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		Search Text: Clinical Trials
					
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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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      How Clinical Trials Work
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      Who Can Participate
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      Benefits, Risks & Safety Measures
Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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CLEARAnemiaAplastic AnemiaArrhythmiasAtrial FibrillationBleeding DisordersCardiomyopathyCoronary Artery Bypass GraftingCoronary Heart DiseaseHeart-Healthy LivingHeart FailureHeart SurgeryHeart Valve DiseasesHemolytic AnemiaHigh Blood PressurePeripheral Artery DiseasePneumoniaRespiratory FailureSickle Cell DiseaseStroke

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Showing 1 - 10 out of 17 results
      
      Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
      Recruiting
                          Multiple Locations
        Are you 75 years old or older and interested in participating in a clinical trial where researchers are studying whether statins, which are often used to treat high cholesterol, can help improve heart and brain health. To participate, you cannot have cardiovascular disease or dementia. The study is taking place at locations in Alabama, Arizona, Arkansas, California, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Nebraska, Nevada, New York, North Carolina, Ohio, Pennsylvania, Rhode Island, South Carolina, Tennessee, Texas, Utah, Virginia, West Virginia, Wisconsin, and Puerto Rico.
      Coronary Heart Disease
                          Older Adult
                                      Accepting Healthy Volunteers
    A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)
      Recruiting
                          Multiple Locations
        This trial will compare time from randomization to failure of treatment or death from any cause of IST versus URD BMT when used as initial therapy to treat Severe Aplastic Anemia.
      Anemia
                          Child, Adult
    Trauma Resuscitation With Low-Titer Group O Whole Blood or Products
      Recruiting
                          Multiple Locations
        The goal of this clinical trial is to compare different types of blood transfusions for critically injured patients who require large-volume blood transfusions. Participants must be at least 15 years old and need a massive blood transfusion. The study is taking place in locations in Alabama, California, Louisiana, Maryland, Missouri, North Carolina, Ohio, Oregon, Pennsylvania, Texas, Washington, and Wisconsin.
      Bleeding Disorders
                          All Ages
    CTSN Embolic Protection Trial
      Recruiting
                          Multiple Locations
        Do you have mitral valve disease? This clinical trial is testing different types of images taken of the heart to learn more about mitral valve disease and the best ways to treat it. You must be 60 years old to participate. The study is enrolling patients in locations in Arkansas, California, Georgia, Indiana, Louisiana, Maine, Maryland, Massachusetts, Michigan, Missouri, New York, North Carolina, Ohio, Pennsylvania, and Quebec City, Canada.
      Coronary Heart Disease
              Heart Valve Diseases
                          Adult, Older Adult
    Bone Marrow Transplantation vs. Standard of Care in Patients With Severe Sickle Cell Disease
      Recruiting
                          Multiple Locations
        Are you 15 to 40 years old and have severe sickle cell disease?
                    This study is comparing long-term outcomes for patients who receive blood and bone marrow transplants and those who receive standard treatment with medicines. Participants also have an option of contributing blood samples to be stored for future research. Participants must be 15 to 40 years old and have severe sickle cell disease. This study is located in Madison, Wisconsin.
      Sickle Cell Disease
                          Child, Adult
    Sickle Cell Clinical Research and Intervention Program
      Recruiting
                          Multiple Locations
        Do you or your child have sickle cell disease and also have an interest in contributing to long-term data collection?
                    This study is monitoring patients and collecting biological samples from patients who have sickle cell disease to better understand long-term outcomes. Participants can be any age and must have sickle cell disease. This study is located in six sites in Illinois, Louisiana, North Carolina, and Tennessee.
      Sickle Cell Disease
                          All Ages
    Transplants With Unlicensed Preserved Cord Blood
      Recruiting
                          Multiple Locations
        Are you scheduled for a stem cell transplant with cord blood?
                    This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.
      Anemia
              Hemolytic Anemia
              Aplastic Anemia
                          All Ages
    Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control (IMPACTS)
      Recruiting
                          Louisiana
              Mississippi
        Do you have high blood pressure, and do you receive care at a community-based clinic in the South?
                    This study will explore an intensive high blood pressure management approach at participating community-based clinics. The approach aims to lower participants’ systolic blood pressure to 120 mm Hg. To participate in this study, you must be at least 40 years old, understand English, and not be pregnant. The study is located in Louisiana, Alabama, and Mississippi.
      Heart-Healthy Living
              High Blood Pressure
                          Adult, Older Adult
    Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG (PACES)
      Recruiting
                          Multiple Locations
        Did you develop atrial fibrillation after coronary artery bypass graft (CABG) surgery?
                    Did you develop atrial fibrillation after a coronary artery bypass grafting (CABG) surgery? This study is looking at how well oral anticoagulation medicines work to prevent complications, such as blood clots and heart attack, for patients who experience post-operative atrial fibrillation (POAF). This study is in multiple locations around the country.
      Arrhythmias
              Atrial Fibrillation
              Coronary Artery Bypass Grafting
              Stroke
              Heart Surgery
                          Adult, Older Adult
    ARrest RESpiraTory Failure From PNEUMONIA
      Recruiting
                          Multiple Locations
        Do you or a loved one have pneumonia? 
                    This study will test whether combining two medicines to reduce inflammation of the airway and to keep it open may help prevent respiratory failure in people who have pneumonia. To participate in this study, you must be at least 18 years old and have severe pneumonia with low blood oxygen levels.
      Pneumonia
              Respiratory Failure
                          Adult, Older Adult
  
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