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		Search Text: Home/< Back ToThe Science/Stem Cell and Neurovascular Research
  Stem Cell and Neurovascular Research
    The overarching goal of the Laboratory of Stem Cell and Neurovascular Research, led by Dr. Yosuke Mukoyama (Yoh‐suke Mukouyama in PubMed), is to uncover the molecular control of the morphologic processes underlying the branching morphogenesis and patterning of the vascular and nervous systems.
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        Updates from the Laboratory of Stem Cell and Neurovascular Research
    
          Yosuke Mukouyama
  Yosuke Mukoyama, Ph.D.
          Senior Investigator
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      Meet the Team
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  Senior Investigator Research Interests
            
  Research Interests
              Branching morphogenesis is a fundamental attribute of many organ systems. The overarching goal of Dr. Mukouyama’s laboratory is to uncover the molecular control of the morphologic processes underlying the patterning of tubular branching networks, particularly the vascular and nervous systems, which share several anatomic and functional characteristics, and are often patterned similarly in peripheral tissues. These characteristics suggest that there is interdependence between these two networks during tissue development and homeostasis. Thus, Dr. Mukouyama is studying neuronal influences on vascular branching patterns and vascular influences on both neuronal guidance and neural stem cell maintenance. His laboratory approaches these problems using a combination of high-resolution whole-mount imaging, molecular manipulations, advanced genetic perturbations, next-generation sequencing, and in vitro organ culture techniques.By developing a model system of skin vasculature that allows for the direct observation of congruent vascular and neural networks in an anatomically recognizable pattern, Dr. Mukouyama and his colleagues have begun to unravel the neural control of vascular development. Their work has established two distinct developmental mechanisms: nerve-derived VEGF-A controls arterial differentiation, and nerve-derived CXCL12 controls vessel branching and nerve alignment. With a combination of high-resolution whole-mount imaging*in vivo*Ca2+ indicator mice, they are currently examining what happens to sensory activity in the mutants having neuro-vascular mis-patterning in developmental and pathological situations, including obesity-related nerve disorders. These studies will provide novel conceptual advances in the development and maintenance of functional neurovascular wiring.Just as nerves influence vascular patterns in the skin, Dr. Mukouyama and his colleagues have also shown that blood vessels influence nerve patterns in the developing heart. Using whole-mount imaging, they demonstrated that sympathetic axons branch alongside large-diameter coronary veins in the sub-epicardial layer of the dorsal ventricular wall prior to innervating final targets such as coronary arteries and cardiomyocytes in the deeper myocardial layer. This novel neuro-vascular association is established by sequential expression of NGF in the subepicardial venous vascular smooth muscle cells (VSMCs) and myocardial arterial VSMCs of coronary vessels. With an ultra-high-frequency non-invasive imaging, they found abnormal cardiac functions such as irregular cardiac rhythms in the**mutant embryos lacking autonomic nervous system. They are currently examining what happens to the myocardium development and conduction system architecture in the absence of autonomic nervous system and how autonomic nerves affect cardiomyocyte differentiation and maturation. These studies will provide a mechanistic framework for the functional consequence of sympathetic innervation in the developing heart.No examination of neurovascular interactions could neglect the brain. The vasculature component of this specialized niche microenvironment helps to retain neural stem cell potential. Dr. Mukouyama and his colleagues have also found that brain vasculature influences unique distributions of embryonic macrophages including parenchymal microglia, as well as non-parenchymal meningeal and perivascular macrophages. They are currently examining how embryonic macrophages regulate radial glial cells, the primary source of cortical neurons in early brain development. These studies will provide insights into understanding the molecular and cellular basis of the neuro-vascular-immune interactions in the developing brain.These three independent but thematically interrelated projects provide unique opportunities to advance understanding of the dynamic features of both vascular and neuronal branching networks.
  Images






          Triple RNA whole-mount in situ hybridization chain reaction of E8.5 wild-type embryos revealed the expression of Hlf (green), as well as the paraxial mesoderm markers Pax3 (blue) and Eomes (red) in the cephalic region. Koui et al. showed that Hlf-expressing cephalic paraxial mesenchymal cells contribute to the developing brain vascular cells such as endothelial cells and pericytes (Koui et al. Biol Open 11: bio059510, 2022).
      
