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<article class="node node--type-research-topics node--theme-red node--view-mode-full">

  <div class="menu-topic-bar">Research Topics</div>
  
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	<span class="a2a_kit a2a_kit_size_24 addtoany_list" data-a2a-url="https://www.nhlbi.nih.gov/research/clotting-disorders" data-a2a-title="Blood Clotting Disorders Research">
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                  <h1 class="field field--name-title field--type-string field--label-hidden responsive-container responsive-container-constrained field__item">Blood Clotting Disorders Research</h1>
      
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                    <div class="field field--name-field-health-topic-summary field--type-text-long field--label-hidden field__item"><p>As part of its broader commitment to research on blood disorders and blood safety, the NHLBI leads and supports research and programs on clotting disorders in the United States and around the world. Research supported by the NHLBI has provided more information about the risk factors, causes, and outcomes of people who have inherited or acquired clotting disorders. Many current studies focus on examining the risk factors to prevent blood clot formation and optimizing treatment protocols for patients with clotting disorders.</p></div>
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<h2 class="field--name-field-component-section-titl component-section-section-title">NHLBI research that really made a difference</h2>

            <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden clearfix field__item"><ul><li><strong>Medicine dosing:</strong> The <a href="https://www.clinicaltrials.gov/ct2/show/NCT00839657" rel="noreferrer">Clarification of Optimal Anticoagulation through Genetics (COAG) study</a> was a large-scale clinical study sponsored by the NHLBI that studied participants’ DNA to help determine the proper dose of the blood thinner warfarin for each participant. Results from this study were published in the <a href="https://pubmed.ncbi.nlm.nih.gov/24251361/" rel="noreferrer">New England Journal of Medicine</a>. You can also read about common Questions and Answers on NHLBI’s COAG study and how <a href="https://directorsblog.nih.gov/2017/10/03/precision-medicine-making-warfarin-safer/" rel="noreferrer">precision medicine may help make warfarin safer</a>.</li>
	<li><strong>Women and blood clots:</strong> Women receiving hormone therapy have a higher risk of developing blood clots. The <a href="https://www.nhlbi.nih.gov/science/womens-health-initiative-whi" rel="noreferrer">Women’s Health Initiative (WHI)</a> is one of the largest women’s health projects ever launched in the United States, with more than 161,000 participants at 40 clinical centers. The WHI found that the use of estrogen plus progestin hormone therapy after menopause increased the risk of blood clots.</li>
	<li><strong>Causes of disseminated intravascular coagulation (DIC):</strong> NHLBI-supported studies laid the groundwork for understanding <a href="https://www.nhlbi.nih.gov/health/disseminated-intravascular-coagulation" rel="noreferrer">disseminated intravascular coagulation (DIC)</a>, an acquired clotting disorder. These initial studies were critical for later studies on treatments for the condition. For example, studies in the 1980s, such as <a href="https://pubmed.ncbi.nlm.nih.gov/2521800/" rel="noreferrer">this one</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/3924142/" rel="noreferrer">this one</a>, determined that the clotting factor protein C, which prevents clots, is activated in DIC and plays a major role in controlling the disease. Having low levels of protein C, such as from genetic mutatio<span><span class="entity-embed node entity-embed-glossary_term"><a class="glossary-term" href="#" title="Definition of mutation " alt="Definition of mutation" data-term="mutation" data-pronunciation="myoo-TAY-shun" data-definition="Any change in a nucleic acid sequence, such as DNA or RNA." role="link">
		mutations
	</a></span></span>, makes people more likely to develop DIC if they have a bacterial infection. Low protein C levels are also linked to blood clots.</li>
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<h2 class="field--name-field-component-section-titl component-section-section-title">Current research funded by the NHLBI</h2>

            <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden clearfix field__item"><p>Our <a href="https://www.nhlbi.nih.gov/about/scienfic-divisions/division-blood-diseases-and-resources" rel="noreferrer">Division of Blood Diseases and Resources (DBDR)</a> and <a href="https://www.nhlbi.nih.gov/about/scientific-divisions/division-lung-diseases" rel="noreferrer">Division of Lung Diseases (DLD)</a> fund research on blood clots and clotting disorders. DBDR-supported research improves our understanding of normal and abnormal blood, blood clotting, and blood flow. It also supports scientific advances in biomarkers to diagnose blood conditions and in therapeutics to treat them. The DLD funds research on the causes, diagnosis, prevention, and treatment of lung diseases. Its Lung Vascular Biology Program supports research on pulmonary embolism, including understanding how the condition develops.</p>


