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                    Digestive Diseases Research Core Centers

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        Digestive Diseases Research Core Centers
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                Clinical DevelopmentDigestive Diseases Research Core Centers
    Bringing together basic and clinical investigators to enhance the impact of their digestive and/or liver diseases research.
    NIDDK Program Staff
        Peter Perrin, Ph.D.
                    Basic and Translational Mucosal Immunology and Inflammation
    Funding for Digestive Diseases Research Core Centers (DDRCC)
NIDDK funds Digestive Diseases Centers via P30. Please see the DDRCC Application Resources for required tables and addition documentation.
View the DDRCC current schedule of review for funded centers.
Resources and Services Available from Digestive Diseases Research Core Centers
Digestive Diseases Research Core Centers generate investigative resources that can be made available to the broader research community. Centers also often support pilot and feasibility programs that fund small grants to generate preliminary data to include in larger grant applications and offer enrichment activities.
Information about Digestive Disease Research Center Sites
The NIDDK aims to integrate, coordinate, and foster interdisciplinary cooperation between groups of established investigators that conduct high-quality research on digestive and/or liver diseases.  An existing base of outstanding digestive and/or liver disease-related research is a prerequisite for the establishment of a Center.  Research in these Centers focuses on the etiology, treatment, and prevention of digestive and/or liver diseases.  Each Digestive Diseases Research Core Center has its own individual theme, which reflects the research projects and interests of the Investigators constituting its membership.  A Center’s theme serves to focus its activities to meet the needs of its members and facilitate a defined area of NIDDK-related digestive or liver diseases science. Further information about the Centers can be found on the individual centers’ websites.
**Center for Molecular Studies in Digestive and Liver Diseases (University of Pennsylvania)**
**Research Aims:** The scientific focus of the Center revolves host-environmental interactions in digestive and liver disease research from bench to bedside. Research amongst Center Investigators includes the molecular regulation of cellular processes in the digestive tract and liver, how they are integrated with the immune system, and their responses to environmental exposures such as diet and the microbiota. The Center is divided into three thematic areas: Intestinal Biology, Liver Biology, and Microbiology/Immunology. Center resources include four scientific cores to support research in both model systems and human subjects, a pilot project program, weekly seminar series, an annual retreat, and various enrichment programs.
    **Activities & Services**
    Cores
        Molecular Pathology & Imaging Core (MPIC)
            Host-Microbial Analytic and Repository Core (H-MARC)
            Genetically-modified Mouse Core (GMMC)
            Biomedical Data Sciences Core (BDSC)
        Pilot & Feasibility Program
        The goal of this program is to provide funds to support innovative exploratory studies in digestive and liver disease research that utilize Center biomedical research core facilities and will ultimately lead to extramural funding. The primary goal of this program is to support young investigators although established investigators in other areas of biomedical research who wish to apply their expertise to a problem in digestive and liver disease as well as those who wish to study an area that represents a significant departure from currently funded work are welcome to apply.**Center for the Study of Inflammatory Bowel Disease (Massachusetts General Hospital)**
**Research Aims:**CSIBD continues to promote and facilitate digestive disease research that yields insight into inflammatory bowel disease pathogenesis and leads to therapeutic advancements.
    **Activities & Services**
    Cores
        Human Genetics and Microbiome Core
            Cell Circuits and Immunology Core
            Cellular and In Vivo Models Core
            Clinical Core
        Pilot & Feasibility Program
        Young investigators (senior fellows or junior faculty) working in areas that will improve our understanding of basic processes relevant to inflammatory bowel disease
            Established investigators initiating a new area of research in their laboratories relevant to mechanisms underlying inflammatory bowel disease**Cincinnati Digestive Health Center (Cincinnati Children’s Hospital Medical Center)**
**Research Aims:**To promote research that will yield insights into the fundamental processes and pathogenic mechanisms of digestive disease in children and generate innovative treatment to restore digestive health.
    The Center’s long-term goals are to improve child health through better diagnosis, treatments and outcomes that will emerge from highly innovative work in our three key focus areas: 1) Mechanisms of Liver Disease, 2) Digestive Disease and Immunity, and 3) Stem Cell and Organoid Modeling of Digestive Diseases. Each focus area brings opportunities for a major impact on the digestive health of children, helps advance the national research agenda, and creates a unique environment to integrate research into patient care.
