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SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

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FORM 10-K/A

AMENDMENT NO. 1

For Annual and Transition Reports
Pursuant to Sections 13 or 15(d) of the
Securities and Exchange Act of 1934

|/x/ | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|--- | ------------------------------------------------------------------------------------

For the fiscal year ended December 31, 2000

|/ / | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|--- | ----------------------------------------------------------------------------------------

For the transition period from  to

Commission File No. 0-21022

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Shaman Pharmaceuticals, Inc.(Exact name of registrant as specified in its charter)

Delaware
(State or other jurisdiction of incorporation or organization)

94-3095806
(IRS Employer Identification Number)213 East Grand Avenue,
South San Francisco, California
(Address of principal executive offices)

94080
(ZIP Code)


Registrant's telephone number, including area code: 650-952-7070
Securities Registered Pursuant to Section 12(b) of the Act: None
Securities Registered Pursuant to Section 12(g) of the Act:
Common Stock $.001 Par Value(Title of Class)

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Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes /x/  No / /

Indicate
by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (Section 229.405 of this chapter) is not contained herein,
and will not be contained, to the best of registrant's
knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K. / /

The
aggregate market value of the voting stock held by non-affiliates of the Registrant based upon the closing sales price of the Common Stock on the OTC Bulletin Board on
April 6, 2001 was $1,470,706.*

The
number of shares of the Registrant's Common Stock outstanding was 103,464,136 as of April 6, 2001.

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EXPLANATORY NOTE

This Form 10-K/A constitutes Amendment No. 1 to the Registrant's Annual Report on Form 10-K for the year ended
December 31, 2000, originally filed by the Registrant on April 17, 2001, and is being filed solely for the purpose of filing the information required by Part III (Items 10, 11, 12
and 13) to the Form 10-K.

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SHAMAN PHARMACEUTICALS, INC.    FORM 10-K/A  AMENDMENT NO. 1 TO 2000 ANNUAL REPORT    TABLE OF CONTENTS    PART III

|Item 10.   |  | Directors and Executive Officers of the Registrant               |  | 4 
|---------- |  | ---------------------------------------------------------------- |  | --
|Item 11.   |  | Executive Compensation                                           |  | 6 
|Item 12.   |  | Security Ownership of Certain Beneficial Owners and Management   |  | 11
|Item 13.   |  | Certain Relationships and Related Transactions                   |  | 14
|Item 14.   |  | Exhibits, Financial Statements Schedules and Reports on Form 8-K |  | 15
|SIGNATURES |  | 16                                                              

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PART III

All information contained in this Report on Form 10-K reflects a 1-for-20 reverse stock
split of the common stock effected on June 22, 1999 and a 1-for-50 reverse stock split of the common stock effected on January 31, 2000.

Item 10. Directors and Executive Officers of the Registrant

Set forth below is information regarding the Company's executive officers and directors as of April 23, 2001.

|Name                  |  | Age |  | Position                                                                        
|--------------------- |  | --- |  | --------------------------------------------------------------------------------
|Lisa A. Conte         |  | 42  |  | Director, President, Chief Executive Officer, and Chief Financial Officer       
|Steven R. King, Ph.D. |  | 43  |  | Chief Operating Officer and Senior Vice President, Ethnobotany and Conservation 
|Gerald M. Reaven      |  | 72  |  | Senior Vice President, Clinical Research                                        
|Thomas F. White       |  | 42  |  | Senior Vice President, Commercial Strategy and Chief Sales and Marketing Officer
|John W.S. Chow        |  | 49  |  | Vice President, Technical Operations                                            
|Robert W. Scannell    |  | 42  |  | Director                                                                        
|M. David Titus(1)     |  | 43  |  | Director                                                                        
|Nezam Tooloee(1)      |  | 42  |  | Director                                                                        

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Lisa A. Contefounded the Company in May 1989 and currently serves as the Company's President, Chief Executive Officer, Chief
Financial Officer and a director. From 1987 to 1989, Ms. Conte was Vice
President at Technology Funding, Inc., a venture capital firm, where she was responsible for the analysis and management of healthcare industry investments. From 1985 to 1987, she conducted
risk and strategy audits for venture capital portfolio companies at Strategic Decisions Group, a management consulting firm. Ms. Conte received an A.B. in Biochemistry from Dartmouth College,
an M.S. in Physiology/Pharmacology from the University of California, San Diego and an M.B.A. from The Amos Tuck School, Dartmouth College.