        Click the image to expand
    A unique expression of hepatic leukemia factor (Hlf) in the cephalic paraxial mesenchyme


        
            Triple RNA whole-mount in situ hybridization chain reaction of E8.5 wild-type embryos revealed the expression of Hlf (green), as well as the paraxial mesoderm markers Pax3 (blue) and Eomes (red) in the cephalic region. Koui et al. showed that Hlf-expressing cephalic paraxial mesenchymal cells contribute to the developing brain vascular cells such as endothelial cells and pericytes (Koui et al. Biol Open 11: bio059510, 2022).


                      Lymphatic vessels in the postnatal brain meninges.
      
        Click the image to expand
    Lymphatic vessels in the postnatal brain meninges.


        
            Using the *Prox1-GFP BAC* transgenic reporter (green) and immunostaining with antibodies to lymphatic markers LYVE-1 (red) and pan-blood vessel marker PECAM-1 (blue), we have carried out whole-mount imaging of dural lymphatic vasculature at postnatal stages. We have found that between birth – postnatal day 13 (P)13, lymphatic vessels extend alongside dural blood vessels from the side of the skull towards the midline. The image was published in Developmental Dynamics (Izen et al. Dev Dyn 247:741-753, 2018).


                      Structural interdependence of blood vessels and nerves to form coordinated branching networks
      
        Click the image to expand
    Structural interdependence of blood vessels and nerves to form coordinated branching networks


        
            EC, endothelial cells; VSMC, vascular smooth muscle cells. Modified from Fig. 3 in James & Mukouyama. Semin Cell Dev Biol 22: 1019-1027, 2011.


                      Nerve-artery alignment in developing skin
      
        Click the image to expand
    Nerve-artery alignment in developing skin


        
            Sensory nerve (green) align with arteries (red) in the developing mouse skin. The image was published in Cell (Mukouyama et al. : 693-705, 2002).


                      Chemokine controls nerve-vessel co-patterning
      
        Click the image to expand
    Chemokine controls nerve-vessel co-patterning


        
            Chemokine receptor expression (red) was restricted to nerve (green)-associated + arteries  (blue). The image was published in Developmental Cell (Li et al. Dev Cell 24: 359-371, 2013).


                      Cardiac axons follow coronary vessels in embryonic heart
      
        Click the image to expand
    Cardiac axons follow coronary vessels in embryonic heart


        
            Cardiac sympathetic axons (green) follow VSMC-associated large-diameter coronary vessels in the subepicardium of the dorsal ventricular wall of the developing mouse heart. The image was selected as the cover of the issue in Development (Nam et al. Development 140: 1475-1485, 2013).


                      Intra-neural hemorrhage in the brain: a mouse model of human CCMs
      
        Click the image to expand
    Intra-neural hemorrhage in the brain: a mouse model of human CCMs


        
            The vascular lumen appears to have ruptured resulting in hemorrhage in conditional mutants as evidenced by erythrocytes (green) outside the vessel enclosure (red). The image was published in Human Molecular Genetics (Cunningham et al. Hum Mol Genet 20: 3198-3206, 2011)


                      Venous expression of EphB1 in embryonic limb skin vasculature
      
        Click the image to expand
    Venous expression of EphB1 in embryonic limb skin vasculature


        
            Whole-mount triple immunofluorescence analysis of forelimb skin of .5 embryos was performed with antibodies to  (green) in combination with the pan-endothelial cell marker PECAM-1 (blue) and the vascular smooth muscle cell (VSMC) marker alpha SMA (red). By .5, arterial vessels are densely covered with VSMCs, whereas less or no VSMC coverage occurs in venous vessels.  expression is restricted to the venous vasculature. No expression is detectable in the arterial and lymphatic vasculature. The image was published in Developmental Dynamics (Li et al. Dev Dyn 2013).


