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		Search Text: Clinical Trials
					
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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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      How Clinical Trials Work
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      Benefits, Risks & Safety Measures
Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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Clear AllPulmonary Hypertension
Showing 1 - 10 out of 21 results
      
      Right Ventricle Lipid in Pulmonary Arterial Hypertension (PAH)
      Recruiting
                          Tennessee
        The investigators propose to study the relationship between right ventricle (RV) steatosis and RV function, exercise capacity, and outcomes in humans with pulmonary arterial hypertension (PAH) and to identify potential drivers of lipid accumulation.
      Pulmonary Hypertension
                          Adult, Older Adult
    The MObile Health InterVEntion in Pulmonary Arterial Hypertension (MOVE PAH) Study
      Recruiting
                          Tennessee
        The Investigators propose a randomized trial of smart texts versus usual care for 6 months. The Investigators will randomize 100 PAH patients to the mHealth intervention or usual care. The Investigators will test the effect of a text-based mHealth intervention on HRQOL in PAH using the PAH-specific emPHasis-10 questionnaire. The Investigators will also test the effect of an mHealth intervention on exercise capacity, measured by a supervised home-based 6MWD test. Finally, the Investigators will examine the effect of the intervention on time to clinical worsening (composite of PAH therapy escalation, PAH hospitalization, and death) one year after randomization.
      Pulmonary Hypertension
                          Adult, Older Adult
    Breaking up Prolonged Sedentary Behavior to Improve Cardiometabolic Health
      Recruiting
                          New York
        Are you a healthy adult who wants to join a study about less sitting? You might qualify for this research. Researchers are testing if walking breaks can improve cardiovascular health, like blood pressure and glucose (sugar) levels. To join, you must be 18 years old and have no long-term health issues or not be taking medications for blood pressure or diabetes. Participants will have to go to the study site for a 9-hour visit and walk on a treadmill during the day. The study is taking place in New York City, New York.
      Physical Activity and Your Heart
              Heart-Healthy Living
              Pulmonary Hypertension
              High Blood Pressure
              Low Blood Pressure
                          Adult, Older Adult
                                      Accepting Healthy Volunteers
    Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
      Recruiting
                          North Carolina
        The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.
      Pulmonary Hypertension
              Low Blood Pressure
              High Blood Pressure
                          Adult
                                      Accepting Healthy Volunteers
    PET Image in PAH Patients
      Recruiting
                          Pennsylvania
        Investigators will conduct in-human PET imaging of 18F-fluoroglutamine (18F-FGln) in patients with PAH to compare glutamine uptake to that of controls.
      Pulmonary Hypertension
                          Adult, Older Adult
                                      Accepting Healthy Volunteers
    Team-Based Home Blood Pressure Monitoring
      Recruiting
                          New York
        Do you have high blood pressure? In this clinical trial, researchers are studying different ways to improve home blood pressure monitoring. You may be able to participate if you are between 18 and 85 years old and diagnosed with high blood pressure. Participants will work closely with clinicians or other healthcare providers to schedule appointments, coordinate care, measure blood pressure, answer your questions, and treat your high blood pressure. The study is taking place in Rochester, New York.
      High Blood Pressure
              Low Blood Pressure
              Pulmonary Hypertension
                          Adult, Older Adult
    Right Ventricle Lipid in Pulmonary Arterial Hypertension (PAH)
      Recruiting
                          Tennessee
        The investigators propose to study the relationship between right ventricle (RV) steatosis and RV function, exercise capacity, and outcomes in humans with pulmonary arterial hypertension (PAH) and to identify potential drivers of lipid accumulation.
      Pulmonary Hypertension
                          Adult, Older Adult
    The MObile Health InterVEntion in Pulmonary Arterial Hypertension (MOVE PAH) Study
      Recruiting
                          Tennessee
        Patients with pulmonary arterial hypertension (PAH) have reduced health related quality of life (HRQOL) and impaired exercise capacity. Despite fourteen approved therapies, most patients die within ten years. Increasing physical activity is highly efficacious in PAH, resulting in six-minute walk distance (6MWD) and HRQOL improvement that often exceeds the effect of medications. Prior activity studies required inpatient rehabilitation, which is impractical, hard to sustain, and poorly scalable to a rare disease.
The Investigators propose a randomized trial of smart texts versus usual care for 6 months. The Investigators will randomize 100 PAH patients to the mHealth intervention or usual care. The Investigators will test the effect of a text-based mHealth intervention on HRQOL in PAH using the PAH-specific emPHasis-10 questionnaire. The Investigators will also test the effect of an mHealth intervention on exercise capacity, measured by a supervised home-based 6MWD test. Finally, the Investigators will examine the effect of the intervention on time to clinical worsening (composite of PAH therapy escalation, PAH hospitalization, and death) one year after randomization.
      Pulmonary Hypertension
                          Adult, Older Adult
    Risk Underlying Rural Areas Longitudinal Cohort Study (RURAL) Heart and Lung Study
      Recruiting
                          Alabama
        Have you lived in Alabama, Kentucky, Louisiana, or Mississippi for at least two years and are you interested in participating in a clinical study where researchers are trying to better understand health and disease in rural areas? The study team will track your physical activity using a provided Fitbit device and will also ask questions about your health and lifestyle through a cell phone app. You will also receive a kit to measure environmental and health factors in your homes. Participants must live in one of these counties: Dallas County, Alabama; Wilcox County, Alabama; Boyle County, Kentucky; Perry County, Kentucky; Garrard County, Kentucky; Breathitt County, Kentucky; Assumption Parish, Louisiana; Franklin Parish, Louisiana; Oktibbeha County, Mississippi; and Panola County, Mississippi.
      Pulmonary Hypertension
              Coronary Heart Disease
                          Adult
                                      Accepting Healthy Volunteers
    PET Image in PAH Patients
      Recruiting
                          Pennsylvania
        The proposed research study will provide preliminary evidence of the potential to utilize [F-18]FGln as a non-invasive imaging biomarker of glutamine flux and metabolism across a range of PAH subjects.
      Pulmonary Hypertension
                          Adult, Older Adult
                                      Accepting Healthy Volunteers
  
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