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          About NIAMS
          Maria I. Morasso, Ph.D.





Maria I. Morasso, Ph.D.


Senior Investigator
    Chief, Laboratory of Skin Biology Image
              Maria I. Morasso, Ph.D. 
            Contact Information

                                                  301-435-7842
                
                                                9000 Rockville Pike
                  
            50 South Drive
      
                  
            Building 50, Room 1523
      
                                   Bethesda MD 20892
                
                                                morassom@mail.nih.gov 
                Summary
          Maria Morasso, PH.D. received an M.Sc. in Immunology and a Ph.D. in Biochemistry from the Instituto Venezolano de Investigaciones Científicas, Venezuela. Her postdoctoral training was in the Laboratory of Molecular Genetics in the National Institute of Child Health and Human Development, NIH. In 2000, Dr. Morasso moved to the National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH where she is currently a senior investigator and chief of the Laboratory of Skin Biology. Dr. Morasso is also serving as an adjunct investigator at the Center for Cancer Research, NCI.

The Morasso lab aims to understand the function of specific transcriptional regulators and pathways in molecular and cellular processes that contribute to epidermal differentiation and barrier formation, wound repair and the mechanisms underlying the pathologies of ectodermal dysplasias (EDs). 

            Scientific Publications
              Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity.

    Williams DW, Greenwell-Wild T, Brenchley L, Dutzan N, Overmiller A, Sawaya AP, Webb S, Martin D, NIDCD/NIDCR Genomics and Computational Biology Core, Hajishengallis G, Divaris K, Morasso M, Haniffa M, Moutsopoulos NM
        

                    Cell.
        
                    2021 Jul 22;
        
                    184(15).
        
                    doi: 10.1016/j.cell.2021.05.013
                            PMID: 34129837
  Loss of DLX3 tumor suppressive function promotes progression of SCC through EGFR-ERBB2 pathway.

    Bajpai D, Mehdizadeh S, Uchiyama A, Inoue Y, Sawaya A, Overmiller A, Brooks SR, Hasneen K, Kellett M, Palazzo E, Motegi SI, Yuspa SH, Cataisson C, Morasso MI
        

                    Oncogene.
        
                    2021 May;
        
                    40(21).
        
                    doi: 10.1038/s41388-021-01802-9
                            PMID: 33947961
  Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing.

    Sawaya AP, Stone RC, Brooks SR, Pastar I, Jozic I, Hasneen K, O'Neill K, Mehdizadeh S, Head CR, Strbo N, Morasso MI, Tomic-Canic M
        

                    Nat Commun.
        
                    2020 Sep 16;
        
                    11(1).
        
                    doi: 10.1038/s41467-020-18276-0
                            PMID: 32938916
  SOX2 Epidermal Overexpression Promotes Cutaneous Wound Healing via Activation of EGFR/MEK/ERK Signaling Mediated by EGFR Ligands.

    Uchiyama A, Nayak S, Graf R, Cross M, Hasneen K, Gutkind JS, Brooks SR, Morasso MI
        

                    J Invest Dermatol.
        
                    2019 Aug;
        
                    139(8).
        
                    doi: 10.1016/j.jid.2019.02.004
                            PMID: 30772301
  Do DLX3 and CD271 Protect Human Keratinocytes from Squamous Tumor Development?

    Palazzo E, Marconi A, Pincelli C, Morasso MI
        

                    Int J Mol Sci.
        
                    2019 Jul 19;
        
                    20(14).
        
                    doi: 10.3390/ijms20143541
                            PMID: 31331058
  Ectodermal dysplasias: Classification and organization by phenotype, genotype and molecular pathway.

    Wright JT, Fete M, Schneider H, Zinser M, Koster MI, Clarke AJ, Hadj-Rabia S, Tadini G, Pagnan N, Visinoni AF, Bergendal B, Abbott B, Fete T, Stanford C, Butcher C, D'Souza RN, Sybert VP, Morasso MI
        

                    Am J Med Genet A.
        
                    2019 Mar;
        
                    179(3).
        
                    doi: 10.1002/ajmg.a.61045
                            PMID: 30703280
  Enamel Anomalies in a Pachyonychia Congenita Patient with a Mutation in KRT16.

    Duverger O, Cross MA, Smith FJD, Morasso MI
        

                    J Invest Dermatol.
        
                    2019 Jan;
        
                    139(1).
        
                    doi: 10.1016/j.jid.2018.07.005
                            PMID: 30009827
  Transcriptional signature primes human oral mucosa for rapid wound healing.

    Iglesias-Bartolome R, Uchiyama A, Molinolo AA, Abusleme L, Brooks SR, Callejas-Valera JL, Edwards D, Doci C, Asselin-Labat ML, Onaitis MW, Moutsopoulos NM, Gutkind JS, Morasso MI
        

                    Sci Transl Med.
        
                    2018 Jul 25;
        
                    10(451).
        
                    doi: 10.1126/scitranslmed.aap8798
                            PMID: 30045979
  Hair keratin mutations in tooth enamel increase dental decay risk.

    Duverger O, Ohara T, Shaffer JR, Donahue D, Zerfas P, Dullnig A, Crecelius C, Beniash E, Marazita ML, Morasso MI
        

                    J Clin Invest.
        
                    2014 Dec;
        
                    124(12).
        
                    doi: 10.1172/JCI78272
                            PMID: 25347471


Last Updated: June 2023


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