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        DP3
                K Awards
                P30
                P50
                RC2
                R13
                R15
                R21
                R41/R42
                R43/R44
                T32
                T35
                TL1
                U01: Research Project Cooperative Agreement
                U34: Implementation Planning Cooperative Agreement
                U54: Specialized Center Cooperative Agreements
                Supplements to Research Grants
                NIDDK Collaborative Grants Comparison
                New & Early Stage InvestigatorsAbout Funding Mechanisms
    NIH uses several types of grants to support research projects. Each has special characteristics, uses, and
guidelines. NIDDK supports the NIH funding mechanisms mentioned below. For some awards, however,
the links below provide guidance about specific NIDDK support.
If you think you may qualify as a New Investigator or an Early Stage Investigator, review the New and Early
Stage Investigator page.
Expand All
    Research Project - R01, RC2, etc.
View the collaborative grants comparison table to learn about the difference among a P01, RC2, and R01.    
        R01 Research Project Grant
                    Support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his specific interest and competencies.

                        General NIH information about the R01
                R13 Research Conference Grant
                    Supports recipient sponsored and directed international, national, or regional meetings, conferences, and workshops.

                        NIDDK-specific information about the R13
                R15 Academic Research Enhancement Award (AREA)
                    Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation’s research scientists that have not been major recipients of NIH support.

                        NIDDK-specific information about the R15
                R16 Research Excellence Award
                    Supports small-scale research projects at educational institutions that that enroll significant numbers of students from backgrounds nationally underrepresented in biomedical research, award baccalaureate and graduate degrees in biomedical sciences, and receive limited NIH funding.

                        General NIH information about the R16
                R18 Research Demonstration and Dissemination Project
                    Provides support designed to develop, test, and evaluate health service activities, and to foster the application of existing knowledge for the control of categorical diseases.

                        General NIH information about the R18
                R21 Exploratory/Developmental Grant
                    Supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his specific interest and competencies.
                    

                        NIDDK-specific information about the R21
                R24 Resource-Related Research Project
                    Supports research projects that will enhance the capability of resources to serve biomedical research.

                        General NIH information about the R24
                R25 Education Projects
                    Support to develop and/or implement a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation.

                        General NIH information about the R25
                R34 Clinical Trial Planning Grant
                    Supports the initial development of a clinical trial, including the establishment of the research team; the development of tools for data management and oversight; the development of a trial design and other essential elements of the study; and the  collection of feasibility data.

                        General NIH information about the R34
                RC2 High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2)
                    Supports high impact ideas that may lay the foundation for new fields of investigation; accelerate breakthroughs; stimulate early and applied research on cutting-edge technologies; foster new approaches to improve the interactions among multi- and interdisciplinary research teams; or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery.

                        NIDDK-specific information about the RC2
                P01 Program Project Grant
                    Supports a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme.

                        General NIH information about the P01
                DP1 NIH Director’s Pioneer Award
                    Supports individual scientists of exceptional creativity, who propose pioneering – and possibly transforming approaches – to major challenges in biomedical and behavioral research.

                        General NIH information about the DP1
                DP2 NIH Director’s New Innovator Award
                    Supports highly innovative research projects by new investigators in all areas of biomedical and behavioral research.

                        General NIH information about the DP2
                DP3 Type 1 Diabetes Targeted Research Award
                    Supports research tackling major challenges in type 1 diabetes and promotes new approaches to these challenges by scientific teams.

                        NIDDK-specific information about the DP3
                DP5 Early Independence Award
                    Supports the independent research project of a recent doctoral degree recipient.

                        General NIH information about the DP5
                S06 Native American Research Centers for Health (NARCH)
                    Supports partnerships between American Indian/Alaska Native (AI/AN) tribes or tribally-based organizations and institutions that conduct intensive academic-level biomedical, behavioral and health services research.

                        General NIH information about the S06
                SC1 Research Enhancement Award
                    Supports individual investigator-initiated research projects aimed at developing researchers at minority-serving institutions to a stage where they can transition successfully to other extramural support (R01 or equivalent).

                        General NIH information about the SC1
                SC2 Pilot Research Project
                    Supports individual investigator-initiated pilot research projects for faculty at minority-serving institutions to generate preliminary data for a more ambitious research project.

                        General NIH information about the SC2
                SC3 Research Continuance Award
                    Individual investigator-initiated research projects for faculty at MSIs to conduct research of limited scope in environments with limited research infrastructure/facilities.

                        General NIH information about the SC3
                U01 Research Project Cooperative Agreement
                    Supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his specific interest and competencies.

                        NIDDK-specific information about the U01
                U13 Research Conference Cooperative Agreement
                    Supports international, national, or regional meetings, conferences, and workshops where substantial programmatic involvement is planned to assist the recipient.

