26242 Federal Register / Vol. 74, No. 103 / Monday, June 1, 2009 / Notices 

of donations of personal property to 

public agencies for use in carrying out 

such purposes as conservation, 

economic development, education, 

parks and recreation, public health, and 

public safety. 

B. Annual Reporting Burden 

Respondents: 55. 

Responses per Respondent: 4. 

Total Responses: 220. 

Hours per Response: 1.5. 

Total Burden Hours: 330. 

Obtaining Copies of Proposals: 

Requesters may obtain a copy of the 

information collection documents from 

the General Services Administration, 

Regulatory Secretariat (VPR), 1800 F 

Street, NW., Room 4041, Washington, 

DC 20405, telephone (202) 501–4755. 

Please cite OMB Control No. 3090–0112, 

GSA Form 3040, State Agency Monthly 

Donation Report of Surplus Personal 

Property, in all correspondence. 

Dated: May 20, 2009. 

Casey Coleman, 

Chief Information Officer. 

[FR Doc. E9–12586 Filed 5–29–09; 8:45 am] 

BILLING CODE 6820–34–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Toxicology Program (NTP); 

NTP Interagency Center for the 

Evaluation of Alternative Toxicological 

Methods (NICEATM); Independent 

Scientific Peer Review Panel Report: 

Updated Validation Status of New 

Versions and Applications of the 

Murine Local Lymph Node Assay: A 

Test Method for Assessing the Allergic 

Contact Dermatitis Potential of 

Chemicals and Products: Notice of 

Availability and Request for Public 

Comments 

AGENCY: National Institute of 

Environmental Health Sciences 

(NIEHS), National Institutes of Health 

(NIH). 

ACTION: Request for comments. 

SUMMARY: NICEATM, in collaboration 

with the Interagency Coordinating 

Committee on the Validation of 

Alternative Methods (ICCVAM), 

convened an independent, 

international, scientific peer review 

panel (hereafter, Panel) on April 28–29, 

2009, to evaluate three non-radioactive 

modified versions and new applications 

for the Murine Local Lymph Node 

Assay (LLNA). The LLNA is an 

alternative test method that can be used 

to determine the allergic contact 

dermatitis potential of chemicals and 

products. The Panel report from this 

meeting is now available. The report 

contains (1) the Panel’s evaluation of the 

updated validation status of the 

methods and (2) the Panel’s comments 

on the updated draft ICCVAM test 

method recommendations. NICEATM 

invites public comment on the Panel’s 

report. The report is available on the 

NICEATM–ICCVAM Web site at http:// 

iccvam.niehs.nih.gov/docs/ 

immunotox_docs/ 

LLNAPRPRept2009.pdf or by contacting 

NICEATM at the address given below. 

DATES: Written comments on the Panel 

report should be received by July 15, 

2009. 

ADDRESSES: Comments should be 

submitted preferably electronically via 

the NICEATM–ICCVAM Web site at 

http://iccvam.niehs.nih.gov/contact/ 

FR_pubcomment.htm. Comments can 

also be submitted by e-mail to 

niceatm@niehs.nih.gov. Written 

comments can be sent by mail or fax to 

Dr. William S. Stokes, Director, 

NICEATM, NIEHS, P.O. Box 12233, Mail 

Stop: K2–16, Research Triangle Park, 

NC 27709; (fax) 919–541–0947. Courier 

address: NIEHS, NICEATM, 530 Davis 

Drive, Room 2035, Durham, NC 27713. 

FOR FURTHER INFORMATION CONTACT: Dr. 

William S. Stokes (telephone) 919–541– 

2384, (fax) 919–541–0947 and (e-mail) 

niceatm@niehs.nih.gov. 

SUPPLEMENTARY INFORMATION: 

Background 

In January 2007, the Consumer 

Product Safety Commission submitted a 

nomination to NICEATM and ICCVAM 

to assess the validation status of (1) the 

use of the LLNA to determine potency 

for hazard classification purposes, (2) 

LLNA protocols using non-radioactive 

procedures, (3) the LLNA limit dose 

procedure, and (4) the use of the LLNA 

to test mixtures, aqueous solutions, and 

metals (i.e., an updated assessment of 

the applicability domain of the LLNA). 

In June 2007, the Scientific Advisory 

Committee on Alternative Toxicological 

Methods (SACATM) endorsed these 

activities as high priorities for ICCVAM. 

NICEATM, on behalf of ICCVAM, also 

sought input from the public on these 

activities and requested data from 

studies using the LLNA or modified 

versions of the LLNA (72 FR 27815). 

