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          About NIAMS
          Peter Grayson, M.D., M.Sc.





Peter Grayson, M.D., M.Sc.


Investigator
    Chief, Vasculitis Translational Research Program Image
              Photo of Peter Grayson 
            Contact Information

                                                  301-827-9187
                
                                                9000 Rockville Pike
                  
            10 Center Drive
      
                  
            Building 10, Room 12N248
      
                                   Bethesda MD 20892
                
                                                peter.grayson@nih.gov 
                                          Media Resources
                                  
            High Resolution Image 
                Summary
          Dr. Grayson is board-certified in Internal Medicine and Rheumatology. He completed his undergraduate degree from Brown University in 1999, his medical degree from the Medical University of South Carolina in 2004, and a Masters in Science from Boston University in 2008. He served as a Chief Resident in Internal Medicine at Boston Medical Center and completed an additional two-year vasculitis fellowship within the Vasculitis Clinical Research Consortium.Dr. Grayson’s research focuses on clinical and translational research across many forms of systemic vasculitis. Specifically, his work has focused on biomarker discovery/development, the use of advanced molecular imaging, molecular classification of disease, clinical trials, and genetics/genomics of vasculitis. His group has clinically defined the use of advanced molecular imaging as a surrogate marker of vascular inflammation in large-vessel vasculitis.  His group has conducted some of the only translational work related to relapsing polychondritis, including the identification of somatic mutations in UBA1 as a driver of disease in a subset of these patients.  Translational work from the group has also defined novel pathways of neutrophil-mediated inflammation in monogenic vasculitis and drug-induced vasculitis and has identified novel biomarkers of disease activity in many forms of vasculitis that suggest novel therapeutic targets.Dr. Grayson has a strong commitment to mentoring young investigators in rare disease research. He serves as the Associate Program Director for the NIAMS Rheumatology Fellowship Program and he is the recipient of numerous teaching awards. He is actively involved in leadership roles within the American College of Rheumatology and was a recipient of the American College of Rheumatology’s Distinguished Fellow Award in 2011. He has served on the editorial board for *Arthritis & Rheumatology*and the *Journal of Rheumatology*. He currently serves on the Board of Directors for the Vasculitis Foundation and is a Steering Committee member on the Vasculitis Clinical Research Consortium. 

            Scientific Publications
              2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis.

    Suppiah R, Robson JC, Grayson PC, Ponte C, Craven A, Khalid S, Judge A, Hutchings A, Merkel PA, Luqmani RA, Watts RA, DCVAS Study Group
        

                    Arthritis Rheumatol.
        
                    2022 Mar;
        
                    74(3).
        
                    doi: 10.1002/art.41983
                            PMID: 35106973
  2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis With Polyangiitis.

    Grayson PC, Ponte C, Suppiah R, Robson JC, Craven A, Judge A, Khalid S, Hutchings A, Luqmani RA, Watts RA, Merkel PA, DCVAS Study Group
        

                    Arthritis Rheumatol.
        
                    2022 Mar;
        
                    74(3).
        
                    doi: 10.1002/art.41982
                            PMID: 35106968
  2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Granulomatosis With Polyangiitis.

    Robson JC, Grayson PC, Ponte C, Suppiah R, Craven A, Judge A, Khalid S, Hutchings A, Watts RA, Merkel PA, Luqmani RA, DCVAS Study Group
        

                    Arthritis Rheumatol.
        
                    2022 Mar;
        
                    74(3).
        
                    doi: 10.1002/art.41986
                            PMID: 35106964
  Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

    Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, Pei W, Balanda N, Ross DL, Ospina Cardona D, Wu Z, Patel B, Manthiram K, Groarke EM, Gutierrez-Rodrigues F, Hoffmann P, Rosenzweig S, Nakabo S, Dillon LW, Hourigan CS, Tsai WL, Gupta S, Carmona-Rivera C, Asmar AJ, Xu L, Oda H, Goodspeed W, Barron KS, Nehrebecky M, Jones A, Laird RS, Deuitch N, Rowczenio D, Rominger E, Wells KV, Lee CR, Wang W, Trick M, Mullikin J, Wigerblad G, Brooks S, Dell'Orso S, Deng Z, Chae JJ, Dulau-Florea A, Malicdan MCV, Novacic D, Colbert RA, Kaplan MJ, Gadina M, Savic S, Lachmann HJ, Abu-Asab M, Solomon BD, Retterer K, Gahl WA, Burgess SM, Aksentijevich I, Young NS, Calvo KR, Werner A, Kastner DL, Grayson PC
        

                    N Engl J Med.
        
                    2020 Dec 31;
        
                    383(27).
        
                    doi: 10.1056/NEJMoa2026834
                            PMID: 33108101
  Defining Clinical Subgroups in Relapsing Polychondritis: A Prospective Observational Cohort Study.

    Ferrada M, Rimland CA, Quinn K, Sikora K, Kim J, Allen C, Sirajuddin A, Goodspeed W, Chen M, Grayson PC
        

                    Arthritis Rheumatol.
        
                    2020 Aug;
        
                    72(8).
        
                    doi: 10.1002/art.41270
                            PMID: 32249511
  Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2.

    Carmona-Rivera C, Khaznadar SS, Shwin KW, Irizarry-Caro JA, O'Neil LJ, Liu Y, Jacobson KA, Ombrello AK, Stone DL, Tsai WL, Kastner DL, Aksentijevich I, Kaplan MJ, Grayson PC
        

                    Blood.
        
                    2019 Jul 25;
        
                    134(4).
        
                    doi: 10.1182/blood.2018892752
                            PMID: 31015188
  (18) F-Fluorodeoxyglucose-Positron Emission Tomography As an Imaging Biomarker in a Prospective, Longitudinal Cohort of Patients With Large Vessel Vasculitis.

    Grayson PC, Alehashemi S, Bagheri AA, Civelek AC, Cupps TR, Kaplan MJ, Malayeri AA, Merkel PA, Novakovich E, Bluemke DA, Ahlman MA
        

                    Arthritis Rheumatol.
        
                    2018 Mar;
        
                    70(3).
        
                    doi: 10.1002/art.40379
                            PMID: 29145713
  A role for muscarinic receptors in neutrophil extracellular trap formation and levamisole-induced autoimmunity.

    Carmona-Rivera C, Purmalek MM, Moore E, Waldman M, Walter PJ, Garraffo HM, Phillips KA, Preston KL, Graf J, Kaplan MJ, Grayson PC
        

                    JCI Insight.
        
                    2017 Feb 9;
        
                    2(3).
        
                    doi: 10.1172/jci.insight.89780
                            PMID: 28194438
  Neutrophil-Related Gene Expression and Low-Density Granulocytes Associated With Disease Activity and Response to Treatment in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

    Grayson PC, Carmona-Rivera C, Xu L, Lim N, Gao Z, Asare AL, Specks U, Stone JH, Seo P, Spiera RF, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Tchao NK, Ytterberg SR, Phippard DJ, Merkel PA, Kaplan MJ, Monach PA, Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group
        

                    Arthritis Rheumatol.
        
                    2015 Jul;
        
                    67(7).
        
                    doi: 10.1002/art.39153
                            PMID: 25891759


Last Updated: January 2024


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