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		Search Text: Home/< Back ToThe Science/Cardiovascular Intervention
  Cardiovascular Intervention
    The Laboratory of Cardiovascular Intervention, led by Dr. Robert J. Lederman, creates new catheter based treatments and devices for structural heart disease and introduces them into medical practice. The lab is a multidisciplinary team of cardiologists (adult and pediatric), imaging scientists, and catheter engineers. The lab has close collaborations with luminary cardiologists across the USA and the world.
Dr. Lederman and his team invented a growing list of techniques and devices and helped introduce them into patients for the first time. More are in advanced development. In addition, Dr. Lederman’s program leads an international effort to use real-time magnetic resonance imaging (MRI) to guide catheter procedures in patients.
    On This Page
    
          profile
  Robert Lederman, M.D.
          Senior Investigator
          Email
      Meet the Team
            Contact us
  Senior Investigator Research Interests
            
  Research Interests
              Dr. Robert Lederman is a practicing interventional cardiologist with experience in early phase human device clinical protocols who has worked for over a decade at the NHLBI intramural research program developing new non-surgical devices and image guidance to treat cardiovascular disease. Now a tenured investigator, Dr. Lederman leads a team of adult and pediatric interventional cardiologists, engineers, and physicists that has developed completely new approaches to cardiac structural intervention oriented around real-time MRI and X-ray. His team has introduced MRI hemodynamic catheterization into standard clinical practice at the NIH Clinical Center. Through CRADA partnerships, image guidance technology has been developed into commercial clinical prototypes, including MRI and X-ray co-registration to enhance conventional interventional procedures, and including a real-time MRI user interface now in routine clinical use.

Dr. Lederman's group and collaborators have conceived and translated several completely new transcatheter structural heart interventional procedures into patients, including transcaval access for TAVR, mitral cerclage annuloplasty, intentional laceration of the anterior mitral leaflet to prevent LVOT obstruction during TMVR (LAMPOON) and to release Mitraclips (ELASTACLIP), intentional laceration of the aortic leaflets to prevent coronary obstruction after TAVR (BASILICA), pledget assisted suture tricuspid annuloplasty (PASTA), transcatheter superior cavopulmonary (Glenn) shunt, and others not yet reported. The team collaborates closely with luminary cardiologists across the country to bring solutions to patients without good clinical options. They have shepherded these projects from conception, to prototyping, to in vivo testing, to compassionate human use, to systematic IDE investigation in patients, and in some cases to broad dissemination and education. They have a pipeline of new techniques, devices, and clinical research protocols under development to address right- and left-ventricular failure, tricuspid and mitral valve regurgitation, bioprosthetic failure, and congenital heart disease.
  Treatments and Devices

            We create new catheter based treatments and devices for structural heart disease and introduce them into medical practice.

We are a multidisciplinary team of cardiologists (adult and pediatric), imaging scientists, and catheter engineers. We have close collaborations with luminary cardiologists across the USA and the world.

We have a growing list of techniques and devices that we have invented and helped to use in humans for the first time. Many more are in advanced development.
      
Learn more
Clinical Trials and Studies
Right Heart Catheterization Using Magnetic Resonance Imaging Fluoroscopy and Passive Guidewires
				Recruiting
											
											Adult, Older Adult
					
											All Genders
					
																		Not Accepting Healthy Volunteers

				Has your doctor recommended right heart cardiac catheterization for you?
												This study is investigating new magnetic resonance imaging (MRI) techniques that use a guidewire to help position a heart catheter within the heart. MRI fluoroscopy shows pictures of the heart so that doctors can watch while they work. Using the guidewire during MRI may improve the procedure of heart catheterization. To participate in this study, you must be at least 18 years old, and your doctor must have recommended right heart catheterization for you. This study is located in Bethesda, Maryland.NHLBI Transmural Electrosurgery LeafLet Traversal And Laceration Evaluation (TELLTALE) BASILICA-TAVR Trial
				Recruiting
											
											Adult, Older Adult
					
											All Genders
					
																		Not Accepting Healthy Volunteers

				Are you at least 18 years old and have been told by your doctor that you need a procedure called transcatheter aortic valve replacement?
												This study will test a new device designed specifically for use during a procedure called transcatheter aortic valve replacement. Researchers want to make transcatheter aortic valve replacement safer. To be in the study, you must be at least 18 and need a transcatheter aortic valve replacement. The study will take place in locations in California, Georgia, Massachusetts, New York, Virginia, Washington, and Washington, D.C.
Featured Publications
                BASILICA Trial: One-Year Outcomes of Transcatheter Electrosurgical Leaflet Laceration to Prevent TAVR Coronary Obstruction.
            Authors:Khan JM, Greenbaum AB, Babaliaros VC, Dvir D, Reisman M, McCabe JM, Satler L, Waksman R, Eng MH, Paone G, Chen MY, Bruce CG, Stine AM, Tian X, Rogers T, Lederman RJ.
                                                                                                                        
            Circ Cardiovasc Interv.
      
