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          NIAMS Update
          NIAMS Update, Issue 3, 2023


NIAMS Update


NIAMS Update, Issue 3, 2023


NIAMS Update, Issue 3, 2022: Science News | Events | Funding Opportunities *June 29, 2023*
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    The *NIAMS Update*is produced and distributed by the NIAMS Science Communications and Outreach Branch. It is an online resource for the NIAMS Coalition, Council, and Colleagues.
      
        
      SPOTLIGHT
      
  

      Letter From the Director: Addressing Health Disparities and Moving Towards Health Equity



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              Photo of Dr, Lindsay Criswell


One of the major areas of focus for the most recent iteration of the historic Healthy People Initiative—Healthy People 2030—is achieving health equity and ensuring that people from all walks of life can access the health care that they need. NIAMS director Dr. Lindsey Criswell describes how the National Institutes of Health (NIH) is finding ways to remove barriers to health care access, a key component to achieving health equity.

Read more.

*Image: Lindsey A. Criswell, M.D., M.P.H., D.Sc.*
              NIH Researchers Survey the Genetic Diversity of Skin Microbes in Eczema Patients



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              Genetic Diversity of Skin Microbes in Eczema Patients


Using genetic sequencing techniques, NIAMS researchers led byHeidi H. Kong, M.D., M.H.Sc., and researchers at the National Human Genome Research Institute surveyed the skin microbiome of patients with atopic dermatitis (also called eczema) to understand the genetic diversity of the bacteria present on the skin and how genetic variants may contribute to disease severity.



Targeted Research to Improve Joint Pain: The Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium



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              Knee Joint Image


Scientists from the RE-JOIN Consortium are using innovative technology to better visualize and understand joint pain, to help identify non-opioid treatment strategies for chronic pain. This article highlights the research plans of several RE-JOIN-funded scientists. RE-JOIN is part of the NIH Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®.



Pain Relief for Carpal Tunnel Syndrome



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              Carpal tunnel


In a HEAL project supported by NIAMS and the National Institute of Neurological Disorders and Stroke, researchers tested non-invasive stimulation on the scalp to calm the brain to relieve carpal tunnel syndrome pain. Patients receiving treatment reported less pain and improvements in the ability to use their hands.



Research Into Naturally Occurring Hair Growth in Skin Nevi May Inform New Regenerative Therapies



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              spotlight-hair-growth


Researchers funded in part by NIAMS have identified a potential target for regenerative therapies in hair disorders. The work suggests a possible role for aged (or senescent) cells in stimulating hair growth.



Aging Melanocyte Stem Cells and Gray Hair



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              Gray Hair


Melanocytes, the cells that produce the pigment responsible for skin and hair color, arise from melanocyte stem cells. Scientists found that in aging mice, more and more melanocyte stem cells do not migrate into the location and position necessary for making melanocytes during each hair growth cycle. These “stuck” cells may help explain hair graying in older individuals.

NIH Scientists Find Treatment for Rare Genetic Skin Disorder



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              Rare skin disorder


NIH researchers and grantee colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea. The work also identified a drug that significantly improved symptoms in patients.



NIAMS Scientific Director of Intramural Research, Dr. John O'Shea, Elected to the U.S. National Academy of Sciences



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              John O’Shea, M.D


NIAMS Scientific Director of Intramural Research, John O’Shea, M.D., was elected to the U.S. National Academy of Sciences at the conclusion of the Academy’s 160th annual meeting on May 2, 2023. This designation—considered one of the highest honors that a scientist can achieve—recognizes distinguished and continuing achievements in original research.



NIAMS Awards Two Fiscal Year (FY) 2022 Supplements to Advance Research (STAR) From Projects to Programs—Enhancing NIH Support for Early Career Stage Investigators



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              Danelle N. Devenport, Ph.D & Yvonne C. Lee, M.D.,


The NIAMS STAR program provided two funding supplements to early career stage investigators who have renewed their first NIAMS-funded R01 grant:
 **Danelle N. Devenport, Ph.D.,** is an associate professor of molecular biology at Princeton University. She leads a NIAMS-funded research project to better understand the collective polarization and alignment of cells across a tissue—a phenomenon known as planar cell polarity.
 **Yvonne C. Lee, M.D.,** is the Helen Myers McLoraine Professor of rheumatology and an associate professor of medicine (rheumatology) and preventive medicine (epidemiology) at Northwestern University. Dr. Lee is the principal investigator of a NIAMS-supported research project studying how rheumatoid arthritis leads to changes in central nervous system pathways responsible for sensing, transmitting, and regulating pain.



ARPA-H Launches NITRO Program to Help Joints Heal Themselves



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              Knee OA ARPA


The U.S. Advanced Research Projects Agency for Health (ARPA-H) announced its first new program, Novel Innovations for Tissue Regeneration in Osteoarthritis (NITRO). NITRO seeks to use a patient’s own cells to regenerate lost bone and cartilage. ARPA-H was launched last year, modeled on the applications-focused, outside-the-box science sponsored by the Defense Advanced Research Projects Agency.



The Foundation for the National Institutes of Health Announces Selection of Eight Rare Diseases for the Bespoke Gene Therapy Consortium Clinical Trial Portfolio



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              DNA Helix


The Accelerating Medicines Partnership® Bespoke Gene Therapy Consortium (AMP® BGTC) selected eight rare diseases for its clinical trial portfolio. With the selection, BGTC will begin its work

of streamlining the gene therapy development process to make it more generalizable and accessible for many other rare genetic diseases.



