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          NIAMS Scientific Advances
          Early Treatment Helps Reduce Long-Term Complications in Children with Job’s Syndrome








NIAMS Advances


Early Treatment Helps Reduce Long-Term Complications in Children with Job’s Syndrome September 6, 2023
                                CLINICAL
        Heidi H. Kong, M.D., M.H.Sc.
                                          |
              Cutaneous Microbiome and Inflammation Section
                                          |
              NIAMS IRP
        DescriptionThis study is a retrospective review of 18 children with STAT3 dominant negative disease (Job’s syndrome) to examine the different treatments and disease manifestation in those with and without a family history of the disease. Children with a family history had an earlier diagnosis and earlier initiation of prophylactic approaches with significantly reduced infection, hospitalization, and surgery rates, as compared to those without.What is exciting about this article?Earlier diagnosis in children with STAT3 dominant negative disease results in earlier interventions, which is linked to less severe disease. Thus, it is important to diagnose these children as early as possible to improve clinical outcomes.Grant supportAR041217
        Research Areas:
            Clinical Research
      Computational Biology
      Genetics and Genomics
      Microbiology and Infectious Diseases
      Skin Biology
                                        Reference:
            Early intervention in STAT3 dominant negative disease.

    An ZA, Williams KW, Urban A, Ali S, Roy S, Lafeer C, Heimall J, Dimitriades VR, Davis J, Kong HH, Cowen EW, Holland SM, Freeman AF
        

                    J Allergy Clin Immunol Pract.
        
                    2023 Dec;
        
                    11(12).
        
                    doi: 10.1016/j.jaip.2023.08.044
                            PMID: 37683824
        Research reported in this publication was supported by the Intramural Research Program of the NIHʼs National Institute of Arthritis and Musculoskeletal and Skin Diseases.
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