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                    Genomics Core

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        Cores & Support Services
        Advanced Light Microscopy & Image Analysis Core
                Clinical Laboratory Core
                Clinical Mass Spectrometry Core
                Computational Biomolecular Magnetic Resonance Core
                Cryo-Electron Microscopy (Cryo-EM) Core, NIDDK
                Cryo-Electron Microscopy (Cryo-EM) Core, Multi-Institute (MICEF)
                Genomics Core
                Human Energy & Body Weight Regulation Core
                Laboratory of Animal Sciences Section
                Mouse CRISPR/Cas9 Genome Editing Facility
                Mouse Metabolism CoreGenomics Core
    **John A. Hanover, Ph.D., DirectorHarold Smith, Ph.D., Lead Scientist, sequencing services and bioinformatics**
View staff and contact information.
The Genomics Core provides next-generation sequencing (NGS) on a fee-for-service basis to the NIH community, with priority
for NIDDK users. Additional resources in support of this technology included consultation services, user-accessible
instrumentation, bioinformatics infrastructure, and secure data management.
The facility offers next-generation (massively parallel) sequencing on the Illumina platform (HiSeq 3000, NextSeq 550, and MiSeq). Users
provide libraries to the facility, and submit library information via the sample tracking website. Core personnel
assess library quality, perform sequencing, assess data quality, and perform alignment. Data is returned to users
by secure FTP. Front-end support includes assistance with experimental design and advice on library preparation.
The facility houses a shared instrumentation laboratory and provides training for users. Instruments are available
for sample shearing, automated chromatin immunoprecipitation, automated library construction, library quality assessment
and purification, and real-time qPCR. Users also have access to integrated software packages for NGS data analysis.
Additional bioinformatics support from Core personnel may be available on an ad hoc, collaborative basis.
NIH staff members are encouraged to contact Harold Smith or Ilhan Akan to discuss the application of facility
services to their research programs, or to schedule a visit to the laboratory (located in Building 8, Room 1A11).
The Genomics Core Facility was created in January 2003 to provide investigators
with innovative, genome-scale technologies in gene expression and DNA sequencing.
For NIDDK Staff Only:
Learn how to utilize the Core’s services.
        Last Reviewed June 2023 Contact Us
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