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          NIAMS Update
          NIAMS Update
          NIAMS Update, Issue 2, 2021


NIAMS Update


NIAMS Update, Issue 2, 2021


Ending Structural Racism in Biomedical Research Starts Now *April 29, 2021*
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    NEWS

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              Profile picture of Dr. Criswell

*Lindsey A. Criswell, M.D., M.P.H., D.Sc.***From the Director: *Ending Structural Racism in Biomedical Research Starts Now***

National Institutes of Health (NIH) Director Francis S. Collins, M.D., Ph.D., recently declared that NIH stands against structural racism in biomedical research. Adding action to words, he announced a new NIH initiative called UNITE and unveiled a website on Ending Structural Racism. I strongly support these efforts and join Dr. Collins in what is unquestionably a long overdue condemnation of racial inequity in biomedical science.





**Fiscal Year (FY) 2021 Funding Plan (Updated April 22, 2021)**

The NIAMS is operating under the FY 2021 Consolidated Appropriations Act. The NIAMS FY 2021 Enacted Level is $634,292,000.

**COVID-19 Updates**

Get the latest public health information from the Centers for Disease Control and Prevention, and the latest research information from the NIH. Additional news and resources include:

Infections With “U.K Variant” B.1.1.7 Have Greater Risk of Mortality (NIH Director's Blog)
	NIH Effort Seeks to Understand MIS-C, Range of SARS-CoV-2 Effects on Children
	NIH Study Finds That People With SARS-CoV-2 Antibodies May Have a Low Risk of Future Infection
	T Cells Recognize Recent SARS-CoV-2 Variants
	NIH Clinical Trial Evaluating Moderna COVID-19 Variant Vaccine BeginsImage
              Ending Structural Racism


**NIH Stands Against Structural Racism in Biomedical Research**

NIH Director Francis S. Collins, M.D., Ph.D., announced the launch of UNITE, a new NIH initiative aimed at bringing an end to structural racism and racial inequalities in biomedical research.







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              NIH Directors Image


**NIH Director’s Blog:*****Could CRISPR Gene-Editing Technology Be an Answer to Chronic Pain?***

Recently published research on mice demonstrated that a modified version of the CRISPR system can be used to “turn off” a gene in critical neurons—thereby blocking the transmission of pain signals.

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              NIH Medline Plus Image


**NIH MedlinePlus Magazine: *How to Manage Low Back Pain Before It Gets Worse***

Jonathan Lurie, M.D., a physician-researcher who conducts NIAMS-supported research, offers some suggestions for people with low back pain on how they can manage it before it gets worse.





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              NIH Engineered Catilage image


**Engineered Cartilage Produces Anti-Inflammatory Drug**

In a study funded in part by the NIAMS, scientists engineered cartilage cells to produce an anti-inflammatory drug when placed under stress. The drug blocked the destructive effects of inflammation. These results demonstrate the ability to engineer living tissue to produce its own therapeutic drugs.



**NIAMS Special Awards Announcement**

The NIAMS’ John O’Shea, M.D., was awarded the 2021 Harrington Prize for Innovation in Medicine.

FDA News

U.S. Food and Drug Administration (FDA) Approves First in the World, First-of-Its-Kind Implant for the Treatment of Rare Bone Disease as a Humanitarian Use Device
	FDA Approves Targeted Treatment for Rare Duchenne Muscular Dystrophy MutationFUNDING OPPORTUNITIES

**Accelerating Medicines Partnership: *Autoimmune and Immune-Mediated Diseases (AMP AIM)*** *(**RFA-AR-21-015**and RFA-AR-21-016)*

**AMP AIM: *Disease Teams for Rheumatoid Arthritis, Lupus, Psoriatic Spectrum Diseases, and Sjögren’s Syndrome (UC2 Clinical Trial Optional)****(RFA-AR-21-015)*
	**AMP AIM: *Technology and Analytic Cores and Research Management Unit (UC2 Clinical Trial Not Allowed)****(RFA-AR-21-016)***Centers for Multiple Chronic Diseases Associated With Health Disparities: *Prevention, Treatment, and Management (P50 Clinical Trial Required)****(RFA-MD-21-007)*

**NIMHD Multiple Chronic Disease Disparities Research Coordinating Center (RCC) (U24 Clinical Trial Not Allowed)** (RFA-MD-21-008)

**Notice of Special Interest (NOSI):*Research to Address Vaccine Hesitancy, Uptake, and Implementation Among Populations That Experience Health Disparities*** *(NOT-MD-21-008)*

This NOSI highlights the need for research strategies and interventions to address vaccine hesitancy, uptake, and implementation among populations who experience health disparities in the United States.

