    4-{2-[2-(3-methylbut-2-enoylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2-benzyloxyacetylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2-methoxyacetylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(4-methoxybenzoylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(2-benzoylaminophenoxy)ethoxy]benzoic acid
    4-{2-[2-(3,3-dimethylbutyrylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(2-chlorobenzoylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(3-cyclopentylpropionylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(cyclohexanecarbonylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(3-fluorobenzoylamino)phenoxy]ethoxy}benzoic acid
    4-{2-[2-(3-bromobenzoylamino)phenoxy]ethoxy}benzoic acid
    4-[2-(2-butyrylaminophenoxy)ethoxy]benzoic acid
    4-{2-[2-(cyclopentanecarbonylamino)phenoxy]ethoxy}benzoic acid
    4-(2-{2-[((1S,4R)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl)-amino]phenoxy}ethoxy)benzoic acid

and also the tautomeric forms, enantiomers, diastereoisomers and epimers, and the pharmaceutically acceptable salts.



More preferably, the compounds of the formula (1) according to the invention may be chosen from:

    2-{5-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(quinoline-8-sulfonylamino)phenyl]pentyl}benzoic acid
    2-[5-(2-ethanesulfonylaminophenyl)pentyl]benzoic acid
    2-{5-[2-(2-fluorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-methoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{5-[2-(4-isopropylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
    2-{3-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(naphthalene-2-sulfonylamino)phenyl]propyl}benzoic acid
    2-{3-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
    2-{2-[4-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
    4-{2-[3-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid

and also the tautomeric forms, enantiomers, diastereoisomers and epimers, and the pharmaceutically acceptable salts.



According to the present invention, the alkyl radicals represent saturated hydrocarbon-based radicals, in a straight or branched chain of 1 to 20 carbon atoms and preferably of 1 to 8 carbon atoms.
If they are linear, mention may be made especially of methyl, ethyl, propyl, butyl, pentyl, hexyl, octyl, nonyl, decyl, dodecyl, hexadecyl and octadecyl radicals.
If they are branched or substituted by one or more alkyl radicals, mention may be made especially of isopropyl, tert-butyl, 2-ethylhexyl, 2-methylbutyl, 2-methylpentyl, 1-methylpentyl and 3-methylheptyl radicals.
The alkoxy radicals according to the present invention are radicals of the formula —O-alkyl, the alkyl being as defined above.
Among the Halogen atoms that are more particularly mentioned are fluorine, chlorine, bromine and iodine atoms, preferably fluorine.
The alkenyl radicals represent hydrocarbon-based radicals in a straight or linear chain, and comprise one or more ethylenic unsaturations. Among the alkenyl radicals that may especially be mentioned are allyl or vinyl radicals.
The alkynyl radicals represent hydrocarbon-based radicals, in a straight or linear chain, and comprise one or more acetylenic unsaturations. Among the alkynyl radicals, mention may be made especially of acetylene.
The cycloalkyl radical is a saturated or partially unsaturated, non-aromatic mono-, bi- or tricyclic hydrocarbon-based group of 3 to 8 carbon atoms, especially, such as cyclopropyl, cyclopentyl, cyclohexyl or adamantyl, and also the corresponding rings containing one or more unsaturations.
Aryl denotes a monocyclic or bicyclic hydrocarbon-based aromatic system of 6 to 14 carbon atoms.
Among the aryl radicals that may especially be mentioned are phenyl and naphthyl radicals, more particularly substituted by at least one halogen atom.
Among the -alkylaryl radicals, mention may be made especially of benzyl and phenethyl radicals.
The heteroaryl radicals denote monocyclic or bicyclic aromatic systems of 5 to 13 carbon atoms, comprising one or more hetero atoms chosen from nitrogen, oxygen and sulfur. Among the heteroaryl radicals that may be mentioned are pyrazinyl, thienyl, oxazolyl, furazanyl, pyrrolyl, 1,2,4-thiadiazolyl, naphthyridinyl, pyridazinyl, quinoxalinyl, phthalazinyl, imidazo[1,2-a]pyridine, imidazo[2,1-b]thiazolyl, cinnolinyl, triazinyl, benzofurazanyl, azaindolyl, benzimidazolyl, benzothienyl, thienopyridyl, thienopyrimidinyl, pyrrolopyridyl, imidazopyridyl, benzazaindole, 1,2,4-triazinyl, benzothiazolyl, furanyl, imidazolyl, indolyl, triazolyl, tetrazolyl, indolizinyl, isoxazolyl, isoquinolinyl, isothiazolyl, oxadiazolyl, pyrazinyl, pyridazinyl, pyrazolyl, pyridyl, pyrimidinyl, purinyl, quinazolinyl, quinolinyl, isoquinolyl, 1,3,4-thiadiazolyl, thiazolyl, triazinyl, isothiazolyl and carbazolyl, and also the corresponding groups derived from their fusion or from fusion with the phenyl nucleus. The preferred heteroaryl groups comprise thienyl, quinoxalinyl, furanyl, quinolinyl and thiazolyl, and groups derived from fusion with a phenyl nucleus, and more particularly benzothienyl.
The heterocyclic radicals denote saturated monocyclic or bicyclic systems of 3 to 8 carbon atoms, comprising one or more hetero atoms chosen from N, O and S. Among the heterocyclic groups, mention may be made especially of epoxyethyl, oxiranyl, aziridinyl, tetrahydrofuranyl, dioxolanyl, pyrrolidinyl, pyrazolidinyl, imidazolidinyl, tetrahydrothiophenyl, dithiolanyl, thiazolidinyl, tetrahydropyranyl, dioxanyl, morpholinyl, piperidyl, piperazinyl, tetrahydrothiopyranyl, dithianyl, thiomorpholinyl, dihydrofuranyl, 2-imidazolinyl, 2,3-pyrrolinyl, pyrazolinyl, dihydrothiophenyl, dihydropyranyl, pyranyl, tetrahydropyridyl, dihydropyridyl, tetrahydropyrimidinyl and dihydrothiopyranyl, and the corresponding groups derived from fusion with a phenyl nucleus.
The expression “pharmaceutically acceptable salts” refers to the relatively non-toxic mineral and organic acid-addition salts, and the base-addition salts, of the compounds of the present invention. These salts may be prepared in situ during the final isolation and purification of the compounds. In particular, the acid-addition salts may be prepared by separately reacting the purified compound in its purified form with an organic or mineral acid and isolating the salt thus formed. Among the examples of acid-addition salts are the hydrobromide, hydrochloride, sulfate, bisulfate, phosphate, nitrate, acetate, oxalate, valerate, oleate, palmitate, stearate, laurate, borate, benzoate, lactate, phosphate, tosylate, citrate, maleate, fumarate, succinate, tartrate, naphthylate, mesylate, glucoheptonate, lactobionate, sulfamates, malonates, salicylates, propionates, methylenebis-b-hydroxynaphthoates, gentisic acid, isethionates, di-p-toluoyl-tartrates, methanesulfonates, ethanesulfonates, benzenesulfonates, p-toluene-sulfonates, cyclohexyl sulfamates and quinates-laurylsulfonate, and analogues. (See for example S. M. Berge et al. “Pharmaceutical Salts” J. Pharm. Sci, 66: pp. 1-19 (1977) which is incorporated herein by reference). The acid-addition salts may also be prepared by separately reacting the purified compound in its acid form with an organic or mineral base and isolating the salt thus formed. The acid-addition salts include amine salts and metal salts. The suitable metal salts include the sodium, potassium, calcium, barium, zinc, magnesium and aluminium salts. The sodium and potassium salts are preferred. The suitable mineral base-addition salts are prepared from metallic bases including sodium hydride, sodium hydroxide, potassium hydroxide, calcium hydroxide, aluminium hydroxide, lithium hydroxide, magnesium hydroxide and zinc hydroxide. The suitable amine base-addition salts are prepared from amines whose basicity is sufficient to form a stable salt, and preferably include amines that are often used in medicinal chemistry on account of their low toxicity and their acceptability for medical use: ammonia, ethylenediamine, N-methylglucamine, lysine, arginine, ornithine, choline, N,N′-dibenzylethylenediamine, chloroprocaine, diethanolamine, procaine, N-benzyl-phenethylamine, diethylamine, piperazine, tris(hydroxymethyl)aminomethane, tetramethylammonium hydroxide, triethylamine, dibenzylamine, ephenamine, dehydroabietylamine, N-ethylpiperidine, benzylamine, tetramethylammonium, tetraethylammonium, methylamine, dimethylamine, trimethylamine, ethylamine, basic amino acids, for example lysine and arginine, and dicyclohexylamine, and analogues.
The invention also relates to the tautomeric forms, enantiomers, diastereoisomers, epimers and organic or mineral salts of the compounds of the general formula (1).
The compounds of the invention of the formula (1) as defined above containing a sufficiently acidic function or a sufficiently basic function, or both, may include the corresponding pharmaceutically acceptable salts of an organic or mineral acid or of an organic or mineral base.
The compounds of the general formula (1) may be prepared by application or adaptation of any method known per se and/or within the capacity of a person skilled in the art, especially those described by Larock in Comprehensive Organic Transformations, VCH Pub., 1989, or by application or adaptation of the processes described in the procedures that follow.
The present invention thus also relates to the process for the preparation of the compounds of the formula (1) described above, comprising the step consisting in reacting a compound of the formula (A):




in which A, R1, R2, R′2′, n, n′, B, D and R3 are defined as in formula (1), with a compound of the formula (B) or (B′), according to the nature of the desired compound of the formula (1):

R4-Hal  (B)

R5-N═C═O  (B′)

in which R4 is defined as in formula (1) and Hal represents a halogen atom, preferably chlorine. Preferentially, this reaction is performed in a suitable solvent, for example acetonitrile, at a temperature of between 0° C. and the boiling point of the solvent, and preferably at room temperature, for a time necessary to obtain a satisfactory degree of progress of the reaction, generally for 1 hour to 2 days.

Preferably, the product of the formula (B) is used if, in formula (1), R4 represents




If R4 represents





a product of the formula (B′) is used.

Generally, the above reaction is performed using the ester (R1 other than H). If the acid is desired (R1=H), the reaction then also includes the step consisting in hydrolysing the ester to the acid.
This reaction is preferably performed in basic medium, especially in the presence of sodium hydrogen carbonate, potassium carbonate or an organic base, such as triethylamine or diisopropylethylamine, or alternatively sodium hydroxide or potassium hydroxide, or any other suitable base, in a suitable solvent, for example acetonitrile, at a temperature of between 0° C. and the boiling point of the solvent, preferably at room temperature, for a time required to obtain a satisfactory degree of progress of the reaction, generally for 1 hour to 2 days.
Preferably, the compound of the formula (B) corresponds to the following formulae:




in which R5 is defined as in formula (1) and Hal is defined as above.

If, in formula (1), R3 is other than H, the process for the preparation of the corresponding compounds also includes the step of preparing the compounds of the formula (A) in which R3 is other than H by reductive amination of the corresponding compounds of the formula (A) in which R3=H. This reaction may be performed by application or adaptation of any reductive amination method known per se. The process may especially be performed by means of a compound of aldehyde type corresponding to the desired compound of the formula (1), in the presence of sodium triacetoxyborohydride in a suitable solvent, such as dichloroethane, at a temperature of between 0° C. and the boiling point of the solvent, preferably at room temperature, for a time that is necessary to obtain a satisfactory degree of progress of the reaction, generally for 1 hour to 24 hours.
More specifically, the compounds of the general formula (1) as described above may be prepared according to the following representative methods (1), (2), (2a), (3) and (4).
In the following reaction schemes, A, R1, R2, R′2′, n, n′, B, D, R4 and R5 are defined as in formula (1) and Hal and Hal′ represent a halogen atom, such as Cl or Br.
The following schemes are given for representative purposes, and solely for the purpose of facilitating the representation. They have been represented for compounds containing given B, D and E. Needless to say, depending on the nature of the compounds of the formula (1) to be obtained, the methodologies presented may be adapted by a person skilled in the art by selecting the appropriate starting materials, in which the nature of the substituents B, D and E may be modified, especially as a function of the nature and length of the desired chain.
General Method 1:




Production of the Sulfonyl Derivatives





Production of the Acyl and Aminocarbonyl Derivatives





The synthesis of compound A1 may be performed via the action of a halide, such as phenyl bromide Y1 substituted onto a compound containing a triple bond Z1, in a solvent, such as triethylamine, in the presence of palladium chloride and triphenylphosphine. The triple bond of this intermediate is then reduced by hydrogenation in the presence of a catalyst, such as palladium-on-charcoal in a suitable solvent, such as methanol, dioxane or THF, at a temperature of between 25 and 90° C.
Compound B1 is then halogenated, for example via the action of PHal3, such as PBr3 in a suitable solvent, such as toluene, to give compound C1. The phosphonium halide (compound D1) is then obtained via the action of triphenylphosphine in a suitable solvent, such as acetonitrile. Compound E1 may be obtained via the action of a nitrobenzaldehyde X1 on compound D1 in water, at a temperature of between 50 and 100° C., in the presence of K2CO3. Compound F1 is then obtained by simultaneous hydrogenation of the double bond and of the nitro group in the presence of a catalyst, such as palladium-on-charcoal at a pressure of between 5 and 20 bar.
The sulfonyl derivatives G1 may be obtained via the action of a suitably selected sulfonyl halide, on compound F1, in the presence of a mineral base, for example sodium hydrogen carbonate, or an organic base, such as triethylamine or pyridine, in a solvent, such as acetonitrile, at a temperature of between 0° C. and the boiling point of the chosen solvent, the reaction time possibly ranging from 1 to 24 hours.
The ester, whether or not it is isolated, will be treated with, for example, aqueous sodium hydroxide solution to give the corresponding acid, in a temperature range of from 0° C. to 80° C. and preferably in a temperature range of from 0° C. to 50° C., the reaction time possibly ranging from 1 hour to 24 hours. A cosolvent, such as THF can be used to do this.
The derivatives of acyl type H1 may be obtained via a method similar to that described for the production of the derivatives of sulfonyl type. To this end, a suitable acyl halide will be reacted with compound F1.
Similarly, the ester obtained may or may not be isolated to saponify it via a method similar to that described above.
The compounds of aminocarbonyl type I1 may be obtained via the action of an isocyanate, for example, on compound F1. The reaction may be performed in a solvent chosen so as not to interfere with the reaction: dichloromethane, acetonitrile or toluene may especially be used, at a temperature of between 0° C. and the boiling point of the selected solvent, the reaction time possibly ranging from 1 to 24 hours.
The ester will be saponified in situ or after isolation, to give the acid. To this end, it is possible to use an aqueous sodium hydroxide solution in a temperature range of from 0° C. to 80° C., preferably hydroxide in a temperature range of from 0° C. to 50° C., the reaction time possibly ranging from 1 hour to 24 hours.
General Method 2:




Production of the Sulfonyl Derivatives





Production of the Acyl and Aminocarbonyl Derivatives





The synthesis of compound A2 may be performed starting with the corresponding compound Z2 via the action of a halogenating agent, preferably a brominating agent, for instance N-bromosuccinimide, in a suitable solvent, such as carbon tetrachloride, in the presence of a catalyst, for example benzoyl peroxide.
The corresponding phosphonium halide may be obtained by reacting the halogenated compound A2 with triphenylphosphine in refluxing acetonitrile.
Compound C2 may be obtained by reacting the phosphonium halide obtained via method 2 (compound 82) with a benzaldehyde substituted by a nitro group Y2 so as to obtain the desired intermediate, in a suitable solvent, such as THF or acetonitrile, in the presence of a strong base, for example sodium amide. Finally, the double bond and the nitro group may be reduced in a single step via catalytic hydrogenation in a suitable solvent, such as THF, methanol or a mixture thereof, in the presence, for example, of palladium-on-charcoal, to give compound D2.
The sulfonyl, acyl and aminocarbonyl derivatives may be obtained in the same manner as that indicated for method 1.
General Method 3:




Production of Sulfonyl Derivatives





Production of Acyl and Aminocarbonyl Derivatives





Compound C3 may be obtained by reacting the phosphonium halide obtained via method 2 (compound B2) with, for example, a corresponding phenylacetaldehyde substituted by a nitro group Z3 so as to obtain the desired intermediate C3, in a suitable solvent, such as an ether, such as dioxane or tetrahydrofuran, in the presence of a strong base for, for example sodium amide. Finally, the double bond and the nitro group may be reduced in a single step via catalytic hydrogenation in a suitable solvent of alcohol type, for example ethanol or methanol, in the presence of palladium-on-charcoal, at a pressure of between 1 and 20 bar, to give compound D3.
The sulfonyl, acyl and aminocarbonyl derivatives may be obtained in the same manner as that indicated for method 1.
General Method 4:




Production of the Sulfonyl Derivatives





Production of the Acyl and Aminocarbonyl Derivatives





Compound A4 may be obtained by reacting a compound of phenoxyalkyl halide (for example bromide) type bearing a nitro group, Y4, with a phenol bearing an acid function Z4 of the benzoic, acetic, propanoic, etc. type. The nitro group of the compound of the formula A4 may then be reduced via catalytic hydrogenation in the presence of a metal, for example palladium-on-charcoal, at a temperature of between room temperature and 80° C., in a solvent, such as an alcohol, for example methanol or ethanol, or an ether, such as tetrahydrofuran or dioxane, at a pressure of between 1 and 5 bar.
The compound of the general formula C4 will be obtained by reacting a suitably substituted sulfonyl halide with the compound of the general formula B4 in a suitable solvent, for example and in a non-limiting manner, DMF or acetonitrile at a temperature of between 20 and 80° C.
The sulfonyl, acyl and aminocarbonyl derivatives may be obtained as in method 1 or 2.
General Method 1, 2, 3, 4:




Production of the Sulfonyl Derivatives





Production of the Acyl and Aminocarbonyl Derivatives





The reductive amination reaction may be performed by application or adaptation of any reductive amination method known per se. The process may especially be performed using a compound of aldehyde type corresponding to the desired compound of the formula (1), in the presence of sodium triacetoxyborohydride in a suitable solvent, such as dichloroethane, at a temperature of between 0° C. and the boiling point of the solvent, preferably at room temperature, for a time required to obtain a satisfactory degree of progress of the reaction, generally from 1 hour to 24 hours.
The sulfonyl, acyl and aminocarbonyl derivatives may be obtained as in method 1.
The compounds of the formula (1) in which R1=H may be obtained from the corresponding compounds G1, H1, I1, E2, F2, G2, E3, F3, G3, C4, D4, E4, E′2, E′3, C′4, G′1, F′2, F′3, D′4, H′1, G′2, G′3, E′4 and I′1 in which R1 is other than H, via hydrolysis according to methods that are known per se.
Optionally, the said process may also include the step consisting in isolating the product obtained.
In the reactions described hereinbelow, it may be necessary to protect reactive functional groups, for example the hydroxyl, amino, imino, thio or carboxyl groups, if they are desired in the final product, to avoid their unwanted participation in the reactions. The conventional protecting groups can be used in accordance with the standard practice; for examples, see T. W. Green and P. G. M. Wuts in Protective Groups in Organic Chemistry, John Wiley and Sons, 1991; J. F. W. McOmie in Protective Groups in Organic Chemistry, Plenum Press, 1973.
The compound thus prepared may be recovered from the reaction mixture via the conventional means. For example, the compounds may be recovered by distilling the solvent from the reaction mixture or, if necessary, after distilling off the solvent from the mixture of the solution, pouring the remainder into water, followed by extraction with a water-immiscible organic solvent, and distilling the solvent from the extract. In addition, the product may also be purified, if so desired, by various techniques, such as recrystallisation, reprecipitation or various chromatographic techniques, especially column chromatography or preparative thin-layer chromatography.
It will be appreciated that the compounds that are useful according to the present invention may contain asymmetric centres. These asymmetric centres may be, independently, of R or S configuration. It will be apparent to a person skilled in the art that certain compounds that are useful according to the invention may also exhibit geometrical isomerism. It should be understood that the present invention includes individual geometrical isomers and stereoisomers, and mixtures thereof, including racemic mixtures, of compounds of the formula (1) above. Isomers of this type may be separated from their mixtures by application or adaptation of known processes, for example chromatography techniques or recrystallisation techniques, or they are prepared separately from suitable isomers of their intermediates.
For the purposes of the present text, it is understood that the tautomeric forms are included in the citation of a given group, for example thio/mercapto or oxo/hydroxyl.
The acid-addition salts are formed with the compounds that are useful according to the invention in which a basic function, such as an amino, alkylamino or dialkylamino group is present. The pharmaceutically acceptable, i.e. non-toxic, acid-addition salts are preferred. The selected salts are optimally chosen so as to be compatible with the usual pharmaceutical vehicles and suitable for oral or parenteral administration. The acid-addition salts of the compounds that are useful according to the present invention may be prepared by reacting the free base with the appropriate acid, by application or adaptation of known processes. For example, the acid-addition salts of the compounds that are useful according to the present invention may be prepared either by dissolving the free base in water or in a basified aqueous solution or suitable solvents containing the appropriate acid, and isolating the solvent by evaporating the solution, or by reacting the free base and the acid in an organic solvent, in which case the salt separates out directly or may be obtained by concentrating the solution. Among the acids that are suitable for use in the preparation of these salts are hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid, various organic carboxylic and sulfonic acids, such as acetic acid, citric acid, propionic acid, succinic acid, benzoic acid, tartaric acid, fumaric acid, mandelic acid, ascorbic acid, malic acid, methanesulfonic acid, toluenesulfonic acid, fatty acids, adipate, alginate, ascorbate, aspartate, benzenesulfonate, benzoate, cyclopentanepropionate, digluconate, dodecyl sulfate, bisulfate, butyrate, lactate, laurate, lauryl sulfate, malate, hydriodide, 2-hydroxyethanesulfonate, glycerophosphate, picrate, pivalate, pamoate, pectinate, persulfate, 3-phenylpropionate, thiocyanate, 2-naphthalenesulfonate, undecanoate, nicotinate, hemisulfate, heptonate, hexanoate, camphorate, camphorsulfonate and the like.
The acid-addition salts of the compounds that are useful according to the present invention may be regenerated from the salts by application or adaptation of known processes. For example, the parent compounds that are useful according to the invention may be regenerated from their acid-addition salts by treatment with an alkali, for example aqueous sodium bicarbonate solution or aqueous ammonia solution.
The compounds that are useful according to the present invention may be regenerated from their base-addition salts by application or adaptation of known processes. For example, the parent compounds that are useful according to the invention may be regenerated from their base-addition salts by treatment with an acid, for example hydrochloric acid.
The base-addition salts may be formed if the compound that is useful according to the invention contains a carboxyl group, or a sufficiently acidic bioisostere. The bases that can be used to prepare the base-addition salts preferably include those that produce, if they are combined with a free acid, pharmaceutically acceptable salts, i.e. salts whose cations are not toxic to the patient in the pharmaceutical doses of the salts, such that the beneficial inhibitory effects intrinsic to the free base are not negated by the side effects attributable to the cations. The pharmaceutically acceptable salts, including those derived from alkaline-earth metal salts, within the scope of the present invention include those derived from the following bases: sodium hydride, sodium hydroxide, potassium hydroxide, calcium hydroxide, aluminium hydroxide, lithium hydroxide, magnesium hydroxide, zinc hydroxide, ammonia, ethylenediamine, N-methylglucamine, lysine, arginine, ornithine, choline, N,N′-dibenzylethylenediamine, chloroprocaine, diethanolamine, procaine, N-benzylphenethylamine, diethylamine, piperazine, tris(hydroxymethyl)aminomethane, tetramethylammonium hydroxide and the like.
The compounds that are useful according to the present invention may be readily prepared, or formed during the process of the invention, in the form of solvates (for example hydrates). The hydrates of the compounds that are useful according to the present invention may be readily prepared by recrystallisation of an aqueous/organic solvent mixture, using organic solvents, such as dioxane, tetrahydrofuran or methanol.
The basic products or the reagents used are commercially available and/or may be prepared by application or adaptation of known processes, for example processes as described in the Reference Examples or obvious chemical equivalents thereof.
According to the present invention, the compounds of the formula (1) show hypoglycaemiant activity. They can reduce hyperglycaemia and more particularly the hyperglycaemia of non-insulin-dependent diabetes.
Insulin resistance is characterised by a reduction in the action of insulin (cf. Presse Médicale, 1997, 26 (No. 14), 671-677) and is involved in a large number of pathological conditions, such as diabetes and more particularly non-insulin-dependent diabetes (type II diabetes or NIDDM), dyslipidaemia, obesity and also certain microvascular and macrovascular complications, for instance arterial hypertension, atherosclerosis, inflammatory processes, macroangiopathy, microangiopathy, retinopathy and neuropathy.
In this respect, reference may be made, for example, to Diabetes, Vol. 37, 1988, 1595-1607; Journal of Diabetes And Its Complications, 1998, 12, 110-119 or Horm. Res., 1992, 38, 28-32.
The compounds of the invention especially show anti-hyperglycaemic activity.
The compounds of the formula (1) are thus useful in the treatment of pathologies associated with hyperglycaemia.
The present invention also relates to pharmaceutical compositions comprising a compound according to the invention with a pharmaceutically acceptable excipient.
Preferably, the said composition comprises an effective amount of the compound according to the invention.
The present invention also relates to the use of compounds of the general formula (1) for the preparation of pharmaceutical compositions for the prevention and/or treatment of pathologies associated with hyperglycaemia, more particularly diabetes.
Preferably, the said composition is administered to a patient in need thereof.
The pharmaceutical compositions according to the invention may be presented in forms intended for parenteral, oral, rectal, permucous or percutaneous administration.
They will thus be presented in the form of injectable solutions or suspensions or multi-dose bottles, in the form of plain or coated tablets, sugar-coated tablets, wafer capsules, gel capsules, pills, sachets, powders, suppositories or rectal capsules, solutions or suspensions, for percutaneous use in a polar solvent, or for permucous use.
The excipients that are suitable for such administrations are cellulose or microcrystalline cellulose derivatives, alkaline-earth metal carbonates, magnesium phosphate, starches, modified starches and lactose for solid forms.
For rectal use, cocoa butter or polyethylene glycol stearates are the preferred excipients.
For parenteral use, water, aqueous solutions, physiological saline and isotonic solutions are the vehicles most appropriately used.
The dosage may vary within wide ranges (0.5 mg to 1000 mg) depending on the therapeutic indication and the route of administration, and also on the age and weight of the patient.
The examples that follow illustrate the invention without, however, limiting it. The starting materials used are known products or products prepared according to known procedures.
The percentages are expressed on a weight basis, unless otherwise mentioned.
The compounds were characterised especially via the following analytical techniques:
The NMR spectra were acquired using a Brüker Advanced DPX200 MHz NMR spectrometer.
The masses were determined by HPLC coupled to an Agilent Series 1100 mass detector; the masses obtained were found in accordance with the theoretical masses.
The melting points (m.p.) were measured on a Leica VMHB Köfler block. The masses of the products obtained were in accordance with the theoretical values.