                2021 May 01;14(15):e010238
        Read Publication
                      Anterior Leaflet Laceration to Prevent Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Replacement.
            Authors:Khan JM, Babaliaros VC, Greenbaum AB, Foerst JR, Yazdani S, McCabe JM, Paone G, Eng MH, Leshnower BG, Gleason PT, Chen MY, Wang DD, Tian X, Stine AM, Rogers T, Lederman RJ.
                                                                                                                        
            J Am Coll Cardiol. 
      
                2019 May 28;73(20):2521-2534
        Read Publication
                      The Fate of Transcaval Access Tracts: 12-Month Results of the Prospective NHLBI Transcaval Transcatheter Aortic Valve Replacement Study.
            Authors:Lederman RJ, Babaliaros VC, Rogers T, Stine AM, Chen MY, Muhammad KI, Leonardi RA, Paone G, Khan JM, Leshnower BG, Thourani VH, Tian X, Greenbaum AB.
                                                                                                                        
            JACC Cardiovasc Interv.
      
                2019 May 11;12(5):448-456
        Read Publication
                      Transatrial intrapericardial tricuspid annuloplasty.
            Authors:Rogers T, Ratnayaka K, Sonmez M, Franson DN, Schenke WH, Mazal JR, Kocaturk O, Chen MY, Faranesh AZ, Lederman R
                                                                                                                        
            JACC Cardiovasc Interv
      
                2015 Mar 01;8(3):483-91
        Read Publication
                      Mitral cerclage annuloplasty, a novel transcatheter treatment for secondary mitral valve regurgitation: initial results in swine.
            Authors:Kim JH, Kocaturk O, Ozturk C, Faranesh AZ, Sonmez M, Sampath S, Saikus CE, Kim AH, Raman VK, Derbyshire JA, Schenke WH, Wright VJ, Berry C, McVeigh ER, Lederman RJ
                                                                                                                        
            J. Am. Coll. Cardiol.
      
                2009 Aug 11;54(7):638-51
        Read Publication
                                View More Publications
  Meet the Team

    profile

            Robert Lederman, M.D.
                Senior Investigator
                Robert Lederman received his B.S. in molecular biophysics and biochemistry from Yale University in 1986 and his M.D. from Case Western Reserve University (CWRU) in 1990. He was a resident and chief resident in medicine at CWRU. He completed fellowships in cardiology (University of California, San Francisco, 1994), interventional cardiology (University of Michigan, 1996), and peripheral vascular intervention (Duke University, 1997). He was assistant professor in interventional cardiology at University of Michigan (1998-2000). He joined the NHLBI as an Investigator in the Cardiovascular Branch in 2000 to begin work in interventional cardiovascular MRI and was named a Senior Investigator (with tenure) in 2008. He has authored or coauthored more than 200 papers or book chapters. Dr. Lederman is a Fellow of the American College of Cardiology, the American Heart Association, the Society for Cardiovascular Angiography and Intervention, and a member of the Society for Cardiovascular Magnetic Resonance Imaging. He has over two dozen patents issued or pending for his work. His lab has created over a dozen new catheter-based treatments or devices for structural heart disease.
    
          Contact the lab
    10 Center DrBethesda, MD 20814United States
        Phone:
                    301-402-6769
                Fax:
            301-451-5451
  Daniel Herzka
    
            Daniel A.  Herzka, Ph.D.
        

    Staff Scientist, MRI Physics

        daniel.herzka@nih.gov
            Christopher Bruce
    
            Christopher G.  Bruce, MB ChB
        

    Staff Clinican, Adult Interventional Cardiologist

        christopher.bruce2@nih.gov
            Toby Rogers
    
            Toby Rogers, BM BCh, Ph.D.
        

    Staff Clinician, Adult Interventional Cardiologist (Medstar Washington Hosp Ctr)

        toby.rogers@nih.gov
        
                    View
                    Toby's Profile
            Jaffar Khan
    
            Jaffar M.  Khan, BM BCh
        

    Staff Clinician, Adult Interventional Cardiologist

        jaffar.khan@nih.gov
            kanishka
    
            Kanishka Ratnayaka, M.D.
        

    Pediatric Interventional Cardiologist (UCSD Rady Children's Hospital)

        kanishka.ratnayaka@nih.gov
        
                    View
                    Kanishka's Profile
            kolandaivelu
    
            Aravindan  Kolandaivelu, M.D.
        

