----

----

|   | [X]  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|--------|---------------------------------------------------------------------------------------------------|

|   | [   ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|--------|----------------------------------------------------------------------------------------------------------------|

|  Delaware                                                                                                                 |   |    59-2758596                      |
|--------------------------------------------------------------------------------------------------------------------------------|--------|---------------------------------------------------|
|  (State or other jurisdiction of incorporation or organization)                                                 |   |    (I.R.S. Employer Identification No.) |
|  354 Eisenhower ParkwayLivingston, New Jersey  (Address of principal executive offices)     |   | 07039(Zip Code)                                   |

----

----

|                                                                                                                                                                          |   | March 31,   |         |   | December 31, |   |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-------------|--------------|--------|--------------|--------|
|                                                                                                                                                                          |   | 2010        |         |   | 2009         |   |
|                                                                                                                                                                          |   | (Unaudited) |         |   |         |   |
| ASSETS                                                                                                                                                                        |   |        |         |   |         |   |
| Current Assets:                                                                                                                                                               |   |        |         |   |         |   |
| Cash and cash equivalents of which $9,220,493 in 2010 and   $12,225,732 in 2009 is interest bearing                                                            |   | $           | 11,284,243   |   |         | $      | 14,757,615 |   |
| Accounts receivable, net of allowances for doubtful accounts    of $100,000 in 2010 and 2009, respectively                                                |   |        | 3,297,668    |   |         |   | 4,262,851 |   |
| Inventories                                                                                                                                                                   |   |        | 3,088,990    |   |         |   | 2,532,722 |   |
| Prepaid expenses and other current assets                                                                                                                                     |   |        | 1,009,323    |   |         |   | 1,097,525 |   |
| Total current assets                                                                                                                                                          |   |        | 18,680,224   |   |         |   | 22,650,713 |   |
|                                                                                                                                                                          |   |        |         |   |         |   |   |   |
| Property and equipment, net                                                                                                                                                   |   |        | 637,812      |   |         |   | 691,479 |   |
| Intangible assets - net                                                                                                                                                       |   |        | 17,509,150   |   |         |   | 18,770,332 |   |
| Other assets                                                                                                                                                                  |   |        | 1,434,024    |   |         |   | 1,644,695 |   |
|                                                                                                                                                                          |   |        |         |   |         |   |   |   |
| TOTAL ASSETS                                                                                                                                                                  |   | $           | 38,261,210   |   |         | $      | 43,757,219 |   |
|                                                                                                                                                                          |   |        |         |   |         |   |   |   |
| LIABILITIES AND SHAREHOLDERS' DEFICIT                                                                                                                                         |   |        |         |   |         |   |   |   |
| Current Liabilities:                                                                                                                                                          |   |        |         |   |         |   |   |   |
| Current portion of financing agreements                                                                                                                                       |   | $           | 58,563       |   |         | $      | 144,897 |   |
| Accounts payable                                                                                                                                                              |   |        | 2,805,472    |   |         |   | 3,662,091 |   |
| Accrued expenses                                                                                                                                                              |   |        | 5,512,142    |   |         |   | 4,588,088 |   |
| Derivative embedded within convertible notes, fair value                                                                                                                      |   |        | 2,781,660    |   |         |   | - |   |
| Total current liabilities                                                                                                                                                     |   |        | 11,157,837   |   |         |   | 8,395,076 |   |
|                                                                                                                                                                          |   |        |         |   |         |   |   |   |
| Notes payable                                                                                                                                                                 |   |        | 33,749,209   |   |         |   | 32,965,863 |   |
| Deferred revenue                                                                                                                                                              |   |        | 312,181      |   |         |   | 328,367 |   |
| Long-term portion of financing agreements                                                                                                                                     |   |        | 15,867,735   |   |         |   | 15,234,406 |   |
| TOTAL LIABILITIES                                                                                                                                                             |   |        | 61,086,962   |   |         |   | 56,923,712 |   |
|                                                                                                                                                                          |   |        |         |   |         |   |   |   |
| COMMITMENTS AND CONTINGENCIES                                                                                                                                                 |   |        |         |   |         |   |   |   |
|                                                                                                                                                                          |   |        |         |   |         |   |   |   |
| Contingently Redeemable Series C Preferred Stock,  600 shares issued and outstanding in 2010 and 2009, respectively  (liquidation preference of $600,000) |   |        | 600,000      |   |         |   | 600,000 |   |
|                                                                                                                                                                          |   |        |         |   |         |   |   |   |
| SHAREHOLDERS' DEFICIT:                                                                                                                                                        |   |        |         |   |         |   |   |   |
| Preferred stock, $.01 par value;1,000,000 shares authorized                                                                                                                   |   |        |         |   |         |   |   |   |
| Series B Convertible Preferred Stock, 130 shares issued and   outstanding (liquidation preference of $13,000)                                                  |   |        | 1            |   |         |   | 1 |   |
| Series E Convertible Preferred Stock, 59,000 shares issued and   outstanding (liquidation preference of $5,900,000)                                            |   |        | 590          |   |         |   | 590 |   |
| Common Stock $.01 par value; 100,000,000 shares   authorized; 65,761,986 shares issued in 2010 and 2009,   respectively                         |   |        | 657,619      |   |         |   | 657,619 |   |
| Capital in excess of par value                                                                                                                                                |   |        | 243,191,797  |   |         |   | 242,637,646 |   |
| Less cost of 152,795 and 131,935 treasury shares in     2010 and 2009, respectively                                                                  |   |        | (306,369     | )      |         |   | (280,813 | ) |
| Accumulated deficit                                                                                                                                                           |   |        | (267,158,299 | )      |         |   | (256,979,263 | ) |
| Accumulated other comprehensive income                                                                                                                                        |   |        | 188,909      |   |         |   | 197,727 |   |
| Shareholders' deficit                                                                                                                                                         |   |        | (23,425,752  | )      |         |   | (13,766,493 | ) |
| TOTAL LIABILITIES AND SHAREHOLDERS' DEFICIT                                                                                                                                   |   | $           | 38,261,210   |   |         | $      | 43,757,219 |   |

