<!DOCTYPE html>
<html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#">
  <head>
    <meta charset="utf-8" />
<link rel="canonical" href="https://www.nhlbi.nih.gov/science/vascular-interventionsinnovations-and-therapeutic-advances-vita-program" />
<link rel="image_src" href="https://www.nhlbi.nih.gov/themes/custom/nhlbi/images/NHLBI_Meta_Image.png" />
<meta name="referrer" content="no-referrer-when-downgrade" />
<meta property="og:site_name" content="NHLBI, NIH" />
<meta property="og:title" content="Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program" />
<meta property="og:image" content="https://www.nhlbi.nih.gov/themes/custom/nhlbi/images/NHLBI_Meta_Image.png" />
<meta name="twitter:card" content="summary_large_image" />
<meta name="twitter:site" content="@nih_nhlbi" />
<meta name="twitter:title" content="Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program | NHLBI, NIH" />
<meta name="twitter:image" content="https://www.nhlbi.nih.gov/themes/custom/nhlbi/images/NHLBI_Meta_Image.png" />
<meta name="Generator" content="Drupal 10 (https://www.drupal.org)" />
<meta name="MobileOptimized" content="width" />
<meta name="HandheldFriendly" content="true" />
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
<link rel="preconnect" href="//use.fontawesome.com" />
<link rel="preconnect" href="//fonts.googleapis.com" />
<link rel="preconnect" href="//themes.googleusercontent.com" />
<link rel="preconnect" href="https://static.addtoany.com" />
<link rel="preconnect" href="https://www.google-analytics.com" />
<link rel="preconnect" href="https://dap.digitalgov.gov" />
<link rel="preconnect" href="https://assets.adobedtm.com" />
<meta name="keywords" content="VITA Program,Translational Research,NHLBI research,NHLBI clinical trials,Pre-Clinical,Scientific Discovery,Product Development,Vascular Disorders,Thrombotic Diseases,Pulmonary Hypertension" />
<meta name="description" content="Learn how the NHLBI’s Vascular Interventions/Innovations and Therapeutic Advances (VITA) program supports pre-clinical translational development of product candidates in the fields of vascular disorders, thrombotic diseases, and pulmonary hypertension." />
<link rel="icon" href="/themes/custom/nhlbi/favicon.ico" type="image/vnd.microsoft.icon" />
<link rel="alternate" hreflang="en" href="https://www.nhlbi.nih.gov/science/vascular-interventionsinnovations-and-therapeutic-advances-vita-program" />
<script>window.a2a_config=window.a2a_config||{};a2a_config.callbacks=[];a2a_config.overlays=[];a2a_config.templates={};a2a_config.onclick = 1;
a2a_config.num_services = 4;
a2a_config.prioritize = [ 'facebook', 'twitter', 'linkedin', 'copy_link', ];
</script>
<style>.a2apage_wide.a2a_wide{display:none;}
.a2a_menu.a2a_full{display:none !important;}
#a2a_overlay{display:none !important;}
.addtoany_share span{background-color: #0051a8 !important;}
.a2a_button_email span{background-color: #0051a8 !important;}
.a2a_button_print span{background-color: #0051a8 !important;}
.a2a_s_link {background-color: #0051a8 !important;}</style>

    <title>Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program | NHLBI, NIH</title>
    <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/core.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/controlgroup.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/checkboxradio.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/resizable.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/button.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/dialog.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/ajax-progress.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/align.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/autocomplete-loading.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/fieldgroup.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/container-inline.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/clearfix.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/details.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/hidden.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/item-list.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/js.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/nowrap.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/position-container.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/progress.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/reset-appearance.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/resize.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/sticky-header.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-counter.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-counters.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-general-info.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/tabledrag.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/tablesort.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/system/css/components/tree-child.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/modules/custom/nhlbi_ckeditor/css/nhlbi_ckeditor.css?sb60d1" />
<link rel="stylesheet" media="all" href="/modules/contrib/blazy/css/blazy.css?sb60d1" />
<link rel="stylesheet" media="all" href="/modules/contrib/blazy/css/components/blazy.loading.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/views/css/views.module.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/ckeditor5/css/ckeditor5.dialog.fix.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/theme.css?sb60d1" />
<link rel="stylesheet" media="all" href="/modules/contrib/addtoany/css/addtoany.css?sb60d1" />
<link rel="stylesheet" media="all" href="/libraries/fontawesome/css/fontawesome.min.css?sb60d1" />
<link rel="stylesheet" media="all" href="/libraries/fontawesome/css/solid.min.css?sb60d1" />
<link rel="stylesheet" media="all" href="/libraries/fontawesome/css/regular.min.css?sb60d1" />
<link rel="stylesheet" media="all" href="/libraries/fontawesome/css/light.min.css?sb60d1" />
<link rel="stylesheet" media="all" href="/libraries/fontawesome/css/brands.min.css?sb60d1" />
<link rel="stylesheet" media="all" href="/libraries/fontawesome/css/thin.min.css?sb60d1" />
<link rel="stylesheet" media="all" href="/libraries/fontawesome/css/sharp-regular.min.css?sb60d1" />
<link rel="stylesheet" media="all" href="/libraries/fontawesome/css/sharp-light.min.css?sb60d1" />
<link rel="stylesheet" media="all" href="/libraries/fontawesome/css/sharp-solid.min.css?sb60d1" />
<link rel="stylesheet" media="all" href="/libraries/fontawesome/css/custom-icons.min.css?sb60d1" />
<link rel="stylesheet" media="all" href="/modules/custom/nih_extlink/nih_extlink.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/layout_discovery/layouts/onecol/onecol.css?sb60d1" />
<link rel="stylesheet" media="all" href="/core/modules/layout_builder/layouts/threecol_section/threecol_section.css?sb60d1" />
<link rel="stylesheet" media="all" href="/modules/contrib/paragraphs/css/paragraphs.unpublished.css?sb60d1" />
<link rel="stylesheet" media="all" href="/themes/contrib/classy/css/components/node.css?sb60d1" />
<link rel="stylesheet" media="all" href="/themes/custom/nhlbi/assets/uswds/dist/css/uswds.min.css?sb60d1" />
<link rel="stylesheet" media="all" href="/themes/custom/nhlbi/css/styles.css?sb60d1" />
<link rel="stylesheet" media="all" href="/themes/custom/nhlbi/css/components.css?sb60d1" />
<link rel="stylesheet" media="print" href="/themes/custom/nhlbi/css/print.css?sb60d1" />
<link rel="stylesheet" media="all" href="/themes/custom/nhlbi/css/jquery-ui.min.css?sb60d1" />

    <script src="https://script.crazyegg.com/pages/scripts/0098/3175.js" async></script>
<script src="//assets.adobedtm.com/073614e3197b/44904e2aeeca/launch-f5509bc9803f.min.js" async></script>

    <meta http-equiv="X-UA-Compatible" content="IE=edge" />
    <link rel="apple-touch-icon" sizes="76x76" href="/themes/custom/nhlbi/images/icons/touch-icon-ipad.png">
    <link rel="apple-touch-icon" sizes="120x120" href="/themes/custom/nhlbi/images/icons/touch-icon-iphone-retina.png">
    <link rel="apple-touch-icon" sizes="152x152" href="/themes/custom/nhlbi/images/icons/touch-icon-ipad-retina.png">
    <link href="https://fonts.googleapis.com/css2?family=Merriweather:ital,wght@0,400;0,700;1,400;1,700&display=swap" rel="stylesheet">
    <link href="https://fonts.googleapis.com/css2?family=Open+Sans:ital,wght@0,400;0,600;0,700;1,400;1,600;1,700&display=swap" rel="stylesheet">

    <script type="text/javascript">
      // Instructions: please embed this snippet directly into every page in your website template.
      // For optimal performance, this must be embedded directly into the template, not referenced
      // as an external file.

      // Verint Production Embed Script v2.01
      // DO NOT MODIFY BELOW THIS LINE *****************************************
      ;(function (g) {
        var d = document, am = d.createElement('script'), h = d.head || d.getElementsByTagName("head")[0], fsr = 'fsReady',
        aex = {
          "src": "//eex-gateway.fr011.ttecfed.com/sites/nhlbi-gov/production/gateway.min.js",
          "type": "text/javascript",
          "async": "true",
          "data-vendor": "fs",
          "data-role": "gateway"
        };
        for (var attr in aex) { am.setAttribute(attr, aex[attr]); } h.appendChild(am); g[fsr] || (g[fsr] = function () { var aT = '__' + fsr + '_stk__'; g[aT] = g[aT] || []; g[aT].push(arguments); });
      })(window);
      // DO NOT MODIFY ABOVE THIS LINE *****************************************

      // Un-comment out the function below when you are ready to input your variable
      fsReady(function() {
        const currentURL = window.location.href;
        FSR.CPPS.set("url", currentURL);
      });
    </script>
  </head>

  <body class="science-vascular-interventionsinnovations-and-therapeutic-advances-vita-program path-node node--type-extramural-science-instance">
    <a href="#main-content" class="visually-hidden focusable skip-link">
        Skip to main content
    </a>

    
      <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
    <div class="layout-container">

  <header role="banner" id="header" class="header row">
      <div class="region region-header">
    <div id="block-uswdsbanner" class="block block-block-content block-block-content481480b7-71a2-4bd6-aebd-bab5f19db932">
  
    
      
            <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><section aria-label="Official government website" class="usa-banner"><div class="usa-accordion">
<div class="usa-banner__header">
<div class="usa-banner__inner">
<div class="grid-col-auto"><img alt="U.S. flag" class="usa-banner__header-flag b-lazy" height="auto" width="auto" data-src="/themes/custom/nhlbi/assets/uswds/dist/img/us_flag_small.png" src="/modules/custom/nhlbi_blazy/images/clear.png" /></div>

<div class="grid-col-fill tablet:grid-col-auto">
<p class="usa-banner__header-text">An official website of the United States government</p>

<p aria-hidden="true" class="usa-banner__header-action">Here’s how you know</p>
</div>
<button aria-controls="gov-banner-default-default" aria-expanded="false" class="usa-accordion__button usa-banner__button" type="button"><span class="usa-banner__button-text">Here’s how you know</span></button></div>
</div>

<div class="usa-banner__content usa-accordion__content" id="gov-banner-default-default">
<div class="grid-row grid-gap-lg">
<div class="usa-banner__guidance tablet:grid-col-6"><img alt="" aria-hidden="true" class="usa-banner__icon usa-media-block__img b-lazy" role="img" height="auto" width="auto" data-src="/themes/custom/nhlbi/assets/uswds/dist/img/icon-dot-gov.svg" src="/modules/custom/nhlbi_blazy/images/clear.png" /><div class="usa-media-block__body">
<p><strong>Official websites use .gov</strong><br />
A <strong>.gov</strong> website belongs to an official government organization in the United States.</p>
</div>
</div>

