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                    Kidney Precision Medicine Project

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                Kidney Precision Medicine Project
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        Frequently Asked Questions: Kidney Precision Medicine Project (KPMP)
                Frequently Asked Questions: KPMP Recruitment Sites (RS)
                Frequently Asked Questions: KPMP Tissue Interrogation Sites (TIS)
                Frequently Asked Questions: KPMP Central Hub (CH)
                Frequently Asked Questions: KPMP Kidney Tissue Atlas Coordinating Center (KTACC)
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        Disease Biology
                Target Identification
                Assay Development
                Screening
                Hit to Lead
                Lead Optimization
                Pre-Clinical Development
                Clinical DevelopmentKidney Precision Medicine Project
    Identifying critical human cells, pathways, and targets for new therapies in acute and chronic kidney diseases.
    
The NIDDK Kidney Precision Medicine Project (KPMP) aims to ethically obtain and evaluate human kidney biopsies from participants
with Acute Kidney Injury (AKI) or Chronic Kidney Disease (CKD), create a kidney tissue atlas, define disease subgroups,
and identify critical cells, pathways, and targets for novel therapies. The project will have four distinct, but highly
interactive activities: Recruitment Sites, Tissues Interrogation Sites, a Central Hub and a Kidney Tissue Atlas Coordinating Center.
Additional technology development in support of the KPMP will be supported by small business programs.
KPMP Activities
View **detailed** KPMP Structure and Stages (PDF, 503.86 KB) .Expand All
    Recruitment Sites (RS)

Notice of funding opportunity number RFA-DK-20-026
Objective
Enroll adults with AKI and/or CKD from varied age, sex, racial, ethnic, socioeconomic, and geographic backgrounds into a longitudinal cohort study that includes a research kidney biopsy.
Total Funds Available
Approximately $3.7 million total costs per year for 5 years
Anticipated Number of Sites
Approximately 7 awards
Funding Mechanism
U01
Research Strategy Page Limit
12 pages
Staff Contacts
Paul Kimmel        - AKI
    Afshin Parsa - CKD
    Chris Ketchum        - General KPMPMore Information
General KPMP FAQs
    Recruitment Sites FAQsTissue Interrogation Sites (TIS)

Notice of funding opportunity number RFA-DK-20-028
Objective
Use and develop innovative technologies to analyze human kidney tissue.
Total Funds Available
Approximately $5 million total costs per year for 5 years
Anticipated Number of Sites
Approximately 8 awards
Funding Mechanism
U01
Research Strategy Page Limit
12 pages
Staff Contacts
Daniel Gossett - Tool and technology development
    Chris Ketchum - General KPMPMore Information
General KPMP FAQs
    Tissue Interrogation Sites FAQsCentral Hub (CH)

Notice of funding opportunity number RFA-DK-20-029
Objective
Collect and de-identify all clinical and social risk data and samples, and provide quality control, project management, and administrative support for the entire KPMP.
Total Funds Available
Approximately $4 million total costs per year for 5 years
Anticipated Number of Sites
One award
Funding Mechanism
U24
Research Strategy Page Limit
24 pages
Staff Contacts
Tracy Rankin
    Ivonne Schulman
    Chris Ketchum        - General KPMPMore Information
General KPMP FAQs
    Central Hub FAQsKidney Tissue Atlas Coordinating Center (KTACC)

Notice of funding opportunity number RFA-DK-20-027
Objective
Clean, harmonize, store and curate all de-identified KPMP data, perform integrative analyses, and create an interactive Kidney Tissue Atlas.
Total Funds Available
Approximately $2 million total costs per year
Anticipated Number of Sites
One award
Funding Mechanism
U01
Research Strategy Page Limit
12 pages
Staff Contacts
Eric Brunskill
Chris Ketchum - General KPMPMore Information
General KPMP FAQs
    Kidney Tissue Atlas Coordinating Center FAQsTechnology Development and Validation by Small Businesses

Notice of Special Interest: NOT-DK-21-007
Objective
This NOSI intends to encourage small businesses to translate kidney precision medicine discoveries and technologies.
Funding Mechanisms
R41/R42 (STTR) and R43/R44 (SBIR)
Staff Contact
Daniel Gossett
More Information
NIDDK SBIR/STTR Programs
Related Links
Innovative Science Accelerator (ISAC) Program
 Kidney Precision Medicine Project (KPMP)
    Kidney Precision Medicine Meeting
    2016
    Overcoming Barriers in Acute Kidney Injury (AKI)
    2015
    The Kidney Research National Dialogue: gearing up to move forward
    2014
    NIDDK Central Repository
    NIDDK Active Trials in Kidney Disease
    View related clinical trials from ClinicalTrials.gov.
    NIH Study Sections
    Study sections conduct initial peer review of applications in a designated scientific area.
    Visit the NIH’s Center for Scientific Review website to search for study sections.Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
    NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
    NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.Additional Research Programs
ResearchTraining
NIDDK supports the training and career development of medical and graduate students, postdoctoral
fellows, and physician scientists through institutional and individual grants.
Learn about NIDDK Research Training Programs
Diversity
Diversity Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity Programs
Small Business
Small Business Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology
Transfer (STTR) programs.
These programs support innovative research conducted by small businesses that has the potential for
commercialization.
Learn about NIDDK Small Business Programs
Human SubjectsResearch
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
Learn about Human Subjects Research
TranslationalResearch
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries
into novel therapeutics.
Learn about NIDDK Translational Research Opportunities

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        Last Reviewed October 2023 Contact Us
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