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<article class="node node--type-science node--science-theme--blue node--view-mode-full">

  
    

  
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      <div class="responsive-container responsive-container-constrained breadcrumbs-container"><div class="breadcrumbs"><ul> <li class='breadcrumb-home'><a href='/'>Home</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-parent'><a href='/node/80002'><span class='back-to'> < Back To </span>The Science</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-current'>Cardiovascular Regenerative Medicine</li></ul></div></div>
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      <h1>Cardiovascular Regenerative Medicine</h1>
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            <div class="field field--name-field-component-lab-banner-descr field--type-text-long field--label-hidden field__item"><p>The Laboratory of Cardiovascular Regenerative Medicine, led by Dr. Manfred Boehm, is focused on identifying and better understanding the molecular mechanisms underlying human vascular diseases with the goal of developing new therapeutic approaches.</p>
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<span>Manfred Boehm, M.D.</span>

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              <div class="field__item"><p><strong><span><em>The Laboratory of Cardiovascular Regenerative Medicine has established the Patient-Centered Vascular Translational Program to conduct research on clinically relevant questions focused on vascular injury, remodeling and repair, and to translate research findings into the development of new therapeutic strategies</em></span></strong>.</p>

<p><span>The aims of the Vascular Translational Program align with the principles of precision medicine, investigating how individual variations in genes, environment, and lifestyle contribute to vascular disease. This program was designed to link high-throughput sequencing data with molecular disease mechanisms to facilitate the development of targeted therapies and through this program, we have already successfully identified the genetic cause and/or underlying mechanism of a variety of rare diseases. We are particularly interested in investigating the mechanisms of vascular remodeling triggered by injury or other perturbations such as dysregulated homeostasis, inflammation, calcification or endothelial dysfunction. We believe that improving our understanding of these processes will help us find solutions for disease mitigation and restoring the balance of the relevant biological processes.</span></p>

<p><strong><a href="https://www.nhlbi.nih.gov/science/cardiovascular-regenerative-medicine/research" rel="noreferrer">Learn More</a></strong><br />
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<span>Vascular Disease Discovery Protocol</span>

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												Do you have a heart or blood vessel disease, such as peripheral artery disease? This study aims to collect data and samples from people who have a heart or blood vessel disease. This may include blood tests, ultrasound exams, and heart and lung tests. Family members and healthy people may also participate. The results may help researchers better understand PAD and other heart and blood vessel diseases. Participants must be at least 2 years old. Women who are pregnant may not take part in some study activities. This study is located in Bethesda, Maryland.
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<span>Human Biospecimen Procurement and Analysis to Support Translational Research to Identify Genetic Etiology and Disease Mechanism(s) in Rare Genetic Vascular/Cardiovascular Diseases</span>

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												Would you like to help researchers understand how rare genetic problems may lead to cardiovascular and vascular diseases? This study will collect blood, saliva, and tissue samples to study the underlying causes of diseases. This study is located at the NIH Clinical Center in Bethesda, Maryland.
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												Do you have cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL) or want to help someone with the condition? This study aims to learn more about a rare genetic disease called CADASIL. This condition causes small blood vessels in the body to become narrow, which can block blood flow to the brain and lead to a stroke. The study includes blood, urine, and imaging tests. This study is located at the NIH Clinical Center in Bethesda, Maryland. 
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               <span>Authors: </span>St Hilaire C, Ziegler SG, Markello TC, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum RL, Kleta R, Gahl WA, Boehm M
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                2011 Feb 03</span>;364(5):432-42
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               <span>Authors: </span>Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, Stone DL, Chae JJ, Rosenzweig SD, Bishop K, Barron KS, Kuehn HS, Hoffmann P, Negro A, Tsai WL, Cowen EW, Pei W, Milner JD, Silvin C, Heller T, Chin DT, Patronas NJ, Barber JS, Lee CC, Wood GM,
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            N Engl J Med
      
                2014 Feb 06</span>;370(10):911-20
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                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/24552284" aria-label="Early-onset stroke and vasculopathy associated with mutations in ADA2." class="read-publications">Read Publication</a>
                            
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      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Montealegre Sanchez GA, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CC, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim 
            </div>
                                                                                                                        
            <span>
            N Engl J Med
      
                2014 Jul 07</span>;371(6):507-18
        </div>
        <div class="flex-item">
                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/25029335" aria-label="Activated STING in a vascular and pulmonary syndrome." class="read-publications">Read Publication</a>
                            
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</article>
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                      <div class="field__item">

<article class="node node--type-publication node--view-mode-short-teaser">
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">TGF- β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling.</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Cooley BC, Nevado J, Mellad J, Yang D, St Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M
            </div>
                                                                                                                        
            <span>
            Sci Transl Med
      
                2014 Feb 12</span>;6(227):227ra34
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        <div class="flex-item">
                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/24622514" aria-label="TGF- β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling." class="read-publications">Read Publication</a>
                            
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<article class="node node--type-publication node--view-mode-short-teaser">
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Impaired angiogenesis and extracellular matrix metabolism in autosomal-dominant hyper-IgE syndrome.</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Dmitrieva NI, Walts AD, Nguyen DP, Grubb A, Zhang X, Wang X, Ping X, Jin H, Yu Z, Yu ZX, Yang D, Schwartzbeck R, Dalgard CL, Kozel BA, Levin MD, Knutsen RH, Liu D, Milner JD, López DB, O'Connell MP, Lee CR, Myles IA, Hsu AP, Freeman AF, Holland SM, Chen G
            </div>
                                                                                                                        
            <span>
            J Clin Invest.
      