EXAMPLE 1
Methyl 2-bromomethylbenzoate
50 g of methyl 2-methylbenzoate (0.33 M), 60.4 g of N-bromosuccinimide (0.340 M) and 4 g of benzoyl peroxide are added to a 2000 ml reactor containing 1500 ml of carbon tetrachloride. The reaction mixture is refluxed for 2 hours. After cooling to room temperature, the reaction medium is concentrated under vacuum. The oil obtained is purified by chromatography on silica (eluent: CH2Cl2). 74.5 g of a colourless oil are obtained (98% yield).
TLC: diisopropyl ether/petroleum ether (50/50).
NMR (δ in ppm, DMSO, 200 MHz): 4.12 (s, 3H); 5.27 (s, 2H); 7.39 (d, 3H); 7.70 (d, 1H).
IR (cm−1): 1720, 1577, 1269, 1294.
EXAMPLE 2
2-Nitrophenylacetaldehyde
45 g of 2-nitrophenylpyruvic acid (2.15 M), 20.6 g of morpholine (2.37 M) and 1 g of para-toluenesulfonic acid are added to 270 ml of toluene in a 1000 ml reactor equipped with Dean-Stark apparatus. The reaction medium is refluxed until all of the water formed during the reaction has been removed. At 20° C., 12 ml of 3 M HCl are then added and stirring is continued for one hour. The organic phase is then washed, dried over Na2SO4 and then concentrated under vacuum. The red oil obtained is purified by chromatography on silica (eluent: 80/20 CH2Cl2/heptane). 29.7 g of a red oil are obtained (84% yield).
TLC: dichloromethane
NMR (δ in ppm, CDCl3, 200 MHz): 4.06 (s, 2H), 7.44 (dd, 1H), 7.68 (dd, 1H), 7.7 (d, 1H), 8.25 (d, 1H), 9.78 (t, 1H).
IR (cm−1): 1726; 1526; 1348.
EXAMPLE 3
2-Methoxycarbonylbenzyltriphenylphosphonium bromide
74.2 g of triphenylphosphine (0.28 M) in 200 ml of acetonitrile are added to a solution of 74.5 g of methyl 2-bromomethylbenzoate (0.32 M) in 170 ml of acetonitrile in a 2000 ml reactor. The reaction mixture is refluxed with stirring for one hour and then cooled. 1000 ml of diethyl ether are then added slowly. Stirring is continued for 2 hours. A white precipitate forms. The solid is filtered off and washed with acetone. After drying, 112.6 g of a white powder are obtained (81% yield).
m.p. (Köfler): 258° C.
NMR (δ in ppm, CDCl3, 200 MHz): 3.54 (s, 3H); 5.73 (d, 2H); 7.49 (d, 1H); 7.64 (m, 2H); 7.67 (m, 3H); 7.73 (m, 2H); 7.84 (m, 5H); 7.97 (m, 1H); 8.01 (m, 5H)
IR (cm−1): 1697; 1431; 1267; 1111; 1075.
EXAMPLE 4
Methyl 2-[3-(2-nitrophenyl)-1-propenyl]benzoate
67.6 g of the phosphonium salt obtained in Example 3 (0.14 M) and then 5.7 g of sodium amide (0.146 M) are added to 120 ml of tetrahydrofuran in a 500 ml reactor under an inert atmosphere (N2). The reaction medium is then stirred at room temperature for one hour. Next, 23.8 g of nitrophenylacetaldehyde (0.145 M) as a solution in 48 ml of tetrahydrofuran are added. The reaction medium is then refluxed for 5 minutes.
50 ml of 3M HCl are added and the mixture is extracted with ethyl acetate. The phases are separated by settling and the organic phase is dried over Na2SO4. The resulting solution is concentrated under vacuum. A red oil is obtained, which is purified by chromatography on silica (eluent: 95/5 CH2Cl2/acetone). 32.9 g of a red oil are obtained (80% yield).
TLC: dichloromethane.
NMR (δ in ppm, CDCl3, 200 MHz): 3.81 (s, 3H), 4.05 (dd, 2H), 6.99 (d, 1H), 7.19 (d, 1H), 7.50 (m, 6H), 7.90 (m, 2H),
IR (cm−1): 1720; 1608; 1526; 1570.
EXAMPLE 5
Methyl 2-[3-(2-aminophenyl)propyl]benzoate
31 g of methyl 2-[3-(2-nitrophenyl)-1-propenyl]benzoate obtained in Example 4 (0.1 M) are added to 255 ml of methanol and 3.1 g of wet 10% palladium-on-charcoal in a 1 litre stainless-steel reactor. The solution obtained is then stirred for 30 minutes at 20° C. under a hydrogen pressure of 10 bar. 200 ml of tetrahydrofuran are then added and the mixture is filtered through Celite. After evaporation, 27.3 g of a red oil that crystallises are obtained (yield: 98%).
m.p. (Köfler): 48-50° C.
TLC: dichloromethane.
NMR (δ in ppm, CDCl3, 200 MHz): 1.93 (m, 2H), 2.61 (t, 2H), 3.07 (t, 2H), 3.70 (multiplet, 2H), 3.95 (s, 3H), 6.74 (q, 2H), 7.34 (m, 4H), 7.50 (m, 1H), 7.92 (d, 1H).
IR (cm−1): 1710, 1452, 1432, 1254.
EXAMPLE 6
Methyl 2-[3-{2-[(4-methylphenyl)sulfonylamino]phenyl}propyl]benzoate
1 g of methyl 2-[3-(2-aminophenyl)propyl]benzoate obtained in Example 5 (3.7 mM), 0.71 g of 4-methylphenylsulfonyl chloride (3.7 mM) and 34 mg of NaHCO3 (4.1 mM) are added to 15 ml of acetonitrile in a 50 ml reactor. The reaction medium is stirred at 20° C. for 20 hours. 5 ml of 1M HCl are then added and the mixture is extracted with ethyl acetate. The organic phase is separated out after settling of the phases, washed and then dried over Na2SO4. After evaporation under vacuum, an oil is obtained, which is precipitated from ethyl ether. The solid is filtered off and washed with ether. 0.42 g of a grey-white solid is obtained (yield: 27%).
m.p. (Köfler): 98-100° C.
NMR (δ in ppm, CDCl3, 200 MHz): 2.21 (s, 1H); 2.42 (t, 4H); 2.69 (m, 2H); 3.72 (s, 3H); 6.84 (m; 2H); 7.20 (m, 1H); 7.24 (m, 2H); 7.44 (m, 5H); 7.69 (m, 2H); 9.43 (s, 1H).
IR (cm−1): 3282; 1718; 1254; 1160.
EXAMPLE 7
2-[3-{2-[(4-Methylphenyl)sulfonylamino]phenyl}propyl]benzoic acid
Methyl 2-[3-{2-[(4-methylphenyl)sulfonylamino]phenyl}propyl]benzoate (0.84 mM) obtained in Example 6 and 4.5 ml of aqueous 1M NaOH (4.5 mM) are added to 3 ml of acetonitrile in a 50 ml reactor. The reaction medium is then heated at 50° C. for 2 hours with stirring. The resulting mixture is cooled to room temperature, 2.5 ml of 3M HCl are then added and the mixture is stirred for 20 hours. The solid that precipitates is then filtered off and washed with water. 0.33 g of a pink solid is obtained (100% yield).
m.p. (Köfler): 142-144° C.
NMR (δ in ppm, CDCl3, 200 MHz): 2.4 (s, 3H); 2.6 (m, 4H); 2.8 (d, 2H); 3.7 (lump, 1H); 1.5 (multiplet, 12H); 9.6 (s, 1H).
IR (cm−1): 3280; 1690; 1670; 1490; 1406; 1330; 1162.
By way of example, the following compounds are prepared according to the procedures described in Example 7:












R5
M
No.
































452.5
1


 






429.9
2


 


H3C—
333.4
3


 






425.5
4


 






440.4
5


 






409.5
6


 






463.4
7


 






445.5
8


 






409.5
9


 






455.53
10


 






423.54
11


 






413.47
12


 






431.46
13


 






463.48
14


 






413.47
15


 






471.58
16


 






437.52
17


 






347.44
18


 






375.49
19


 






467.59
20


 






488.61
21


 






445.54
22


 






473.57
23


 






395.48
24


 






464.37
25


 






437.56
26


 






451.59
27


 






421.52
28


 






455.53
29


 






401.51
30


 






361.46
31


 






541.67
32


 






479.48
33


 






467.59
34


 






427.50
35


 






479.48
36


 






431.46
37


 






451.59
38


 






425.51
39


 






465.62
40


 






531.48
41


 






437.56
42


 






437.56
43


 






413.47
44


 






409.51
45


 






541.67
46


 






465.62
47


 






420.49
48


 






423.54
49


 






463.48
50
























452.53
51


 






429.93
52


 


H3C—
333.41
53


 






425.51
54


 






440.48
55


 






409.51
56


 






463.48
57


 






445.54
58


 






409.51
59


 






455.53
60


 






423.54
61


 






413.47
62


 






431.46
63


 






463.48
64


 






413.47
65


 






471.58
66


 






437.52
67


 






347.44
68


 






375.49
69


 






467.59
70


 






488.61
71


 






445.54
72


 






473.57
73


 






395.48
74


 






464.37
75


 






437.56
76


 






451.59
77


 






421.52
78


 






455.53
79


 






401.51
80


 






361.46
81


 






541.67
82


 






479.48
83


 






467.59
84


 






427.50
85


 






431.46
86


 






451.59
87


 






425.51
88


 






465.62
89


 






531.48
90


 






437.56
91


 






437.56
92


 






413.47
93


 






409.51
94


 






541.67
95


 






465.62
96


 






420.49
97


 






423.54
98


 






463.48
99


 






469.60
100
























452.53
101


 






429.93
102


 






425.51
103


 






440.48
104


 






409.51
105


 






463.48
106


 






445.54
107


 






455.53
108


 






423.54
109


 






413.47
110


 






431.46
111


 






463.48
112


 






413.47
113


 






471.58
114


 






437.52
115


 






488.61
116


 






445.54
117


 






473.57
118


 






395.48
119


 






464.37
120


 






437.56
121


 






451.59
122


 






421.52
123


 






455.53
124


 






541.67
125


 






479.48
126


 






467.59
127


 






427.50
128


 






479.48
129


 






431.46
130


 






451.59
131


 






425.51
132


 






465.62
133


 






437.56
134


 






437.56
135


 






413.47
136


 






409.51
137


 






541.67
138


 






439.49
139


 






500.04
140









EXAMPLE 8
Methyl 2-(4-hydroxybut-1-ynyl)benzoate
50 ml (0.36 M) of methyl 2-bromobenzoate, 930 mg (3.56 mM) of triphenylphosphine and 316 mg (1.78 mM) of PdCl2 are added to 1200 ml of diethylamine in a 2000 ml reactor. After stirring at room temperature for 5 minutes, 27 ml (0.36 M) of 3-butyn-1-ol and 680 mg (3.56 mM) of CuI (1) are added. The reaction medium is then stirred at 20° C. for 120 hours, the solvent is then evaporated off and the residue obtained is then purified by chromatography on silica, using dichloromethane as eluent. After evaporation, 46.7 g of a brown oil are thus obtained (64% yield).
NMR (δ in ppm, DMSO, 200 MHz): 2.85 (t, 2H); 3.88 (q, 2H); 4.08 (s, 3H); 7.77 (multiplet, 3H); 8.04 (d, 1H).
EXAMPLE 9
Methyl 2-(4-hydroxybutyl)benzoate
46.6 g (0.023 M) of methyl 2-(4-hydroxybut-1-ynyl)benzoate and 5 g of wet 10% palladium-on-charcoal are added to 900 ml of methanol in a 2000 ml stainless-steel autoclave. The reaction medium is then stirred under hydrogen pressure (10 bar) at 70° C. for 16 hours.
The reaction medium is then filtered through Celite and concentrated under vacuum to give 46.5 g of a pale yellow oil (98% yield).
NMR (δ in ppm, DMSO, 200 MHz): 1.64 (multiplet, 4H); 3.1 (t, 2H); 3.55 (m, 2H); 3.98 (s, 3H); 7.49 (m, 2H); 7.64 (m, 1H); 7.90 (d, 1H).
EXAMPLE 10
Methyl 2-(4-bromobutyl)benzoate
46.5 g (0.22 M) of methyl 2-(4-hydroxybutyl)benzoate are added to 120 ml of toluene predried over molecular sieves, in a 1000 ml reactor. 7 ml (0.073 M) of PBr3 are then added and the reaction medium is stirred for 72 hours at room temperature.
The reaction medium is then added slowly to 800 ml of demineralised water.
The mixture is then extracted with ethyl acetate and the organic phase is separated out after settling of the phases, washed with demineralised water and then dried over sodium sulfate and finally concentrated under vacuum.
42.5 g of an oil are thus obtained, and are used as obtained, without further purification (71% yield).
NMR (δ in ppm, DMSO, 200 MHz): 1.59 (m, 2H); 1.78 (m, 2H); 2.86 (t, 2H); 3.49 (t, 2H); 3.79 (s, 3H); 7.31 (m, 2H); 7.46 (m, 1H); 7.75 (d, 1H).
EXAMPLE 11
Methyl 2-(4-bromobutyltriphenylphosphonium)benzoate
41 g (0.16 M) of triphenylphosphine and 42.4 g (0.16 M) of methyl 2-(4-bromobutyl)benzoate are added to 160 ml of acetonitrile predried over molecular sieves, in a 1000 ml reactor, and the mixture is then refluxed with stirring for 20 hours. The reaction medium is then concentrated under vacuum and the residue obtained is taken up in a mixture of 100 ml of dichloromethane and 700 ml of diisopropyl ether.
The crystalline solid is filtered off and washed and then dried under vacuum to give 76.1 g of a white solid (91% yield).
NMR (δ in ppm, DMSO, 200 MHz): 1.63 (m, 2H); 1.78 (m, 2H); 2.95 (t, 2H); 3.71 (m, 2H); 3.83 (s, 3H); 7.37 (m, 1H); 7.52 (m, 2H); 7.83 (multiplet, 16H).
EXAMPLE 12
Methyl 2-[5-(2-nitrophenyl)pent-4-enyl]benzoate
75 g (0.14 M) of methyl 2-(4-bromobutylphosphonium)benzoate obtained in Example 12, 7 g (0.17 M) of 2-nitrobenzaldehyde and 23.3 g (0.25 M) of K2CO3 are added to a mixture of 140 ml of dioxane and 4.5 ml of water in a 500 ml reactor, and the reaction medium is then maintained at 95° C. with stirring for 1 hour. The resulting mixture is filtered and the solution obtained is concentrated under vacuum. The residue obtained is then purified by chromatography on silica, using dichloromethane as eluent. 36.1 g of a thick oil are thus obtained (98% yield).
NMR (δ in ppm, DMSO, 200 MHz): 1.58 (m, 2H); 2.01 (m, 2H); 2.71 (t, 2H); 3.69 (s, 3H); 5.78 (m, 1H); 6.51 (m, 1H); 7.5 (multiplet, 8H).
EXAMPLE 13
Methyl 2-[5-(2-aminophenyl)pentyl]benzoate
36 g (0.11 M) of methyl 2-[5-(2-nitrophenyl)pentyl]benzoate and 4 g of palladium-on-charcoal are added to 400 ml of methanol in a 1000 ml stainless-steel autoclave. The reaction medium is then stirred under hydrogen pressure (10 bar) at 70° C. for 3 hours.
The reaction medium is then filtered through Celite and concentrated under vacuum.
The residue obtained is then purified by chromatography on silica, using dichloromethane as eluent. 28.2 g of an orange-coloured oil are thus obtained (86% yield).
NMR (δ in ppm, DMSO, 200 MHz): 1.59 (m, 2H); 1.73 (m, 4H); 2.61 (m, 2H); 3.07 (t, 2H); 4.01 (s, 3H); 4.96 (s, 2H); 6.67 (t, 1H); 6.82 (d, 1H); 7.07 (m, 3H); 7.5 (m, 2H); 7.97 (d, 1H).
EXAMPLE 14
2-{5-[2-(2,4,6-Trimethylphenylsulfonylamino)phenyl)pentyl}benzoic acid
19.8 g (0.066 M) of methyl 2-[5-(2-aminophenyl)pentyl]benzoate, 6.15 g (0.073 M) of sodium hydrogen carbonate and 14.6 g (0.066 M) of 2,4,6-trimethylbenzenesulfonyl chloride are added to 280 ml of acetonitrile in a 1000 ml reactor. The reaction medium is then stirred at 20° C. for 20 hours.
The intermediate ester is not isolated: 330 ml of aqueous 1N sodium hydroxide solution are added to the reaction medium and the mixture is stirred at 50° C. for 2 hours. The reaction medium is then washed with ethyl acetate and with diethyl ether in order to remove the impurities. The aqueous phase is then acidified with 3N hydrochloric acid, precipitation is observed, and stirring is continued for 16 hours. The precipitate is filtered off and washed thoroughly with water to give, after drying at 70° C. under vacuum, 21.1 g of a white solid (yield: 81%).
m.p. (Köfler): 119-121° C.
NMR (δ in ppm, DMSO, 200 MHz): 1.24 (m, 4H); 1.48 (m, 2H); 2.22 (s, 3H); 2.37 (m, 8H); 2.94 (t, 2H); 7.3 (multiplet, 10H); 9.48 (s, 1H); 12.87 (s, 1H).
By way of example, the following compounds are prepared according to the procedure described in Example 14:
















 









R5
MW
No.
