<div class="usa-banner__guidance tablet:grid-col-6"><img alt="" aria-hidden="true" class="usa-banner__icon usa-media-block__img b-lazy" role="img" height="auto" width="auto" data-src="/themes/custom/nhlbi/assets/uswds/dist/img/icon-https.svg" src="/modules/custom/nhlbi_blazy/images/clear.png" /><div class="usa-media-block__body">
<p><strong>Secure .gov websites use HTTPS</strong><br />
A <strong>lock</strong> ( <span class="icon-lock"><svg aria-labelledby="banner-lock-title-default banner-lock-description-default" class="usa-banner__lock-image" focusable="false" height="64" role="img" viewbox="0 0 52 64" width="52" xmlns="http://www.w3.org/2000/svg"><title id="banner-lock-title-default"></title><desc id="banner-lock-description-default">A locked padlock</desc><path d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z" fill="#000000" fill-rule="evenodd"></path></svg></span>) or <strong>https://</strong> means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.</p>
</div>
</div>
</div>
</div>
</div>
</section></div>
      
  </div>
<div id="block-sitebranding-2" class="block block-system block-system-branding-block">
  
    
  	<script type="text/javascript">
		function toggleMainNavigationMenu(){
			jQuery('#main-menu-header-no-desktop ul.menu').toggle();
		};
	</script>

	
	<div id="block-mainnavigation" class="block block-system block-system-menu-blockmain">
      

<div id="main-menu-container">
	<div class="responsive-container responsive-container-constrained">
		<div id="main-menu-header">
			<div id="main-site-top">
				<div id="main-site-logo">
					<a aria-label="home" href="/">
						<img class="b-lazy" data-src="/themes/custom/nhlbi/images/NHLBI-logo-75-year.svg" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" alt="National Heart, Lung, and Blood Home"/>
					</a>
				</div>
				<div id="header-searchbox" class="last">


					<div class="global-search-bar" id="global-search-bar-tablet-desktop">
						<form action="/site-search" method="GET">
							<label for="searchQueryText_tablet_desktop" class="visually-hidden">
								<span>
									Search Query:
								</span>
							</label>
							<input id="searchQueryText_tablet_desktop" type="text" name="searchtext" placeholder="Search the NHLBI" autocomplete="off">
							<input type="submit" class="submit-button" aria-label="Global Search Desktop" label="Global Search Button">
						</form>
					</div>
				</div>
			</div>
			<div id="main-navbar">
				<div id="publication-shopping-cart"></div>
				<div id="searchBoxIconInner" tabindex="0" role="search"></div>
				<div class="hamburger-nav-icon-box">
					<div id="hamburger-nav-icon"></div>
				</div>
														<ul class="menu-level-0" role="menu" aria-label="main menu">
						<div class="active menu-item-link-main menu-item-link menu-item--active-trail expand-vertical hidden">
							<span class="level-0-link" id="main-menu-item-main-button" tabindex="0">
								<a>
									MAIN MENU
								</a>
							</span>
						</div>

																				
              <li  class="menu-item-link expand-horizontal fa-light fa-user-doctor menu-style-2-level"   class="menu-item-link expand-horizontal fa-light fa-user-doctor menu-style-2-level" id="main-menu-item-health-topics"   role="menuitem">
                <span class="level-0-link"  class="menu-item-link expand-horizontal fa-light fa-user-doctor menu-style-2-level" id="main-menu-item-health-topics-inner" tabindex="0" role="button">
                  Health Topics
                </span>
								<div class="main-menu-children-wrapper" tab>
									<div class="level1-menu-wrapper hidden expand-horizontal fa-light fa-user-doctor menu-style-2-level" id="main-menu-item-health-topics_children">
																				
												
		

		<ul class="menu-level-1">

															<li class="highlighted"  >
											<a href="/health" role="menuitem" data-drupal-link-system-path="node/93751">All Health Topics A-Z</a>
					
													
		

		<ul class="menu-level-2">

															<li  >
											<a href="/health/asthma" role="menuitem" data-drupal-link-system-path="node/92783">Asthma</a>
					
									</li>


				

															<li  >
											<a href="/health/heart-healthy-living" role="menuitem" data-drupal-link-system-path="node/93169">Heart-Healthy Living</a>
					
									</li>


				

															<li  >
											<a href="/health/high-blood-pressure" role="menuitem" data-drupal-link-system-path="node/93173">High Blood Pressure</a>
					
									</li>


				

															<li  >
											<a href="/health/sickle-cell-disease" role="menuitem" data-drupal-link-system-path="node/92844">Sickle Cell Disease</a>
					
									</li>


				

															<li  >
											<a href="/health/sleep-apnea" role="menuitem" data-drupal-link-system-path="node/93139">Sleep Apnea</a>
					
									</li>


				

					</ul>
	
									</li>


				

															<li class="highlighted"  >
											<a href="/covid" role="menuitem" data-drupal-link-system-path="node/89977">Information & Resources on COVID-19</a>
					
									</li>


				

					</ul>
	
									</div>
								</div>
							</li>
																				
              <li  class="menu-item-link expand-vertical fa-light fa-book menu-style-2-level"   class="menu-item-link expand-vertical fa-light fa-book menu-style-2-level" id="main-menu-item-resources"   role="menuitem">
                <span class="level-0-link"  class="menu-item-link expand-vertical fa-light fa-book menu-style-2-level" id="main-menu-item-resources-inner" tabindex="0" role="button">
                  Health Education
                </span>
								<div class="main-menu-children-wrapper" tab>
									<div class="level1-menu-wrapper hidden expand-vertical fa-light fa-book menu-style-2-level" id="main-menu-item-resources_children">
																				
												
		

		<ul class="menu-level-1">

															<li class="highlighted"  >
											<a href="/education" role="menuitem" data-drupal-link-system-path="node/80460">Education Programs and Initiatives</a>
					
													
		

		<ul class="menu-level-2">

															<li  >
											<a href="/health-topics/education-and-awareness/heart-truth" role="menuitem" data-drupal-link-system-path="node/86712">The Heart Truth®</a>
					
									</li>


				

															<li  >
											<a href="/BreatheBetter" role="menuitem" data-drupal-link-system-path="node/87500">Learn More Breathe Better®</a>
					
									</li>


				

															<li  >
											<a href="/education/blood" role="menuitem" data-drupal-link-system-path="node/91892">Blood Diseases and Disorders Education Program</a>
					
									</li>


				

					</ul>
	
									</li>


				

															<li class="highlighted"  >
											<a href="/resources?f%5B0%5D=language%3AEnglish" role="menuitem" data-drupal-link-query="{"f":["language:English"]}" data-drupal-link-system-path="node/127707">Publications and Resources</a>
					
									</li>


				

					</ul>
	
									</div>
								</div>
							</li>
																				
              <li  class="menu-item-link menu-item--active-trail expand-vertical fa-light fa-vial menu-style-split menu-style-final-link menu-style-1-level-heading"   class="menu-item-link menu-item--active-trail expand-vertical fa-light fa-vial menu-style-split menu-style-final-link menu-style-1-level-heading" id="main-menu-item-the-science"   role="menuitem">
                <span class="level-0-link"  class="menu-item-link menu-item--active-trail expand-vertical fa-light fa-vial menu-style-split menu-style-final-link menu-style-1-level-heading" id="main-menu-item-the-science-inner" tabindex="0" role="button">
                  The Science
                </span>
								<div class="main-menu-children-wrapper" tab>
									<div class="level1-menu-wrapper hidden expand-vertical fa-light fa-vial menu-style-split menu-style-final-link menu-style-1-level-heading" id="main-menu-item-the-science_children">
																				
												
		

		<ul class="menu-level-1">

															<li class="highlighted"  >
											<a href="/science" role="menuitem" data-drupal-link-system-path="node/80002">Research Focus Areas</a>
					
													
		

		<ul class="menu-level-2">

															<li  >
											<a href="/science/blood-disorders-and-blood-safety" role="menuitem" data-drupal-link-system-path="node/80037">Blood Disorders and Blood Safety</a>
					
									</li>


				

															<li  >
											<a href="/science/sleep-science-and-sleep-disorders" role="menuitem" data-drupal-link-system-path="node/80038">Sleep Science and Sleep Disorders</a>
					
									</li>


				

															<li  >
											<a href="/science/lung-diseases" role="menuitem" data-drupal-link-system-path="node/80039">Lung Diseases</a>
					
									</li>


				

															<li  >
											<a href="/science/health-disparities-and-inequities" role="menuitem" data-drupal-link-system-path="node/80046">Health Disparities and Inequities</a>
					
									</li>


				

															<li  >
											<a href="/science/heart-and-vascular-diseases" role="menuitem" data-drupal-link-system-path="node/80040">Heart and Vascular Diseases</a>
					
									</li>


				

															<li  >
											<a href="/science/precision-medicine-activities" role="menuitem" data-drupal-link-system-path="node/80042">Precision Medicine Activities</a>
					
									</li>


				

															<li  >
											<a href="/science/obesity-nutrition-and-physical-activity" role="menuitem" data-drupal-link-system-path="node/80041">Obesity, Nutrition, and Physical Activity</a>
					
									</li>


				

															<li  >
											<a href="/science/population-and-epidemiology-studies" role="menuitem" data-drupal-link-system-path="node/80043">Population and Epidemiology Studies</a>
					
									</li>


				

															<li  >
											<a href="/science/womens-health" role="menuitem" data-drupal-link-system-path="node/80044">Women’s Health</a>
					
									</li>


				

					</ul>
	
									</li>


				

															<li  >
											<a href="/research/research-topics" role="menuitem" data-drupal-link-system-path="node/129758">Research Topics</a>
					
									</li>


				

															<li  >
											<a href="/research/clinical-trials" role="menuitem" data-drupal-link-system-path="node/93754">Clinical Trials</a>
					
									</li>


				

															<li class="highlighted highlighted-button"  >
											<a href="/science/all-science" role="menuitem" data-drupal-link-system-path="node/83134">All Science A-Z</a>
					
									</li>


				

					</ul>
	
									</div>
								</div>
							</li>
																				
              <li  class="menu-item-link expand-horizontal fa-light fa-square-list menu-style-1-level"   class="menu-item-link expand-horizontal fa-light fa-square-list menu-style-1-level" id="main-menu-item-grants-and-training"   role="menuitem">
                <span class="level-0-link"  class="menu-item-link expand-horizontal fa-light fa-square-list menu-style-1-level" id="main-menu-item-grants-and-training-inner" tabindex="0" role="button">
                  Grants and Training
                </span>
								<div class="main-menu-children-wrapper" tab>
									<div class="level1-menu-wrapper hidden expand-horizontal fa-light fa-square-list menu-style-1-level" id="main-menu-item-grants-and-training_children">
																				
												
		

		<ul class="menu-level-1">

															<li  >
											<a href="/grants-and-training" role="menuitem" data-drupal-link-system-path="node/80073">Grants and Training Home</a>
					
