An official website of the United States government
          Here’s how you know
        Here’s how you know**Official websites use .gov**A
              **.gov** website belongs to an official government
              organization in the United States.
        **Secure .gov websites use HTTPS**A
              **lock** (
              Locked padlock icon) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
 Top Utility Nav
        
        
        Asian-Language Resources
        
        Portal en español


Site search Mega Menu
  

        

        Home
                  Health Topics
                                      
    
  Health Topics

    Arthritis and Rheumatic Diseases
          
    Muscle and Bone Diseases
          
    Skin Diseases
          
    All Diseases and Conditions
          
    Publication Catalog
                  Grants & Funding
                                      
    
  Grants & Funding

    Current Funding Opportunities
          
    Supported Scientific Programs
          
    NIAMS-Supported Programs
          
    Applying for a Grant
          
    NIH Policies and Guidance
          
    Peer Review and Grants Administration Resources
          
    Types of Funding Mechanisms (Activity Codes)
                  Labs @ NIAMS
                                      
    
  Labs @ NIAMS

    NIAMS Labs and Core Facilities
          
    Research Faculty
          
    Research Areas
          
    NIAMS Scientific Advances
          
    Training and Career Development
                  Clinical Trials
                                      
    
  Clinical Trials
      
            For Principal Investigators

    Clinical Trial Policies, Guidelines, and Templates
          
    Conducting Clinical Trials
          
    Register with ClinicalTrials.gov

For Patients

What is a Clinical Trial?
	Clinical Trials at NIAMS
	Clinical Trials in the Spotlight
                  News & Events
                                      
    
  Newsroom

    All NIAMS News
          
    NIAMS Newsletters
          
    Meetings & Events
                  About NIAMS
                                      
    
  About NIAMS

    Director's Page
          
    NIAMS Organization
          
    Strategic Plan Fiscal Years 2020-2024
          
    Staff Directory
          
    NIAMS Budget
          
    Partnerships
          
    Contact NIAMS
                  Community Outreach
                                      
    
  Community Outreach

    Bone Health
          
    Joint Health
          
    Muscle, Tendon, and Ligament Health
          
    Skin Health
          
    Health Information For Kids And Young Adults
          
    Health Information For Older Adults/Seniors
          
    Printable Materials for Community Events
          
    Resources in Other Languages
          
    Annual Health Observances
          
    Social Media Resources Breadcrumb
    Home
          About NIAMS
          Hong-Wei Sun, Ph.D.





Hong-Wei Sun, Ph.D.


Staff Scientist
    Chief, Biodata Mining and Discovery Section
    Office of Science and Technology Image
              Headshot of a man in office attire. 
            Contact Information

                                                  301-496-0016
                
                                                9000 Rockville Pike
                  
                  
            Building 50, Room 1139
      
                                   Bethesda MD 20892
                
                                                sunh1@mail.nih.gov 
                Summary
          Dr. Sun received his Ph.D. from The University of Iowa and conducted his post-doc research at Yale University where he solved the X-ray crystal structure of a cytokine (MIF). He is a founding member of four Bioinformatics groups, a co-author of a Medical Bioinformatics textbook, a co-inventor of nine issued patents, and a co-author of two published Java programs for biomedical research (JOINSOLVER & PAPST).
        
                  Research Statement
          
            As the institute’s bioinformatics core facility, Biodata Mining and Discovery Section focuses on applying computational approaches of Data Sciences to biomedical research. We also develop and implement computational algorithms and methods mostly used in analyzing NGS data such as those from RNA-Seq, ChIP-Seq, ATAC-Seq, and single cell RNA-Seq. 

            Scientific Publications
              MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23.

    Mikami Y, Philips RL, Sciumè G, Petermann F, Meylan F, Nagashima H, Yao C, Davis FP, Brooks SR, Sun HW, Takahashi H, Poholek AC, Shih HY, Afzali B, Muljo SA, Hafner M, Kanno Y, O'Shea JJ
        

                    Immunity.
        
                    2021 Mar 9;
        
                    54(3).
        
                    doi: 10.1016/j.immuni.2021.02.015
                            PMID: 33657395
  BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8(+) T cells.

    Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T
        

                    Nat Immunol.
        
                    2021 Mar;
        
                    22(3).
        
                    doi: 10.1038/s41590-021-00868-7
                            PMID: 33574619
  FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age.

    García-Prat L, Perdiguero E, Alonso-Martín S, Dell'Orso S, Ravichandran S, Brooks SR, Juan AH, Campanario S, Jiang K, Hong X, Ortet L, Ruiz-Bonilla V, Flández M, Moiseeva V, Rebollo E, Jardí M, Sun HW, Musarò A, Sandri M, Del Sol A, Sartorelli V, Muñoz-Cánoves P
        

                    Nat Cell Biol.
        
                    2020 Nov;
        
                    22(11).
        
                    doi: 10.1038/s41556-020-00593-7
                            PMID: 33106654
  Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism.

    Gupta S, Nakabo S, Blanco LP, O'Neil LJ, Wigerblad G, Goel RR, Mistry P, Jiang K, Carmona-Rivera C, Chan DW, Wang X, Pedersen HL, Gadkari M, Howe KN, Naz F, Dell'Orso S, Hasni SA, Dempsey C, Buscetta A, Frischmeyer-Guerrerio PA, Kruszka P, Muenke M, Franco LM, Sun HW, Kaplan MJ
        

                    Proc Natl Acad Sci U S A.
        
