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								<h1 class="AlignLeft objective-page-title">
									
<span>Research Priorities</span>

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            <div class="field field--name-field-introduction field--type-text-long field--label-hidden field__item"><p>The Compelling Questions (CQs) and Critical Challenges (CCs) submitted during the Visioning process were refined to yield a set of 132 Research Priorities that will guide the NHLBI for the next decade. NHLBI-solicited activities that result from the Research Priorities will advance our progress in achieving the eight Objectives and will have a profound effect on the health and well-being of people across this country and around the globe.</p>

<p>Investigator-initiated discovery science has been and will remain the bedrock of the NHLBI mission, and individual researchers will always be encouraged to pursue their ideas through investigator-initiated projects. However, NHLBI leadership can catalyze extramural investigations that take advantage of new scientific opportunities and close gaps in knowledge. One means by which this occurs is through Institute-solicited research initiatives supported through new Funding Opportunity Announcements (FOAs). The Research Priorities identify important opportunities in science that will shape the development of future FOAs and other NHLBI-solicited activities.</p></div>
      
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                <label for="edit-nhlbi-views-related-objective-80113--2" class="option"><span>1. Understand normal biological function and resilience</span></label>
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                <label for="edit-nhlbi-views-related-objective-80116--2" class="option"><span>4. Identify factors that account for individual differences in pathobiology and in responses to treatments</span></label>
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                <label for="edit-nhlbi-views-related-objective-80117--2" class="option"><span>5. Develop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseases</span></label>
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                <label for="edit-nhlbi-views-related-objective-80118--2" class="option"><span>6. Optimize clinical and implementation research to improve health and reduce disease</span></label>
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                <label for="edit-nhlbi-views-related-objective-80119--2" class="option"><span>7. Leverage emerging opportunities in data science to open new frontiers in HLBS research</span></label>
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                <label for="edit-nhlbi-views-related-objective-80120--2" class="option"><span>8. Further develop, diversify, and sustain a scientific workforce capable of accomplishing the NHLBI’s mission</span></label>
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                                                                                                    A better understanding of the factors governing the safety and efficacy of therapeutic hemoglobin-based extracellular oxygen carriers (HBOCs) and improved animal models for HBOC studies are needed. (5.CC.01)
                <div class="cc-cq-related-objective">Related Objective</div>
        
            <div class="field field--name-field-related-objective field--type-entity-reference field--label-hidden field__item"><a href="/about/strategic-vision/goals-and-objectives/develop-and-optimize-novel-diagnostic-and-therapeutic">5. 
<span>Develop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseases</span>
</a></div>
      
                                                        </div>
</article>
  </div>
    <div class="views-row">
    

<article class="standard-card node node--type-cc-or-cq node--view-mode-teaser">
                        <div class="flexItemText">
                                                                                <div class="cc-cq-category-label">
        
            <div class="field field--name-field-cc-or-cq field--type-list-string field--label-hidden field__item">Critical Challenge</div>
      
    </div>
                                                                                                    A new generation of ventricular assist devices is needed to minimize platelet activation, thrombogenesis, and bleeding; to incorporate better percutaneous and transcutaneous systems; and to improve battery and charging-mechanism designs. (5.CC.11)
                <div class="cc-cq-related-objective">Related Objective</div>
        
            <div class="field field--name-field-related-objective field--type-entity-reference field--label-hidden field__item"><a href="/about/strategic-vision/goals-and-objectives/develop-and-optimize-novel-diagnostic-and-therapeutic">5. 
<span>Develop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseases</span>
</a></div>
      
                                                        </div>
</article>
  </div>
    <div class="views-row">
    

<article class="standard-card node node--type-cc-or-cq node--view-mode-teaser">
                        <div class="flexItemText">
                                                                                <div class="cc-cq-category-label">
        
            <div class="field field--name-field-cc-or-cq field--type-list-string field--label-hidden field__item">Critical Challenge</div>
      
    </div>
                                                                                                    A variety of "smart" devices are needed that both monitor physiology and assist, adjust, or intervene automatically to treat acute complications of cardiovascular disease. (5.CC.10)
                <div class="cc-cq-related-objective">Related Objective</div>
        
            <div class="field field--name-field-related-objective field--type-entity-reference field--label-hidden field__item"><a href="/about/strategic-vision/goals-and-objectives/develop-and-optimize-novel-diagnostic-and-therapeutic">5. 
<span>Develop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseases</span>
</a></div>
      
                                                        </div>
</article>
  </div>
    <div class="views-row">
    

<article class="standard-card node node--type-cc-or-cq node--view-mode-teaser">
                        <div class="flexItemText">
                                                                                <div class="cc-cq-category-label">
        
            <div class="field field--name-field-cc-or-cq field--type-list-string field--label-hidden field__item">Critical Challenge</div>
      
    </div>
                                                                                                    Advancements are needed in the organization, infrastructure, integration, and availability of "omics" data, including genetic, epigenetic, transcriptomic, metabolomic, proteomic, phenotypic, and ontologic information. (7.CC.04)
                <div class="cc-cq-related-objective">Related Objective</div>
        
            <div class="field field--name-field-related-objective field--type-entity-reference field--label-hidden field__item"><a href="/about/strategic-vision/goals-and-objectives/leverage-emerging-opportunities-data-science-open-new">7. 
<span>Leverage emerging opportunities in data science to open new frontiers in HLBS research</span>
</a></div>
      