									</li>


				

															<li  >
											<a href="/grants-and-training/policies-procedures-and-guidelines" role="menuitem" data-drupal-link-system-path="node/80570">Policies and Guidelines</a>
					
									</li>


				

															<li  >
											<a href="/grants-and-training/funding-opportunities-and-contacts" role="menuitem" data-drupal-link-system-path="node/80466">Funding Opportunities and Contacts</a>
					
									</li>


				

															<li  >
											<a href="/grants-and-training/training-and-career-development" role="menuitem" data-drupal-link-system-path="node/80462">Training and Career Development</a>
					
									</li>


				

					</ul>
	
									</div>
								</div>
							</li>
																				
              <li  class="menu-item-link expand-horizontal fa-light fa-newspaper menu-style-2-level"   class="menu-item-link expand-horizontal fa-light fa-newspaper menu-style-2-level" id="main-menu-item-news-and-items"   role="menuitem">
                <span class="level-0-link"  class="menu-item-link expand-horizontal fa-light fa-newspaper menu-style-2-level" id="main-menu-item-news-and-items-inner" tabindex="0" role="button">
                  News and Events
                </span>
								<div class="main-menu-children-wrapper" tab>
									<div class="level1-menu-wrapper hidden expand-horizontal fa-light fa-newspaper menu-style-2-level" id="main-menu-item-news-and-items_children">
																				
												
		

		<ul class="menu-level-1">

															<li class="highlighted"  >
											<a href="/news-and-events" role="menuitem" data-drupal-link-system-path="node/80001">News and Events Home</a>
					
													
		

		<ul class="menu-level-2">

															<li  >
											<a href="/news-and-events/email-alerts" role="menuitem" data-drupal-link-system-path="node/80442">Email Alerts</a>
					
									</li>


				

					</ul>
	
									</li>


				

															<li class="highlighted"  >
											<a href="/news" role="menuitem" data-drupal-link-system-path="node/83132">All News</a>
					
													
		

		<ul class="menu-level-2">

															<li  >
											<a href="/news?news_type=press_release" role="menuitem" data-drupal-link-query="{"news_type":"press_release"}" data-drupal-link-system-path="node/83132"> NHLBI News</a>
					
									</li>


				

															<li  >
											<a href="/news?news_type=news_mention" role="menuitem" data-drupal-link-query="{"news_type":"news_mention"}" data-drupal-link-system-path="node/83132">NHLBI in the Press</a>
					
									</li>


				

															<li  >
											<a href="/news?news_type=feature_article" role="menuitem" data-drupal-link-query="{"news_type":"feature_article"}" data-drupal-link-system-path="node/83132">Research Features</a>
					
									</li>


				

					</ul>
	
									</li>


				

															<li class="highlighted"  >
											<a href="/events" role="menuitem" data-drupal-link-system-path="node/83133">All Events</a>
					
													
		

		<ul class="menu-level-2">

															<li  >
											<a href="/events?field_event_date_custom=Past%20Only" role="menuitem" data-drupal-link-query="{"field_event_date_custom":"Past Only"}" data-drupal-link-system-path="node/83133">Past Events</a>
					
									</li>


				

															<li  >
											<a href="/events?field_event_date_custom=Upcoming%20Only" role="menuitem" data-drupal-link-query="{"field_event_date_custom":"Upcoming Only"}" data-drupal-link-system-path="node/83133">Upcoming Events </a>
					
									</li>


				

					</ul>
	
									</li>


				

					</ul>
	
									</div>
								</div>
							</li>
																				
              <li  class="menu-item-link expand-vertical fa-light fa-circle-info menu-style-split menu-style-1-level-heading menu-style-1-level menu-style-align-right"   class="menu-item-link expand-vertical fa-light fa-circle-info menu-style-split menu-style-1-level-heading menu-style-1-level menu-style-align-right" id="main-menu-item-about-nhlbi"   role="menuitem">
                <span class="level-0-link"  class="menu-item-link expand-vertical fa-light fa-circle-info menu-style-split menu-style-1-level-heading menu-style-1-level menu-style-align-right" id="main-menu-item-about-nhlbi-inner" tabindex="0" role="button">
                  About NHLBI
                </span>
								<div class="main-menu-children-wrapper" tab>
									<div class="level1-menu-wrapper hidden expand-vertical fa-light fa-circle-info menu-style-split menu-style-1-level-heading menu-style-1-level menu-style-align-right" id="main-menu-item-about-nhlbi_children">
																				
												
		

		<ul class="menu-level-1">

															<li class="highlighted"  >
											<a href="/about" role="menuitem" data-drupal-link-system-path="node/80068">About NHLBI Home</a>
					
													
		

		<ul class="menu-level-2">

															<li  >
											<a href="/about/strategic-vision" role="menuitem" data-drupal-link-system-path="node/80111">Mission and Strategic Vision</a>
					
									</li>


				

															<li  >
											<a href="/about/leadership" role="menuitem" data-drupal-link-system-path="node/80312">Leadership</a>
					
									</li>


				

															<li  >
											<a href="/about/divisions" role="menuitem" data-drupal-link-system-path="node/86122">Divisions, Offices and Centers</a>
					
									</li>


				

															<li  >
											<a href="/about/advisory-and-peer-review-committees" role="menuitem" data-drupal-link-system-path="node/80100">Advisory Committees</a>
					
									</li>


				

															<li  >
											<a href="/about/budget-and-legislative-information" role="menuitem" data-drupal-link-system-path="node/90263">Budget and Legislative Information</a>
					
									</li>


				

															<li  >
											<a href="/about/working-at-nhlbi" role="menuitem" data-drupal-link-system-path="node/80445">Jobs and Working at the NHLBI</a>
					
									</li>


				

															<li  >
											<a href="/contact" role="menuitem" data-drupal-link-system-path="node/93979">Contact and FAQs</a>
					
									</li>


				

															<li  >
											<a href="/sleep-research-plan" role="menuitem" data-drupal-link-system-path="node/92164">NIH Sleep Research Plan</a>
					
									</li>


				

					</ul>
	
									</li>


				

					</ul>
	
									</div>
								</div>
							</li>
						
						<li class="active menu-item-link-home menu-item-link menu-item--active-trail expand-vertical" role="menuitem">
							<div class="level-0-link-home" id="main-menu-item-home-button" tabindex="0">
								<a href="/">
									HOME
								</a>
							</div>
						</li>
					</ul>
							</div>
		</div>
		<div id="global-search-bar-phone">
			<div class="global-search-bar">
				<form action="/site-search" method="GET">
					<label for="searchQueryText_phone">
						<span class="visually-hidden">
							Search Text:
						</span>
					</label>
					<input id="searchQueryText_phone" type="text" name="searchtext" placeholder="Search the NHLBI" autocomplete="off">
					<input type="submit" class="submit-button" aria-label="Global Search Mobile" label="Global Search Button">
				</form>
			</div>
		</div>
	</div>
</div>



  </div>

	<div id="main-menu-blur-shadow">
	</div>

	<div id="main-menu-blur-shadow-tablet-mobile">
	</div>

	<div id="search-bar-blur-shadow">
	</div>

</div>

  </div>

  </header>

  
  

  

  

  

  <main role="main" id="main" class="row">
    <div id="main-content" tabindex="-1"></div>    
    <div class="flexible two-sidebars">   
 
    <div id="cart-container-wrapper-lightbox"></div>
    <div class="layout-content">
        <div class="region region-content">
    <div data-drupal-messages-fallback class="hidden"></div>



    

    <div class="responsive-container responsive-container-constrained breadcrumbs-container"><div class="breadcrumbs"><ul> <li class='breadcrumb-home'><a href='/'>Home</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-parent'><a href='/node/80002'><span class='back-to'> < Back To </span>The Science</a></li><li class='breacrumb-break'>/</li><li class='breadcrumb-current'>Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program</li></ul></div></div>

<article  class="node node--type-extramural-science-instance node--view-mode-full"
        data-title="Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program"
        data-type="extramural_science_instance"
        data-format=""
        data-audience=""
        data-campaign=""
>
    <div class="standard">
                              <div class="field field--name-field-top-texture-banner field--type-list-string field--label-hidden field__item">
                                            <div class="pageBanner">
            <div class="banner-new-red"></div>
          </div>
              </div>
    
                
                    <div class="secondary-grey-background">
        <div class="responsive-container responsive-container-constrained">
            <div class="content-container page-top">
                <div class="rtFlexContainer">
                    <div class="rtTitleClassification">
                        
                        <h1>
                            
<span>Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program</span>

                        </h1>
                        
                                                <div class="content-indent">
                            
      <div class="field field--name-field-descriptor field--type-entity-reference-revisions field--label-hidden field__items">
              <div class="field__item"><div class="paragraph paragraph--type--science-instance-descriptor paragraph--view-mode--default">
    <div class="silabel">
        
            <div class="field field--name-field-display-title field--type-string field--label-hidden field__item">Project began</div>
      
    </div>
            <div class="bodytext">
            
            <div class="field field--name-field-text-information field--type-string field--label-hidden field__item">2014</div>
      
        </div>
                
    </div></div>
              <div class="field__item"><div class="paragraph paragraph--type--science-instance-descriptor paragraph--view-mode--default">
    <div class="silabel">
        
            <div class="field field--name-field-display-title field--type-string field--label-hidden field__item">Points of contact</div>
      
    </div>
            <div class="bodytext">
            
            <div class="field field--name-field-text-information field--type-string field--label-hidden field__item">Zorina Galis, Ph.D.;Marc Charette, Ph.D.</div>
      
        </div>
                
    </div></div>
          </div>
  
                        </div>
                    </div>
                                        <div class="onThisPage">
                        <div class="pagenavtitle">
                            On this page
                        </div>
                        <ul>
                                                            <li>At a Glance</li>
                                                                                                                    <li>
                                                                                                                                                Contribution to Science
                                </li>
                                                            <li>
                                                                                                                                                How It Works
                                </li>
                                                            <li>
                                                                                                                                                Current Projects
                                </li>
                                                            <li>
                                                                                                                                                Previous Projects
                                </li>
                                                                                                            </ul>
                    </div>
                </div>
            </div>
        </div>
    </div>
        <div class="responsive-container responsive-container-constrained">
        <div class="content-container goal-of-study narrow-desktop">
                        <h2>
            <div class="field field--name-field-goal-title field--type-string field--label-hidden field__item">What is the goal of the VITA Program?</div>
      </h2>
                        
            <div class="field field--name-field-goal-description field--type-text-long field--label-hidden field__item"><p>The NHLBI funds translational research programs, such as the VITA Program, to enable and accelerate the development of promising diagnostics and treatments for unmet and underserved medical needs. Translation is the process of turning research findings into useful diagnostics, interventions, procedures, or treatments. It also involves sharing the findings with the public and health professionals to implement medical advances and improve public health.</p>

