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		Search Text: Home/About the NHLBI/Strategic Vision/< Back ToStrategic Goals and Objectives/Optimize clinical and implementation research to improve health and reduce disease

Objective 6:  
Optimize clinical and implementation research to improve health and reduce disease
                New methodologies, research frameworks, and resources need to be developed to refine the conduct of clinical studies and implementation research, while also improving the overall efficiency and effectiveness of the research enterprise. Current challenges include difficulties in recruitment of research participants and effective translation of knowledge gained from these studies into programs and policies that improve health at the clinic and community levels.
                        Envision a future in which we are able to...
      
                            
    Use novel platforms that link electronic health records and personal health data to facilitate the identification and enrollment of participants in clinical research and empower research volunteers to self-identify.
              Accelerate the translation of discovery into practice by embedding HLBS research platforms (e.g., clinical epidemiology registries, clinical trial networks, and implementation science programs) within “learning” health care systems, thereby engaging the clinical care and patient communities; leveraging electronic health records, patient registries, and existing datasets; and creating an integrative interface between clinical research and practice.
    
                        Related Priorities
                        Compelling Question
                                                                                                    What methods and technologies are effective for increasing awareness of and participation in clinical research, as well as awareness of and access to evidence-based diagnostics and therapeutics, including emerging approaches to care? (6.CQ.01)
    Compelling Question
                                                                                                    What clinical trial designs are best for studying the chronobiology of drug delivery? (6.CQ.02)
    Compelling Question
                                                                                                    How can we engage relevant stakeholders, including patients, private entities, and federal agencies, to improve the clinical research enterprise and address critical needs such as standardized informed consent and cost containment? (6.CQ.03)
    Critical Challenge
                                                                                                    Synergy and collaboration among people at the MD and PhD level for; basic science; translational, patient-oriented researchers; community and population scientists; and individuals from multiple disciplines (e.g., engineers, clinicians, subspecialists, generalists, bioinformatics experts, academics, nonprofit organizations, industry) are needed to enhance and expedite advances in HLBS research. (6.CC.01)
    Critical Challenge
                                                                                                    Improvements in clinical trial design, population estimations, project management, and other practices are needed to achieve timely trial completion. (6.CC.02)
  
      
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                        Overarching ObjectivesUnderstand normal biological function and resilienceInvestigate newly discovered pathobiological mechanisms important to the onset and progression of HLBS diseasesInvestigate factors that account for differences in health among populationsIdentify factors that account for individual differences in pathobiology and in responses to treatmentsDevelop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseasesOptimize clinical and implementation research to improve health and reduce diseaseLeverage emerging opportunities in data science to open new frontiers in HLBS researchFurther develop, diversify, and sustain a scientific workforce capable of accomplishing the NHLBI’s mission Back To Top Link
  

        

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