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          About NIAMS
          Baishakhi Ghosh, M.Sc., Ph.D.





Baishakhi Ghosh, M.Sc., Ph.D.


Research Fellow
    Cutaneous Leukocyte Biology Section Image
              Headshot of a young Indian woman, outside. 
            Contact Information

                                                  301-827-1724
                
                                                10 Center Drive
                  
            Building 10, Room 12N256
      
                  
                                   Bethesda MD 20892
                
                                                baishakhi.ghosh@nih.gov 
                Summary
          Baishakhi Ghosh, Ph.D., embarked on a profound worldwide educational expedition, immersing herself in the intricate tapestry of diseases using an interdisciplinary approach. Her journey ignited during her undergraduate studies at St. Joseph’s University (Bangalore, India) in 2008, where she systematically reviewed literature relating to the epidemiological statistics of Hepatitis B in India. This initial spark evolved into Dr. Ghosh's master’s degree at Aston University (Birmingham, United Kingdom) in 2011, where she meticulously profiled cytokines and chemokines released from epithelial cells derived from patients with lung adenocarcinoma. This exploration further unraveled the complexities of disease mechanisms.

From 2013 to 2018, Dr. Ghosh pursued her Ph.D. at Symbiosis International (Deemed University, Pune, India), centered around the immunological interplay of sputum microbial flora and macrophage phagocytosis within the non-smoker chronic obstructive pulmonary disease (COPD) population in India. This endeavor resonated harmoniously with institutions such as the Chest Research Foundation (Pune, India), KEM Hospital Research Centre – Vadu Rural Health Program (Pune, India), and Imperial College of London (London, United Kingdom) in a collaborative symphony. Continuing her journey from 2018 to 2023, Dr. Ghosh pursued her immunological voyage as a post-doctoral fellow at Johns Hopkins Bloomberg School of Public Health (Baltimore, MD). During this period, she focused on unraveling the mysteries of epithelial plasticity, contributing significantly to our understanding of respiratory pathophysiology.

In July 2023, Dr. Ghosh joined NIAMS as a research fellow, further enriching her journey. Her role now involves evaluating the cutaneous vasculature immunological niche and its vital role in systemic health.
        
                  Research Statement
          
            The largest organ in our body is the skin. It performs several functions, including shielding our internal organs from external influences. It is also an essential component of the immune system. Perturbations in skin immunity can lead to a spectrum of diseases which may seriously affect overall bodily function.

Currently, Dr. Ghosh is focusing on evaluating the immunological niche within the cutaneous vasculature and its significance in systemic health. Utilizing cutting-edge technology, she hopes to unveil the intricacies of the skin's function in the immune system. Her research encompasses a comprehensive study of the latest advancements, and aims to unravel the underlying mechanisms responsible for skin diseases arising from immune-related irregularities. This endeavor holds the potential to drive innovations in therapeutic strategies and deepen our comprehension of the pathogenesis of skin disorders. 

            Scientific Publications
              SARS-CoV-2 infection alters mitochondrial and cytoskeletal function in human respiratory epithelial cells mediated by expression of spike protein.

    Yeung-Luk BH, Narayanan GA, Ghosh B, Wally A, Lee E, Mokaya M, Wankhade E, Zhang R, Lee B, Park B, Resnick J, Jedlicka A, Dziedzic A, Ramanathan M, Biswal S, Pekosz A, Sidhaye VK
        

                    mBio.
        
                    2023 Aug 31;
        
                    14(4).
        
                    doi: 10.1128/mbio.00820-23
                            PMID: 37504520
  Loss of E-cadherin is causal to pathologic changes in chronic lung disease.

    Ghosh B, Loube J, Thapa S, Ryan H, Capodanno E, Chen D, Swaby C, Chen S, Mahmud S, Girgis M, Nishida K, Ying L, Chengala PP, Tieng E, Burnim M, Wally A, Bhowmik D, Zaykaner M, Yeung-Luk B, Mitzner W, Biswal S, Sidhaye VK
        

                    Commun Biol.
        
