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                    Human Energy & Body Weight Regulation Core

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        Cores & Support Services
        Advanced Light Microscopy & Image Analysis Core
                Clinical Laboratory Core
                Clinical Mass Spectrometry Core
                Computational Biomolecular Magnetic Resonance Core
                Cryo-Electron Microscopy (Cryo-EM) Core, NIDDK
                Cryo-Electron Microscopy (Cryo-EM) Core, Multi-Institute (MICEF)
                Genomics Core
                Human Energy & Body Weight Regulation Core
                Laboratory of Animal Sciences Section
                Mouse CRISPR/Cas9 Genome Editing Facility
                Mouse Metabolism CoreHuman Energy & Body Weight Regulation Core
    **Kong Y. Chen, Ph.D., Director**
View staff and contact information.
The Human Energy and Body Weight Regulation Core provides metabolic testing for the
Metabolic Clinical Research Unit (MCRU) and throughout the NIH Clinical Center.
The Core collaborates with investigators from across the NIDDK, clinical research programs at the NIH, and other institutions
by performing metabolic and physiological phenotyping measurements in healthy volunteers as they relate to obesity,
physical activity, and energy metabolism, and in patients with metabolic disorders as they relate to specific metabolic
dysregulations.
The Core supports the collection of highly sensitive, continuous measurements of whole-body energy metabolism. We use standard
bedside indirect calorimetry measurements of resting energy expenditure and whole-room indirect calorimeters (metabolic
chambers) over a 24-hour period. We measure sleep, post-prandial, resting, exercise, recovery, and spontaneous movement
periods; substrate oxidation rates over 24 hours; physical activity during free living; heart rate and heart-rate
variability; and skin and core body temperatures.
The Core also provides standardized measurements of cardio-respiratory fitness (maximum and submaximum tests performed using
upright, recumbent, and treadmill) and body composition (collected using dual energy x-ray absorptiometry (DXA),
air-displacement plethysmography (BodPod), bioelectrical impedance, and anthropometry). In addition, staff members
advise and consult with clinical research teams to optimize measurement selection and protocol design. Finally, Core
members coordinate and provide measurement services, perform routine equipment calibrations and maintenance, and
manage related data.
        Last Reviewed June 2023 Contact Us
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