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		Search Text: Clinical Trials
					
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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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      How Clinical Trials Work
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Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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CLEARAnemiaAplastic AnemiaArrhythmiasAtrial FibrillationBleeding DisordersBlood Clotting DisordersCardiomyopathyCongenital Heart DefectsCOPDCoronary Artery Bypass GraftingCoronary Heart DiseaseCystic FibrosisHeart-Healthy LivingHeart FailureHeart SurgeryHeart Valve DiseasesHemolytic AnemiaHigh Blood PressureIdiopathic Pulmonary FibrosisInterstitial Lung DiseasesLAMLung Disease TreatmentsOverweight and ObesityPhysical Activity and Your HeartPneumoniaPulmonary HypertensionRespiratory FailureSickle Cell DiseaseSleep ApneaSleep Deprivation and DeficiencySmoking and Your HeartStrokeTests for Lung DiseaseTreatments for Blood DisordersVenous Thromboembolism

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Showing 1 - 10 out of 62 results
      
      The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial
      Recruiting
                          Multiple Locations
        DIVA is a pragmatic randomized clinical trial (RCT) to determine: among (P) preterm infants born 24-27 6/7 weeks gestation undergoing extubation from mechanical ventilation, whether (I) Non-invasive neurally adjusted ventilatory assist (NIV-NAVA) (C) compared with Non-synchronized nasal intermittent positive pressure ventilation (NS-NIPPV), will reduce the incidence of (O) extubation failure within (T) 5 days (120 hours) of extubation.
      Interstitial Lung Diseases
              Lung Disease Treatments
                          Child
    Electronic Nicotine Delivery Devices and Potential Progression to Acute Lung Injury
      Recruiting
                          Pennsylvania
        This is an observational - data and specimen collection study. There have been increasing reports of vaping-induced lung injury, including severe lung injury and rare cases of death. The mechanism by which vaping contributes to lung injury in susceptible persons is unknown, as is impact on chronic lung disease. The investigators aim to identify individuals with chronic electronic nicotine delivery device (ENDD) exposure and matched controls within our ongoing cohort of HIV+ and HIV-uninfected individuals, collect PFT data, bank respiratory and stool samples and collect clinical data for studies of clinical risk, inflammation, biomarkers, and the microbiome in the identification and modification of risk of progression to lung injury or chronic pulmonary disease.
      Interstitial Lung Diseases
              Tests for Lung Disease
                          Adult, Older Adult
                                      Accepting Healthy Volunteers
    Fibrosis and the Fontan
      Recruiting
                          Pennsylvania
        The purpose of this study is to non-invasively characterize the fibrotic consequences of single ventricle physiology, its possible solution and effect on lymphatics. This project investigates the response to acute imposition of Fontan hemodynamics by examining the interrelationship between liver and cardiac fibrosis/dysfunction and lymphatic congestion along with a pilot trial of the antifibrotic agent, spironolactone, to prevent these consequences and to determine if MRI can discern these differences. The combination of serum biomarkers and MRI form a powerful non-invasive tool in putting together this complicated web of dysfunction.
      Cystic Fibrosis
                          Child
    tPA by Endovascular Administration for the Treatment of Submassive PE Using CDT for the Reduction of Thrombus Burden
      Recruiting
                          Multiple Locations
        The BashirTM Endovascular Catheter has been designed to administer therapeutic agents in the peripheral vasculature. Because of the unique design of the catheter, with its six expandable infusion limbs, the BashirTM Endovascular Catheter has the ability to: 1. Create a much larger central channel for blood flow, thereby utilizing the body's own endogenous fibrinolytic agents to lyse the clot, and 2. Greatly enhance the radial dispersion of a catheter-administered thrombolytic agent throughout the thrombus. Expansion of the multiple arms of the basket in the infusion catheter causes fissuring of the clot. The net result is that a greater surface area of clot is exposed to both endogenous and exogenously administered lytic agents, thereby promoting clot dissolution.
      Blood Clotting Disorders
                          Adult, Older Adult
    NAD+ and Exercise in FA
      Recruiting
                          Pennsylvania
        Do you or your child have Friedrich's Ataxia? This study is looking into a supplement in the form of vitamin B3 plus exercise can help the body better use oxygen for people with Friedrich’s Ataxia. You must be 10 to 40 years old to join. Participants may be asked to take the daily supplement, exercise, or do both during the study. The study is taking place in Philadelphia, Pennsylvania.
      Physical Activity and Your Heart
                          Child, Adult
    Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome
      Recruiting
                          New York
              Pennsylvania
        22q11.2 deletion syndrome is a genetic disorder that can cause heart defects, facial abnormalities, and developmental and learning disabilities. The severity of the disorder can vary widely among people. This study will analyze DNA from people with 22q11.2 deletion syndrome to identify genetic variations that may affect the severity of the disorder.
      Congenital Heart Defects
                          All Ages
    PET Image in PAH Patients
      Recruiting
                          Pennsylvania
        Investigators will conduct in-human PET imaging of 18F-fluoroglutamine (18F-FGln) in patients with PAH to compare glutamine uptake to that of controls.
      Pulmonary Hypertension
                          Adult, Older Adult
                                      Accepting Healthy Volunteers
    Acute Effects of E-Cigarette Aerosol Inhalation
      Recruiting
                          Pennsylvania
        The purpose of this study is to examine the acute effects of nicotine free electronic cigarette aerosol on vascular function in healthy, non-smokers.
      Smoking and Your Heart
                          Adult
                                      Accepting Healthy Volunteers
    The Pregnancy 24/7 Cohort Study
      Recruiting
                          Iowa
              Pennsylvania
              West Virginia
        This study will leverage state-of-the-art, 24-hour behavior assessment in each trimester of pregnancy and examine associations with adverse pregnancy outcomes to inform guidelines and future interventions designed to improve women's pregnancy and long-term cardiovascular health.
      Physical Activity and Your Heart
              Sleep Deprivation and Deficiency
                          Adult
                                      Accepting Healthy Volunteers
                                              Female
    American Lung Association (ALA) Lung Health Cohort
      Recruiting
                          Multiple Locations
        The objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.
      Adult
                                      Accepting Healthy Volunteers
  
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