<PAGE>

                    U.S. SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                  FORM 10-K/A
                                    (No. 1)

(Mark One)

|X|       Annual report under Section 13 or 15(d) of the Securities Exchange
          Act of 1934

          For the fiscal year ended December 31, 1997

|_|       Transition report under Section 13 or 15(d) of the Securities
          Exchange Act of 1934

          For the transition period from ________________ to ________________

          Commission file number   0-21168

                 CHROMATICS COLOR SCIENCES INTERNATIONAL, INC.
                 ---------------------------------------------
            (Exact Name of Registrant as Specified in Its Charter)

          NEW YORK                                  13-3253392
          --------                                  ----------
(State or Other Jurisdiction          (I.R.S. Employer Identification Number)
of Incorporation or Organization)

                 5 East 80th Street, New York, New York 10021
                 --------------------------------------------
              (Address of Principal Executive Offices)(Zip Code)

                                (212) 717-6544
                                --------------
             (Registrant's Telephone Number, Including Area Code)

        Securities registered under Section 12(b) of the Exchange Act:
                                     None

        Securities registered under Section 12(g) of the Exchange Act:

                   Common Stock, par value $0.001 per share
                   ----------------------------------------
                               (Title of Class)

         Indicate by check mark whether the registrant: (1) filed all reports
required to be filed by Section 13 or 15(d) of the Exchange Act during the
past 12 months (or for such shorter period that the registrant was required to
file such reports), and (2) has been subject to such filing requirements for
the past 90 days.

         Yes [X]   No [ ]

         Indicate by check mark if disclosure of delinquent filers in response
to Item 405 of Regulation S-K is not contained herein, and will not be
contained, to the best of registrant's knowledge, in definitive proxy or
information statements incorporated by reference in Part III of this Form 10-K
or any amendment to this Form 10-K. [ ]

         As of March 26, 1998, 14,717,827 shares of Common Stock, par value
$0.001 per share (the "Common Stock") of the registrant were outstanding and
the aggregate market value of the voting stock (computed based on the average
of the last bid and asked price on such date) held by non-affiliates was
approximately $158,566,740.

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         This amendment to the Company's Form 10-K is being filed to include
Exhibit 10.13, U.S. Patent No. 5,671,735.

                                    PART IV

Item 14.  Exhibits, Financial Statement Schedules and Reports on Form 8-K
          (a) and (d)1. Financial Statements

(a)       The following exhibits are included in this report:


Number    Description of Document
------    -----------------------

3.1       Restated Articles of Incorporation of the Company (incorporated by
          reference to Exhibit 3.1 to the Company's Registration Statement on
          Form S-1 (File No. 33-54256), filed on November 5, 1992, as amended
          (the "Registration Statement")).

3.1.1     Certificate of Amendment to the Certificate of Incorporation of the
          Company regarding the change of the Company's name (incorporated by
          reference to Exhibit 3.1.1 to the Registration Statement).

3.1.2     Certificate of Amendment to the Certificate of Incorporation of the
          Company increasing the authorized number of shares of Common Stock
          and increasing the authorized number of shares of Preferred Stock
          (incorporated by reference to Exhibit 3.1.2 to the Company's Annual
          Report on Form 10-KSB for the fiscal year ended December 31, 1996).

3.1.3     Certificate of Amendment to the Certificate of Incorporation of the
          Company dated February 13, 1998 effecting the three-for-two Stock
          Split and certain changes to the Class A Convertible Preferred
          Stock.

3.2       By-Laws of the Company (incorporated by reference to Exhibit 3.2 to
          the Registration Statement).

4.1       Specimen form of the Common Stock Certificate (incorporated by
          reference to Exhibit 4.1 to the Registration Statement).

9.1       Voting Proxy dated December 13, 1995, of David Kenneth Macfarlane to
          Darby Simpson Macfarlane (incorporated by reference to Exhibit 2 to
          Schedule 13D of Darby Macfarlane and Ken Macfarlane dated February
          12, 1996).

9.2       Voting Trust Agreement dated December 13, 1995, between David
          Kenneth Macfarlane and Darby Simpson Macfarlane (incorporated by
          reference to Exhibit 3 to Schedule 13D of Darby Macfarlane and Ken
          Macfarlane dated February 12, 1996).

10.1*     Form of Employment Agreement between the Company and Darby Simpson
          Macfarlane (incorporated by reference to Exhibit 10.1 to the
          Registration Statement).

10.2*     Form of Employment Agreement between the Company and David Kenneth
          Macfarlane (incorporated by reference to Exhibit 10.2 to the
          Registration Statement).

10.3*     Consulting Agreement, dated February 25, 1992, between the Company
          and Dr. Fred W. Billmeyer, Jr. (incorporated by reference to Exhibit
          10.4 to the Registration Statement).

10.4      Form of Indemnity Agreement between the Company and its directors
          and officers (incorporated by reference to Exhibit 10.6 to the
          Registration Statement).

