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                    Research & Funding
                    Research Programs & Contacts
                    Nutrient Metabolism, Status, & Assessment

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        Disease Biology
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                Pre-Clinical Development
                Clinical DevelopmentNutrient Metabolism, Status, & Assessment
    Basic, clinical, and translational research on the requirements, bioavailability, and metabolism of nutrients and other dietary components.
    The
Nutrient Metabolism, Status, and Assessment program supports basic and clinical
studies related to the absorption, metabolism, bioavailability, and
requirements of nutrients and other dietary components.  This includes
research on processes at the organ, cellular, and subcellular levels in normal
and diseased states.  Suitable studies include those that explore how
the nutritional status of an organism, such as over-nutrition and
under-nutrition, affects physiological and metabolic functions contributing to
the pathophysiology of diseases of interest to the NIDDK.  Specific areas
of interest include the role of gut-brain signals in nutrient sensing;
mechanisms of action/interaction of nutrients within the body; the process of
food digestion in the gastrointestinal tract; and the absorption and transport
of water, ions, sugars, amino acids/peptides, lipids, vitamins, minerals, and
other macromolecules and bioactive components.  Other supported studies
include those that explore modifications of nutrient metabolism and/or status due
to genetic variation, altered gut barrier function, and/or in response to
stress, circadian and diurnal variations, drug use, toxicants, bariatric
surgery and physical activity in health and disease.  The program also
supports studies that explore how dietary modifications affect gene regulation
and expression at the transcriptional, translational, epigenetic, and
functional level, including relevant nutrigenetic and nutrigenomic approaches.
Appropriate
studies explore the impact of dietary modification on the human gut microbiome
and/or dysregulation of gut microbiome on nutrient absorption, gut
barrier function, and permeability and metabolism.  Mechanistic
studies that explore the role of prebiotic and probiotic metabolism
on microbiome compositional and functional changes and host physiology are also
appropriate.
This
program also supports studies that explore mathematical models contributing to
the understanding of whole-body energy balance and metabolism, and of metabolic
fluxes in cells, tissues, and organs.  A particular focus of interest
is on models that allow the integration of data gained from a variety of
technological approaches, such as tracer studies, calorimetry, plasma
hormone/cytokines, metabolomics, genomics, epigenomics, and proteomics, and on
those models that would be of clinical utility, including prediction of plasma
glucose levels in diabetes, nutritional partitioning, nutritional status, and
weight management.

The
program supports research on specific metabolic considerations related to
alternative forms of nutrient delivery and use, such as total parenteral and
enteral nutrition.  Other supported studies involve research for
improving methods to determine dietary intake and compliance, including dietary
recall methodologies and questionnaires; novel approaches for collecting
information on dietary intake, identification and development of biomarkers of
intake and exposure; and the development of methods and assays for assessing
nutritional status and for determining specific nutritional requirements in
health and disease.​​​​​​​​​​​​​​​​​​​​​​
    NIDDK Program Staff
        Mary Evans, Ph.D.
                    Multi-center Clinical Studies in Nutrition & Obesity; Nutrition Obesity Research Centers; Diet & Physical Activity Assessment Methodology
                Padma Maruvada, Ph.D.
                    Nutrient Metabolism; Clinical Obesity and Nutrition
Recent Funding Opportunities
                    View More Recent Funding Opportunities
        Posted:
                                4/10/2024
                            PA-24-184
                    Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Required)
                    
                    Summary
                Posted:
                                4/9/2024
                            PA-24-185
                    Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Not Allowed)
                    
                    Summary
                Posted:
                                4/2/2024
                            PAR-24-206
                    Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)
                    
                    Summary
                Posted:
                                3/27/2024
                            NOT-OD-24-078
                    Notice of Special Interest (NOSI): Supporting the Exploration of Cloud in NIH-supported Research
                    
                    Summary
                Posted:
                                3/26/2024
                            RFA-NS-25-012
                    HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
                    
                    SummaryView More Recent Funding Opportunities
Related Links
NIDDK Active Trials in Digestive Disease
    View related clinical trials from ClinicalTrials.gov.
    NIH Study Sections
    Study sections conduct initial peer review of applications in a designated scientific area.
    Visit the NIH’s Center for Scientific Review website to search for study sections.Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
    NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
    NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.Additional Research Programs
ResearchTraining
NIDDK supports the training and career development of medical and graduate students, postdoctoral
fellows, and physician scientists through institutional and individual grants.
Learn about NIDDK Research Training Programs
Diversity
Diversity Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity Programs
Small Business
Small Business Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology
Transfer (STTR) programs.
These programs support innovative research conducted by small businesses that has the potential for
commercialization.
Learn about NIDDK Small Business Programs
Human SubjectsResearch
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
Learn about Human Subjects Research
TranslationalResearch
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries
into novel therapeutics.
Learn about NIDDK Translational Research Opportunities

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    Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.
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        Last Reviewed October 2023 Contact Us
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