Steven R. King, Ph.D.joined Shaman in March 1990. He currently serves as Chief Operating Officer and Senior Vice President,
Ethnobotany and Conservation and is responsible for managing day-to-day operations of the Company. From 1989 to 1990, Dr. King was the chief botanist for Latin America
at Arlington, Virginia's Nature Conservancy. He worked in 1988 as Research Associate for the Committee on Managing Global Genetic Resources at the National Academy of Sciences, and was a Doctoral
Fellow from 1983 to 1988 at The New York Botanical Garden's Institute of Economic Botany. Dr. King received a B.A. in Human Ecology from the College of the Atlantic and M.S. and Ph.D. degrees
in Biology from City University of New York.

Gerald M. Reaven, M.D.joined Shaman as a consultant in February 1995 and became an employee in July 1995. He currently
serves as Senior Vice President, Clinical Research. Dr. Reaven came to Shaman from the Stanford University School of Medicine where he served as a faculty member since 1960 and a Professor of
Medicine since 1970. Over the last 20 years, Dr. Reaven served as head of the Division of Endocrinology and Metabolic Diseases, Division of Gerontology and director of the General
Clinical Research Center. Dr. Reaven also served as head of the Division of Endocrinology,

4

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Gerontology and Metabolism at Stanford University School of Medicine, and Director of the Geriatric Research, Education and Clinical Center, at the Palo Alto Veterans Affairs Medical Center.
Dr. Reaven received his A.B., B.S. and M.D. from the University of Chicago.

Thomas F. Whitejoined Shaman in May 1999 as Senior Vice President, Commercial Strategy, and Chief Sales and Marketing Officer.
His responsibilities also include business development. Prior to joining Shaman, from April 1998 to May 1999, Mr. White served as Executive Vice President, General Manager
Functional Food & Beverages at Weider Nutrition International. Prior to that, from June 1995 to March 1998, he was a Principal in the firm of White, Smith-White & Partners,
a consumer products consulting firm, and from August 1993 to May 1995, he served as Director of Marketing for Pete's Brewing Company. Mr. White received his B.A. in Journalism
from the University of Missouri and his M.S. in Advertising from Northwestern University.

John W.S. Chow, Ph.D.joined Shaman in April 1998 as Vice President of Technical Operations. Prior to joining the Company, from
December 1997 to April 1998, Dr. Chow served as Director, Product and
Technology Evaluation at Bristol-Myers Squibb Company, where he performed technical due diligence toward the acquisition and licensing of various dosage forms and technologies and reviewed and
approved new product specifications. Prior to holding this position, from July 1980 to December 1997, Dr. Chow held other positions, also with Bristol-Myers Squibb Company, where
he was responsible for developing strategies for manufacturing consolidation, facilitating technology transfers of new and existing products, and directing technical operations of an international
plant. Dr. Chow received a B.S. in Pharmacy from Washington State University, a Ph.D. in Pharmaceutical Chemistry from Ohio State University and an M.B.A. in Pharmaceutical/Chemical Studies
from Fairleigh Dickinson University.

Robert W. Scannellbecame a director of the Company in August 2000. Mr. Scannell is founder and President of Tradewinds
Financial Corporation, a California registered investment advisor. Prior to forming Tradewinds Financial Corporation, Mr. Scannell spent eight years as a Vice President in the
Institutional Division of Merrill Lynch Capital Markets. Mr. Scannell holds a BA and MBA from Penn State University and is a Chartered Financial Analyst.

