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<article class="node node--type-science node--science-theme--blue node--view-mode-full">

  
    

  
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      <div class="responsive-container responsive-container-constrained breadcrumbs-container"><div class="breadcrumbs"><ul> <li class='breadcrumb-home'><a href='/'>Home</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-parent'><a href='/node/80002'><span class='back-to'> < Back To </span>The Science</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-current'>Sickle Thrombosis and Vascular Biology</li></ul></div></div>
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      <h1>Sickle Thrombosis and Vascular Biology</h1>
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            <div class="field field--name-field-component-lab-banner-descr field--type-text-long field--label-hidden field__item"><p>The Laboratory of Sickle Thrombosis and Vascular Biology, led by Dr. Arun Shet, studies the contribution of inflammation and coagulation to the vascular pathobiology of sickle cell disease.</p>
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<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="shet" data-src="/sites/default/files/styles/square_image/public/2021-07/DSC_0901.jpeg?itok=Sn1PMCwk" class="b-lazy image-style-square-image" />


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<span>Arun Shet, M.D.</span>

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            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Assistant Clinical Investigator </div>
      
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                  <h2 class="component-title">Senior Investigator Research Interests</h2>
            
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    <div class="field__label">Research Interests</div>
              <div class="field__item"><p>Sickle cell disease (SCD) is an inherited gene defect that causes hemoglobin to clump and deform red blood cells, leading to anemia, hemolysis, and vascular occlusions that affect multiple organs. Moreover, sickle shaped red blood cells stick to blood vessel walls thereby slowing or stopping blood flow and the cells lining the blood vessel walls can abnormally express adhesion molecules or proteins that trigger blood coagulation and inflammation in this patients. Dr. Shet’s research aims to better understand the different factors initiating and propagating venous thrombosis in sickle cell disease. To achieve this, <em>in vitro</em> coagulation assays, flow cytometry, and biochemical assays, as well as animal studies (predominantly murine models of SCD) are used to study the mechanisms of coagulation activation and inflammation in SCD. The laboratory also performs translational research exploring the effect of investigational drugs as modifiers of thrombotic risk in SCD patients and SCD mice.</p></div>
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						<a href="https://www.clinicaltrials.gov/ct2/show/NCT00047996">
							
<span>Blood Collection for Research Related to Certain Diseases Involving Blood Vessels</span>

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								Accepting Healthy Volunteers
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												Do you or your child have a disease affecting the blood vessels? This study is collecting blood samples to study the role of inflammation in diseases of the blood vessels, including coronary heart disease and sickle cell disease. To participate, you or your child must be at least 2 years old and either be healthy or have a disease affecting the blood vessels. This study is located in Bethesda, Maryland. 
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            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">A growing population of older adults with sickle cell disease.</div>
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               <span>Authors: </span>Shet AS, Thein SL.
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            <span>
            Clin Geriatr Med
      
                2019 Aug 01</span>;35(3):349-367
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                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/31230736" aria-label="A growing population of older adults with sickle cell disease." class="read-publications">Read Publication</a>
                            
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               <span>Authors: </span>Shet AS, Mendelsohn L, Harper J, Ostrowski D, Henry ER, Gwaabe E, Nichols J, Alayash AI, Eaton WA, Thein SL.
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            Am J Hematol
      
                2019 Apr 01</span>;94(4):E88-E90
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                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/30592074" aria-label="Voxelotor treatment of a patient with sickle cell disease and very severe anemia." class="read-publications">Read Publication</a>
                            
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Interactions of an anti-sickling drug with hemoglobin in red blood cells from a patient with sickle cell anemia.</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Strader MB, Liang H, Meng F, Harper J, Ostrowski DA, Henry ER, Shet AS, Eaton WA, Thein SL, Alayash AI.
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            <span>
            Bioconjug Chem
      
                2019 Mar 20</span>;30(3):569-571
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                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/30794381" aria-label="Interactions of an anti-sickling drug with hemoglobin in red blood cells from a patient with sickle cell anemia." class="read-publications">Read Publication</a>
                            
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">GlycA is not a useful biomarker of inflammation in sickle cell disease.</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Weisman JK, Meeks D, Mendelsohn L, Remaley AT, Sampson M, Allen DT, Nichols J, Shet AS, Thein SL.
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            <span>
            Int J Lab Hematol
      
                2018 Dec 01</span>;40(6):704-709
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                                                    <a href="https://www.ncbi.nlm.nih.gov/pubmed/30152174" aria-label="GlycA is not a useful biomarker of inflammation in sickle cell disease." class="read-publications">Read Publication</a>
                            
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Morphological and Functional Platelet Abnormalities in Berkeley Sickle Cell Mice.</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Arun S Shet, Thomas J Hoffmann, Marketa Jirouskova, Christin A Janczak, Jacqueline R M Stevens, Adewole Adamson, Narla Mohandas, Elizabeth A Manci, Therese Cynober, Barry S Coller
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            <span>
            Blood Cells Mol Dis
      
                2008 Jul 01</span>;41(1):109-118
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                                                    <a href="https://pubmed.ncbi.nlm.nih.gov/18374611/" aria-label="Morphological and Functional Platelet Abnormalities in Berkeley Sickle Cell Mice." class="read-publications">Read Publication</a>
                            
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<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="250" height="250" alt="shet" data-src="/sites/default/files/styles/square_image_250x250/public/2021-07/DSC_0901.jpeg?itok=rdtCCFa-" class="b-lazy image-style-square-image-250x250" />


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                    Arun Shet, M.D.
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