<p>The goal of the VITA Program is to support pre-clinical translational development of new diagnostics and treatments in the fields of vascular disorders such as aortic aneurysm; thrombotic diseases such as deep vein thrombosis; and pulmonary hypertension. Pre-clinical research involves developing and testing interventions using cell or animal models of disease; samples of human or animal tissues; or other research models of drug, device, or diagnostic interactions with living systems. Pre-clinical research connects the basic science of disease with human medicine.</p></div>
      
        </div>
    </div>
                <div class="primaryBlueBackground">
            <div class="responsive-container responsive-container-constrained">
                <div class="content-container at-a-glance storycalloutbox">
                                        <div class="storycallouttitle" id="ataglance"><h2 class="at-a-glance-header">AT A GLANCE</h2></div>
                                        <div class="storycallouttext storycalloutlist">
                        
<div class="field field--name-field-at-a-glance field--type-string field--label-hidden field__items">
  <ul>
          <li><div class="field__item calloutdata font-size-xl">VITA’s first phase included nine pre-clinical and early stage clinical projects from 2014 to 2016.</div></li>
          <li><div class="field__item calloutdata font-size-xl">The first VITA researchers published over 15 scientific articles from their VITA work during the program.</div></li>
          <li><div class="field__item calloutdata font-size-xl">VITA’s first phase led to 16 patent applications and helped license a new drug technology.</div></li>
          <li><div class="field__item calloutdata font-size-xl">The first phase led to two clinical trials and helped two applications enter the FDA regulatory process. </div></li>
          <li><div class="field__item calloutdata font-size-xl">The first VITA investigators have formed a new collaboration and one non-profit start-up.</div></li>
          <li><div class="field__item calloutdata font-size-xl">VITA’s second phase, which began in November of 2016, includes nine pre-clinical and early stage clinical projects.</div></li>
      </ul>
</div>



                    </div>
                </div>
            </div>
        </div>
            <div class="responsive-container responsive-container-constrained">
        <div class="content-container narrow-desktop">
            
      <div class="field field--name-field-standard-content field--type-entity-reference-revisions field--label-hidden field__items">
              <div class="field__item">        <h2 id="contribution-to-science">
            <div class="field field--name-field-standard-title field--type-string field--label-hidden field__item">How does the VITA Program contribute to scientific discoveries?</div>
      </h2>
    <div class="bodytext">
        
            <div class="field field--name-field-description field--type-text-long field--label-hidden field__item"><p>In 2016 NHLBI released its Strategic Vision, which will guide the Institute’s research activities for the coming decade. VITA’s mission helps realize one of NHLBI’s strategic goals: to facilitate innovation and accelerate research translation across the entire research spectrum, bridging basic to clinical, clinical to practice, and population to health impact. VITA supports several NHLBI Strategic Vision objectives.</p></div>
      
    </div>
    <div class="supplemental-accordion">
    
      <div class="field field--name-field-accordion field--type-entity-reference-revisions field--label-hidden field__items">
              <div class="field__item">
    <h3 class="graysubaccordionheading" id="more-information-988">
        	
            <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">More Information</div>
      
	<span class="ui-helper-hidden-accessible">
		-
		Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program
	</span>
    </h3>
    <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" >
                                            <div class="bodytext">
                    
            <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p>The VITA program focuses on early and late-stage translational research:</p>

<ul><li><strong>Early-stage</strong>: concept to proof-of-principle studies</li>
	<li><strong>Late-stage</strong>: proof-of-principle to investigational new drug (IND) or investigational new device (IDE) studies</li>
</ul><p>Currently, VITA is supporting research on a variety of medical challenges and developing new diagnostics and treatments to address these challenges, including:</p>

<ul><li>Prevention of post-operative vascular injury</li>
	<li>Novel anti-thrombotic therapy with improved safety</li>
	<li>Drug therapy for vascular leakage</li>
	<li>Pulmonary arterial hypertension diagnosis and therapy</li>
	<li>Therapy for reversal of limb ischemia</li>
</ul><p> </p></div>
      
                </div>
                                        <div class="readMoreContainer">
                                </div>
                                                            </div>

</div>
          </div>
  
    </div>
</div>
              <div class="field__item">        <h2 id="how-it-works">
            <div class="field field--name-field-standard-title field--type-string field--label-hidden field__item">How does the VITA Program work?</div>
      </h2>
    <div class="bodytext">
        
            <div class="field field--name-field-description field--type-text-long field--label-hidden field__item"><p>VITA promotes translation of research discoveries by using a contract mechanism and a milestone-based approach. VITA provides research and development contract funding and operational support for up to three years for early-stage product candidate development by academic researchers or small businesses. VITA supports a framework to enable the success of pre-clinical translational projects by providing funding and access to resources such as:</p>

<ul><li>NHLBI project funding and support</li>
	<li>An external advisory committee that provides guidance and expert advice for new product development</li>
	<li>A program coordinating center that provides project management support and regulatory advice</li>
	<li>An investigators’ forum for productive exchange of scientific expertise and collaboration</li>
	<li>Access to other NHLBI/NIH resources and services</li>
</ul></div>
      
    </div>
    <div class="supplemental-accordion">
    
      <div class="field field--name-field-accordion field--type-entity-reference-revisions field--label-hidden field__items">
              <div class="field__item">
    <h3 class="graysubaccordionheading" id="more-information-990">
        	
            <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">More Information</div>
      
	<span class="ui-helper-hidden-accessible">
		-
		Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program
	</span>
    </h3>
    <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" >
                                            <div class="bodytext">
                    
            <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p>VITA facilitates partnerships among government, industry, not-for-profit groups, professional associations, and consortia to address research needs and barriers identified by the scientific community, including:</p>

<ul><li>Medical needs not met by industry for several diseases and conditions</li>
	<li>Early product concepts and ideas that are untested</li>
	<li>Scarcity of funding for early product concepts or not enough NIH funds for basic research</li>
	<li>Challenges some researchers experience when pursuing early product development</li>
	<li>Lack of knowledge of or local access to needed resources</li>
</ul></div>
      
                </div>
                                        <div class="readMoreContainer">
                                </div>
                                                            </div>

</div>
          </div>
  
    </div>
</div>
              <div class="field__item">        <h2 id="current-projects">
            <div class="field field--name-field-standard-title field--type-string field--label-hidden field__item">What are the current VITA (2016–2018) projects?</div>
      </h2>
    <div class="bodytext">
        
    </div>
    <div class="supplemental-accordion">
    
      <div class="field field--name-field-accordion field--type-entity-reference-revisions field--label-hidden field__items">
              <div class="field__item">
    <h3 class="graysubaccordionheading" id="innovative-drug-device-combination-for-prevention-of-restenosis-992">
        	
            <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">Innovative drug/device combination for prevention of restenosis</div>
      
	<span class="ui-helper-hidden-accessible">
		-
		Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program
	</span>
    </h3>
    <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" >
                                            <div class="bodytext">
                    
            <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p>Michael S. Conte, M.D.<br />
The University of California at San Francisco</p>

<p>The goal of this VITA Program contract is to use this biology to develop a prototype medical drug or device that effectively prevents restenosis and reduces vascular scarring. The problem of vascular injury is pervasive throughout cardio-vascular surgical procedures, including vascular access, angioplasty, stenting and bypass surgery. Failure due to restenosis and vascular scarring is a continuing complication of most vascular interventions, creating an unmet medical need. Despite advances in drug‐eluting devices, most restenosis-blocking agents are harmful to cells and inhibit rather than promote vessel wall healing.  Recent studies suggest that specialized bioactive lipid mediators help resolve inflammatory reactions and have beneficial activity in healing vascular tissues.</p></div>
      
                </div>
                                        <div class="readMoreContainer">
                                </div>
                                                            </div>

</div>
              <div class="field__item">
    <h3 class="graysubaccordionheading" id="developing-first-in-class-anti-thrombotic-monoclonal-antibody-993">
        	
            <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">Developing first-in-class anti-thrombotic monoclonal antibody</div>
      
	<span class="ui-helper-hidden-accessible">
		-
		Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program
	</span>
    </h3>
    <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" >
                                            <div class="bodytext">
                    
            <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p>Glen Gaughan, Ph.D., M.B.A.<br />
Sujana Biotech</p>

<p>The goal of this project is to produce a first-in-class, or novel target, anti-thrombotic monoclonal antibody with improved safety such as a reduced risk of bleeding and improved or equivalent effectiveness compared to current medicines. While the current FDA-approved platelet inhibitors and anticoagulants are effective in reducing ischemic events, they are also associated with a 60 to 300 percent higher bleeding rate and with an increased risk of later death. Other programs exploiting alternative targets have not yet provided new, safer therapeutics. This project hopes to capitalize on a promising, well-characterized and effective polyclonal antibody to develop a commercially acceptable clinical candidate—a fully humanized monoclonal antibody.</p></div>
      
                </div>
                                        <div class="readMoreContainer">
                                </div>
                                                            </div>

</div>
              <div class="field__item">
    <h3 class="graysubaccordionheading" id="novel-drug-based-therapy-for-treatment-of-vascular-leakage-994">
        	
            <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">Novel drug-based therapy for treatment of vascular leakage</div>
      
	<span class="ui-helper-hidden-accessible">
		-
		Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program
	</span>
    </h3>
    <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" >
                                            <div class="bodytext">
                    
            <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p>Yulia Komarova, Ph.D.<br />
University of Illinois at Chicago</p>

<p>The goal of this application is to develop a highly effective drug-based therapy for the treatment of vascular leakage and accompanying inflammation in the lungs of patients with Acute Respiratory Distress Syndrome (ARDS). ARDS is a life-threatening condition characterized by severe leakage of plasma proteins into the interstitium and accumulation of inflammatory cells into the alveolar space. ARDS is associated with pneumonia, sepsis and septic shock, trauma, and the need for a lung transplant and multiple transfusions. ARDS can lead to pulmonary insufficiency and eventually multisystem organ failure or death.</p></div>
      
                </div>
                                        <div class="readMoreContainer">
                                </div>
                                                            </div>

</div>
              <div class="field__item">
    <h3 class="graysubaccordionheading" id="novel-anti-thrombotic-drug-combination-995">
        	
            <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">Novel anti-thrombotic drug combination</div>
      
	<span class="ui-helper-hidden-accessible">
		-
		Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program
	</span>
    </h3>
    <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" >
                                            <div class="bodytext">
                    
            <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p>Daniel Myers, Jr., D.V.M., M.P.H. and Thomas Wakefield, M.D.<br />
University of Michigan</p>

<p>The goal of this project is to determine if the combination of an E-selectin inhibitor and standard low molecular-weight heparin therapy can significantly reduce thrombosis and inflammation without increasing adverse bleeding. Venous thromboembolism, which includes deep vein thrombosis and pulmonary embolism, is a serious and potentially fatal set of conditions that can cause significant morbidity and mortality. This project is exploring E-selectin inhibitors because selectins are involved in the interrelated processes of inflammation and thrombosis.</p></div>
      
