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						HOME
		Search Text: Home/< Back ToThe Science/Mitochondrial Biology and Metabolism
  Mitochondrial Biology and Metabolism
    The Laboratory of Mitochondrial Biology and Metabolism, led by Dr. Michael N. Sack, focuses on modifications of proteins that play pivotal roles in metabolism and mitochondrial function to understand how these modifications affect disease risk.
    On This Page
    
          Michael Sack, M.D., Ph.D.
  Michael Sack, M.D., Ph.D.
          Senior Investigator
          Email
      Meet the Team
            Contact us
  Senior Investigator Research Interests
            
  Research Interests
              ***The Role of Caloric-Dependent Regulation in the Control of Metabolic and Mitochondrial Homeostasis:***My laboratory focuses on understanding, at the basic and clinical level, how nutrient-sensing programs control immune cell function. At the basic science level my laboratory focusses on the role of the nutrient-sensing Sirtuin enzymes, and a counter-regulatory protein, BLOC1S1/GCN5L1, which modulate mitochondrial and endosome-lysosome functions. In the clinic, we use different caloric-load strategies and/or the NAD+ precursor, nicotinamide riboside, to explore immunometabolism and immunomodulation, in both healthy individuals and in inflammatory/autoimmune disease states. The longer-term goal is to exploit these pathways to blunt inflammation and auto-immunity in human disease.
  Clinical Trials and Studies
Pilot Study to Explore the Anti-Inflammatory Effects of Time-Restricted Feeding
				Recruiting
											
											Adult, Older Adult
					
											Male
					
																		Not Accepting Healthy Volunteers

				Are you a male with psoriasis or want to help someone with this condition? This study is exploring whether eating only during certain hours of the day (called time-restricted feeding) can change metabolism and reduce inflammation in the blood of people with mild to moderate psoriasis. To participate in this study, you must be a male between the ages of 18 and 80 with active psoriasis, or be a healthy volunteer. This study is located at the NIH Clinical Center in Bethesda, Maryland.Metabolic or genetic diseases that raise the risk for heart disease
				Recruiting
											
											All Ages
					
											All Genders
					
																		Accepting Healthy Volunteers

				Do you or a first-degree relative have a condition that raises the risk of heart disease? This study aims to test the heart and lung function of people who have a genetic or metabolic disease that raises their risk of heart disease. Participants in this study must be between 2 and 100 years old. This study is located in Bethesda, Maryland.Technical Development of Cardiovascular MRI
				Recruiting
											
											Adult, Older Adult
					
											All Genders
					
																		Accepting Healthy Volunteers

				Are you able to have a magnetic resonance imaging (MRI) scan and want to help people with heart failure? This study is developing new methods for imaging the heart and blood vessels using MRI to improve how healthcare providers diagnose people with heart failure. This study takes place in Maryland and Washington, DC.Pilot Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
				Recruiting
											
											Adult, Older Adult
					
											Female
					
																		Accepting Healthy Volunteers

				Are you an adult woman with lupus?
												In this study, researches will try to determine if an investigational medication is effective in treating lupus in adult women. You must be at least 18 years old. The study will also enroll healthy volunteers who have no history of lupus or other autoimmune disease. The study will take place at the National Institutes of Health Clinical Center in Bethesda, Maryland.Causes and Natural History of Dyslipidemias
				Recruiting
											
											All Ages
					
											All Genders
					
																		Not Accepting Healthy Volunteers

				Do you or your child have dyslipidemia? This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol and high blood triglycerides, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. Participants in this study must be at least 2 years old. The study is being conducted in Bethesda, Maryland.
Featured Publications
                Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects
            Authors:Han K, Singh K, Meadows AM, Sharma R, Hassanzadeh S, Wu J, Goss-Holmes H, Huffstutler RD, Tague HL, Mehta NN, Griffin JL, Tian R, Traba J, Sack MN.
                                                                                                                        
            Cell Reports Medicine
      
                2023 Sep 19;4(101157):
        Read Publication
                      Boosting NAD+ blunts toll-like receptor-4 induced type-I interferon in control and systemic lupus erythematosus monocytes.
            Authors:Wu J, Singh K, Lin A, Meadows AM, Wu K, Shing V, Bley M, Huffstutler RD, Schmidt MS, Blanco LP, Tian R, Brenner C, Pirooznia M, Kaplan MJ, Sack MN
                                                                                                                        
