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          About NIAMS
          Amy Coxon, Ph.D.





Amy Coxon, Ph.D.


Biologist
    Lab Manager, Cutaneous Development and Carcinogenesis Section Profile Image 
            Contact Information

                                                  301-480-7252
                
                                                10 Center Drive
                  
            Building 10, Room 12S239
      
                  
                                   Bethesda MD 20892
                
                                                coxona@mail.nih.gov 
                Summary
          Dr. Amy Coxon is a biologist and lab manager for the Brownell Lab. She has received awards for her research including the American Association for Cancer Research (AACR)-AFLAC Young Investigators Award and the American Association for Cancer Research-Pharmingen Young Investigators Awards. She has presented at meetings such as the AACR Mouse Models of Cancer Meeting, the AACR meetings, and the Oncogenes and Tumors Suppressor meetings.  In addition, she received an NIH Office of the Director Honor Award for her work in transferring critical cell lines to a National Cancer Institute cell line repository.
        
                  Research Statement
          
            Dr. Coxon worked on lung cancer, developed a model for medullary thyroid cancer that mimicked human MEN2A mutations, and studied a translocation involved in the development of salivary gland cancer, before coming to work in the Brownell Lab.  In the Brownell Lab, she is involved in the study of merkel cell carcinoma (MCC), a rare and aggressive skin cancer. She also investigates the Merkel cell polyomavirus that drives MCC. Dr. Coxon applies her expertise in molecular biology, mouse genetics, and xenograft models to investigate the pathobiology of MCC with the goal of identifying novel therapeutic targets. 

            Scientific Publications
              Hedgehog Signaling Inhibitors Fail to Reduce Merkel Cell Carcinoma Viability.

    Carroll TM, Williams JS, Daily K, Rogers T, Gelb T, Coxon A, Wang SQ, Crago AM, Busam KJ, Brownell I
        

                    J Invest Dermatol.
        
                    2017 May;
        
                    137(5).
        
                    doi: 10.1016/j.jid.2017.01.008
                            PMID: 28130073
  Assessment of cancer cell line representativeness using microarrays for Merkel cell carcinoma.

    Daily K, Coxon A, Williams JS, Lee CR, Coit DG, Busam KJ, Brownell I
        

                    J Invest Dermatol.
        
                    2015 Apr;
        
                    135(4).
        
                    doi: 10.1038/jid.2014.518
                            PMID: 25521454
  Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer.

    Komiya T, Coxon A, Park Y, Chen WD, Zajac-Kaye M, Meltzer P, Karpova T, Kaye FJ
        

                    Oncogene.
        
                    2010 Mar 18;
        
                    29(11).
        
                    doi: 10.1038/onc.2009.453
                            PMID: 20010869
  Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes.

    Coxon A, Rozenblum E, Park YS, Joshi N, Tsurutani J, Dennis PA, Kirsch IR, Kaye FJ
        

                    Cancer Res.
        
                    2005 Aug 15;
        
                    65(16).
  t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.

    Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ
        

                    Nat Genet.
        
                    2003 Feb;
        
                    33(2).
  Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

    Modi S, Kubo A, Oie H, Coxon AB, Rehmatulla A, Kaye FJ
        

                    Oncogene.
        
                    2000 Sep 21;
        
                    19(40). 
          Education
              
            **George Washington University**Ph.D., Genetics, 2000 **Liberty University**B.S., Biology, 1991             
                        Experience
              
            **Biologist**Brownell Lab, NIAMS, NIH **Professorial Lecturer, Genetics**George Washington University **Faculty, Genetics**Foundation for Advanced Education in the Sciences **Part-time Faculty, Bioethics**Trinity International University Summer Pre-med Institute


Last Updated: March 2024


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