                      Skin lymphangiogenesis
      
        Click the image to expand
    Skin lymphangiogenesis


        
            Whole-mount confocal microscopy reveals that + (blue)/LYVE-1+ (green) lymphatic vessels sprout toward the dorsal midline in .5 mouse dorsal skin. PECAM-1+ blood vessels (red) have reached the midline at this stage. The image was published in Development (James et al. Development 2013).


                      Gut angiogenesis and neurogenesis
      
        Click the image to expand
    Gut angiogenesis and neurogenesis


        
            An embryonic day (E)15.5 whole-mount small intestine stained with antibodies to PECAM1 (blood vessels, blue), TuJ1 (neuronal tubulin, neurons, green), and tyrosine hydroxylase (sympathetic neurons, red). Here, the enteric nervous system (ENS, green) can be seen surrounding the full length of the small intestine. Sympathetic nerves (red and green) project along arteries in the mesentery until they reach the intestinal wall. Upon reaching the ENS, these nerves defasciculate and extend throughout the existing enteric nerve plexus. The image was published in Developmental Dynamics (Hatch & Mukouyama, Dev Dyn 2014).


                      Sema3s-Nrp2 signaling is required for skin lymphangiogenesis
      
        Click the image to expand
    Sema3s-Nrp2 signaling is required for skin lymphangiogenesis


        
            High-resolution whole-mount staining of back skin from E15.5 mutants and control littermate was performed with antibodies to lymphatic markers PROX1 (red) and LYVE1 (green). Sema3f;Sema3g double mutants exhibit increased lymphatic branching (middle image) compared with control littermate (top image). Nrp2 mutants exhibit decreased lymphatic branching and increased lymphatic endothelial cell growth. The image will be published in Biology Open (Uchida et al. Biol Open 2015).


                      Adult ear skin innervation and vascularization
      
        Click the image to expand
    Adult ear skin innervation and vascularization


        
            High resolution whole-mount adult ear skin stained with antibodies to PECAM1 (blood vessels, blue), TuJ1 (neuronal tubulin, neurons, green), and alpha SMA (vascular smooth muscle cells, red). The alignment of Tuj1+ peripheral nerve bundles with large- or middle-diameter blood vessels covered with alpha SMA+ vascular smooth muscle cells. The image was the 8th place in the 2015 Nikon Photomicrography competition.


                      SV patient with Glenn physiology and APCs who had increased angiogenic activity in vitro
      
        Click the image to expand
    SV patient with Glenn physiology and APCs who had increased angiogenic activity in vitro


        
            The image will be published in the Journal of Thoracic and Cardiovascular Surgery (Sandeep et al. J Thorac Cardiovasc Surg. 2015).


                      Some pericytes are of hematopoietic origin in embryonic skin vasculature
      
        Click the image to expand
    Some pericytes are of hematopoietic origin in embryonic skin vasculature


        
            We discovered that the developmental sources of dermal pericytes are heterogeneous and a portion of dermal pericytes has a hematopoietic/myeloid origin. Confocal image obtained from fate-mapping experiments using embryo that have pan-hematopoietic Vav-Cre and R26R-EYFP reporter demonstrates that some NG2+ pericytes (red) associated with PECAM-1+ blood vessels (blue) are also EYFP+ (green), sugesting that EYFP+NG2+ pericytes originate from hematopoietic cells. The image was published in Cell Reports (Yamazaki et al. Cell Rep 2017).


                      Soluble APP negatively regulates NSC growth in culture
      
        Click the image to expand
    Soluble APP negatively regulates NSC growth in culture


        
            Whole-mount immunostaining of SVZ-derived neurospheres with antibodies to a NSC marker Sox2 (red) and a proliferation marker phospho-histone H3 (green). The treatment of soluble amyloid precursor protein (right) suppresses NSC growth in culture, compared to that of control alkaline phosphatase protein (left). The image was published in Development (Sato et al. Development 144: 2730-2736, 2017).


                      High resolution whole-mount tissue-cleared mouse embryo
      
        Click the image to expand
    High resolution whole-mount tissue-cleared mouse embryo


        
            High resolution whole-mount tissue-cleared mouse embryo (embryonic day 13.5) stained with antibodies to PECAM1 (blood vessels, blue) and TuJ1 (neuronal tubulin, neurons, green). The image was selected in the top 100 in the 2019 Nikon Small World competition.