----

|                                                       |   | Three Months Ended March 31, |
|------------------------------------------------------------|--------|------------------------------|
|                                                       |   | 2010                         |   |   | 2009 |   |
|                                                       |   |                         |   |   |   |   |
| NET REVENUES                                               |   | $                            | 7,172,899 |   |   | $ | 7,321,187 |   |
|                                                       |   |                         |   |   |   |   |   |   |
| COST OF REVENUES                                           |   |                         | 1,176,579 |   |   |   | 1,780,018 |   |
| Gross profit                                               |   |                         | 5,996,320 |   |   |   | 5,541,169 |   |
|                                                       |   |                         |   |   |   |   |   |   |
| OPERATING EXPENSES:                                        |   |                         |   |   |   |   |   |   |
| Selling and distribution                                   |   |                         | 3,250,319 |   |   |   | 2,793,236 |   |
| General and administrative                                 |   |                         | 4,126,318 |   |   |   | 2,488,553 |   |
| Research and development                                   |   |                         | 2,341,818 |   |   |   | 2,245,385 |   |
| Amortization of licensing right                            |   |                         | 1,261,182 |   |   |   | 1,261,182 |   |
| Total operating expenses                                   |   |                         | 10,979,637 |   |   |   | 8,788,356 |   |
|                                                       |   |                         |   |   |   |   |   |   |
| Loss from operations                                       |   |                         | (4,983,317 | ) |   |   | (3,247,187 | ) |
|                                                       |   |                         |   |   |   |   |   |   |
| OTHER INCOME (EXPENSES):                                   |   |                         |   |   |   |   |   |   |
| Interest income                                            |   |                         | 1,620 |   |   |   | 19,197 |   |
| Interest expense                                           |   |                         | (2,302,794 | ) |   |   | (2,048,101 | ) |
| Change in fair value of derivative                         |   |                         | (2,781,660 | ) |   |   | - |   |
| Other, net                                                 |   |                         | (110,685 | ) |   |   | (40,546 | ) |
| Total other expenses                                       |   |                         | (5,193,519 | ) |   |   | (2,069,450 | ) |
|                                                       |   |                         |   |   |   |   |   |   |
| Loss before taxes                                          |   |                         | (10,176,836 | ) |   |   | (5,316,637 | ) |
| State income taxes                                         |   |                         | (2,200 | ) |   |   | (16,930 | ) |
| NET LOSS                                                   |   | $                            | (10,179,036 | ) |   | $ | (5,333,567 | ) |
|                                                       |   |                         |   |   |   |   |   |   |
| NET LOSS PER COMMON SHARE:                                 |   |                         |   |   |   |   |   |   |
| Basic and diluted                                          |   | $                            | (0.16 | ) |   | $ | (0.10 | ) |
|                                                       |   |                         |   |   |   |   |   |   |
| WEIGHTED AVERAGE NUMBER OF COMMON SHARES OUTSTANDING: |
| Basic and diluted                                          |   |                         | 65,388,921 |   |   |   | 54,296,686 |   |