M. David Titusbecame a director of the Company in April 1990. Mr. Titus is currently a General Partner of Windward
Ventures Management, L.P. ("Windward"), a venture capital firm, which he founded in November 1997. Prior to founding Windward, Mr. Titus was Managing Director of Windward Ventures, a
venture capital consulting and investment firm, which he founded in 1993. From May 1986 to December 1992, he served in various capacities at Technology Funding, Inc., a venture
capital firm, including Group Vice President, Technology Funding, Inc., and General Partner of Technology Funding Limited. Prior to joining Technology Funding, Inc. in May 1986,
Mr. Titus was a founder and Senior Vice President of the Technology Division of Silicon Valley Bank. Mr. Titus earned a B.A. in Economics from the University of California, Santa
Barbara. He is a director of several privately held companies.

Nezam Tooloeebecame a director of the Company in April 2000. Mr. Tooloee is an entrepreneur with extensive experience in
both strategy development and start-ups. Until 1989, Mr. Tooloee was a partner with Strategic Decisions Group, specializing in strategic management of technology-intensive
businesses and advising entrepreneurial executives in a wide range of industries. Subsequently, Mr. Tooloee helped found two start-up companies, International Wireless
Communications in 1990 and U.S. AirWaves in 1994, where he was the chief business development officer until 1996. From 1996 to 1998 he served as an advisor to MCI for its wireless strategies prior to
joining ClearComm as the CEO of its U.S. business and a member of its board. Since 1998, he has worked with selected start-ups as a senior advisor. Mr. Tooloee also has ongoing
relationships with SigmaOne Communications, eCommerce Networks, and Magic Bubble, among others. Mr. Tooloee holds degrees in mechanical engineering and management science from Stanford
University.

5

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Loren Israelsenresigned from our Board of Directors on December 28, 2000.

Compliance with Section 16(a) of the Securities Exchange Act of 1934

Section 16(a) of the Securities Exchange Act of 1934, as amended, requires the Company's officers, directors and persons who are the beneficial
owners of more than 10% of the Common Stock to file initial reports of ownership and reports of changes in ownership of the Common Stock with the United States Securities and Exchange Commission
("SEC"). Officers, directors and greater than 10% stockholders are required by SEC regulations to furnish the Company with copies of all Section 16(a) forms they file.

Based
solely on its review of the copies of such forms furnished to the Company and the written representations that no other reports were required, the Company believes that, during
the period from January 1, 2000 to December 31, 2000, all officers, directors and beneficial owners of more than 10% of the Common Stock complied with all
Section 16(a) requirements, except as described herein. Mr. Tooloee did not timely file his Form 3, which untimely filing was subsequently corrected. Each of
Mr. Israelsen and Mr. Titus was late in filing a Form 4, which untimely filing was subsequently corrected. Each of Ms. Conte, Dr. Reaven, Mr. Berg and
Mr. Tooloee was late in filing a Form 5, which untimely filing was subsequently corrected.

Item 11. Executive Compensation

Compensation of Directors

Each non-employee Board member receives an annual retainer fee of $10,000, provided the non-employee Board member attends at least 75%
of the Board meetings. In addition, non-employee Board members are reimbursed for reasonable expenses incurred in connection with their attendance at such meetings. All of the
non-employee Board members did not receive such annual retainer fee in 2000.