                      High resolution whole-mount tissue-cleared mouse gut
      
        Click the image to expand
    High resolution whole-mount tissue-cleared mouse gut


        
            High resolution whole-mount tissue-cleared mouse gut (embryonic day 13.5) stained with antibodies to PECAM1 (blood vessels, blue), TuJ1 (neuronal tubulin, neurons, red) and TH (tyrosine hydroxylase, sympathetic neurons, green). The image was selected in the top 100 in the 2019 Nikon Small World competition.


                      Whole-mount and ultrasound analysis of mutants lacking autonomic nerves
      
        Click the image to expand
    Whole-mount and ultrasound analysis of mutants lacking autonomic nerves


        
            Whole-mount double immunofluorescence confocal microscopy was performed with the pan-neuronal marker Tuj1 (class III b-tubulin, green) and endothelial cell marker PECAM-1 (red). The*Phox2b-/-* ventricle has a near complete absence of autonomic neurons. M-mode ultrasound analysis of a *Phox2b-/-* embryo shows irregular ventricular contraction (arrows) both in rhythm and magnitude of contraction suggesting ectopic atrial or ventricular focus. The images were published in Ultrasound in Medicine & Biology (Mokshagundam et al. Ultrasound Med Biol 47:751-758, 2020).


                      Coronary Vasculature in Cxcr4 Gain-Of-Function Heart
      
        Click the image to expand
    Coronary Vasculature in Cxcr4 Gain-Of-Function Heart


        
            Whole-mount immunofluorescence confocal microscopy of E15.5 heart wasperformed with antibodies to pan-endothelial cell marker PECAM-1 (green) and venous and capillary marker EMCN (red) to visualize coronary veins in the dorsal subepicardial layer of the ventricular wall. Endothelial cell-specific *Cxcr4* gain-of-function embryo fails to form hierarchical coronary vascular network.
      Triple RNA whole-mount in situ hybridization chain reaction of E8.5 wild-type embryos revealed the expression of Hlf (green), as well as the paraxial mesoderm markers Pax3 (blue) and Eomes (red) in the cephalic region. Koui et al. showed that Hlf-expressing cephalic paraxial mesenchymal cells contribute to the developing brain vascular cells such as endothelial cells and pericytes (Koui et al. Biol Open 11: bio059510, 2022).


                      
Lymphatic vessels in the postnatal brain meninges.


                      
Structural interdependence of blood vessels and nerves to form coordinated branching networks


                      
Nerve-artery alignment in developing skin


                      
Chemokine controls nerve-vessel co-patterning


                      
Cardiac axons follow coronary vessels in embryonic heart


                      
Intra-neural hemorrhage in the brain: a mouse model of human CCMs


                      
Venous expression of EphB1 in embryonic limb skin vasculature


                      
Skin lymphangiogenesis


                      
Gut angiogenesis and neurogenesis


                      
Sema3s-Nrp2 signaling is required for skin lymphangiogenesis


                      
Adult ear skin innervation and vascularization


                      
SV patient with Glenn physiology and APCs who had increased angiogenic activity in vitro


                      
Some pericytes are of hematopoietic origin in embryonic skin vasculature


                      
Soluble APP negatively regulates NSC growth in culture


                      
High resolution whole-mount tissue-cleared mouse embryo


                      
High resolution whole-mount tissue-cleared mouse gut


                      
Whole-mount and ultrasound analysis of mutants lacking autonomic nerves


                      
Coronary Vasculature in Cxcr4 Gain-Of-Function Heart
Featured Publications
                Hepatic leukemia factor-expressing paraxial mesoderm cells contribute to the developing brain vasculature.
            Authors:Koui Y, Ideue T, Boylan M, Anderson MJ, Osato M, Suda T, Yokomizo T, Mukouyama YS.
                                                                                                                        
            Biol Open.
      
                2022 Sep 15;11(9):
        Read Publication
                      Whole-Mount Adult Ear Skin Imaging Reveals Defective Neuro-Vascular Branching Morphogenesis in Obese and Type 2 Diabetic Mouse Models.
            Authors:Yamazaki T, Li W, Yang L, Li P, Cao H, Motegi SI, Udey MC, Bernhard E, Nakamura T, Mukouyama YS
                                                                                                                        
            Sci Rep.
      
