An official website of the United States government
          Here’s how you know
        Here’s how you know**Official websites use .gov**A
              **.gov** website belongs to an official government
              organization in the United States.
        **Secure .gov websites use HTTPS**A
              **lock** (
              Locked padlock icon) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
 Top Utility Nav
        
        
        Asian-Language Resources
        
        Portal en español


Site search Mega Menu
  

        

        Home
                  Health Topics
                                      
    
  Health Topics

    Arthritis and Rheumatic Diseases
          
    Muscle and Bone Diseases
          
    Skin Diseases
          
    All Diseases and Conditions
          
    Publication Catalog
                  Grants & Funding
                                      
    
  Grants & Funding

    Current Funding Opportunities
          
    Supported Scientific Programs
          
    NIAMS-Supported Programs
          
    Applying for a Grant
          
    NIH Policies and Guidance
          
    Peer Review and Grants Administration Resources
          
    Types of Funding Mechanisms (Activity Codes)
                  Labs @ NIAMS
                                      
    
  Labs @ NIAMS

    NIAMS Labs and Core Facilities
          
    Research Faculty
          
    Research Areas
          
    NIAMS Scientific Advances
          
    Training and Career Development
                  Clinical Trials
                                      
    
  Clinical Trials
      
            For Principal Investigators

    Clinical Trial Policies, Guidelines, and Templates
          
    Conducting Clinical Trials
          
    Register with ClinicalTrials.gov

For Patients

What is a Clinical Trial?
	Clinical Trials at NIAMS
	Clinical Trials in the Spotlight
                  News & Events
                                      
    
  Newsroom

    All NIAMS News
          
    NIAMS Newsletters
          
    Meetings & Events
                  About NIAMS
                                      
    
  About NIAMS

    Director's Page
          
    NIAMS Organization
          
    Strategic Plan Fiscal Years 2020-2024
          
    Staff Directory
          
    NIAMS Budget
          
    Partnerships
          
    Contact NIAMS
                  Community Outreach
                                      
    
  Community Outreach

    Bone Health
          
    Joint Health
          
    Muscle, Tendon, and Ligament Health
          
    Skin Health
          
    Health Information For Kids And Young Adults
          
    Health Information For Older Adults/Seniors
          
    Printable Materials for Community Events
          
    Resources in Other Languages
          
    Annual Health Observances
          
    Social Media Resources Breadcrumb
    Home
          About NIAMS
          Yosuke Kunishita, M.D., Ph.D.





Yosuke Kunishita, M.D., Ph.D.


Postdoctoral Visiting Fellow
    Scleroderma Genomics and Health Disparities Unit Image
              Headshot of a man wearing glasses in front of a scientific poster. 
            Contact Information

                                                  301-402-6776
                
                                                10 Center Drive
                  
            Building 10, Room 13C217
      
                  
                                   Bethesda MD 20892
                
                                                yosuke.kunishita@nih.gov 
                Summary
          Yosuke Kunishita, M.D., Ph.D., was awarded his medical degree in March 2011 from Asahikawa Medical University, Asahikawa, Japan. He started working as an adult rheumatologist at Yokohama City University, Yokohama, Japan in 2013. During his clinical work, Dr. Kunishita learned that the causes and pathophysiology of many autoimmune and inflammatory diseases still need to be established. His desire to understand more about immunology led him to graduate school in 2015.In graduate school, Dr. Kunishita researched the dysfunction of TRIM21 in systemic lupus erythematosus (SLE) using mouse models and human specimens. He received his Ph.D. in Medical Science from Yokohama City University Graduate School of Medicine, Yokohama, Japan in 2020. Before coming to the NIH, he conducted several research studies using clinical data, human specimens, and cell lines, focusing on rheumatoid arthritis, SLE, and VEXAS syndrome.In 2023, he came to the NIH as a postdoctoral visiting fellow to work with Dr. Daniel L. Kastner in the Inflammatory Disease Section, NHGRI, NIH, and Dr. Pravitt Gourh in the Scleroderma Genomics and Health Disparities Unit, NIAMS, NIH.
        
                  Research Statement
          
            The goal of Dr. Kunishita's research project aims to search for novel pathogenic germline and somatic mutations in adult-onset inflammatory disease to elucidate the pathogenesis, search for therapeutic targets, and develop therapies. 