NIH MedlinePlus Magazine: *Zain Verjee Is No Longer Hiding From Psoriasis*



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              Zain Verjee


As a leading international journalist on CNN, Zain Verjee’s face was visible to millions of people every day. But she “spent a lifetime hiding” as she dealt with psoriasis, a chronic skin disease that causes itchy or sore patches of thick, red skin with silvery scaling.



FDA Approves First Topical Gene Therapy for Treatment of Wounds in Patients With Dystrophic Epidermolysis Bullosa

The U.S. Food and Drug Administration (FDA) approved Vyjuvek, a herpes-simplex virus type 1 vector-based gene therapy, for the treatment of wounds in patients 6 months of age and older with dystrophic epidermolysis bullosa, which can cause blisters on the skin, with mutation(s) in the collagen type VII alpha 1 chain gene.



FY 2023 Funding Plan

NIAMS is operating under the FY 2023 Consolidated Appropriations Act signed by President Biden on December 29, 2022.
              Funding Opportunities
      
  

      NIAMS Clinical Trial Planning Grant (R34) – Clinical Trial Not Allowed (PAR-22-205)

Next application due date: July 2, 2023

Ancillary Studies to Ongoing Clinical Projects (R01 Clinical Trial Not Allowed) (PAR-23-025)

Next application due date: August 7, 2023

Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed) (PAR-23-026)

Next application due date: August 7, 2023

Core Centers for Clinical Research (CCCR) (P30 Clinical Trial Not Allowed) (RFA-AR-24-003)

Application due date: September 12, 2023

HEAL Initiative: Planning Studies for Initial Analgesic Development [Small Molecules and Biologics] (R61 Clinical Trial Not Allowed) (RFA-NS-21-029)

Next application due date: October 10, 2023

All Open HEAL Opportunities List

Notice of Special Interest (NOSI): Supporting Exploratory/Developmental Research Focused on NIAMS Core Mission Areas (NOT-AR-23-006)

Next application due date: October 16, 2023

Notice of Intent to Publish a Funding Opportunity Announcement for Established Data Repositories and Knowledgebases (Clinical Trials Not Allowed) (NOT-OD-23-099)

NIH intends to promote an initiative by publishing a funding opportunity to solicit applications for established biomedical data repositories or knowledge bases. NIH’s goal is to support a seamless repository ecosystem to ensure that data and other digital objects resulting from NIH research can be stored and shared with the research community, in accordance with the goals set forth in the NIH Strategic Plan for Data Science.

First estimated due date: Fall 2023
              Resources
      
  

      Spotlight on Scientific Imagery: B Cells Contribute to Bone Loss in Rheumatoid Arthritis



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              Spotlight on Scientific Imagery


Joint tissue from patients with rheumatoid arthritis (RA) contains high numbers of B cells (white), the antibody-producing cells of the immune system. These cells produce high levels of the signaling molecule RANKL (green), which stimulate osteoclasts (red), causing bone to break down. Researchers aim to identify the specific B cell subsets and molecular pathways involved in the cells’ harmful effects so that they can find ways to target them selectively. The ultimate goal is to develop new RA treatments with fewer unwanted side effects.

*Photo Credit: Jennifer Anolik, M.D., Ph.D., University of Rochester*

NIAMS Is Now on LinkedIn



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              NIAMS is now on LinkedIn


NIAMS is on LinkedIn! Follow us to keep up with the latest institute news and updates, funding opportunities, research news, job openings, and more.

NEW, Updated NIAMS Social Media Toolkit



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              Have you checked up on your bone health lately? NIAMS can help you get started with free health info!


NIAMS has developed digital resources in both English and Spanish to help facilitate sharing health information about bones, muscles, joints, and skin diseases with colleagues, friends, family, and community members. On this page, you will find ready-to-use graphics and sample messages to download and share in newsletters, via email, and across social media platforms. The graphics are free to use and share without copyright restrictions. Access the toolkit here.

Osteoporosis and Bone Health Topics Have Moved to the Main NIAMS Website

The NIAMS website now serves as the go-to source for reliable information on osteoporosis, bone health, and related diseases and conditions. Health information previously found on the NIH Osteoporosis and Related Bone Diseases National Resource Center website (bones.nih.gov) was recently migrated to the NIAMS website.
              Events
      
  

      August NIAMS Advisory Council Meeting (Hybrid Meeting)

The next NIAMS Advisory Council Meeting will be a hybrid meeting on August 29, 2023. The meeting will be available for viewing via the NIH videocasting service. A video recording of the recent NIAMS Advisory Council Meeting on June 6, 2023, is available.



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              Advisory Council, January 2023 screen grab

**Credit** NIAMS


Understanding and Restoring Whole Joint Health in Pain Management: An NIH HEAL Initiative Workshop Sponsored by the National Center for Complementary and Integrative Health

July 25 and 26, 2023AgendaRegister

NIH Science Lectures and Events Available via Internet

Look for past videocasts, including:

18th Annual Pain Consortium Symposium on Advances in Pain Research (Day 1)—June 2023
	18th Annual Pain Consortium Symposium on Advances in Pain Research (Day 2)—June 2023
	Autoinflammatory Disease and the Human Condition—June 2023*For additional online science seminars and events hosted by NIH, view the NIH VideoCast Future Events and the NIH calendar.* 
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