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    Home< Back ToHealth TopicsSickle Cell Disease

  What Is Sickle Cell Disease?
                                                  
                          Symptoms
                                                  
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                          Causes and Risk Factors
                                                  
                          Sickle Cell Trait
                                                  
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                          How Sickle Cell Disease May Affect Your Health
                                                  
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          Sickle Cell Disease
Sickle Cell DiseaseWhat Is Sickle Cell Disease?

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smiling kidsSickle cell disease is a group of inherited red blood cell disorders that affect hemoglobin, the protein that carries oxygen through the body. Normally, red blood cells are disc-shaped and flexible enough to move easily through the blood vessels. In sickle cell disease, red blood cells become crescent- or “sickle”-shaped due to a genetic mutation. These sickled red blood cells do not bend or move easily and can block blood flow to the rest of the body.The blocked blood flow through the body can lead to serious problems, including stroke, eye problems, infections, and episodes of pain called pain crises.Sickle cell disease is a lifelong illness. A bone marrow transplantis currently the only cure for sickle cell disease. Gene therapy is also being explored as another potential cure, but there are other effectivetreatmentsthat can reducesymptomsand prolong life. If you have sickle cell disease, your healthcare team will work with you on a treatment plan to reduce your symptoms andmanage the condition.The condition affects more than 100,000 people in the United States and 20 million people worldwide. In the United States, most people who have sickle cell disease are of African ancestry or identify themselves as Black.About 1 in 13 Black or African American babies are born with sickle cell trait.About 1 in every 365 Black or African American babies are born with sickle cell disease.Many people who come from Hispanic, Southern European, Middle Eastern, or Asian Indian backgrounds also have sickle cell disease.NHLBI is leading and supporting research and clinical trials to find a cure for sickle cell disease.Sickle cell disease fact sheet
                                FACT SHEET
      
                    
                    

                                            
            Sickle Cell Disease Fact Sheet

Learn basics about sickle cell disease, including symptoms and treatment options.
      
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