Under
the revised Automatic Option Grant Program in effect under the 1992 Plan, a special one-time option grant was made on February 1, 2000 to each individual
serving as a non-employee Board member at that time. The option allowed such non-employee Board member to purchase that number of shares of Common Stock equal to one half of
one percent (0.5%) of the number of voting shares of the Company's capital stock outstanding at that time. Each individual who first joins the Board as a
non-employee Board member will, upon his or her initial appointment or election to the Board, receive a special one-time option grant for number of shares of Common Stock equal
to one half of one percent (0.5%) of the number of voting shares of the Company's capital stock outstanding on February 1, 2000, provided such individual has not previously been in the
Company's employ. Such grant will be lieu of the 1,000-share option grant currently provided under the program for newly-appointed or elected non-employee Board members and the
number of shares subject to such grant will be adjusted for any subsequent changes in the Company's capital structure resulting from stock dividends, stock splits, or other similar transactions. Each
automatic option grant will have a maximum term of 10 years. Each automatic grant will become exercisable for the option shares in a series of 48 successive equal monthly installments over the
optionee's period of continued Board service, measured from the grant date. Prior option grants under the program, all of which have been surrendered, vested in a series of 24 successive equal monthly
installments measured from the applicable grant date. The option would, however, become immediately exercisable for all the option shares upon certain changes in control or ownership of the Company.

Messrs. Israelsen
and Titus, each received, on April 18, 2000, an option grant for 100,000 shares of Common Stock under the 1992 Plan with an exercise price per share of
$0.25. The option grants were surrendered upon issuance of new option grants on June 2, 2000.

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Messrs. Berg, Israelsen, Raab and Tooloee each received, on June 2, 2000, an option grant for 177,808 shares of Common Stock under the 1992 Plan with an exercise price
per share of $0.03. Messrs. Israelsen and Titus, each received, on June 2, 2000, an option grant for 277,804 shares of Common Stock under the 1992 Plan with an exercise price per share
of $0.03. Shares vest over 24 successive months. All prior option grants have been surrendered upon issuance of new option grants on June 2, 2000.

Upon
joining the Board, Mr. Scannell received, on August 7, 2000, an option grant for 151,514 shares of Common Stock under the 1992 Plan with an exercise price per share
of $0.1094. Messrs. Berg, Bellamy, Raab and Israelsen are no longer members of our Board of Directors.

No
other compensation was paid or accrued for directors of the Company with respect to their 2000 services as directors of or consultants to the Company.

Compensation of Executive Officers

The following table sets forth the compensation earned, for services rendered in all capacities to the Company, for each of the last three fiscal years by
(i) the Company's Chief Executive Officer and (ii) the four other highest paid executive officers serving as such at the end of the 2000 fiscal year whose salary and bonus for that
fiscal year was in excess of $100,000. The individuals named in the table will be hereinafter referred to as the "Named Officers." No other executive officer who would otherwise have been included in
such table on the basis of fiscal year 2000 salary and bonus resigned or terminated employment during the year.

SUMMARY COMPENSATION TABLE

|                                                                                                      |  |                |  |                         |           |           |     |       |  | Long-Term Compensation    |           |       | 
|----------------------------------------------------------------------------------------------------- |  | -------------- |  | ----------------------- | --------- | --------- | --- | ----- |  | ------------------------- | --------- | ----- | 
|
|
|
|
|Lisa A. Conte
Director, President, Chief Executive Officer and Chief Financial Officer                |  | 2000
1999
1998 |  | 231,883
287,700
311,537 | (2)(4)(6) | 

3,000 | (7) | 

 |  | 2,003,125
2,489,331
2,045 | (3)(5)(5) | 

 | 
|Steven R. King, Ph.D.
Chief Operating Officer and Senior Vice President, Ethnobotany and Conservation |  | 2000
1999
1998 |  | 179,625
173,872
179,329 |           | 

3,000 | (7) | 

 |  | 2,186,947
775,000
149     | (5)(5)    | 

 | 
|Thomas F. White
Senior Vice President, Commercial Strategy and Chief Sales and Marketing Officer      |  | 2000
1999
1998 |  | 181,387
176,202
       |           | 

     |     | 

 |  | 936,947
533,417
         | (5)       | 

 | 
|Thomas Carlson, M.D.(8)
Vice President, Medical Ethnobotany                                           |  | 2000
1999
1998 |  | 138,301
157,467
157,800 |           | 

3,000 | (7) | 

 |  | 1,201,463
527,000
3       | (5)(5)    | 

 | 

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|John W.S. Chow, Ph.D.
Vice President, Technical Operations |  | 2000
1999
1998 |  | 139,439
166,447
113,807 |  | 

