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          Grants & Funding: The NIAMS Extramural Program
          Musculoskeletal Tissue Engineering and Regenerative Medicine Program








Musculoskeletal Tissue Engineering and Regenerative Medicine Program FacebookEmailPrintFacebookEmail
        Musculoskeletal

        Overview
              
            This program supports basic and translational research in the repair, regeneration, and restoration of function of injured and/or diseased musculoskeletal tissues using stem cell biology and engineering-based approaches. These tissues include bone, cartilage, tendon, ligament, menisci, muscle and intervertebral discs. Multi- and inter- disciplinary research teams with expertise in biological and physical sciences and cross-training for emerging scientists are encouraged.Areas of supported research include the following:UnderstandingPathways of human organogenesis - how cells self-assemble into complex tissues *in vitro* and *in vivo*.Cellular processes of mammalian stem and progenitor cells - controlling survival, differentiation, proliferation, migration, senescence, and responses to stimuli.Role of inflammation and responses to immune signals.EngineeringSmart scaffolds for structural, mechanical, and functional support.Micro environment to promote repair and regeneration.Developing effective strategies toRecruit and direct endogenous progenitor or stem cells.Integrate engineered tissues with the host while reducing adverse effects (e.g., immunogenicity, toxicity).Improve molecular, cellular, or gene-based therapies.Building tools forCell optimization and scale-up.3-D fabrication.Tissue preservation and storage.Real-time, non-invasive modalities to track cells, and/or monitor tissue-function repair and integration process *in vivo*.Establish models, such as:3-D human tissue models for drug screening or studying pathophysiological processes.Preclinical models to promote direct clinical translation.Exploring cross-talk between regeneration and rehabilitation to restore functions.Contact UsAron Marquitz, Ph.D.Program Director6701 Democracy BoulevardBuilding: Democracy 1, Suite 800BethesdaMD20892-4872aron.marquitz@nih.gov301-435-1240

                        
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        Last Updated: April 2024
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