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		Search Text: Home/News and Events/< Back ToAll News/Certain populations remain underrepresented in heart failure clinical trials

NHLBI IN THE PRESS
                                        
                    Certain populations remain underrepresented in heart failure clinical trials
                    
                    August 22, 2018
    Older patients, women, and racial and ethnic minorities carry a disproportionate burden of heart failure in the general population, but their enrollment in clinical trials has been lower than expected. These findings have raised concerns about the generalizability of heart failure trials. Given important biological differences by age, sex, and race/ethnicity, the risks and benefits of tested therapies may differ based on demographic profiles. In a systematic review of 118 heart failure clinical trials from 2001 to 2016, researchers recently found that the average age of participants was 65 years and 27% were women, suggesting thatolder patients and women are consistently underrepresented. Race or ethnicity data were reported in less than half of trials, and when reported, such data showedthatenrollment of nonwhite patients increased steadily from 13% to 30% over time. According to the authors, future efforts should focus on improving the reporting of age, sex, and race/ethnicity data in heart failure clinical trials and enhancing the representativeness of trial populations.The study, which was partly funded by the NHLBI, was published in the journal*JAMA Cardiology*.
                        Media Coverage
                
    August 22, 2018
      |
            TCTMD
                Diversity in Heart Failure Trials Still Falls Short
                                                                                                
        August 22, 2018
      |
            MD Magazine
                Women, Minorities Significantly Underrepresented in Heart Failure Trials
                                                                                                
        August 24, 2018
      |
            Cardiovascular Business
                Review: Heart failure trials lack women, older patients Back To Top Link
  

        

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