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                Clinical DevelopmentHematology Centers Program
    Designed to increase access to critical research resources and collaboration in the national multidisciplinary research effort to combat nonmalignant hematologic diseases and to study normal hematopoiesis.
    NIDDK Program Staff
        Shilpa Hattangadi, M.D.
                    Epigenetics, hematopoiesis, and bone marrow failure
                Jenna Norton, Ph.D., M.P.H.
                    Health equity, social determinants of health & health data standards
    Funding for Hematology Centers
NIDDK funds Cooperative Centers of Excellence in Hematology via U54. The most recent funding opportunity is RFA-DK-19-005. NIDDK funds a Hematology Central Coordinating Center via U24. The most recent funding opportunity is RFA-DK-19-013.
Resources and Services Available from the Hematology Centers Program
The **Hematology Central Coordinating Center (HCCC)** provides central administrative and communications support for the NIDDK Hematology Centers Program and operates a Pilot and Feasibility Program, supporting pilot research studies that will lead to larger research projects.
**University of Utah**
**Research Aims:** The overarching goal of these programs is to support and expand the national research effort to combat nonmalignant hematologic diseases and focus areas of hematopoiesis.
    Consortium Resources
    Pilot and Feasibility ProgramCooperative Centers of Excellence in Hematology
The Cooperative Centers of Excellence in Hematology (CCEH) generate investigative resources that can be made available to the broader research community. They involve integrated teams of investigators from a wide range of disciplines, share specialized equipment, and serve as regional or national resources. In additional to the national pilot and feasibility program managed by the HCCC, the CCEH may also support pilot and feasibility programs that fund small projects aimed to generate preliminary data for inclusion in larger grant applications as well as short-term enrichment activities.
The CCEH provide a focus for multidisciplinary investigations into gene structure and function; the cellular and molecular mechanisms involved in the production, maturation, and function of blood cells; and the development of strategies to treat nonmalignant hematologic diseases. The CCEH offer unique resources and established hematology expertise through scientific cores on a fee-for-service basis. Each Center has independent opportunities for enrichment activities.
The Hematology Centers Program operates as a consortium, comprised of the HCCC and several CCEH. This consortium is actively engaged to better serve the national hematology community, so visit the consortium website for new opportunities and the latest updates to the Cores.
Center Sites
Below are the currently funded Cooperative Centers of Excellence in Hematology. Please visit the consortium website for additional details.
**Cincinnati Children’s Hospital Medical Center**
**Research Aims:** To apply novel technologies to understand blood cell development and diseases.
    **Activities & Services**
    Xenotransplant and Genome Editing Core
        Single Cell Characterization and Procurement Core
        Gene Delivery Core
        Enrichment Program**Fred Hutchison Cancer Research Center**
**Research Aims:** To advance research in stem cell and transplantation biology.
    **Activities & Services**
    Cell Procurement and Processing
        Cell Manipulation Tools
        Canine Disease Transplantation Model
        Enrichment Program**Indiana University - Purdue University at Indianapolis**
**Research Aims:** To advance research in the regulation of human and murine hematopoiesis at the level of hematopoietic stem and progenitor cells.
    **Activities & Services**
    Experimental Mouse Resource Core
        Flow and Tissue Cytometry Core
        Hypoxia Core
        Enrichment Program**University of Utah**
**Research Aims:** To advance research in iron and heme disorders.
    **Activities & Services**
        
    Iron and Heme Core
        Metabolomics Core
        Protein-Metabolite Interactomics
        Enrichment Program**Yale School of Medicine**
**Research Aims:** To apply innovative, emerging technologies to normal and perturbed hematopoiesis.
    **Activities & Services**
    Cell Preparation and Analysis Core
        Imaging Core
        Animal Modeling Core
        Enrichment Program
Related Links
Innovative Science Accelerator (ISAC) ProgramPorphyria Consortium
    Center for Inherited Disease Research (CIDR)
    ENCODE: Encyclopedia of DNA Elements
    VISION: ValIdated Systematic IntegratiON of hematopoietic epigenomes
    ErythronDB
    NIDDK Active Trials in Hematologic Disease
    View related clinical trials from ClinicalTrials.gov.
    Related Study Sections
    Study sections conduct initial peer review of applications in a designated scientific area. Visit the NIH’s Center for Scientific Review website to search for study sections.Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
    NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
    NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.Additional Research Programs
ResearchTraining
NIDDK supports the training and career development of medical and graduate students, postdoctoral
fellows, and physician scientists through institutional and individual grants.
Learn about NIDDK Research Training Programs
Diversity
Diversity Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity Programs
Small Business
Small Business Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology
Transfer (STTR) programs.
These programs support innovative research conducted by small businesses that has the potential for
commercialization.
Learn about NIDDK Small Business Programs
Human SubjectsResearch
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
Learn about Human Subjects Research
TranslationalResearch
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries
into novel therapeutics.
Learn about NIDDK Translational Research Opportunities

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        Last Reviewed April 2023 Contact Us
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