----

|                               |                         |                 |                 | Three Months Ended |
|------------------------------------|------------------------------|----------------------|----------------------|--------------------|
|                               |                         |                 |                 | March 31,          |
|                               |                         |                 |                 | 2010               |   | 2009 |
|                               |                         |                 |                 |               |   |   |
| NET LOSS                           |                         |                 |  $ (10,179,036) |               |  $(5,333,567) |
|                               |                         |                 |                 |               |   |   |
| Other comprehensive income (loss): |                         |                 |                 |               |
|                               | Foreign currency translation |                 | (8,818)              |               | 12,633 |
|                               |                         |                 |                 |               |   |   |
| COMPREHENSIVE LOSS                 |                         |  $ (10,187,854) |                 |  $(5,320,934) |

----

|                                                |   | Three Months Ended March 31, |
|-----------------------------------------------------|--------|------------------------------|
|                                                |   | 2010                         |   |   | 2009 |
| CASH FLOWS FROM OPERATING ACTIVITIES:               |   |                         |   |   |   |
| Net loss                                            |   | $                            | (10,179,036 | ) |   | $ | (5,333,567) |
| Adjustments to reconcile net loss to net            |   |                         |   |   |   |   |   |
| cash used in operating activities-                  |   |                         |   |   |   |   |   |
| Depreciation and amortization                       |   |                         | 1,526,916 |   |   |   | 1,385,300 |
| Amortization on beneficial conversion features      |   |                         | 451,490 |   |   |   | 393,688 |
| Amortization on warrant valuation                   |   |                         | 331,857 |   |   |   | 294,219 |
| Change in fair value of derivative                  |   |                         | 2,781,660 |   |   |   | - |
| Provision for sales returns                         |   |                         | 1,063,993 |   |   |   | 404,027 |
| Writedown of inventories                            |   |                         | 14,001 |   |   |   | - |
| Stock based compensation                            |   |                         | 561,651 |   |   |   | 456,757 |
| Non-cash interest expense on financing agreements   |   |                         | 546,995 |   |   |   | 444,263 |
| Changes in assets and liabilities-                  |   |                         |   |   |   |   |   |
| (Increase) decrease in:                             |   |                         |   |   |   |   |   |
| Accounts receivable                                 |   |                         | 965,183 |   |   |   | (527,486) |
| Inventories                                         |   |                         | (570,269 | ) |   |   | (637,570) |
| Prepaid expenses and other current assets           |   |                         | 88,202 |   |   |   | (15,087) |
| Other assets                                        |   |                         | (183 | ) |   |   | (2,711) |
|  Increase (decrease) in:                       |   |                         |   |   |   |   |   |
| Accounts payable                                    |   |                         | (856,619 | ) |   |   | 211,125 |
| Accrued expenses                                    |   |                         | (133,833 | ) |   |   | (281,822) |
| Deferred revenue                                    |   |                         | (16,186 | ) |   |   | (12,733) |
| Net cash used in operating activities               |   |                         | (3,424,178 | ) |   |   | (3,221,597) |
|                                                |   |                         |   |   |   |   |   |
| CASH FLOWS FROM INVESTING ACTIVITIES:               |   |                         |   |   |   |   |   |
| Purchase of property and equipment                  |   |                         | (1,214 | ) |   |   | (4,946) |
| Net cash used in investing activities               |   |                         | (1,214 | ) |   |   | (4,946) |
|                                                |   |                         |   |   |   |   |   |
| CASH FLOWS FROM FINANCING ACTIVITIES:               |   |                         |   |   |   |   |   |
| Net proceeds from the sale of common stock          |   |                         | - |   |   |   | 750,000 |
| Proceeds from exercise of options                   |   |                         | - |   |   |   | - |
| Payments for purchase of treasury stock             |   |                         | (25,556 | ) |   |   | (23,389) |
| Payments pursuant to financing agreements           |   |                         | - |   |   |   | - |
| Dividends paid                                      |   |                         | (7,500 | ) |   |   | (9,688) |
| Net cash provided by (used in) financing activities |   |                         | (33,056 | ) |   |   | 716,923 |
|                                                |   |                         |   |   |   |   |   |