10.5      Know-How Agreement, dated September 3, 1992, between the Company,
          Darby Simpson Macfarlane and David Kenneth Macfarlane (incorporated
          by reference to Exhibit 10.12 to the Registration Statement).

10.6      Assignment, dated September 3, 1992 from Darby Simpson Macfarlane to
          the Company regarding Intellectual Property (incorporated by
          reference to Exhibit 10.13 to the Registration Statement).

                                      2
<PAGE>

10.7**    Agreement, dated April 16, 1992, between the Company and IMS
          Cosmetics, Inc. (incorporated by reference to Exhibit 10.14 to the
          Registration Statement).

10.8      U.S. Patent No. 4,909,632 relating to Method for Selecting Personal
          Compatible Colors (incorporated by reference to Exhibit 10.17 to the
          Company's Annual Report on Form 10-KSB for the fiscal year ended
          December 31, 1994).

10.9      U.S. Patent No. 5,311,293 relating to Method and Instrument for
          Selecting Personal Compatible Colors (incorporated by reference to
          Exhibit 10.18 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

10.10     U.S. Patent No. 5,313,267 relating to Method and Instrument for
          Selecting Personal Compatible Colors (incorporated by reference to
          Exhibit 10.19 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

10.11     The Australian Patent relating to Method of Selecting Personal
          Compatible Color (incorporated by reference to Exhibit 10.20 to the
          Company's Annual Report on Form 10-KSB for the fiscal year ended
          December 31, 1994).

10.12     European Community Patent No. 0446512 relating to Method for
          Selecting Personal Compatible Colors (incorporated by reference to
          Exhibit 10.21 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

10.13+    U.S. Patent No. 5,671,735 relating to Method and Apparatus for
          Detecting and Measuring Conditions Affecting Color.

10.14     Assignment, dated October 30, 1992, between Darby Simpson Macfarlane
          and the Company relating to the Avon litigation (incorporated by
          reference to Exhibit 10.19 to the Registration Statement).

10.15     Know-How Assignment, dated October 30, 1992, from Pink & Peach
          Computer Corp. to the Company (incorporated by reference to Exhibit
          10.20 to the Registration Statement).

10.16     1992 Stock Option Plan (incorporated by reference to Exhibit 10.23
          to the Registration Statement). file owed.

10.17     Consulting Agreement dated January 6, 1995, between the Company and
          Janssen-Meyers Associates, L.P. (incorporated by reference to
          Exhibit 10.27 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

10.18     Warrant Agreement dated January 6, 1995, between the Company and
          Janssen-Meyers Associates, L.P. (incorporated by reference to
          Exhibit 10.28 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

10.19     Warrant Agreement dated March 13, 1995, between the Company and
          Janssen-Meyers Associates, L.P. (incorporated by reference to
          Exhibit 10.29 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

22        Subsidiaries of the Company (incorporated by reference to Exhibit 22
          to the Company's Post Effective Amendment No. 1 on Form SB-1 to the
          Registration Statement filed on January 11, 1994).

23        Consent of Independent Auditors.

27        Financial Data Schedule.

---------------------
*    Management contract or compensatory plan or arrangement required to be
     filed as an exhibit.
**   Confidential treatment has been requested with respect to certain
     information contained in this agreement.
+    Filed herewith.


                                      3
<PAGE>

                                  SIGNATURES

         In accordance with Section 13 or 15(d) of the Securities Exchange Act
of 1934, the registrant caused this report to be signed on its behalf by the
undersigned, thereunto duly authorized.

         CHROMATICS COLOR SCIENCES INTERNATIONAL, INC.

         By:  /s/ Darby S. Macfarlane,                  Date:  October 26, 1998
              ----------------------------------------
              Darby S. Macfarlane,
              Chief Executive Officer


         By:  /s/ Leslie Foglesong,                     Date:  October 26, 1998
              ----------------------------------------
              Leslie Foglesong,
              Treasurer
              (Chief Financial and Accounting Officer)


                                      4
<PAGE>


Exhibit Index

Number    Description of Document
------    -----------------------

3.1       Restated Articles of Incorporation of the Company (incorporated by
          reference to Exhibit 3.1 to the Company's Registration Statement on
          Form S-1 (File No. 33-54256), filed on November 5, 1992, as amended
          (the "Registration Statement")).

3.1.1     Certificate of Amendment to the Certificate of Incorporation of the
          Company regarding the change of the Company's name (incorporated by
          reference to Exhibit 3.1.1 to the Registration Statement).

3.1.2     Certificate of Amendment to the Certificate of Incorporation of the
          Company increasing the authorized number of shares of Common Stock
          and increasing the authorized number of shares of Preferred Stock
          (incorporated by reference to Exhibit 3.1.2 to the Company's Annual
          Report on Form 10-KSB for the fiscal year ended December 31, 1996).

3.1.3     Certificate of Amendment to the Certificate of Incorporation of the
          Company dated February 13, 1998 effecting the three-for-two Stock
          Split and certain changes to the Class A Convertible Preferred
          Stock.

