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		Search Text: Clinical Trials
					
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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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      How Clinical Trials Work
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Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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Showing 1 - 10 out of 56 results
      
      Dietary Intervention to Mitigate Adverse Consequences of Night Work
      Recruiting
                          Massachusetts
        Shift work increases the risk for diabetes possibly due to the adverse metabolic effects of circadian misalignment. As shift work is not foreseen to disappear, the development of individually-targeted therapies for metabolic health in these vulnerable shift workers is urgently needed. This research will determine whether our dietary intervention can mitigate the adverse metabolic effects of circadian misalignment, which may help in the design of evidence-based dietary interventions to improve the metabolic health in shift workers.
      How Sleep Works
              Sleep Deprivation and Deficiency
              Sleep Studies
                          Adult
                                      Accepting Healthy Volunteers
    Survivor mHealth: Wearable Devices in Cancer Survivors
      Recruiting
                          Massachusetts
        Are you a cancer survivor? Would you like to join a clinical trial that is testing whether wearable devices and smartphone apps can help cancer survivors be more active? You must be 18 years old to join. The study is taking place in Worcester, Massachusetts.
      What Is Physical Activity?
              Physical Activity and Your Heart
                          Adult, Older Adult
                                      Accepting Healthy Volunteers
    Zinc Intervention in Elderly for Prevention of Pneumonia
      Recruiting
                          Massachusetts
        Pneumonia is a major public health problem for the elderly and is one of the leading causes of hospitalization and death for this population, particularly for elderly nursing home residents. This planning grants seeks to establish a safe and effective dose of zinc supplementation with the goal to conduct a larger randomized clinical trial to study the effect of zinc supplementation in nursing home elderly with low serum zinc levels on the risk, antibiotic use, and duration of sick days with pneumonia. This project has significant potential to positively impact the health and quality of life in the elderly and to reduce the economic costs associated with their care.
      Pneumonia
              Lung Disease Treatments
                          Older Adult
                                      Accepting Healthy Volunteers
    The BENeFiTS Trial in Beta Thalassemia Intermedia
      Recruiting
                          California
              Massachusetts
              New York
        his trial will evaluate an oral drug discovered in a high throughput screen, which increases fetal globin protein (HbF and red blood cells expressing HbF)and messenger ribonucleic acid (mRNA) to high levels in anemic nonhuman primates and in transgenic mice.
      Sickle Cell Disease
                          Adult, Older Adult
    A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease
      Recruiting
                          Massachusetts
        Sickle Cell Disease (SCD) impairs oxygen transport to tissue and causes endothelial injury. Thus, therapeutic interventions aim to improve both, but there is an unmet need for biomarkers to determine when intervention is necessary and evaluate the effectiveness of the chosen intervention in individual patients. This study proposes to monitor SCD and its treatment through their impact on cerebral hemodynamics, as the brain is one of the most vulnerable and consequential targets of the disease. Specifically, this study will optimize quantitative magnetic resonance imaging (MRI) and advanced optical spectroscopy techniques such as frequency-domain near-infrared and diffuse correlation spectroscopies (FDNIRS-DCS) to monitor 1) cerebral oxygen transport with measures of cerebral blood flow (CBF), cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen consumption (CMRO2) and 2) endothelial function with cerebrovascular reactivity (CVR).
      Sickle Cell Disease
                          Child, Adult
    Molecular Imaging of Primary Amyloid Cardiomyopathy
      Recruiting
                          Massachusetts
        Are you an adult with primary light chain amyloidosis? Researchers in this study are investigating new ways to look at the heart to identify when it is not working properly. You may be able to participate if you are at least 18 years old and have been diagnosed with primary light chain amyloidosis. This study is taking place in Boston, Massachusetts.
      Heart Treatments
                          Adult, Older Adult
    American Lung Association (ALA) Lung Health Cohort
      Recruiting
                          Multiple Locations
        The objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.
      Adult
                                      Accepting Healthy Volunteers
    A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001)
      Recruiting
                          Multiple Locations
        The main goal of this study is to determine whether the treatment will lead to a complete absence of severe vaso-occlusive events (VOEs) in patients with severe SCD.
      Sickle Cell Disease
                          Child, Adult
    Menstrual-phase-dependent Differences in Response to Sleep Loss
      Recruiting
                          Massachusetts
        This study is designed to assess how healthy premenopausal women respond to different patterns of sleep loss at different times in the menstrual cycle.
      Sleep Deprivation and Deficiency
                          Adult
                                      Accepting Healthy Volunteers
                                              Female
    Implementing a Digitally-enabled Community Health Worker Intervention for Patients With Heart Failure
      Recruiting
                          Massachusetts
        Do you have heart failure and live near Massachusetts General Hospital in Boston, Massachusetts? Researchers are testing whether an online program helps lower the number of times patients with heart failure return to the hospital. You may be able to participate if you are at least 18 years old, have heart failure, and live within 30 miles of Massachusetts General Hospital in Boston.
      Heart Failure
                          Adult, Older Adult
                                      Accepting Healthy Volunteers
  
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