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          Labs @ NIAMS
          NIAMS Scientific Advances
          Gene Expression Analysis in Single Cells Reveals Considerable Diversity in Human Neutrophils








NIAMS Advances


Gene Expression Analysis in Single Cells Reveals Considerable Diversity in Human Neutrophils July 1, 2022
                                TRANSLATIONAL
        Luis M. Franco, M.D.
                                          |
              Functional Immunogenomics Section
                                          |
              NIAMS IRP
        Description

Neutrophils are a major cell type of the immune system but are notoriously challenging to study. They have often been described as a homogenous cell type but this study challenges that notion by demonstrating that human neutrophils are a heterogenous group of cells with distinct gene expression profiles. This report also describes an improved method to study neutrophils, creating a guideline for future studies of this key cell type.

What is exciting about this article?

Understanding the cells involved in any disease process is an important step to finding treatments for patients. This article increases understanding of neutrophils, an immune cell type that is involved in acute and chronic inflammatory conditions and gives scientists the tools to study them.

How does this fit into the larger NIAMS portfolio?

This article fits in well with the NIAMS profile by improving technology to aid in further understanding of the immune system. The results from this paper will be valuable for future studies aimed at understanding human disease.

Grant support

AR041210
        Research Areas:
            Cell Biology
      Computational Biology
      Genetics and Genomics
      Molecular Pharmacology
                                        CORE Facilities:
            Biodata Mining and Discovery Section
              Genomic Technology Section
                    Reference:
            Single-Cell Analysis Reveals the Range of Transcriptional States of Circulating Human Neutrophils.

    Wigerblad G, Cao Q, Brooks S, Naz F, Gadkari M, Jiang K, Gupta S, O'Neil L, Dell'Orso S, Kaplan MJ, Franco LM
        

                    J Immunol.
        
                    2022 Aug 15;
        
                    209(4).
        
                    doi: 10.4049/jimmunol.2200154
                            PMID: 35858733
        Research reported in this publication was supported by the Intramural Research Program of the NIHʼs National Institute of Arthritis and Musculoskeletal and Skin Diseases.
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