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Research Programs & Contacts
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-  Gastrointestinal Immunology, Inflammation, & Inflammatory Diseases 
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  -  Target Identification 
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# Gastrointestinal Immunology, Inflammation, & Inflammatory Diseases

        Research on mucosal immunology, intestinal immunity, and inflammation in gastrointestinal diseases and conditions.    

The Gastrointestinal Immunology, Inflammation, and Inflammatory Diseases Program supports basic, clinical, and translational research on mucosal immunology, intestinal immunity, and inflammation in gastrointestinal diseases and conditions.  In particular, the program supports research on differentiation of gut-associated lymphoid tissue, regulation of innate and adaptive immune cell differentiation and function, genetic and epigenetic factors regulating immune responses and inflammation, the role of dietary components and nutrients in mediating inflammatory responses, the mechanisms by which the intestinal microbiota interact with the mucosal immune system to regulate inflammation and contribute to inflammatory diseases, immune response to enteric infections and antigens, and interactions between the immune and epithelial compartments in the gastrointestinal tract.  Translational research is encouraged to translate basic mechanisms regulating inflammation and the pathophysiology of inflammatory diseases into novel targets and therapeutic strategies for treating or preventing disease.  This program also supports clinical research, clinical trials, and epidemiology studies on gastrointestinal inflammatory diseases, including, but not limited to, gluten-sensitive enteropathy, inflammatory bowel disease, and gastritis; malabsorption syndromes; diarrhea; gastric and duodenal ulcers; and disease of the salivary glands (excluding cystic fibrosis).  The program also encourages epidemiology research to address risk factors for disease occurrence and disease prognosis or natural history, and it supports databases and biological repositories that advance clinical and epidemiological studies in digestive diseases and nutrition.

## NIDDK Program Staff

          -  Khoa Nguyen, PharmD                     HIV/AIDS comorbidities, complications, coinfections                
          -  Peter Perrin, Ph.D.                     Basic and Translational Mucosal Immunology and Inflammation                
          -  Terez Shea-Donohue, Ph.D.                     Basic and Translational Neurogastroenterology, Gastrointestinal Motility, Gastrointestinal Barrier Function, Mucosal Immunology and Inflammation                

## Recent Funding Opportunities

View More Recent Funding Opportunities
-  Posted:4/10/2024PA-24-184  Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Required)  Summary 
-  Posted:4/9/2024PA-24-185  Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Not Allowed)  Summary 
-  Posted:4/2/2024PAR-24-206  Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)  Summary 
-  Posted:3/27/2024NOT-OD-24-078  Notice of Special Interest (NOSI): Supporting the Exploration of Cloud in NIH-supported Research  Summary 
-  Posted:3/26/2024RFA-NS-25-012  HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)  Summary 

View More Recent Funding Opportunities

## Related Links

-    NIDDK Active Trials in Gastrointestinal Diseases  
View related clinical trials from ClinicalTrials.gov.
 
-    NIH Study Sections  
    Study sections conduct initial peer review of applications in a designated scientific area.    Visit the NIH’s Center for Scientific Review website to search for study sections.    
 

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## Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.

-  Ancillary Studies to Major Ongoing Clinical Studies  to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.    
-  NIDDK Central Repository  for access to clinical resources including data and biospecimens from NIDDK-funded studies.    
-  NIDDK Information Network (dkNET)  for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.    

## Additional Research Programs

### *Research*Training

NIDDK supports the training and career development of medical and graduate students, postdoctoralfellows, and physician scientists through institutional and individual grants.
Learn about NIDDK Research Training Programs

### Diversity

#### Diversity Programs

The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity Programs

### Small Business

#### Small Business Programs

NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business TechnologyTransfer (STTR) programs.These programs support innovative research conducted by small businesses that has the potential forcommercialization.
Learn about NIDDK Small Business Programs

### Human Subjects*Research*

#### Human Subjects Research

NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
Learn about Human Subjects Research

### Translational*Research*

NIDDK provides funding opportunities and resources to encourage translation of basic discoveriesinto novel therapeutics.
Learn about NIDDK Translational Research Opportunities

## Meetings & Workshops

                                dkNET                            
                                                                                Supports researchers with tools to enhance scientific rigor, reproducibility, and transparency, and provides a big data knowledge base for genomic and pathway hypothesis generation.                                                                                                                    

                                NIH Regional Seminars on Program Funding and Grants Administration                            
                                                                                Providing education and training for the next generation of biomedical and behavioral scientist                                                                                                                    

                                NIH Small Business (SBIR & STTR) Engage & Connect                            
                                                                                Stay informed about the latest events, or connect through social media.                                                                                                                    

                                View all Meetings & Workshops                            

View all Meetings & Workshops

          -    NIH Common Fund  
Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.
 
          -    Planning to Apply? Register Early  
Registration is required at eRA Commons and grants.gov and can take 4 weeks.