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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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      How Clinical Trials Work
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Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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          Disease or Condition
        
          CLEARAcute Respiratory Distress SyndromeAlpha-1 Antitrypsin DeficiencyAnemiaAngina (Chest Pain)Aortic AneurysmAplastic AnemiaArrhythmiasAsthmaAtherosclerosisAtrial FibrillationBleeding DisordersBlood CholesterolBlood Clotting DisordersBronchiectasisBronchitisCardiac ArrestCardiac CatheterizationCardiogenic ShockCardiomyopathyChildhood ObesityCircadian Rhythm DisordersConduction DisordersCongenital Heart DefectsCOPDCoronary Artery Bypass GraftingCoronary Heart DiseaseCystic FibrosisDeep Vein Thrombosis (DVT)DefibrillatorsGet Regular Physical ActivityHeart-Healthy LivingHeart AttackHeart FailureHeart InflammationHeart SurgeryHeart TestsHeart TransplantHeart TreatmentsHeart Valve DiseasesHemolytic AnemiaHigh Blood PressureHigh Blood TriglyceridesHow Sleep WorksHow the Heart WorksHow the Lungs WorkIdiopathic Pulmonary FibrosisInsomniaInterstitial Lung DiseasesLAMLong QT SyndromeLow Blood PressureLung Disease TreatmentsMarfan SyndromeMetabolic SyndromeNarcolepsyNewborn Breathing ConditionsOverweight and ObesityPacemakersPeripheral Artery DiseasePlatelet DisordersPleural DisordersPneumoniaPolycythemia VeraPrimary Ciliary DyskinesiaPulmonary HypertensionPulmonary RehabilitationRespiratory FailureSarcoidosisSickle Cell Disease(-)
Sleep ApneaSleep Deprivation and DeficiencySleep StudiesSmoking and Your HeartStrokeTests for Lung DiseaseThalassemiaThe LungsTranscatheter Aortic Valve Replacement (TAVR)Treatments for Blood DisordersVasculitisVenous ThromboembolismVentilator/Ventilator SupportWhat Is Physical Activity?Women and Heart Disease

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Clear AllSleep Apnea
Showing 1 - 10 out of 11 results
      
      Assessment of Continuous Positive Airway Pressure Therapy in IPF
      Recruiting
                          New York
        The purpose of this study is to evaluate whether biomarkers of lung injury and remodeling are responsive to effective continuous positive airway pressure (CPAP) treatment in adults with idiopathic pulmonary fibrosis (IPF) and moderate-to-severe obstructive sleep apnea (OSA).
      Idiopathic Pulmonary Fibrosis
              Sleep Apnea
                          Adult, Older Adult
    Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
      Recruiting
                          Michigan
        This research study is designed to learn, first, whether two anesthetics have different effects on collapse seen within the upper airway during sleep endoscopy.
      Sleep Apnea
                          Child
    Vascular Endothelial Dysfunction in Sleep Apnea
      Recruiting
                          New York
        The purpose of this study is to investigate: 1) whether statins reduce endothelial inflammation and pro-thrombotic conditions in sleep apnea, including in patients adherent to CPAP (Aim 1); and 2) whether statins reduce endothelial inflammation and pro-thrombotic conditions by improving endothelial cholesterol metabolism and trafficking in sleep apnea.
      Sleep Apnea
                          Adult, Older Adult
    Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia
      Recruiting
                          Michigan
        The researchers are investigating if the Self-Supporting Nasopharyngeal Airway (ssNPA) device can be used in the treatment of obstructive sleep apnea in children with Hypotonic Upper Airway Obstruction (HUAO).
      Sleep Apnea
                          Child, Adult
    Assessment of Continuous Positive Airway Pressure Therapy in IPF
      Recruiting
                          New York
        The purpose of this study is to evaluate whether biomarkers of lung injury and remodeling are responsive to effective continuous positive airway pressure (CPAP) treatment in adults with idiopathic pulmonary fibrosis (IPF) and moderate-to-severe obstructive sleep apnea (OSA).
      Interstitial Lung Diseases
              Sleep Apnea
                          Adult, Older Adult
    A Study of Myofunctional Water Bottle to Reduce Snoring
      Recruiting
                          Minnesota
        This research study is being done to determine whether the repetition and resistance from the daily use of the myofunctional therapy (MT) nozzle will improve obstructive sleep apnea and primary snoring.
      Sleep Apnea
                          Adult, Older Adult
    Patient-centered and Neurocognitive Outcomes With Acetazolamide for Sleep Apnea
      Recruiting
                          California
        The goal of this study is to test if acetazolamide can improve sleep apnea, neurocognitive function and quality of life in adults with OSA, and to assess how it does that.
      Sleep Apnea
                          Adult, Older Adult
    Home Apnea Testing in CHildren Trial
      Recruiting
                          Pennsylvania
        This clinical trial will compare home sleep apnea testing with the gold standard in-lab polysomnography in terms of 1) accuracy, 2) therapeutic decision-making, and 3) parent/child acceptability in children referred for evaluation of obstructive sleep apnea.
      Sleep Apnea
                          Child
    Medications for Obstructive Sleep Apnea to Improve Cognition in Children With Down Syndrome
      Recruiting
                          Arizona
        This is an open-label study of the combination of atomoxetine and oxybutynin (ato-oxy) in children with Down syndrome and obstructive sleep apnea (OSA) documented by polysomnography (PSG).
      Sleep Apnea
                          Child
    Managing Opioid Related Sleep Apnea With Acetazolamide
      Recruiting
                          California
        Patients with chronic pain who use opioids appear to be at increased risk for breathing issues during sleep, termed sleep disordered breathing (SDB). Treatment of SDB often consists of use of a device during sleep that provides continuous positive airway pressure (CPAP) via a mask interface. However, this device is not effective or tolerated in all individuals. The goal of this study is to examine whether a medication called acetazolamide can improve SDB, as an alternative to CPAP treatment.
      Sleep Apnea
                          Adult, Older Adult
  
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