480.59
141


 






457.98
142


 


H3C—
361.46
143


 






453.56
144


 






468.53
145


 






437.56
146


 






491.53
147


 






473.60
148


 






437.56
149


 






483.59
150


 






451.59
151


 






441.53
152


 






459.52
153


 






491.53
154


 






441.53
155


 






465.57
156


 






375.49
157


 






495.64
158


 






516.66
159


 






473.60
160


 






423.54
161


 






492.43
162


 






465.62
163


 






479.64
164


 






483.59
165


 






507.53
166


 






429.56
167


 






474.58
168


 






507.53
169


 






495.64
170


 






459.52
171


 






453.56
172


 






493.67
173


 






465.62
174


 






465.62
175


 






437.56
176


 






569.72
177


 






493.67
178


 






451.59
179


 






491.53
180









EXAMPLE 15
2-{5-[2-(benzoylamino)phenyl]pentyl}benzoic acid
100 mg (0.34 mM) of 2-{5-[2-aminophenyl]pentyl}benzoic acid, 39.5 ml (0.34 mM) of benzoyl chloride and 47 mg (0.34 mM) of K2CO3 are added to 1.5 ml of acetonitrile predried over molecular sieves, in a 15 ml reactor, and the reaction medium is then stirred at 20° C. for 20 hours. 1 ml of methanol and 2 ml of aqueous 1N sodium hydroxide solution are then added and the mixture is maintained at 50° C. with stirring for 2 hours.
3 ml of 1N hydrochloric acid are added and the mixture is stirred at 20° C. for 20 hours. The precipitated solid is filtered off, washed and dried under vacuum to give 55 mg of a white solid.
(Yield: 54%)
NMR (δ in ppm, DMSO, 200 MHz): 1.5 (m, 2H); 1.75 (m, 4H); 2.85 (t, 2H); 3.05 (t, 2H); 7.7 (multiplet, 13H); 10.1 (s, 1H); 13 (s, 1H).
By way of example, the following compounds are prepared according to the procedure described in Example 15:
















 









R5
MW
No.
















443.59
181


 






383.45
182


 






397.48
183


 






435.96
184


 






421.93
185


 






456.37
186


 






456.37
187


 






369.42
188


 






405.47
189


 






415.54
190


 






367.49
191


 






417.51
192


 






401.51
193


 






367.49
194


 






401.51
195


 






401.51
196


 






423.46
197


 






427.55
198


 






409.57
199


 






415.54
200


 






456.37
201


 






437.54
202


 






431.54
203


 






355.44
204


 






393.53
205


 






353.47
206


 






379.50
207


 






353.47
208


 






341.41
209


 






429.56
210


 






339.44
211


 






419.50
212


 






355.44
213


 






431.54
214


 






381.52
215


 






381.52
216


 






407.56
217


 






367.49
218


 






439.52
219


 






423.4
220


 






473.4
221


 






421.9
222


 






417.5
223


 






387.4
224


 






381.5
225


 






421.9
226


 






405.4
227


 






437.5
228


 







229









EXAMPLE 16
4-Methoxycarbonylbenzyltriphenylphosphonium bromide
This compound is prepared via a method similar to that described in Example 3 for obtaining 2-methoxycarbonylbenzyltriphenylphosphonium. The desired compound is thus obtained in a yield of 77%.
NMR (δ in ppm, DMSO, 200 MHz): 3.84 (s, 3H); 5.42 (d, 2H); 7.2 (d, 2H); 0.8 (multiplet, 17H).
EXAMPLE 17
Methyl 4-[2-(3-nitrophenyl)vinyl]benzoate
71.2 g of 4-methoxycarbonylbenzyltriphenylphosphonium bromide and 23 g (0.15 M) of 3-nitrobenzaldehyde are added to 360 ml of acetonitrile in a 1000 ml reactor. 19 ml (0.15 M) of 1,5-diazobicyclo[4.3.0]non-5-ene (DBN) are then added and the reaction medium is then refluxed with stirring for 1 hour. The solvent is then evaporated off and the residue obtained is then purified by chromatography on silica, using dichloromethane as eluent. After evaporation, 41.6 g of a white solid are obtained (yield: 95%).
NMR (δ in ppm, DMSO, 200 MHz): 3.86 (s, 3H); 7.8 (multiplet, 10H).
EXAMPLE 18
Methyl 4-[2-(3-aminophenyl)ethyl]benzoate
28.8 g (0.14 M) of methyl 4-[2-(3-nitrophenyl)vinyl]benzoate obtained in Example 16 and 4 g of wet 10% palladium-on-charcoal are added to 400 ml of methanol and 100 ml of tetrahydrofuran in a 1000 ml autoclave. The reaction medium is then stirred for 30 hours at 90° C. under a hydrogen pressure of 30 bar.
After filtration through Celite, the reaction medium is concentrated under vacuum and then purified by chromatography on silica, using dichloromethane as eluent. After evaporating off the solvent under vacuum, 24 g of a pink solid are thus obtained (yield: 68%).
NMR (δ in ppm, DMSO, 200 MHz): 2.96 (m, 2H); 3.11 (m, 2H); 4.05 (s, 3H); 5.16 (s, 2H); 6.60 (m, 3H); 7.12 (t, 1H); 7.59 (d, 2H); 8.10 (d, 2H).
EXAMPLE 19
4-{2-[3-(4-Butylphenylsulfonylamino)phenyl)ethyl}benzoic acid
17.9 g (0.07 M) of methyl 4-{2-[3-(phenylsulfonylamino)phenyl]ethyl}benzoate and 13 g (0.15 M) of sodium hydrogen carbonate are added to 250 ml of acetonitrile in a 500 ml reactor. 16.3 g (0.07 M) of 4-butylphenylsulfonyl chloride are then added, and the reaction medium is then stirred at 20° C. for 72 hours.
350 ml of aqueous sodium hydroxide solution are then added and the reaction medium is maintained at 50° C. for 2 hours, then acidified with 3 N hydrochloric acid, and the precipitated solid is filtered off, washed with water and then dried under vacuum to give 28.8 g of a white solid (yield: 94%).
m.p. (Köfler): 164-166° C.
NMR (δ in ppm, DMSO, 200 MHz): 1 (s, 3H); 1.4 (t, 2H); 1.6 (t, 2H); 2.7 (m, 2H); 3 (m, 4H); 7.4 (multiplet, 12H); 10.30 (s, 1H).
By way of example, the following compounds are prepared according to the procedures described in Examples 18 and 19












R5
MW
No.
































415.90
230


 


H3C—
319.38
231


 






411.48
232


 






395.48
233


 






361.46
234


 






455.58
235


 






381.45
236


 






438.51
237


 






395.48
238


 






449.45
239


 






431.51
260


 






441.51
261


 






409.51
262


 






399.44
263


 






417.43
264


 






449.45
265


 






399.44
266


 






423.49
267


 






474.58
268


 






333.41
269


 






450.34
289


 






407.49
290


 






465.45
291


 






465.45
292


 






413.47
293


 






37.56
294


 






451.59
295


 






517.45
296


 






423.54
297


 






423.54
298


 






395.48
318


 






399.44
319


 






431.51
320


 






459.55
321


 






507.70
322


 






423.54
323


 






437.56
324


 






441.51
325


 






387.48
326


 






347.44
327


 






527.64
348


 






453.56
349


 






417.43
350


 






411.48
351


 






527.64
352


 






451.59
353


 






406.46
354


 






449.45
355
























415.90
240


 


H3C—
319.38
241


 






411.48
242


 






395.48
243


 






361.46
244


 






455.58
245


 






381.45
246


 






438.51
247


 






395.48
248


 






449.45
249


 






431.51
270


 






441.51
271


 






409.51
272


 






399.44
273


 






417.43
274


 






449.45
275


 






399.44
276


 






423.49
277


 






474.58
278


 






333.41
279


 






450.34
299


 






407.49
300


 






465.45
301


 






465.45
302


 






413.47
303


 






37.56
304


 






451.59
305


 






517.45
306


 






423.54
307


 






423.54



 






395.48
328


 






399.44
329


 






431.51
330


 






459.55
331


 






507.70
332


 






423.54
333


 






437.56
334


 






441.51
335


 






387.48
336


 






347.44
337


 






527.64
356


 






453.56
357


 






417.43
358


 






411.48
359


 






527.64
360


 






451.59
361


 






406.46
362


 






449.45
363
























415.90
250


 


H3C—
319.38
251


 






411.48
252


 






395.48
253


 






361.46
254


 






455.58
255


 






381.45
256


 






438.51
257


 






395.48
258


 






449.45
259


 






431.51
280


 






441.51
281


 






409.51
282


 






399.44
283


 






417.43
284


 






449.45
285


 






399.44
286


 






423.49
287


 






474.58
288


 






333.41


 






450.34
308


 






407.49
309


 






465.45
310


 






465.45
311


 






413.47
312


 






37.56
313


 






451.59
314


 






517.45
315


 






423.54
316


 






423.54
317


 






395.48
338


 






399.44
339


 






431.51
340


 






459.55
341


 






507.70
342


 






423.54
343


 






437.56
344


 






441.51
345


 






387.48
346


 






347.44
347


 






527.64
364


 






453.56
365


 






417.43
366


 






411.48
367


 






527.64
368


 






451.59
369


 






406.46
370


 






449.45
371
























415.90
372


 


H3C—
319.38
373


 






411.48
374


 






395.48
375


 






361.46
376


 






455.58
377


 






381.45
378


 






438.51
379


 






395.48
380


 






449.45
381


 






431.51
402


 






441.51
403


 






409.51
404


 






399.44
405


 






417.43
406


 






449.45
407


 






399.44
408


 






423.49
409


 






333.41
410


 






474.58
411


 






450.34
432


 






407.49
433


 






465.45
434


 






465.45
435


 






413.47
436


 






7.56
437


 






451.59
438


 






517.45
439


 






395.48
440


 






423.54
441


 






399.44
461


 






431.51
462


 






459.55
463


 






423.54
464


 






437.56
465


 






441.51
466


 






387.48
467


 






347.44
468


 






527.64
469


 






423.54
470


 






453.56
490


 






417.43
491


 






411.48
492


 






527.64
493


 






451.59
494


 






406.46
495


 






449.45
496


 






425.46
497


 






486.01
498


 






432.50
499


 






























415.90
382


 


H3C—
319.38
383


 






411.48
384


 






395.48
385


 






361.46
386


 






455.58
387


 






381.45
388


 






438.51
389


 






395.48
390


 






449.45
391


 






431.51
412


 






441.51
413


 






409.51
414


 






399.44
415


 






417.43
416


 






449.45
417


 






399.44
418


 






423.49
419


 






333.41
420


 






474.58
421


 






450.34
442


 






407.49
443


 






465.45
444


 






465.45
445


 






413.47
446


 






7.56
447


 






451.59
448


 






517.45
449


 






395.48
450


 






423.54



 






399.44
471


 






431.51
472


 






459.55
473


 






423.54
474


 






437.56
475


 






441.51
476


 






387.48
477


 






347.44
478


 






527.64
479


 






423.54


 






453.56
500


 






417.43
501


 






411.48
502


 






527.64
503


 






451.59
504


 






406.46
505


 






449.45
506


 






425.46
507


 






486.01
508


 






432.50
509


 







510
























415.90
392


 


H3C—
319.38
393


 






411.48
394


 






395.48
395


 






361.46
396


 






455.58
397


 






381.45
398


 






438.51
399


 






395.48
400


 






449.45
401


 






431.51
422


 






441.51
423


 






409.51
424


 






399.44
425


 






417.43
426


 






449.45
427


 






399.44
428


 






423.49
429


 






333.41
430


 






474.58
431


 






450.34
451


 






407.49
452


 






465.45
453


 






465.45
454


 






413.47
455


 






7.56
456


 






451.59
457


 






517.45
458


 






395.48
459


 






423.54
460


 






399.44
480


 






431.51
481


 






459.55
482


 






423.54
483


 






437.56
484


 






441.51
485


 






387.48
486


 






347.44
487


 






527.64
488


 






423.54
489


 






453.56
511


 






417.43
512


 






411.48
513


 






527.64
514


 






451.59
515


 






406.46
516


 






449.45
517


 






425.46
518


 






486.01
519


 






432.50
520


 







521
























415.90
522


 


H3C—
319.38
523


 






411.48
524


 






395.48
525


 






361.46
526


 






455.58
527


 






381.45
528


 






438.51
529


 






395.48
530


 






449.45
531


 






431.51
541


 






441.51
542


 






409.51
543


 






399.44
544


 






417.43
545


 






449.45
546


 






399.44
547


 






423.49
548


 






450.34
549


 






407.49
550


 






465.45
561


 






465.45
562


 






413.47
563


 






437.56
564


 






451.59
565


 






517.45
566


 






423.54
567


 






423.54
568


 






395.48
569


 






399.44
570


 






333.41
571


 






431.51
582


 






459.55
583


 






507.70
584


 






423.54
585


 






437.56
586


 






441.51
587


 






387.48
588


 






347.44
589


 






527.64
590


 






453.56
591


 






417.43
602


 






411.48
603


 






527.64
604


 






451.59
605


 






406.46
606


 






449.45
607


 






425.46
608


 






486.01
609


 






409.51
610


 






457.55
611


 
























415.90
532


 


H3C—
319.38
533


 