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            <div class="field field--name-field-callout-description field--type-text-long field--label-hidden field__item">  <p>Find funding opportunities and program contacts for clotting disorder research.</p>

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<h3>Current research on acquired clotting disorders</h3>

<ul><li><strong>Sepsis and acquired blood clots:</strong> Septic shock can cause blood clots throughout the body that lead to DIC. The risk of death doubles in patients who have sepsis that are diagnosed with DIC. Research funded by the NHLBI seeks to determine the <a href="https://reporter.nih.gov/search/Jo_AiJ7wFEaU8VpXj58qQg/project-details/10150075" rel="noreferrer">mechanism of the formation of blood clots</a> throughout the body during septic shock. Additional NHLBI-funded studies are examining a new nanoparticle drug that helps prevent blood clots in sepsis.</li>
	<li><strong>Safer treatments for antiphospholipid syndrome (APS):</strong> <a href="https://www.nhlbi.nih.gov/health/antiphospholipid-syndrome" rel="noreferrer">Antiphospholipid syndrome (APS)</a> poses a lifelong risk of blood clots. People with APS typically are prescribed blood thinner medicine that they must take for the rest of their lives to prevent complications of blood clots. Due to the known side effects of blood thinner medicine, NHLBI-funded scientists are actively investigating <a href="https://reporter.nih.gov/search/TbzuEy7aXUujvowpqkOZhQ/project-details/10213122" rel="noreferrer">safer alternative treatment options</a> for people with APS.</li>
</ul><p>Find more NHLBI-funded studies on <a href="https://reporter.nih.gov/search/iReWOc7ZIUSH2_wPfYegpw/projects" rel="noreferrer">acquired clotting disorders</a> at NIH RePORTER.</p>

<h3>Current research on treatments for clotting disorders</h3>

<ul><li><strong>The role of enzymes:</strong> Certain enzymes in the blood, called thiol isomerases, are necessary for blood clot formation. NHLBI-funded researchers are now <a href="https://reporter.nih.gov/search/U04l-8OqREuPH3suUky9yA/project-details/10094223" rel="noreferrer">conducting studies to target these enzymes</a> to stop blood clots from forming in disorders like sepsis, APS, and inherited clotting disorders.</li>
	<li><strong>Warfarin dosage:</strong> Many people with clotting disorders and a history of blood clots are prescribed warfarin to prevent more blood clots from forming. NHLBI-funded scientists are researching ways to <a href="https://reporter.nih.gov/search/punL1mB9K0-oGOPZEE4yng/project-details/9049275" rel="noreferrer">personalize the dosage</a> based on each patient’s unique genetic and clinical profile.</li>
</ul><p>Find more NHLBI-funded studies on <a href="https://reporter.nih.gov/search/Q9g5MI3kcECreG_AGbr6Mg/projects" rel="noreferrer">treatment for clotting disorders</a> at NIH RePORTER.</p>

<h3>Current research on clotting disorder risk factors</h3>

<p>NHLBI-funded researchers are developing tools to help predict who is at greater risk of blood clots with the goal of helping to prevent them.</p>

<ul><li><strong>Oral contraceptives:</strong> People who take oral contraceptives are at an increased risk of developing blood clots. Researchers are conducting <a href="https://reporter.nih.gov/search/ZszE-EhZb0mdx7XEgcF1JQ/project-details/10120016" rel="noreferrer">studies</a> to examine the effects of oral contraceptive medicine on genetic and nongenetic factors in the blood that form blood clots. Other NHLBI-funded studies are assessing these factors to <a href="https://reporter.nih.gov/search/ZszE-EhZb0mdx7XEgcF1JQ/project-details/10140411" rel="noreferrer">create a risk-prediction model</a> that could help determine who may be at increased risk of blood clots caused by oral contraceptives.</li>
	<li><strong>Trauma and blood clot risk:</strong> Many hospitalized trauma patients develop blood clots. NHLBI-funded researchers are <a href="https://reporter.nih.gov/search/ZszE-EhZb0mdx7XEgcF1JQ/project-details/10172926" rel="noreferrer">developing a risk tool</a> to accurately predict who is more likely to develop a dangerous blood clot after a traumatic illness or injury.</li>
	<li><strong>Atrial fibrillation and blood clots:</strong> <a href="https://www.nhlbi.nih.gov/health/atrial-fibrillation" rel="noreferrer">Atrial fibrillation</a> is one of the most common types of arrhythmias, or irregular heart rhythms. Sometimes atrial fibrillation goes away on its own, but other times, it can lead to blood clots. NHLBI-funded researchers are developing <a href="https://reporter.nih.gov/search/JiAvbZbP9EmhiZQM-shMAw/project-details/10226154" rel="noreferrer">algorithms</a> to predict the risk of blood clots in people with atrial fibrillation.</li>
</ul><p>Find more NHLBI-funded studies on the <a href="https://reporter.nih.gov/search/B0nqD2hI1EK2CZby3fPymw/projects" rel="noreferrer">risk factors for blood clots</a> at NIH RePORTER.</p>
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<h2 class="field--name-field-component-section-titl component-section-section-title">Blood clotting disorder research labs at the NHLBI</h2>

