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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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Sickle Cell DiseaseSleep ApneaSleep Deprivation and DeficiencySleep StudiesSmoking and Your HeartStrokeTests for Lung DiseaseThalassemiaThe LungsTranscatheter Aortic Valve Replacement (TAVR)Treatments for Blood DisordersVasculitisVenous ThromboembolismVentilator/Ventilator SupportWhat Is Physical Activity?Women and Heart Disease

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Clear AllSickle Cell Disease
Showing 1 - 10 out of 32 results
      
      The BENeFiTS Trial in Beta Thalassemia Intermedia
      Recruiting
                          California
              Massachusetts
              New York
        his trial will evaluate an oral drug discovered in a high throughput screen, which increases fetal globin protein (HbF and red blood cells expressing HbF)and messenger ribonucleic acid (mRNA) to high levels in anemic nonhuman primates and in transgenic mice.
      Sickle Cell Disease
                          Adult, Older Adult
    A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease
      Recruiting
                          Massachusetts
        Sickle Cell Disease (SCD) impairs oxygen transport to tissue and causes endothelial injury. Thus, therapeutic interventions aim to improve both, but there is an unmet need for biomarkers to determine when intervention is necessary and evaluate the effectiveness of the chosen intervention in individual patients. This study proposes to monitor SCD and its treatment through their impact on cerebral hemodynamics, as the brain is one of the most vulnerable and consequential targets of the disease. Specifically, this study will optimize quantitative magnetic resonance imaging (MRI) and advanced optical spectroscopy techniques such as frequency-domain near-infrared and diffuse correlation spectroscopies (FDNIRS-DCS) to monitor 1) cerebral oxygen transport with measures of cerebral blood flow (CBF), cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen consumption (CMRO2) and 2) endothelial function with cerebrovascular reactivity (CVR).
      Sickle Cell Disease
                          Child, Adult
    A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001)
      Recruiting
                          Multiple Locations
        The main goal of this study is to determine whether the treatment will lead to a complete absence of severe vaso-occlusive events (VOEs) in patients with severe SCD.
      Sickle Cell Disease
                          Child, Adult
    Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia
      Recruiting
                          Maryland
        Are you or your child at least 13 years old and have sickle cell disease?
                    In this stidy, researchers are trying to find out if a new medication improves the success of a blood stem cell transplant. People 13 years old or older who are eligible for a blood stem cell transplant to treat sickle cell disease may be able to participate. Healthy family members over age 13 who are matched to transplant recipients are also needed to donate blood for the study. This study is taking place at the National Institutes of Health Clinical Center in Bethesda, Maryland.
      Thalassemia
              Sickle Cell Disease
                          All Ages
                                      Accepting Healthy Volunteers
    Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain
      Recruiting
                          New York
        This study is seeking to determine the safety and tolerability of dronabinol use in adults with SCD compared to placebo.
      Sickle Cell Disease
                          Adult, Older Adult
    Exploring Near Infrared Spectroscopy (NIRS) Technologies for Assessment of Muscle Physiology, Tissue Oxygenation, and Blood Flow in Patients With Sickle Cell Disease (SCD)
      Recruiting
                          Maryland
        Are you at least 18 years old and have sickle cell disease and taking the medication Hydroxyurea?
                    For this study, researchers testing are tool for measuring oxygen levels, blood flow, and the makeup of skin and muscle in patients with sickle cell disease.  To participate in this study, you must be at least 18 years old and have sickle cell disease and also be taking the medication Hydroxyurea.  This study is taking place at the National Institutes of Health Clinical Center in Bethesda, Maryland.
      Sickle Cell Disease
                          Adult, Older Adult
    Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies
      Recruiting
                          Maryland
        Are you at least 18 years old and have sickle cell disease?
                    People with sickle cell disease often have problems with their heart, brain, kidneys, liver, and lungs as they age. These problems may improve after transplant. Researchers in this study are trying to learn how and why this happens. To participate in this study, you must be at least 18 years old and have sickle cell disease. You must also have a history of problems with your heart, lungs, or other criteria that the study doctor will discuss with you. This study is taking place at the National Institutes of Health Clinical Center in Bethesda, Maryland.
      Sickle Cell Disease
                          Adult, Older Adult
    Telemedicine for Children With Sickle Cell Disease
      Recruiting
                          Indiana
        The purpose of this study is to learn more about how the use of two different types of telemedicine (distance medical care) can address barriers to receiving comprehensive sickle cell care, and whether care can be improved.
      Sickle Cell Disease
                          All Ages
    RHD Genotype Matching for Anti-D
      Recruiting
                          Pennsylvania
        This is a pilot study to evaluate the feasibility and safety of providing RH genotype matched D+ Red Blood Cells (RBCs) to chronically transfused patients with sickle cell disease (SCD) who type D+ but have formed anti-D and are currently transfused with D- RBC (Red Blood Cell) units.
      Sickle Cell Disease
                          All Ages
    Cooperative Assessment of Late Effects for SCD Curative Therapies (COALESCE)
      Recruiting
                          Georgia
              Maryland
              Tennessee
        The primary goal of this study is to determine whether curative therapies for individuals with SCD will result in improved or worsening heart, lung, and kidney damage when compared to individuals with SCD receiving standard therapy. The investigators will also explore whether certain genes are associated with a good or bad outcome after curative therapy for SCD.
      Sickle Cell Disease
                          All Ages
  
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