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						HOME
		Search Text: Home/< Back ToThe Science/IPSC Core
  IPSC Core
    The mission of induced Pluripotent Stem Cells (iPSC) Core is to accelerate stem cell research by providing investigators consultation, technical services and training in human pluripotent stem cell technology.
    On This Page
    
          generic avatar
  Jizhong  Zou, Ph.D.
          Core Director
          Email
      Meet the Team
            Contact us
  
  Research

            The mission of induced Pluripotent Stem Cells (iPSC) Core is to accelerate stem cell research by providing investigators consultation, technical services and training in human pluripotent stem cell technology. The major services that iPSC Core currently provides include (1) generation of human iPSCs from fibroblast cells, CD34+ hematopoietic stem/progenitor cells, and peripheral blood mononuclear cells (PBMCs) using non-integration methods; (2) CRISPR/Cas9 mediated human iPSC gene knockout, gene correction, and AAVS1 safe harbor transgene knockin; (3) human iPSC-cardiomyocyte (CM) differentiation. The Core also provides control iPSC lines and validated iPSC culture reagents. In addition to providing services and consultations to NIH researchers, the Core staff collaborate with investigators to work on custom and exploratory projects. Research conducted by the Core seeks to better understand the mechanisms underlying pluripotent stem cell self-renewal and differentiation to optimize culture conditions and operating procedures.
Featured Publications
                Prolyl hydroxylation regulates protein degradation, synthesis, and splicing in human induced pluripotent stem cell-derived cardiomyocytes.
            Authors:Stoehr A, Yang Y, Patel S, Evangelista AM, Aponte A, Wang G, Liu P, Boylston J, Kloner PH, Lin Y, Gucek M, Zhu J, Murphy E
                                                                                                                        
            Cardiovasc Res
      
                2016 Jun 01;110(3):346-58
        Read Publication
                      Treatment Paradigms for Retinal and Macular Diseases Using 3-D Retina Cultures Derived From Human Reporter Pluripotent Stem Cell Lines.
            Authors:Kaewkhaw R, Swaroop M, Homma K, Nakamura J, Brooks M, Kaya KD, Chaitankar V, Michael S, Tawa G, Zou J, Rao M, Zheng W, Cogliati T, Swaroop A
                                                                                                                        
            Invest Ophthalmol Vis Sci
      
                2016 Apr 01;57(5):ORSFl1-ORSFl11
        Read Publication
                      Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes.
            Authors:Francis KR, Ton AN, Xin Y, O'Halloran PE, Wassif CA, Malik N, Williams IM, Cluzeau CV, Trivedi NS, Pavan WJ, Cho W, Westphal H, Porter FD
                                                                                                                        
            Nat Med
      
                2016 Apr 01;22(4):388-96
        Read Publication
                      Transcriptome Dynamics of Developing Photoreceptors in Three-Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene Networks.
            Authors:Kaewkhaw R, Kaya KD, Brooks M, Homma K, Zou J, Chaitankar V, Rao M, Swaroop A
                                                                                                                        
            Stem Cells
      
                2015 Dec 01;33(12):3504-18
        Read Publication
                      Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein.
            Authors:Qin H, Cho M, Haso W, Zhang L, Tasian SK, Oo HZ, Negri GL, Lin Y, Zou J, Mallon BS, Maude S, Teachey DT, Barrett DM, Orentas RJ, Daugaard M, Sorensen PH, Grupp SA, Fry TJ
                                                                                                                        
            Blood
      
                2015 Jul 30;126(5):629-39
        Read Publication
  Meet the Team

    generic avatar

            Jizhong  Zou, Ph.D.
                Core Director
                Jizhong Zou, Ph.D., is the director of the iPSC Core Facility at the NHLBI.
    
          Contact the lab
    10 Center DriveBethesda, MD 20814United States
        Phone:
                    301-827-7510
                Fax:
  generic avatar
    
            Jeanette  Beers
        

    Biologist

        beersj@mail.nih.gov
            generic avatar
    
            Yongshun  Lin
        

    Staff Scientist

        liny6@mail.nih.gov
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            Kaari Linask
        

    Biologist

        kl198q@nih.gov Back To Top Link
  

        

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