                                                        </div>
</article>
  </div>
    <div class="views-row">
    

<article class="standard-card node node--type-cc-or-cq node--view-mode-teaser">
                        <div class="flexItemText">
                                                                                <div class="cc-cq-category-label">
        
            <div class="field field--name-field-cc-or-cq field--type-list-string field--label-hidden field__item">Critical Challenge</div>
      
    </div>
                                                                                                    Advances in methods of and models for assessing and characterizing exposures (e.g., diet, smoking, other environmental and social exposures) are needed to understand differences in health among populations. (3.CC.04)
                <div class="cc-cq-related-objective">Related Objective</div>
        
            <div class="field field--name-field-related-objective field--type-entity-reference field--label-hidden field__item"><a href="/about/strategic-vision/goals-and-objectives/investigate-factors-account-differences-health-among">3. 
<span>Investigate factors that account for differences in health among populations</span>
</a></div>
      
                                                        </div>
</article>
  </div>
    <div class="views-row">
    

<article class="standard-card node node--type-cc-or-cq node--view-mode-teaser">
                        <div class="flexItemText">
                                                                                <div class="cc-cq-category-label">
        
            <div class="field field--name-field-cc-or-cq field--type-list-string field--label-hidden field__item">Critical Challenge</div>
      
    </div>
                                                                                                    Advances in methods of and models for assessing and characterizing exposures (e.g., environmental, dietary, social) are needed to improve research on normal biologic function and resilience. (1.CC.04)
                <div class="cc-cq-related-objective">Related Objective</div>
        
            <div class="field field--name-field-related-objective field--type-entity-reference field--label-hidden field__item"><a href="/about/strategic-vision/goals-and-objectives/understand-normal-biological-function-and-resilience">1. 
<span>Understand normal biological function and resilience</span>
</a></div>
      
                                                        </div>
</article>
  </div>
    <div class="views-row">
    

<article class="standard-card node node--type-cc-or-cq node--view-mode-teaser">
                        <div class="flexItemText">
                                                                                <div class="cc-cq-category-label">
        
            <div class="field field--name-field-cc-or-cq field--type-list-string field--label-hidden field__item">Critical Challenge</div>
      
    </div>
                                                                                                    An understanding of the immune system from a systems biology perspective is needed to design more efficacious treatment strategies for chronic inflammatory and autoimmune HLBS diseases. (5.CC.02)
                <div class="cc-cq-related-objective">Related Objective</div>
        
            <div class="field field--name-field-related-objective field--type-entity-reference field--label-hidden field__item"><a href="/about/strategic-vision/goals-and-objectives/develop-and-optimize-novel-diagnostic-and-therapeutic">5. 
<span>Develop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseases</span>
</a></div>
      
                                                        </div>
</article>
  </div>
    <div class="views-row">
    

<article class="standard-card node node--type-cc-or-cq node--view-mode-teaser">
                        <div class="flexItemText">
                                                                                <div class="cc-cq-category-label">
        
            <div class="field field--name-field-cc-or-cq field--type-list-string field--label-hidden field__item">Critical Challenge</div>
      
    </div>
                                                                                                    Better apheresis-based sickle cell disease treatments are needed to provide the benefits of blood transfusion without the risks and complications that are associated with both simple and exchange transfusions. (5.CC.09)
                <div class="cc-cq-related-objective">Related Objective</div>
        
            <div class="field field--name-field-related-objective field--type-entity-reference field--label-hidden field__item"><a href="/about/strategic-vision/goals-and-objectives/develop-and-optimize-novel-diagnostic-and-therapeutic">5. 
<span>Develop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseases</span>
</a></div>
      
                                                        </div>
</article>
  </div>
    <div class="views-row">
    

<article class="standard-card node node--type-cc-or-cq node--view-mode-teaser">
                        <div class="flexItemText">
                                                                                <div class="cc-cq-category-label">
        
            <div class="field field--name-field-cc-or-cq field--type-list-string field--label-hidden field__item">Critical Challenge</div>
      
    </div>
                                                                                                    Better preparation of scientists for transitions between career stages (e.g., the graduate/medical education stage, the postdoctoral/fellowship period, the junior investigator stage) is needed. (8.CC.05)
                <div class="cc-cq-related-objective">Related Objective</div>
        
            <div class="field field--name-field-related-objective field--type-entity-reference field--label-hidden field__item"><a href="/about/strategic-vision/goals-and-objectives/further-develop-diversify-and-sustain-scientific">8. 
<span>Further develop, diversify, and sustain a scientific workforce capable of accomplishing the NHLBI’s mission</span>
</a></div>
      
                                                        </div>
</article>
  </div>
    <div class="views-row">
    

<article class="standard-card node node--type-cc-or-cq node--view-mode-teaser">
                        <div class="flexItemText">
                                                                                <div class="cc-cq-category-label">
        
            <div class="field field--name-field-cc-or-cq field--type-list-string field--label-hidden field__item">Critical Challenge</div>
      
    </div>
                                                                                                    Bold new bioinformatic and biostatistical methods and approaches are needed to improve the analysis of big data. (7.CC.05)
                <div class="cc-cq-related-objective">Related Objective</div>
        
            <div class="field field--name-field-related-objective field--type-entity-reference field--label-hidden field__item"><a href="/about/strategic-vision/goals-and-objectives/leverage-emerging-opportunities-data-science-open-new">7. 
<span>Leverage emerging opportunities in data science to open new frontiers in HLBS research</span>
</a></div>
      
                                                        </div>
</article>
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