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## Overview

Timothy Bhattacharyya, M.D.

bhattacharyyat@mail.nih.gov

#### Research Areas (IRP Lab Groups)

Cell Biology

Epidemiology

Genetics and Genomics

Molecular Biology and Biochemistry

Stem Cell Biology

The Clinical and Investigative Orthopedics Surgery Unit conducts clinical research in the field of Orthopedic Surgery with an emphasis on studying questions that are important to today’s practicing clinicians, such as the choice of nails over plates for certain fractures, or the effect of surgical volume on patient outcomes.

The overarching goal of the unit is to conduct research that improves patient care by identifying the treatments that lead to better outcomes or elucidates the pathophysiological mechanisms of disease.

The program functions on two tracks. The first takes advantage of large clinical databases to perform epidemiological studies and health services research regarding musculoskeletal conditions. The second track engages the resources of the Clinical Center to perform prospective human clinical studies.

Dr. Bhattacharyya is coordinating a multidisciplinary group investigating the rare bone disease melorheostosis. Research spans the spectrum from seeing patients to genetics to developing cellular models. Two somatic mutations have been identified that cause melorheostosis.

#### Scientific Advances

September 22, 2023

Possible Mechanism of a Rare Bone Overgrowth Disease Identified

#### Core Research Facilities

Labs at the NIAMS are supported by the following state-of-the-art facilities and services:
                                        - Biodata Mining and Discovery
                                        - Flow Cytometry
                                        - Genomic Technology
                                        - Laboratory Animal Care and Use
                                        - Light Imaging
                                        - Translational Immunology

## Staff

**Timothy Bhattacharyya, M.D.**

bhattacharyyat@mail.nih.gov

**Jyotirindra Maity, Ph.D.**

jyotirindra.maity@nih.gov

**Amit Patel, B.S.**

amit.patel2@nih.gov

## Image & Media Gallery

##### Melorheostosis

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## Clinical Trials

Recruiting

### Study of the Natural History, Pathogenesis and Outcome of Melorheostosis - a Rare Osteosclerotic Disease

ClinicalTrials.gov Identifier: NCT02504879

The rare disease melorheostosis causes bones to thicken. This may lead to pain, and can affect bones, joints, and muscles. Researchers want to learn more about the disease and how it progresses.

## Scientific Publications

## Selected Recent Publications

###             Better Mobility Is Associated With Higher Incomes and Longer Working Years Among Older Adults.        

482(1).

###             Bone health is improving over time: data from Framingham cohorts.        

18(1).

###             VEGF Secretion Drives Bone Formation in Classical MAP2K1+ Melorheostosis.        

38(12).

###             Reverse engineering the FRAX algorithm: Clinical insights and systematic analysis of fracture risk.        

159().

###             Fibroblasts from Patients with Melorheostosis Promote Angiogenesis in Healthy Endothelial Cells through Secreted Factors.        

142(9).

###             Somatic activating mutations in MAP2K1 cause melorheostosis.        

9(1).

###             Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway.        

217(5).

###             Incidence of Hip Fracture Over 4 Decades in the Framingham Heart Study.        

180(9).

###             Trend Toward High-Volume Hospitals and the Influence on Complications in Knee and Hip Arthroplasty.        

98(9).

###             Trends in Media Reports, Oral Bisphosphonate Prescriptions, and Hip Fractures 1996-2012: An Ecological Analysis.        

30(12).

###             Compliance with Surgical Care Improvement Project measures and hospital-associated infections following hip arthroplasty.        

94(15).

## News & Highlights

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