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          About NIAMS
          Sarthak Gupta, M.D.





Sarthak Gupta, M.D.


Associate Research Physician
    Lupus Clinical Trials Unit
    Clinical Research @ NIAMS Image
              Headshot of a man wearing a labcoat. 
            Contact Information

                                                  301-443-8541
                
                                                9000 Rockville Pike
                  
                  
            Building 10, CRC 5-5521
      
                                   Bethseda MD 20892
                
                                                sarthak.gupta@nih.gov 
                                          Media Resources
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                LCTU-headshot-gupta-2.jpg 
                Summary
          Dr. Sarthak Gupta is a board-certified adult rheumatologist. He received his medical degree from Jawaharlal Nehru Medical College, Aligarh, India, and completed a residency in Internal Medicine at the State University of New York at Buffalo. He then moved to NIAMS to pursue a three-year adult rheumatology fellowship in 2011 and also served as the chief fellow for the training program. During his fellowship, he worked on defining the spectrum of anticytokine autoantibodies in autoimmune diseases. On completion of his fellowship, Dr. Gupta was promoted to Henry Metzger Scholar and subsequently joined the Systemic Autoimmunity Branch at NIAMS, where he worked on understanding the sex differences in neutrophil biology in systemic autoimmune diseases. He has also been an investigator on several ongoing clinical trials using novel therapies in systemic autoimmune diseases. In 2018 he accepted the position of assistant research physician at NIAMS where he continues to pursue his interest in translational research and developing innovative interventional studies in autoimmune diseases.

Dr. Gupta is an active clinician and a core faculty for the rheumatology training program at NIAMS. He has also received numerous awards and grants for his research, including the Rheumatology Research Foundation's Scientist Development Award, the 34th European Workshop for Rheumatology Research Travel Award and the 2017 ACR/EULAR Exchange Program award. 

            Scientific Publications
              Quantification of Neutrophils Undergoing NET Formation and Distinguishing Mechanisms of Neutrophil Cell Death by Use of a High-Throughput Method.

    Nakabo S, Kaplan MJ, Gupta S
        

                    Methods Mol Biol.
        
                    2022;
        
                    2543().
        
                    doi: 10.1007/978-1-0716-2553-8_11
                            PMID: 36087264
  Joint-Predominant Rheumatic Complications of Immune Checkpoint Inhibitor Therapy in Patients with Thymic Epithelial Tumors.

    Mullenix C, Ballman M, Chen H, Swift S, McAdams MJ, Tsai YT, Donahue RN, Poretta T, Gupta S, Loehrer PJ, Schlom J, Gulley JL, Rajan A
        

                    Oncologist.
        
                    2022 Apr 5;
        
                    27(4).
        
                    doi: 10.1093/oncolo/oyac026
                            PMID: 35380721
  Lupus-like autoimmunity and increased interferon response in patients with STAT3-deficient hyper-IgE syndrome.

    Goel RR, Nakabo S, Dizon BLP, Urban A, Waldman M, Howard L, Darnell D, Buhaya M, Carmona-Rivera C, Hasni S, Kaplan MJ, Freeman AF, Gupta S
        

                    J Allergy Clin Immunol.
        
                    2021 Feb;
        
                    147(2).
        
                    doi: 10.1016/j.jaci.2020.07.024
                            PMID: 32768442
  Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism.

    Gupta S, Nakabo S, Blanco LP, O'Neil LJ, Wigerblad G, Goel RR, Mistry P, Jiang K, Carmona-Rivera C, Chan DW, Wang X, Pedersen HL, Gadkari M, Howe KN, Naz F, Dell'Orso S, Hasni SA, Dempsey C, Buscetta A, Frischmeyer-Guerrerio PA, Kruszka P, Muenke M, Franco LM, Sun HW, Kaplan MJ
        

                    Proc Natl Acad Sci U S A.
        
                    2020 Jul 14;
        
                    117(28).
        
                    doi: 10.1073/pnas.2003603117
                            PMID: 32601182
  Bite of the wolf: innate immune responses propagate autoimmunity in lupus.

    Gupta S, Kaplan MJ
        

                    J Clin Invest.
        
                    2021 Feb 1;
        
                    131(3).
        
                    pii: 144918. doi: 10.1172/JCI144918
                            PMID: 33529160
  A High-Throughput Real-Time Imaging Technique To Quantify NETosis and Distinguish Mechanisms of Cell Death in Human Neutrophils.

    Gupta S, Chan DW, Zaal KJ, Kaplan MJ
        

                    J Immunol.
        
                    2018 Jan 15;
        
                    200(2).
        
                    doi: 10.4049/jimmunol.1700905
                            PMID: 29196457
  Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine'.

    Gupta S, Nakabo S, Chu J, Hasni S, Kaplan MJ
        

                    Ann Rheum Dis.
        