411.48
534


 






395.48
535


 






361.46
536


 






455.58
537


 






381.45
538


 






438.51
539


 






395.48
540


 






449.45


 






431.51
551


 






441.51
552


 






409.51
553


 






399.44
554


 






417.43
555


 






449.45
556


 






399.44
557


 






423.49
558


 






450.34
559


 






407.49
560


 






465.45
572


 






465.45
573


 






413.47
574


 






437.56
575


 






451.59
576


 






517.45
577


 






423.54
578


 






423.54
579


 






395.48
580


 






399.44
581


 






333.41


 






431.51
592


 






459.55
593


 






507.70
594


 






423.54
595


 






437.56
596


 






441.51
597


 






387.48
598


 






347.44
599


 






527.64
600


 






453.56
601


 






417.43
612


 






411.48
613


 






527.64
614


 






451.59
615


 






406.46
616


 






449.45
617


 






425.46
618


 






486.01
619


 






409.51
620


 






457.55
























415.90
621


 


H3C—
319.38
622


 






411.48
623


 






395.48
624


 






361.46
625


 






455.58
626


 






381.45
627


 






438.51
628


 






431.51
629


 






441.51
630


 






399.44
631


 






417.43
632


 






449.45
633


 






399.44
634


 






423.49
635


 






333.41
636


 






474.58
637


 






450.34
638


 






407.49
639


 






465.45
640


 






465.45
641


 






423.54
642


 






423.54
643


 






459.55
644


 






507.70
645


 






423.54
646


 






437.56
647


 






387.48
648


 






347.44
649


 






527.64
650


 






453.56
651


 






417.43
652


 






527.64
653


 






451.59
654


 






406.46
655


 






425.46
656


 






486.01
657


 






432.50
658


 






457.55
659


 






409.51
660









EXAMPLE 20
Methyl 4-[2-(2-butylaminophenyl)ethyl]benzoate
20 g (0.078 M) of 4-[2-(2-phenyl)ethyl]benzoic acid, 6.3 g (0.072 M) of butyraldehyde and 22.6 g (0.107 M) of sodium triacetoxyborohydride are added to 80 ml of 1,2-dichloroethane in a 500 ml reactor, and the mixture is then stirred at 20° C. for 20 hours.
Water is then added to the reaction medium and the resulting mixture is extracted with dichloromethane. The organic phase is separated out by settling of the phases, washed with water and then dried and evaporated under vacuum. The residue obtained is then purified by chromatography on silica, using a dichloromethane/heptane mixture (70/30) as eluent. After evaporation, 11 g of the desired compound are obtained in the form of an oil (yield: 45%).
NMR (δ in ppm, DMSO, 200 MHz): 1.1 (t, 3H); 1.6 (m, 4H); 2.8 (m, 2H); 3.0 (m, 2H); 3.1 (m, 2H); 4.1 (s, 3H); 5.1 (s, 1H); 7.5 (multiplet, 8H).
EXAMPLE 21
Compound 680
4-{2-[2-([3,5-Bis trifluoromethyl]phenylsulfonylbutylamino)phenyl]-ethyl}benzoic acid
120 mg (0.38 mM) of methyl 4-[2-(2-butylaminophenyl)ethyl]benzoate obtained in Example 20 and 50 mg (0.38 mM) of diisopropylethylamine are added to 4 ml of acetonitrile predried over molecular sieves, in a 15 ml reactor. 120 mg (0.96 mM) of 3,5-bis(trifluoro)benzenesulfonyl chloride are then added and the reaction medium is stirred at 20° C. for 20 hours.
1.9 ml of aqueous 1N sodium hydroxide solution are then added and the reaction medium is maintained at 50° C. for 2 hours. 1 ml of 3N hydrochloric acid are then added and, after stirring for 1 hour, the precipitate formed is filtered off. After drying under vacuum, 43 mg of solid are obtained (yield: 20%).
NMR (δ in ppm, DMSO, 200 MHz): 1.0 (t, 3H); 1.4 (m, 4H); 3.2 (m, 4H); 3.6 (m, 4H); 7.8 (multiplet, 11H).
By way of example, the following compounds are prepared according to the procedures described in Example 21:












R5
MW
No.
































472.01
661


 






467.59
662


 






437.56
663


 






451.59
664


 






505.56
665


 






487.62
666


 






497.62
667


 






465.62
668


 






455.55
669


 






473.54
670


 






479.60
671


 






530.69
672


 






506.45
673


 






463.60
674


 






521.56
675


 






521.56
676


 






469.58
677


 






493.67
678


 






507.70
679


 






573.56
680


 






479.64
681


 






479.64
682


 






451.59
683


 






455.55
684


 






487.62
685


 






515.65
686


 






479.64
687


 






493.67
688


 






497.62
689


 






443.59
690


 






583.75
691


 






509.67
692


 






473.54
693


 






467.59
694


 






507.70
695


 






462.57
696


 






505.56
697


 






465.62
698


 
























514.09
699


 






479.64
700


 






493.67
701


 






547.64
702


 






529.70
703


 






539.70
704


 






507.70
705


 






497.63
706


 






515.62
707


 






547.64
708


 






497.63
709


 






521.68
710


 






505.68
711


 






563.64
712


 






511.66
713


 






535.75
714


 






521.72
715


 






521.72
716


 






493.67
717


 






497.63
718


 






529.7
719


 






557.7
720


 






539.7
721


 






515.6
722


 






509.6
723


 






549.7
724


 






504.6
725


 






547.6
726


 







727









EXAMPLE 22
Methyl 4-[2-(4-nitrophenoxy)ethoxy]benzoate
73.7 g (0.3 M) of (4-nitrophenoxy)-1-bromoethyl [lacuna] and then 45.6 g (0.3 M) of methyl 4-hydroxybenzoate and 138.2 g (0.6 M) of K2CO3 are added to 300 ml of methyl isobutyl ketone in a 1000 ml reactor. The reaction medium is then refluxed with stirring 20 hours.
The reaction medium is then taken up in water and extracted with ethyl acetate. The organic phase is separated out by settling of the phases and then washed with aqueous 1N sodium hydroxide solution, and then with saturated aqueous sodium chloride solution.
After evaporation of the organic phase under vacuum, the residue obtained is purified by chromatography on silica, with dichloromethane as eluent.
After concentrating, 68.5 g of a beige-coloured solid are obtained (yield: 72%).
NMR (δ in ppm, DMSO, 200 MHz): 3.97 (s, 3H); 4.65 (m, 4H); 7.24 (d, 2H); 7.39 (d, 2H); 8.10 (d, 2H); 8.35 (d, 2H).
EXAMPLE 23
Methyl 4-[2-(4-aminophenoxy)ethoxy]benzoate
68.4 g (0.22 M) of methyl 4-[2-(4-nitrophenoxy)ethoxy]benzoate and 1.3 g of palladium-on-charcoal are added to a mixture of 800 ml of methanol and 200 ml of tetrahydrofuran in a 2000 ml reactor, and the mixture is then maintained under ambient pressure of hydrogen at 60° C. with vigorous stirring for 6 hours.
After filtration through Celite, the solution obtained is evaporated under vacuum and the residue is taken up while hot in 100 ml of THF, and a solid crystallises. The solid is isolated and purified by chromatography on silica, with dichloromethane as eluent. After concentrating, 19.6 g of a beige-coloured solid are obtained (yield: 77%).
NMR (δ in ppm, DMSO, 200 MHz): 3.9 (s, 3H); 4.3 (m, 4H); 7 (multiplet, 6H); 8 (m, 2H).
EXAMPLE 24
4-{2-[4-(4-Fluorophenylsulfonylamino)phenoxy)ethoxy}benzoic acid
100 mg (0.35 M) of methyl 4-[2-(4-aminophenoxy)ethoxy]benzoate, 0.029 g (0.35 mM) of sodium hydrogen carbonate and 66.3 mg (0.35 mM) of 4-fluorobenzenesulfonyl chloride are added to 1 ml of acetonitrile predried over molecular sieves, in a 15 ml reactor.
The reaction medium is then stirred at 20° C. for 16 hours. The intermediate ester is not isolated: 1.6 ml of aqueous 1N sodium hydroxide solution are added and the mixture is maintained at 50° C. with stirring for 1 hour. After cooling to 20° C., the reaction medium is acidified with 2 ml of 1N hydrochloric acid and, after stirring at 20° C. for 30 minutes, the precipitate formed is filtered off. The solid obtained is then washed with water, and then dried under vacuum to give 80 mg of 4-{2-[4-(4-fluorophenylamino)phenoxy)ethoxy}benzoic acid (51% yield).
NMR (δ in ppm, DMSO, 200 MHz): 4.1 (m, 4H); 6.8 (m, 6H); 7.2 (m, 2H); 7.55 (m, 2H); 7.7 (m, 2H); 9.75 (s, 1H).
By way of example, the following compounds are prepared according to the procedures described in Example 24:












R5
MW
No.





















 









H3C—
351.38
728


 






487.58
729


 






443.48
730


 






427.48
731


 






393.46
732


 






413.45
733


 






427.48
734


 






481.45
735


 






463.51
736


 






473.51
737


 






441.51
738


 






431.44
739


 






449.43
740


 






481.45
741


 






431.44
742


 






365.41
743


 






506.58
744


 






482.34
745


 






439.49
746


 






497.45
747


 






445.47
748


 






469.56
749


 






485.56
750


 






483.59
751


 






549.45
752


 






455.53
753


 






455.53
754


 






427.48
755


 






431.44
756


 






463.51
757


 






539.70
758


 






455.53
759


 






469.56
760


 






405.35
761


 






419.38
762


 






473.51
763


 






419.48
764


 






379.44
765


 






559.64
766


 






485.56
767


 






449.4
768


 






443.4
769


 






431.4
770


 






559.6
771


 






483.5
772


 






438.4
773


 






441.5
774


 






464.5
775


 







776
























447.90
777


 


H3C—
351.38
778


 






487.58
779


 






443.48
780


 






427.48
781


 






393.46
782


 






413.45
783


 






427.48
784


 






473.51
785


 






431.44
786


 






449.43
787


 






481.45
788


 






431.44
789


 






455.49
790


 






365.41
791


 






482.34
792


 






439.49
793


 






497.45
794


 






497.45
795


 






445.47
796


 






469.56
797


 






485.56
798


 






483.59
799


 






549.45
800


 






455.53
801


 






455.53
802


 






427.48
803


 






431.44
804


 






463.51
805


 






491.55
806


 






539.70
807


 






455.53
808


 






469.56
809


 






473.51
810


 






419.48
811


 






485.56
812


 






443.48
813


 






431.44
814


 






559.64
815


 






483.59
816


 






438.46
817


 






481.45
818


 






441.51
819


 






457.46
820


 






457.46
821


 






489.55
822
























447.90
823


 


H3C—
351.38
824


 






487.58
825


 






443.48
826


 






427.48
827


 






393.46
828


 






413.45
829


 






470.50
830


 






427.48
831


 






481.45
832


 






463.51
833


 






473.51
834


 






441.51
835


 






431.44
836


 






449.43
837


 






481.45
838


 






431.44
839


 






455.49
840


 






365.41
841


 






506.58
842


 






482.34
843


 






439.49
844


 






497.45
845


 






497.45
846


 






445.47
847


 






469.56
848


 






485.56
849


 






483.59
850


 






549.45
851


 






455.53
852


 






455.53
853


 






427.48
854


 






431.44
855


 






463.51
856


 






491.55
857


 






539.70
858


 






455.53
859


 






469.56
860


 






473.51
861


 






419.48
862


 






559.64
863


 






485.56
864


 






449.43
865


 






443.48
866


 






431.44
867


 






559.64
868


 






483.59
869


 






438.46
870


 






481.4
871


 






441.5
872


 






464.5
873


 






457.4
874


 






489.5
875









EXAMPLE 25
2-{2-[(4-Nitrophenoxy)ethoxy]}phenylacetic acid
18.5 g (0.12 M) of 2-hydroxyphenylacetic acid and 13.7 g (0.12 M) of potassium hydroxide are added to 120 ml of methanol in a 500 ml reactor. After stirring for 10 minutes, 30 g (0.12 M) of -(4-nitrophenoxy)ethyl bromide are added and the reaction medium is then refluxed for 24 hours with stirring. The methanol is evaporated off and the residue is taken up in water. The aqueous phase obtained is first washed with ethyl acetate and then acidified with dilute aqueous hydrochloric acid and extracted with ethyl acetate.
The organic phase is evaporated under vacuum and the residue obtained is purified by chromatography on silica, with a dichloromethane/acetone mixture (95/5) as eluent. After concentrating, 9 g of a beige-coloured solid are obtained (yield: 23%).
NMR (δ in ppm, DMSO, 200 MHz): 3.7 (s, 2H); 4.53 (s, 2H); 4.64 (s, 2H); 7.09 (m, 2H); 7.24 (m, 2H); 7.40 (m, 2H); 8.41 (m, 2H); 12.29 (s, 1H).
EXAMPLE 26
2-{2-(4-Aminophenoxy)ethoxy]}phenylacetic acid
9 g (0.028 M) of 2-{2-[(4-nitrophenoxy)ethoxy]}phenylacetic acid and 0.9 g of wet 10% palladium-on-charcoal are added to 60 ml of tetrahydrofuran in a 500 ml reactor. The reaction medium is then stirred vigorously for 3 hours under ambient pressure of hydrogen: exothermicity is observed and the temperature of the reaction medium rises to 40° C.
The reaction medium is then filtered through Celite and concentrated under vacuum to give a residue, which is taken up in diethyl ether. 6.5 g of a light brown solid are thus obtained (80% yield).
NMR (δ in ppm, DMSO, 200 MHz): 3.74 (s, 2H); 4.33 (t, 2H); 4.42 (t, 2H); 7.2 (multiplet, 8H).
EXAMPLE 27
2-{2-[4-(4-[2-Methylethyl)phenyl]sulfonylamino)phenoxy-ethoxy}phenylacetic acid
100 mg (0.348 mM) of 2-[2-(4-aminophenoxy)ethoxy]phenylacetic acid, 0.056 ml (0.694 mM) of pyridine and 61.5 mg (0.348 mM) of 4-(2-methylethyl)benzenesulfonyl chloride are added to 0.3 ml of dimethylformamide in a 15 ml reactor.
The reaction medium is then stirred for 24 hours at room temperature, and then acidified with 3 ml of 3N hydrochloric acid. The mixture is extracted with ethyl acetate to give, after evaporation, 29.7 mg of 2-{2-[4-(4-(2-methylethyl)-phenylsulfonylamino)phenoxy]ethoxy}phenylacetic acid (yield: 18.5%).
NMR (δ in ppm, DMSO, 200 MHz): 1.3 (d, 6H); 3.05 (m, 1H); 3.63 (s, 2H); 4.35 (m, 4H); 7.4 (multiplet, 12H); 10.05 (s, 1H); 12.25 (s, 1H).
By way of example, the following compounds are prepared according to the procedures described in Example 27:
















 









R5
MW
No.
