    Adult Cardiac Electrophysiologist (Johns Hopkins University)

        View
                    Aravindan 's Profile
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            Annette M.  Stine, RN
        

    Research Manager

        stinea@nhlbi.nih.gov
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            Laurie P. Grant, RNP, RN
        

    Nurse Practitioner

        grantlp@nhlbi.nih.gov
            blank avatar
    
            Sowmya Sreekanth, M.D.
        

    Regulatory Manager

        sowmya.sreekanth@nih.gov
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            William H.  Schenke
        

    Interventional X-Ray Technologist

        schenkeb@nih.gov
            blank avatar
    
            Andi  Jaimes
        

    Interventional X-Ray Technologist

        andi.jaimes@nih.gov
            Kendall
    
            Kendall O'Brien
        

    Interventional MRI Technologist

        kendall.o'brien@nih.gov
            D. Korel Yildirim
    
            D. Korel Yildirim, MS
        

    Catheter Prototyping Engineer

        korel.yildirim@nih.gov
            Dogangun Uzun
    
            Dogangun  Uzun, MS
        

    Catheter Prototyping Engineer

        dogangun.uzun@nih.gov
            blank avatar
    
            Luis Rosario
        

    Patient Care Coordinator

        rosariol@mail.nih.gov
            blank avatar
    
            Rachel Reed
        

    Administrative Assistant

        rreed@nih.gov
            Ozgur Kocaturk
    
            Ozgur Kocaturk, Ph.D.
        

    Collaborating MRI Catheter Engineer

        kocaturko@mail.nih.gov
            Adrienne Campbell-Washburn
    
            Adrienne Campbell-Washburn, Ph.D.
        

    Collaborating MRI Physicist

        adrienne.campbell@nih.gov
        
                    View
                    Adrienne's Profile
            greenbaum
    
            Adam  Greenbaum, M.D.
        

    Collaborating Adult Interventional Cardiologist (Emory University)

        adam.b.greenbaum@emory.edu
        
                    View
                    Adam 's Profile
            babaliaros
    
            Vasilis  Babaliaros, M.D.
        

    Collaborating Adult Interventional Cardiologist (Emory University)

        vbabali@emory.edu
        
                    View
                    Vasilis 's Profile
            Vandana Sachdev
    
            Vandana Sachdev, M.D.
        

    Collaborating Echocardiographer, NHLBI

        sachdevv@nhlbi.nih.gov
        
                    View
                    Vandana's Profile
            Marcus Chen
    
            Marcus Y. Chen, M.D.
        

    Collaborating Cardiac CT, NHLBI

        chenmy@mail.nih.gov
        
                    View
                    Marcus's Profile
            Carlsson
    
            Marcus  B. Carlsson, M.D.
        

    Collaborating Cardiac MRI

        marcus.carlsson@nih.gov
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  Alumni
        

June-Hong  Kim, M.D.
        

    Adult Interventional Cardiologist
        June-Hong  Kim, M.D. is currently a Professor at Pusan National University, Republic of Korea.
      Kanishka Ratnayaka, M.D.
        

    Pediatric Interventional Cardiologist
        Kanishka Ratnayaka, M.D. is currently a Associate Professor at UCSD Rady Children's Hospital.
      Christina E. Saikus, Ph.D., M.D.
        

    Cardiovascular Surgery
        Christina E. Saikus, Ph.D., M.D. is currently at Cleveland Clinic Foundation.
      Israel M. Barbash, M.D.
        

    Adult Interventional Cardiologist
        Israel M. Barbash, M.D. is currently a Associate Professor at Sheba Medical Center, Tel Aviv University, Israel.
      Jamie (Bell) Jarmul, M.D.
        

    Research Fellow
        Jamie (Bell) Jarmul, M.D. is currently at University of North Carolina School of Medicine.
      Majdi Halabi, M.D.
        

    Adult Interventional Cardiologist
        Majdi Halabi, M.D. is currently at Ziv Medical Center, Bar Ilan University, Israel.
      Dominique N. Franson
        

    MRI Physicist
        Dominique N. Franson  is currently a Ph.D. Candidate at Case Western Reserve University.
      Elena Grant Amin, MB ChB
        

    Pediatric Interventional Cardiologist
        Elena Grant Amin, MB ChB is currently at Ziv Medical Center, Bar Ilan University, Israel.
      Rajiv Ramasawmy, Ph.D.
        

    MRI Physicist
        Rajiv Ramasawmy, Ph.D. is currently a Staff Scientist at NHLBI.

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