                </div>
                                        <div class="readMoreContainer">
                                </div>
                                                            </div>

</div>
              <div class="field__item">
    <h3 class="graysubaccordionheading" id="novel-non-invasive-diagnosis-of-pulmonary-vascular-disease-996">
        	
            <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">Novel non-invasive diagnosis of pulmonary vascular disease</div>
      
	<span class="ui-helper-hidden-accessible">
		-
		Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program
	</span>
    </h3>
    <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" >
                                            <div class="bodytext">
                    
            <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p>Sudarshan Rajagopal, M.D., Ph.D. and Bastiaan Driehuys, Ph.D.<br />
Duke University</p>

<p>The goal of this project is to identify imaging features that permit pulmonary vascular disease (PVD) to be identified in patients who also may have heart and lung diseases. This project will apply an integrated structural and functional magnetic resonance imaging (MRI) protocol to detect regional gas exchange abnormalities associated with PVD. It will do so by advancing a novel technology that uses inhaled xenon gas MRI, a test that takes images of the body’s organs without using x-rays, to enable non-invasive imaging of pulmonary gas exchange. The successful development of such a technology could provide a sensitive and specific means of non-invasively diagnosing and monitoring PVD during a brief MRI exam. Non-invasive diagnosis and monitoring of PVD remains a serious challenge.</p></div>
      
                </div>
                                        <div class="readMoreContainer">
                                </div>
                                                            </div>

</div>
              <div class="field__item">
    <h3 class="graysubaccordionheading" id="novel-therapy-for-pulmonary-arterial-hypertension-997">
        	
            <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">Novel therapy for pulmonary arterial hypertension</div>
      
	<span class="ui-helper-hidden-accessible">
		-
		Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program
	</span>
    </h3>
    <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" >
                                            <div class="bodytext">
                    
            <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p>Paul De Silva Jardine, Ph.D. and Hyung Chun, M.D.<br />
Vascumab, LLC</p>

<p>The goal of this project is to develop novel therapies for pulmonary arterial hypertension (PAH) that target the disease processes underlying PAH, possibly reverse disease, or improve survival rates. Pulmonary arterial hypertension (PAH) is a debilitating disease that involves remodeling of the arterial blood vessels in the lungs, and it can lead to heart failure or death. There is no available cure for this potentially life-threatening disease. Current treatments alleviate symptomatic vasoconstriction through their vasodilation properties, but they do not target the underlying diseases processes that drive pulmonary vascular remodeling in PAH.</p></div>
      
                </div>
                                        <div class="readMoreContainer">
                                </div>
                                                            </div>

</div>
              <div class="field__item">
    <h3 class="graysubaccordionheading" id="new-drug-for-pulmonary-arterial-hypertension-998">
        	
            <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">New drug for pulmonary arterial hypertension</div>
      
	<span class="ui-helper-hidden-accessible">
		-
		Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program
	</span>
    </h3>
    <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" >
                                            <div class="bodytext">
                    
            <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p>Tom Driver, Ph.D. and Roberto Machado, M.D.<br />
University of Illinois at Chicago</p>

<p>This project will inhibit a pathway involved in pulmonary vascular remodeling and assess the potential of these inhibitors as possible new medicines for pulmonary arterial hypertension (PAH). Pulmonary arterial hypertension (PAH) is a debilitating disease that involves remodeling of the arterial blood vessels in the lungs, and it can lead to heart failure or death. There is no available cure for this potentially life-threatening disease. Current treatments alleviate symptomatic vasoconstriction through their vasodilation properties, but they do not target the underlying diseases processes that drive pulmonary vascular remodeling in PAH.</p></div>
      
                </div>
                                        <div class="readMoreContainer">
                                </div>
                                                            </div>

</div>
              <div class="field__item">
    <h3 class="graysubaccordionheading" id="innovative-targeting-therapy-for-reversal-of-limb-ischemia-999">
        	
            <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">Innovative targeting therapy for reversal of limb ischemia</div>
      
	<span class="ui-helper-hidden-accessible">
		-
		Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program
	</span>
    </h3>
    <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" >
                                            <div class="bodytext">
                    
            <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p>Omaida C. Velazquez, M.D. and Zhao-Jun Liu, Ph.D., M.D.<br />
University of Miami</p>

<p>The goal of this project is to develop novel gene- and cell-based therapeutic strategies that will improve both tissue microenvironment and precision targeting of bone marrow-derived tissue repair cells (TRCs) to accelerate new vascular growth in the limbs of patients who have suffered critical limb ischemia. Critical limb ischemia is a severe blockage of the arteries that supply blood to the limbs and represents an advanced stage of peripheral arterial disease (PAD), a type of cardiovascular disease. Bone marrow-derived TRCs have been identified as a new therapeutic option to induce therapeutic angiogenesis. The researchers propose to test feasibility and efficacy of adhesion molecule-based extracellular and cellular components in mouse limb ischemia and gangrene models. This preclinical study is translatable for developing and optimizing safe and effective gene- and stem cell-based therapies for clinical trials.</p></div>
      
                </div>
                                        <div class="readMoreContainer">
                                </div>
                                                            </div>

</div>
              <div class="field__item">
    <h3 class="graysubaccordionheading" id="anti-thrombotic-therapy-with-minimal-bleeding-profile-1000">
        	
            <div class="field field--name-field-panel-title field--type-string field--label-hidden field__item">Anti-thrombotic therapy with minimal bleeding profile</div>
      
	<span class="ui-helper-hidden-accessible">
		-
		Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program
	</span>
    </h3>
    <div class="ui-accordion ui-widget ui-helper-reset paragraph paragraph--type--standard-accordion-panelparagraph--view-mode--default" >
                                            <div class="bodytext">
                    
            <div class="field field--name-field-accordion-body field--type-text-long field--label-hidden field__item"><p>Minyi Gu, M.D. and Xiaoping Du, M.D., Ph.D.<br />
DuPage Medical Technology, Inc.</p>

<p>The goal of this project is to develop a new generation of anti-thrombotic agents that inhibit occlusive thrombosis but also have minimal bleeding side effects. Currently, the major drugs used to treat arterial thrombosis have a common and potentially life-threatening adverse event of bleeding. Arterial thrombosis, which causes ischemia in vital organs, is common in older adults, and the disease is expected to increase with an aging U.S. population. </p></div>
      
                </div>
                                        <div class="readMoreContainer">
                                </div>
                                                            </div>

</div>
          </div>
  
    </div>
</div>
              <div class="field__item">        <h2 id="previous-projects">
            <div class="field field--name-field-standard-title field--type-string field--label-hidden field__item">What were the previous VITA (2014–2016) projects?</div>
      </h2>
    <div class="bodytext">
        
            <div class="field field--name-field-description field--type-text-long field--label-hidden field__item"><p><a href="https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=12ECC90F4B8ECED07598B8961CAA4A01A2FFCEB861BF" rel="noreferrer">New methodology and tools for monitoring pulmonary arterial hypertension</a><br />
Raymond L. Benza, M.D.<br />
The Allegheny Singer Research Institute</p>

<p><a href="https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=12ECC90F4B89C2D17598B8961CAA4A01A2FFCEB861BF" rel="noreferrer">Innovative bioengineered vascular graft substitute for peripheral arterial disease</a><br />
Allison Pilgrim, BM, B.Ch., D.Phil.<br />
Humacyte, Inc.</p>

<p><a href="https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=12ECC90F4B89CED47598B8961CAA4A01A2FFCEB861BF" rel="noreferrer">New pharmacological therapy for vascular malformations</a><br />
Ramani Ramchandran, Ph.D.<br />
The Medical College of Wisconsin</p>

<p><a href="https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=12ECC90F4B88C6D77598B8961CAA4A01A2FFCEB861BF" rel="noreferrer">Novel drug treatment for pulmonary arterial hypertension</a><br />
Lawrence Zisman, M.D.<br />
Pulmokine, Inc.</p>

<p><a href="https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=12ECC90F4B88C5DE7598B8961CAA4A01A2FFCEB861BF" rel="noreferrer">New anti-thrombotic therapy with minimal bleeding profile</a><br />
Xiaoping Du, M.D., Ph.D.<br />
The University of Illinois at Chicago</p>

<p><a href="https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=12ECC90F4B88C3D47598B8961CAA4A01A2FFCEB861BF" rel="noreferrer">Novel anti-thrombotic drug for deep vein thrombosis</a><br />
Suman Sood, M.D.<br />
Thomas Wakefield, M.D.<br />
The University of Michigan</p>

<p><a href="https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=12ECC90F4B88C1D37598B8961CAA4A01A2FFCEB861BF" rel="noreferrer">Innovative drug/device combination for prevention of restenosis</a><br />
Michael S. Conte, M.D.<br />
The University of California at San Francisco</p>

<p><a href="https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=12ECC90F4B88CFD47598B8961CAA4A01A2FFCEB861BF" rel="noreferrer">New mechanism-of-action drug for treatment of hypertension</a><br />
L. Jackson Roberts, II, M.D.<br />
David G. Harrison, M.D.<br />
Vanderbilt University</p>

<p><a href="https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=12ECC90F4B8BC6DE7598B8961CAA4A01A2FFCEB861BF" rel="noreferrer">Novel therapeutic adjuvant for pulmonary arterial hypertension therapy</a><br />
David M. Mann<br />
Vascular BioSciences, Inc.</p></div>
      
    </div>
    <div class="supplemental-accordion">
    
    </div>
</div>
          </div>
  
        </div>
    </div>
                                <div class="responsive-container responsive-container-constrained">
                    <div class="related-ht-press-container content-container-margin">
                                                                                                            <div class="card">
                                    <h2>Related Scientific Focus Areas</h2>
                                    <div class="related-topics">
                                        
      <div class="field field--name-field-related-sfas field--type-entity-reference field--label-hidden field__items">
              <div class="field__item"><a href="/science/heart-and-vascular-diseases" hreflang="en">Heart and Vascular Diseases</a></div>
              <div class="field__item"><a href="/science/lung-diseases" hreflang="en">Lung Diseases</a></div>
              <div class="field__item"><a href="/science/blood-disorders-and-blood-safety" hreflang="en">Blood Disorders and Blood Safety</a></div>
          </div>
  
                                    </div>
                                </div>
                                                                                                                                                                <div class="card">
                                    <h2>Related Health Topics</h2>
                                    <div class="related-topics">
                                        

      <div class="field field--name-field-related-health-topics field--type-entity-reference field--label-hidden field__items">
              <div class="field__item"><a href="/node/92320" hreflang="en">High Blood Pressure</a></div>
              <div class="field__item"><a href="/health/peripheral-artery-disease" hreflang="en">What Is Peripheral Artery Disease?</a></div>
              <div class="field__item"><a href="/health/pulmonary-hypertension" hreflang="en">What Is Pulmonary Hypertension?</a></div>
          </div>
  