    **Activities & Services**
    Cores
        Gene Analysis Core
            Integrative Morphology Core
            Stem Cell/Organoid Core and Genome Editing Core
            Clinical Component
        Pilot & Feasibility Program
        Supports innovative pilot projects that will lead to extramurally funded research and expansion of digestive disease research. The three complementary aims:
            To foster the career development of junior digestive disease investigators
                To encourage established investigators in other areas of biomedical research to extend their expertise to digestive disease research
                To support highly focused new projects from established investigators exploring innovative new ideas that represent a significant departure from their funded research
            Applications will be considered in all areas of digestive disease research with particular emphasis on the following Digestive Health Center (DHC) focus areas:
            Mechanisms of Liver Disease
                Digestive Disease and Immunity
                Stem Cell and Organoid Modeling of Digestive Diseases**Cleveland Digestive Diseases Research Core Center (Case Western Reserve University)**
**Research Aims:**Cross-institutional and multi-disciplinary program between Case Western Reserve University (CWRU), University Hospitals Cleveland Medical Center (UHCMC), the Cleveland Clinic (CCF), and the Louis Stokes VA Medical Center (LSVAMC). The center’s two major themes are digestive inflammation and intestinal tumorigenesis, both of which represent well-established areas of collaborative investigation at CWRU.
    **Activities & Services**
    Cores
        Biorepository Core
            Histology/Imaging Core
            Mouse Models Core
            Clinical Component
        Pilot & Feasibility Program
        Promote the development of independent research programs of junior investigators with an interest in digestive disease research by providing pilot resources;
            Develop new research initiatives that will lead to competitive grant applications; and
            Attract talented, established investigators in other fields to apply their research skills and expertise to digestive disease-related investigations.**Columbia University Digestive and Liver Disease Research Center (Columbia University)**
**Research Aims:** The CU-DLDRC seeks to contribute to improved prevention, detection and therapy of digestive diseases through the application of creative concepts, cutting-edge research methods, innovation and multidisciplinary team science, with a strong emphasis on clinical relevance and translation. Its interdisciplinary group of basic, translational and clinical researchers strives to provide improved understanding of disease-driving pathways, cell-cell interactions and therapeutic targets in digestive and liver diseases. The Center encompasses two thematic areas, “Epithelial Homeostasis, Metabolism and Regeneration” and “Epithelial Interactions in Inflammation and Preneoplasia”. CU-DLDRC resources include four biomedical cores, a pilot and feasibility program, and an enrichment program.
    **Activities and Services**
    Cores
        Clinical Biospecimen and Research Core (CBRC)
            Bioinformatics and Single Cell Analysis Core (BSCAC)
            Organoid and Cell Culture Core (OCCC)
            Bioimaging Core (BIC)
        Pilot & Feasibility Program
        Early career basic or clinical investigators (without R01 or equivalent funding) or basic-clinical teams that seek to explore digestive- and liver-focused research topics
            Established basic or clinical investigators seeking a new area of research in their laboratories relevant to digestive and liver disease
        Enrichment Program
        The enrichment program seeks to foster education and a collaborative environment in the CU-DLDRC through regular seminars, symposia and an annual center retreat
            Promote the careers of trainees and new investigators through workshops and a dedicated mentorship program
            Uphold the values of diversity, equity and inclusion in all education and career-promoting activities of enrichment program as well as entire CU-DLDRC
            Increase scientific education and training through mini-sabbaticals and interactions with other DDRCCs and participation in local, regional and national conferences**Harvard Digestive Diseases Center (Harvard University)**
**Research Aims:** The **Harvard Digestive Disease Center (HDDC)** is a community of scientists focused on understanding the cellular, *immune, and microbial biology of mucosal surfaces lining the alimentary tract:* this is **the Center’s Theme.** We aim to elucidate the integrated cell and molecular biology of the epithelial, immune, neuronal, mesenchymal, and microbial cell types that comprise the complex ecosystem of the gut. **Our work has impact on**the inflammatory and non-inflammatory diseases of the stomach, intestine, and colon; on basic tissue and organ physiology; and on the gut microbiome and its interface with the host including effects on metabolism.
