**Exhibit 24.1**

 

**Power of Attorney**

 

**Know All Persons By These Presents**, that each person whose signature appearsbelow constitutes and appoints Gordon H. Link, Jr., Kai Larson, and BruceFiedler, and each or any one of them, his true and lawful attorney-in-fact andagent, with full power of substitution and resubstitution, for him and in hisname, place and stead, in any and all capacities, to (i) sign the annualreport on Form 10-K filed by Tapestry Pharmaceuticals, Inc. (the “Company”)for the fiscal year ended December 28, 2005 and (ii) sign any and allamendments to the Form 10-K, and to file the same, with all exhibitsthereto, and other documents in connection therewith, with the Securities andExchange Commission, granting unto said attorneys-in-fact and agents, and eachof them, full power and authority to do and perform each and every act andthing requisite and necessary to be done in connection therewith, as fully toall intents and purposes as he might or could do in person, hereby ratifyingand confirming all that said attorneys-in-fact and agents, or any of them, ortheir or his substitutes or substitute, may lawfully do or cause to bedone by virtue hereof.

 
| **Signature**                      | ** ** | **Title**                                                  | ** ** | **Date**                          |
|------------------------------------|------------|------------------------------------------------------------|------------|-----------------------------------|
| ** **                         | ** ** | ** **                                                 | ** ** | ** **                        |
|                               |       | Chairman of the Board   Chief Executive Officer   Director |       | February   ,  2006 |
| Leonard P. Shaykin                 |       |                                                       |       |                              |
|                               |       |                                                       |       |                              |
| /s/ Patricia  A. Pilia             |       | Executive Vice President   Director                        |       | February 16, 2006            |
| Patricia A. Pilia, Ph.D.           |       |                                                       |       |                              |
|                               |       |                                                       |       |                              |
| /s/ Stephen K. Carter              |       |                                                       |       |                              |
| Stephen K. Carter, M.D.            |       | Director                                                   |       | February 15, 2006            |
|                               |       |                                                       |       |                              |
| /s/ George Gould                   |       |                                                       |       |                              |
| George Gould, Esq.            |       | Director                                                   |       | February 14, 2006            |
|                               |       |                                                       |       |                              |
| /s/ Arthur Hull Hayes              |       |                                                       |       |                              |
| Arthur Hull Hayes, Jr.,  M.D. |       | Director                                                   |       | February 17, 2006            |
|                               |       |                                                       |       |                              |
| /s/ Elliot M. Maza                 |       |                                                       |       |                              |
| Elliot M. Maza, Esq.          |       | Director                                                   |       | February 19, 2006            |
|                               |       |                                                       |       |                              |
| /s/ Richard N. Perle               |       |                                                       |       |                              |
| The Honorable Richard N.  Perle    |       | Director                                                   |       | February 15, 2006            |
|                               |       |                                                       |       |                              |
| /s/ Robert E. Pollack              |       |                                                       |       |                              |
| Robert E. Pollack, Ph.D.           |       | Director                                                   |       | February 14, 2006            |

 

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