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          About NIAMS
          Stefania Dell'Orso, Ph.D.





Stefania Dell'Orso, Ph.D.


Staff Scientist
    Chief, Genomic Technology Section
    Office of Science and Technology Image
              Headshot of a woman in a lab with long hair. 
            Contact Information

                                                  301-451-9544
                
                                                9000 Rockville Pike
                  
                  
            Building 50, Room 1345
      
                                   Bethesda MD 20892
                
                                                dellorsos@mail.nih.gov 
                                          Media Resources
                                High Resolution Image
                stefania-dell-orso.jpg 
                Summary
          Dr. Dell’Orso received her Ph.D. from the University of Rome in Italy and conducted her post-doc research at the NIAMS where she focused on the role of transcription factors, chromatin regulators, ncRNAs and epigenetic marks during skeletal muscle specification and development. In 2016 she joined the NIAMS Genomic TechnologySection where she providesconsultation on experimental design and library preparation and works with NIAMS scientists to implement genomics and sequencing technologies.
        
                  Research Statement
          
            TheGenomic Technology Section at NIAMS is a multi-disciplinary genomics facility that supportsNIAMS investigatorswiththe latest on DNA sequencing and library preparation technologies.The****Section works closely with NIAMS scientists to explore the use and implementation of leading edge genomics technologies, molecular biology protocols and analytical procedures as well as consultation and training for researchers with specific needs or challenging problems. 

            Scientific Publications
              Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

    Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, Pei W, Balanda N, Ross DL, Ospina Cardona D, Wu Z, Patel B, Manthiram K, Groarke EM, Gutierrez-Rodrigues F, Hoffmann P, Rosenzweig S, Nakabo S, Dillon LW, Hourigan CS, Tsai WL, Gupta S, Carmona-Rivera C, Asmar AJ, Xu L, Oda H, Goodspeed W, Barron KS, Nehrebecky M, Jones A, Laird RS, Deuitch N, Rowczenio D, Rominger E, Wells KV, Lee CR, Wang W, Trick M, Mullikin J, Wigerblad G, Brooks S, Dell'Orso S, Deng Z, Chae JJ, Dulau-Florea A, Malicdan MCV, Novacic D, Colbert RA, Kaplan MJ, Gadina M, Savic S, Lachmann HJ, Abu-Asab M, Solomon BD, Retterer K, Gahl WA, Burgess SM, Aksentijevich I, Young NS, Calvo KR, Werner A, Kastner DL, Grayson PC
        

                    N Engl J Med.
        
                    2020 Dec 31;
        
                    383(27).
        
                    doi: 10.1056/NEJMoa2026834
                            PMID: 33108101
  FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age.

    García-Prat L, Perdiguero E, Alonso-Martín S, Dell'Orso S, Ravichandran S, Brooks SR, Juan AH, Campanario S, Jiang K, Hong X, Ortet L, Ruiz-Bonilla V, Flández M, Moiseeva V, Rebollo E, Jardí M, Sun HW, Musarò A, Sandri M, Del Sol A, Sartorelli V, Muñoz-Cánoves P
        

                    Nat Cell Biol.
        
                    2020 Nov;
        
                    22(11).
        
                    doi: 10.1038/s41556-020-00593-7
                            PMID: 33106654
  A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans.

    Tsai PF, Dell'Orso S, Rodriguez J, Vivanco KO, Ko KD, Jiang K, Juan AH, Sarshad AA, Vian L, Tran M, Wangsa D, Wang AH, Perovanovic J, Anastasakis D, Ralston E, Ried T, Sun HW, Hafner M, Larson DR, Sartorelli V
        

                    Mol Cell.
        
                    2018 Jul 5;
        
                    71(1).
        
                    doi: 10.1016/j.molcel.2018.06.008
                            PMID: 29979962
  Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus.

    Carlucci PM, Purmalek MM, Dey AK, Temesgen-Oyelakin Y, Sakhardande S, Joshi AA, Lerman JB, Fike A, Davis M, Chung JH, Playford MP, Naqi M, Mistry P, Gutierrez-Cruz G, Dell'Orso S, Naz F, Salahuddin T, Natarajan B, Manna Z, Tsai WL, Gupta S, Grayson P, Teague H, Chen MY, Sun HW, Hasni S, Mehta NN, Kaplan MJ
        

                    JCI Insight.
        
                    2018 Apr 19;
        
                    3(8).
        
                    pii: 99276. doi: 10.1172/jci.insight.99276
                            PMID: 29669944
  The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins.

    Wang AH, Juan AH, Ko KD, Tsai PF, Zare H, Dell'Orso S, Sartorelli V
        

                    Mol Cell.
        
                    2017 Oct 19;
        
                    68(2).
        
                    doi: 10.1016/j.molcel.2017.09.016
                            PMID: 29033324
  Laminopathies disrupt epigenomic developmental programs and cell fate.

    Perovanovic J, Dell'Orso S, Gnochi VF, Jaiswal JK, Sartorelli V, Vigouroux C, Mamchaoui K, Mouly V, Bonne G, Hoffman EP
        

                    Sci Transl Med.
        
                    2016 Apr 20;
        
                    8(335).
        
                    doi: 10.1126/scitranslmed.aad4991
                            PMID: 27099177
  The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1.

    Dell'Orso S, Wang AH, Shih HY, Saso K, Berghella L, Gutierrez-Cruz G, Ladurner AG, O'Shea JJ, Sartorelli V, Zare H
        

                    Cell Rep.
        
                    2016 Feb 9;
        
                    14(5).
        
                    doi: 10.1016/j.celrep.2015.12.103
                            PMID: 26832413
  The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells.

    Ryall JG, Dell'Orso S, Derfoul A, Juan A, Zare H, Feng X, Clermont D, Koulnis M, Gutierrez-Cruz G, Fulco M, Sartorelli V
        

                    Cell Stem Cell.
        
                    2015 Feb 5;
        
                    16(2).
        
                    doi: 10.1016/j.stem.2014.12.004
                            PMID: 25600643 
          Education
              
            University of “La Sapienza”, Rome, Italy

Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, NIH             
                        Experience
              
            ChiefGenomic Technology Section, OST, NIAMS, NIH
Senior Staff ScientistGenomic Technology Section, OST, NIAMS, NIH

Research FellowGenomic Technology Section, OST, NIAMS, NIH

Post-doc
Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, NIH


Last Updated: July 2023


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