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                    Acute & Chronic Pancreatitis

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        Research Programs & Contacts
        Acute & Chronic Pancreatitis
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        Disease Biology
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                Pre-Clinical Development
                Clinical DevelopmentAcute & Chronic Pancreatitis
    Research on the etiology and pathogenesis of acute and chronic pancreatitis.
    Pancreatitis is a syndrome that is characterized by pain associated with inflammation and damage to the pancreas. Relapsing or chronic pancreatitis can lead to exocrine and endocrine pancreatic insufficiency. Major causes of pancreatitis are alcohol use, cholelithiasis, drug toxicity, and infections. In some cases there may be a genetic basis; however, a significant percentage of cases are idiopathic.
The Acute and Chronic Pancreatitis program supports a broad range of research topics on the etiology and pathogenesis of acute and chronic pancreatitis. Some examples are: the elucidation of mechanisms by which alcohol and drugs induce or promote premature activation of pancreatic enzymes (zymogens) within the pancreas directly or indirectly; the determination of the role of diet, including fat and protein, in the modulation of gene expression and synthesis of various secretagogues; the roles of cytokines, chemokines, adhesion molecules, and inflammatory leukocytes in the initiation and progression of inflammation of the pancreas; the characterization of the molecular mechanisms of pancreatic stellate cell activation leading to increased deposition of extracellular matrix proteins and fibrosis; the characterization of the relationship between pancreatitis, diabetes, obesity, and pancreatic cancer; and the identification and characterization of biomarkers of early cell or tissue perturbation that can be used for diagnosis of the disease.
    NIDDK Program Staff
        Dana K. Andersen, M.D.
                    Observational and Investigational Clinical Research; Biomedical Devices, Surgical Interventions, and Medications
                Jose Serrano, M.D., Ph.D.
                    Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis; Drug Induced Liver Injury; Clinical Research on GI Diseases
Recent Funding Opportunities
                    View More Recent Funding Opportunities
        Posted:
                                4/10/2024
                            PA-24-184
                    Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Required)
                    
                    Summary
                Posted:
                                4/9/2024
                            PA-24-185
                    Mentored Patient-Oriented Research Career Development Award (Parent K23  Independent Clinical Trial Not Allowed)
                    
                    Summary
                Posted:
                                4/2/2024
                            PAR-24-206
                    Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)
                    
                    Summary
                Posted:
                                3/27/2024
                            NOT-OD-24-078
                    Notice of Special Interest (NOSI): Supporting the Exploration of Cloud in NIH-supported Research
                    
                    Summary
                Posted:
                                3/26/2024
                            RFA-NS-25-012
                    HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
                    
                    SummaryView More Recent Funding Opportunities
Related Links
NIDDK Active Trials in Pancreatic Disease
    View related clinical trials from ClinicalTrials.gov.
    NIH Study Sections
    Study sections conduct initial peer review of applications in a designated scientific area.
    Visit the NIH’s Center for Scientific Review website to search for study sections.Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
    NIDDK Central Repository for access to clinical resources including data and biospecimens from NIDDK-funded studies.
    NIDDK Information Network (dkNET) for simultaneous search of digital resources, including multiple datasets and biomedical resources relevant to the mission of the NIDDK.Additional Research Programs
ResearchTraining
NIDDK supports the training and career development of medical and graduate students, postdoctoral
fellows, and physician scientists through institutional and individual grants.
Learn about NIDDK Research Training Programs
Diversity
Diversity Programs
The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity Programs
Small Business
Small Business Programs
NIDDK participates in the Small Business Innovation Research (SBIR) and Small Business Technology
Transfer (STTR) programs.
These programs support innovative research conducted by small businesses that has the potential for
commercialization.
Learn about NIDDK Small Business Programs
Human SubjectsResearch
Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
Learn about Human Subjects Research
TranslationalResearch
NIDDK provides funding opportunities and resources to encourage translation of basic discoveries
into novel therapeutics.
Learn about NIDDK Translational Research Opportunities

Meetings & Workshops
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    Learn about current projects and view funding opportunities sponsored by the NIH Common Fund.
    Planning to Apply? Register Early
    Registration is required at eRA Commons and grants.gov and can take 4 weeks.
        Last Reviewed October 2023 Contact Us
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