                    2020 Jul 14;
        
                    117(28).
        
                    doi: 10.1073/pnas.2003603117
                            PMID: 32601182
  Single-cell RNA-seq reveals TOX as a key regulator of CD8(+) T cell persistence in chronic infection.

    Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T
        

                    Nat Immunol.
        
                    2019 Jul;
        
                    20(7).
        
                    doi: 10.1038/s41590-019-0403-4
                            PMID: 31209400
  The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1.

    Petermann F, Pękowska A, Johnson CA, Jankovic D, Shih HY, Jiang K, Hudson WH, Brooks SR, Sun HW, Villarino AV, Yao C, Singleton K, Akondy RS, Kanno Y, Sher A, Casellas R, Ahmed R, O'Shea JJ
        

                    Mol Cell.
        
                    2019 Sep 19;
        
                    75(6).
        
                    doi: 10.1016/j.molcel.2019.06.025
                            PMID: 31377117
  Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus.

    Mistry P, Nakabo S, O'Neil L, Goel RR, Jiang K, Carmona-Rivera C, Gupta S, Chan DW, Carlucci PM, Wang X, Naz F, Manna Z, Dey A, Mehta NN, Hasni S, Dell'Orso S, Gutierrez-Cruz G, Sun HW, Kaplan MJ
        

                    Proc Natl Acad Sci U S A.
        
                    2019 Dec 10;
        
                    116(50).
        
                    doi: 10.1073/pnas.1908576116
                            PMID: 31754025
  Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology.

    Schwartz DM, Farley TK, Richoz N, Yao C, Shih HY, Petermann F, Zhang Y, Sun HW, Hayes E, Mikami Y, Jiang K, Davis FP, Kanno Y, Milner JD, Siegel R, Laurence A, Meylan F, O'Shea JJ
        

                    Immunity.
        
                    2019 Jan 15;
        
                    50(1).
        
                    doi: 10.1016/j.immuni.2018.12.014
                            PMID: 30650370
  Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells.

    Sarshad AA, Juan AH, Muler AIC, Anastasakis DG, Wang X, Genzor P, Feng X, Tsai PF, Sun HW, Haase AD, Sartorelli V, Hafner M
        

                    Mol Cell.
        
                    2018 Sep 20;
        
                    71(6).
        
                    doi: 10.1016/j.molcel.2018.07.020
                            PMID: 30146314
  A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans.

    Tsai PF, Dell'Orso S, Rodriguez J, Vivanco KO, Ko KD, Jiang K, Juan AH, Sarshad AA, Vian L, Tran M, Wangsa D, Wang AH, Perovanovic J, Anastasakis D, Ralston E, Ried T, Sun HW, Hafner M, Larson DR, Sartorelli V
        

                    Mol Cell.
        
                    2018 Jul 5;
        
                    71(1).
        
                    doi: 10.1016/j.molcel.2018.06.008
                            PMID: 29979962
  The effects of shared information on semantic calculations in the gene ontology.

    Bible PW, Sun HW, Morasso MI, Loganantharaj R, Wei L
        

                    Comput Struct Biotechnol J.
        
                    2017;
        
                    15().
        
                    doi: 10.1016/j.csbj.2017.01.009
                            PMID: 28217262
  Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality.

    Shih HY, Sciumè G, Mikami Y, Guo L, Sun HW, Brooks SR, Urban JF Jr, Davis FP, Kanno Y, O'Shea JJ
        

                    Cell.
        
                    2016 May 19;
        
                    165(5).
        
                    doi: 10.1016/j.cell.2016.04.029
                            PMID: 27156451
  PAPST, a User Friendly and Powerful Java Platform for ChIP-Seq Peak Co-Localization Analysis and Beyond.

    Bible PW, Kanno Y, Wei L, Brooks SR, O'Shea JJ, Morasso MI, Loganantharaj R, Sun HW
        

                    PLoS One.
        
                    2015;
        
                    10(5).
        
                    doi: 10.1371/journal.pone.0127285
                            PMID: 25970601 
          Education
              
            **University of Iowa, Iowa City, Iowa**
Ph.D.

**University of Toronto, Toronto, Canada**
M.S.             
                        Experience
              
            **Chief**
Biodata Mining and Discovery Section, OST, NIAMS, NIH**Senior Staff Scientist, Bioinformatics**
Gene Logic Inc.

**Staff Scientist, Bioinformatics**
Bayer Corporation

**Post-doc, Structural Biology**
Yale University


Last Updated: June 2023


Back to Top
 About NIAMS
                    Clinical Trials
                    Grants & Funding
                    Health Topics
                    Labs @ NIAMS
              News Room
                    NIAMS Multimedia Library
                    Disclaimer
                    FOIA
                    Contact us
              Privacy Statement
                    Accessibility
                    HHS Vulnerability Disclosure
                    Social Media Moderation Policy
                    NIAMS Archives
        Subscribe to Our E-Newsletters
            Click the button to see different options to sign up for newsletters.
            Click Here to Subscribe
          Follow us on
  
  About NIH
                  Accessibility Support
            FOIA requests
                  No FEAR Act data
            Office of the Inspector General
                  Performance reports
            Privacy Policy