10,000 | (9) | 

 |  | 1,101,875
372,000
65 | (5)(5) | 74,170
77,712
56,281 | (10)(10)(11)
|---------------------------------------------------------- |  | -------------- |  | ----------------------- |  | ---------- | --- | ----- |  | -------------------- | ------ | -------------------- | ------------

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The
following table contains information concerning the grant of stock options under the 1992 and 1999 Stock Option Plans to the Named Officers during the 2000 fiscal year. Except for
the limited stock appreciation right described in footnote (2) below which formed part of the option grant made to each Named Officer, no stock appreciation rights were granted to such Named
Officers during the 2000 fiscal year.

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OPTION/SAR GRANTS IN LAST FISCAL YEAR

|                        |  |                             |           |                 |     |     |                |  |                            | Potential Realizable Value at Assumed Annual Rates of Stock Price Appreciation For Option Term(1) |                     
|----------------------- |  | --------------------------- | --------- | --------------- | --- | --- | -------------- |  | -------------------------- | ------------------------------------------------------------------------------------------------- | --------------------
|
|
|
|Lisa A. Conte           |  | 5,000,000
1,250,000
753,125 | (4)(5)(7) | 18.90
4.73
2.85 | %%% | $$$ | 0.03
0.03
0.01 |  | 06/02/10
06/02/10
12/12/10 |                                                                                                   | 0
121,521
50,004    
|Steven R. King, Ph.D.   |  | 2,000,000
186,947           | (6)(7)    | 7.56
0.71       | %%  | $$  | 0.03
0.01      |  | 06/02/10
12/12/10          |                                                                                                   | 194,433
12,412      
|Thomas F. White         |  | 750,000
186,947             | (6)(7)    | 2.84
0.71       | %%  | $$  | 0.03
0.01      |  | 06/02/10
12/12/10          |                                                                                                   | 72,913
12,412       
|Thomas Carlson, M.D.(8) |  | 1,054,000
147,463           | (6)(5)    | 3.98
0.56       | %%  | $$  | 0.03
0.01      |  | 06/02/10
12/12/10          |                                                                                                   | 102,466
9,791       
|John W.S. Chow, Ph.D.   |  | 744,000
186,000
171,875     | (6)(5)(7) | 2.81
0.70
0.65  | %%% | $$$ | 0.03
0.03
0.01 |  | 06/02/10
06/02/10
12/12/10 |                                                                                                   | 72,329
18,082
11,412

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Option Exercises and Holdings

The following table provides information with respect to the Named Officers concerning the exercise of options during the last fiscal year and unexercised
options held as of the end of the fiscal year (as of December 31, 2000). No stock appreciation rights were exercised during such fiscal year, and except for the limited stock appreciation right
described in Footnote (2) to the Stock Option/SAR Grants Table which forms part of each outstanding stock option, no stock appreciation rights were outstanding at the end of that fiscal year.

AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FY-END OPTION VALUES

|                        |  |   |  | Value Realized
(Market price at
exercise date less
exercise price) ($) |  |           |  |           |  | Value of Unexercised In-the-Money Options at FY-End (Market price of shares at FY-End less exercise price) ($)(1)
|----------------------- |  | - |  | ---------------------------------------------------------------------- |  | --------- |  | --------- |  | -----------------------------------------------------------------------------------------------------------------
|
|
|
|Lisa A. Conte           |  |  |  |                                                                       |  | 2,003,125 |  |          |  | $                                                                                                                
|Steven R. King, Ph.D.   |  |  |  |                                                                       |  | 686,883   |  | 1,500,064 |  | $                                                                                                                
|Thomas F. White         |  |  |  |                                                                       |  | 374,423   |  | 562,524   |  | $                                                                                                                
|Thomas Carlson, M.D.(2) |  |  |  |                                                                       |  | 410,930   |  | 790,533   |  | $                                                                                                                
|John W.S. Chow, Ph.D.   |  |  |  |                                                                       |  | 543,851   |  | 558,024   |  | $                                                                                                                