                2020 Aug 03</span>;130(8):4167-4181
        </div>
        <div class="flex-item">
                                                    <a href="https://pubmed.ncbi.nlm.nih.gov/32369445/" aria-label="Impaired angiogenesis and extracellular matrix metabolism in autosomal-dominant hyper-IgE syndrome." class="read-publications">Read Publication</a>
                            
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  <div class="layout layout--twocol-section layout--twocol-section--67-33">

          <div  class="layout__region layout__region--first">
        <div class="block block-layout-builder block-field-blocknodesciencefield-senior-investigator">
  
    
      

                        <div class="field field--name-field-senior-investigator field--type-entity-reference field--label-hidden field__item">

<div class="component-senior-investigator responsive-container responsive-container-constrained">
    <h2>Meet the Team</h2>

    <div class="meet-the-team">
        <div class="block-senior-investigator-bg senior-bg-light-blue">
            <div class="senior-image">
                                    
            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="250" height="250" alt="manfred" data-src="/sites/default/files/styles/square_image_250x250/public/2021-06/0011208021_0.jpeg?itok=F4FX_Ylo" class="b-lazy image-style-square-image-250x250" />


</div>
      
                            </div>

            <div class="senior-info">
                <h3 class="senior-name">
                    Manfred Boehm, M.D.
                </h3>
                <div class="senior-title">
                    
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Senior Investigator</div>
      
                </div>
                <div class="senior-bio">
                    
            <div class="clearfix text-formatted field field--name-field-person-bio field--type-text-with-summary field--label-hidden field__item"><p><span><span><span>Manfred Boehm received his M.D. in 1993 from the University of Heidelberg, Germany and did his residency in internal medicine at the Franz-Volhard-Clinic, Berlin. Before arriving at the NIH and NHLBI, he was a research fellow at the Max Delbrück Center for Molecular Medicine, Berlin from 1996 to 1997, and the University of Michigan, Ann Arbor from 1997 to 1999. He joined NHLBI as a research fellow in 1999 and has been an Investigator since 2003. Dr. Boehm received a Foundation for Advanced Education in the Sciences Award for Research Excellence from the NIH. He was also the recipient the NHLBI Science Awards in 2015 for his team’s research on rare inherited vascular diseases in children. Since 2018, Dr. Boehm has been the Branch Chief of the NHLBI Translational Vascular Medicine Branch, which focuses on studying <span><span>vascular disease mechanisms to develop novel treatment strategies to better serve our patients with vascular diseases through genomic and molecular high throughput approaches to help understand diseases processes in common and rare inherited disease populations.</span></span> </span></span></span></p>

<ul><li><a class="ytp-title-link yt-uix-sessionlink" href="https://www.youtube.com/watch?v=NMEYSMscPl0" rel="noreferrer">NHLBI Orloff Award 2015: Manfred Boehm</a></li>
</ul></div>
      
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            <div class="field field--name-field-component-contact-lab field--type-entity-reference-revisions field--label-hidden field__item">

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    <h3>Contact the lab</h3>
    <div class="component-contact-lab-content">
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            <a href="http://maps.google.com/?q=10 Center Dr
Bethesda, MD 20814
United States">
                
            <div class="field field--name-field-lab-location field--type-address field--label-hidden field__item"><p class="address" translate="no"><span class="address-line1">10 Center Dr</span><br>
<span class="locality">Bethesda</span>, <span class="administrative-area">MD</span> <span class="postal-code">20814</span><br>
<span class="country">United States</span></p></div>
      
            </a>
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            <i class="fas fa-phone-alt"></i>
            <div class="phone-fax-column">
                <div class="component-contact-lab-phone">
                    <span>Phone: </span>
                    <a href="tel:+1301-435-7211">
                        
            <div class="field field--name-field-phone-number field--type-string field--label-hidden field__item">301-435-7211</div>
      
                    </a>
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                <div class="component-contact-lab-fax"><span>Fax: </span>
            <div class="field field--name-field-fax-number field--type-string field--label-hidden field__item">301-451-7090</div>
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      <div class="block block-layout-builder block-field-blocknodesciencefield-component-lab-members">
  
    
      



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<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Marta" data-src="/sites/default/files/styles/square_image/public/2020-12/avatar_4.png?itok=F3XOL2lD" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Marta Cardenas </span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Patient Care Coordinator</div>
      
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<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

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<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Katherine" data-src="/sites/default/files/styles/square_image/public/2020-12/avatar_2.png?itok=j6bYyOkX" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Katherine Carney, RN, BSC, CCRC</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Research Nurse Specialist</div>
      