----

|                                    |   |    Three Months Ended March 31, |
|-----------------------------------------|--------|------------------------------------------------|
|                                    |   | 2010                                           |   |   | 2009 |   |
|                                    |   |                                           |   |   |   |   |
| EFFECT OF EXCHANGE RATE CHANGES ON CASH |   |                                           | (14,924 | ) |   |   | (35,368 | ) |
|                                    |   |                                           |   |   |   |   |   |   |
| NET DECREASE IN CASH                    |   |                                           | (3,473,372 | ) |   |   | (2,544,988 | ) |
|                                    |   |                                           |   |   |   |   |   |   |
| CASH, BEGINNING OF PERIOD               |   |                                           | 14,757,615 |   |   |   | 12,497,382 |   |
|                                    |   |                                           |   |   |   |   |   |   |
| CASH END OF PERIOD                      |   | $                                              | 11,284,243 |   |   | $ | 9,952,394 |   |
|                                    |   |                                           |   |   |   |   |   |   |
|                                    |   |                                           |   |   |   |   |   |   |
| SUPPLEMENTAL INFORMATION                |   |                                           |   |   |   |   |   |   |
|                                    |   |                                           |   |   |   |   |   |   |
| Interest paid                           |   | $                                              | 800,000 |   |   | $ | 800,001 |   |
|                                    |   |                                           |   |   |   |   |   |   |
| Taxes paid                              |   | $                                              | 8,500 |   |   | $ | 31,617 |   |
|                                    |   |                                           |   |   |   |   |   |   |
|                                    |   |                                           |   |   |   |   |   |   |
|                                    |   |                                           |   |   |   |   |   |   |
|                                    |   |                                           |   |   |   |   |   |   |
|                                    |   |                                           |   |   |   |   |   |   |
|                                    |   |                                           |   |   |   |   |   |   |

----

| (1)         | SIGNIFICANT ACCOUNTING POLICIES: |
|-----------------------------------------------------|----------------------------------|

| (2)         | SALES RETURN RESERVES: |
|-----------------------------------------------------|------------------------|

|                            | Three Months Ended March 31,                                                    |
|---------------------------------|---------------------------------------------------------------------------------|
|                            | 2010                                                                            |   | 2009 |
|                            |                                                                            |   |   |
| Balance at beginning of year    |  $     1,883,623                                  |   |  $   1,864,316 |
|                            |                                                                            |   |   |
| Provision:                      |                                                                            |   |   |
| Related to current period sales | 319,078                                                                         |   | 154,027 |
| Related to prior period sales   |           744,915             |   | 250,000 |
|                            |        1,063,993                             |   | 404,027 |
|                            |                                                                            |   |   |
| Returns:                        |                                                                            |   |   |
| Related to current period sales |             (7,879) |   |           (6,845) |
| Related to prior period sales   |         (332,770)                       |   |        (538,498) |
|                            |         (340,649)                       |   |        (545,343) |
|                            |                                                                            |   |   |
| Balance at end of quarter       |  $     2,606,967                                  |   |  $   1,723,000 |

----

| (3)         | INVENTORIES: |
|-----------------------------------------------------|--------------|

|           |   | March 31,                    |   | December 31,                       |
|----------------|--------|------------------------------|--------|------------------------------------|
|           |   | 2010                         |   | 2009                               |
| Finished goods |   |  $  2,058,683 |   |  $   1,343,742 |
| Raw materials  |   | 1,030,307                    |   | 1,188,980                          |
|           |   |                         |   |                               |
|           |   |  $  3,088,990 |   |  $   2,532,722 |

| (4)         | FINANCING AGREEMENTS: |
|-----------------------------------------------------|-----------------------|

|                  |                                                                                       | March 31,                                       |                                                          |  December 31,            |
|-----------------------|--------------------------------------------------------------------------------------------|-------------------------------------------------|---------------------------------------------------------------|-------------------------------|
|                  |                                                                                       | 2010                                            |                                                          | 2009                          |
| STRIANT Agreement     |  $     15,926,298                                            |                                            |  $  15,379,303                                 |
| Less: current portion |               58,563 |                                            |          144,897 |
|                  |                                                                                       |  $     15,867,735 |                                                          |  $  15,234,406 |

