An official website of the United States government
          Here’s how you know
        Here’s how you know**Official websites use .gov**A
              **.gov** website belongs to an official government
              organization in the United States.
        **Secure .gov websites use HTTPS**A
              **lock** (
              Locked padlock icon) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
 Top Utility Nav
        
        
        Asian-Language Resources
        
        Portal en español


Site search Mega Menu
  

        

        Home
                  Health Topics
                                      
    
  Health Topics

    Arthritis and Rheumatic Diseases
          
    Muscle and Bone Diseases
          
    Skin Diseases
          
    All Diseases and Conditions
          
    Publication Catalog
                  Grants & Funding
                                      
    
  Grants & Funding

    Current Funding Opportunities
          
    Supported Scientific Programs
          
    NIAMS-Supported Programs
          
    Applying for a Grant
          
    NIH Policies and Guidance
          
    Peer Review and Grants Administration Resources
          
    Types of Funding Mechanisms (Activity Codes)
                  Labs @ NIAMS
                                      
    
  Labs @ NIAMS

    NIAMS Labs and Core Facilities
          
    Research Faculty
          
    Research Areas
          
    NIAMS Scientific Advances
          
    Training and Career Development
                  Clinical Trials
                                      
    
  Clinical Trials
      
            For Principal Investigators

    Clinical Trial Policies, Guidelines, and Templates
          
    Conducting Clinical Trials
          
    Register with ClinicalTrials.gov

For Patients

What is a Clinical Trial?
	Clinical Trials at NIAMS
	Clinical Trials in the Spotlight
                  News & Events
                                      
    
  Newsroom

    All NIAMS News
          
    NIAMS Newsletters
          
    Meetings & Events
                  About NIAMS
                                      
    
  About NIAMS

    Director's Page
          
    NIAMS Organization
          
    Strategic Plan Fiscal Years 2020-2024
          
    Staff Directory
          
    NIAMS Budget
          
    Partnerships
          
    Contact NIAMS
                  Community Outreach
                                      
    
  Community Outreach

    Bone Health
          
    Joint Health
          
    Muscle, Tendon, and Ligament Health
          
    Skin Health
          
    Health Information For Kids And Young Adults
          
    Health Information For Older Adults/Seniors
          
    Printable Materials for Community Events
          
    Resources in Other Languages
          
    Annual Health Observances
          
    Social Media Resources Breadcrumb
    Home
          About NIAMS
          Mamduh Khateb, Ph.D.





Mamduh Khateb, Ph.D.


Research Fellow
    Laboratory of Muscle Stem Cells and Gene Regulation Photo of Mamduh Khateb 
            Contact Information

                                                  301-435-3095
                
                                                9000 Rockville Pike
                  
                  
            Building 50, Room 1347
      
                                   Bethesda MD 20892
                
                                                mamduh.khateb@nih.gov 
                Summary
          Dr. Mamduh Khateb is a postdoctoral fellow in the Laboratory of Muscle Stem Cells & Gene Regulation at NIAMS (NIH). Before his current postdoctoral fellowship at the NIH, he completed postdoctoral research in embryonic stem cells and gene regulation at the Technion-Israel Institute of Technology. Dr. Khateb finished his Ph.D. studies in the Technion, where he became interested in investigating the gene regulation during hematopoiesis lineage. In particular, he focused on the Interferon Regulatory Factor 8 (IRF8) gene that plays an important role in monocytes, macrophages, and dendritic cell generation. During his Ph.D. studies, Dr. Khateb was an assistant teacher for students in undergraduate studies.
        
                  Research Statement
          
            Cell fate specification is a key process enabling the formation of multicellular organisms. Totipotent embryonic stem cells (ESC) remodel their epigenome to acquire particular cell fates and form different tissues. The transitions of the epigenetic landscape accompanying the acquisition of the myogenic lineage starting from ESC are largely unknown. I am interested in defining the epigenetic changes occurring during myogenic lineage specification and providing insight into molecular mechanisms of early muscle fate acquisition. More specifically, I am interested in identifying the regulatory element(s) regulating the Muscle Stem Cells (MuSC) regulator, PAX7. 

            Scientific Publications
              The Third Intron of IRF8 Is a Cell-Type-Specific Chromatin Priming Element during Mouse Embryonal Stem Cell Differentiation.

    Khateb M, Azriel A, Levi BZ
        

                    J Mol Biol.
        
                    2019 Jan 18;
        
                    431(2).
        
                    doi: 10.1016/j.jmb.2018.11.022
                            PMID: 30502383
  The Third Intron of the Interferon Regulatory Factor-8 Is an Initiator of Repressed Chromatin Restricting Its Expression in Non-Immune Cells.

    Khateb M, Fourier N, Barnea-Yizhar O, Ram S, Kovalev E, Azriel A, Rand U, Nakayama M, Hauser H, Gepstein L, Levi BZ
        

                    PLoS One.
        
                    2016;
        
                    11(6).
        
                    doi: 10.1371/journal.pone.0156812
                            PMID: 27257682
  Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism.

    Khateb M, Ruimi N, Khamisie H, Najajreh Y, Mian A, Metodieva A, Ruthardt M, Mahajna J
        

                    BMC Cancer.
        
                    2012 Nov 27;
        
                    12().
        
                    doi: 10.1186/1471-2407-12-563
                            PMID: 23186157
  Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I.

    Mian AA, Metodieva A, Badura S, Khateb M, Ruimi N, Najajreh Y, Ottmann OG, Mahajna J, Ruthardt M
        

                    BMC Cancer.
        
                    2012 Sep 17;
        
                    12().
        
                    doi: 10.1186/1471-2407-12-411
                            PMID: 22985168


Last Updated: October 2022


Back to Top
 About NIAMS
                    Clinical Trials
                    Grants & Funding
                    Health Topics
                    Labs @ NIAMS
              News Room
                    NIAMS Multimedia Library
                    Disclaimer
                    FOIA
                    Contact us
              Privacy Statement
                    Accessibility
                    HHS Vulnerability Disclosure
                    Social Media Moderation Policy
                    NIAMS Archives
        Subscribe to Our E-Newsletters
            Click the button to see different options to sign up for newsletters.
            Click Here to Subscribe
          Follow us on
  
  About NIH
                  Accessibility Support
            FOIA requests
                  No FEAR Act data
            Office of the Inspector General
                  Performance reports
            Privacy Policy