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          About NIAMS
          McKella Sylvester, B.A.





McKella Sylvester, B.A.


Postbaccalaureate Fellow
    Vasculitis Translational Research Program Image
              Headshot of a young woman with long dark hair 
            Contact Information

                                
                                                10 Center Drive
                  
            Building 10, Room 12S428
      
                  
                                   Bethesda MD 20892
                
                                                mckella.sylvester@nih.gov 
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                headshot-mckella-sylvester.jpg 
                Summary
          McKella Sylvester graduated cum laude from Colgate University in 2021 with a B.A. in English literature and a minor in chemistry. Her undergraduate experience involved the organic synthesis of Tn antigen mimics for oncological studies. Before joining NIAMS, McKella was a postbaccalaureate fellow in Dr. Daniella Schwartz’s lab at NIAID, where she modeled T-helper-9 pathogenicity in psoriatic cardiovascular disease using animal models.

Currently, McKella is a postbaccalaureate fellow in the Vasculitis Translational Research Program at NIAMS, where she examines the immune profiles of patients with vasculitis using ex-vivo assays and flow cytometry.
        
                  Research Statement
          
            McKella’s research focuses on T-helper-17 pathology in interleukin-6 mediated Giant Cell Arteritis (GCA), a vasculitis that affects large blood vessels. 

            Scientific Publications
              Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of T(H)9 cells to promote allergic inflammation.

    Son A, Meylan F, Gomez-Rodriguez J, Kaul Z, Sylvester M, Falduto GH, Vazquez E, Haque T, Kitakule MM, Wang C, Manthiram K, Qi CF, Cheng J, Gurram RK, Zhu J, Schwartzberg P, Milner JD, Frischmeyer-Guerrerio PA, Schwartz DM
        

                    Nat Immunol.
        
                    2023 Jun;
        
                    24(6).
        
                    doi: 10.1038/s41590-023-01501-5
                            PMID: 37106040
  Deep immune profiling uncovers novel associations with clinical phenotypes of multisystem inflammatory syndrome in children (MIS-C).

    Redmond CJ, Kitakule MM, Son A, Sylvester M, Sacco K, Delmonte O, Licciardi F, Castagnoli R, Poli MC, Espinoza Y, Astudillo C, Weber SE, Montealegre Sanchez GA, Barron KS, Magliocco M, Dobbs K, Zhang Y, Matthews H, Oguz C, Su HC, Notarangelo LD, Frischmeyer-Guerrerio P, Schwartz DM
        

                    Ann Rheum Dis.
        
                    2023 Mar;
        
                    82(3).
        
                    doi: 10.1136/ard-2022-223269
                            PMID: 36424123
  PET/CT-Based Characterization of 18F-FDG Uptake in Various Tissues Reveals Novel Potential Contributions to Coronary Artery Disease in Psoriatic Arthritis.

    Schwartz DM, Parel P, Li H, Sorokin AV, Berg AR, Chen M, Dey A, Hong CG, Playford M, Sylvester M, Teague H, Siegel E, Mehta NN
        

                    Front Immunol.
        
                    2022;
        
                    13().
        
                    doi: 10.3389/fimmu.2022.909760
                            PMID: 35720288
  The Interactions Between Autoinflammation and Type 2 Immunity: From Mechanistic Studies to Epidemiologic Associations.

    Sylvester M, Son A, Schwartz DM
        

                    Front Immunol.
        
                    2022;
        
                    13().
        
                    doi: 10.3389/fimmu.2022.818039
                            PMID: 35281022 
          Education
              
            **Colgate University**
B.A., English with minor in Chemistry (2021)             
                        Experience
              
            **NIH IRTA Postbaccalaureate Fellowship**
National Institute of Allergy and Infectious Diseases, Food Allergy Lab Section Bethesda, MD (2021-2022)


Last Updated: July 2023


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