| (5)         | NOTES PAYABLE: |
|-----------------------------------------------------|----------------|

----

| (6)         | GEOGRAPHIC INFORMATION: |
|-----------------------------------------------------|-------------------------|

|                           |                |                                                                                              | Net                          |                                                                                              | Identifiable       |
|--------------------------------|---------------------|---------------------------------------------------------------------------------------------------|------------------------------|---------------------------------------------------------------------------------------------------|--------------------|
|                           |                |                                                                                              | Revenues                     |                                                                                              | Assets             |
|                           |                |                                                                                              |                         |                                                                                              |               |
| As of and for the three months |                |                                                                                              |                         |
| ended March 31, 2010           |                |                                                                                              |                         |
|                           | United States       |  $  4,649,037                                                                      |                         |  $ 32,586,890                                                                                |
|                           |                |                                                                                              |                         |                                                                                              |               |
|                           | Switzerland         |      2,363,620                                                           |                         |      5,674,320                                                           |
|                           | Other countries     |         160,242                                           |                         |                 - |
|                           | Total International |      2,523,862                                                           |                         |      5,674,320                                                           |
|                           | Total               |                                                                                              |  $  7,172,899 |                                                                                              |  $ 38,261,210 |
|                           |                |                                                                                              |                         |                                                                                              |               |
| As of and for the three months |                |                                                                                              |                         |
| ended March 31, 2009           |                |                                                                                              |                         |
|                           | United States       |  $  5,157,187                                                                      |                         |  $ 35,458,261                                                                                |
|                           |                |                                                                                              |                         |                                                                                              |               |
|                           | Switzerland         |      2,164,000                                                           |                         |      7,421,740                                                           |
|                           | Other countries     |                 - |                         |                 - |
|                           | Total International |      2,164,000                                                           |                         |      7,421,740                                                           |
|                           | Total               |                                                                                              |  $  7,321,187 |                                                                                              |  $ 42,880,001 |

| (7)         | LOSS PER COMMON AND POTENTIAL COMMON SHARE: |
|-----------------------------------------------------|---------------------------------------------|

|                   |                                              |                                                                      | Three Months Ended |
|------------------------|---------------------------------------------------|---------------------------------------------------------------------------|--------------------|
|                   |                                              |                                                                      | March 31,          |
|                   |                                              |                                                                      | 2010               |   | 2009 |
|                   |                                              |                                                                      |               |   |   |
| Net loss               |                                              |  $ (10,179,036)                                                      |               |  $(5,333,567) |
|                   | Less: Preferred stock dividends                   | (7,500)                                                                   |               | (9,688) |
|                   |                                              |                                                                      |               |   |   |
| Net loss applicable to |                                              |                                                                      |               |
|                   | common stock                                      |  $ (10,186,536)                                                      |               |  $(5,343,255) |
|                   |                                              |                                                                      |               |   |   |
| Basic and diluted:     |                                              |                                                                      |               |
|                   | Weighted average number of                        |                                                                      |               |   |
|                   |     common shares outstanding |      65,388,921                                  |               |    54,296,686 |
|                   |                                              |                                                                      |               |   |   |
|                   | Basic and diluted net loss per common share       |  $          (0.16) |               |  $        (0.10) |

| (8)         | LEGAL PROCEEDINGS: |
|-----------------------------------------------------|--------------------|

----

| (9)         | STOCK-BASED COMPENSATION: |
|-----------------------------------------------------|---------------------------|

|                       |   | Three Months Ended March 31,                                                         |
|----------------------------|--------|--------------------------------------------------------------------------------------|
| Stock Based Compensation   |   | 2010                                                                                 |   | 2009 |
|                       |   |                                                                                 |   |   |
| Cost of revenues           |   |  $           23,234      |   |  $          32,492 |
|                       |   |                                                                                 |   |   |
| Selling and distribution   |   |             231,290      |   |              92,003 |
|                       |   |                                                                                 |   |   |
| General and administrative |   |             264,211      |   |            295,197 |
|                       |   |                                                                                 |   |   |
| Research and development   |   |              42,916 |   |              37,065 |
|                       |   |                                                                                 |   |   |
| Total                      |   |  $         561,651                 |   |  $        456,757 |

| (10)              | FAIR VALUE OF FINANCIAL INSTRUMENT |
|------------------------------------------------------------------------------------|------------------------------------|

| (11)              | RECENT ACCOUNTING PRONOUNCEMENTS: |
|------------------------------------------------------------------------------------|-----------------------------------|

