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          About NIAMS
          Leslie Castelo-Soccio, M.D., Ph.D.





Leslie Castelo-Soccio, M.D., Ph.D.


Staff Clinician
    Dermatologist, Cutaneous Microbiome and Inflammation Section
    Attending Physician, Dermatology Branch Image
              Leslie Castelo-Soccio, M.D., Ph.D. 
            Contact Information

                                
                                                10 Center Drive
                  
            Building 10, Room 13C429
      
                  
                                   Bethesda MD 20892
                
                                                leslie.castelo-soccio@nih.gov 
                Summary
          Leslie Castelo-Soccio, M.D., Ph.D. received her undergraduate degree from Harvard University and her medical and doctoral degrees from the Tri-Institutional MD-PhD program at Cornell University.  After training in dermatology at the University of Pennsylvania, she completed a pediatric dermatology fellowship at the Children's Hospital of Philadelphia and a post-doctoral fellowship in the laboratory of George Cotsarelis, M.D. at the University of Pennsylvania. From 2011-2021, Dr. Castelo-Soccio was an assistant professor of pediatrics and dermatology at the University of Pennsylvania Perelman School of Medicine and also the research director and an attending physician in pediatric dermatology at the Children's Hospital of Philadelphia.

She currently serves as co-director of the Hair Disorders Focus Study Group for the Pediatric Dermatology Research Alliance and is an attending physician on the NIH Dermatology Consultation Service.
        
                  Research Statement
          
            Dr. Castelo-Soccio's research covers the natural history of pediatric alopecia areata including epidemiology, associated co-morbidities, and response to therapy. She specializes in the use of imaging tools and develops guidelines for pediatric alopecia. Dr. Castelo-Soccio also studies the microbiome of hair disorders with the goal of developing therapies targetting dysbiosis and immune system dysregulation. 

            Scientific Publications
              Protein kinases: drug targets for immunological disorders.

    Castelo-Soccio L, Kim H, Gadina M, Schwartzberg PL, Laurence A, O'Shea JJ
        

                    Nat Rev Immunol.
        
                    2023 Dec;
        
                    23(12).
        
                    doi: 10.1038/s41577-023-00877-7
                            PMID: 37188939
  Alopecia areata flare patterns in children and young adults while on systemic tofacitinib.

    McKenzie PL, Castelo-Soccio L
        

                    J Am Acad Dermatol.
        
                    2022 Mar;
        
                    86(3).
        
                    doi: 10.1016/j.jaad.2021.02.071
                            PMID: 33667538
  Dupilumab therapy for alopecia areata in pediatric patients with concomitant atopic dermatitis.

    McKenzie PL, Castelo-Soccio L
        

                    J Am Acad Dermatol.
        
                    2021 Jun;
        
                    84(6).
        
                    doi: 10.1016/j.jaad.2021.01.046
                            PMID: 33484763
  Acral Changes in pediatric patients during COVID 19 pandemic: Registry report from the COVID 19 response task force of the society of pediatric dermatology (SPD) and pediatric dermatology research alliance (PeDRA).

    Castelo-Soccio L, Lara-Corrales I, Paller AS, Bean E, Rangu S, Oboite M, Flohr C, Ahmad RC, Calberg V, Gilliam A, Pope E, Reynolds S, Sibbald C, Shin HT, Berger E, Schaffer J, Siegel MP, Cordoro KM
        

                    Pediatr Dermatol.
        
                    2021 Mar;
        
                    38(2).
        
                    doi: 10.1111/pde.14566
                            PMID: 33742457
  Photographing Alopecia: How Many Pixels Are Needed for Clinical Evaluation?

    Bayramova A, Mane T, Hopkins C, Zheng Y, Ogunleye TA, Taylor SC, Castelo-Soccio L, Bernardis E
        

                    J Digit Imaging.
        
                    2020 Dec;
        
                    33(6).
        
                    doi: 10.1007/s10278-020-00389-z
                            PMID: 33009638
  Autosomal recessive hypotrichosis with loose anagen hairs associated with TKFC mutations.

    Onoufriadis A, Cabezas A, Ng JCF, Canales J, Costas MJ, Ribeiro JM, Rodrigues JR, McAleer MA, Castelo-Soccio L, Simpson MA, Fraternali F, Irvine AD, Cameselle JC, McGrath JA
        

                    Br J Dermatol.
        
                    2021 May;
        
                    184(5).
        
                    doi: 10.1111/bjd.19481
                            PMID: 32790068
  Understanding alopecia areata characteristics in children under the age of 4 years.

    Rangu S, Rogers R, Castelo-Soccio L
        

                    Pediatr Dermatol.
        
                    2019 Nov;
        
                    36(6).
        
                    doi: 10.1111/pde.13990
                            PMID: 31468560
  Severity of disease and quality of life in parents of children with alopecia areata, totalis, and universalis: A prospective, cross-sectional study.

    Putterman E, Patel DP, Andrade G, Harfmann KL, Hogeling M, Cheng CE, Goh C, Rogers RS, Castelo-Soccio L
        

                    J Am Acad Dermatol.
        
                    2019 May;
        
                    80(5).
        
                    doi: 10.1016/j.jaad.2018.12.051
                            PMID: 30633941
  Topical 2% tofacitinib for children with alopecia areata, alopecia totalis, and alopecia universalis.

    Putterman E, Castelo-Soccio L
        

                    J Am Acad Dermatol.
        
                    2018 Jun;
        
                    78(6).
        
                    doi: 10.1016/j.jaad.2018.02.031
                            PMID: 29754888
  Pediatric severity of alopecia tool.

    Bernardis E, Nukpezah J, Li P, Christensen T, Castelo-Soccio L
        

                    Pediatr Dermatol.
        
                    2018 Jan;
        
                    35(1).
        
                    doi: 10.1111/pde.13327
                            PMID: 29105836 
          Education
              
            **Cornell University**M.D. (2005)**Cornell University**Ph.D. (2004)**Harvard University**B.A. Biological Sciences (1997)             
                        Experience
              
            **Assistant Professor/Attending Physician**University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia (2011-2021)**Pediatric Dermatology Fellowship**Children’s Hospital of Philadelphia (2010-2011)**Post-Doctoral Fellowship**University of Pennsylvania (2009-2010)**Dermatology Residency**University of Pennsylvania (2006-2009)


Last Updated: March 2024


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