                                    </div>
                                </div>
                                                                        </div>
            </div>
                        </div>
</article>
  </div>

    </div>
    
        </div>
  </main>

      <footer role="contentinfo">
        <div class="region region-footer">
    <div id="block-footerblock" class="block block-block-content block-block-contente34e68d7-0b62-4cbe-ada1-9e43b89bc1ac">
  
    
        <div class="responsive-container responsive-container-constrained layout layout--onecol">
    <div  class="layout__region layout__region--content">
      


<nav role="navigation" aria-labelledby="back-to-top-link-menu"  class="block block-menu navigation menu--back-to-top-link">

        
  
  <div  class="visually-hidden" id="back-to-top-link-menu" class="h2">
    Back To Top Link
  </div>
  

        

        <div  class="menu">
                      <div class="menu-item"
                           class="menu-item" style="height:1em;"
              >
                    <a href="#main-content" class="back-to-top-link">Back to top</a>
                      </div>
        </div>
  

  </nav>

    </div>
  </div>
  <div class="layout layout--threecol-section layout--threecol-section--33-34-33 footer-top responsive-container responsive-container-constrained">

          <div  class="layout__region layout__region--first">
        


<nav role="navigation" aria-labelledby="web-policies-notices-menu"  class="block block-menu navigation menu--web-policies-notices">

  
  
  <div  id="web-policies-notices-menu" class="h2">
    Web Policies & Notices
  </div>
  

        

              <ul class="menu">
                          <li class="menu-item"
                      >
        <a href="/about/contact/website-privacy-and-accessibility" data-drupal-link-system-path="node/94303">Accessibility</a>
              </li>
                      <li class="menu-item"
                      >
        <a href="https://www.edi.nih.gov/no-fear-act" rel="noreferrer"> No FEAR Act Data</a>
              </li>
                      <li class="menu-item"
                      >
        <a href="/about/contact/website-privacy-and-accessibility/privacy-statement" data-drupal-link-system-path="node/122847">Privacy Policy</a>
              </li>
                      <li class="menu-item"
                      >
        <a href="/about/contact/website-privacy-and-accessibility" data-drupal-link-system-path="node/94303">Freedom of Information Act (FOIA)</a>
              </li>
                      <li class="menu-item"
                      >
        <a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" rel="noreferrer">HHS Vulnerability Disclosure</a>
              </li>
        </ul>
  

  </nav>

      </div>
    
          <div  class="layout__region layout__region--second">
        


<nav role="navigation" aria-labelledby="related-government-websites-menu"  class="block block-menu navigation menu--related-government-websites">

  
  
  <div  id="related-government-websites-menu" class="h2">
    Related Government Websites
  </div>
  

        

              <ul class="menu">
                          <li class="menu-item"
                      >
        <a href="https://www.hhs.gov/" rel="noreferrer">Health and Human Services</a>
              </li>
                      <li class="menu-item"
                      >
        <a href="https://www.nih.gov/" rel="noreferrer">National Institutes of Health</a>
              </li>
                      <li class="menu-item"
                      >
        <a href="https://oig.hhs.gov/" rel="noreferrer">Office of the Inspector General</a>
              </li>
                      <li class="menu-item"
                      >
        <a href="https://www.usa.gov/" rel="noreferrer">USA.gov</a>
              </li>
        </ul>
  

  </nav>

      </div>
    
          <div  class="layout__region layout__region--third">
        <div class="block block-block-content block-block-content9c447866-1f95-4857-a5d6-00015338372f">
  
      <div  class="h2">
      Stay Connected
    </div>
    
      
            <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><ul class="ft-stay-connected"><li class="live-chat-link"><p><img class="b-lazy b-loaded is-b-loaded b-lazy" alt="chat bubbles" height="30" loading="lazy" width="auto" data-src="/themes/custom/nhlbi/images/messages-question-regular.svg" src="/modules/custom/nhlbi_blazy/images/clear.png" /><a class="ext" href="#" onclick="window.open('https://nhlbichat.iqsolutions.com/chatbeacon/NIH/1/survey/survey?accountId=1&siteId=1&queueId=1&theme=blue&popout=true&sessionId=602860bd-6613-4f2f-a3b6-bf1cf9f4d39f&visitorId=9ca462e3-5378-4b69-90b9-b38ce5259877&ispopout=true&pc=true','Live Chat','width=435,height=700'); return false;" target="_blank" rel="noopener">Live Chat</a><span class="ext-icon" tabindex="0">  </span></p><p>Live Chat with us, Monday through Friday, 8:30 a.m. to 5:00 p.m. EST.</p></li><li class="emails-alert-link"><p><img class="b-lazy b-loaded is-b-loaded b-lazy" alt="envelope" height="30" loading="lazy" width="auto" data-src="/themes/custom/nhlbi/images/envelope-open-text-solid.svg" src="/modules/custom/nhlbi_blazy/images/clear.png" />Get Email Alerts</p><p>Receive automatic alerts about NHLBI related news and highlights from across the Institute.</p></li></ul></div>
      
  </div>

      </div>
    
  </div>
  <div class="layout-section-background-dark-blue layout layout--onecol">
    <div  class="layout__region layout__region--content">
      


<nav role="navigation" aria-labelledby="footer-bottom-menu"  class="block block-menu navigation menu--footer-bottom">

        
  
  <div  class="visually-hidden" id="footer-bottom-menu" class="h2">
    Footer Bottom
  </div>
  

        



<div id="footer-bottom-container" class="responsive-container responsive-container-constrained">
        <div class="footer-bottom-logo">
            <a aria-label="home" href="/">
                <img class="b-lazy" data-src="/themes/custom/nhlbi/images/NHLBI_HHS_Lockup_white.svg" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" alt="National Heart, Lung, and Blood Home"/>
            </a>
        </div>
        <div class="footer-bottom-links">
                            <ul>
                            <li>
                    <a href="/contact" data-drupal-link-system-path="node/93979"> Contact Us</a>
                                    </li>
                            <li>
                    <a href="/siteindex" data-drupal-link-system-path="node/83138">Site Index</a>
                                    </li>
                            <li>
                    <a href="/about/working-at-nhlbi" data-drupal-link-system-path="node/80445">Jobs</a>
                                    </li>
                    </ul>
    
        </div>
        <div class="footer-bottom-social">
            <ul id="footer-social">
                <li><a id="facebooklink" href="https://www.facebook.com/NHLBI/"><img src="/themes/custom/nhlbi/images/ico-facebook-white.svg" alt="Facebook social media"></a></li>
                <li><a id="twitterlink" href="https://twitter.com/nih_nhlbi?lang=en"><img src="/themes/custom/nhlbi/images/x-twitter-logo.svg" alt="X social media"></a></li>
                <li><a id="youtubelink" href="https://www.youtube.com/user/NHLBI"><img src="/themes/custom/nhlbi/images/ico-youtube-white.svg" alt="Youtube social media"></a></li>
                <li><a id="linkedinlink" href="https://www.linkedin.com/company/national-heart-lung-and-blood-institute"><img src="/themes/custom/nhlbi/images/linkedin-brands.svg" alt="LinkedIn social media"></a></li>
            </ul>
        </div>
</div>

  </nav>

    </div>
  </div>

  </div>

  </div>

    </footer>
  
</div>
  </div>

    

    
    <form  id="publication-checkout" action="https://catalog.nhlbi.nih.gov/checkout" method="post">
      <input type="hidden" name="orderId" value="">
      <input type="hidden" name="payload" value="">
      <input type="submit" value="Checkout">
    </form>