----

| (12)              | WATSON TRANSACTION AND DEBT RESTRUCTURING |
|------------------------------------------------------------------------------------|-------------------------------------------|

----

| (13)             | SUBSEQUENT EVENTS |
|------------------------------------------------------------------------------|-------------------|

----

|                  |   | Products                                                                                                                                                                                                                                                                                                                                                                                                                                     |
|-----------------------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                  |   |                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| Progesterone Products |   |  CRINONE® 8% (progesterone gel) marketed and sold by us in the U.S.  CRINONE® 8% sold to Merck Serono for resale outside the U.S.  PROCHIEVE® 8% (progesterone gel) sold by us in the U.S.  PROCHIEVE® 4% sold to Ascend Therapeutics, Inc., for resale in the U.S., pursuant to an    agreement that will terminate on July 23, 2010. |
|                  |   |                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| Other Products        |   |  STRIANT® (testosterone buccal system) marketed and sold by us in the U.S.  STRIANT® sold to Mipharm, S.p.A. for resale in Italy.  Royalty and licensing revenues.                                                                                                                                                                                                           |

|                 | Three Months Ended                                            |
|----------------------|---------------------------------------------------------------|
|                 | March 31,                                                     |
|                 | 2010                                                          |   | 2009 |
| Cash flows:          |                                                          |   |   |
| Operating activities |  $(3,334,178)                                            |   |  $(3,221,597) |
| Investing activities |          (1,214) |   |          (4,946) |
| Financing activities |        (33,056)            |   |        716,923 |

----

|                    | Three Months Ended |
|-------------------------|--------------------|
|                    | March 31,          |
|                    | 2010               | 2009 |
| Risk free interest rate |  -            | 1.78% |
| Expected term           |  -            | 4.6 years |
| Dividend yield          |  -            | 0 |
| Expected volatility     |  -            | 0.9295 |

|   | None. |
|--------|-------|

| (a)   | Exhibits |
|-----------------|----------|

| 2.1          | Purchase and Collaboration Agreement, dated as of March 3, 2010, by and among Columbia Laboratories, Inc., Watson Pharmaceuticals, Inc. and Coventry Acquisition, Inc. (1)                                                                                                                            |
|--------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 10.1         | Note Purchase and Amendment Agreements, each dated as of March 3, 2010, between Columbia Laboratories, Inc. and the Holders named therein (1)                                                                                                                                                              |
| 10.2         | Amendment No. 1, dated as of March 3, 2010, to the Company’s Convertible Subordinated Notes due December 31, 2011 (1)                                                                                                                                                                 |
| 10.3         | Letter Agreement, dated March 3, 2010, between Columbia Laboratories, Inc. and PharmaBio Development Inc., relating to the Investment and Royalty Agreement, dated March 5, 2003, between Columbia Laboratories, Inc. and PharmaBio Development Inc., as previously amended and supplemented (1) |
| 10.4 † | Amended and Restated Employment Agreement by and between Columbia Laboratories, Inc. and Frank C. Condella, Jr., dated May 4, 2010. (2)                                                                                                                                                               |
| 31.1         | Rule 13a-14(a)/15d-14(a) Certification of Chief Executive Officer of the Company.*                                                                                                                                                                                                                         |
| 31.2         | Rule 13a-14(a)/15d-14(a) Certification of Chief Financial Officer of the Company.*                                                                                                                                                                                                                         |
| 32.1         | Certification Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.*                                                                                                                                                                                   |
| 32.2         | Certification Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.*                                                                                                                                                                                   |

|   | * | Filed herewith. |
|--------|---|-----------------|

|   | † | Management contract or compensatory plans or arrangements |
|--------|---------|-----------------------------------------------------------|

|   | (1) | Incorporated by reference to the Registrant’s Current Report on Form 8-K, dated March 4, 2010 |
|--------|-----|-----------------------------------------------------------------------------------------------------|

|   | (2) | Incorporated by reference to the Registrant’s Current Report on Form 8-K, dated May 4, 2010 |
|--------|-----|---------------------------------------------------------------------------------------------------|

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|   |   |
|--------|--------|

|   | SIGNATURES |
|--------|------------|