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		Search Text: Clinical Trials
					
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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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      How Clinical Trials Work
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      Who Can Participate
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      Benefits, Risks & Safety Measures
Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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          CLEARAcute Respiratory Distress SyndromeAlpha-1 Antitrypsin DeficiencyAnemiaAngina (Chest Pain)Aortic AneurysmAplastic AnemiaArrhythmiasAsthmaAtherosclerosisAtrial FibrillationBleeding DisordersBlood CholesterolBlood Clotting DisordersBronchiectasisBronchitisCardiac ArrestCardiac CatheterizationCardiogenic ShockCardiomyopathyChildhood ObesityCircadian Rhythm DisordersConduction DisordersCongenital Heart DefectsCOPDCoronary Artery Bypass GraftingCoronary Heart DiseaseCystic FibrosisDeep Vein Thrombosis (DVT)DefibrillatorsGet Regular Physical ActivityHeart-Healthy LivingHeart AttackHeart FailureHeart InflammationHeart SurgeryHeart TestsHeart TransplantHeart TreatmentsHeart Valve DiseasesHemolytic AnemiaHigh Blood PressureHigh Blood TriglyceridesHow Sleep WorksHow the Heart WorksHow the Lungs WorkIdiopathic Pulmonary FibrosisInsomniaInterstitial Lung DiseasesLAMLong QT SyndromeLow Blood PressureLung Disease TreatmentsMarfan SyndromeMetabolic SyndromeNarcolepsyNewborn Breathing ConditionsOverweight and ObesityPacemakersPeripheral Artery DiseasePhysical Activity and Your HeartPlatelet DisordersPleural DisordersPneumoniaPolycythemia VeraPrimary Ciliary DyskinesiaPulmonary HypertensionPulmonary RehabilitationRespiratory FailureSarcoidosisSickle Cell DiseaseSleep Apnea(-)
Sleep Deprivation and DeficiencySleep StudiesSmoking and Your HeartStrokeTests for Lung DiseaseThalassemiaThe LungsTranscatheter Aortic Valve Replacement (TAVR)Treatments for Blood DisordersVasculitisVenous ThromboembolismVentilator/Ventilator SupportWhat Is Physical Activity?Women and Heart Disease

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Clear AllSleep Deprivation and Deficiency
Showing 1 - 10 out of 13 results
      
      Role of Sleep Reactivity in Shift Work Disorder
      Recruiting
                          Michigan
        The purpose of this project is to test sleep reactivity as an independent cause of Shift Work Disorder (SWD). The primary hypothesis is that those with high sleep reactivity will show persistent SWD symptoms after experimental reduction of circadian misalignment, which will then be mitigated with CBT.
      How Sleep Works
              Sleep Deprivation and Deficiency
              Sleep Studies
                          Adult, Older Adult
    Dietary Intervention to Mitigate Adverse Consequences of Night Work
      Recruiting
                          Massachusetts
        Shift work increases the risk for diabetes possibly due to the adverse metabolic effects of circadian misalignment. As shift work is not foreseen to disappear, the development of individually-targeted therapies for metabolic health in these vulnerable shift workers is urgently needed. This research will determine whether our dietary intervention can mitigate the adverse metabolic effects of circadian misalignment, which may help in the design of evidence-based dietary interventions to improve the metabolic health in shift workers.
      How Sleep Works
              Sleep Deprivation and Deficiency
              Sleep Studies
                          Adult
                                      Accepting Healthy Volunteers
    The Pregnancy 24/7 Cohort Study
      Recruiting
                          Iowa
              Pennsylvania
              West Virginia
        This study will leverage state-of-the-art, 24-hour behavior assessment in each trimester of pregnancy and examine associations with adverse pregnancy outcomes to inform guidelines and future interventions designed to improve women's pregnancy and long-term cardiovascular health.
      Physical Activity and Your Heart
              Sleep Deprivation and Deficiency
                          Adult
                                      Accepting Healthy Volunteers
                                              Female
    Role of Sleep Reactivity in Shift Work Disorder
      Recruiting
                          Michigan
        The purpose of this project is to test sleep reactivity as an independent cause of Shift Work Disorder (SWD).
      Sleep Deprivation and Deficiency
              Insomnia
                          Adult, Older Adult
    Menstrual-phase-dependent Differences in Response to Sleep Loss
      Recruiting
                          Massachusetts
        This study is designed to assess how healthy premenopausal women respond to different patterns of sleep loss at different times in the menstrual cycle.
      Sleep Deprivation and Deficiency
                          Adult
                                      Accepting Healthy Volunteers
                                              Female
    Dietary Intervention to Mitigate Adverse Consequences of Night Work
      Recruiting
                          Massachusetts
        The goal of this clinical trial is to test whether our dietary intervention can prevent or lessen the negative health effects of night shift work in healthy participants.
      Sleep Deprivation and Deficiency
                          Adult
                                      Accepting Healthy Volunteers
    Rest to Overcome Loss and Reduce Risk
      Recruiting
                          Illinois
        The purpose of this study is to develop and optimize a targeted behavioral intervention for sleep disturbance among individuals who have recently lost a spouse/long-term cohabitating partner.
      Sleep Deprivation and Deficiency
                          Adult, Older Adult
                                      Accepting Healthy Volunteers
    Impact of Yo-Yo Sleep on Cardiometabolic Health
      Recruiting
                          New York
        A large portion of the U.S. adult population reports insufficient sleep on a nightly basis. It has been shown that sustained insufficient sleep leads to adverse cardiometabolic risk profile and positive energy balance. The goal of this clinical trial is to test the impact of repeated intermittent short sleep, with short sleep maintained 5 days per week followed by 2 days of prolonged sleep, compared to daily adequate sleep, on energy balance and cardiometabolic risk.
      Overweight and Obesity
              Sleep Deprivation and Deficiency
                          Adult
                                      Accepting Healthy Volunteers
    Sleep Goal-focused Online Access to Lifestyle Support
      Recruiting
                          Pennsylvania
        The overall goal of the study is to develop a novel weight loss intervention for postpartum people by providing strategies to improve sleep, diet, and physical activity behaviors. In this study, we will recruitment and enroll 40 postpartum people and randomize them to receive the Sleep GOALS intervention or education control to evaluate the intervention's feasibility, acceptability, and preliminary efficacy.
      Sleep Deprivation and Deficiency
                          Adult
                                      Accepting Healthy Volunteers
                                              Female
    Circadian Rhythms and Sleep in Familial Delayed Sleep Phase Syndrome (DSPS) and Advanced Sleep Phase Syndrome (ASPS  )
      Recruiting
                          Illinois
        Are you an adult with a diagnosed sleep phase disorder?
                    This study aims to assess the sleep patterns and quality of sleep in people who have sleep phase disorders to determine how the disorders affect their circadian rhythms. To participate in this study, you must be at least 18 years old and have a sleep phase disorder, such as advanced sleep-wake phase syndrome or delayed sleep-wake phase syndrome. This study is located in Chicago, Illinois.
      Circadian Rhythm Disorders
              Sleep Deprivation and Deficiency
                          Adult, Older Adult
  
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