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          About NIAMS
          Davide Randazzo, Ph.D.





Davide Randazzo, Ph.D.


Staff Scientist
    Chief, Light Imaging Section
    Office of Science and Technology Image
              Photo of Davide Randazzo 
            Contact Information

                                                  301-402-5806
                
                                                9000 Rockville Pike
                  
            50 South Drive
      
                  
            Building 50, Room 1531
      
                                   Bethesda MD 20892
                
                                                davide.randazzo@nih.gov 
                Summary
          Davide Randazzo, Ph.D., received his B.S. in biological sciences (summa cum laude) in 2005 at the University of Palermo (Italy) discussing a thesis focused on the regulation of muscle-specific transcription factors during early and late muscle cell differentiation. This work continued as Dr. Randazzo earned his doctoral degree as part of a partnership with the University of Palermo and the National Council of Researches, Italy, from 2007 to 2009. In 2010, he moved to the University of Siena for a postdoctoral position where he characterized a mouse model knockout for the muscle protein Obscurin. In 2014, he moved to U.S. for a position as a visiting fellow at the NIAMS.
        
                  Research Statement
          
            Dr. Randazzo's research focuses on: skeletal muscle physiology; structural organization of the sarcomere in striated muscles; organization and function of the microtubule cytoskeleton in healthy and diseased skeletal muscle fibers; and Duchenne muscular dystrophy and related murine models. 

            Scientific Publications
              The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

    Perconti G, Ferro A, Amato F, Rubino P, Randazzo D, Wolff T, Feo S, Giallongo A
        

                    Biochim Biophys Acta.
        
                    2007 Dec;
        
                    1773(12).
  Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity.

    Randazzo D, Giacomello E, Lorenzini S, Rossi D, Pierantozzi E, Blaauw B, Reggiani C, Lange S, Peter AK, Chen J, Sorrentino V
        

                    J Cell Biol.
        
                    2013 Feb 18;
        
                    200(4).
        
                    doi: 10.1083/jcb.201205118
                            PMID: 23420875
  The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE).

    Giurisato E, Gamberucci A, Ulivieri C, Marruganti S, Rossi E, Giacomello E, Randazzo D, Sorrentino V
        

                    Mol Biol Cell.
        
                    2014 Jun;
        
                    25(11).
        
                    doi: 10.1091/mbc.E13-05-0292
                            PMID: 24672054
  Organization of junctional sarcoplasmic reticulum proteins in skeletal muscle fibers.

    Barone V, Randazzo D, Del Re V, Sorrentino V, Rossi D
        

                    J Muscle Res Cell Motil.
        
                    2015 Dec;
        
                    36(6).
        
                    doi: 10.1007/s10974-015-9421-5
                            PMID: 26374336
  Human pericytes isolated from adipose tissue have better differentiation abilities than their mesenchymal stem cell counterparts.

    Pierantozzi E, Badin M, Vezzani B, Curina C, Randazzo D, Petraglia F, Rossi D, Sorrentino V
        

                    Cell Tissue Res.
        
                    2015 Sep;
        
                    361(3).
        
                    doi: 10.1007/s00441-015-2166-z
                            PMID: 25820673
  Tissue-Specific Cultured Human Pericytes: Perivascular Cells from Smooth Muscle Tissue Have Restricted Mesodermal Differentiation Ability.

    Pierantozzi E, Vezzani B, Badin M, Curina C, Severi FM, Petraglia F, Randazzo D, Rossi D, Sorrentino V
        

                    Stem Cells Dev.
        
                    2016 May 1;
        
                    25(9).
        
                    doi: 10.1089/scd.2015.0336
                            PMID: 26956507
  Exercise-induced alterations and loss of sarcomeric M-line organization in the diaphragm muscle of obscurin knockout mice.

    Randazzo D, Blaauw B, Paolini C, Pierantozzi E, Spinozzi S, Lange S, Chen J, Protasi F, Reggiani C, Sorrentino V
        

                    Am J Physiol Cell Physiol.
        
                    2017 Jan 1;
        
                    312(1).
        
                    doi: 10.1152/ajpcell.00098.2016
                            PMID: 27784675
  The potential of obscurin as a therapeutic target in muscle disorders.

    Randazzo D, Pierantozzi E, Rossi D, Sorrentino V
        

                    Expert Opin Ther Targets.
        
                    2017 Sep;
        
                    21(9).
        
                    doi: 10.1080/14728222.2017.1361931
                            PMID: 28756711
  Persistent upregulation of the β-tubulin tubb6, linked to muscle regeneration, is a source of microtubule disorganization in dystrophic muscle.

    Randazzo D, Khalique U, Belanto JJ, Kenea A, Talsness DM, Olthoff JT, Tran MD, Zaal KJ, Pak K, Pinal-Fernandez I, Mammen AL, Sackett D, Ervasti JM, Ralston E
        

                    Hum Mol Genet.
        
                    2019 Apr 1;
        
                    28(7).
        
                    doi: 10.1093/hmg/ddy418
                            PMID: 30535187
  Misplaced Golgi Elements Produce Randomly Oriented Microtubules and Aberrant Cortical Arrays of Microtubules in Dystrophic Skeletal Muscle Fibers.

    Oddoux S, Randazzo D, Kenea A, Alonso B, Zaal KJM, Ralston E
        

                    Front Cell Dev Biol.
        
                    2019;
        
                    7().
        
                    doi: 10.3389/fcell.2019.00176
                            PMID: 31620435 
          Education
              
            **University of Palermo (Italy) and National Council of Researches (Italy)**
Ph.D., 2009

**University of Palermo (Italy)**
B.S., Biological Sciences, 2005, summa cum laude             
                        Experience
              
            **Visiting Fellow**
Light Imaging Section / Office of Science and Technology, NIAMS, NIH, 2014 - 2022

**Postdoctoral Fellow**
University of Siena (Italy), 2010-2014


Last Updated: June 2023


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