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                    Endocrine Diseases & Metabolic Diseases

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        Diabetes
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        Accelerating Medicines Partnership® Program for Type 2 Diabetes (AMP T2D)
                Blood Glucose Control Studies for Type 1 Diabetes: DCCT & EDIC
                Diabetes Prevention Program (DPP)
                Type 1 Diabetes Special Statutory Funding Program
                Digestive Diseases
                Endocrine Diseases & Metabolic Diseases
                Hematologic Diseases
                Kidney Disease
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        Chronic Kidney Disease in Children Study: CKiD
                Effects of Chronic Kidney Disease in Adults Study: CRIC
                Liver Disease
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        Treatments for Fatty Liver Disease (NASH) Study: PIVENS
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        Bariatric Surgery for Teens with Severe Obesity Study: Teen-LABS
                Long-term Study of Bariatric Surgery for Obesity: LABS
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                Urologic Diseases
                Research CentersEndocrine Diseases & Metabolic Diseases
Endocrine Disease & Metabolic DiseaseEndocrine and metabolic diseases span a vast range of conditions. Together, they affect many millions of Americans and can profoundly decrease quality of life. NIDDK supports research on many of these conditions, including osteoporosis, cystic fibrosis, hypothyroidism, and obesity. Osteoporosis is a disease marked by reduced bone strength and linked to aging and fracture risk. 53 million people in the United States either have or are at risk for osteoporosis. Hypothyroidism, or underactive thyroid, affects about 4.6 percent of the U.S. population age 12 and older. More than 30,000 Americans have cystic fibrosis, an inherited disease in which salt and water cannot flow appropriately in many critical tissues. Despite dramatic advances in treatment and life expectancy, cystic fibrosis substantially reduces lifespan and its management is challenging. As people are living longer with this disease, cystic fibrosis-related diabetes has emerged as a common problem. While treatments have improved for many of these diseases, we have much to learn about the complex interaction between genetic and environmental factors that underlies their progression and which may provide avenues to prevention and new therapies.
Examples of NIDDK-supported research efforts in these areas include:
Studies of environmental factors that may alter thyroid function.
    Research building on discoveries about the specific effects of various cystic fibrosis-causing genetic mutations in order to develop therapies that counteract the disease at a molecular level.
    Studies increasing our understanding of how cells sense and respond to available fuel and nutrient levels.
    Experiments aiming to understand the molecular mechanisms underlying autoimmune disorders such Hashimoto’s thyroiditis and Graves disease.
    Research to understand the role of parathyroid hormone in bone health and to identify the best treatment for hyperparathyroidism, a condition in which the parathyroid glands produce too much hormone.
    Studies of bone health and fracture risk in relationship to diseases and conditions such as obesity and weight loss surgery; underweight; and type 1 and type 2 diabetes.In addition, NIDDK responds to questions and provides health information about endocrine diseases to people with endocrine diseases and to their families, health professionals, and the public via the NIDDK Health Information Center.

Research Updates and News
    Novel computational pipeline approach leads to discovery of possible new treatments for the endocrine disorder hyperparathyroidism
                Selective Fat Cell Elimination in Mice Leads to a Profound Increase in Bone Mass
                Succinate Regulates Muscle Adaptations to Exercise in Mice and Humans
                Fat cell signaling molecules identified as critical for regulating metabolic health in mice
                How the gut microbiome controls daily metabolic rhythmsView More News Articles
What We Do
To achieve its mission, NIDDK supports, conducts, coordinates, and plans research. NIDDK also provides data and samples from NIDDK-funded studies and explains research findings to health professionals and the public.Support Research
            NIDDK invests in basic, clinical and translational research and training at colleges, universities and other institutions.
Bioengineering, Biotechnology, and Imaging as applied to Diabetes, Metabolic, and Endocrine Diseases
    Cystic Fibrosis
    Diabetes and Metabolism HIV/AIDS
    Diabetes, Endocrine, and Metabolic Disease Translational Research
    Endocrine Pancreas
    Endocrine Tumors of the PancreasView all Research Programs & Contacts
        Conduct Research
            NIDDK investigators conduct biomedical research and training in the Institute's laboratories and clinical facilities in Maryland and Arizona.
Diabetes, Endocrinology, and Obesity Branch
    Laboratory of Bioorganic Chemistry
    Laboratory of Cell and Molecular Biology
    Laboratory of Cellular and Developmental Biology
    Laboratory of Endocrinology and Receptor BiologyView all Labs & Branches

Coordinate & Plan Research
            NIDDK takes multiple approaches to research planning and priority setting.
                
**Meetings & Workshops**
    There are no upcoming related meetings or workshops at this time.
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                **Strategic Plans & Reports**
    Diabetes in America
            NIDDK Strategic Plan for Research
            Diabetes in America, 3rd Edition
            Special Statutory Funding Program for Type 1 Diabetes Research: Progress Report
            Advances & Emerging Opportunities in Diabetes Research: A Strategic Planning Report of the Diabetes Mellitus Interagency Coordinating CommitteeView all Strategic Plans & Reports

Provide Access to Research Resources
            NIDDK makes publicly supported resources, data sets, and studies available to researchers.
                View all Research Resources

Provide Health Information
            NIDDK provides patient education information, practice tools for diagnosis and treatment, and statistics.
**General Public**
Endocrine and Metabolic Diseases Statistics
    Health Information about Endocrine Diseases
**Health Professionals**
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