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          About NIAMS
          Shamima Islam, M.B.B.S., Ph.D.





Shamima Islam, M.B.B.S., Ph.D.


Biologist
    Genomic Technology Section
    Office of Science and Technology Image
              Photo of Shamima Islam 
            Contact Information

                                
                                                9000 Rockville Pike
                  
                  
            Building 50, Room 1507
      
                                   Bethesda MD 20892
                
                                                shamima.islam@nih.gov 
                Summary
          Shamima Islam, M.B.B.S., Ph.D., conducts basic and translational investigations in the field of immunology. She uses interdisciplinary approaches that combine and integrate molecular, cellular, and immunological levels of analysis. Her academic credentials include a Ph.D. in Microbiology and Immunology and a Bachelor’s in Medicine. Dr. Islam has designed, led, and managed projects to develop novel therapeutics for diseases such as arthritis, primary immune deficiency disease, and acute lung injury.

During her research tenure, she mentored graduate students and visiting scholars to help them understand scientific methodologies in molecular biology, immunology, and cell biology experiments with a contemporary approach to science. Dr. Islam built cross-functional collaborative relationships within the institution and with external scientific and medical communities. She understands the value of integrated research and translating the knowledge from the bench to the bedside. She is willing and able to learn, grow, and adapt to a new workplace environment and positively impact the organization’s goal.

Major areas of research:

Cellular signaling.
	Vaccine study.
	Diseases: Primary immunodeficiency diseases (X-Linked Agammaglobulinemia), arthritis, acute lung injury.
	Drug development and gene therapy. 

            Scientific Publications
              Epigenetic regulation of NfatC1 transcription and osteoclastogenesis by nicotinamide phosphoribosyl transferase in the pathogenesis of arthritis.

    Li X, Islam S, Xiong M, Nsumu NN, Lee MW Jr, Zhang LQ, Ueki Y, Heruth DP, Lei G, Ye SQ
        

                    Cell Death Discov.
        
                    2019;
        
                    5().
        
                    doi: 10.1038/s41420-018-0134-6
                            PMID: 30774990
  Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown.

    Bi G, Wu L, Huang P, Islam S, Heruth DP, Zhang LQ, Li DY, Sampath V, Huang W, Simon BA, Easley RB, Ye SQ
        

                    FASEB J.
        
                    2018 Jul;
        
                    32(7).
        
                    doi: 10.1096/fj.201701059R
                            PMID: 29452569
  CCR7/CCL19 controls expression of EDG-1 in T cells.

    Shannon LA, McBurney TM, Wells MA, Roth ME, Calloway PA, Bill CA, Islam S, Vines CM
        

                    J Biol Chem.
        
                    2012 Apr 6;
        
                    287(15).
        
                    doi: 10.1074/jbc.M111.310045
                            PMID: 22334704
  Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax.

    Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E
        

                    Proc Natl Acad Sci U S A.
        
                    2010 Jun 8;
        
                    107(23).
        
                    doi: 10.1073/pnas.1002348107
                            PMID: 20479237
  Involvement of interleukin-1 receptor-associated kinase (IRAK)-M in toll-like receptor (TLR) 7-mediated tolerance in RAW 264.7 macrophage-like cells.

    Hassan F, Islam S, Tumurkhuu G, Dagvadorj J, Naiki Y, Komatsu T, Koide N, Yoshida T, Yokochi T
        

                    Cell Immunol.
        
                    2009;
        
                    256(1-2).
        
                    doi: 10.1016/j.cellimm.2009.01.013
                            PMID: 19251253
  Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cells.

    Islam S, Hassan F, Tumurkhuu G, Dagvadorj J, Koide N, Naiki Y, Mori I, Yoshida T, Yokochi T
        

                    Biochem Biophys Res Commun.
        
                    2007 Aug 24;
        
                    360(2). 
          Education
              
            **Aichi Medical University School of Medicine, Japan**
Ph.D., Microbiology and Immunology

**Khulna Medical College, Bangladesh**
Bachelor of Medicine and Bachelor of Surgery (M.B.B.S.)             
                        Experience
              
            **Postdoctoral Fellowship**
Children’s Mercy Hospital, Missouri

**Postdoctoral Fellowship**
University of Kansas Medical Center, Kansas

**Postdoctoral Fellowship**
NIAID/NIH, Maryland


Last Updated: June 2023


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