U.S. flag

An official website of the United States government

Here’s how you know
Here’s how you know

**Official websites use .gov**
A **.gov** website belongs to an official government organization in the United States.

**Secure .gov websites use HTTPS**
A **lock** ( A locked padlock) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Search Query:
			MAIN MENU

																				
              Health Topics
								All Health Topics A-Z
					
													
		

		Asthma


				

															Heart-Healthy Living


				

															High Blood Pressure


				

															Sickle Cell Disease


				

															Sleep Apnea


				

															Information & Resources on COVID-19
																				
              Health Education
								Education Programs and Initiatives
					
													
		

		The Heart Truth®


				

															Learn More Breathe Better®


				

															Blood Diseases and Disorders Education Program


				

															Publications and Resources
																				
              The Science
								Research Focus Areas
					
													
		

		Blood Disorders and Blood Safety


				

															Sleep Science and Sleep Disorders


				

															Lung Diseases


				

															Health Disparities and Inequities


				

															Heart and Vascular Diseases


				

															Precision Medicine Activities


				

															Obesity, Nutrition, and Physical Activity


				

															Population and Epidemiology Studies


				

															Women’s Health


				

															Research Topics


				

															Clinical Trials


				

															All Science A-Z
																				
              Grants and Training
								Grants and Training Home


				

															Policies and Guidelines


				

															Funding Opportunities and Contacts


				

															Training and Career Development
																				
              News and Events
								News and Events Home
					
													
		

		Email Alerts


				

															All News
					
													
		

		NHLBI News


				

															NHLBI in the Press


				

															Research Features


				

															All Events
					
													
		

		Past Events


				

															Upcoming Events
																				
              About NHLBI
								About NHLBI Home
					
													
		

		Mission and Strategic Vision


				

															Leadership


				

															Divisions, Offices and Centers


				

															Advisory Committees


				

															Budget and Legislative Information


				

															Jobs and Working at the NHLBI


				

															Contact and FAQs


				

															NIH Sleep Research Plan
						
						HOME
		Search Text: Home/< Back ToThe Science/Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures

Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures
                        
                                                Project began
            2016
              Point of contact
            
                
            Laurie Friedman Donze, Ph.D.
                                        On this page
                        At a Glance
                                                                                                                    Why is the project important?
                                                            How does the project contribute to scientific discovery?
                                                            How does the project work?
                                                            More information
        What is the goal of the ADOPT Core Measures Project?
                        
            The long-term goal of the Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures Project is to better understand the well-documented individual differences in response to a wide range of obesity treatments. These differences are likely due to a combination of behavioral, biological, environmental, and psychosocial factors. Yet, we currently lack the data to comprehensively identify the underlying factors and examine how they interact to influence response to treatments.As a first step, the ADOPT Project identified a standard set of about 50 Core Measures, or factors, that can be analyzed across studies to better understand the variation in response to obesity treatments. The ADOPT Project encourages and facilitates the consistent use of these Core Measures in future clinical trials to treat obesity in adults. The goal is to have consistent use and analysis of these Core Measures to create datasets. These datasets can then be used in pooled analyses and meta-analyses to investigate how these Core Measures contribute to individual differences in response to obesity treatments.These analyses can address such questions as:How do psychosocial, environmental, and biological factors affect how well a person adheres to behavioral strategies promoted in obesity intervention trials?How does sleep duration and quality of sleep influence eating patterns and physical activity through circadian rhythms, mood, or both?Does weight loss from restricting calories lead to biological and psychosocial responses that increase the rewarding effects of food?Ultimately, these data can inform the design and delivery of a precision medicine, or a personalized approach to obesity treatment.
                AT A GLANCE
                                        ADOPT provides a framework for how obesity researchers can generate evidence to develop precision medicine approaches to obesity treatment.
          The ADOPT Core Measures Project identified an initial list of Core Measures, or factors, that appear to influence response to obesity treatments.
          Consistent use of the ADOPT Core Measures Project will help us learn how these factors contribute to variable responses to existing obesity treatments.
          The Core Measures span four domains—behavioral, biological, environmental, and psychosocial—and will be updated as the science advances.
          The NHLBI and other NIH Institutes support funding opportunities to add the ADOPT Core Measures Project to current and planned clinical research.
          ADOPT aims to share knowledge across existing obesity research labs and foster collaboration among researchers of varied disciplines and levels of training.
            Why is the ADOPT Core Measures Project important?
    Developing a precision approach to obesity treatment poses significant challenges because treatments that are considered successful are not always effective for everyone, and few factors have been found to reliably predict success. One important reason is that we lack datasets with most or all of the potential factors that can account for the observed differences in response to obesity treatments and that also span the behavioral, biological, environmental, and psychosocial domains. The ADOPT Project is a significant first step toward addressing this challenge.Collection of data on these Core Measures spanning the four interdisciplinary domains should help researchers better describe how the factors work together to impact obesity treatment responses.Learn more about the rationale and process for developing the ADOPT Core Measures Project*.*
              How does the ADOPT Core Measures Project contribute to scientific discovery?
    The ADOPT Core Measures Project provides detailed information on the measures in a publicly available resource, called the Grid-Enabled Measures (GEM). GEM provides researchers access to supporting information on the ADOPT Core Measures Project and facilitates interdisciplinary collaboration across the four ADOPT Project research discipline domains. The resource also serves as a forum for researchers to share their practical experiences with implementing the measures in their clinical trials.The ADOPT Core Measures Project addresses many of the objectives, compelling questions, and critical challenges identified in the 2016 NHLBI Strategic Vision, particularly those related to investigating factors that account for individual differences in health, pathobiology, and responses to treatment.
              How does the ADOPT Core Measures Project work?
    Researchers are encouraged to access and use the Core Measures to help build a database to enable researchers to answer questions about predictors, mediators, and moderators of responses to obesity treatments.The Core Measures are classified into four major domains: behavior, biology, environment, and psychology.View the list of ADOPT Core Measures by domain.
    Behavior
      