            J. Clin. Invest.
      
                2022 Mar 01;132(5):
        Read Publication
                      Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness
            Authors:Han K, Singh K, Rodman M, Hassanzadeh S, Huffstutler RD, Seifuddin F, Dagur P, McCoy PJ, Chen J, Biancotto A, Stagliano K, Teague H, Mehta NN, Pirooznia M, Sack MN.
                                                                                                                        
            Nature Metabolism
      
                2021 Mar 01;3(3):318-326
        Read Publication
                      BLOC1S1/GCN5L1/BORCS1 is a critical mediator for the initiation of autolysosomal tubulation.
            Authors:Wu K, Seylani A, Wu J, Wu X, Bleck CKE, Sack MN.
                                                                                            
            Autophagy.
      
                2021 Feb 25;Online ahead of print:
        Read Publication
                      Prolonged Fasting Suppresses Mitochondrial NLRP3 Inflammasome Assembly and Activation via SIRT3-mediated Activation of Superoxide Dismutase 2
            Authors:3.	Traba J, Geiger S, Kwarteng-Siaw M, Han K, Ra OH, Siegel RM, Gius D, Sack MN.
                                                                                                                        
            J Biol Chem.
      
                2017 Jul 21;292(29):12153-12164
        Read Publication
  Meet the Team

    Michael Sack, M.D., Ph.D.

            Michael Sack, M.D., Ph.D.
                Senior Investigator
                Michael Sack graduated with his M.B.B.Ch. and M.Sc. from the University of Witwatersrand and earned his Ph.D. in 2000 from the University of Cape Town in South Africa. He did his internship at Johannesburg General Hospital and his internal medicine residency at Georgetown University Medical Center. He conducted cardiology research and did a clinical fellowship at Washington University Medical Center from 1994 to 1997. Dr. Sack joined the NHLBI in 2003. Dr. Sack has authored or coauthored more than 100 papers, editorials, reviews, and book chapters. He currently sits on the editorial boards of the Journal of Molecular and Cellular Cardiology, Mitochondrion, Journal of Gerontology, and Drug Discovery Today and is a member of the American Society for Clinical Investigation.
    
          Contact the lab
    10 Center DrBethesda, MD 20814United States
        Phone:
                    301-402-9259
                Fax:
            301-402-0888
  Kim Han
    
            Kim Han
        

    Staff Scientist

        kim.han@nih.gov
            Shahin Hassanzadeh
    
            Shahin Hassanzadeh
        

    Lab Manager

        sh77v@nih.gov
            Jing Wu
    
            Jing  Wu
        

    Staff Scientist

        jing.wu@nih.gov
            Rachael Klein MD
    
            Rachael Klein, M.D.
        

    Staff Clinician

        rachael.klein@nih.gov
            Rahul Sharma, Ph.D.
    
            Rahul Sharma, Ph.D.
        

    Visiting Fellow

        rahul.sharma2@nih.gov
            Anand Gupta, Ph.D.
    
            Anand Gupta, Ph.D.
        

    Visiting Fellow

        anand.gupta@nih.gov
            Sinibaldo Romero Arocha
        

    NIH-Ox-Cam MD, Ph.D. student

        sinibaldo.romeroarocha@nih.gov
            Russell Steans
    
            Russell Steans
        

    Postbaccalaureate Fellow

        russell.steans@nih.gov
            Anna Russo
    
            Anna Russo
        

    Postbaccalaureate Fellow

        annachiara.russo@nih.gov
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  Alumni
        

Iain Scott, Ph.D.
        

    Research Fellow
        Iain Scott, Ph.D. is currently a Associate Professor of Medicine at University of Pittsburgh.
      Lingdi Wang, Ph.D.
        

    Research Fellow
        Lingdi Wang, Ph.D. is currently a Associate Professor at Tianjin Medical University, Tianjin, China.
      Javier Traba, Ph.D.
        

    Research Fellow
        Javier Traba, Ph.D. is currently a Assistant Professor at Autonomous University of Madrid, Madrid, Spain.
      Kaiyuan  Wu, Ph.D.
        

    Research Fellow
        Kaiyuan  Wu, Ph.D. is currently a Staff Scientist at NHLBI, DIR. Back To Top Link
  

        

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