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          About NIAMS
          Jorge Romo-Tena, M.D., Ph.D.





Jorge Romo-Tena, M.D., Ph.D.


Postdoctoral Fellow
    Systemic Autoimmunity Branch Image
              Headshot of a man outside in casual attire. 
            Contact Information

                                                  301-496-0517
                
                                                9000 Rockville Pike
                  
            10 Center Drive
      
                  
            Building 10, Room 12S253
      
                                   Bethesda MD 20892
                
                                                jorge.romotena2@nih.gov 
                                          Media Resources
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                headshot-jorge-romo-tena.jpg 
                Summary
          Jorge Romo-Tena, M.D., Ph.D., completed his internal medicine and rheumatology fellowships at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico. In parallel with his clinical training, Dr. Romo-Tena's keen interest in research encouraged him to enroll in a Master's in Medical Sciences program, where he studied molecular defects that could contribute to the defective function of regulatory T cells in patients with systemic lupus erythematosus. He concluded this project successfully and graduated with honors. His work earned the Rosenkranz Research Award, a highly competitive prize for the best biomedical research performed in Mexico.Dr. Romo-Tena continued his research training by enrolling in a Ph.D. program. His thesis aimed to unravel a complex signaling network whose abnormal function may underlie the pathological behavior of endothelial cells in inflammatory diseases. In 2019, he joined the Systemic Autoimmunity Branch at NIAMS as a Fulbright Visiting Scholar and as part of the NIH-Graduate Partnerships Program.After completing his Ph.D., he started his postdoctoral fellowship to investigate CAR-T cells in a murine lupus model and defects in vascular biology and their connection with post-translational modifications in systemic autoimmune diseases. In 2023, Dr. Romo-Tenawas recognized by the NIH with a Fellows Award for Research Excellence (FARE).
        
                  Research Statement
          
            Dr. Romo-Tena is particularly interested in the defects in vascular biology and their connection with post-translational modifications that can contribute to the pathogenesis of systemic autoimmune diseases. 

            Scientific Publications
              Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis.

    Richoz N, Tuong ZK, Loudon KW, Patiño-Martínez E, Ferdinand JR, Portet A, Bashant KR, Thevenon E, Rucci F, Hoyler T, Junt T, Kaplan MJ, Siegel RM, Clatworthy MR
        

                    JCI Insight.
        
                    2022 Nov 8;
        
                    7(21).
        
                    doi: 10.1172/jci.insight.159751
                            PMID: 36345939
  Neutrophils as Drivers of Immune Dysregulation in Autoimmune Diseases with Skin Manifestations.

    Nakabo S, Romo-Tena J, Kaplan MJ
        

                    J Invest Dermatol.
        
                    2022 Mar;
        
                    142(3 Pt B).
        
                    doi: 10.1016/j.jid.2021.04.014
                            PMID: 34253374
  RNA Externalized by Neutrophil Extracellular Traps Promotes Inflammatory Pathways in Endothelial Cells.

    Blanco LP, Wang X, Carlucci PM, Torres-Ruiz JJ, Romo-Tena J, Sun HW, Hafner M, Kaplan MJ
        

                    Arthritis Rheumatol.
        
                    2021 Dec;
        
                    73(12).
        
                    doi: 10.1002/art.41796
                            PMID: 33983685
  Immunometabolism in the pathogenesis of systemic lupus erythematosus: an update.

    Romo-Tena J, Kaplan MJ
        

                    Curr Opin Rheumatol.
        
                    2020 Nov;
        
                    32(6).
        
                    doi: 10.1097/BOR.0000000000000738
                            PMID: 32826478
  Factors associated with remission in patients with systemic lupus erythematosus: new insights into a desirable state.

    Romo-Tena J, la Garza RR, Bartnicki-Navarrete I, Alcocer-Varela J, Gómez-Martin D
        

                    Clin Rheumatol.
        
                    2018 Nov;
        
                    37(11).
        
                    doi: 10.1007/s10067-018-4226-8
                            PMID: 30056524
  Lys63-polyubiquitination by the E3 ligase casitas B-lineage lymphoma-b (Cbl-b) modulates peripheral regulatory T cell tolerance in patients with systemic lupus erythematosus.

    Romo-Tena J, Rajme-López S, Aparicio-Vera L, Alcocer-Varela J, Gómez-Martín D
        

                    Clin Exp Immunol.
        
                    2018 Jan;
        
                    191(1).
        
                    doi: 10.1111/cei.13054
                            PMID: 28940360
  CTLA-4 and autoimmunity: new insights into the dual regulator of tolerance.

    Romo-Tena J, Gómez-Martín D, Alcocer-Varela J
        

                    Autoimmun Rev.
        
                    2013 Oct;
        
                    12(12).
        
                    doi: 10.1016/j.autrev.2013.07.002
                            PMID: 23851140
  Casitas B lineage lymphoma b is a key regulator of peripheral tolerance in systemic lupus erythematosus.

    Gómez-Martín D, Ibarra-Sánchez M, Romo-Tena J, Cruz-Ruíz J, Esparza-López J, Galindo-Campos M, Díaz-Zamudio M, Alcocer-Varela J
        

                    Arthritis Rheum.
        
                    2013 Apr;
        
                    65(4).
        
                    doi: 10.1002/art.37833
                            PMID: 23280105 
          Education
              
            **Universidad Nacional Autónoma de México (UNAM)**Ph.D., Science (2023)**Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ)**Rheumatology Fellowship (2017)**Universidad Nacional Autónoma de México (UNAM)**M.Sc. (2016)**Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ)**Internal Medicine Fellowship (2015)**Universidad Nacional Autónoma de México (UNAM)**M.D. (2011)             
                        Experience
              
            **Postdoctoral Fellowship**National Institutes of Health (2023-present)**Predoctoral Fellowship**National Institutes of Health (2021-2023)**Guest Researcher**National Institutes of Health (2019-2021)**Professor of Medicine**Universidad Autónoma Metropolitana (UAM) (2018-2019)


Last Updated: September 2023


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