	-
		Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures
    Multiple interviewer-administered 24-h recallsHealthy Eating Index-2010EARLY Eating Away from Home QuestionnaireEARLY SSB Consumption QuestionnaireActigraphyGlobal Physical Activity QuestionnairePaffenbarger QuestionnaireMunich Chronotype Questionnaire (MCTQ)Berlin Questionnaire for Sleep ApneaEARLY Self-Weighing Questionnaire
              Biology
      
	-
		Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures
    Height, Weight, and BMI, Waist to Hip Ratio, Waist CircumferenceBioelectrical Impedance Spectroscopy (BIS)Resting (Mifflin-St. Jeor Equation) and Total Energy ExpenditurePhysical Activity Level (PAL)Energy Intake - Steady State & Change Over TimeResting Heart RateAdiponectin, Leptin, AmylinTSH, T4, fT4I (thyroid hormone panel)Ghrelin, GLP1, PYY3-36 (hunger/satiety panel)Metabolite Panel (Glucose, NEFA, TGs)Insulin, Glucagon, HOMA-IR, HOMA-β, HBA1cIL-6, TNF-alpha, CRPWhole Blood
              Environment
      
	-
		Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures
    Home addressWalk Score or EPA WalkabilityNeighborhood Environment Walkability Scale - Land Use Mix Access SubscaleDensity of (1) Supermarkets, (2) Fast food restaurants, and (3) Convenience storesPerceived presence of (1) Supermarkets, (2) Fast Food Restaurants, and (3) Convenience stores, Plus Others (Liese)MESA Neighborhood Healthy Food AvailabilityNeighborhood Deprivation Index (Diez Roux et al)Neighborhood Police-Reported CrimeMESA Perceived Neighborhood SafetyBMI of Spouse/PartnerWeight-related Social Norms ScaleModified Sallis Social Support scalesImportant Others’ Questionnaire
              Psychology
      
	-
		Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures
    Positive and Negative Affect Schedule (state)Perceived Stress ScalePalatable Eating Motives: Coping SubscaleQuestionnaire on Eating and Weight PatternsTrait Food Craving Questionnaire-ReducedReward Based Eating DriveBehavior Rating Inventory of Executive Function-AdultKirby Questionnaire – Delayed Reward DiscountingBehavioral Intention Scale(s)Self-Efficacy Scale(s)‘Liking’ and ‘Wanting’ Visual Analog ScalesHunger and Satiety Visual Analog ScalesMini-International Personality Item Pool (Short form)/Big Five Inventory-2 (Long form)
              More information
    The NHLBI and other NIH Institutes and Centers have released funding opportunity announcements that support the addition of measures to new or existing clinical trials.NOT-21-030: Notice of Special Interest (NOSI): Heart, Lung, Blood and Sleep Focused Ancillary Studies to Large Ongoing Clinical Studies (Revised)For more information on the ADOPT Core Measures Project, contact us at adopt@nih.gov.
                                Related Scientific Focus Areas
                                    Obesity, Nutrition, and Physical Activity
              Precision Medicine Activities
                                                                                                                                                                Related Health Topics
                                    What Are Overweight and Obesity?
              What Is Heart-Healthy Living?
              High Blood Pressure
              What Is Metabolic Syndrome?
              What Is Physical Activity? Back To Top Link
  

        

        Back to top
  Web Policies & Notices
  

        

              Accessibility
                      No FEAR Act Data
                      Privacy Policy
                      Freedom of Information Act (FOIA)
                      HHS Vulnerability Disclosure
    
          Related Government Websites
  

        

              Health and Human Services
                      National Institutes of Health
                      Office of the Inspector General
                      USA.gov
    
          Stay Connected
    
      
            chat bubblesLive ChatLive Chat with us, Monday through Friday, 8:30 a.m. to 5:00 p.m. EST.envelopeGet Email AlertsReceive automatic alerts about NHLBI related news and highlights from across the Institute.
  Footer Bottom
  

        



Contact Us
                            Site Index
                            Jobs