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Option Repricings

On June 2, 2000, the Company implemented a special option cancellation/regrant program for all of its employees and non-employee Board
members. Each individual was given the opportunity to surrender his or her existing options under the 1999 Plan in return for a new option grant with an exercise price of $0.03 per share. Each of the
Named Officers participated in the option cancellation/regrant program. Options for a total of 4,696,748 shares with an exercise price of $0.34 for the Named Officers were surrendered for cancellation
and new options for a total of 10,984,000 shares with an exercise price of $0.03 per share were granted.

Employment Contracts, Termination Agreements and Change of Control Agreements

On March 15, 1999, the Board of Directors approved a Change in Control provision concerning severance benefits for key executives. Pursuant to the
provision, should their employment with the Company terminate within 12 months after a Change in Control, for any reason other than for cause, they will be entitled to receive in one lump sum
payment the cash equivalent of 12 months of base salary plus any benefits to which they would otherwise be entitled. In connection with these severance

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benefits, the Company has agreed to pay the premiums for any COBRA coverage to which these individuals or their spouse or dependents are entitled under a Company sponsored medical plan after a Change
in Control. In addition, in the event of a Change in Control, all of the options held by such key executives will automatically become fully vested and exercisable. Such executives' exercisable shares
will be fixed at the termination of their employment, and they will have a period of 90 days from their termination date to purchase such exercisable shares, as set forth in the stock option
agreements applicable to their options.

On
March 30, 1998, the Company entered into a letter agreement with John W.S. Chow, Ph.D., pursuant to which he served as Vice President, Technical Operations. Pursuant to the
letter agreement, Dr. Chow is paid an annual salary of $165,000 in addition to the sign-on bonus paid to him in the amount of $10,000, and he was reimbursed for closing costs
incurred in the sale of his former residence in New Jersey and the purchase of his new residence in the Bay Area. Dr. Chow was also granted an option for 50 shares of Common Stock on
May 15, 1998 with an exercise price per share of $4,937.50,
the fair market value per share of Common Stock on that date. Dr. Chow was also granted an additional 15 shares of Common Stock on May 15, 1998 with an exercise price of $4,937.50, the
fair market value per share of Common Stock on that date. Dr. Chow surrendered these options upon granting the Series R Preferred Stock option on December 14, 1999. The Company
further agreed to pay Dr. Chow's reasonable moving expenses in an amount not to exceed $20,000 and to provide him with an apartment for up to four months at a rental not to exceed $2,500
per month. Should the Company terminate Dr. Chow's employment for any reason other than for cause prior to May 1, 2001, the Company will continue to pay Dr. Chow's base salary
plus benefits on a monthly basis for up to six months or until Dr. Chow obtains near full-time employment or consulting of at least 80% of his time, whichever occurs sooner. The
Company also extended a $300,000 loan to Dr. Chow in connection with his purchase of a new residence in the Bay Area. See "Certain Relationships and Related Transactions."

None
of the Company's other executive officers have employment agreements with the Company, and their employment may be terminated at any time at the discretion of the Board of
Directors. As administrator of the Plan, the Compensation Committee has the authority to provide for accelerated vesting of the shares of Common Stock subject to any outstanding options held by the
Chief Executive Officer and the Company's other executive officers or any unvested shares actually held by those individuals under the Plan upon a change in control of the Company effected through a
successful tender offer for more than 50% of the Company's outstanding voting securities or through a change in the majority of the Board as a result of one or more contested elections for Board
membership.

Compensation Committee Interlocks and Insider Participation

During the 2000 fiscal year, Herbert H. McDade and Adrian D.P. Bellamy, who were then members of the Board of Directors, served as members of the Compensation
Committee of the Board of Directors. No member of the Compensation Committee was, at any time during the 2000 fiscal year or at any earlier time, an officer or employee of the Company.
Messrs. McDade and Bellamy resigned from the Board and the Compensation Committee in April 2000 and July 2000, respectively. No replacements were named.

