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                    Liver Diseases Genetics & Genomics

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        Disease Biology
                Target Identification
                Assay Development
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                Hit to Lead
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                Pre-Clinical Development
                Clinical DevelopmentLiver Diseases Genetics & Genomics
    Identifying genes that influence normal development, function, and diseases of the liver.
    The Liver Diseases Genetics and Genomics program supports research to identify genes that influence normal development, function, and diseases of the liver.  The program supports research to identify genes that influence disease and related anatomical and physiological traits, as well as research on patterns and regulation of gene expression associated with these traits.  Through research involving human subjects as well as model organisms, the program encourages both genome-wide and candidate-gene-based approaches that exploit naturally occurring genetic variation and artificially induced mutations.  Typical research approaches include genome-wide association, exome and whole-genome sequencing, array- and sequencing-based studies of gene expression and epigenetic marks, integrated analyses of multi-omic (genomic, transcriptomic, proteomic, and metabolomic) data.
    NIDDK Program Staff
        Bonnie Burgess-Beusse, Ph.D.
                    Liver cell, molecular and developmental biology; liver regeneration; bile, bilirubin and cholestasis
                Ludmila Pawlikowska, Ph.D.
                    Genetics and Genomics of Liver and Gastrointestinal Diseases; Obesity and Nutrition
Recent Funding Opportunities
                    View More Recent Funding Opportunities
        Posted:
                                4/2/2024
                            PAR-24-206
                    Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)
                    
                    Summary
                Posted:
                                3/27/2024
                            NOT-OD-24-078
                    Notice of Special Interest (NOSI): Supporting the Exploration of Cloud in NIH-supported Research
                    
                    Summary
                Posted:
                                3/26/2024
                            NOT-OD-24-079
                    Notice of Special Interest: Womens Health Research
                    
                    Summary
                Posted:
                                3/26/2024
                            RFA-NS-25-012
                    HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
                    
                    Summary
                Posted:
                                3/18/2024
                            PAR-24-162
                    Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)
                    
                    SummaryView More Recent Funding Opportunities
Related Links
NIDDK Active Trials in Liver Disease
    View related clinical trials from ClinicalTrials.gov.
    NIH Study Sections
    Study sections conduct initial peer review of applications in a designated scientific area.
    Visit the NIH’s Center for Scientific Review website to search for study sections.Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
    NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
    NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.Additional Research Programs
ResearchTraining
NIDDK supports the training and career development of medical and graduate students, postdoctoral
fellows, and physician scientists through institutional and individual grants.
Learn about NIDDK Research Training Programs
Diversity
Diversity Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity Programs
Small Business
Small Business Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology
Transfer (STTR) programs.
These programs support innovative research conducted by small businesses that has the potential for
commercialization.
Learn about NIDDK Small Business Programs
Human SubjectsResearch
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
Learn about Human Subjects Research
TranslationalResearch
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries
into novel therapeutics.
Learn about NIDDK Translational Research Opportunities

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                                Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.
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    Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.
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        Last Reviewed October 2023 Contact Us
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