461.92
876


 






457.51
877


 






407.49
878


 






427.48
879


 






484.53
880


 






441.51
881


 






495.48
882


 






487.53
883


 






455.53
884


 







885


 






495.4
886


 






445.4
887


 






469.5
888


 






379.4
889


 






520.6
890


 






496.3
891


 






453.5
892


 






511.4
893


 






511.48
894


 






459.50
895


 






483.59
896


 






499.59
897


 






497.62
898


 






563.48
899


 






469.56
900


 






469.56
901


 






441.51
902


 






445.47
903


 






477.54
904


 






505.57
905


 






553.72
906


 






469.56
907


 






483.59
908


 






487.53
909


 






433.51
910


 






573.67
911


 






463.46
912


 






457.51
913


 






445.47
914


 






573.67
915


 






497.62
916


 






452.49
917


 






495.48
918


 






455.53
919


 






478.53
920


 






471.49
921


 






503.58
922









EXAMPLE 28
2-[2-(4-Nitrophenoxy)ethoxy]phenylpropanoic acid
25 g (0.15 M) of 2-hydroxyphenylpropanoic acid and 16.9 g (0.12 M) of potassium hydroxide are added to a mixture of 150 ml of methanol and 20 ml of dimethylformamide in a 1000 ml reactor. After stirring for 10 minutes, 30 g (0.15 M) of 2-(4-nitrophenoxy)ethyl bromide are added and the reaction medium is then refluxed for 24 hours with stirring. The methanol is evaporated off and the residue is taken up in water. The aqueous phase obtained is first washed with ethyl acetate and then acidified with dilute aqueous hydrochloric acid and extracted with ethyl acetate.
The organic phase is evaporated under vacuum and the residue obtained is purified by chromatography on silica, with a dichloromethane/methanol mixture (95/5) as eluent. After concentrating, 9 g of a beige-coloured solid are obtained (yield: 23%).
NMR (δ in ppm, DMSO, 200 MHz): 2.33 (t, 2H); 2.58 (t, 2H); 4.20 (s, 2H); 4.35 (s, 2H); 6.8 (multiplet, 6H); 8.06 (d, 2H).
EXAMPLE 29
2-[2-(4-Aminophenoxy)ethoxy]phenylpropanoic acid
8.4 g (0.025 M) of 2-[2-(4-nitrophenoxy)ethoxy]phenylpropanoic acid and 0.9 g of wet 10% palladium-on-charcoal are added to 60 ml of tetrahydrofuran in a 500 ml reactor. The reaction medium is then stirred vigorously for 3 hours under ambient pressure of hydrogen: exothermicity is observed and the temperature of the reaction medium rises to 40° C.
The reaction medium is then filtered through Celite and concentrated under vacuum to give a residue, which is taken up in diethyl ether. 6.5 g of a light brown solid are thus obtained (80% yield).
NMR (δ in ppm, DMSO, 200 MHz): 2.55 (t, 2H); 2.8 (t, 2H); 4.25 (m, 4H); 6.85 (multiplet, 8H).
EXAMPLE 30
2-{2-[4-(Methylsulfonylamino)phenoxy]ethoxy}phenylpropanoic acid
38 mg (0.332 mM) of methanesulfonyl chloride are added to a mixture of 0.25 ml of dimethylformamide and 1.5 ml of tetrahydrofuran in a 15 ml reactor. 100 mg (0.332 mM) of 2-{2-(4-aminophenoxy)ethoxy}phenylpropanoic acid are then added, followed by addition of 0.060 ml (0.74 mM) of pyridine. The reaction medium is then stirred for 48 hours at room temperature. After extraction with ethyl acetate, 20 mg of 2-{2-[4-(methylsulfonylamino)phenoxy]ethoxy}phenyl-propanoic acid are obtained (yield: 16%).
NMR (δ in ppm, DMSO, 200 MHz): 2.8 (t, 2H); 3.05 (t, 2H); 4.6 (m, 4H); 7.3 (multiplet, 8H).
By way of example, the following compounds are prepared according to the procedures described in Example 30.
In particular, the corresponding compounds of the type —NH—CO(R5) (Examples 966 to 1004) may be prepared from the corresponding compounds so of the type —NH2 according to the method described in Example 15.












R5
MW
No.
































475.95
923


 


H3C—
379.44
924


 






515.63
925


 






471.53
926


 






421.52
927


 






441.51
928


 






498.56
929


 






455.53
930


 






509.51
931


 






491.57
932


 






501.56
933


 






469.56
934


 






459.50
935


 






477.49
936


 






509.51
937


 






459.50
938


 






483.54
939


 






393.46
940


 






534.64
941


 






467.55
942


 






525.50
943


 






525.50
944


 






473.52
945


 






497.62
946


 






513.61
947


 






511.64
948


 






577.5
949


 






483.5
950


 






483.5
951


 






455.5
952


 






459.5
953


 






491.5
954


 






519.6
955


 






483.5
956


 






497.6
957


 






501.56
958


 






587.69
959


 






513.61
960


 






477.49
961


 






471.53
962


 






509.51
963


 






469.56
964


 






517.61
965
























407.43
966


 






433.51
967


 






373.37
968


 






425.87
969


 






411.85
970


 






395.39
971


 






357.41
972


 






407.43
973


 






391.43
974


 






357.41
975


 






391.43
976


 






391.43
977


 






413.38
978


 






399.49
979


 






405.45
980


 






421.45
981


 






345.36
982


 






383.45
983


 






343.38
984


 






369.42
985


 






397.48
986


 






407.43
987


 






377.40
988


 






371.44
989


 






411.85
990


 






395.39
991


 






456.30
992


 






355.39
993


 






383.43
994


 






367.36
995


 






407.43
996


 






427.55
997


 






413.52
998


 






371.44
999


 






357.41
1000


 






391.43
1001


 






403.44
1002


 






425.87
1003


 






393.40
1004









Examples of Biological Activity:

Insulin Secretion Test on INS-1 Cells
According to the method described in Endocrinology, 1992 vol. 130 (1) pp. 167-178














INS-1 Test concen-


Structure
Number
tration 10−5 M %











159
269


 






163
259


 






168
256


 






157
203


 






152
202


 






144
191


 






151
190


 






158
182


 






164
180


 






121
184


 






117
175


 






109
162


 






654
148


 






655
147


 






639
144


 






642
140


 






650
139









Sec INS corresponds to the percentage of insulin secretion.
C corresponds to the concentration of test compound according to the invention.
Insulin Secretion Test on Islets Isolated from Rats
The effect of the compounds on insulin secretion as a function of the glucose concentration was tested, in vitro, in isolated islets of Langerhans in static incubation.
The islets Langerhans obtained by digestion of exocrine pancreatic tissue with collagenase, followed by purification on a Ficoll gradient, are incubated for 90 minutes in the presence of two concentrations of glucose (2.8 mM or 8 mM), in the presence or absence of the chemical compound. The insulin secretion is assayed by RIA in the incubation medium.
The potential of the various chemical compounds to stimulate insulin secretion is estimated by calculating the stimulation factor*.
A compound stimulates insulin secretion if this factor is greater than or equal to 130% for a given dose of glucose.




  
    
      
        
      
      *
    
    ⁢
    NB
    :
    
      Stimulation
      ⁢
      
        
          
        
        ⁢
        
          
        
      
      ⁢
      factor
    
  
  =
  
    
      
        (
        
          G
          +
          P
        
        )
      
      *
      100
    
    G
  




In which:

G=insulin secretion (pmol/min. islet) in the presence of glucose alone
G+P=insulin secretion (pmol/min. islet) in the presence of the same concentration of glucose and of the test compound.















Isolated
Isolated islets


Structure
Number
islets 10−5 M
10−7 M











158
+166%
+135%


 






163
+223%
+160%


 






168
+236%
+169%









In Vivo Test
Objective:
To evaluate the effect of 2-{2-[4-(4-chlorobenzenesulfonylamino)phenyl]-ethyl}benzoic acid (compound 522) on the glucose tolerance of n0-STZ/sucrose rats, after a daily treatment for 7 days.
Animals and Treatment:
Rats Wistar (origin: Charles River, France), which received an injection of streptozotocin (100 mg/kg i.v.) on the day of birth. On their arrival at the Research Centre, at seven weeks old:


    
    
        9 rats were placed on a standard diet (A04, SAFE).
        19 rats were placed on a sucrose-rich diet (58% sucrose, SAFE).
    
    


After 2 months on the diet, the rats on the sucrose diet were divided randomly into 2 subgroups (control diabetic, treated diabetic).
The three groups were then treated daily for 7 days, with excipient (0.5% methylcellulose solution) for the control group (healthy animals) and the diabetic control group, or with product (compound 522, 100 mg/kg/day) for the third group.
Glucose Tolerance Test (OGTT):
After treatment for 7 days, the animals were fasted for 3 hours before the start of the test. Samples were taken from the tail of the conscious rats. The first blood sample was taken 10 minutes before the administration of glucose (2 g/kgbody weight/oral route). Blood was then taken 10, 20, 30, 45, 60, 90 and 120 minutes after the administration of glucose.
The glucose tolerance was evaluated by means of the ΔAUC glc, which represents the cumulative increase in glycaemia above the basal value over the 120 minutes of the test.
The insulin response to glucose was estimated by means of the ΔAUC Ins, which represents the cumulative increase in insulinaemia above the basal value over the 120 minutes of the test.
Results:
FIG. 1 represents the ΔAUC glucose, which is down by 21% (significant: p<0.05) on the treated rats (26438+/−2255) compared with the diabetic controls (33306+/−1403 mg/dl·min).
FIG. 2 represents the unchanged ΔAUC insulin (Treated: 14494+/−665, Diabetic Controls: 11417+/−1440 pmol·min).

## Claims

1. A compound of the formula (1):




wherein:
B and E are both each a —CH2— group or are both each an oxygen atom;
R1 is:
H, or
(C1-C8)alkyl which is optionally substituted by one or more groups chosen independently from halogen, (C1-C5)alkyl, (C1-C5)alkoxy, (C3-C8)cycloalkyl and (C6-C14)aryl

R2 and R2′ are each:
H;

R3 is:
H, or
(C1-C20)alkyl;

R4 is:




R5 is Z;
D is a single bond or a (C1-C6)alkyl group;
A is a single bond;
Z is in each case:
(C1-C20)alkyl which is optionally substituted by one or more groups X;
(C2-C20)alkene which is optionally substituted by one or more groups X;
(C2-C20)alkyne which is optionally substituted by one or more groups X;
(C6-C14)aryl, (C6-C14)aryl(C1-C5)alkoxy, (C6-C14)aryloxy or (C6-C14)aryloxy(C1-C5)alkoxy, the aryl group of each of these groups being optionally substituted by one or more groups X;
—(C3-C8)cycloalkyl which is optionally substituted by one or more groups X;
(C3-C8)heterocycle comprising one or more hetero atoms chosen from N, O and S and which is optionally substituted by one or more groups X;
(C6-C14)aryl(C1-C20)alkyl, (C6-C14)aryl(C2-C20)alkene or (C6-C14)aryl-(C2-C20)alkyne, the aryl group of each of these groups being optionally substituted by one or more groups X;
(C5-C13)heteroaryl and (C5-C13)heteroaryl(C1-C20)alkyl comprising one or more hetero atoms chosen from N, O and S, the heteroaryl group of each of these groups being optionally substituted by one or more groups X;
(C3-C8)cycloalkyl(C1-C20)alkyl, (C3-C8)cycloalkyl(C2-C20)alkene or (C3-C8)cycloalkyl(C2-C20)alkyne, the cycloalkyl group of each of these groups being optionally substituted by one or more groups X;
X is in each case amino, hydroxyl, thio, halogen, cyano, nitro, trifluoromethoxy, trifluoromethyl, carboxyl, carboxymethyl or carboxyethyl, (C1-C8)alkyl, (C1-C8)-alkoxy, (C1-C8)alkylthio, (C1-C8)alkylamino, (C6-C14)aryl, (C6-C14)arykl(C1-C8)-sulfonylalkyl, (C6-C14)aryloxy, (C6-C14)aryl(C1-C8)alkoxy, —NHCO(C1-C8)alkyl, —N—(C1-C8)alkylCO(C1-C8)alkyl, —CO(C1-C8)alkyl, —SO2(C6-C14)aryl, di(C1-C8)alkylamino, (C3-C8)cycloalkyl or a ketone function;
n and n′ are each independently 1, 2 or 3,
or a tautomeric form, enantiomer, diastereoisomer or epimer thereof, or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1, wherein B and E are each a —CH2— group.

3. A compound according to claim 1, wherein R1 is a hydrogen atom.

4. A compound according to claim 1, wherein X is in each case hydroxyl, halogen, cyano, nitro, trifluoromethoxy, trifluoromethyl, carboxyl, (C1-C8)alkyl, —SO2(C6-C14)aryl, (C1-C8)alkoxy, di(C1-C8)alkylamino, —NHCO(C1-C8)alkyl, —N—(C1-C8)alkylCO(C1-C8)alkyl, —CO(C1-C8)alkyl or (C6-C14)aryl(C1-C8)alkoxy or a ketone function.

5. A compound according to claim 1, wherein Z is (C1-C20)alkyl, (C6-C14)aryl, (C3-C8)cycloalkyl, (C6-C14)aryl(C1-C20)alkyl or (C1-C13)heteroaryl, which in each case is optionally substituted by one or more groups.

6. A compound according to claim 1, wherein R3 is H or (C1-C8)alkyl.

7. A compound according to claim 1, wherein R5 is (C1-C20)alkyl, (C6-C14)aryl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C20)alkyl, (C6-C14)aryl(C1-C20)alkyl or (C1-C13)heteroaryl, which in each case is optionally substituted by one or more groups.

8. A compound according to claim 1, wherein said compound is of formula (2) or (2′) in which the group -A-COOR1 is in an ortho or meta position on the ring relative to E:

9. A compound according to claim 1, wherein if -ACOOR1 is in the para position, then —NR3R4 is in the para or meta position relative to the chain B-D-E.

