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          About NIAMS
          Shubham Goel, Ph.D.





Shubham Goel, Ph.D.


Research Fellow
    Cutaneous Leukocyte Biology Section Photo of Dr. Goel. 
            Contact Information

                                
                                                10 Center Drive
                  
            Building 10, Room 12N256
      
                  
                                   Bethesda MD 20892
                
                                                shubham.goel@nih.gov 
                Summary
          Dr. Shubham Goel is post-doctoral visiting fellow in the Cutaneous Leukocyte Biology Section at the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

Since 2011, Dr. Goel has conducted research in the molecular mechanism of Primary Immunodeficiency Diseases (PIDs) to understand the clinical and basic aspects of the disease pathophysiology while supporting medical health care.
        
                  Research Statement
          
            PIDs patients are affected by microorganism communities either alone or in combination. For example, a CARD9 deficiency mainly affects the fungal infection of one phylum (Ascomycota), while a STAT3 deficiency might lead to a Staph aureus and CMC infection. On the other hand, DOCK8 deficient patients present with viral infections only. Thus, a unique infection profile is evident for each immune gene defect suggesting their distinct role in maintaining skin homeostasis. Using a sample of patients and a mice model, and with the help of high-throughput techniques like single-cell RNA-seq, it will be possible to relate the mechanism of the susceptibility of a single type of infection to one type of gene defect.In the future, Dr. Goel plans to develop a new diagnostic assay and delineate the molecular mechanism of unknown and new PIDs with respect to skin biology and infections. 

            Scientific Publications
              Expression of CD40 Ligand on T Cells and Soluble CD40 Ligand in Children With Kawasaki Disease: A Single-Center Preliminary Study From North India.

    Jindal AK, Rawat A, Goel S, Shandilya J, Saikia B, Minz RW, Singh S
        

                    J Clin Rheumatol.
        
                    2021 Aug 1;
        
                    27(5).
        
                    doi: 10.1097/RHU.0000000000001283
                            PMID: 31985724
  Myriad Faces of Chronic Granulomatous Disease: All in an Indian Family with Novel CYBB Defect.

    Vignesh P, Sharma M, Pilania RK, Shandilya JK, Kaur A, Goel S, Kaur A, Suri D, Rawat A, Dalal A, Sarma AS, Singh S
        

                    J Clin Immunol.
        
                    2019 Aug;
        
                    39(6).
        
                    doi: 10.1007/s10875-019-00661-0
                            PMID: 31338742
  Clinical and molecular features of X-linked hyper IgM syndrome - An experience from North India.

    Rawat A, Mathew B, Pandiarajan V, Jindal A, Sharma M, Suri D, Gupta A, Goel S, Karim A, Saikia B, Minz RW, Imai K, Nonoyama S, Ohara O, Giliani SC, Notarangelo LD, Chan KW, Lau YL, Singh S
        

                    Clin Immunol.
        
                    2018 Oct;
        
                    195().
        
                    doi: 10.1016/j.clim.2018.07.013
                            PMID: 30053428
  STAT3-Mediated Transcriptional Regulation of Osteopontin in STAT3 Loss-of-Function Related Hyper IgE Syndrome.

    Goel S, Sahu S, Minz RW, Singh S, Suri D, Oh YM, Rawat A, Sehgal S, Saikia B
        

                    Front Immunol.
        
                    2018;
        
                    9().
        
                    doi: 10.3389/fimmu.2018.01080
                            PMID: 29868029
  Large BTK gene mutation in a child with X-linked agammaglobulinemia and polyarthritis.

    Sharma D, Gupta A, Goel S, Sharma M, Rawat A, Singh S
        

                    Clin Immunol.
        
                    2017 Oct;
        
                    183().
        
                    doi: 10.1016/j.clim.2017.08.005
                            PMID: 28807838
  Severe Aspergillus Pneumonia and Pulmonary Artery Hypertension in a Child with Autosomal Recessive Chronic Granulomatous Disease and Selective IgA Deficiency.

    Jindal AK, Rawat A, Suri D, Sharma M, Shandilya JK, Goel S, Sodhi KS, Singh S
        

                    J Clin Immunol.
        
                    2017 May;
        
                    37(4).
        
                    doi: 10.1007/s10875-017-0386-6
                            PMID: 28342009
  Novel Mutation in SH2 Domain of STAT3 (p.M660T) in Hyper-IgE Syndrome with Sterno-Clavicular and Paravertebral Abscesses.

    Saikia B, Goel S, Suri D, Minz RW, Rawat A, Singh S
        

                    Indian J Pediatr.
        
                    2017 Jun;
        
                    84(6).
        
                    doi: 10.1007/s12098-017-2336-y
                            PMID: 28315006
  TH17 Cells in STAT3 Related Hyper-IgE Syndrome.

    Sharma S, Saikia B, Goel S, Rawat A, Minz RW, Suri D, Chhabra S, Singh S
        

                    Indian J Pediatr.
        
                    2016 Oct;
        
                    83(10).
        
                    doi: 10.1007/s12098-016-2150-y
                            PMID: 27226025
  Hyper-IgE syndrome with a novel STAT3 mutation-a single center study from India.

    Saikia B, Suri D, Goel S, Rawat A, Minz RW, Gupta A, Sharma S, Ohara O, Imai K, Nonoyama S, Sehgal S, Singh S
        

                    Asian Pac J Allergy Immunol.
        
                    2014 Dec;
        
                    32(4).
        
                    doi: 10.12932/AP0456.32.4.2014
                            PMID: 25543043
  Expression of γH2AX may help in defining a genetically more stable subtype of infiltrating ductal carcinoma of breast.

    Bhatia A, Dey P, Goel S, Singh G
        

                    Indian J Med Res.
        
                    2013 Apr;
        
                    137(4).
  Spontaneously occurring micronuclei in infiltrating ductal carcinoma of breast: a potential biomarker for aggressive phenotype detection?

    Goel S, Bhatia A, Dey P
        

                    Diagn Cytopathol.
        
                    2013 Apr;
        
                    41(4).
        
                    doi: 10.1002/dc.21836
                            PMID: 21987354 
          Education
              
            **Department of Immunopathology, PGIMER, Chandigarh, India**Ph.D. (Immunology)**Department of Experimental Medicine and Biotechnology, PGIMER, Chandigarh, India**M.Sc. (Medical Biotechnology)**Department of Microbiology, Swami Shraddhanand College, University of Delhi, India**BSc (H) Microbiology             
                        Experience
              
            **Department of Laboratory Medicine, National Institutes of Health**Post-Doctoral Visiting Fellow (2017-Present)**Department of Pediatrics, Advance Pediatrics Center, PGIMER, Chandigarh, India**Research Associate (2016-2017)**Department of Immunopathology, PGIMER, Chandigarh, India**ICMR-Senior Research Fellow (2015-2016)


Last Updated: March 2024


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