    The HDDC includes scientists in *4 major areas of research* that are basic to understanding the mechanisms of normal digestive tract function and the pathogenesis of disease:Cell, Developmental, and Stem Cell Biology of the Alimentary Tract
        Innate and Adaptive Mucosal Immunology and Microbial Pathogenesis
        Gut Microbiology and Metabolism
        Clinical and Translational Research on the Alimentary Tract
    Our signature research strategy fosters basic experimental biology, including discovery and computational approaches, and the Center supports a rapidly expanding program in human clinical and translational research.
    We have a major commitment to training, mentoring, and supporting young scientists in digestive disease research and to fostering the early careers of new faculty recruited to the HMS campus.**The overarching mission of the HDDC is to foster better clinical, translational, and basic science in fields related to the digestive diseases by:**
    **Connecting People,**
        **Creating Opportunity,**
        **Providing Critical Technologies, and**
        **Extending Resources.****Activities & Services**
    Cores
        CORE B: Microscopy and Histopathology Core
            CORE C: Epithelial Cell Biology and Mucosal Immunology Core
            CORE D: Gnotobiotic, Microbiology, and Metagenomics Core
            Clinical and Translational Research Program
            Program in Critical Resources
        Pilot & Feasibility Program
        The HDDC is focused on the study of epithelial cell function and mucosal biology in inflammation, host defense, and cancer of the gastrointestinal tract and related mucosal surfaces. Pilot & Feasibility projects will be considered for support if they relate directly or indirectly to this mission. The program primarily targets young investigators in the process of establishing their independent research careers, but also allows established investigators from other fields to initiate digestive disease-related research.**Mayo Clinic Center for Cell Signaling in Gastroenterology (Mayo Clinic)**
**Research Aims:**The mission of the Center is to provide a facilitative infrastructure that supports meaningful interactions among multidisciplinary scientists investigating cell signaling mechanisms in gastrointestinal cells and therapeutically exploiting these pathways to improve the health of patients with digestive diseases.
    **Activities & Services**
    Cores
        Clinical Core
            Epigenomics Core
            Optical Microscopy and Microfluidics Core
            Pilot & Feasibility Program
            Supports both new investigators just beginning their careers in digestive diseases research and innovative research proposals from experienced investigators who plan to change their area of research to digestive diseases.**MUSC Digestive Disease Research Core Center (Medical University of South Carolina)**
**Research Aims:** The mission of the Medical University of South Carolina Digestive Disease Research Core Center (MUSC DDRCC) is to enhance research infrastructure and expand research capacity to enable outstanding, collaborative biomedical research in digestive and liver diseases.
    **Activities & Services**
    Cores
        Analytical Cell Models
            Advanced Imaging
            Proteomics
            Clinical Component
    Pilot & Feasibility Program
    Through Pilot and Feasibility project funding, attract and support junior investigators into the field. The P & F project additionally is expected to attract those who are not currently involved in digestive disease research to apply their expertise to this important area and help translate basic research discoveries to the clinical arena.**San Diego Digestive Diseases Research Center (SDDRC)** draws on the ever-expanding biomedical research enterprise in the San Diego area, and the opportunity to select a unique subset of academic investigators for Center membership, whose work complements the thematic focus of the Center on "Inflammation in the Digestive Tract." Center investigators conduct outstanding research related to inflammation, immunity, and host-microbial interactions in both gastrointestinal tract and liver. Topics range from basic mechanisms governing inflammation, the role of infection, immune and inflammatory responses in preclinical studies, to translational studies and clinical trials with human tissues and well-defined patient populations.
**Research Aims:** The aim of the research training program is to develop independent investigators who will devote their career to research on fundamental aspects of digestive diseases and train individuals from the adult and pediatric GI programs.
    **Activities & Services** 
    Cores
        Human Translational Core
            Preclinical Models
            Microbiomics and Functional Genomics
    Pilot & Feasibility Program 
    The SDDRC Pilot and Feasibility Program provides financial and mentoring support to facilitate and accelerate the development of innovative ideas in digestive disease research.**Pittsburgh Liver Research Center****(University of Pittsburgh)**
**Research Aims:** The Pittsburgh Liver Research Center (PLRC) is a multidisciplinary center that builds on the strengths of UPMC, a leader in the delivery of innovative and cutting-edge clinical care, and the University of Pittsburgh, a leader in research, discovery, education, and innovation. Serving as a point of convergence for timely research in liver health and disease, PLRC fosters an intellectual exchange between clinicians and researchers to management of patients with liver disease. The PLRC is committed to providing a platform to enhance, enrich, and synergize scientific interactions and collaborations among various investigators in the field of liver pathobiology in three major areas - Regenerative Medicine, Chronic Liver Injury and Tumorigenesis. Specifically, the PLRC provides research funding, scientific and clinical core facilities, opportunities to network and collaborate, and education.