                2018 Jan 11;8(1):430
        Read Publication
                      Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature.
            Authors:Yamazaki T, Nalbandian A, Uchida Y, Li W, Arnold TD, Kubota Y, Yamamoto S, Ema M, Mukouyama YS
                                                                                                                        
            Cell Rep
      
                2017 Mar 21;18(12):2991-3004
        Read Publication
                      Coronary veins determine the pattern of sympathetic innervation in the developing heart.
            Authors:Nam J, Onitsuka I, Hatch J, Uchida Y, Ray S, Huang S, Li W, Zang H, Ruiz-Lozano P, Mukouyama YS
                                                                                                                        
            Development
      
                2013 Apr 01;140(7):1475-85
        Read Publication
                      Peripheral Nerve-Derived CXCL12 and VEGF-A Regulate the Patterning of Arterial Vessel Branching in Developing Limb Skin.
            Authors:Li W, Kohara H, Uchida Y, James JM, Soneji K, Cronshaw DG, Zou YR, Nagasawa T, Mukouyama YS
                                                                                                                        
            Dev Cell
      
                2013 Feb 25;24(4):359-71
        Read Publication
                                View More Publications
  Meet the Team

    Yosuke Mukouyama

            Yosuke Mukoyama, Ph.D.
                Senior Investigator
                Yoh-suke Mukouyama, whose legal name is Yosuke Mukoyama, publishes as Yoh-suke Mukouyama. He received his A.B. in pharmacy studies from Tokyo University of Science and his M.S. and Ph.D. in developmental biology from the University of Tokyo. As a student in the laboratory of Atsushi Miyajima, he studied the properties of embryonic endothelial cells and hematopoietic stem cells (HSCs). He did postdoctoral research in the laboratory of David Anderson at the California Institute of Technology where he demonstrated that peripheral nerves direct arterial organization and formation by secreting VEGF; he also studied the properties of neural stem cells (NSCs). Dr. Mukouyama joined the NHLBI as a tenure-track Investigator in 2006. He also serves on the editorial board of Developmental Dynamics and is a member of the International Society for Stem Cell Research and the North American Vascular Biology Organization.

                                View  Mukoyama's Profile
    
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  Krista Gill
    
            Krista Gill, B.S.
        

    Scientific Support Staff

        gillkr@mail.nih.gov
            Wenling Li
    
            Wenling Li, Ph.D.
        

    Staff Scientist

        liw3@mail.nih.gov
            William Kowalski
    
            William Kowalski, Ph.D.
        

    Postdoctoral Fellow

        william.kowalski@nih.gov
            Yuto Koi
    
            Yuta Koui, Ph.D.
        

    Postdoctoral Fellow
            Ryo Sato
    
            Ryo Sato, M.D., Ph.D.
        

    Postdoctoral Fellow
            Sara Gonzalez
    
            Sara Gonzalez, PhD
        

    Postdoctoral Fellow
            Shuxuan Song
    
            Shuxuan Song
        

    Predoctoral Fellow

        shuxuan.song@nih.gov
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        **Post-baccalaureate and Graduate students**If you are looking for a Post-baccalaureate IRTA position or graduate student position in the GPP program (e.g. NIH-Oxford/Cambridge Scholars Program), please contact me with your previous research experiences. We can set up a time to meet or SKYPE. I look forward to your motivation and enthusiasm about research!
  Alumni
        

Takumi Sogo
        

    Guest Researcher/Student from Kyoto Univ. Japan
                                        2024

      -
            2024
        Takumi Sogo  is currently a Medical Student at Kyoto University, School of Medicine, Japan.
      Rino Kimura
        

    Guest Researcher/Student from Univ. the Ryukyus, Japan
                                        2024

      -
            2024
        Rino Kimura  is currently a Medical Student at Univ. the Ryukyus, Faculty of Medicine, Japan.
      Rina Shimada
        

    Guest Researcher/Student from Tohuku Univ, Japan
                                        2023

      -
            2023
        Rina Shimada  is currently a Medical Student at Tohoku University, School of Medicine, Japan.
      Keigo Onizawa
        

    Guest Researcher/Student from Kyoto Univ, Japan
                                        2023

      -
            2023
        Keigo Onizawa  is currently a Medical Student at Kyoto University, School of Medicine, Japan.
      Ryusei Abe
        

    Guest Researcher/Student from Juntendo Univ, Japan
                                        2023

      -
            2023
        Ryusei Abe  is currently a Medical Student at Juntendo University, School of Medicine, Japan.
      Linda Leatherbury, M.D.
        

