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      <div>Sarcoidosis</div>

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      <div>Sarcoidosis</div>

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                  <h1  class="field field--name-title field--type-string field--label-hidden responsive-container responsive-container-constrained field__item"><span class="ht-kicker">Sarcoidosis </span>Causes and Risk Factors<hr>
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	<span class="a2a_kit a2a_kit_size_24 addtoany_list" data-a2a-url="https://www.nhlbi.nih.gov/health/sarcoidosis/causes" data-a2a-title="Causes and Risk Factors">
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<h2 class="field--name-field-component-section-titl component-section-section-title">What causes sarcoidosis?</h2>

            <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden clearfix field__item"><p>Your immune system creates <span><span class="entity-embed node entity-embed-glossary_term"><a class="glossary-term" href="#" title="Definition of inflammation " alt="Definition of inflammation" data-term="inflammation" data-pronunciation="IN-fluh-MAY-shun" data-definition="A reaction to injury of the body. The signs of inflammation are swelling, redness, or pain." role="link">
		inflammation
	</a></span></span> to help defend you against germs and sickness. But in sarcoidosis, inflammation goes off track and the cells in your immune system form lumps, called granulomas, in your body. Over time, inflammation may lead to permanent scarring of organs.</p>

<figure role="group" class="align-center b-loaded caption caption-img "><img alt="    The illustration shows the major signs and symptoms of sarcoidosis and the organs involved." data-entity-type="file" data-entity-uuid="08d8b545-10b7-4ae0-80e0-f330d1c4b4ee" data-image-style="" width="500" height="294" data-src="/sites/default/files/inline-images/sarcoidosis_symptoms_0.jpg" src="/modules/custom/nhlbi_blazy/images/clear.png" class="b-lazy" /><figcaption><em>The  illustration shows a close-up view of granulomas, or lumps, and scarring on the lungs. It also shows larger than normal lymph nodes near the lungs.</em></figcaption></figure><p>Studies suggest that some immune system triggers can lead to sarcoidosis in certain people. Triggers can include infections without symptoms or coming into contact with substances in the environment. Your <span><span class="entity-embed node entity-embed-glossary_term"><a class="glossary-term" href="#" title="Definition of gene " alt="Definition of gene" data-term="gene" data-pronunciation="jeen" data-definition="The unit that passes heredity from parents to children. Genes are pieces of DNA and contain information for making a specific protein." role="link">
		genes
	</a></span></span> can affect how your immune system reacts to a trigger.</p></div>
      
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<h2 class="field--name-field-component-section-titl component-section-section-title">What raises your risk of sarcoidosis?</h2>

            <div class="field field--name-field-component-section-content field--type-text-long field--label-hidden clearfix field__item"><p>There are many risk factors for sarcoidosis. Some risk factors, such as where you work, can be changed. But your age, family history, and many other risk factors cannot be changed.</p>

<ul><li><strong>Age: </strong>You can get sarcoidosis at any age, but the risk goes up as you get older, especially after age 55.</li>
	<li><strong>Environment:</strong> Living or working near insecticides, mold, or other substances that may cause inflammation raises your risk. You may be around these substances if you are in health care or the automotive industry or are a farmer or firefighter.</li>
	<li><strong>Family history and genetics:</strong> Having a close relative with sarcoidosis raises your risk.</li>
	<li><strong>Medicines:</strong> Certain types of HIV medicines and <a href="https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/monoclonal-antibodies" rel="noreferrer">monoclonal antibodies</a> used to treat cancer or overactive immune system can raise your risk.</li>
	<li><strong>Race or ethnicity:</strong> Your risk is higher if you are of African or Scandinavian descent.</li>
	<li><strong>Sex:</strong> Women are more likely to have sarcoidosis, although men can also have it.</li>
</ul><p>Other medical conditions, such as lymphoma, a type of blood cancer, can also lead to sarcoidosis.</p></div>
      
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  <div class="field field--name-field-last-updated field--type-datetime field--label-hidden responsive-container responsive-container-constrained field__item">Last updated on <time datetime="2022-03-24T12:00:00Z" class="datetime"><span>March 24, 2022</span></time>
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