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Research Programs & Contacts
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-  Gastrointestinal Physiology, Development, & Epithelial Biology 
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# Gastrointestinal Physiology, Development, & Epithelial Biology

        Basic, clinical, and translational research on GI development, diseases, and disorders.    

The Gastrointestinal (GI) Physiology, Development, and Epithelial Biology program supports basic and translational research on the development, structure, and function of the GI tract in health and disease.  This program focuses on GI development, regeneration, and healing, including the role of gastrointestinal stem cells and stem cell differentiation; basic biology of the GI epithelium, including studies on the structure and function of the epithelium, interactions between the epithelium and other components of the GI tract, and the integrity of the epithelium as a barrier; the cellular and molecular mechanisms regulating transport and absorption of water, ions, sugars, amino acids/peptides, lipids, vitamins, and minerals across the epithelium; requirements, bioavailability, and metabolism of nutrients and other dietary components at the organ, cellular, and subcellular levels in normal and diseased states; gut barrier function and permeability and normal and abnormal function of the enteric nervous system, including the structure and function of GI hormones peptides and bile acid metabolism. Also of interest are studies that explore the role of taste receptors in the GI tract in nutrient absorption and other metabolic functions.

## NIDDK Program Staff

          -  Patricia Greenwel, Ph.D.                     Basic and Translational Gastrointestinal Developmental Biology, Stem Cell Biology, Neurogenesis, Epithelial Cell Biology, Lymphatics, and Pathogenesis of HIV-Related Disease                
          -  Padma Maruvada, Ph.D.                     Nutrient Metabolism; Clinical Obesity and Nutrition                
          -  Jose Serrano, M.D., Ph.D.                     Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis; Drug Induced Liver Injury; Clinical Research on GI Diseases                
          -  Terez Shea-Donohue, Ph.D.                     Basic and Translational Neurogastroenterology, Gastrointestinal Motility, Gastrointestinal Barrier Function, Mucosal Immunology and Inflammation                

## Recent Funding Opportunities

View More Recent Funding Opportunities
-  Posted:4/10/2024PA-24-184  Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Required)  Summary 
-  Posted:4/9/2024PA-24-185  Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Not Allowed)  Summary 
-  Posted:4/2/2024PAR-24-206  Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)  Summary 
-  Posted:3/27/2024NOT-OD-24-078  Notice of Special Interest (NOSI): Supporting the Exploration of Cloud in NIH-supported Research  Summary 
-  Posted:3/26/2024RFA-NS-25-012  HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)  Summary 

View More Recent Funding Opportunities

## Related Links

-    NIDDK Active Trials in Gastrointestinal Disease  
View related clinical trials from ClinicalTrials.gov.
 
-    NIH Study Sections  
    Study sections conduct initial peer review of applications in a designated scientific area.    Visit the NIH’s Center for Scientific Review website to search for study sections.    
 

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## Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.

-  Ancillary Studies to Major Ongoing Clinical Studies  to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.    
-  NIDDK Central Repository  for access to clinical resources including data and biospecimens from NIDDK-funded studies.    
-  NIDDK Information Network (dkNET)  for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.    

## Additional Research Programs

### *Research*Training

NIDDK supports the training and career development of medical and graduate students, postdoctoralfellows, and physician scientists through institutional and individual grants.
Learn about NIDDK Research Training Programs

### Diversity

#### Diversity Programs

The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity Programs

### Small Business

#### Small Business Programs

NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business TechnologyTransfer (STTR) programs.These programs support innovative research conducted by small businesses that has the potential forcommercialization.
Learn about NIDDK Small Business Programs

### Human Subjects*Research*

#### Human Subjects Research

NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
Learn about Human Subjects Research

### Translational*Research*

NIDDK provides funding opportunities and resources to encourage translation of basic discoveriesinto novel therapeutics.
Learn about NIDDK Translational Research Opportunities

## Meetings & Workshops

                                dkNET                            
                                                                                Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.                                                                                                                    

                                NIH Regional Seminars on Program Funding and Grants Administration                            
                                                                                Providing education and training for the next generation of biomedical and behavioral scientist                                                                                                                    

                                NIH Small Business (SBIR & STTR) Engage & Connect                            
                                                                                Stay informed about the latest events, or connect through social media.                                                                                                                    

                                View all Meetings & Workshops                            

View all Meetings & Workshops

          -    NIH Common Fund  
Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.
 
          -    Planning to Apply? Register Early  
Registration is required at eRA Commons and grants.gov and can take 4 weeks.