## Contact Information

Bethesda MD20892

sartorev@mail.nih.gov

## Media Resources

vittorio_sartorelli_photo.jpg

## Summary

Dr. Vittorio Sartorelli received his M.D. from the University of Brescia, Italy and completed a residency in oncology at the University of Milan, Italy. He joined the Genetics Department and the Department of Medicine of the Stanford University for his postdoctoral education. In 1993, he joined the Department of Biochemistry and Molecular Biology of the Keck School of Medicine, University of Southern California as an Assistant Professor. In 1999, he was recruited to head the Muscle Gene Expression Group within the Laboratory of Muscle Biology of the Intramural Program at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) within the National Institutes of Health. He is currently the Chief of the Laboratory of Muscle Stem Cells & Gene Regulation and the NIAMS Deputy Scientific Director.

## Research Statement

The Laboratory of Muscle Stem Cells & Gene Regulation focuses on the cellular and molecular mechanisms regulating specification, differentiation, and regeneration of skeletal muscle cells. The objective is to provide a conceptual and practical framework contributing to the diagnosis and treatment of human diseases affecting skeletal muscles. Specific areas of investigation are: 1) transcriptional control of the regulatory circuitries involved in different aspects of adult muscle stem cell biology, 2) functional relation of metabolites and epigenetic modifications impacting adult muscle stem cell biology, 3) role of non-coding RNAs in skeletal muscle biology.

## Scientific Publications

###             Integrating single-cell transcriptomes, chromatin accessibility, and multiomics analysis of mesoderm-induced embryonic stem cells.        

4(2).

###             Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling.        

58(12).

###             Transcriptomics, regulatory syntax, and enhancer identification in mesoderm-induced ESCs at single-cell resolution.        

40(7).

###             Protocol for RNA-seq library preparation starting from a rare muscle stem cell population or a limited number of mouse embryonic stem cells.        

2(2).

###             Enhancers, gene regulation, and genome organization.        

35(7-8).

###             FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age.        

22(11).

###             Enhancer RNAs are an important regulatory layer of the epigenome.        

27(6).

###             Single cell analysis of adult mouse skeletal muscle stem cells in homeostatic and regenerative conditions.        

146(12).

###             A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans.        

71(1).

###             Shaping Gene Expression by Landscaping Chromatin Architecture: Lessons from a Master.        

71(3).

###             The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins.        

68(2).

###             Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells.        

17(5).

###             The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1.        

14(5).

###             Metabolic Reprogramming of Stem Cell Epigenetics.        

17(6).

###             The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells.        

16(2).

###             eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci.        

51(5).

###             Polycomb protein Ezh1 promotes RNA polymerase II elongation.        

45(2).

## Education

**University of Brescia, Italy**M.D.

**University of Milan, Italy**Specialty in Oncology

## Experience

**Deputy Scientific Director**NIAMS, NIH

**Chief**Laboratory of Muscle Stem Cells & Gene Regulation, NIAMS, NIH

**Group Leader**Laboratory of Muscle Biology, NIAMS, NIH

**Postdoctoral Fellow**Stanford University

**Assistant Professor**Department of Biochemistry and Molecular BiologyUniversity of Southern California, Los Angeles

June 2023

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