    Visiting Pediatric Cardiologist
                                        2016

      -
            2023
        Linda Leatherbury, M.D. is currently a retired cardiologist.
      Tyler Sakamoto
        

    Summer Student from Harvard
                                        2022

      -
            2022
        Tyler Sakamoto  is currently a Undergraduate Student at Harvard University.
      Shravani Vatti
        

    Postbaccalaureate IRTA
                                        2019

      -
            2022
        Shravani Vatti  is currently a PhD Candidate Student  at the Pharmacology Program at Cornell University.
      Katherine Lipsius
        

    RADM Helena O. Mishoe Fellowship Postbaccalaureate IRTA
                                        2019

      -
            2022
        Katherine Lipsius  is currently a MD/PhD Candidate Student  at Indiana University School of Medicine.
      Jeffrey Hayashi
        

    Summer Student from U. Portland
                                        2022

      -
            2022
        Jeffrey Hayashi  is currently a Medical Student at University of Hawaii, John A. Burns School of Medicine.
      Sho Nakamura
        

    Guest Researcher/Student from Tohoku Univ, Japan
                                        2019

      -
            2019
        Sho Nakamura  is currently a Medical Student at Tohoku University, School of Medicine, Japan.
      Chang Liu
        

    Visiting Fellow
                                        2015

      -
            2019
        Chang Liu  is currently a senior scientist at Sarepta Therapeutics, Inc. Durham.
      Atsufumi Yoshida
        

    Guest Researcher/Student from Kumamoto Univ, Japan
                                        2019

      -
            2019
        Atsufumi Yoshida  is currently a Medical Student at Kumamoto University, School of Medicine, Japan.
      Deepa Mokshagundam, M.D.
        

    NIH-CNMC Clinical Fellow
                                        2016

      -
            2019
        Deepa Mokshagundam, M.D. is currently a Advanced Fellow at Pediatric Heart Failure and Heart Transplant, St Louis Children's Hospital, Department of Pediatric Cardiology, One Children's Place, St Louis.
      Mitsunori Nomura, Ph.D.
        

    Visiting Fellow
                                        2018

      -
            2019
        Mitsunori Nomura, Ph.D. is currently a Senior Research Fellow at Buck Institute, University of California, San Francisco.
      Mishal Rao
        

    Special Volunteer/Postbaccalaureate
                                        2018

      -
            2019
        Mishal Rao  is currently a Graduate Student in the Integrative Systems Biology Graduate Program at University of Pittsburgh School of Medicine.
      Nathan Burns
        

    Postbaccalaureate IRTA
                                        2017

      -
            2019
        Nathan Burns  is currently a Graduate Student in the Molecular Biology Program at University of Utah.
      Yuya Sato, Ph.D.
        

    Research Fellow
                                        2016

      -
            2019
        Yuya Sato, Ph.D. is currently a senior scientist at Knowledge Palette, Inc. Kobe, Japan.
      Ryan Phelps
        

    Summer Student from UCSF
                                        2018

      -
            2018
        Ryan Phelps  is currently a Medical Student at UC San Francisco Medical School.
      Aya Kudo
        

    Guest Researcher/Student from Kumamoto Univ, Japan
                                        2018

      -
            2018
        Aya Kudo  is currently a Medical Student at Kumamoto University, School of Medicine, Japan.
      Rebecca Izen
        

    Postbaccalaureate IRTA
                                        2015

      -
            2018
        Rebecca Izen  is currently a Graduate Student, Developmental and Regenerative Biology, Biological and Biomedical Sciences Program at Harvard Medical School.
      Iris Garcia-Pak
        

    Postbaccalaureate IRTA
                                        2015

      -
            2018
        Iris Garcia-Pak  is currently a MD/PhD Candidate Student at UC San Diego School of Medicine.
      Yoshihiko Morisue
        

    Guest Researcher/Student from Tohoku Univ, Japan
                                        2017

      -
            2018
        Yoshihiko Morisue  is currently a Medical Student at Tohoku University Medical School, Japan.
      Tomoko Yamazaki, Ph.D.
        

