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*** Text Omitted and Filed Separately
Pursuant to a Confidential Treatment Request
Under 17 C.F.R. §§ 200.80(b)(4)
and 240.24b-2
 FOURTH AMENDMENT of the COLLABORATION AGREEMENT
 th IDM Pharma, Inc. Innogenetics N.V.
  
    
    Epimmune and Genencor International, Inc. (GCOR) executed the Agreement and proceeded to work thereunder;
    
    Epimmune and GCOR executed the First Amendment and the Second Amendment;
    
    GCOR assigned this Agreement, amended as aforesaid, to INNX by virtue of an Assignment and, in that capacity, INNX
replaced GCOR as a signatory to the Agreement and continued to work with Epimmune thereunder;
    
    Epimmune and INNX executed the Third Amendment;
    
    Epimmune Inc. combined with IDM S.A. and changed its name to IDM Pharma, Inc.;
    
    IDMI and INNX (hereinafter sometimes individually referred to as the Party and collectively as the Parties) have
successfully collaborated under the Agreement and its various Amendments, as aforesaid; and
    
    The Parties are desirous of extending the Agreement in scope and duration as specified herein under the following terms
and conditions.
  1.
    
    The Parties acknowledge that, as of the Effective Date of this Fourth Amendment, references
to EPMN in the Agreement, as amended by the First Amendment, the Second Amendment, the Third
Amendment and this Fourth Amendment, shall be amended so as to replace EPMN with IDMI.2.
    
    Section 4.1 shall be amended to read, as follows:
 4.1
    
    (a) Funding. Subject to the terms and conditions set forth herein,
during the Collaboration Term Innogenetics shall fund annually up to [...***...] IDMI FTEs
at [...***...]/FTE for the work performed under the Work Plan. This payment is based on
the man-month(s) expended by IDMI in support of the Program.
 (b)
    
    Funding   Extended Term. Subject to the terms and
conditions set forth herein, during the Extended Term Innogenetics shall fund
annually between [...***...] and [...***...] IDMI FTEs at [...***...]/FTE for the work
performed under the Work Plan. This payment is based on the man-month(s)
expended by IDMI in support of the Program.(c)
    
    Funding  Second Extended Term. Subject to the terms and
conditions set forth herein, during the Second Extended Term Innogenetics shall
fund annually between [...***...] and [...***...] IDMI FTEs at [...***...]/FTE for the work
performed under the Work Plan. This payment is based on the man-month(s)
expended by IDMI in support of the Program.
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(d)
    
    Funding  Third Extended Term. Subject to the terms and
conditions set forth herein, during the Third Extended Term Innogenetics shall
fund annually [...***...] IDMI FTEs at [...***...]/FTE for the work performed under the
Work Plan. This payment is based on the man-month(s) expended by IDMI in
support of the Program.
 3.
    
    Section 8.1 shall be amended to read, as follows:
 8.1
    
    (a) Term. This Agreement, unless terminated sooner as provided
elsewhere herein, shall expire on September 1, 2004 (the Term), which term can be
extended by mutual agreement of the Parties.
 (b)
    
    Extended Term. Between September 1, 2003 and September
1, 2004 (the Extended Term), Innogenetics may terminate this Agreement at any
time, by providing three months prior written notice.(c)
    
    Second Extended Term. Between September 2, 2004 and
September 30, 2005 (the Second Extended Term), Innogenetics may terminate this
Agreement at any time, by providing three months prior written notice.(d)
    
    Third Extended Term. Between October 1, 2005 and up to
and including March 30, 2006 (the Third Extended Term), Innogenetics may
terminate this Agreement at any time, by providing three months prior written
notice.
  
    
    Other Terms Remain in Effect.All terms and conditions of the
Collaboration Agreement, as amended in the First Amendment, the
Second Amendment and the Third Amendment, which are not modified
by this Fourth Amendment, shall remain in full force and effect.
From and after the Effective Date of this Fourth Amendment, for
purposes of the Collaboration Agreement, the term Agreement
shall be deemed to mean the Collaboration Agreement as amended by
the First Amendment and the Second Amendment and the Third
Amendment and this Fourth Amendment.
    
    Miscellaneous.This Fourth Amendment shall be governed by and
construed under the laws of the State of California as applied to
agreements among California residents entered into and to be
performed entirely within California. The provisions hereof shall
inure to the benefit of, and be binding upon, the successors and
assigns of INNX and IDMI.3.
    
    Effective Date. This Fourth Amendment shall be effective upon that date on which the last of
the signatures set forth below has been affixed hereto.
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For Innogenetics N.V.:
    
    
    
    For IDM Pharma, Inc.:/s/ Frank Morich
    
    
    
    /s/ Robert De VaereFrank Morich
CEO
Date: 9/28/05
    
    
    
    Robert De Vaere
CFO
Date: 9/28/05/s/ Guy Buyens

Guy Buyens
Chief Therapeutics Officer
Date: 9/28/05
 3