                        General NIH information about the U13
                U34 Multi-Center Clinical Study Cooperative Agreement
                    Supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his specific interest and competencies.
                    

                        NIDDK-specific information about the U34
                UC4 High Impact Research and Research Infrastructure Cooperative Agreement Programs—Multi-Yr Funding
                    Supports multi-year funded cooperative agreement research with high impact ideas that may lay the foundation for new fields of investigation; accelerate breakthroughs; stimulate early and applied research on cutting-edge technologies; foster new approaches to improve the interactions among multi- and interdisciplinary research teams; or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery.

                        General NIH information about the UC4
                X01 Resource Access Program
                    Invites eligible institutions to seek access to NIH research resources. This includes programs where institutions will request access to submit to the resource. It also includes programs where access to a NIH research resource is needed to conduct research.

                        General NIH information about the X01
                X02 Preapplication
                    A program to invite eligible institutions to submit a pre-application (also known as a "white paper" or "précis") to facilitate certain approaches or economies, such as reducing burden on the applicant community, for a funding opportunity

                        General NIH information about the X02Small Business - R41, R42, R43, R44
R41/R42 Small Business Technology Transfer Grant (STTR)
                    Supports cooperative R&D projects between small business concerns and research institutions to establish the technical merit and feasibility of ideas that have potential for commercialization. Awards are made to small business concerns only.

                        NIDDK-specific information about the R41/R42
                R43/R44 Small Business Innovation Research Grant (SBIR)
                    Supports projects to establish the technical merit and feasibility of R&D ideas which may ultimately lead to a commercial product(s) or service(s).

                        NIDDK-specific information about the R43/R44
                SB1 Commercialization Readiness Program (CRP)
                    To support follow-on awards to small businesses for technology development, testing, evaluation, and commercialization assistance for SBIR or STTR Phase II technologies or for awards to small businesses to support the progress of research, research and development, and commercialization conducted under the SBIR or STTR programs to Phase III.

                        General NIH information about the SB1Training and Career Development - F, K, T, and Loan Repayment, etc.
F30 Individual Predoctoral National Research Service Award (NRSA) for M.D./Ph.D. Fellowship
                    Support for students enrolled in M.D./Ph.D., or equivalent, combined degree programs once they have identified a dissertation project.

                        General NIH information about the F30
                F31 Diversity Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research
                    Supports the research training of predoctoral students from population groups that have been shown to be underrepresented in the biomedical, behavioral, or clinical research workforce.
                    

                        General NIH information about the F31 Diversity
                F31 Individual Predoctoral National Research Service Award (NRSA)
                    Support for students enrolled in a doctoral degree program (usually Ph.D.) once they have identified a mentor and have chosen a dissertation research project.

                        General NIH information about the F31
                F32 Individual Postdoctoral National Research Service Award (NRSA)
                    Supports postdoctoral fellows to pursue mentored research training prior to applying for a faculty position.

                        General NIH information about the F32
                F99/K00 Pre-doc to Post-doc Transition Award
                    To support the Pre-doctoral Phase of a Pre-doctoral to Post-doctoral transition award that provides 1-2 years of predoctoral support for highly motivated graduate students. The F99 activity code is intended to only be used in conjunction with a K00 Award

                        General NIH information about the F99/K00
                K01 Research Scientist Development Award
                    Supports basic scientists (non-clinicians) as they transition to independence and develop their careers with the support of a mentor.

                        NIDDK-specific information about the K01
                K08 Clinical Investigator Award
                    Supports early clinician scientists who are transitioning to independence in a junior faculty position while pursuing a basic or clinical research project and developing their career.

                        NIDDK-specific information about the K08
                K12 Clinical Scientist Institutional Career Development Award
                    Award to an institution to support several individuals as they transition from fellowship to faculty while pursuing a research project with the help of a mentor(s).

                        NIDDK-specific information about the K12
                K23 Mentored Patient-Oriented Research Career Development Award
                    Supports the career development of investigators who have made a commitment to focus their research endeavors on patient-oriented research. Supports early clinician scientists who are transitioning to independence in a junior faculty position and developing their career while pursuing a clinical research project that involves direct patient contact and the support of a mentor(s).

                        NIDDK-specific information about the K23
                K25 Mentored Quantitative Research Career Development Award
                    Supports highly productive postdoctoral fellows pursuing  mentored research projects while looking for faculty appointments.

                        NIDDK-specific information about the K25
                K99/R00 Pathway to Independence Award
                    Supports the initial phase of a Career/Research Transition award program that provides 1-2 years of mentored support for highly motivated, advanced postdoctoral research scientists.