After considering all comments 

received, ICCVAM endorsed carrying 

out these activities as high priorities. 

ICCVAM also developed draft LLNA 

performance standards to facilitate 

evaluation of modified LLNA protocols 

that are functionally and 

mechanistically similar to the 

traditional LLNA. These draft LLNA 

performance standards were made 

public and comments were requested in 

September 2007 (72 FR 52130). 

ICCVAM and NICEATM prepared 

draft background review documents 

(BRDs) that provided comprehensive 

reviews of available data and relevant 

information for each of the 

modifications and new applications of 

the LLNA. ICCVAM also developed 

draft test method recommendations 

regarding the proposed usefulness and 

limitations, standardized protocols, and 

future studies. NICEATM announced 

availability of the draft BRDs and draft 

recommendations for public comment 

and the public peer review meeting in 

January 2008 (73 FR 1360). 

The Panel met in public session on 

March 4–6, 2008, to review these topics, 

and their report was made available in 

May 2008 (73 FR 29136). The draft 

BRDs and draft test method 

recommendations, the draft ICCVAM 

LLNA test method performance 

standards, the Panel’s report, and all 

public comments were made available 

to SACATM for comment at their 

meeting on June 18–19, 2008 (73 FR 

25754). 

As a result of additional data received 

by ICCVAM subsequent to the March 

2008 Panel meeting, the draft BRDs for 

the following were updated: 

• The validation status of three 

modified LLNA test method protocols 

that do not require the use of radioactive 

substances. 

• The use of the LLNA for testing 

pesticide formulations, other products, 

and aqueous solutions. 

Second Meeting of the Peer Review 

Panel 

The Panel met again in public session 

on April 28–29, 2009 (74 FR 8974). The 

Panel reviewed the revised draft 

ICCVAM documents for completeness, 

errors, and omissions of any existing 

relevant data or information. The Panel 

evaluated the information in the revised 

draft documents to determine the extent 

to which each of the applicable criteria 

for validation and acceptance of 

toxicological test methods (ICCVAM, 

2003) had been appropriately addressed. 

The Panel then considered the ICCVAM 

draft recommendations for test method 

uses and limitations, proposed 

standardized protocol, proposed plans 

for development of test method 

performance standards, and proposed 

additional studies, and commented on 

the extent that the recommendations 

were supported by the information 

provided in the draft BRDs. 

Availability of the Peer Panel Report 

The Panel’s conclusions and 

recommendations are detailed in the 

Federal Register / Vol. 74, No. 103 / Monday, June 1, 2009 / Notices 26243 

Independent Scientific Peer Review 

Panel Report: Updated Validation 

Status of New Versions and 

Applications of the Murine Local Lymph 

Node Assay: A Test Method for 

Assessing the Allergic Contact 

Dermatitis Potential of Chemicals and 

Products (available at http:// 

iccvam.niehs.nih.gov/docs/ 

immunotox_docs/ 

LLNAPRPRept2009.pdf). The revised 

draft documents reviewed by the Panel 

and the draft ICCVAM test method 

recommendations are available at http:// 

iccvam.niehs.nih.gov/methods/ 

immunotox/llna_PeerPanel.htm. 

Request for Public Comments 

NICEATM invites the submission of 

written comments on the Panel’s report. 

When submitting written comments, 

please refer to this Federal Register 

notice and include appropriate contact 

information (name, affiliation, mailing 

address, phone, fax, e-mail, and 

sponsoring organization, if applicable). 

All comments received will be made 

publicly available via the NICEATM– 

ICCVAM Web site at http:// 

iccvam.niehs.nih.gov/methods/ 

immunotox/llna_PeerPanel.htm. In 

addition, there will be an opportunity 

for oral public comments on the Panel’s 

report during an upcoming meeting of 

SACATM scheduled for June 25–26, 

2009 (74 FR 19562). Information 

concerning the SACATM meeting is 

available at http://ntp.niehs.nih.gov/go/ 

7441. ICCVAM will consider the Panel 

report along with SACATM and public 

comments when finalizing test method 

recommendations. An ICCVAM test 

method evaluation report, which will 

include the final ICCVAM 

recommendations, will be forwarded to 

relevant Federal agencies for their 

consideration. The evaluation report 

will also be available to the public on 

the NICEATM–ICCVAM Web site at 

http://iccvam.niehs.nih.gov/methods/ 

immunotox/llna.htm and by request 

from NICEATM (see ADDRESSES above). 

