MANUFACTURING/SUPPLY AGREEMENT


           This Agreement made and entered into this 25th day of August, 1992,
by and between GENETIC LABORATORIES WOUND CARE, INC. (hereinafter "GLWC") and
TAPEMARK COMPANY, (hereinafter "TAPEMARK").

                                   WITNESSETH:
           WHEREAS, TAPEMARK has the ability to produce certain products or
           their components, (hereinafter "PRODUCT"); and WHEREAS, GLWC and
           TAPEMARK wish TAPEMARK to manufacture the PRODUCT for GLWC; NOW,
           THEREFORE, in consideration of the mutual covenants herein contained,
           GLWC and TAPEMARK agree as follows:

Section 1 - Term and Termination of Agreement
1.1        This Agreement shall be in effect from the date on signing through
           and concluding August 25, 1999. It shall thereafter be renewable for
           successive terms of three years each.

1.2        The Agreement may be terminated in the event TAPEMARK fails to
           provide PRODUCT according to specifications, or does not meet agreed
           upon completion dates noted on the Production Orders. In such event,
           GLWC shall first give TAPEMARK written notice of any default and
           allow a period of thirty (30) days for corrective action. If, after
           such notice and elapse of time, TAPEMARK is unwilling or unable to
           correct the default, GLWC may terminate this Agreement unilaterally,
           without further notice.

1.3        This Agreement may also be terminated by either party upon ninety
           (90) days notice without any fault on the part of the other party.

Section 2 - Manufacturing

2.1        TAPEMARK shall supply PRODUCT in accordance with specifications
           provided by GLWC.

2.2        Any and all changes to the specifications by TAPEMARK need prior
           notification and authorization by GLWC.

Section 3 - Pricing and Payments

3.1        All prices shall be completed and mutually agreed to in advance of
           any manufacturing commencement by TAPEMARK. 3.2 Terms of payment will
           be net thirty (30) days from date of receipt of shipment F.O.B. West
           Saint Paul, Minnesota.

Section 4 - Equipment

4.1        TAPEMARK agrees to maintain and operate all equipment in compliance
           with all applicable federal and state safety regulations.

4.2        TAPEMARK will be responsible for providing its own employees training
           in the safe and proper operation of any equipment supplied by GLWC.


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Section 5 - Material Usage and Storage

5.1        TAPEMARK shall inspect and approve raw materials on the basis of
           criteria provided by GLWC and will not be responsible for
           defects in said material.

5.2        TAPEMARK agrees to handle and dispose of all material in accordance
           with all applicable federal and state regulations.

Section 6 - Quality

6.1        TAPEMARK agrees to manufacture PRODUCT in accordance with mutually
           agreed specifications and CGMP's outlined by the U.S. FDA and DOH.

6.2        GLWC shall have the right to reject PRODUCT that does not meet its
           specifications.

6.3        Any rejection of Product shall be in writing and shall specify the
           non-compliance.

6.4        TAPEMARK shall allow representatives of GLWC to inspect the
           manufacturing site as needed pursuant to GLWC auditing procedures.
           GLWC shall provide TAPEMARK with as much advance notification as
           possible prior to such inspections. However, it shall have the right
           of inspection at any time during normal business hours. In addition,
           GLWC shall have the right to inspect the raw material vendors'
           manufacturing facilities upon the same conditions. Consummation of
           this Agreement shall be subject to a satisfactory preliminary
           inspection by GLWC personnel of any manufacturing facility at which
           PRODUCT or raw material is to be produced.

6.5        TAPEMARK shall obtain an Establishment Registration Number from FDA,
           maintain traceability records on the PRODUCT manufactured, and
           cooperate at its expense with GLWC in the event GLWC shall ever
           initiate any remedial action for the PRODUCT covered by this
           Agreement. TAPEMARK shall notify GLWC promptly in writing in the
           event a governmental agency issues an inspection report or other
           finding of non-compliance in connection with PRODUCT, its
           manufacture, storage of handling and shall provide GLWC with a copy
           of any such report or finding, edited for data or information not
           related to GLWC or PRODUCT. GLWC shall have the right to participate
           with TAPEMARK in the preparation of any response to said finding of
           non-compliance. GLWC shall be responsible for creating and printing
           all warnings, precautions, and PRODUCT labels required for the
           PRODUCT, although TAPEMARK shall assist GLWC in the preparation of
           these materials as requested.
6.6        With respect to product liability, each party shall be independently
           responsible for its acts and omissions and shall indemnify and hold
           the other party harmless for liability caused by its own acts or
           omissions.