No
executive officer of the Company serves as a member of the board of directors or compensation committee of any entity which has one or more executive officers serving as a member
of the Company's Board of Directors or Compensation Committee.

Item 12. Security Ownership of Certain Beneficial Owners and Management

The following table sets forth certain information known to the Company with respect to the beneficial ownership of the Common Stock as of April 23,
2001 by (i) all persons who are beneficial

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owners of five percent or more of the Common Stock, (ii) each director, (iii) the Named Officers in the Summary Compensation Table above and (iv) all current directors and
executive officers as a group. The number of shares beneficially owned by each director or executive officer is determined under rules of the SEC and the information is not necessarily indicative of
beneficial ownership for any other purpose. Shares of Common Stock subject to options or warrants currently exercisable or exercisable within 60 days of April 23, 2001 are deemed to be
beneficially owned by the person holding such option or warrant for computing the percentage ownership of such person, but are not treated as outstanding for computing the percentage of any other
person. Except as otherwise indicated, the Company believes that the beneficial owners of the Common Stock listed below, based upon such information furnished by such owners, have sole investment
power with respect to such shares, subject to community property laws where applicable.

|                                                                                                                                       |  | Shares of Common
Stock Owned |     
|-------------------------------------------------------------------------------------------------------------------------------------- |  | ---------------------------- | ----
|
|Tradewinds Debt Strategies Fund, L.P.(6)(8)
c/o Tradewinds Financial Corporation
591 Redwood Highway, Suite 2355
Mill Valley, CA 94941 |  | 8,664,521                    | (3) 
|Vulcan Ventures, Inc
505 Union Station
505 Fifth Avenue South, Suite 900
Seattle, WA 98104                                             |  | 8,676,476                    | (4) 
|Selima International S.A.
Via Espana 2000
Panama                                                                                       |  | 6,985,870                    | (5) 
|Scott P. Peters(6)
c/o Tradewinds Financial Corporation
591 Redwood Highway, Suite 2355
Mill Valley, CA 94941                          |  | 9,413,699                    | (7) 
|Robert R. Scannell(8)                                                                                                                  |  | 9,485,284                    | (9) 
|Lisa A. Conte                                                                                                                          |  | 2,094,014                    | (10)
|Thomas Carlson, M.D.(11)                                                                                                               |  | 555,085                      | (12)
|John W.S. Chow                                                                                                                         |  | 750,536                      | (13)
|Steven R. King, Ph.D.                                                                                                                  |  | 1,202,404                    | (14)
|Gerald R. Reaven, M.D.                                                                                                                 |  | 218,560                      | (15)
|Thomas F. White                                                                                                                        |  | 565,032                      | (16)
|M. David Titus                                                                                                                         |  | 322,979                      | (17)
|Nezam Tooloee                                                                                                                          |  | 281,132                      | (18)
|Directors and officers as a group                                                                                                      |  | 15,475,025                   | (19)

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Item 13. Certain Relationships and Related Transactions

On June 17, 1998, the Company loaned $300,000 to John W.S. Chow, Ph.D., the Vice President, Technical Operations, to reimburse him for a reasonable
difference between the purchase price of his residence in the Bay Area and the cost of comparable housing in New Jersey, his former state of residence. The loan is evidenced by his promissory note of
the same date which will become due and payable in a series of five successive equal annual installments, with the first such installment due on June 25, 1999. The note will bear interest at a
variable per annum rate equal to the short-term applicable federal rate in effect under the federal tax laws for January of each calendar year the loan remains outstanding.
Accordingly, the interest rate in effect for the period Dr. Chow's note was outstanding during the 1998 calendar year was 5.52%. Accrued and unpaid interest will become due and payable each
year on the same date the principal installment for that year becomes payable. Each installment of principal and accrued interest will automatically be forgiven as that installment becomes due,
provided Dr. Chow continues in the Company's employ. However, the entire unpaid balance of the note, together with all accrued and unpaid interest, will become immediately due and payable upon
Dr. Chow's termination of employment with the Company prior to June 25, 2003, unless Dr. Chow's employment is involuntarily terminated by the Company other than for cause. In the
event (i) the Company terminates Dr. Chow's employment for any reason other than for cause or (ii) Dr. Chow's employment terminates by reason of his death or disability,
then the entire principal balance of the note plus accrued interest will be forgiven. The Company is currently renegotiating the terms of Dr. Chow's employment agreement.

