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          NIAMS Scientific Advances
          Macrophages Control Skin Susceptibility to a Common Bacterial Infection








NIAMS Advances


Macrophages Control Skin Susceptibility to a Common Bacterial Infection July 11, 2023
                                BASIC
        Keisuke (Chris) Nagao, M.D., Ph.D.
                                          |
              Cutaneous Leukocyte Biology Section
                                          |
              NIAMS IRP
        DescriptionThe skin consists of the epidermis, dermis, and hypodermis or subcutaneous tissue. The hypodermis is the predominant site of infection, which causes redness, swelling, and pain with potentially serious health problems. How immune cells prevent or promote*S. aureus*infection is unclear. The authors of this study found that hypodermal macrophages (HDMs) enhance tissue clearance of the extracellular matrix component hyaluronic acid, which provides*S. aureus*with an opportunity to hijack the tissue and establish infection. HDMs did so through cell-autonomous insulin-like growth factor 1-driven expression of the hyaluronic acid receptor LYVE-1.What is exciting about this article?The findings show that macrophages and stroma communicate intricately to support skin structural integrity. It also confirms the role of macrophages in the regulation of hyaluronic acid. These functions of hypodermal macrophages may be harnessed to limit skin infection.Grant supportAR041226
        Research Areas:
            Clinical Research
      Computational Biology
      Microbiology and Infectious Diseases
      Skin Biology
      Virology
                                        Reference:
            Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin.

    Voisin B, Nadella V, Doebel T, Goel S, Sakamoto K, Ayush O, Jo JH, Kelly MC, Kobayashi T, Jiang JX, Hu Y, Yan C, Nagao K
        

                    Immunity.
        
                    2023 Jul 11;
        
                    56(7).
        
                    doi: 10.1016/j.immuni.2023.06.006
                            PMID: 37402364
        Research reported in this publication was supported by the Intramural Research Program of the NIHʼs National Institute of Arthritis and Musculoskeletal and Skin Diseases.
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