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		Search Text: Clinical Trials
					
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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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      How Clinical Trials Work
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      Who Can Participate
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      Benefits, Risks & Safety Measures
Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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          CLEARAcute Respiratory Distress SyndromeAlpha-1 Antitrypsin DeficiencyAnemiaAngina (Chest Pain)Aortic AneurysmAplastic AnemiaArrhythmiasAsthmaAtherosclerosisAtrial FibrillationBleeding DisordersBlood CholesterolBlood Clotting DisordersBronchiectasisBronchitisCardiac ArrestCardiac CatheterizationCardiogenic ShockCardiomyopathyChildhood ObesityCircadian Rhythm DisordersConduction Disorders(-)
Congenital Heart DefectsCOPDCoronary Artery Bypass GraftingCoronary Heart DiseaseCystic FibrosisDeep Vein Thrombosis (DVT)DefibrillatorsGet Regular Physical ActivityHeart AttackHeart FailureHeart InflammationHeart SurgeryHeart TestsHeart TransplantHeart TreatmentsHeart Valve DiseasesHemolytic AnemiaHigh Blood PressureHigh Blood TriglyceridesHow Sleep WorksHow the Heart WorksHow the Lungs WorkIdiopathic Pulmonary FibrosisInsomniaInterstitial Lung DiseasesLAMLong QT SyndromeLow Blood PressureLung Disease TreatmentsMarfan SyndromeMetabolic SyndromeNarcolepsyNewborn Breathing ConditionsOverweight and ObesityPacemakersPeripheral Artery DiseasePhysical Activity and Your HeartPlatelet DisordersPleural DisordersPneumoniaPolycythemia VeraPrimary Ciliary DyskinesiaPulmonary HypertensionPulmonary RehabilitationRespiratory FailureSarcoidosisSickle Cell DiseaseSleep ApneaSleep Deprivation and DeficiencySleep StudiesSmoking and Your HeartStrokeTests for Lung DiseaseThalassemiaThe LungsTranscatheter Aortic Valve Replacement (TAVR)Treatments for Blood DisordersVasculitisVenous ThromboembolismVentilator/Ventilator SupportWhat Is Physical Activity?Women and Heart Disease

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Clear AllCongenital Heart Defects
Showing 1 - 10 out of 12 results
      
      Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome
      Recruiting
                          New York
              Pennsylvania
        22q11.2 deletion syndrome is a genetic disorder that can cause heart defects, facial abnormalities, and developmental and learning disabilities. The severity of the disorder can vary widely among people. This study will analyze DNA from people with 22q11.2 deletion syndrome to identify genetic variations that may affect the severity of the disorder.
      Congenital Heart Defects
                          All Ages
    Assessing and Promoting Resilience in Patients With Adult Congenital Heart Disease
      Recruiting
                          Washington
        Are you an adult with congenital heart disease? If so, you may be able to participate in a clinical trial where researchers are testing a program for stress management for people with congenital heart disease. Participants must be 18 years old and have complex congenital heart disease. To participate, you must also receive care in the University of Washington health system. The study is
taking place in Seattle, Washington.
      Congenital Heart Defects
                          Adult, Older Adult
    Ventricular and Pulmonary Vascular Reserve After the Fontan Operation
      Recruiting
                          Minnesota
        Are you an adult who has had Fontan palliation operation? If so, you may be able to join a clinical trial where researchers learn more about how the heart and lungs work after a Fontan palliation.  Researchers will perform a procedure called a cardiac catheterization while participants exercise to see how well the heart is working. Participants must be at least 18 years old. The study is taking place in Rochester, Minnesota.
      Heart Failure
              Congenital Heart Defects
                          Adult, Older Adult
    Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS)
      Recruiting
                          Multiple Locations
        Does your child have Down Syndrome? Did they have a complete atrioventricular septal defect (CAVSD) repair within the first year of their life? Researchers in this study are investigating how the
brain develops in children with Down Syndrome who have congenital heart disease. To participate, your child must be between 5 and 12 years old and have Down Syndrome. The study will enroll children who have congenital heart disease as well as children who do not have congenital heart disease. The study is taking place in locations in Delaware, Georgia, Indiana, Massachusetts, Michigan, Missouri, New York, Ohio, Pennsylvania, South Carolina, Texas, Utah, Washington, D.C., and Toronto, Canada
      Congenital Heart Defects
                          Child
                                      Accepting Healthy Volunteers
    Congenital Heart Disease GEnetic NEtwork Study (CHD GENES).
      Recruiting
                          Multiple Locations
        Do you or one of your children have a congenital heart defect?
                    This study will find both common genetic causes of congenital heart disease and ways that genes influence results of medical treatment. To participate in this study, you or your child must have congenital heart disease. This study is located in Los Angeles, Palo Alto, and San Francisco, California; New Haven, Connecticut; Boston, Massachusetts; New York and Rochester, New York; Philadelphia, Pennsylvania; and Salt Lake City, Utah.
      Congenital Heart Defects
                          All Ages
    Genetics of Congenital Heart Disease
      Recruiting
                          Ohio
        Are you an adult with congenital heart disease?
                    This study uses whole exome sequencing and other genetic tests to identify causes of congenital heart diseases that occur in individuals and families. To participate in this study, you must be an adult with congenital heart disease with or without a family member with congenital heart disease. This study is located in Columbus, Ohio.
      Congenital Heart Defects
                          All Ages
                                      Accepting Healthy Volunteers
    The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Congenital Heart Disease (BCAS-Adult)
      Recruiting
                          Massachusetts
        Are you a greater Boston resident aged 24 to 30?
                    This study aims to bridge the gap in knowledge between known executive function deficits in childhood congenital heart disease and adult well-being. The study is Recruitinghealthy volunteers. To participate in this study, you must be between the ages of 24 and 30, live in the greater Boston area, read fluently in English, and not have metal implants, a pacemaker, or orthodontia that would prevent MRI. This study is located in Boston, Massachusetts.
      Congenital Heart Defects
                          Adult
                                      Accepting Healthy Volunteers
    Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System
      Recruiting
                          Maryland
        Do you have coronary heart disease or are you healthy and would like to participate in research? This study is comparing how well two types of magnetic resonance imaging (MRI) scanners can detect different types of heart diseases, such as coronary heart disease, heart failure, congenital heart disease, and heart valve disease. The new type of MRI scanner in this study uses less energy than a traditional scanner and may be suitable for people who have metal devices in their bodies. This study is located in Bethesda, Maryland.
      Congenital Heart Defects
              Coronary Heart Disease
              Heart Failure
              Heart Valve Diseases
                          Adult, Older Adult
                                      Accepting Healthy Volunteers
    Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise
      Recruiting
                          Wisconsin
        Does your developing baby have a heart defect? Have you had a stillborn baby?
                    This study tests a new technology to measure fetal heart activity and find possible problems early. These problems include fetal arrhythmia and conduction disorders such as Brugada syndrome. To participate in this study, you must be at least 18 years old and pregnant, and have one of five high-risk complications of pregnancy: a fetus with a major congenital heart defect, hydrops, or gastroschisis; a previous unexplained stillbirth; or twins who share a placenta. This study is located in Madison and Milwaukee, Wisconsin.
      Arrhythmias
              Congenital Heart Defects
              Conduction Disorders
                          Adult, Older Adult
                                            Female
    Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development
      Recruiting
                          Georgia
        Is your child undergoing heart surgery for congenital heart disease?
                    This study aims to help researchers better understand the developing heart and what controls the strength of its beats by comparing it to adult hearts. Researchers will study small pieces of the heart that are removed as a normal part of surgery or repair for children with congenital heart disease. To participate in this study, your child must be undergoing cardiopulmonary bypass surgery and be 18 years old or younger. The study is located in Atlanta, Georgia.
      Congenital Heart Defects
              Heart Valve Diseases
                          Child, Adult
  
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