On
February 28, 2001, Shaman borrowed $188,000 from Anthony Conte, father of Lisa Conte, our President and Chief Executive. The note bears interest at the annual rate of 10%
per annum and is due and payable on or before April 1, 2001. The note is secured by Shaman's SP-303 and Diabetes intellectual properties. The note was re-paid in April
2001.

Indemnification Agreements

Shaman's Certificate of Incorporation limits, to the maximum extent permitted by Delaware Law, the personal liability of directors for monetary damages for
breach of their fiduciary duties as a director. Our Bylaws provide that we will indemnify our officers, directors, employees and agents to the full extent permitted by the general corporation law of
Delaware. We have entered into indemnification agreements with our officers and directors containing provisions which are in some respects broader than the specific indemnification provisions
contained in Delaware Law. The indemnification
agreements may require us, among other things, to indemnify such officers and directors against certain liabilities that may arise by reason of their status or service as directors or officers (other
than liabilities arising from willful misconduct of a culpable nature), to advance their expenses incurred as a result of any proceeding against them as to which they could be indemnified, and to
obtain directors' and

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officers' insurance, if available on reasonable terms. We currently maintain directors' and officers' insurance.

Section 145
of the Delaware Law provides that a corporation may indemnify a director, officer, employee or agent made or threatened to be made a party to an action by reason of
the fact that he was a director, officer, employee or agent of the corporation or was serving at the request of the corporation against expenses actually and reasonably incurred in connection with
such action if he acted in good faith and in a manner he reasonably believed to be in or not opposed to the best interests of the corporation, and, with respect to any criminal action or proceeding,
had no reasonable cause to believe his conduct was unlawful. Delaware Law does not permit a corporation to eliminate a director's duty of care, and the provisions of our Certificate of Incorporation
have no effect on the availability of equitable remedies, such as injunction or rescission, for a director's breach of the duty of care.

Item 14. Exhibits, Financial Statement Schedules and Reports on Form 8-K

Exhibit Number

Description23.1

Consent of BDO Seidman LLP, Independent Auditors.


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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be
signed on its behalf by the undersigned, thereunto duly authorized.

|Dated: April 27, 2001 |  | SHAMAN PHARMACEUTICALS, INC.
|--------------------- |  | ----------------------------
|                      |  | By:                         

IN
WITNESS WHEREOF, each of the undersigned has executed this Power of Attorney as of the date indicated.

Pursuant
to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and
on the dates indicated.

|Signature                                |  | Title                                                                                                                |  | Date          
|---------------------------------------- |  | -------------------------------------------------------------------------------------------------------------------- |  | --------------
|                                         |  |                                                                                                                      |  |               
|/s/LISA A. CONTELisa A. Conte            |  | President, Chief Executive Officer, Chief Financial Officer and Director (principal executive and financial officer) |  | April 27, 2001
|/s/ROBERT W. SCANNELL*Robert W. Scannell |  | Director                                                                                                             |  | April 27, 2001
|/s/M. DAVID TITUS*M. David Titus         |  | Director                                                                                                             |  | April 27, 2001
|/s/NEZAM TOOLOEE*Nezam Tooloee           |  | Director                                                                                                             |  | April 27, 2001

|* By: |  | /s/LISA A. CONTELisa A. Conte,Attorney-in-Fact |  |  |  | April 27, 2001
|----- |  | ---------------------------------------------- |  |  |  | --------------

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