Background Information on ICCVAM, 

NICEATM, and SACATM 

ICCVAM is an interagency committee 

composed of representatives from 15 

Federal regulatory and research agencies 

that use, generate, or disseminate 

toxicological information. ICCVAM 

conducts technical evaluations of new, 

revised, and alternative methods with 

regulatory applicability and promotes 

the scientific validation and regulatory 

acceptance of toxicological test methods 

that more accurately assess the safety 

and hazards of chemicals and products 

and that refine, reduce, and replace 

animal use. The ICCVAM Authorization 

Act of 2000 (42 U.S.C. 285l–3) 

established ICCVAM as a permanent 

interagency committee of the NIEHS 

under NICEATM. NICEATM 

administers ICCVAM and provides 

scientific and operational support for 

ICCVAM-related activities. NICEATM 

and ICCVAM work collaboratively to 

evaluate new and improved test 

methods applicable to the needs of U.S. 

Federal agencies. Additional 

information about ICCVAM and 

NICEATM can be found on their Web 

site (http://iccvam.niehs.nih.gov). 

SACATM was established January 9, 

2002, and is composed of scientists from 

the public and private sectors (67 FR 

11358). SACATM provides advice to the 

Director of the NIEHS, ICCVAM, and 

NICEATM regarding the statutorily 

mandated duties of ICCVAM and 

activities of NICEATM. Additional 

information about SACATM, including 

the charter, roster, and records of past 

meetings, can be found at http:// 

ntp.niehs.nih.gov/ see ‘‘Advisory Board 

& Committees’’ (or directly at http:// 

ntp.niehs.nih.gov/go/167). 

Reference 

ICCVAM. 2003. ICCVAM Guidelines for 

the Nomination and Submission of New, 

Revised, and Alternative Test Methods. NIH 

Publication No. 03–4508. Research Triangle 

Park, NC: NIEHS. Available at: http:// 

iccvam.niehs.nih.gov. 

Dated: May 19, 2009. 

John R. Bucher, 

Associate Director, NTP. 

[FR Doc. E9–12360 Filed 5–29–09; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Submission for OMB Review; 

Comment Request; Survey of NHLBI 

Constituents’ Health Information 

Needs and Preferred Formats 

Summary: Under the provisions of 

Section 3507(a)(1)(D) of the Paperwork 

Reduction Act of 1995, the National 

Heart, Lung and Blood Institute 

(NHLBI), the National Institutes of 

Health (NIH) has submitted to the Office 

of Management and Budget (OMB) a 

request for review and approval of the 

information collection listed below. 

This proposed information collection 

was previously published in the Federal 

Register on March 19, 2009, pages 

11736–11737 and allowed 60 days for 

public comment. No public comments 

were received. The purpose of this 

notice is to allow an additional 30 days 

for public comment. The National 

Institutes of Health may not conduct or 

sponsor, and the respondent is not 

required to respond to, an information 

collection that has been extended, 

revised, or implemented on or after 

October 1, 1995, unless it displays a 

currently valid OMB control number. 

Proposed Collection: Title: Survey of 

NHLBI Constituents’ Health Information 

Needs and Preferred Formats. Type of 

Information Collection Request: NEW. 

Need and Use of Information Collection: 

The purpose of this survey is to obtain 

information from NHLBI constituents 

(health professionals, patients and their 

families, and the general public) for the 

purpose of evaluating their health 

information and education needs and 

format preferences. The Consumer 

Services Team (CST) will use the data 

collected in this survey to create a 3- 

year Strategic Plan. The findings from 

the survey, described in the Strategic 

Plan, will be used to develop new 

health information materials for NHLBI 

constituents and to revise materials 

currently in the Institute’s portfolio. 

Frequency of Response: Once every 3 

years. Affected Public: Individuals. Type 

of Respondents: Individuals who have 

been consumers of NHLBI information 

within the past 3 years. The annual 

reporting burden is as follows: 

Estimated Number of Respondents: 

2,450; Estimated Number of Responses 

per Respondent: 1; Average Burden 

Hours per Response: 0.2; and Estimated 

Total Annual Burden Hours Requested: 

162. The annualized cost to respondents 

is estimated at: $3,518.62. There are no 

Capital Costs, Operating Costs and/or 

Maintenance Costs to report. 

Type of respondents 

Estimated 

number of 

respondents 

Estimated 

number of 

responses per 

respondent 

Average 

burden hours 

per response 

Estimated 

total annual 

burden hours 

requested 

General Public ................................................................................................. 1,075 0.33 0.2 71 

Private Companies .......................................................................................... 332 0.33 0.2 22