EXHIBIT 12.1

Statement Regarding Computation of Ratio of Earnings to Fixed Charges

(in thousands)



|                                                                                                                                         |  |                         |         |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|---------------------------------------------------------------------------------------------------------------------------------------- |  | ----------------------- | ------- | - | ---- | - | -------- | ---- |  | - | -------- | - |  | ---- | -------- | - |  | - | -------- | -
|                                                                                                                                         |  | Year Ended December 31, |        
|                                                                                                                                         |  | 2002                    |         |   | 2003 |   |          | 2004 |  |   | 2005     |   |  | 2006 |         
|Earnings (loss)                                                                                                                          |  |                         |         |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Pre-tax loss before adjustments for income equity from investees and cumulative effect on prior years of changes in accounting
principle |  | $                       | (87,127 | ) |      | $ | (172,925 | )    |  | $ | (166,618 | ) |  | $    | (169,778 | ) |  | $ | (112,668 | )
|Total fixed charges                                                                                                                      |  | $                       | 381     |   |      | $ | 4,134    |      |  | $ | 8,297    |   |  | $    | 25,937   |   |  | $ | 29,627   |  
|Distributed income of equity investees                                                                                                   |  | $                       | 193     |   |      | $ |         |      |  | $ |         |   |  | $    |         |   |  | $ |         |  
|                                                                                                                                         |  |                         |         |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Total losses before fixed charges                                                                                                        |  | $                       | (86,553 | ) |      | $ | (168,791 | )    |  | $ | (158,321 | ) |  | $    | (143,841 | ) |  | $ | (83,041  | )
|                                                                                                                                         |  |                         |         |   |     
|Fixed Charges                                                                                                                            |  |                         |         |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Interest expenses                                                                                                                        |  | $                       |        |   |      | $ | 3,718    |      |  | $ | 7,527    |   |  | $    | 25,119   |   |  | $ | 28,970   |  
|Assumed interest attributable to rentals                                                                                                 |  | $                       | 381     |   |      | $ | 416      |      |  | $ | 770      |   |  | $    | 818      |   |  | $ | 664      |  
|                                                                                                                                         |  |                         |         |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Total fixed charges                                                                                                                      |  | $                       | 381     |   |      | $ | 4,134    |      |  | $ | 8,297    |   |  | $    | 25,937   |   |  | $ | 29,634   |  
|                                                                                                                                         |  |                         |         |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Deficiency of earnings available to cover fixed charges                                                                                  |  | $                       | 86,934  |   |      | $ | 172,925  |      |  | $ | 166,618  |   |  | $    | 169,778  |   |  | $ | 112,675  |  
|                                                                                                                                         |  |                         |         |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Ratio of earnings available to cover fixed charges                                                                                       |  |                         | n/a     |   |      |   | n/a      |      |  |   | n/a      |   |  |      | n/a      |   |  |   | n/a      |