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		Search Text: Home/< Back ToThe Science/Epithelial Systems Biology
  Epithelial Systems Biology
    Research in the Epithelial Systems Biology Laboratory, led by Dr. Mark A. Knepper, concentrates on the physiology and pathophysiology of the kidney, with particular focus on regulation of water and salt transport by the peptide hormone vasopressin.
    On This Page
    
          knepper
  Mark Knepper, M.D., Ph.D.
          Senior Investigator
          Email
      Meet the Team
            Contact us
  Senior Investigator Research Interests
            
  Research Interests
              **The Epithelial Systems Biology Laboratory**, headed by Mark Knepper, uses *systems biology*-based approaches to study how the kidney regulates water excretion. This involves use of large-scale data acquisition techniques, such as protein mass spectrometry and ‘next-generation’ DNA sequencing technologies to discover molecular mechanisms involved in renal water transport. Much of the focus is on regulation of molecular water channels (*aquaporins*) by the hormone *vasopressin* in renal collecting duct epithelial cells. The **Epithelial Systems Biology Laboratory** is a small close-knit group of scientists devoted to development and exploitation of cutting-edge experimental and computational tools for these studies.

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  Featured Publications
                A Comprehensive Map of mRNAs and Their Isoforms across All 14 Renal Tubule Segments of Mouse.
            Authors:Chen L, Chou CL, Knepper MA.
                                                                                                                        
            J Am Soc Nephrol.
      
                2021 Mar 04;32(4):897-912
        Read Publication
                      Targeted Single-Cell RNA-seq Identifies Minority Cell Types of Kidney Distal Nephron.
            Authors:Chen L, Chou CL, Knepper MA.
                                                                                                                        
            J Am Soc Nephrol.
      
                2021 Mar 04;32(4):886-896
        Read Publication
                      Phosphoproteomic identification of vasopressin-regulated protein kinases in collecting duct cells.
            Authors:Datta A, Yang CR, Salhadar K, Park E, Chou CL, Raghuram V, Knepper MA.
                                                                                                                        
            Br J Pharmacol.
      
                2021 Mar 01;178(6):1426-1444
        Read Publication
                      NGS-Integrator: An efficient tool for combining multiple NGS data tracks using minimum Bayes' factors.
            Authors:Wen B, Jung HJ, Chen L, Saeed F, Knepper MA.
                                                                                                                        
            BMC Genomics
      
                2020 Nov 19;21(1):806
        Read Publication
                      Transcriptomes of Major Proximal Tubule Cell Culture Models.
            Authors:Khundmiri SJ, Chen L, Lederer ED, Yang CR, Knepper MA.
                                                                                                                        
            J Am Soc Nephrol.
      
                2021 Jan 01;32(1):86-97
        Read Publication
                                View More Publications
  Meet the Team

    knepper

            Mark Knepper, M.D., Ph.D.
                Senior Investigator
                Mark Knepper received a B.S. in chemical engineering from the University of Michigan, a Ph.D. in biomedical engineering, and a M.D. from Case Western Reserve University (CWRU), and has an honorary Ph.D. from the University of Aarhus in Denmark. He has been a NIH scientist since 1978 and is currently head of the Epithelial Systems Biology Laboratory at the NHLBI. Dr. Knepper has received the H.W. Smith Award (the highest award of the American Society of Nephrology), the R.W. Berliner Award at Yale University, the C.W. Gottschalk Award of the American Physiological Society, the Hugh Davson Lectureship of the American Physiological Society, and the D.W. Seldin Lectureship of the American Heart Association (Council on the Kidney in Cardiovascular Disease). He has published over 400 peer-reviewed papers on renal physiology, hypertension, nephrology, and systems biology. His editorial positions have spanned the American Journal of Physiology, and the Journal of Clinical Investigation. Dr. Knepper is a member of the American Heart Association, American Physiological Society, American Association for the Advancement of Science, American Society of Nephrology, and Biomedical Engineering Society.
    
          Contact the lab
    10 Center DrBethesda, MD 20814United States
        Phone:
                    301-496-3064
                Fax:
  Chou
    
            Joe Chou, Ph.D.
        

    Staff Scientist

        cc17w@nih.gov
            Raghuram
    
            Viswanathan Raghuram, Ph.D.
        

    

        viswanathan.raghuram@nih.gov
            photo of Chin-Rang Yang
    
            Chin-Rang Yang, Ph.D.
        

    Staff Scientist

        yangc3@mail.nih.gov
            Chen
    
            Lihe Chen, Ph.D.
        

    Research Fellow

        lihe.chen@nih.gov
            Park
    
            Euijung  Park, PhD
        

    Visiting Fellow
            avatar
    
            Hiroaki  Kikuchi, MD, PhD
        

    Visiting Postdoctoral Fellow
            Khan
    
            Brian  Poll, Ph.D
        

    Postdoctoral Fellow
            Leo
    
            Kirby Leo, Ph.D.
        

    Postdoctoral Fellow
            Mehta
    
            Yash Mehta
        

    Postbaccalaureate Fellow
            Lewis
    
            Spencer  Lewis
        

    Postbaccalaureate Fellow
            photo of Trairak Pisitkun
    
            Trairak Pisitkun, M.D.
        

    Special Volunteer

        pisitkut@mail.nih.gov
            Shaza Khan
    
            Shaza  Khan
        

    Special Volunteer
            avatar
    
            Syed Jalal  Khundmiri, Ph.D.
        

    Special Volunteer
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