3.2       By-Laws of the Company (incorporated by reference to Exhibit 3.2 to
          the Registration Statement).

4.1       Specimen form of the Common Stock Certificate (incorporated by
          reference to Exhibit 4.1 to the Registration Statement).

9.1       Voting Proxy dated December 13, 1995, of David Kenneth Macfarlane to
          Darby Simpson Macfarlane (incorporated by reference to Exhibit 2 to
          Schedule 13D of Darby Macfarlane and Ken Macfarlane dated February
          12, 1996).

9.2       Voting Trust Agreement dated December 13, 1995, between David
          Kenneth Macfarlane and Darby Simpson Macfarlane (incorporated by
          reference to Exhibit 3 to Schedule 13D of Darby Macfarlane and Ken
          Macfarlane dated February 12, 1996).

10.1*     Form of Employment Agreement between the Company and Darby Simpson
          Macfarlane (incorporated by reference to Exhibit 10.1 to the
          Registration Statement).

10.2*     Form of Employment Agreement between the Company and David Kenneth
          Macfarlane (incorporated by reference to Exhibit 10.2 to the
          Registration Statement).

10.3*     Consulting Agreement, dated February 25, 1992, between the Company
          and Dr. Fred W. Billmeyer, Jr. (incorporated by reference to Exhibit
          10.4 to the Registration Statement).

10.4      Form of Indemnity Agreement between the Company and its directors
          and officers (incorporated by reference to Exhibit 10.6 to the
          Registration Statement).

10.5      Know-How Agreement, dated September 3, 1992, between the Company,
          Darby Simpson Macfarlane and David Kenneth Macfarlane (incorporated
          by reference to Exhibit 10.12 to the Registration Statement).

10.6      Assignment, dated September 3, 1992 from Darby Simpson Macfarlane to
          the Company regarding Intellectual Property (incorporated by
          reference to Exhibit 10.13 to the Registration Statement).

10.7**    Agreement, dated April 16, 1992, between the Company and IMS
          Cosmetics, Inc. (incorporated by reference to Exhibit 10.14 to the
          Registration Statement).

10.8      U.S. Patent No. 4,909,632 relating to Method for Selecting Personal
          Compatible Colors (incorporated by reference to Exhibit 10.17 to the
          Company's Annual Report on Form 10-KSB for the fiscal year ended
          December 31, 1994).

10.9      U.S. Patent No. 5,311,293 relating to Method and Instrument for
          Selecting Personal Compatible Colors (incorporated by reference to
          Exhibit 10.18 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

                                      5
<PAGE>

10.10     U.S. Patent No. 5,313,267 relating to Method and Instrument for
          Selecting Personal Compatible Colors (incorporated by reference to
          Exhibit 10.19 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

10.11     The Australian Patent relating to Method of Selecting Personal
          Compatible Color (incorporated by reference to Exhibit 10.20 to the
          Company's Annual Report on Form 10-KSB for the fiscal year ended
          December 31, 1994).

10.12     European Community Patent No. 0446512 relating to Method for
          Selecting Personal Compatible Colors (incorporated by reference to
          Exhibit 10.21 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

10.13+    U.S. Patent No. 5,671,735 relating to Method and Apparatus for
          Detecting and Measuring Conditions Affecting Color.

10.14     Assignment, dated October 30, 1992, between Darby Simpson Macfarlane
          and the Company relating to the Avon litigation (incorporated by
          reference to Exhibit 10.19 to the Registration Statement).

10.15     Know-How Assignment, dated October 30, 1992, from Pink & Peach
          Computer Corp. to the Company (incorporated by reference to Exhibit
          10.20 to the Registration Statement).

10.16     1992 Stock Option Plan (incorporated by reference to Exhibit 10.23
          to the Registration Statement). file owed.

10.17     Consulting Agreement dated January 6, 1995, between the Company and
          Janssen-Meyers Associates, L.P. (incorporated by reference to
          Exhibit 10.27 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

10.18     Warrant Agreement dated January 6, 1995, between the Company and
          Janssen-Meyers Associates, L.P. (incorporated by reference to
          Exhibit 10.28 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

10.19     Warrant Agreement dated March 13, 1995, between the Company and
          Janssen-Meyers Associates, L.P. (incorporated by reference to
          Exhibit 10.29 to the Company's Annual Report on Form 10-KSB for the
          fiscal year ended December 31, 1994).

22        Subsidiaries of the Company (incorporated by reference to Exhibit 22
          to the Company's Post Effective Amendment No. 1 on Form SB-1 to the
          Registration Statement filed on January 11, 1994).

23        Consent of Independent Auditors.

27        Financial Data Schedule.

------------------------
*    Management contract or compensatory plan or arrangement required to be
     filed as an exhibit.
**   Confidential treatment has been requested with respect to certain
     information contained in this agreement.
+    Filed herewith.


                                      6