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                    Research & Funding
                    Research Programs & Contacts
                    Bioengineering, Biotechnology, & Imaging as applied to Diabetes, Metabolic, & Endocrine Diseases

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        Research Programs & Contacts
        Bioengineering, Biotechnology, & Imaging as applied to Diabetes, Metabolic, & Endocrine Diseases
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        Disease Biology
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                Clinical DevelopmentBioengineering, Biotechnology, & Imaging as applied to Diabetes, Metabolic, & Endocrine Diseases
    Cutting-edge technologies that elucidate the mechanisms underlying endocrine and metabolic diseases, including diabetes.
    The biomedical engineering, biotechnology, imaging, data science, and systems biology programs support research on the development and application of technologies and integrated approaches for the diagnosis, monitoring, and treatment of diabetes and other endocrine and metabolic diseases. Studies within these programs are aimed at:
Analyzing and interpreting protein structures that are relevant to metabolic and endocrine diseases
    Studying networks of molecules and cells including metabolites (metabolome), proteins (proteome), and neural systems (connectome) that are relevant to metabolic and endocrine diseases
    Developinglaboratory and computational tools and models and engineering platforms and solutionsto address the many roles of metabolites, proteins, and neural systems in the physiology and pathophysiology of metabolic and endocrine diseases
    Addressing the development and implementation of glucose sensors as well as their combination with insulin delivery systems to form a ‘closed-loop’ artificial pancreas
    Developing and applying in vivo molecular and functional imaging techniques to visualize and monitor physiological or metabolic processes and tissues (e.g., pancreatic beta cell mass, human brown adipose tissue, neural systems)
    Developing bioengineering solutions to prevent and treat diabetic foot ulcers, such as new biomaterials to facilitate healing, sensors to predict at-risk feet and novel devices to improve off-loading.
    NIDDK Program Staff
        Guillermo A. Arreaza-Rubín, M.D.
                    Diabetes and endocrine disease bioengineering and glucose sensing
                Arthur L. Castle, Ph.D.
                    Functional metabolomics and technology development to measure metabolic disease; muscle biology and exercise in diabetes and obesity; fellowships and institutional training grants
                Albert J. Hwa, Ph.D.
                    Basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and disease; generation of islet cells from stem cells for disease modeling and regenerative medicine; microphysiological systems for diabetes modeling
                Maren Laughlin, Ph.D.
                    Energy balance, thermogenesis and mitochondria biology, whole body intermediary carbohydrate, lipid and protein metabolism, and functional and metabolic imaging in adipose, pancreas and other metabolic organs.
                Yan Li, Ph.D.
                    Key regulators of intermediary metabolism; drug discovery; translational research; diabetic wound healing.
                Salvatore Sechi, Ph.D.
                    Proteomics, Systems Biology, and Structural Biology as applied to diabetes, metabolic, and endocrine diseases
                Xujing Wang, Ph.D.
                    Data science; computation modeling; integrative genomics; network biology; genotype-phenotype relationship
                Theresa Teslovich Woo, Ph.D.
                    Human behavior, developmental cognitive neuroscience, and brain-based mechanisms involved in obesity and diabetes
Recent Funding Opportunities
                    View More Recent Funding Opportunities
        Posted:
                                4/10/2024
                            PA-24-184
                    Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Required)
                    
                    Summary
                Posted:
                                4/9/2024
                            PA-24-185
                    Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Not Allowed)
                    
                    Summary
                Posted:
                                4/2/2024
                            PAR-24-206
                    Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)
                    
                    Summary
                Posted:
                                4/1/2024
                            RFA-DK-24-002
                    Adaptation of Diabetes Control Technologies for Older Adults with T1D  (R01 Clinical Trial Optional)
                    
                    Summary
                Posted:
                                4/1/2024
                            RFA-DK-25-008
                    Diabetes Research Centers (P30 Clinical Trial Optional)
                    
                    SummaryView More Recent Funding Opportunities
Related Links
Metabolomics Common Fund
    Protein Capture Reagents Common Fund
    Type 1 Diabetes Special Statutory Funding Program
    NIDDK Active Trials in Diabetes and Endocrine Disease
    View related clinical trials from ClinicalTrials.gov.
    NIH Study Sections
    Study sections conduct initial peer review of applications in a designated scientific area.
    Visit the NIH’s Center for Scientific Review website to search for study sections.Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
    NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
    NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.Additional Research Programs
ResearchTraining
NIDDK supports the training and career development of medical and graduate students, postdoctoral
fellows, and physician scientists through institutional and individual grants.
Learn about NIDDK Research Training Programs
Diversity
Diversity Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity Programs
Small Business
Small Business Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology
Transfer (STTR) programs.
These programs support innovative research conducted by small businesses that has the potential for
commercialization.
Learn about NIDDK Small Business Programs
Human SubjectsResearch
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
Learn about Human Subjects Research
TranslationalResearch
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries
into novel therapeutics.
Learn about NIDDK Translational Research Opportunities

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        Last Reviewed October 2023 Contact Us
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