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          About NIAMS
          Zuoming Deng, Ph.D.





Zuoming Deng, Ph.D.


Staff Scientist
    Biodata Mining and Discovery Section Profile Image 
            Contact Information

                                                  301-496-3194
                
                                                9000 Rockville Pike
                  
                  
            Building 50, Room 1140
      
                                   Bethesda MD 20892
                
                                                zuoming.deng@nih.gov 
                Summary
          Dr. Deng received his Ph.D. in Human Molecular Genetics from the University of Texas M. D. Anderson Cancer Center and Graduate School of Biomedical Sciences. He also has an M.S. in Computer Science from Johns Hopkins University. His research career spans academia, industry and government with extensive experience in human genetics, genomics, and bioinformatics.
        
                  Research Statement
          
            Mutation analysis and functional genomics through Next Generation Sequencing and computational tools development. 

            Scientific Publications
              Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway.

    Kang H, Jha S, Ivovic A, Fratzl-Zelman N, Deng Z, Mitra A, Cabral WA, Hanson EP, Lange E, Cowen EW, Katz J, Roschger P, Klaushofer K, Dale RK, Siegel RM, Bhattacharyya T, Marini JC
        

                    J Exp Med.
        
                    2020 May 4;
        
                    217(5).
        
                    doi: 10.1084/jem.20191499
                            PMID: 32232430
  Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.

    de Jesus AA, Hou Y, Brooks S, Malle L, Biancotto A, Huang Y, Calvo KR, Marrero B, Moir S, Oler AJ, Deng Z, Montealegre Sanchez GA, Ahmed A, Allenspach E, Arabshahi B, Behrens E, Benseler S, Bezrodnik L, Bout-Tabaku S, Brescia AC, Brown D, Burnham JM, Caldirola MS, Carrasco R, Chan AY, Cimaz R, Dancey P, Dare J, DeGuzman M, Dimitriades V, Ferguson I, Ferguson P, Finn L, Gattorno M, Grom AA, Hanson EP, Hashkes PJ, Hedrich CM, Herzog R, Horneff G, Jerath R, Kessler E, Kim H, Kingsbury DJ, Laxer RM, Lee PY, Lee-Kirsch MA, Lewandowski L, Li S, Lilleby V, Mammadova V, Moorthy LN, Nasrullayeva G, O'Neil KM, Onel K, Ozen S, Pan N, Pillet P, Piotto DG, Punaro MG, Reiff A, Reinhardt A, Rider LG, Rivas-Chacon R, Ronis T, Rösen-Wolff A, Roth J, Ruth NM, Rygg M, Schmeling H, Schulert G, Scott C, Seminario G, Shulman A, Sivaraman V, Son MB, Stepanovskiy Y, Stringer E, Taber S, Terreri MT, Tifft C, Torgerson T, Tosi L, Van Royen-Kerkhof A, Wampler Muskardin T, Canna SW, Goldbach-Mansky R
        

                    J Clin Invest.
        
                    2020 Apr 1;
        
                    130(4).
        
                    doi: 10.1172/JCI129301
                            PMID: 31874111
  Somatic activating mutations in MAP2K1 cause melorheostosis.

    Kang H, Jha S, Deng Z, Fratzl-Zelman N, Cabral WA, Ivovic A, Meylan F, Hanson EP, Lange E, Katz J, Roschger P, Klaushofer K, Cowen EW, Siegel RM, Marini JC, Bhattacharyya T
        

                    Nat Commun.
        
                    2018 Apr 11;
        
                    9(1).
        
                    doi: 10.1038/s41467-018-03720-z
                            PMID: 29643386
  Germline gain-of-function myeloid differentiation primary response gene-88 (MYD88) mutation in a child with severe arthritis.

    Sikora KA, Bennett JR, Vyncke L, Deng Z, Tsai WL, Pauwels E, Layh-Schmitt G, Brundidge A, Navid F, Zaal KJM, Hanson E, Gadina M, Staudt LM, Griffin TA, Tavernier J, Peelman F, Colbert RA
        

                    J Allergy Clin Immunol.
        
                    2018 May;
        
                    141(5).
        
                    doi: 10.1016/j.jaci.2018.01.027
                            PMID: 29427642
  An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.

    Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O'Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R
        

                    Nat Genet.
        
                    2014 Oct;
        
                    46(10).
        
                    doi: 10.1038/ng.3089
                            PMID: 25217959
  Activated STING in a vascular and pulmonary syndrome.

    Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Sanchez GAM, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CR, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St Hilaire C, Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R
        

                    N Engl J Med.
        
                    2014 Aug 7;
        
                    371(6).
        
                    doi: 10.1056/NEJMoa1312625
                            PMID: 25029335 
          Education
              
            Ph.D. in Human Molecular Genetics, University of Texas M. D. Anderson Cancer Center and Graduate School of Biomedical Sciences.
	M.S. in Computer Science, Johns Hopkins University
	B.S. in Biochemistry, Sichuan University             
                        Experience
              
            Staff Scientist, BMDS, OST, NIAMS, NIH
	Senior Bioinformatics Application Scientist, Complete Genomics
	Senior Scientist, CGF, NCI, NIH
	Computational Biologist, ARS, USDA
	Bioinformatics Scientist, Northrop Grumman
	Staff Scientist, Celera Genomics
	Postdoctoral Fellow, NHGRI/NIAMS, NIH


Last Updated: October 2022


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