10. A compound according to claim 1, wherein if -ACOOR1 is in the para position, then —NR3R4 is in an ortho position relative to the chain B-D-E, and R2 is H.

11. A compound according to claim 1, wherein said compound is of such that they have a general formula (3) which the function NR3R4 is in a meta position on the ring relative to B:

12. A compound according to claim 1, wherein said compound is of formula (4) in which the function NR3R4 is in the para position on the ring relative to B:

13. A compound according to claim 1, wherein B and E are each a —CH2— group and D is a single bond or a —CH2 group.

14. A compound according to claim 1, wherein B and E are each an oxygen atom and D is a —C2H4 group.

15. A compound according to claim 1, wherein B and E are each a —CH2— group, D is a chain containing 3 carbon atoms.

16. A compound selected from:
4-{2-[2-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-[2-(2-methanesulfonylaminophenyl)ethyl]benzoic acid
4-{2-[2-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-[2-(2-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
4-{2-[2-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
4-[2-(2-benzenesulfonylaminophenyl)ethyl]benzoic acid
4-{2-[2-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(4-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(4-fluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
4-{2-[2-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(4-methoxy-2,5,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(hexadecane-1-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(3-fluoro-6-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2,3,4,5,6-pentamethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(3-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-(2-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
4-{2-[2-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[2-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenyl]ethyl}benzoic acid
4-(2-{2-[(4-acetylaminobenzenesulfonyl)butylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(4-chlorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(4-methoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(2-nitrobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(toluene-4-sulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(3-trifluoromethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(naphthalene-1-sulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(2,5-dimethoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(2,4-dimethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(2-fluorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(2,4-difluorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[(4-acetylbenzenesulfonyl)butylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(4-methoxy-2,3,6-trimethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(5-dimethylaminonaphthalene-1-sulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(naphthalene-2-sulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[(2-acetylamino-4-methylthiazole-5-sulfonyl)butylamino]phenyl}ethyl)benzoic acid
4-{2-[2-(benzenesulfonylbutylamino)phenyl]ethyl}benzoic acid
4-(2-{2-[butyl(2,5-dichlorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(2,4,6-trimethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(4-tert-butylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl((E)-2-phenylethenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(3,4-dimethoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(4-trifluoromethoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(thiophene-2-sulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[(5-benzenesulfonylthiophene-2-sulfonyl)butylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(2-trifluoromethoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[(4-butoxybenzenesulfonyl)butylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(5-fluoro-2-methylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(2,6-difluorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(4-butylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(3-methoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-{2-[2-(butylpentamethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-(2-{2-[(3,5-bis-trifluoromethylbenzenesulfonyl)butylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(4-propylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(4-isopropylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(3-fluorobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(toluene-3-sulfonyl)amino]phenyl}ethyl)benzoic acid
4-[2-(2-{butyl-[4-(1,1-dimethylpropyl)benzenesulfonyl]amino}phenyl)ethyl]benzoic acid
4-(2-{2-[butyl(2-cyanobenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(4-ethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[butyl(4-trifluoromethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[(4-chlorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(toluene-4-sulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(3-trifluoromethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(naphthalene-1-sulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[(2,5-dimethoxybenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[(2,4-dimethylbenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[(2-fluorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[(2,4-difluorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(2-trifluoromethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[(4-fluorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[(4-acetylbenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(4-methoxy-2,3,6-trimethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(naphthalene-2-sulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[(2-acetylamino-4-methylthiazole-5-sulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-{2-[2-(benzenesulfonylheptylamino)phenyl]ethyl}benzoic acid
4-(2-{2-[heptyl((E)-2-phenylethenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[(3,4-dimethoxybenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(4-trifluoromethoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(quinoline-8-sulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[(5-fluoro-2-methylbenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[(2,6-difluorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[(4-butylbenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(3-methoxybenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(4-propylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(4-isopropylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-(2-{2-[(3-fluorobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(toluene-3-sulfonyl)amino]phenyl}ethyl)benzoic acid
4-[2-(2-{[4-(1,1-dimethylpropyl)benzenesulfonyl]-heptylamino}phenyl)ethyl]benzoic acid
4-(2-{2-[(2-cyanobenzenesulfonyl)heptylamino]phenyl}ethyl)benzoic acid
4-(2-{2-[heptyl(4-trifluoromethylbenzenesulfonyl)amino]phenyl}ethyl)benzoic acid
4-{2-[3-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-[2-(3-methanesulfonylaminophenyl)ethyl]benzoic acid
4-{2-[3-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-[2-(3-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
4-{2-[3-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
4-[2-(3-benzenesulfonylaminophenyl)ethyl]benzoic acid
4-{2-[3-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(2-trifluoro-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(ethanesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-(2-{3-[4-(1,1-dimethylethyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
4-{2-[3-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(biphenyl-4-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(2,5-dichlorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
4-{2-[3-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-((E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-[2-(3-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
4-{2-[3-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-(2-{3-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
4-{2-[3-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[3-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-[2-(4-methanesulfonylaminophenyl)ethyl]benzoic acid
4-{2-[4-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-[2-(4-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
4-{2-[4-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
4-[2-(4-benzenesulfonylaminophenyl)ethyl]benzoic acid
4-{2-[4-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(4-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(ethanesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2,3,4,5,6-pentamethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(3-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
4-{2-[4-(propane-2-sulfonylamino)phenyl}ethyl]benzoic acid
4-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
4-{2-[4-(4-butoxybenzenesulfonylamino)phenyl}ethyl]benzoic acid
4-{2-[4-(2,6-difluorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
4-{2-[4-(3-methoxybenzenesulfonylamino)phenyl}ethyl]benzoic acid
4-{2-[4-(3-fluorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
4-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
4-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
4-{2-[4-(2-cyanobenzenesulfonylamino)phenyl}ethyl]benzoic acid
4-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[2-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-[2-(2-methanesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[2-(4-methoxybenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-[2-(2-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[2-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
3-[2-(2-benzenesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[2-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[2-(naphthalene-1-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(2,4-difluorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[2-(4-fluorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[2-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[2-(biphenyl-4-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(4-acetylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-[2-(2-ethanesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(hexadecane-1-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(quinoline-8-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-[2-(2-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
3-(2-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
3-{2-[2-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenyl]ethyl})benzoic acid
3-{2-[2-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[2-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-[2-(3-methanesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[3-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-[2-(3-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[3-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
3-[2-(3-benzenesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[3-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(3-trifluoromethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(naphthalene-1-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(2,5-dimethoxybenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(2-fluorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(2,4-difluorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(2-trifluoromethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(4-fluorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(biphenyl-4-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(4-acetylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-[2-(3-ethanesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[3-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(naphthalene-2-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(2,5-dichlorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(2,4,6-triisopropylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(2,4,6-trimethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-((E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(3,4-dimethoxybenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(propane-2-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(2,2,2-trifluoroethanesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(quinoline-8-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(4-butoxybenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(5-fluoro-2-methylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(2,6-difluorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(4-butylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(3-methoxybenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-[2-(3-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[3-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(3-fluorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[3-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
3-(2-{3-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
3-{2-[3-(2-cyanobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(4-ethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(4-trifluoromethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[3-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-[2-(4-methanesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[4-(4-methoxybenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-[2-(4-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[4-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
3-[2-(4-benzenesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[4-(4-acetylaminobenzenesulfonyl amino)phenyl]ethyl}benzoic acid
3-{2-[4-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(4-acetylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-[2-(4-ethanesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[4-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(naphthalene-2-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(2,5-dichlorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-((E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(quinoline-8-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(4-butoxybenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(2,6-difluorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(4-butylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(3-fluorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
3-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
3-{2-[4-(2-cyanobenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(4-ethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenyl]ethyl}benzoic acid
3-{2-[4-(naphthalene-1-sulfonylamino)phenyl}ethyl]benzoic acid
3-[2-(4-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
3-{2-[4-(4-propylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
3-{2-[4-(4-isopropylbenzenesulfonylamino)phenyl}ethyl]benzoic acid
2-{2-[2-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
2-{2-[2-(biphenyl-4-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(2-ethanesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(quinoline-8-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(2-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-(2-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
2-{2-[2-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(2-methanesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[2-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(2-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[2-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(2-benzenesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[2-(4-acetylaminobenzenesulfonyl amino)phenyl]ethyl}benzoic acid
2-{2-[2-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[2-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-acetylaminobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
2-{2-[3-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(2,5-dichlorobenzenesulfonylamino)phenyl}ethyl]benzoic acid
2-{2-[3-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(3-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[3-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-(2-{3-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
2-{2-[3-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(3-methanesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[3-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(3-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[3-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(3-benzenesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[3-(2-nitrobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[3-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-acetylaminobenzenesulfonyl amino)phenyl]ethyl}benzoic acid
2-{2-[4-(toluene-4-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(naphthalene-1-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(2-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(2,4-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl}ethyl]benzoic acid
2-{2-[4-(biphenyl-4-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-acetylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(4-ethanesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[4-(naphthalene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(2,5-dichlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-tert-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(E)-2-phenylethenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(thiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-carboxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(propane-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-butoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(2,6-difluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(3-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(4-pentamethylbenzenesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(3-fluorobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(toluene-3-sulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]ethyl}benzoic acid
2-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}ethyl)benzoic acid
2-{2-[4-(2-cyanobenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-ethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-chlorobenzenesulfonyl amino)phenyl]ethyl}benzoic acid
2-[2-(4-methanesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[4-(4-methoxybenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(4-phenylmethanesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[4-(butane-1-sulfonylamino)phenyl]ethyl}benzoic acid
2-[2-(4-benzenesulfonylaminophenyl)ethyl]benzoic acid
2-{2-[4-(2-nitrobenzenesulfonyl amino)phenyl]ethyl}benzoic acid
2-{2-[4-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4(4-propylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(4-isopropylbenzenesulfonylamino)phenyl]ethyl}benzoic acid
2-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenyl}ethyl]benzoic acid
2-{3-[2-(4-acetylaminobenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(4-chlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(4-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(2-nitrobenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(toluene-4-sulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(naphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(2-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(2,4-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(4-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(5-chloro-3-methylbenzo[b]thiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(biphenyl-4-sulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(4-acetylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(naphthalene-2-sulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]propyl}benzoic acid
2-[3-(2-benzenesulfonylaminophenyl)propyl]benzoic acid
2-{3-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(4-isopropylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-((E)-2-phenylethenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(4-carboxybenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(4-butoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(2,6-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(4-butylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(3-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
2-[3-(2,3,4,5,6-pentamethylbenzenesulfonylaminophenyl)propyl]benzoic acid
2-{3-[2-(4-propylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(4-isopropylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(3-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(toluene-3-sulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-acetylaminobenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-chlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
3-[3-(2-methanesulfonylaminophenyl)propyl]benzoic acid
3-{3-[2-(4-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(2-nitrobenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(toluene-4-sulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(naphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
3-[3-(2-phenylmethanesulfonylaminophenyl)propyl]benzoic acid
3-{3-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(2-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(2,4-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(biphenyl-4-sulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-acetylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-[3-(2-ethanesulfonyl aminophenyl)propyl]benzoic acid
3-{3-[2-(butane-1-sulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(naphthalene-2-sulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]propyl}benzoic acid
3-[3-(2-benzenesulfonylaminophenyl)propyl]benzoic acid
3-{3-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-tert-butylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-[3-(2-trifluoromethanesulfonylaminophenyl)propyl]benzoic acid
3-{3-[2-((E)-2-phenylethenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(thiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(propane-2-sulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-butoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(2,6-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-butylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(3-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
3-[3-(2-pentamethylbenzenesulfonylaminophenyl)propyl]benzoic acid
3-{3-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-propylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-isopropylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(3-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(toluene-3-sulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
3-(3-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}propyl)benzoic acid
3-{3-[2-(2-cyanobenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-ethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
3-{3-[2-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenyl]-propyl}benzoic acid
4-{3-[2-(4-acetylaminobenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-chlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
4-[3-(2-methanesulfonylaminophenyl)propyl]benzoic acid
4-{3-[2-(4-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(2-nitrobenzenesulfonyl amino)phenyl]propyl}benzoic acid
4-{3-[2-(toluene-4-sulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(naphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
4-[3-(2-phenylmethanesulfonylaminophenyl)propyl]benzoic acid
4-{3-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(2-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(2,4-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(biphenyl-4-sulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-acetylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-[3-(2-ethanesulfonylaminophenyl)propyl]benzoic acid
4-{3-[2-(butane-1-sulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(naphthalene-2-sulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenyl]propyl}benzoic acid
4-[3-(2-benzenesulfonylaminophenyl)propyl]benzoic acid
4-{3-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-tert-butylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(E)-2-phenylethenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(thiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(propane-2-sulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-butoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(2,6-difluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-butylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(3-methoxybenzenesulfonylamino)phenyl]propyl}benzoic acid
4-[3-(2,3,4,5,6-pentamethylbenzenesulfonylaminophenyl)propyl]benzoic acid
4-{3-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-propylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-isopropylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(3-fluorobenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(toluene-3-sulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]propyl}benzoic acid
4-(3-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}propyl)benzoic acid
4-{3-[2-(2-cyanobenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-ethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
4-{3-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{5-[2-(4-acetylaminobenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-chlorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-[5-(2-methanesulfonylaminophenyl)pentyl]benzoic acid
2-{5-[2-(4-methoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-nitrobenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(toluene-4-sulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3-trifluoromethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(naphthalene-1-sulfonylamino)phenyl]pentyl}benzoic acid
2-[5-(2-phenylmethanesulfonylaminophenyl)pentyl]benzoic acid
2-{5-[2-(2,5-dimethoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-fluorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2,4-difluorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-trifluoromethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-fluorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-acetylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-[5-(2-ethanesulfonylaminophenyl)pentyl]benzoic acid
2-{5-[2-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(naphthalene-2-sulfonylamino)phenyl]pentyl}benzoic acid
2-[5-(2-benzenesulfonylaminophenyl)pentyl]benzoic acid
2-{5-[2-(2,5-dichlorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2,4,6-triisopropylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-tert-butylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3,4-dimethoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-trifluoromethoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(thiophene-2-sulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(quinoline-8-sulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-trifluoromethoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-butoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2,6-difluorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3-methoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-[5-(2-pentamethylbenzenesulfonylaminophenyl)pentyl]benzoic acid
2-{5-[2-(4-propylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-isopropylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(toluene-3-sulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenyl]pentyl}benzoic acid
2-(5-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenyl}pentyl)benzoic acid
2-{5-[2-(2-carboxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-ethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-trifluoromethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3-methoxybenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-tert-butylbenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3-carboxypropionylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-carboxybutyrylamino)phenyl]pentyl}benzoic acid
2-(5-{2-[2-(4-chlorophenyl)acetylamino]phenyl}pentyl)benzoic acid
2-{5-[2-(4-chlorobenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3,4-dichlorobenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2,6-dichlorobenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-carboxyacetylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-fluorobenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3-phenylpropionylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3-methylbutyrylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-phenoxyacetylamino)phenyl]pentyl}benzoic acid
2-[5-(2-phenylacetylaminophenyl)pentyl]benzoic acid
2-{5-[2-(2,2-dimethylpropionylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-methylbenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-methylbenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3,5-difluorobenzoylamino)phenyl]pentyl}benzoic acid
2-(5-{2-[((1R,2R)-2-phenylcyclopropanecarbonyl)amino]phenyl}pentyl)benzoic acid
2-{5-[2-(2-ethylhexanoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-ethylbenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3,5-dichlorobenzoylamino)phenyl]pentyl}benzoic acid
2-(5-{2-[(naphthalene-2-carbonyl)amino]phenyl}pentyl)benzoic acid
2-{5-[2-(2-benzyloxyacetylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-methoxyacetylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(cyclohexanecarbonylamino)phenyl]pentyl}benzoic acid
2-[5-(2-butyrylaminophenyl)pentyl]benzoic acid
2-{5-[2-(cyclopentanecarbonylamino)phenyl]pentyl}benzoic acid
2-[5-(2-isobutyrylaminophenyl)pentyl]benzoic acid
2-{5-[2-(2-hydroxyacetylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-phenylbutyrylamino)phenyl]pentyl}benzoic acid
2-[5-(2-propionylaminophenyl)pentyl]benzoic acid
2-(5-{2-[2-(4-fluorophenyl)acetylamino]phenyl}pentyl)benzoic acid
2-{5-[2-((S)-2-hydroxypropionylamino)phenyl]pentyl}benzoic acid
2-(5-{2-[2-(4-methoxyphenyl)acetylamino]phenyl}pentyl)benzoic acid
2-{5-[2-(2-ethylbutyrylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-methylpentanoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3-cyclopentylpropionylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-methylbutyrylamino)phenyl]pentyl}benzoic acid
2-(5-{2-[(quinoxaline-2-carbonyl)amino]phenyl}pentyl)benzoic acid
2-{5-[2-(2,3-difluorobenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-fluoro-4-trifluoromethylbenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(3-chlorobenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-methoxybenzoylamino)phenyl]pentyl}benzoic acid
2-[5-(2-benzoylaminophenyl)pentyl]benzoic acid
2-{5-[2-(3,3-dimethylbutyrylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2-chlorobenzoylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-fluorobenzoylamino)phenyl]pentyl}benzoic acid
2-(5-{2-[(naphthalene-1-carbonyl)amino]phenyl}pentyl)benzoic acid
4-{2-[2-(4-acetylaminobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-chlorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-[2-(2-methanesulfonylaminophenoxy)ethoxy]benzoic acid
4-{2-[2-(4-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2-nitrobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(toluene-4-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(3-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(naphthalene-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-[2-(2-phenylmethanesulfonylaminophenoxy)ethoxy]benzoic acid
4-{2-[2-(2,5-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2,4-dimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2,4-difluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(biphenyl-4-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-acetylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-[2-(2-ethanesulfonylaminophenoxy)ethoxy]benzoic acid
4-{2-[2-(butane-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(naphthalene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-[2-(2-benzenesulfonylaminophenoxy)ethoxy]benzoic acid
4-{2-[2-(2,5-dichlorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2,4,6-triisopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2,4,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-tert-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(E)-2-phenylethenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(3,4-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(thiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-carboxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(quinoline-8-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(5-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-butoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(5-fluoro-2-methylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2,6-difluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(3-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-[2-(2-pentamethylbenzenesulfonylaminophenoxy)ethoxy]benzoic acid
4-{2-[2-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-propylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-isopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(3-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(toluene-3-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-(2-{2-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenoxy}ethoxy)benzoic acid
4-{2-[2-(2-carboxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2-cyanobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-ethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-chlorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2[2-(4-methanesulfonylaminophenoxy)ethoxy]benzoic acid
2-{2-[4-(4-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(2-nitrobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(toluene-4-sulfonylamino)phenoxy]ethoxy}benzoic acid
2-[2-(4-phenylmethanesulfonylaminophenoxy)ethoxy]benzoic acid
2-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(2-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(2,4-difluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(biphenyl-4-sulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-acetylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-[2-(4-ethanesulfonylaminophenoxy)ethoxy]benzoic acid
2-{2-[4-(butane-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(naphthalene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenoxy]ethoxy}benzoic acid
2-[2-(4-benzenesulfonylaminophenoxy)ethoxy]benzoic acid
2-{2-[4-(2,5-dichlorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(2,4,6-triisopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-tert-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(E)-2-phenylethenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(thiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-carboxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-butoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(3-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-[2-(4-pentamethylbenzenesulfonylaminophenoxy)ethoxy]benzoic acid
2-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-propylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-isopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(3-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(toluene-3-sulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
2-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenoxy}ethoxy)benzoic acid
2-{2-[4-(2-carboxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(2-cyanobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-ethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
2-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenoxy]ethoxy}benzoic acid
4-[2-(4-methanesulfonylaminophenoxy)ethoxy]benzoic acid
4-{2-[4-(4-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(2-nitrobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(toluene-4-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(naphthalene-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-[2-(4-phenylmethanesulfonylaminophenoxy)ethoxy]benzoic acid
4-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(2-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(2,4-difluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(4-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-[2-(4-ethanesulfonylaminophenoxy)ethoxy]benzoic acid
4-{2-[4-(butane-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(5-dimethylaminonaphthalene-1-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(naphthalene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-[2-(4-benzenesulfonylaminophenoxy)ethoxy]benzoic acid
4-{2-[4-(2,5-dichlorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(2,4,6-triisopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(4-tert-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-[2-(4-trifluoromethanesulfonylaminophenoxy)ethoxy]benzoic acid
4-{2-[4-(E)-2-phenylethenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(thiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(propane-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(2,2,2-trifluoroethanesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(quinoline-8-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(4-butoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(2,6-difluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(4-butylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(3-methoxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-[2-(4-pentamethylbenzenesulfonylaminophenoxy)ethoxy]benzoic acid
4-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(4-propylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(4-isopropylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(3-fluorobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(toluene-3-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}benzoic acid
4-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenoxy}ethoxy)benzoic acid
4-{2-[4-(2-cyanobenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(4-ethylbenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(3,5-dichloro-2-hydroxybenzenesulfonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)phenoxy]ethoxy}benzoic acid
(2-{2-[4-(4-acetylaminobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-chlorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-methoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(toluene-4-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-fluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(biphenyl-4-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-acetylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
{2-[2-(4-ethanesulfonylaminophenoxy)ethoxy]phenyl}acetic acid
(2-{2-[4-(butane-1-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(5-dimethylaminonaphthalene-1-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(naphthalene-2-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
{2-[2-(4-benzenesulfonylaminophenoxy)ethoxy]phenyl}acetic acid
(2-{2-[4-2,5-dichlorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(2,4,6-triisopropylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-tert-butylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-((E)-2-phenylethenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(thiophene-2-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
4-{4-[2-(2-carboxymethylphenoxy)ethoxy]phenylsulfamoyl}benzoic acid
(2-{2-[4-(quinoline-8-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(2,6-difluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-butylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(3-methoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
{2-[2-(4-pentamethylbenzenesulfonylaminophenoxy)ethoxy]phenyl}acetic acid
(2-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-propylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-isopropylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(3-fluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(toluene-3-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
[2-(2-{4-[4-(1,1-dimethylpropyl)benzenesulfonylamino]phenoxy}ethoxy)phenyl]acetic acid
methyl 2-{4-[2-(2-carboxymethylphenoxy)ethoxy]phenylsulfamoyl}benzoate
(2-{2-[4-(2-cyanobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-ethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
(2-{2-[4-(2-nitrobenzenesulfonylamino)phenoxy]ethoxy}phenyl)acetic acid
3-(2-{2-[4-(4-acetylaminobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(4-chlorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-{2-[2-(4-methanesulfonylaminophenoxy)ethoxy]phenyl}propionic acid
3-(2-{2-[4-(4-methoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(toluene-4-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(3-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(naphthalene-1-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(2,5-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(2,4-dimethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(2-fluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(2,4-difluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(4-fluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(biphenyl-4-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(4-acetylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-{2-[2-(4-ethanesulfonylaminophenoxy)ethoxy]phenyl}propionic acid
3-(2-{2-[4-(butane-1-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}-phenyl)propionic acid
3-(2-{2-[4-(5-dimethylaminonaphthalene-1-sulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
3-(2-{2-[4-(naphthalene-2-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(2-acetylamino-4-methylthiazole-5-sulfonylamino)phenoxy]-ethoxy}phenyl)propionic acid
3-{2-[2-(4-benzenesulfonylaminophenoxy)ethoxy]phenyl}propionic acid
3-(2-{2-[4-(2,4,6-trimethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(4-tert-butylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-((E)-2-phenylethenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(3,4-dimethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(4-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(5-benzenesulfonylthiophene-2-sulfonylamino)phenoxy]ethoxy}phenyl)-propionic acid
3-(2-{2-[4-(2-trifluoromethoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(4-butoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(5-fluoro-2-methylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(2,6-difluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(4-butylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(3-methoxybenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-{2-[2-(4-pentamethylbenzenesulfonylaminophenoxy)ethoxy]phenyl}propionic acid
3-(2-{2-[4-(3,5-bis-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}-phenyl)propionic acid
3-(2-{2-[4-(4-propylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(4-isopropylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(3-fluorobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(toluene-3-sulfonylamino)phenoxy]ethoxy}phenyl)propionic acid methyl 2-(4-{2-[2-(2-carboxy-ethyl)phenoxy]ethoxy}phenylsulfamoyl)benzoate
3-(2-{2-[4-(4-ethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(4-trifluoromethylbenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonylamino)-phenoxy]ethoxy}phenyl)propionic acid
3-(2-{2-[4-(2-nitrobenzenesulfonylamino)phenoxy]ethoxy}phenyl)propionic acid
4-{2-[2-(2-hydroxybenzoylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(3-methoxybenzoylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-tert-butylbenzoylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(3-carboxypropionylamino)phenoxy]ethoxy}benzoic acid
4-(2-{2-[2-(4-chlorophenyl)acetylamino]phenoxy}ethoxy)benzoic acid
4-{2-[2-(4-chlorobenzoylamino)phenoxy]ethoxy}benzoic acid
4-(2-{2-[(E)-(3-phenylacryloyl)amino]phenoxy}ethoxy)benzoic acid
4-[2-(2-hexanoylaminophenoxy)ethoxy]benzoic acid
4-[2-(2-decanoylaminophenoxy)ethoxy]benzoic acid
4-{2-[2-(2-fluorobenzoylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(3-methylbutyrylamino)phenoxy]ethoxy}benzoic acid
4-[2-(2-pentanoylaminophenoxy)ethoxy]benzoic acid
4-{2-[2-(2-phenoxyacetylamino)phenoxy]ethoxy}benzoic acid
4-[2-(2-phenylacetylaminophenoxy)ethoxy]benzoic acid
4-{2-[2-(2,2-dimethylpropionylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2-methylbenzoylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-methylbenzoylamino)phenoxy]ethoxy}benzoic acid
4-[2-(2-nonanoylaminophenoxy)ethoxy]benzoic acid
4-{2-[2-(3,5-difluorobenzoylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2-methoxybenzoylamino)phenoxy]ethoxy}benzoic acid
4-(2-{2-[(furan-2-carbonyl)amino]phenoxy}ethoxy)benzoic acid
4-{2-[2-(2-ethylhexanoylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-ethylbenzoylamino)phenoxy]ethoxy}benzoic acid
4-(2-{2-[(thiophene-2-carbonyl)amino]phenoxy}ethoxy)benzoic acid
4-{2-[2-(3-methylbut-2-enoylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2-benzyloxyacetylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2-methoxyacetylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(4-methoxybenzoylamino)phenoxy]ethoxy}benzoic acid
4-[2-(2-benzoylaminophenoxy)ethoxy]benzoic acid
4-{2-[2-(3,3-dimethylbutyrylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(2-chlorobenzoylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(3-cyclopentylpropionylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(cyclohexanecarbonylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(3-fluorobenzoylamino)phenoxy]ethoxy}benzoic acid
4-{2-[2-(3-bromobenzoylamino)phenoxy]ethoxy}benzoic acid
4-[2-(2-butyrylaminophenoxy)ethoxy]benzoic acid
4-{2-[2-(cyclopentanecarbonylamino)phenoxy]ethoxy}benzoic acid, and
4-(2-{2-[((1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl)amino]phenoxy}ethoxy)benzoic acid; and
tautomeric forms, enantiomers, diastereoisomers, epimers, and pharmaceutically acceptable salts thereof.