                        NIDDK-specific information about the K99/R00
                L30 Loan Repayment Program for Clinical Researchers
                    NIH may repay up to $35,000 of your qualified student loan debt per year, including most undergraduate, graduate, and medical school loans if you are actively engaged in clinical research.

                        General NIH information about the L30
                L40 Loan Repayment Program for Pediatric Researchers
                    NIH may repay up to $35,000 of your qualified student loan debt per year, including most undergraduate, graduate, and medical school loans if you are actively engaged in research related to a pediatric disease or disease model.

                        General NIH information about the L40
                L60 Loan Repayment Program for Health Disparities Research
                    

                        General NIH information about the L60
                L70 Loan Repayment Program for Research in Emerging Areas Critical to Human Health
                    

                        General NIH information about the L70
                R03 Small Research Grant Program
                    Supports research projects that can be completed in a 2-yr time frame. NIDDK does not participate in the parent NOFO for R03s, but issues NOFOs for specific audiences, e.g. NIDDK- supported K01, K08, and K23 awardees.

                        General NIH information about the R03
                R16 Research Excellence Award
                    Supports small-scale research projects at educational institutions that that enroll significant numbers of students from backgrounds nationally underrepresented in biomedical research, award baccalaureate and graduate degrees in biomedical sciences, and receive limited NIH funding.

                        General NIH information about the R16
                R25 Education Projects
                    Support to develop and/or implement a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation.

                        General NIH information about the R25
                S06 Native American Research Centers for Health (NARCH)
                    Supports partnerships between American Indian/Alaska Native (AI/AN) tribes or tribally-based organizations and institutions that conduct intensive academic-level biomedical, behavioral and health services research.

                        General NIH information about the S06
                SC3 Research Continuance Award
                    Individual investigator-initiated research projects for faculty at MSIs to conduct research of limited scope in environments with limited research infrastructure/facilities.

                        General NIH information about the SC3
                T32 Institutional National Research Service Award (NRSA)
                    Award to an institution to support several individuals, selected by the institution, in either short-term, predoctoral, and/or postdoctoral training positions with experienced mentors.

                        NIDDK-specific information about the T32
                T32 Medical Student Research Training Supplement
                    Additional slot awarded to an existing training grant for either a specific medical student wishing to take a year off from school to pursue research training or for a pre- or post-doctoral trainee from a group underrepresented in biomedical research, when no slot is available on the training grant.

                        NIDDK-specific information about the T32
                T35 Short-Term National Research Service Award (NRSA)
                    Provides 2-3 months of support for medical students, selected by the institution, to pursue research training during off-quarters or summer periods.

                        NIDDK-specific information about the T35
                TL1 Linked Training Award
                    The TL1 supports research training experiences for pre-doctoral and post-doctoral trainees who are appointed as part of the KUH Institutional Network Award.

                        NIDDK-specific information about the TL1
                U24 Resource - Related Research Projects- Cooperative Agreement
                    To support research projects contributing to improvement of the capability of resources to serve biomedical research.

                        General NIH information about the U24
                X02 Preapplication
                    A program to invite eligible institutions to submit a pre-application (also known as a "white paper" or "précis") to facilitate certain approaches or economies, such as reducing burden on the applicant community, for a funding opportunity

                        General NIH information about the X02Centers - P20, P30, etc.
P20 Center Exploratory Grant
                    Supports planning for new programs, modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of significance to the NIH.

                        General NIH information about the P20
                P30 Center Core Grant
                    Supports shared resources and facilities for categorical research by a number of investigators who provide a multidisciplinary approach to a joint research effort.

                        NIDDK-specific information about the P30
                P50 Specialized Center Grant
                    

                        NIDDK-specific information about the P50
                S06 Native American Research Centers for Health (NARCH)
                    Supports partnerships between American Indian/Alaska Native (AI/AN) tribes or tribally-based organizations and institutions that conduct intensive academic-level biomedical, behavioral and health services research.

                        General NIH information about the S06
                U24 Resource - Related Research Projects- Cooperative Agreement
                    To support research projects contributing to improvement of the capability of resources to serve biomedical research.

                        General NIH information about the U24
                U54 Specialized Center Cooperative Agreement
                    Supports any part of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort.

                        NIDDK-specific information about the U54
                UH2/UH3 Exploratory/Developmental Cooperative Agreement Phase I and II
                    To support the development of new research activities (UH2) and potentially expand on these activities during a second phase (UH3).

                        General NIH information about the UH2/UH3
                X01 Resource Access Program
                    Invites eligible institutions to seek access to NIH research resources. This includes programs where institutions will request access to submit to the resource. It also includes programs where access to a NIH research resource is needed to conduct research.

                        General NIH information about the X01
        Last Reviewed November 2023 Contact Us
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