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          About NIAMS
          Yuka Kanno, M.D., Ph.D.





Yuka Kanno, M.D., Ph.D.


Staff Scientist
    Molecular Immunology and Inflammation Branch Portrait of Yuka Kanno. 
            Contact Information

                                                  301-402-3008
                
                                                9000 Rockville Pike
                  
            10 Center Drive
      
                  
            Building 10, Room 13C120
      
                                   Bethesda MD 20892
                
                                                kannoy@mail.nih.gov 
                                          Media Resources
                                  
            High Resolution Image 
                Summary
          Dr. Yuka Kanno’s primary research interest has been the regulation of gene expression by transcription factors. Using JAK-STAT signaling pathway as a model system, she has profiled genome-wide chromatin conformation and gene transcription following STAT activation in immune cells.
        
                  Research Statement
          
            Dr. Kanno hopes to understand cell-type specific genomic organization that regulated gene transcription during normal and pathological immune responses, and how extracellular signals influence epigenetic information built in chromatin of immune cells. 

            Scientific Publications
              Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality.

    Shih HY, Sciumè G, Mikami Y, Guo L, Sun HW, Brooks SR, Urban JF Jr, Davis FP, Kanno Y, O'Shea JJ
        

                    Cell.
        
                    2016 May 19;
        
                    165(5).
        
                    doi: 10.1016/j.cell.2016.04.029
                            PMID: 27156451
  Super-enhancers delineate disease-associated regulatory nodes in T cells.

    Vahedi G, Kanno Y, Furumoto Y, Jiang K, Parker SC, Erdos MR, Davis SR, Roychoudhuri R, Restifo NP, Gadina M, Tang Z, Ruan Y, Collins FS, Sartorelli V, O'Shea JJ
        

                    Nature.
        
                    2015 Apr 23;
        
                    520(7548).
        
                    doi: 10.1038/nature14154
                            PMID: 25686607
  BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones.

    Kanno T, Kanno Y, LeRoy G, Campos E, Sun HW, Brooks SR, Vahedi G, Heightman TD, Garcia BA, Reinberg D, Siebenlist U, O'Shea JJ, Ozato K
        

                    Nat Struct Mol Biol.
        
                    2014 Dec;
        
                    21(12).
        
                    doi: 10.1038/nsmb.2912
                            PMID: 25383670
  BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.

    Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff CA, Bonelli M, Sciumè G, Zare H, Vahedi G, Dema B, Yu Z, Liu H, Takahashi H, Rao M, Muranski P, Crompton JG, Punkosdy G, Bedognetti D, Wang E, Hoffmann V, Rivera J, Marincola FM, Nakamura A, Sartorelli V, Kanno Y, Gattinoni L, Muto A, Igarashi K, O'Shea JJ, Restifo NP
        

                    Nature.
        
                    2013 Jun 27;
        
                    498(7455).
        
                    doi: 10.1038/nature12199
                            PMID: 23728300
  STATs shape the active enhancer landscape of T cell populations.

    Vahedi G, Takahashi H, Nakayamada S, Sun HW, Sartorelli V, Kanno Y, O'Shea JJ
        

                    Cell.
        
                    2012 Nov 21;
        
                    151(5).
        
                    doi: 10.1016/j.cell.2012.09.044
                            PMID: 23178119
  Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.

    Kanno Y, Vahedi G, Hirahara K, Singleton K, O'Shea JJ
        

                    Annu Rev Immunol.
        
                    2012;
        
                    30().
        
                    doi: 10.1146/annurev-immunol-020711-075058
                            PMID: 22224760 
          Education
              
            **Tohoku University School of Medicine, Sendai, Japan**
M.D./Ph.D.             
                        Experience
              
            **Resident**
NTT Tohoku Hospital, Sendai, Japan

**Postdoctoral Fellow**
Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, NIH

**Instructor**
Institute for Virus Research, Kyoto University, Kyoto, Japan


Last Updated: February 2023


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