                    2023 Oct;
        
                    82(10).
        
                    doi: 10.1136/annrheumdis-2020-219648
                            PMID: 33452005
  Distinct Functions of Autoantibodies Against Interferon in Systemic Lupus Erythematosus: A Comprehensive Analysis of Anticytokine Autoantibodies in Common Rheumatic Diseases.

    Gupta S, Tatouli IP, Rosen LB, Hasni S, Alevizos I, Manna ZG, Rivera J, Jiang C, Siegel RM, Holland SM, Moutsopoulos HM, Browne SK
        

                    Arthritis Rheumatol.
        
                    2016 Jul;
        
                    68(7).
        
                    doi: 10.1002/art.39607
                            PMID: 26815287
  Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus.

    Hasni SA, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Carlucci PM, Wang X, Naqi M, Playford MP, Goel RR, Li X, Biehl AJ, Ochoa-Navas I, Manna Z, Shi Y, Thomas D, Chen J, Biancotto A, Apps R, Cheung F, Kotliarov Y, Babyak AL, Zhou H, Shi R, Stagliano K, Tsai WL, Vian L, Gazaniga N, Giudice V, Lu S, Brooks SR, MacKay M, Gregersen P, Mehta NN, Remaley AT, Diamond B, O'Shea JJ, Gadina M, Kaplan MJ
        

                    Nat Commun.
        
                    2021 Jun 7;
        
                    12(1).
        
                    doi: 10.1038/s41467-021-23361-z
                            PMID: 34099646
  Safety and Tolerability of Omalizumab: A Randomized Clinical Trial of Humanized Anti-IgE Monoclonal Antibody in Systemic Lupus Erythematosus.

    Hasni S, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Joyal E, Fike A, Manna Z, Auh S, Shi Y, Chan D, Carlucci P, Biehl A, Dema B, Charles N, Balow JE, Waldman M, Siegel RM, Kaplan MJ, Rivera J
        

                    Arthritis Rheumatol.
        
                    2019 Jul;
        
                    71(7).
        
                    doi: 10.1002/art.40828
                            PMID: 30597768
  Pulmonary Manifestations of Primary Sjögren's Syndrome: Underlying Immunological Mechanisms, Clinical Presentation, and Management.

    Gupta S, Ferrada MA, Hasni SA
        

                    Front Immunol.
        
                    2019;
        
                    10().
        
                    doi: 10.3389/fimmu.2019.01327
                            PMID: 31249572
  Use of Magnetic Resonance Imaging to Identify Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis.

    Subedi A, Williams SG, Yao L, Maharjan S, Strauss J, Sharon E, Thomas A, Apolo AB, Gourh P, Hasni SA, Gulley JL, Kaplan MJ, Katz JD, Gupta S
        

                    JAMA Netw Open.
        
                    2020 Feb 5;
        
                    3(2).
        
                    doi: 10.1001/jamanetworkopen.2020.0032
                            PMID: 32101306
  Erosive Deforming Inflammatory Arthritis in a Patient With Cervical Adenocarcinoma.

    Subedi A, Strauss J, Gupta S
        

                    JAMA Oncol.
        
                    2019 Nov 1;
        
                    5(11).
        
                    doi: 10.1001/jamaoncol.2019.3140
                            PMID: 31556909
  Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

    Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, Pei W, Balanda N, Ross DL, Ospina Cardona D, Wu Z, Patel B, Manthiram K, Groarke EM, Gutierrez-Rodrigues F, Hoffmann P, Rosenzweig S, Nakabo S, Dillon LW, Hourigan CS, Tsai WL, Gupta S, Carmona-Rivera C, Asmar AJ, Xu L, Oda H, Goodspeed W, Barron KS, Nehrebecky M, Jones A, Laird RS, Deuitch N, Rowczenio D, Rominger E, Wells KV, Lee CR, Wang W, Trick M, Mullikin J, Wigerblad G, Brooks S, Dell'Orso S, Deng Z, Chae JJ, Dulau-Florea A, Malicdan MCV, Novacic D, Colbert RA, Kaplan MJ, Gadina M, Savic S, Lachmann HJ, Abu-Asab M, Solomon BD, Retterer K, Gahl WA, Burgess SM, Aksentijevich I, Young NS, Calvo KR, Werner A, Kastner DL, Grayson PC
        

                    N Engl J Med.
        
                    2020 Dec 31;
        
                    383(27).
        
                    doi: 10.1056/NEJMoa2026834
                            PMID: 33108101 
          Education
              
            **Jawaharlal Nehru Medical College, Aligarh, India**M.D.             
                        Experience
              
            **Henry Metzger Scholar in Translational Medicine**National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD**Clinical Fellow, Adult Rheumatology**National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD**Resident, Internal Medicine**State University of New York at Buffalo, Buffalo, NY


Last Updated: March 2024


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