## Contact Information

Bethesda MD20892

keiko.sakamoto@nih.gov

## Media Resources

sakamoto-headshot.jpg

## Summary

Keiko Sakamoto, M.D., Ph.D., is a board-certified Dermatologist (Japanese Association of Dermatology) and Stephen I. Katz Scholar in the Cutaneous Leukocyte Biology Section at the National Institute of Arthritis and Musculoskeletal and Skin Diseases. 

Dr. Sakamoto obtained her M.D. from Kagawa University Faculty of Medicine and Ph.D. from Hamamatsu University School of Medicine. She was a visiting fellow in the Nagao lab, Dermatology Branch, NIAMS, NIH from 2018 to 2021. After serving as faculty in the Department of Dermatology at Hamamatsu University School of Medicine, she returned to the NIH in 2023.

## Research Statement

Dr. Sakamoto explores mechanisms that underlie cell-cell communication in the skin during homeostasis and disease. In 2021, she demonstrated that the Notch-ADAM10 signaling axis in the interferon-responsive hair follicles were required for regulating follicular microbiome, the disruption of which led to follicular dysbiosis and innate lymphoid cell-mediated destruction of the hair follicles (Sakamoto et al., *Immunity* 2021), modeling a form of scarring alopecia. Upon her return, she continues to study immune cell-tissue crosstalk in the context of basic skin immunology and human primary immunodeficiencies.

## Scientific Publications

###             A case of nonpigmented fixed-drug eruption with eosinophilic intraepidermal vesicle formation.        

51(4).

###             Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function.        

8(89).

###             Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin.        

56(7).

###             Mouse Models for Atopic Dermatitis.        

3(3).

###             Identification of skin-infiltrating donor lymphocytes in a case of pre-engraftment syndrome.        

50(9).

###             T cell-rich perivascular inflammation in a case of cutaneous variant intravascular large B-cell lymphoma.        

49(12).

###             The Double-Stranded RNA Analog, Poly(I:C), Triggers Distinct Transcriptomic Shifts in Keratinocyte Subsets.        

142(10).

###             A case of methotrexate-associated Epstein-Barr virus-positive mucocutaneous ulcer.        

2(2).

###             Flow cytometry analysis of the subpopulations of mouse keratinocytes and skin immune cells.        

3(1).

###             Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction.        

54(10).

###             Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report.        

26(2).

###             Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen.        

116(29).

## Education

Kagawa University Faculty of Medicine (M.D.)

Hamamatsu University School of Medicine (Ph.D.)

## Experience

Stephen I. Katz Scholar (Senior Research Fellow), Nagao Lab, Dermatology Branch, NIAMS, National Institute of Health (2023 – current)

Assistant Professor, Department of Dermatology, Hamamatsu University School of Medicine (2022) 

Attending Physician, Department of Dermatology, Hamamatsu Medical Center (2021) 

Visiting Fellow, Nagao Lab, Dermatology Branch, NIAMS, National Institute of Health (2019) 

Special Volunteer, Nagao Lab, Dermatology Branch, NIAMS, National Institute of Health (2018) 

Director, Department of Dermatology, Iwata City Hospital (2016) 

Attending Physician, Department of Dermatology, Iwata City Hospital (2008) 

Clinical Fellow, Hamamatsu University School of Medicine (2007) 

Resident, Hamamatsu Medical Center (2005) 

Resident, Department of Dermatology, Hamamatsu University School of Medicine (2004)

March 2024

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