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          Labs @ NIAMS





Labs @ NIAMS X-ray of arthritic hand

        Labs at NIAMS
                              Our world-class investigators, staff, and trainees conduct research and clinical trials on the immune system, bones, joints, muscles, and skin. They develop novel diagnostic tools to analyze these systems and treatments for the diseases that affect them.
              New Video Series Offers Look Inside NIAMS Core Facilities
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      NIAMS’ Mariana Kaplan Named NIH Distinguished Investigator
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      2023 NIAMS Interns Return to In-person Research in IRP Labs
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Clinical Trials at NIAMS

      Explore clinical research studies for diseases of the immune system, bones, joints, muscles, and skin.
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Core Facilities

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              InVTRO summer program - 20242024 APPLICATIONS ARE NOW CLOSED
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      Two monocytes, with nuclei displaying the typical horseshoe shape.
  

    
            3D view of human monocytes - acquired using the Leica TCS SP8 X confocal scope, and applying a Z-stack acquisition modality to grab several focal planes along the Z-axis .
      Drosophila intestine
  

    
            Drosophila melanogaster intestine cross-section. Stained for Actin (PhTRITC- magenta), mitochondria (mito-GFP- green), and nucleus (DAPI- blue).
      Hela tubulin rings
  

    
            Hela tubulin rings induced by the anti-cancer drug Cryptophycin-52. Surfaces rendered by charge (left) and hydrophobicity (right).
      Swt1 in endothelial cells
  

    
            Detection of Swt1 (pink), a protein that localizes in the nuclear envelope, and mitochondria (yellow) in human glomerular microvascular endothelial cells (HGMECs).  DNA is in green.
      A YAC-1 tumor cell
  

    
            A YAC-1 tumor cell stained for alpha-tubulin to mark the microtubule cytoskeleton (green), CD107a (LAMP1) a marker of lysosomes (red), and DNA using the Hoechst 33342 nuclear dye (blue).
      Immunohistochemistry of oral buccal mucosa
  

    
            Immunohistochemistry of oral buccal mucosa detecting Annexin 1 (magenta), Keratin 5 (red) and SLPI (green)
      Immunofluoresecence of SAOS cells
  

    
            Immunofluoresecence of SAOS cells expressing GFP (teal) counterstained with DAPI (magenta)
      Immunocytochemistry of ameloblast-like cells
  

    
            Immunocytochemistry of ameloblast-like cells transfected to overexpress a mutant form of keratin 6 (red) associated with dental cavities. Counterstained with phalloidin (white) and Dapi (blue).


            In the Lab with NIAMS: Core FacilitiesImage
              Grid of four images showing the leaders of the NIAMS Core facilities. A new YouTube video series highlights the tools, such as powerful microscopes and advanced sequencing technologies, and the consultation, training, and data analysis services provided by the NIAMS Core Facilities. Watch the Videos.
      Scientific Advances
      
  

    
            Selected recent highlights of NIAMS intramural research:octubre 3, 2023The Transcription Factor STAT4 Controls the Fate of Cytotoxic Innate Lymphocytes
    septiembre 26, 2023Genetic Variants of PLCG2 Cause Immune Dysregulation Through Either Increased or Decreased Function
    septiembre 26, 2023The Microbiomes of People with Recombination-Activating Gene (RAG) Deficiency Have Distinct Features, Including Antimicrobial Resistance Signatures
    septiembre 23, 2023Neutrophil Extracellular Traps (NETs) Trigger Pathogenic Inflammation and Bone Loss in Periodontitis
    septiembre 22, 2023Possible Mechanism of a Rare Bone Overgrowth Disease Identified

      
  

    
      See All Advances
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              News from Labs @ NIAMS
      
  

    
            NIAMS' Dr. Michael J. Ombrello Interviewed by NIH Speaking of Science Podcast o...
Announcement | abril 4, 2024
    NIAMS’ Mariana Kaplan Named NIH Distinguished Investigator
Announcement | diciembre 7, 2023
    To Heal a Wound: Helping the Skin Fix Itself
NIH News in Health | octubre 2, 2023
    NIH scientists find treatment for rare genetic skin disorder
Press Release | junio 1, 2023

      
  

    
      View All News from Labs @ NIAMS
      Events
      
  

    
            Lupus Clinical Research poster - showing illustrated butterflies.
30th Anniversary of Lupus Clinical Research
Scientific Conference | May 31, 2024
    eular 24 - European Congress of Rheumatology
EULAR - European Congress of Rheumatology
Scientific Conference | Jun 12, 2024
- Jun 15, 2024
    Image of native american dancers.
SACNAS National Diversity in STEM Conference (NDiSTEM) 2023
Scientific Conference | Oct 31, 2024
- Nov 2, 2024
    ACR Convergence
ACR Convergence 2024 (Washington DC)
Scientific Conference | Nov 14, 2024
- Nov 19, 2024

      
  

    
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          Featured Expert      Mariana J. Kaplan, M.D.
          

    https://www.niams.nih.gov/es/node/1420
    
            Dr. Kaplan’s research focuses on identifying the molecular mechanisms that promote the initiation and perpetuation of perturbed immune responses and the development of organ damage and premature vascular disease in systemic autoimmunity.





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