    **Activities & Services** 
    **Administrative Core**
        Administrative core provides administrative leadership while seeking advice from the PLRC membership, External and Internal Advisory Boards.
        **Scientific Cores**
        Advanced Cell and Tissue Imaging Center
            Clinical Biospecimen Repository and Processing Core
            Genomics and Systems Biology Core
            Human Synthetic Liver Biology Core
        Pilot and Feasibility Program
        PLRC sponsors Pilot and Feasibility grants every year to especially support new investigators in liver related research projects, and provide longitudinal mentoring and career development opportunities.
        Enrichment Program
        The enrichment program fosters community building while providing various opportunities of enrichment through seminars, work-in-progress meetings, clinician-scientist round tables, mini-retreats, and workshops.**Texas Medical Center Digestive Diseases Center (Baylor College of Medicine)**
**Research Aims:**Facilitates cutting-edge digestive diseases research, promotes collaborative translational research between basic and clinical areas, develops new projects, nurtures new investigators, and provides GI educational activities.
    **Activities & Services**
    Cores
        Administrative
            Cellular and Molecular Morphology
            Functional Genomics and Microbiome Integrative Biology
            Gastrointestinal Experimental Models Systems (GEMS)
            Study Design and Clinical Research
        Pilot & Feasibility Program
        Supports pilot/feasibility (P/F) projects related the theme of GI Infection and Injury.**UNC Center for Gastrointestinal Biology and Disease (University of North Carolina)**
**Research Aims:**The mission of the CGIBD is to promote and enhance multidisciplinary research to reduce the burden of digestive diseases.
    **Activities & Services**
    Cores
        Advanced Analytics
            Biostatistics and Data Management
            Gnotobiotic
            Large Animal Models
        Pilot & Feasibility Program
        Proposed research must relate to digestive diseases.**UCSF Liver Center (University of California San Francisco)**
**Research Aims:**The mission of the Center is to enable scientific discovery and exchange to improve the lives of patients with liver disease.
    **Activities & Services**
    Cores
        Liver Cell Isolation, Analysis and Immunology Core
            Liver Tissue Analysis Core
            Liver Gene Analysis Core
            Patient-Facing Research Core
        Pilot & Feasibility Program
        The Pilot/Feasibility Award Program provides seed money to investigators who are attempting to launch new liver-related research projects. The goal of the program is to enable investigators to test new hypotheses and obtain preliminary data that can ultimately be expended into a large grant application.**University of Chicago Center for Interdisciplinary Study of Inflammatory Intestinal Disorders (University of Chicago)**
**Research Aims:**To foster and facilitate interdisciplinary and innovative, patient-oriented, research in the field of complex inflammatory digestive diseases, to understand and therapeutically exploit discoveries to improve the health of patients with digestive diseases.
