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		Search Text: Clinical Trials
					
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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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      How Clinical Trials Work
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      Who Can Participate
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      Benefits, Risks & Safety Measures
Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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CLEARAnemiaAplastic AnemiaArrhythmiasAtrial FibrillationCardiomyopathyCongenital Heart DefectsCoronary Artery Bypass GraftingCoronary Heart DiseaseHeart SurgeryHemolytic AnemiaIdiopathic Pulmonary FibrosisInterstitial Lung DiseasesLAMLung Disease TreatmentsPlatelet DisordersPolycythemia VeraRespiratory FailureStrokeVentilator/Ventilator Support

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Showing 1 - 10 out of 16 results
      
      The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial
      Recruiting
                          Multiple Locations
        DIVA is a pragmatic randomized clinical trial (RCT) to determine: among (P) preterm infants born 24-27 6/7 weeks gestation undergoing extubation from mechanical ventilation, whether (I) Non-invasive neurally adjusted ventilatory assist (NIV-NAVA) (C) compared with Non-synchronized nasal intermittent positive pressure ventilation (NS-NIPPV), will reduce the incidence of (O) extubation failure within (T) 5 days (120 hours) of extubation.
      Interstitial Lung Diseases
              Lung Disease Treatments
                          Child
    Telehealth-Enabled, Real-time Audit and Feedback for Clinician AdHerence (TEACH)
      Recruiting
                          Utah
        The purpose of this trial is to evaluate if augmenting a usual audit and feedback implementation approach with telehealth-enabled support improves coordinated spontaneous awakening/breathing trials and patient outcomes for mechanically ventilated patients.
      Ventilator/Ventilator Support
                          All Ages
    Telehealth-Enabled, Real-time Audit and Feedback for Clinician AdHerence (TEACH)
      Recruiting
                          Utah
        The purpose of this trial is to evaluate if augmenting a usual audit and feedback implementation approach with telehealth-enabled support improves coordinated spontaneous awakening/breathing trials and patient outcomes for mechanically ventilated patients.
      Respiratory Failure
                          All Ages
    Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS)
      Recruiting
                          Multiple Locations
        Does your child have Down Syndrome? Did they have a complete atrioventricular septal defect (CAVSD) repair within the first year of their life? Researchers in this study are investigating how the
brain develops in children with Down Syndrome who have congenital heart disease. To participate, your child must be between 5 and 12 years old and have Down Syndrome. The study will enroll children who have congenital heart disease as well as children who do not have congenital heart disease. The study is taking place in locations in Delaware, Georgia, Indiana, Massachusetts, Michigan, Missouri, New York, Ohio, Pennsylvania, South Carolina, Texas, Utah, Washington, D.C., and Toronto, Canada
      Congenital Heart Defects
                          Child
                                      Accepting Healthy Volunteers
    Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
      Recruiting
                          Multiple Locations
        Are you 75 years old or older and interested in participating in a clinical trial where researchers are studying whether statins, which are often used to treat high cholesterol, can help improve heart and brain health. To participate, you cannot have cardiovascular disease or dementia. The study is taking place at locations in Alabama, Arizona, Arkansas, California, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Nebraska, Nevada, New York, North Carolina, Ohio, Pennsylvania, Rhode Island, South Carolina, Tennessee, Texas, Utah, Virginia, West Virginia, Wisconsin, and Puerto Rico.
      Coronary Heart Disease
                          Older Adult
                                      Accepting Healthy Volunteers
    Safety and Durability of Sirolimus for Treatment of LAM
      Recruiting
                          Multiple Locations
        Are you an adult female with LAM? If so, you may be able to participate in this clinical study where researchers are observing patients who are taking or have taken a certain kind of medication, mammalian target of rapamycin (mTOR), to treat lymphangioleiomyomatosis, also known as LAM. You must be at least 18 years old to take part. The study is taking place at locations in California, Colorado, Florida, Georgia, Illinois, Massachusetts, Michigan, Minnesota, Missouri, New York, Ohio, Oregon, Pennsylvania, South Carolina, Tennessee, Texas, Utah, and Washington.
      LAM
                          Adult, Older Adult
                                            Female
    A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)
      Recruiting
                          Multiple Locations
        This trial will compare time from randomization to failure of treatment or death from any cause of IST versus URD BMT when used as initial therapy to treat Severe Aplastic Anemia.
      Anemia
                          Child, Adult
    Congenital Heart Disease GEnetic NEtwork Study (CHD GENES).
      Recruiting
                          Multiple Locations
        Do you or one of your children have a congenital heart defect?
                    This study will find both common genetic causes of congenital heart disease and ways that genes influence results of medical treatment. To participate in this study, you or your child must have congenital heart disease. This study is located in Los Angeles, Palo Alto, and San Francisco, California; New Haven, Connecticut; Boston, Massachusetts; New York and Rochester, New York; Philadelphia, Pennsylvania; and Salt Lake City, Utah.
      Congenital Heart Defects
                          All Ages
    Transplants With Unlicensed Preserved Cord Blood
      Recruiting
                          Multiple Locations
        Are you scheduled for a stem cell transplant with cord blood?
                    This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.
      Anemia
              Hemolytic Anemia
              Aplastic Anemia
                          All Ages
    Autoantibody Reduction for Acute Exacerbations of Idiopathic Pulmonary Fibrosis (STRIVE-IPF)
      Recruiting
                          Multiple Locations
        Are you between 40 and 85 with worsening idiopathic pulmonary fibrosis?
                    This study aims to test a new combination treatment for acute exacerbations, a life-threatening complication of idiopathic pulmonary fibrosis (IPF) that has no approved treatment. The treatment is meant to help stop part of the immune system from further injuring the lung tissue. To participate in this study, you must be between 40 and 85 years old and have worsening IPF. This study is located in Birmingham, Alabama; Boston, Massachusetts; Philadelphia, Pennsylvania; and Pittsburgh, Pennsylvania.
      Idiopathic Pulmonary Fibrosis
              Interstitial Lung Diseases
                          Adult, Older Adult
  
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