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                    Pancreas Basic Research & Development

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        Disease Biology
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                Clinical DevelopmentPancreas Basic Research & Development
    Research on the development, structure, function, and diseases of the exocrine pancreas.
    The Pancreas Basic Research and Development program supports research on the structure, function, and diseases—excluding cancer and cystic fibrosis—of the exocrine pancreas.  Specific projects examine the hormonal and neural regulation of electrolyte, fluid, and enzyme secretion; receptors for secretagogues; and stimulus-secretion coupling mechanisms.  Also of interest are studies of gut-islet-acinar interrelations; organization and expression of pancreatic genes; and protein synthesis and export.

The program encourages work that advances our understanding of tissue injury, repair, and regeneration; the physiology and pathology of trophic responses; neural innervation; and transcapillary solute and fluid exchange. Information about pancreatic development has led to insights regarding nuclear transcription factors and signaling pathways regulating pancreatic progenitor/precursor cell expansion and differentiation.  The identification and characterization of progenitor cells that can support expansion of ductal/exocrine cell populations destroyed during acute or chronic pancreatitis, or pancreatic cancer, and factors that control differentiation of the descendants of these progenitors--along with a more complete understanding of the normal pancreas at each stage of development--is essential for future advances in detecting, preventing, and treating these diseases.
    NIDDK Program Staff
        Jose Serrano, M.D., Ph.D.
                    Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis; Drug Induced Liver Injury; Clinical Research on GI Diseases
Recent Funding Opportunities
                    View More Recent Funding Opportunities
        Posted:
                                4/10/2024
                            PA-24-184
                    Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Required)
                    
                    Summary
                Posted:
                                4/9/2024
                            PA-24-185
                    Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Not Allowed)
                    
                    Summary
                Posted:
                                4/2/2024
                            PAR-24-206
                    Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)
                    
                    Summary
                Posted:
                                3/27/2024
                            NOT-OD-24-078
                    Notice of Special Interest (NOSI): Supporting the Exploration of Cloud in NIH-supported Research
                    
                    Summary
                Posted:
                                3/26/2024
                            RFA-NS-25-012
                    HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
                    
                    SummaryView More Recent Funding Opportunities
Related Links
NIDDK Active Trials in Pancreatic Disease
    View related clinical trials from ClinicalTrials.gov.
    NIH Study Sections
    Study sections conduct initial peer review of applications in a designated scientific area.
    Visit the NIH’s Center for Scientific Review website to search for study sections.Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
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ResearchTraining
NIDDK supports the training and career development of medical and graduate students, postdoctoral
fellows, and physician scientists through institutional and individual grants.
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Diversity
Diversity Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
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Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
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NIDDK provides funding opportunities and resources to encourage translation of basic discoveries
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        Last Reviewed October 2023 Contact Us
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