                    2022 Oct 29;
        
                    5(1).
        
                    doi: 10.1038/s42003-022-04150-w
                            PMID: 36309587
  HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPD.

    Horndahl J, Svärd R, Berntsson P, Wingren C, Li J, Abdillahi SM, Ghosh B, Capodanno E, Chan J, Ripa L, Åstrand A, Sidhaye VK, Collins M
        

                    PLoS One.
        
                    2022;
        
                    17(10).
        
                    doi: 10.1371/journal.pone.0266310
                            PMID: 36223404
  Phenotypic Epithelial Changes in Laryngotracheal Stenosis.

    Lina IA, Tsai HW, Berges AJ, Ospino RA, Davis RJ, Motz KM, Collins S, Ghosh B, Sidhaye V, Gelbard A, Hillel AT
        

                    Laryngoscope.
        
                    2022 Nov;
        
                    132(11).
        
                    doi: 10.1002/lary.30040
                            PMID: 35141889
  Epithelial plasticity in COPD results in cellular unjamming due to an increase in polymerized actin.

    Ghosh B, Nishida K, Chandrala L, Mahmud S, Thapa S, Swaby C, Chen S, Khosla AA, Katz J, Sidhaye VK
        

                    J Cell Sci.
        
                    2022 Feb 15;
        
                    135(4).
        
                    doi: 10.1242/jcs.258513
                            PMID: 35118497
  Effect of sub-chronic exposure to cigarette smoke, electronic cigarette and waterpipe on human lung epithelial barrier function.

    Ghosh B, Reyes-Caballero H, Akgün-Ölmez SG, Nishida K, Chandrala L, Smirnova L, Biswal S, Sidhaye VK
        

                    BMC Pulm Med.
        
                    2020 Aug 12;
        
                    20(1).
        
                    doi: 10.1186/s12890-020-01255-y
                            PMID: 32787821
  Strong correlation between air-liquid interface cultures and in vivo transcriptomics of nasal brush biopsy.

    Ghosh B, Park B, Bhowmik D, Nishida K, Lauver M, Putcha N, Gao P, Ramanathan M Jr, Hansel N, Biswal S, Sidhaye VK
        

                    Am J Physiol Lung Cell Mol Physiol.
        
                    2020 May 1;
        
                    318(5).
        
                    doi: 10.1152/ajplung.00050.2020
                            PMID: 32233789
  Bacterial load and defective monocyte-derived macrophage bacterial phagocytosis in biomass smoke-related COPD.

    Ghosh B, Gaike AH, Pyasi K, Brashier B, Das VV, Londhe JD, Juvekar S, Shouche YS, Donnelly LE, Salvi SS, Barnes PJ
        

                    Eur Respir J.
        
                    2019 Feb;
        
                    53(2).
        
                    pii: 1702273. doi: 10.1183/13993003.02273-2017
                            PMID: 30578387 
          Education
              
            **Symbiosis International (Deemed University), Pune, India**
Ph.D., Health and Biological Science (2018)

**Aston University, Birmingham, United Kingdom**
M.Sc., Biomedical Sciences (2012)

**St. Joseph’s University, Bangalore, India**
B.Sc., Microbiology, Chemistry and Zoology (2010)             
                        Experience
              
            **Research Fellow**
National Institute of Health (National Institute of Arthritis and Musculoskeletal and Skin Diseases), Bethesda, MD (2023 – Current)

**Postdoctoral Fellow**
Johns Hopkins University (Johns Hopkins Bloomberg School of Public Health), Baltimore, MD (2018 – 2023)

**Research Advisor**
Nightingales Medical Trust, Bangalore, India (2017 – 2018)

**Research Fellow**
Chest Research Foundation, Pune, India (2014 – 2017)

**Junior Research Fellow (Teaching Assistant)**
Symbiosis International (Deemed University) – Symbiosis Institute of Health Sciences, Pune, India (2013 – 2014)


Last Updated: August 2023


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