    Visiting Fellow
                                        2013

      -
            2017
        Tomoko Yamazaki, Ph.D. is currently a Scientist at Tumor Microenvironment Laboratory, Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center.
      Yoko Nishinaka-Arai, Ph.D.
        

    Guest Researcher
                                        2017

      -
            2017
        Yoko Nishinaka-Arai, Ph.D. is currently a Postdoctoral Fellow at Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Japan.
      Honomi Kawase
        

    Guest Researcher/Student from Nagoya City Univ, Japan
                                        2017

      -
            2017
        Honomi Kawase  is currently a Medical Student at Nagoya City University Medical School, Japan.
      Yutaka Uchida, Ph.D.
        

    Visiting Fellow and Research Fellow
                                        2008

      -
            2016
        Yutaka Uchida, Ph.D. is currently a Research Assistant Professor, Department of Immunology and Cell Biology at Osaka University School of Medicine, Japan.
      Kevin Wu
        

    Summer Student from Johns Hopkins
                                        2016

      -
            2016
        Kevin Wu  is currently a Undergraduate student in Chemical and Biomolecular Engineering major at Johns Hopkins University.
      Jessica Choi
        

    Postbaccalaureate IRTA
                                        2014

      -
            2016
        Jessica Choi  is currently a Graduate Student at Duke University, Master of Science in Global Health.
      Mano Soshi
        

    Guest Researcher/Student from Osaka Med, Japan
                                        2016

      -
            2016
        Mano Soshi  is currently a Student  at Osaka Medical College, Japan.
      Nefthi Sandeep, M.D.
        

    NIH-CNMC Clinical Fellow
                                        2013

      -
            2015
        Nefthi Sandeep, M.D. is currently a Pediatric and Fetal Cardiologist at Pediatric Cardiology, Northwest Congenital Heart Care.
      David Kim
        

    Guest Researcher/Student from Colgate
                                        2015

      -
            2015
        David Kim  is currently a Program Coordinator at The San Francisco Foundation.
      Brian Shepherd
        

    Postbaccalaureate IRTA
                                        2013

      -
            2015
        Brian Shepherd  is currently a Graduate student at University of Oklahoma Health Sciences Center.
      Aparna Sajja
        

    Summer Student from George Washington Univ.
                                        2012

      -
            2015
        Aparna Sajja  is currently a completing the accelerated seven-year BA/MD track at The George Washington University.
      Aleksandra Kazimiera Staniszewska
        

    Guest Research/Student from Univ. Aberdeen, UK
                                        2015

      -
            2015
        Aleksandra Kazimiera Staniszewska  is currently a Academic Foundation Programme Trainnee at Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, U.K..
      Izumi Onitsuka, Ph.D.
        

    Visiting Fellow
                                        2009

      -
            2014
        Izumi Onitsuka, Ph.D. is currently a Postdoctoral Associate, Department of Animal and Avian Sciences at University of Maryland.
      Jennifer James, Ph.D.
        

    Postdoctoral IRTA
                                        2009

      -
            2014
        Jennifer James, Ph.D. is currently a Biology teacher at Thomas Jefferson High School for Science and Technology.
      John Hatch
        

    Postbaccalaureate IRTA, Summer student and ARRA-funded Summer Student from UVA
                                        2009

      -
            2014
        John Hatch  is currently a Graduate student at Harvard.
      Tomoki Maetani
        

    Guest Researcher/Student from Kyoto Univ, Japan
                                        2013

      -
            2013
        Tomoki Maetani  is currently a Resident Doctor at Kyoto University Hospital, Japan.
      Akihiro Kikuya
        

    Guest Researcher/Student from Kyoto Univ, Japan
                                        2013

      -
            2013
        Akihiro Kikuya  is currently a Resident Doctor at Tazuke Kofukai Medical Research Institute Kitano Hospital, Japan.
      Suzanne Abdelazim
        

    Postbaccalaureate IRTA
                                        2012

      -
            2013
        Suzanne Abdelazim  is currently a Medical student at Philadelphia College of Osteopathic Medicine.
      Yoshiaki Kubota, M.D., Ph.D.
        