Stay Updated About Funding Announcements

If you would like information about grants and funding opportunities, subscribe to funding-dedicated email newsletters, including periodic *NIAMS Funding Alerts*and a monthly *NIAMS Funding News* email, and follow our new Twitter account (@NIAMSFunding) focused on funding opportunities. Also check out the NIH Guide for Grants and Contracts, the primary source for information about NIH funding opportunities. You can also request a weekly Table of Contents from the NIH Guide. In addition, the NIAMS website provides comprehensive information on NIAMS-related grants and processes.

RESOURCES



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              Mouse Imagery


**Spotlight on Scientific Imagery: *Mouse Hair Follicles and Regulatory T Cells***

This is a microscopic image of mouse hair follicles, stained green. Regulatory T cells (red dots) are located next to the follicles. Researchers have discovered that these T cells, part of the immune system, trigger stem cells in the skin to promote hair growth. Defects in regulatory T cells may be involved in hair loss, such as that which occurs in alopecia areata.

*Photo credit:* *Michael Rosenblum, M.D., Ph.D., University of California San Francisco*

**NIAMS Forum for Clinical Mentored K Awardees—December 2020**

The Forum featured research presentations by the investigators in the third or fourth year of their K award. The scientists briefly outlined their research projects and progress. Read a summary of the event here.

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              Image of hands


***NIH News in Health:******Patchy Skin******, Vitiligo Explained***

In this feature story about vitiligo, NIAMS-supported researcher John E. Harris, M.D., Ph.D., comments on symptoms, quality of life, current treatments, and why “targeted therapies” may hold more promise than drugs that suppress the immune system.





EVENTS

**May NIAMS Advisory Council Meeting (Virtual Meeting)**

The next NIAMS Advisory Council Meeting will be held May 18, 2021. This meeting will be available for viewing via the NIH videocasting service.



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              video Image




**Healing the Opioid Crisis With Mindfulness-Oriented Recovery Enhancement (MORE): *Clinical Efficacy and Neurophysiological Mechanisms***

May 4, 2021
12 to 1 p.m. ET
Event will be videocast.

**Fifth Annual Vivian Pinn Symposium—NIH Office of Research on Women’s Health**

May 11‒12, 2021
10 a.m. to 7 p.m. ET each day
Event will be videocast.

**2021 NIH Pain Consortium: *Pain and Pandemics—Challenges and Opportunities in the Current Social and Healthcare Climate***

May 24‒25, 2021
Final details about this meeting are pending.Registration is required.

**Cooperative Pain Education and Self-Management (COPES): *A Technology-Assisted Intervention for Pain***

June 8, 2021
12 to 1 p.m. ET
Event will be videocast.

**NIH Director’s Wednesday Afternoon Lecture Series**

**Upcoming Lectures:**

May 5, 2021
2 to 3 p.m. ETNIH Director’s Lecture
Hugh Herr, Ph.D., Massachusetts Institute of Technology**On the Design of Bionic Limbs: *The Science of Tissue-Synthetic Interface***

May 19, 2021
3 to 4 p.m. ETNIH Director’s Lecture
Eric Topol, M.D., Scripps Research Institute**The AI Path to Deeper and More Accurate Medicine**

June 9, 2021
3 to 4 p.m. ETG. Burroughs Mider Lecture
Mariana J. Kaplan, M.D., NIAMS**Casting the Net Wide: *The Role of Neutrophils in Chronic Diseases***

The NIH Director’s Wednesday Afternoon Lecture Series offers weekly lectures every Wednesday. Renowned scientists from around the globe present research weekly on a variety of topics. The lectures are continuing medical education certified, open to the public and available live via webcast.

*For additional online science seminars and events hosted by the NIH, view the**NIH Videocast Future Events**and the**NIH calendar*. 
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