17. A compound according to claim 1, wherein said compound is:
2-{5-[2-(5-dimethylaminonaphthalene-1-sulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(quinoline-8-sulfonylamino)phenyl]pentyl}benzoic acid
2-[5-(2-ethanesulfonylaminophenyl)pentyl]benzoic acid
2-{5-[2-(2-fluorobenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-methoxybenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-methoxy-2,3,6-trimethylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{5-[2-(4-isopropylbenzenesulfonylamino)phenyl]pentyl}benzoic acid
2-{3-[2-(2,4,6-trimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(naphthalene-2-sulfonylamino)phenyl]propyl}benzoic acid
2-{3-[2-(2,4-dimethylbenzenesulfonylamino)phenyl]propyl}benzoic acid
2-{2-[4-(4-chlorobenzenesulfonylamino)phenyl]ethyl}benzoic acid, or
4-{2-[3-(4-butylbenzenesulfonylamino)phenyl]ethyl}benzoic acid;

or a tautomeric form, enantiomer, diastereoisomer or epimer thereof, or a pharmaceutically acceptable salt thereof.

18. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable excipient.

19. A compound according to claim 1, wherein the chain B-D-E is —CH2—CH2—.

20. A compound according to claim 1, wherein the chain B-D-E is —CH2—CH2—CH2—.

21. A pharmaceutical composition comprising a compound according to claim 16 and a pharmaceutically acceptable excipient.