            <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden clearfix field__item"><p>Our <a href="https://www.nhlbi.nih.gov/about/divisions/division-intramural-research" rel="noreferrer">Division of Intramural Research</a> includes some of the investigators at the NHLBI who are actively engaged in the study of blood clots and clotting disorders.</p>

<p>Read more about these projects and <a href="https://www.nhlbi.nih.gov/research/clinical-trials?f%5B0%5D=disease_or_condition_name%3ABlood%20Clotting%20Disorders" rel="noreferrer">ongoing clinical trials</a>.</p></div>
      
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<h2 class="field--name-field-component-section-titl component-section-section-title">Related clotting disorder programs</h2>

            <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden clearfix field__item"><ul><li>In February 2021, the NIH launched the <a href="https://www.nih.gov/research-training/medical-research-initiatives/activ" rel="noreferrer">Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) initiative</a>. As a part of the initiative, researchers funded in part by the NHLBI are exploring the use of a blood thinner to prevent blood clots in patients who have been discharged from the hospital following a diagnosis of <a href="https://www.covid19treatmentguidelines.nih.gov/overview/clinical-spectrum/" rel="noreferrer">moderate-to-severe COVID-19</a>.</li>
	<li>The <a href="https://www.nhlbi.nih.gov/science/vascular-interventionsinnovations-and-therapeutic-advances-vita-program" rel="noreferrer">Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program</a> is a translational program that supports and accelerates early-stage development of promising diagnostics and treatments. The VITA Program seeks to address unmet clinical needs for vascular diseases, including blood clotting disorders, particularly in underserved communities.</li>
	<li>The <a href="https://www.tacticproject.org/" rel="noreferrer">Trans-Agency Research Consortium for Trauma-Induced Coagulopathy (TACTIC)</a> research program is a partnership between the NHLBI and the Department of Defense to study the disruptions in the normal process of blood clotting that occur in people who experience severe trauma.</li>
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<h2 class="field--name-field-component-section-titl component-explore-more-research-section-title">Explore more NHLBI research on blood clotting disorders</h2>

            <div class="field field--name-field-component-section-st field--type-string field--label-hidden visually-hidden field__item">Explore more NHLBI research on blood clotting disorders</div>
      
            <div class="field field--name-field-component-section-desc field--type-text-long field--label-hidden field__item"><p>The sections above provide you with the highlights of NHLBI-supported research on blood clotting disorders. You can explore the full list of NHLBI-funded studies on the <a href="https://reporter.nih.gov/search/JiAvbZbP9EmhiZQM-shMAw/projects" rel="noreferrer">NIH RePORTER</a>.</p></div>
      
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            <div class="field field--name-field-callout-description-notrim field--type-text-long field--label-hidden field__item"><p>To find more studies:</p>

<ul><li>Type your search words into the <b>Quick Search</b> box and press enter. </li>
	<li>Check <b>Active Projects</b> if you want current research.</li>
	<li>Select the <b>Agencies</b> arrow, then the <b>NIH</b> arrow, then check <b>NHLBI</b>.</li>
</ul><p>If you want to sort the projects by budget size <span style="font-size:11.0pt"><span style="line-height:107%"><span style="font-family:"Calibri",sans-serif">—</span></span></span> from the biggest to the smallest <span style="font-size:11.0pt"><span style="line-height:107%"><span style="font-family:"Calibri",sans-serif">—</span></span></span> click on the <b>FY Total Cost by IC</b> column heading.</p>
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  <div class="field field--name-field-last-updated field--type-datetime field--label-hidden responsive-container responsive-container-constrained field__item">Last updated on <time datetime="2022-05-06T12:00:00Z" class="datetime"><span>May 06, 2022</span></time>
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