Section 7 - Confidential Information

7.1        TAPEMARK shall not grant access to any current or potential customers
           to the immediate area and equipment where GLWC products are being
           manufactured without prior approval of GLWC. The manufacturing
           area(s) will be partitioned off to limit access when other customers
           or customer representatives are present in the manufacturing
           facility.
7.2        All information designated as confidential and exchanged between GLWC
           and TAPEMARK while this Agreement is in effect shall be treated as
           confidential and neither party shall, for a period of three (3) years
           after termination of this Agreement or any renewal thereof (or such
           longer period as may be specified in writing) exchange or disclose
           such information to any third party without the prior written
           approval of GLWC.

Section 8 - Responsibilities of GLWC - It shall be the responsibility of GLWC
hereunder to:

8.1        Issue purchase orders for all PRODUCT to be manufactured at TAPEMARK.

8.2        If GLWC changes the production schedule and interrupts an order in
           process, GLWC will advise TAPEMARK either to: A. Transfer the balance
           to another order.
           B.    Hold interrupted order open until further notification.

Section 9 - Notice

9.1        Any notices in correspondence given hereunder shall be in writing
           directed to the addresses specified below and effective upon receipt
           when delivered by hand or posted as first class Certified Mail,
           Return Receipt Requested.

           9.1.1 If intended for TAPEMARK;
                     TAPEMARK Company
                     150 East Marie Avenue
                     West St. Paul, MN 55118
                     Attention:  President

           9.1.2 If intended for GLWC:

                     Genetic Laboratories Wound Care, Inc.
                     2726 Patton Road
                     St. Paul, MN 55113
                     Attention:  President


Section 10 - Production Planning and Scheduling

10.1       GLWC shall provide TAPEMARK with a rolling six (6) month estimate of
           product requirements for production planning and material purchases.
           GLWC orders will be issued to TAPEMARK to cover a minimum two (2)
           months time frame. Requirements established for month one (1) will be
           considered fixed. GLWC shall have the ability to make revisions to
           Production Orders issued for month two (2).

10.2       GLWC shall review production requirements with TAPEMARK at regular
           monthly intervals.

Section 11 - General

11.1       The relationship between GLWC and TAPEMARK is intended to be that of
           buyer and seller. TAPEMARK and its employees, agents, and
           representatives shall under no circumstances be considered agents,
           partners, joint venturers, or representatives of GLWC. TAPEMARK shall
           not act or attempt to act, or represent itself, directly or be
           implication, as agent, joint venturer, or representative of GLWC or
           in any manner assume or attempt to assume or create any obligation or
           liability of any kind, nature, or sort expressed or implied on behalf
           of or in the name of GLWC.

11.2       This Agreement and the exhibits attached hereto contain the entire
           understanding of the parties, It shall superseded any other oral or
           written agreements and shall be binding upon and inure to the benefit
           of the respective parties, their successors and permitted assigns.

11.3       This agreement shall not be modified in any way without written
           consent of both parties, and neither party shall have the right to
           assign this Agreement, in whole or in part, without the prior written
           consent of the other, which consent shall not be unreasonably
           withheld provided, however, that GLWC may assign this Agreement to a
           purchaser or successor of GLWC entire business related to this
           subject matter.

11.4       This Agreement shall be construed in accordance with laws of the
           State of Minnesota.

11.5       The obligations of either party to perform under this Agreement shall
           be excused if such failure to perform or any delay is caused by
           matters such as acts of god, strikes, civil commotion, riots, wars,
           revolution, acts of government, or any other cause whether similar or
           dissimilar to those enumerated which is reasonably beyond the control
           of the party obligated to perform. Upon the occurrence of such event,
           the duties and obligations of the parties shall be suspended for the
           duration of the event preventing proper performance under this
           Agreement; provided, however, that if such suspension shall continue
           in excess of ninety (90) days, the parties shall attempt to arrive at
           a mutually acceptable compromise within the spirit and intent of this
           Agreement.

11.6       If any provision of this Agreement is held to be void or illegal, the
           rest of the Agreement shall be deemed binding upon the parties
           hereto.

           IN WITNESS WHEREOF, the parties hereto have by their duly authorized
           officers, executed this Agreement as of the day and year first
           written above.

GENETIC LABORATORIES WOUND                TAPEMARK COMPANY
  CARE, INC.



By _____________________________              By _____________________________
        H. James Thompson                              Robert C. Klas, Jr.

Title:  President                             Title:  President

Dated:       August 25, 1992                  Date:   August 25, 1992
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