    Guest Researcher
                                        2012

      -
            2012
        Yoshiaki Kubota, M.D., Ph.D. is currently a Professor, Department of Anatomy at Keio University School of Medicine, Japan.
      Ani Nalbandian
        

    Postbaccalaureate IRTA
                                        2010

      -
            2012
        Ani Nalbandian  is currently a Postdoctoral Residency Fellow  at Columbia University Medical Center, New York Presbyterian Hospital.
      Lansdale Henderson
        

    Guest Researcher/Student
                                        2008

      -
            2010
        Lansdale Henderson  is currently a Graduate Student at Johns Hopkins School for Advanced International Studies (SAIS), Bologna, Italy.
      Matan Setton
        

    HHMI-NIH Research Scholar from Duke Medical School
                                        2009

      -
            2010
        Matan Setton  is currently a Fellow at Pediatric Cardiology at Boston Children's Hospital.
      Joseph Nam
        

    Postbaccalaureate IRTA
                                        2007

      -
            2011
        Joseph Nam  is currently a Pediatric dental speciality residency at St. Barnabas Hospital in Bronx.
      Joseph Msefya
        

    BRTP Postbaccalaureate IRTA and BRTP Summer student
                                        2008

      -
            2010
        Joseph Msefya  is currently a Platoon Leader; Middle School Science Teacher at MDARNG, HHC 58 EXPED MI BDE; Newport Mill Middle School.
      Erin O’Donnell
        

    Postbaccalaureate IRTA
                                        2008

      -
            2010
        Erin O’Donnell  is currently a Resident Pediatrics at Cincinnati Children's Hospital Medical Center.
      Michelle B. Eckstein
        

    Animal Technician
                                        2008

      -
            2009
        Michelle B. Eckstein  is currently a Program Manager at Division of Veterinary Resources at the NIH Animal Center, SoBran Bioscience.
      Charity Lee
        

    Summer student from Univ. Maryland
                                        2009

      -
            2009
        Charity Lee  is currently a Medical student at University of Miami Miller School of Medicine.
      Jingqiong Hu, Ph.D.
        

    Visiting Fellow
                                        2007

      -
            2009
        Jingqiong Hu, Ph.D. is currently a Professor, in Stem Cell Center at Wuhan Union Hospital, Hubei, China.
      Xuan Chi, Ph.D.
        

    Postdoctoral IRTA
                                        2008

      -
            2008
        Xuan Chi, Ph.D. is currently a Toxicologist, Office of New Drugs, Center for Drug Evaluation and Research at FDA.
      Bon-Nyeo Koo, M.D., Ph.D.
        

    Visiting Fellow
                                        2007

      -
            2008
        Bon-Nyeo Koo, M.D., Ph.D. is currently a Professor in the Department of Anesthesiology at Yonsei University College of Medicine, Korea.
      Kosha Soneji
        

    Postbaccalaureate IRTA
                                        2006

      -
            2008
        Kosha Soneji  is currently a Obstetrics and Gynecology Physician at Kaiser Permanente, Panorama City.
      Bernadette Nebus
        

    Animal Technician
                                        2006

      -
            2008
        Bernadette Nebus  is currently a Supervisor of Primary Cell Manufacturing at Life Technologies.
      Heesuk Zang, Ph.D.
        

    Visiting Fellow
                                        2006

      -
            2008
        Heesuk Zang, Ph.D. is currently a Partner at Innovation Consulting Services, Inc..
      Steven Kim, Ph.D.
        

    Postdoctoral IRTA Fellow
                                        2006

      -
            2007
        Steven Kim, Ph.D. is currently a Business at home.

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