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<article class="node node--type-science node--science-theme--blue node--view-mode-full">

  
    

  
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      <div class="responsive-container responsive-container-constrained breadcrumbs-container"><div class="breadcrumbs"><ul> <li class='breadcrumb-home'><a href='/'>Home</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-parent'><a href='/node/80002'><span class='back-to'> < Back To </span>The Science</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-current'>Murine Phenotyping Core</li></ul></div></div>
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      <h1>Murine Phenotyping Core</h1>
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            <div class="field field--name-field-component-lab-banner-descr field--type-text-long field--label-hidden field__item"><p>The NHLBI Murine Phenotyping Core carries out physiologic and behavioral testing in a diversity of mouse models for NHLBI and other NIH institutes.</p>
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<span>Danielle Springer, M.D., V.M.D., D.A.C.L.A.M.</span>

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            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Core Director</div>
      
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<h2 class="field--name-field-component-section-titl component-section-section-title">Research</h2>

            <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden clearfix field__item"><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>The NHLBI Murine Phenotyping Core carries out physiologic and behavioral testing in a diversity of mouse models for NHLBI and other NIH institutes.</p><p><strong>Testing Areas include the following:</strong></p><ul><li>Cardiovascular Phenotyping</li><li>Metabolic Phenotyping</li><li>Pulmonary Phenotyping</li><li>Neuromuscular Phenotyping</li><li>Behavioral Phenotyping</li><li>Exercise Physiology</li><li>Advanced Imaging Modalities (whole body high frequency ultrasound imaging, vascular imaging, faxitron x-ray, and CT (coming soon))</li></ul></div></div></div></div>
      
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Investigation and identification of etiologies involved in the development of acquired hydronephrosis in aged laboratory mice with the use of high-frequency ultrasound imaging.</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Springer DA, Allen M, Hoffman V, Brinster L, Starost MF, Bryant M, Eckhaus M
            </div>
                                                                
            <span>
            Pathobiol Aging Age Relat Dis
      
                2016 Aug 01</span>;4
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                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/25143818" aria-label="Investigation and identification of etiologies involved in the development of acquired hydronephrosis in aged laboratory mice with the use of high-frequency ultrasound imaging." class="read-publications">Read Publication</a>
                            
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            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Low ambient oxygen prevents atherosclerosis.</div>
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               <span>Authors: </span>Kang JG, Sung HJ, Amar MJ, Pryor M, Remaley AT, Allen MD, Noguchi AC, Springer DA, Kwon J, Chen J, Park JH, Wang PY, Hwang PM
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            <span>
            J Mol Med (Berl)
      
                2016 Mar 01</span>;94(3):277-86
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                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/26830628" aria-label="Low ambient oxygen prevents atherosclerosis." class="read-publications">Read Publication</a>
                            
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Mice expressing reduced levels of hepatic glucose-6-phosphatase-α activity do not develop age-related insulin resistance or obesity.</div>
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            <div class="publicationAuthors">
               <span>Authors: </span>Kim GY, Lee YM, Cho JH, Pan CJ, Jun HS, Springer DA, Mansfield BC, Chou JY
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            <span>
            Hum Mol Genet
      
                2015 Sep 15</span>;24(18):5115-25
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                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/26089201" aria-label="Mice expressing reduced levels of hepatic glucose-6-phosphatase-α activity do not develop age-related insulin resistance or obesity." class="read-publications">Read Publication</a>
                            
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter.</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Holmström KM, Pan X, Liu JC, Menazza S, Liu J, Nguyen TT, Pan H, Parks RJ, Anderson S, Noguchi A, Springer D, Murphy E, Finkel T
            </div>
                                                                                            
            <span>
            J Mol Cell Cardiol
      
                2015 Aug 01</span>;85:178-82
        </div>
        <div class="flex-item">
                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/26057074" aria-label="Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter." class="read-publications">Read Publication</a>
                            
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise.</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Tiano JP, Springer DA, Rane SG
            </div>
                                                                                                                        
            <span>
            J Biol Chem
      
                2015 Mar 20</span>;290(12):7671-84
        </div>
        <div class="flex-item">
                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/25648888" aria-label="SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise." class="read-publications">Read Publication</a>
                            
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<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="250" height="250" alt="generic avatar" data-src="/sites/default/files/styles/square_image_250x250/public/2017-12/genericavatar_78.png?itok=U0e6m-gm" class="b-lazy image-style-square-image-250x250" />


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                    Danielle Springer, M.D., V.M.D., D.A.C.L.A.M.
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            <div class="clearfix text-formatted field field--name-field-person-bio field--type-text-with-summary field--label-hidden field__item"><p><span>Danielle Springer, V.M.D., D.A.C.L.A.M., is the director of the Murine Phenotyping Core Facility at the NHLBI.</span></p>
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