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<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

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<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="avatar" data-src="/sites/default/files/styles/square_image/public/2021-01/avatar.png?itok=5w78vgCy" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Guibin Chen, M.D., Ph.D.</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Staff Scientist</div>
      
    </div>

        <div class="node__content contact-info">
                <div class="contact-info-email">
            <i class="fas fa-envelope"></i>
             <a href="mailto:chengb@mail.nih.gov" >
                 chengb@mail.nih.gov
            </a>
        </div>
        
            </div>
    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

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<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="avatar" data-src="/sites/default/files/styles/square_image/public/2020-12/avatar.png?itok=1Q2KCglx" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Cornelia Cudrici, M.D.</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Assistant Research Physican</div>
      
    </div>

    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

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            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Zambia" data-src="/sites/default/files/styles/square_image/public/2020-12/avatar_8.png?itok=O9jKEsr5" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Zambia Davis </span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Administrative Assistant</div>
      
    </div>

    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

    <div class="profile-image">
                    
            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Elisa" data-src="/sites/default/files/styles/square_image/public/2020-12/avatar_0.png?itok=n0rl0Vr_" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Elisa Ferrante, Ph.D.</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Staff Scientist</div>
      
    </div>

    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

    <div class="profile-image">
                    
            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Jacob" data-src="/sites/default/files/styles/square_image/public/2020-12/avatar_1.png?itok=9enjPO8M" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Jacob Furcolo </span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Postbaccalaureate IRTA Fellow</div>
      
    </div>

    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

    <div class="profile-image">
                    
            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Rebecca" data-src="/sites/default/files/styles/square_image/public/2020-12/RebeccaHarper.jpg?itok=vDNI62YF" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Rebecca Harper, Ph.D.</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Postdoctoral Visiting Fellow</div>
      
    </div>

    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

    <div class="profile-image">
                    
            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Rebecca" data-src="/sites/default/files/styles/square_image/public/2020-12/avatar_6.png?itok=iaCLUfKR" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Rebecca  Huffstutler, CRNP</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Family Nurse Practioner</div>
      
    </div>

    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

    <div class="profile-image">
                    
            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Delong" data-src="/sites/default/files/styles/square_image/public/2020-12/delong-liu02.jpg?itok=6yIXj_Uh" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Delong Liu, M.D.</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Staff Scientist</div>
      
    </div>

    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

    <div class="profile-image">
                    
            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Atul" data-src="/sites/default/files/styles/square_image/public/2020-12/AtulMehta.jpg?itok=PNGo-0rT" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Atul Mehta, M.D.</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Critical Care Fellow</div>
      
    </div>

    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

    <div class="profile-image">
                    
            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Keron" data-src="/sites/default/files/styles/square_image/public/2020-12/avatar_3.png?itok=4-91VwrN" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Keron Navarengom, M.D.</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Special Volunteer</div>
      
    </div>

    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

    <div class="profile-image">
                    
            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Doug" data-src="/sites/default/files/styles/square_image/public/2020-12/DougRosing.JPG?itok=6VQkX_BJ" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Douglas Rosing, M.D.</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Senior Research Physician</div>
      
    </div>

    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

    <div class="profile-image">
                    
            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Schwartzbeck" data-src="/sites/default/files/styles/square_image/public/2017-12/robin-schwartzbeck.jpg?itok=7P5kVDuw" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Robin  Schwartzbeck </span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Senior Research Assistant</div>
      
    </div>

        <div class="node__content contact-info">
                <div class="contact-info-email">
            <i class="fas fa-envelope"></i>
             <a href="mailto:rs420e@nih.gov" >
                 rs420e@nih.gov
            </a>
        </div>
        
            </div>
    </article>
</div>
            <div class="field__item">
<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

    <div class="profile-image">
                    
            <div class="field field--name-field-person-image field--type-image field--label-hidden field__item">  
<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Yang" data-src="/sites/default/files/styles/square_image/public/2017-12/Dan%20Yang%20thumb.jpg?itok=C5rM5DQS" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Dan Yang, M.D., Ph.D.</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Staff Scientist</div>
      
    </div>

        <div class="node__content contact-info">
                <div class="contact-info-email">
            <i class="fas fa-envelope"></i>
             <a href="mailto:yangd4@mail.nih.gov" >
                 yangd4@mail.nih.gov
            </a>
        </div>
        
            </div>
    </article>
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<article class="node node--type-nhlbi-person node--view-mode-lab-member-component">

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<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Quan" data-src="/sites/default/files/styles/square_image/public/2020-12/avatar_7.png?itok=V6OEn7PP" class="b-lazy image-style-square-image" />


</div>
      
            </div>
    
            <h4>
            
<span>Quan Yu, M.S.</span>

        </h4>
        

    <div class="node__content">
        
            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Biologist</div>
      
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<h2 class="field--name-field-component-section-titl component-section-section-title">Videos</h2>

            <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden clearfix field__item"><h3>NHLBI Orloff Award 2015: Manfred Boehm</h3>

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