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<article class="node node--type-science node--science-theme--blue node--view-mode-full">

  
    

  
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      <div class="responsive-container responsive-container-constrained breadcrumbs-container"><div class="breadcrumbs"><ul> <li class='breadcrumb-home'><a href='/'>Home</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-parent'><a href='/node/80002'><span class='back-to'> < Back To </span>The Science</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-current'>Pulmonary Vascular Biology Laboratory</li></ul></div></div>
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      <h1>Pulmonary Vascular Biology Laboratory</h1>
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            <div class="field field--name-field-component-lab-banner-descr field--type-text-long field--label-hidden field__item"><p>The focus of the Pulmonary Vascular Biology Lab, led by Dr. Jason Elinoff, is the interplay between lung vascular endothelium and immune effector cells and their contributions to the development and progression of pulmonary arterial hypertension (PAH).</p></div>
      
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<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="200" height="200" alt="Jason Elinoff, M.D." data-src="/sites/default/files/styles/square_image/public/2023-06/jason_elinoff.jpg?itok=5ZO7ZVer" class="b-lazy image-style-square-image" />


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<span>Jason Elinoff, M.D.</span>

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            <div class="field field--name-field-employment-title field--type-string field--label-hidden field__item">Tenure Track Investigator</div>
      
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                  <h2 class="component-title">Senior Investigator Research Interests</h2>
            
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    <div class="field__label">Research Interests</div>
              <div class="field__item"><p>Pulmonary arterial hypertension (PAH) is characterized by dysregulated cell proliferation and infiltration of activated inflammatory cells leading to progressive narrowing and obliteration of the distal pulmonary arteries. While current therapeutics reduce pulmonary arterial pressure and increase time to death or transplant, median survival remains only 5-7 years from diagnosis. Unlike selective pulmonary vasodilators alone, approaches directed at inflammatory vascular remodeling have the potential to arrest or even reverse the disease. The focus of the Pulmonary Vascular Biology Lab, led by Dr. Jason Elinoff, is the interplay between lung vascular endothelium and immune effector cells and their contributions to the development and progression of PAH. Current work includes in vitro profiling of human pulmonary artery endothelial cells with heterogeneous PAH-associated molecular defects in order to investigate molecular mechanisms that can exploited therapeutically. The overarching goal of the program is to translate basic science and pre-clinical studies to early phase therapeutic trials in PAH patients.</p></div>
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Mineralocorticoid receptor antagonist treatment of established pulmonary arterial hypertension improves interventricular dependence in the SU5416-hypoxia rat model.</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Lu M, Chen LY, Gairhe S, Mazer AJ, Anderson SA, Nelson JNH, Noguchi A, Siddique MAS, Dougherty EJ, Zou Y, Johnston KA, Yu ZX, Wang H, Wang S, Sun J, Solomon SB, Vanderpool RR, Solomon MA, Danner RL, Elinoff JM.
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            <span>
            Am J Physiol Lung Cell Mol Physiol
      
                2022 Mar 01</span>;322(3):L315-L332
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                                                    <a href="https://pubmed.ncbi.nlm.nih.gov/35043674/" aria-label="Mineralocorticoid receptor antagonist treatment of established pulmonary arterial hypertension improves interventricular dependence in the SU5416-hypoxia rat model." class="read-publications">Read Publication</a>
                            
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Type I Interferon Activation and Endothelial Dysfunction in Caveolin-1 Insufficiency-associated Pulmonary Arterial Hypertension.</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>2.	Gairhe S, Awad KS, Dougherty EJ, Ferreyra GA, Wang S, Yu ZX, Takeda K, Demirkale CY, Torabi-Parizi P, Austin ED, Elinoff JM, Danner RL.
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            <span>
            Proc Natl Acad Sci USA.
      
                2021 Mar 16</span>;118(11):
        </div>
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                                                    <a href="https://pubmed.ncbi.nlm.nih.gov/33836561/" aria-label="Type I Interferon Activation and Endothelial Dysfunction in Caveolin-1 Insufficiency-associated Pulmonary Arterial Hypertension." class="read-publications">Read Publication</a>
                            
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            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Meta-analysis of blood genome-wide expression profiling studies in pulmonary arterial hypertension.</div>
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               <span>Authors: </span>3.	Elinoff JM, Mazer AJ, Cai R, Lu M, Graninger G, Harper B, Ferreyra GA, Sun J, Solomon MA, Danner RL.
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            <span>
            Am J Physiol Lung Cell Mol Physiol.
      
                2020 Jan 01</span>;318(1):L98-L111.
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                                                    <a href="https://pubmed.ncbi.nlm.nih.gov/31617731/" aria-label="Meta-analysis of blood genome-wide expression profiling studies in pulmonary arterial hypertension." class="read-publications">Read Publication</a>
                            
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg.</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Elinoff JM, Agarwal R, Barnett CF, Benza RL, Rosenzweig EB, Cuttica MJ, Gharib AM, Gray MP, Hassoun PM, Hemnes AR, Humbert M, Kolb TM, Lahm T, Leopold JA, Mathai SC, McLaughlin VV, Preston IR, Shlobin OA, Steen VD, Zamanian RT, Solomon MA.
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            <span>
            Am J Respir Crit Care Med.
      
                2018 Jul 15</span>;198(2):166-174
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                                                    <a href="https://pubmed.ncbi.nlm.nih.gov/29425462/" aria-label="Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg." class="read-publications">Read Publication</a>
                            
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                                                    <h3>
            <div class="field field--name-field-publication-title field--type-string-long field--label-hidden field__item">Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-κB and AP-1 signalling</div>
      </h3>
            <div class="publicationAuthors">
               <span>Authors: </span>Elinoff JM, Chen LY, Dougherty EJ, Awad KS, Wang S, Biancotto A, Siddiqui AH, Weir NA, Cai R, Sun J, Preston IR, Solomon MA, Danner RL
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            <span>
            Cardiovasc Res.
      
                2018 Jan 01</span>;114(1):65-76
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                                                    <a href="https://pubmed.ncbi.nlm.nih.gov/29036418/" aria-label="Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-κB and AP-1 signalling" class="read-publications">Read Publication</a>
                            
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<img loading="lazy" src="/modules/custom/nhlbi_blazy/images/clear.png" width="250" height="250" alt="Jason Elinoff, M.D." data-src="/sites/default/files/styles/square_image_250x250/public/2023-06/jason_elinoff.jpg?itok=foCRdk_t" class="b-lazy image-style-square-image-250x250" />


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                    Jason Elinoff, M.D.
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            <div class="clearfix text-formatted field field--name-field-person-bio field--type-text-with-summary field--label-hidden field__item"><p>Dr. Elinoff earned his undergraduate degree in Chemistry from Princeton University and his degree in Medicine from the University of Chicago Pritzker School of Medicine. He went on to complete internship and residency training in Internal Medicine at the Massachusetts General Hospital. Dr. Elinoff completed his fellowship training in Critical Care Medicine at the NIH Clinical Center and Pulmonary and Critical Care Medicine at Johns Hopkins University.</p></div>
      
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