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		Search Text: Clinical Trials
					
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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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      How Clinical Trials Work
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Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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          CLEARAcute Respiratory Distress SyndromeAlpha-1 Antitrypsin DeficiencyAnemiaAngina (Chest Pain)Aortic AneurysmAplastic AnemiaArrhythmiasAsthmaAtherosclerosisAtrial FibrillationBleeding DisordersBlood CholesterolBlood Clotting DisordersBronchiectasisBronchitisCardiac ArrestCardiac CatheterizationCardiogenic ShockCardiomyopathyChildhood ObesityCircadian Rhythm DisordersConduction DisordersCongenital Heart DefectsCOPDCoronary Artery Bypass GraftingCoronary Heart DiseaseCystic FibrosisDeep Vein Thrombosis (DVT)DefibrillatorsGet Regular Physical ActivityHeart-Healthy LivingHeart AttackHeart FailureHeart InflammationHeart SurgeryHeart TestsHeart TransplantHeart TreatmentsHeart Valve DiseasesHemolytic AnemiaHigh Blood PressureHigh Blood TriglyceridesHow Sleep WorksHow the Heart WorksHow the Lungs WorkIdiopathic Pulmonary FibrosisInsomniaLAMLong QT SyndromeLow Blood PressureMarfan SyndromeMetabolic SyndromeNarcolepsyNewborn Breathing ConditionsOverweight and ObesityPacemakersPeripheral Artery DiseasePhysical Activity and Your HeartPlatelet DisordersPleural DisordersPneumoniaPolycythemia VeraPrimary Ciliary DyskinesiaPulmonary HypertensionPulmonary RehabilitationSarcoidosisSickle Cell DiseaseSleep ApneaSleep Deprivation and DeficiencySleep StudiesSmoking and Your HeartTests for Lung DiseaseThalassemiaThe LungsTranscatheter Aortic Valve Replacement (TAVR)Treatments for Blood DisordersVasculitisVenous Thromboembolism(-)
Ventilator/Ventilator SupportWhat Is Physical Activity?Women and Heart Disease

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Showing 1 - 6 out of 6 results
      
      Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients With High-Flow Nasal Cannula
      Recruiting
                          Tennessee
        The purpose of this study is to compare reintubation rates and outcomes of patients treated with high-flow nasal canula oxygen therapy (HFNC) and patients treated with provider choice of standard care.
      Ventilator/Ventilator Support
                          Adult, Older Adult
    Telehealth-Enabled, Real-time Audit and Feedback for Clinician AdHerence (TEACH)
      Recruiting
                          Utah
        The purpose of this trial is to evaluate if augmenting a usual audit and feedback implementation approach with telehealth-enabled support improves coordinated spontaneous awakening/breathing trials and patient outcomes for mechanically ventilated patients.
      Ventilator/Ventilator Support
                          All Ages
    Goal-Directed Sedation in Mechanically Ventilated Infants and Children
      Recruiting
                          Tennessee
        Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs. Universally prescribed sedative medications-the GABA-ergic benzodiazepines-worsen this brain organ dysfunction and independently prolong duration of ventilation and ICU stay, and the available alternative sedation regimen using dexmedetomidine, an alpha-2 agonist, has been shown to be superior to benzodiazepines in adults, and may mechanistically impact outcomes through positive effects on innate immunity, bacterial clearance, apoptosis, cognition and delirium. The mini-MENDS trial will compare dexmedetomidine and midazolam, and determine the best sedative medication to reduce delirium and improve duration of ventilation, and functional, psychiatric, and cognitive recovery in our most vulnerable patients-survivors of pediatric critical illness.
      Ventilator/Ventilator Support
                          Child
    Oxygenation Instability and Maturation of Control of Breathing in Premature Infants
      Recruiting
                          Florida
        Is your newborn in the NICU at Holtz Children’s Hospital in Miami?
                    Newborns born very prematurely often need oxygen therapy or ventilation to help them breathe and survive. This study will help doctors understand how changes in oxygen and carbon dioxide levels while newborns are getting treatment affect how their lungs develop. While your newborn is in the newborn neonatal intensive care unit (NICU), researchers will record his or her oxygen and carbon dioxide levels, heart rate, and other measures. To participate in this study, your newborn must have been born prematurely between 23 and 28 weeks’ gestation, be less than 28 days old, and be receiving oxygen therapy. This study is located in Miami, Florida.
      Ventilator/Ventilator Support
              Newborn Breathing Conditions
                          All Ages
    Self-management of Sedative Therapy by Ventilated Patients
      Recruiting
                          Minnesota
        Are you or a loved one on a ventilator in the hospital in Minnesota? 
                    This study is finding out whether people who are on a ventilator sleep better and have less anxiety if they can control their own sedation medicine. To participate in this study, you must be at least 18 years old and receiving mechanical ventilation while hospitalized. This study is located in Minneapolis and Rochester, Minnesota.
      Respiratory Failure
              Ventilator/Ventilator Support
                          Adult, Older Adult
    Real-time Effort Driven VENTilator Management (REDvent)
      Recruiting
                          California
        Is your child on a ventilator at Children’s Hospital Los Angeles? 
                    Ventilators can sometimes weaken the muscles around the lungs, especially in children. This study is testing whether a new computer method to control ventilators can help prevent muscle weakness in children. To participate in this study, your child must be between 1 month and 18 years old and have been on a ventilator for less than 48 hours (or 72 if they were transferred from another hospital) because of a serious lung disease. This study is located in Los Angeles, California.
      Respiratory Failure
              Ventilator/Ventilator Support
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