            Scientific Publications
              Efficacy and safety of abatacept in patients with rheumatoid arthritis with previous malignancy.

    Kunishita Y, Ichikawa K, Uzawa Y, Mitsuhashi M, Yoshioka Y, Okubo T, Nagaoka S
        

                    Ther Adv Musculoskelet Dis.
        
                    2023;
        
                    15().
        
                    doi: 10.1177/1759720X231186874
                            PMID: 37539016
  Case Report: Tocilizumab Treatment for VEXAS Syndrome With Relapsing Polychondritis: A Single-Center, 1-Year Longitudinal Observational Study In Japan.

    Kunishita Y, Kirino Y, Tsuchida N, Maeda A, Sato Y, Takase-Minegishi K, Yoshimi R, Nakajima H
        

                    Front Immunol.
        
                    2022;
        
                    13().
        
                    doi: 10.3389/fimmu.2022.901063
                            PMID: 35769485
  Anti-TRIM21 antibody is associated with aberrant B-cell function and type I interferon production in systemic lupus erythematosus.

    Kunishita Y, Yoshimi R, Kamiyama R, Kishimoto D, Komiya T, Sakurai N, Sugiyama Y, Takase-Minegishi K, Kirino Y, Nagaoka S, Nakajima H
        

                    Lupus.
        
                    2021 Nov;
        
                    30(13).
        
                    doi: 10.1177/09612033211042293
                            PMID: 34565210
  Pathogenic UBA1 variants associated with VEXAS syndrome in Japanese patients with relapsing polychondritis.

    Tsuchida N, Kunishita Y, Uchiyama Y, Kirino Y, Enaka M, Yamaguchi Y, Taguri M, Yamanaka S, Takase-Minegishi K, Yoshimi R, Fujii S, Nakajima H, Matsumoto N
        

                    Ann Rheum Dis.
        
                    2021 Aug;
        
                    80(8).
        
                    doi: 10.1136/annrheumdis-2021-220089
                            PMID: 33789873
  TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis.

    Kunishita Y, Yoshimi R, Kamiyama R, Kishimoto D, Yoshida K, Hashimoto E, Komiya T, Sakurai N, Sugiyama Y, Kirino Y, Ozato K, Nakajima H
        

                    Front Immunol.
        
                    2020;
        
                    11().
        
                    doi: 10.3389/fimmu.2020.00098
                            PMID: 32117252
  Non-IgG4-related Multifocal Fibrosclerosis.

    Kunishita Y, Yoshimi R, Takeno M, Yamanaka S, Sugiyama Y, Tsuchida N, Kishimoto D, Kamiyama R, Minegishi K, Hama M, Kirino Y, Ishigatsubo Y, Ueda A, Nakajima H
        

                    Intern Med.
        
                    2016;
        
                    55(17).
        
                    doi: 10.2169/internalmedicine.55.6297
                            PMID: 27580557 
          Education
              
            **Yokohama City University Graduate School of Medicine, Yokohama, Japan**Ph.D. in Medical Science (2015-2020)**Asahikawa Medical University, Asahikawa, Japan** M.D. (2005-2011)             
                        Experience
              
            **Postdoctoral Visiting Fellow** Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health (August 2023-present)**Visiting Researcher**Yokohama City University Graduate School of Medicine, Yokohama, Japan (April 2020-present)**Chief Physician**Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan (April 2020-July 2023)


Last Updated: March 2024


Back to Top
 About NIAMS
                    Clinical Trials
                    Grants & Funding
                    Health Topics
                    Labs @ NIAMS
              News Room
                    NIAMS Multimedia Library
                    Disclaimer
                    FOIA
                    Contact us
              Privacy Statement
                    Accessibility
                    HHS Vulnerability Disclosure
                    Social Media Moderation Policy
                    NIAMS Archives
        Subscribe to Our E-Newsletters
            Click the button to see different options to sign up for newsletters.
            Click Here to Subscribe
          Follow us on
  
  About NIH
                  Accessibility Support
            FOIA requests
                  No FEAR Act data
            Office of the Inspector General
                  Performance reports
            Privacy Policy