    **Activities & Services**
    Cores
        Integrative Clinical and Biospecimen Core
            Host-Microbe Core
            Tissue Engineering and Cell Models Core
            Multiparametric Host Cell Analysis Core
        Pilot & Feasibility Program
        Program aimed at funding early stage investigators (principal target group), established faculty outside of gastrointestinal research who wish to extend their investigations into the mission of the C-IID and faculty conducting research in digestive health and diseases. Proposals that involve studies of inflammatory bowel diseases and related areas of intestinal inflammation, the gut immune system, the gut microbiome, host-microbe interactions, microbiome-based biotherapeutics, hepatic and digestive functions, host-microbe metabolism, and epithelial biology/developmental regulation of the gut will be given special consideration.**Vanderbilt Digestive Disease Research Center (Vanderbilt University Medical Center)**
**Research Aims:**The DDRC is a multidisciplinary center at Vanderbilt University Medical Center developed to serve the following purposes:
    Promote digestive diseases-related research in an integrative, collaborative, diverse, supportive, and multidisciplinary manner
        Develop and implement programs for attracting, training, and retaining young and diverse investigators in digestive disease-related research
        Enhance the basic, translational, and clinical research capabilities of the VDDRC members
        Facilitate the transfer of basic research discoveries to improvements in prevention and/or clinical care
        Attract investigators not involved in digestive disease-related research to pursue these lines of investigation
    **Activities & Services**
    Cores
        Mass Spectrometry/Proteomics Core
            Cell Imaging Core
            Flow Cytometry Core
            Translational Analysis Core
            Biostatistics Component
        Pilot & Feasibility Program
        Provides Vanderbilt investigators the opportunity to explore nascent, meritorious hypotheses related to digestive diseases with the ultimate goal being acquisition of external funding and publication of new knowledge**Washington University Digestive Diseases Research Core Center (Washington University at St. Louis)**
**Research Aims:**The overarching mission of the Center is to promote collaborative, multidisciplinary research focused on interactions between host and environment in digestive disease. Our Center seeks to advance the health of patients with digestive diseases by supporting enabling technology and promoting the basic and translational research interests of its Full and Associate members, while nurturing the career development of junior investigators. Interests are organized around three major themes:
    Host-microbial interactions, inflammation and mucosal immunity
        Stem cells, epithelial renewal, paligenosis and cancer;
        Metabolic homeostasis, nutrient transport and enterohepatic signaling
    **Activities & Services**
    Cores
        Administrative and Resource Access Core
            Advanced Imaging & Tissue Analysis Core
            Biobank Core
            Precision Animal Models and Organoids Core
        Pilot & Feasibility Program
        This program hopes to encourage young investigators and more established investigators in other field to approach problems which are relevant to our understanding of normal intestinal, liver and pancreatic function and to digestive diseases. We are particularly interested in projects that address issues in mucosal immunity, epithelial injury/repair, microbial interactions with intestinal, hepatic and pancreatic tissues. We would like to encourage efforts addressing intestinal motility and the application of novel genetic models (e.g. C. elegans, Drosophilia, etc) to address questions in GI tract development.**Yale Liver Center (Yale University)**
**Research Aims:** The Yale Liver Center's mission is to enhance knowledge of the etiology, diagnosis and treatment of liver diseases and other related disorders of the digestive system, thereby advancing the nation's public health. It does so by stimulating basic, translational, and clinical research in this discipline at the University and by establishing core research facilities for use by multiple liver
    investigators.
    **Activities & Services:**
    Cores
        Administrative Core
            Cellular and Molecular Physiology Core
            Morphology Core Facility
            Clinical and Translational Core
        Pilot & Feasibility Program
        The Pilot Feasibility Program seeks to introduce new investigators and ideas to the Liver Center, to promote novel ideas that may advance the field of hepatology, and to enable investigators to obtain data for future grant submissions, such as R01 applications.
        Enrichment Program
        The Enrichment Program provides opportunities for education and networking for the Liver Center members through a regular seminar series, an annual retreat, a ‘reverse mini-sabbatical’ program that brings visiting professors to the Center for a period of at least one month, a newsletter, and certain special scientific and educational programs.
Related Links
Digestive Diseases Research Centers
    NIDDK Active Trials in Digestive Disease
    View related clinical trials from ClinicalTrials.gov.
    NIH Study Sections
    Study sections conduct initial peer review of applications in a designated scientific area.
    Visit the NIH’s Center for Scientific Review website to search for study sections.Research Resources

NIDDK makes publicly supported resources, data sets, and studies available to researchers to accelerate the rate and lower the cost of new discoveries.
Ancillary Studies to Major Ongoing Clinical Studies to extend our knowledge of the diseases being studied by the parent study investigators under a defined protocol or to study diseases and conditions not within the original scope of the parent study but within the mission of the NIDDK.
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The NIDDK offers and participates in a variety of opportunities for trainees and researchers from communities underrepresented in the biomedical research enterprise. These opportunities include travel and scholarship awards, research supplements, small clinical grants, high school and undergraduate programs, and a network of minority health research investigators.
Learn about NIDDK Diversity Programs
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These programs support innovative research conducted by small businesses that has the potential for
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Human Subjects Research
NIDDK provides funding for pivotal clinical research, from preliminary clinical feasibility to large multi-center studies.
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NIDDK provides funding opportunities and resources to encourage translation of basic discoveries
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        Last Reviewed April 2023 Contact Us
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