    <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","scriptPath":null,"pathPrefix":"","currentPath":"node\/80050","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"embedButtons":{"media_embed":{"id":"media_embed","icon":"\/modules\/contrib\/entity_embed\/js\/plugins\/drupalentity\/entity.png"},"node":{"id":"node","icon":"\/modules\/contrib\/entity_embed\/js\/plugins\/drupalentity\/entity.png"}},"modulePath":"modules\/contrib\/entity_embed","ajaxPageState":{"libraries":"addtoany\/addtoany.front,blazy\/bio.ajax,classy\/node,core\/drupal.dialog,crazyegg\/crazyegg,fontawesome\/fontawesome.webfonts.brands,fontawesome\/fontawesome.webfonts.custom,fontawesome\/fontawesome.webfonts.light,fontawesome\/fontawesome.webfonts.regular,fontawesome\/fontawesome.webfonts.sharplight,fontawesome\/fontawesome.webfonts.sharpregular,fontawesome\/fontawesome.webfonts.sharpsolid,fontawesome\/fontawesome.webfonts.solid,fontawesome\/fontawesome.webfonts.thin,layout_builder\/threecol_section,layout_discovery\/onecol,nhlbi\/adobe_launch,nhlbi\/global-styling,nhlbi\/standard-accordion-readmore-print,nhlbi\/uswds,nhlbi_ckeditor\/nhlbi_entity_embed,nih_extlink\/drupal.nih_extlink,paragraphs\/drupal.paragraphs.unpublished,system\/base,views\/views.ajax,views\/views.module,views_ajax_history\/history","theme":"nhlbi","theme_token":null},"ajaxTrustedUrl":[],"data":{"nih_extlink":{"extTarget":true,"extClass":"ext","extLabel":"","extImgClass":false,"extSubdomains":false,"extExclude":".*.nih.gov","extInclude":"","extCssExclude":"","extCssExplicit":"","extIconAlert":true,"extIconAlertTitle":"External Web Site Policy","extIconAlertText":"\u003Cp\u003EThis graphic notice (\u003Cimg alt=\u0022External Web Site Policy\u0022 height=\u002210\u0022 src=\u0022https:\/\/www.nhlbi.nih.gov\/files\/images\/external-link.png\u0022 title=\u0022External Web Site Policy\u0022 width=\u002210\u0022 \/\u003E) means that you are leaving the NIH website.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThis external link provides additional information that is consistent with the intended purpose of this site.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ENIH cannot attest to the accuracy of a non-federal site.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELinking to a non-federal site does not constitute an endorsement by NIH or any of its employees of the sponsors or the information and products presented on the site.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EYou will be subject to the destination site\u2019s privacy policy when you follow the link.\u003C\/p\u003E\r\n","extAlert":true,"extAlertText":"","mailtoClass":"0","mailtoLabel":""}},"viewsAjaxHistory":{"renderPageItem":0,"initialExposedInput":{"views_dom_id:18891c93ff68a64a8939d0fcd8025abf218e143c2aa7c3b063abe56eec3fc955":null}},"views":{"ajax_path":"\/views\/ajax","ajaxViews":{"views_dom_id:18891c93ff68a64a8939d0fcd8025abf218e143c2aa7c3b063abe56eec3fc955":{"view_name":"nhlbi_news_science","view_display_id":"block_1","view_args":"80050","view_path":"\/node\/80050","view_base_path":null,"view_dom_id":"18891c93ff68a64a8939d0fcd8025abf218e143c2aa7c3b063abe56eec3fc955","pager_element":0}}},"hearts":{"heartsJS":{"markers":[{"lat_value":"43.0389025","lon_value":"-87.9064736","count_value":"12","marker_size_value":"3","geohash_value":false,"name_value":"Milwaukee, WI","type_value":"post"},{"lat_value":"38.0293059","lon_value":"-78.4766781","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Charlottesville, VA","type_value":"post"},{"lat_value":"38.2526647","lon_value":"-85.7584557","count_value":"8","marker_size_value":"2","geohash_value":false,"name_value":"Louisville, KY","type_value":"post"},{"lat_value":"31.549333","lon_value":"-97.1466695","count_value":"7","marker_size_value":"2","geohash_value":false,"name_value":"Waco-Temple-Bryan, TX","type_value":"post"},{"lat_value":"32.4487364","lon_value":"-99.7331439","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Abilene-Sweetwater, TX","type_value":"post"},{"lat_value":"41.6763545","lon_value":"-86.2519898","count_value":"6","marker_size_value":"2","geohash_value":false,"name_value":"South Bend-Elkhart, IN","type_value":"post"},{"lat_value":"36.1539816","lon_value":"-95.992775","count_value":"121","marker_size_value":"3","geohash_value":false,"name_value":"Tulsa, OK","type_value":"post"},{"lat_value":"46.7866719","lon_value":"-92.1004852","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Duluth, MN-Superior, WI","type_value":"post"},{"lat_value":"34.4208305","lon_value":"-119.6981901","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Santa Barbara-Santa Maria-San Luis Obispo, CA","type_value":"post"},{"lat_value":"42.9633599","lon_value":"-85.6680863","count_value":"9","marker_size_value":"2","geohash_value":false,"name_value":"Grand Rapids-Kalamazoo-Battle Creek, MI","type_value":"post"},{"lat_value":"36.1626638","lon_value":"-86.7816016","count_value":"45","marker_size_value":"3","geohash_value":false,"name_value":"Nashville, TN","type_value":"post"},{"lat_value":"36.7377981","lon_value":"-119.7871247","count_value":"19","marker_size_value":"3","geohash_value":false,"name_value":"Fresno-Visalia, CA","type_value":"post"},{"lat_value":"32.298603057861","lon_value":"-90.185050964355","count_value":"1","marker_size_value":"1","geohash_value":"9vxzezc3","name_value":false,"type_value":"event"},{"lat_value":"30.3321838","lon_value":"-81.655651","count_value":"29","marker_size_value":"3","geohash_value":false,"name_value":"Jacksonville, FL","type_value":"post"},{"lat_value":"30.4514677","lon_value":"-91.1871466","count_value":"17","marker_size_value":"3","geohash_value":false,"name_value":"Baton Rouge, LA","type_value":"post"},{"lat_value":"44.0581728","lon_value":"-121.3153096","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Bend, OR","type_value":"post"},{"lat_value":"39.4667034","lon_value":"-87.4139092","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Terre Haute, IN","type_value":"post"},{"lat_value":"35.0456297","lon_value":"-85.3096801","count_value":"4","marker_size_value":"1","geohash_value":false,"name_value":"Chattanooga, TN","type_value":"post"},{"lat_value":"40.357246398926","lon_value":"-74.667549133301","count_value":"1","marker_size_value":"1","geohash_value":"dr4vsfuf","name_value":false,"type_value":"event"},{"lat_value":"41.8239891","lon_value":"-71.4128343","count_value":"6","marker_size_value":"2","geohash_value":false,"name_value":"Providence, RI-New Bedford, MA","type_value":"post"},{"lat_value":"39.2806451","lon_value":"-80.3445341","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Clarksburg-Weston, WV","type_value":"post"},{"lat_value":"46.5891452","lon_value":"-112.0391057","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Helena, MT","type_value":"post"},{"lat_value":"41.9778795","lon_value":"-91.6656232","count_value":"5","marker_size_value":"1","geohash_value":false,"name_value":"Cedar Rapids-Waterloo-Iowa City \u0026 Dubuque, IA","type_value":"post"},{"lat_value":"40.1164204","lon_value":"-88.2433829","count_value":"16","marker_size_value":"3","geohash_value":false,"name_value":"Champaign \u0026 Springfield-Decatur, IL","type_value":"post"},{"lat_value":"32.7764749","lon_value":"-79.9310512","count_value":"5","marker_size_value":"1","geohash_value":false,"name_value":"Charleston, SC","type_value":"post"},{"lat_value":"35.0843859","lon_value":"-106.650422","count_value":"9","marker_size_value":"2","geohash_value":false,"name_value":"Albuquerque-Santa Fe, NM","type_value":"post"},{"lat_value":"41.2459149","lon_value":"-75.8813075","count_value":"21","marker_size_value":"3","geohash_value":false,"name_value":"Wilkes Barre-Scranton, PA","type_value":"post"},{"lat_value":"29.7604267","lon_value":"-95.3698028","count_value":"42","marker_size_value":"3","geohash_value":false,"name_value":"Houston, TX","type_value":"post"},{"lat_value":"37.9715592","lon_value":"-87.5710898","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Evansville, IN","type_value":"post"},{"lat_value":"38.984642028809","lon_value":"-77.094841003418","count_value":"2","marker_size_value":"1","geohash_value":"dqcjv8vq","name_value":false,"type_value":"event"},{"lat_value":"39.0473451","lon_value":"-95.6751576","count_value":"10","marker_size_value":"3","geohash_value":false,"name_value":"Topeka, KS","type_value":"post"},{"lat_value":"33.4734978","lon_value":"-82.0105148","count_value":"5","marker_size_value":"1","geohash_value":false,"name_value":"Augusta, GA","type_value":"post"},{"lat_value":"44.4758825","lon_value":"-73.212072","count_value":"7","marker_size_value":"2","geohash_value":false,"name_value":"Burlington, VT-Plattsburgh, NY","type_value":"post"},{"lat_value":"32.4609764","lon_value":"-84.9877094","count_value":"18","marker_size_value":"3","geohash_value":false,"name_value":"Columbus, GA","type_value":"post"},{"lat_value":"40.2731911","lon_value":"-76.8867008","count_value":"5","marker_size_value":"1","geohash_value":false,"name_value":"Harrisburg-Lancaster-Lebanon-York, PA","type_value":"post"},{"lat_value":"30.6953657","lon_value":"-88.0398912","count_value":"6","marker_size_value":"2","geohash_value":false,"name_value":"Mobile, AL-Pensacola (Ft. Walton Beach), FL","type_value":"post"},{"lat_value":"43.0125274","lon_value":"-83.6874562","count_value":"4","marker_size_value":"1","geohash_value":false,"name_value":"Flint-Saginaw-Bay City, MI","type_value":"post"},{"lat_value":"46.0038232","lon_value":"-112.5347775","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Butte-Bozeman, MT","type_value":"post"},{"lat_value":"37.2089572","lon_value":"-93.2922989","count_value":"4","marker_size_value":"1","geohash_value":false,"name_value":"Springfield, MO","type_value":"post"},{"lat_value":"34.0007104","lon_value":"-81.0348144","count_value":"12","marker_size_value":"3","geohash_value":false,"name_value":"Columbia, SC","type_value":"post"},{"lat_value":"47.5052849","lon_value":"-111.3007715","count_value":"12","marker_size_value":"3","geohash_value":false,"name_value":"Great Falls, MT","type_value":"post"},{"lat_value":"45.232429504395","lon_value":"-88.007698059082","count_value":"1","marker_size_value":"1","geohash_value":"f013m66f","name_value":false,"type_value":"event"},{"lat_value":"30.2240897","lon_value":"-92.0198427","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Lafayette, LA","type_value":"post"},{"lat_value":"33.6356618","lon_value":"-96.6088805","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Sherman, TX-Ada, OK","type_value":"post"},{"lat_value":"29.6516344","lon_value":"-82.3248262","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Gainesville, FL","type_value":"post"},{"lat_value":"48.2329668","lon_value":"-101.2922906","count_value":"4","marker_size_value":"1","geohash_value":false,"name_value":"Minot-Bismarck-Dickinson(Williston), ND","type_value":"post"},{"lat_value":"29.4241219","lon_value":"-98.4936282","count_value":"20","marker_size_value":"3","geohash_value":false,"name_value":"San Antonio, TX","type_value":"post"},{"lat_value":"44.7630567","lon_value":"-85.6206317","count_value":"7","marker_size_value":"2","geohash_value":false,"name_value":"Traverse City-Cadillac, MI","type_value":"post"},{"lat_value":"33.7489954","lon_value":"-84.3879824","count_value":"82","marker_size_value":"3","geohash_value":false,"name_value":"Atlanta, GA","type_value":"post"},{"lat_value":"40.712757110596","lon_value":"-74.006309509277","count_value":"1","marker_size_value":"1","geohash_value":"dr5regw3","name_value":false,"type_value":"event"},{"lat_value":"41.0997803","lon_value":"-80.6495194","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Youngstown, OH","type_value":"post"},{"lat_value":"40.4406248","lon_value":"-79.9958864","count_value":"17","marker_size_value":"3","geohash_value":false,"name_value":"Pittsburgh, PA","type_value":"post"},{"lat_value":"38.907051086426","lon_value":"-77.037162780762","count_value":"1","marker_size_value":"1","geohash_value":"dqcjqfz6","name_value":false,"type_value":"event"},{"lat_value":"43.0481221","lon_value":"-76.1474244","count_value":"10","marker_size_value":"3","geohash_value":false,"name_value":"Syracuse, NY","type_value":"post"},{"lat_value":"40.813616","lon_value":"-96.7025955","count_value":"9","marker_size_value":"2","geohash_value":false,"name_value":"Lincoln \u0026 Hastings-Kearney, NE","type_value":"post"},{"lat_value":"26.1906306","lon_value":"-97.6961026","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Harlingen-Weslaco-Brownsville-McAllen, TX","type_value":"post"},{"lat_value":"39.0997265","lon_value":"-94.5785667","count_value":"57","marker_size_value":"3","geohash_value":false,"name_value":"Kansas City, MO","type_value":"post"},{"lat_value":"61.2180556","lon_value":"-149.9002778","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Anchorage, AK","type_value":"post"},{"lat_value":"35.3859242","lon_value":"-94.3985475","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Ft. Smith-Fayetteville-Springdale-Rogers, AR","type_value":"post"},{"lat_value":"27.5035613","lon_value":"-99.5075519","count_value":"20","marker_size_value":"3","geohash_value":false,"name_value":"Laredo, TX","type_value":"post"},{"lat_value":"47.6062095","lon_value":"-122.3320708","count_value":"58","marker_size_value":"3","geohash_value":false,"name_value":"Seattle-Tacoma, WA","type_value":"post"},{"lat_value":"38.0405837","lon_value":"-84.5037164","count_value":"40","marker_size_value":"3","geohash_value":false,"name_value":"Lexington, KY","type_value":"post"},{"lat_value":"41.877994537354","lon_value":"-87.630043029785","count_value":"2","marker_size_value":"1","geohash_value":"dp3wjztv","name_value":false,"type_value":"event"},{"lat_value":"46.8721284","lon_value":"-113.9940314","count_value":"7","marker_size_value":"2","geohash_value":false,"name_value":"Missoula, MT","type_value":"post"},{"lat_value":"29.9510658","lon_value":"-90.0715323","count_value":"16","marker_size_value":"3","geohash_value":false,"name_value":"New Orleans, LA","type_value":"post"},{"lat_value":"40.3267407","lon_value":"-78.9219698","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Johnstown-Altoona, PA","type_value":"post"},{"lat_value":"36.3134397","lon_value":"-82.3534727","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Tri-Cities, TN-VA","type_value":"post"},{"lat_value":"37.5407246","lon_value":"-77.4360481","count_value":"45","marker_size_value":"3","geohash_value":false,"name_value":"Richmond-Petersburg, VA","type_value":"post"},{"lat_value":"32.3792233","lon_value":"-86.3077368","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Montgomery-Selma, AL","type_value":"post"},{"lat_value":"29.423961639404","lon_value":"-98.493804931641","count_value":"1","marker_size_value":"1","geohash_value":"9v1zqsrp","name_value":false,"type_value":"event"},{"lat_value":"37.0842271","lon_value":"-94.513281","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Joplin, MO-Pittsburg, KS","type_value":"post"},{"lat_value":"31.8456816","lon_value":"-102.3676431","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Odessa-Midland, TX","type_value":"post"},{"lat_value":"21.3069444","lon_value":"-157.8583333","count_value":"13","marker_size_value":"3","geohash_value":false,"name_value":"Honolulu, HI","type_value":"post"},{"lat_value":"42.2711311","lon_value":"-89.0939952","count_value":"5","marker_size_value":"1","geohash_value":false,"name_value":"Rockford, IL","type_value":"post"},{"lat_value":"36.8507689","lon_value":"-76.2858726","count_value":"5","marker_size_value":"1","geohash_value":false,"name_value":"Norfolk-Portsmouth-Newport News, VA","type_value":"post"},{"lat_value":"36.6002378","lon_value":"-121.8946761","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Monterey-Salinas, CA","type_value":"post"},{"lat_value":"34.7303688","lon_value":"-86.5861037","count_value":"16","marker_size_value":"3","geohash_value":false,"name_value":"Huntsville-Decatur (Florence), AL","type_value":"post"},{"lat_value":"28.8052674","lon_value":"-97.0035982","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Victoria, TX","type_value":"post"},{"lat_value":"47.6587802","lon_value":"-117.4260465","count_value":"9","marker_size_value":"2","geohash_value":false,"name_value":"Spokane, WA","type_value":"post"},{"lat_value":"43.0730517","lon_value":"-89.4012302","count_value":"11","marker_size_value":"3","geohash_value":false,"name_value":"Madison, WI","type_value":"post"},{"lat_value":"35.6145169","lon_value":"-88.8139469","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Jackson, TN","type_value":"post"},{"lat_value":"31.3112936","lon_value":"-92.4451371","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Alexandria, LA","type_value":"post"},{"lat_value":"41.49932","lon_value":"-81.6943605","count_value":"28","marker_size_value":"3","geohash_value":false,"name_value":"Cleveland-Akron (Canton), OH","type_value":"post"},{"lat_value":"44.5133188","lon_value":"-88.0132958","count_value":"4","marker_size_value":"1","geohash_value":false,"name_value":"Green Bay-Appleton, WI","type_value":"post"},{"lat_value":"42.732535","lon_value":"-84.5555347","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Lansing, MI","type_value":"post"},{"lat_value":"41.2565369","lon_value":"-95.9345034","count_value":"19","marker_size_value":"3","geohash_value":false,"name_value":"Omaha, NE","type_value":"post"},{"lat_value":"35.612661","lon_value":"-77.3663538","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Greenville-New Bern-Washington, NC","type_value":"post"},{"lat_value":"38.5815719","lon_value":"-121.4943996","count_value":"14","marker_size_value":"3","geohash_value":false,"name_value":"Sacramento-Stockton-Modesto, CA","type_value":"post"},{"lat_value":"43.6590993","lon_value":"-70.2568189","count_value":"6","marker_size_value":"2","geohash_value":false,"name_value":"Portland-Auburn, ME","type_value":"post"},{"lat_value":"37.6871761","lon_value":"-97.330053","count_value":"34","marker_size_value":"3","geohash_value":false,"name_value":"Wichita-Hutchinson, KS Plus","type_value":"post"},{"lat_value":"33.4956744","lon_value":"-88.4272627","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Columbus-Tupelo-West Point, MS","type_value":"post"},{"lat_value":"43.5473028","lon_value":"-96.728333","count_value":"8","marker_size_value":"2","geohash_value":false,"name_value":"Sioux Falls (Mitchell), SD","type_value":"post"},{"lat_value":"42.6525793","lon_value":"-73.7562317","count_value":"7","marker_size_value":"2","geohash_value":false,"name_value":"Albany-Schenectady-Troy, NY","type_value":"post"},{"lat_value":"43.5427278","lon_value":"-111.8431068","count_value":"8","marker_size_value":"2","geohash_value":false,"name_value":"Idaho Falls-Pocatello, ID","type_value":"post"},{"lat_value":"38.9071923","lon_value":"-77.0368707","count_value":"438","marker_size_value":"3","geohash_value":false,"name_value":"Washington, DC (Hagerstown, MD)","type_value":"post"},{"lat_value":"43.8137751","lon_value":"-91.2519017","count_value":"8","marker_size_value":"2","geohash_value":false,"name_value":"La Crosse-Eau Claire, WI","type_value":"post"},{"lat_value":"38.9517053","lon_value":"-92.3340724","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Columbia-Jefferson City, MO","type_value":"post"},{"lat_value":"36.9685219","lon_value":"-86.4808043","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Bowling Green, KY","type_value":"post"},{"lat_value":"42.3600825","lon_value":"-71.0588801","count_value":"50","marker_size_value":"3","geohash_value":false,"name_value":"Boston, MA (Manchester, NH)","type_value":"post"},{"lat_value":"22.096424102783","lon_value":"-159.52629089355","count_value":"1","marker_size_value":"1","geohash_value":"87yt9ys9","name_value":false,"type_value":"event"},{"lat_value":"39.9611755","lon_value":"-82.9987942","count_value":"19","marker_size_value":"3","geohash_value":false,"name_value":"Columbus, OH","type_value":"post"},{"lat_value":"44.0121221","lon_value":"-92.4801989","count_value":"8","marker_size_value":"2","geohash_value":false,"name_value":"Rochester, MN-Mason City, IA-Austin, MN","type_value":"post"},{"lat_value":"37.0833893","lon_value":"-88.6000478","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Paducah, KY-Cape Girardeau, MO-Harrisburg, IL","type_value":"post"},{"lat_value":"32.8406946","lon_value":"-83.6324022","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Macon, GA","type_value":"post"},{"lat_value":"42.4963416","lon_value":"-96.4049408","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Sioux City, IA","type_value":"post"},{"lat_value":"44.977753","lon_value":"-93.2650108","count_value":"43","marker_size_value":"3","geohash_value":false,"name_value":"Minneapolis-St. Paul, MN","type_value":"post"},{"lat_value":"36.0726354","lon_value":"-79.7919754","count_value":"6","marker_size_value":"2","geohash_value":false,"name_value":"Greensboro-High Point-Winston Salem, NC","type_value":"post"},{"lat_value":"42.258567810059","lon_value":"-87.840843200684","count_value":"1","marker_size_value":"1","geohash_value":"dp983huq","name_value":false,"type_value":"event"},{"lat_value":"45.7832856","lon_value":"-108.5006904","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Billings, MT","type_value":"post"},{"lat_value":"35.7795897","lon_value":"-78.6381787","count_value":"59","marker_size_value":"3","geohash_value":false,"name_value":"Raleigh-Durham (Fayetteville), NC","type_value":"post"},{"lat_value":"39.5296329","lon_value":"-119.8138027","count_value":"5","marker_size_value":"1","geohash_value":false,"name_value":"Reno, NV","type_value":"post"},{"lat_value":"31.5785074","lon_value":"-84.155741","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Albany, GA","type_value":"post"},{"lat_value":"30.4382559","lon_value":"-84.2807329","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Tallahassee, FL-Thomasville, GA","type_value":"post"},{"lat_value":"32.7766642","lon_value":"-96.7969879","count_value":"127","marker_size_value":"3","geohash_value":false,"name_value":"Dallas-Ft. Worth, TX","type_value":"post"},{"lat_value":"39.1031182","lon_value":"-84.5120196","count_value":"15","marker_size_value":"3","geohash_value":false,"name_value":"Cincinnati, OH","type_value":"post"},{"lat_value":"33.9137085","lon_value":"-98.4933873","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Wichita Falls, TX-Lawton, OK","type_value":"post"},{"lat_value":"42.8864468","lon_value":"-78.8783689","count_value":"18","marker_size_value":"3","geohash_value":false,"name_value":"Buffalo, NY","type_value":"post"},{"lat_value":"32.5093109","lon_value":"-92.1193012","count_value":"24","marker_size_value":"3","geohash_value":false,"name_value":"Monroe, LA-El Dorado, AR","type_value":"post"},{"lat_value":"33.5185892","lon_value":"-86.8103567","count_value":"7","marker_size_value":"2","geohash_value":false,"name_value":"Birmingham (Anniston and Tuscaloosa), AL","type_value":"post"},{"lat_value":"33.4483771","lon_value":"-112.0740373","count_value":"56","marker_size_value":"3","geohash_value":false,"name_value":"Phoenix, AZ","type_value":"post"},{"lat_value":"40.7127753","lon_value":"-74.0059728","count_value":"134","marker_size_value":"3","geohash_value":false,"name_value":"New York, NY","type_value":"post"},{"lat_value":"39.2903848","lon_value":"-76.6121893","count_value":"42","marker_size_value":"3","geohash_value":false,"name_value":"Baltimore, MD","type_value":"post"},{"lat_value":"30.267153","lon_value":"-97.7430608","count_value":"15","marker_size_value":"3","geohash_value":false,"name_value":"Austin, TX","type_value":"post"},{"lat_value":"39.7284944","lon_value":"-121.8374777","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Chico-Redding, CA","type_value":"post"},{"lat_value":"31.7618778","lon_value":"-106.4850217","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"El Paso, TX","type_value":"post"},{"lat_value":"40.6936488","lon_value":"-89.5889864","count_value":"33","marker_size_value":"3","geohash_value":false,"name_value":"Peoria-Bloomington, IL","type_value":"post"},{"lat_value":"41.7658043","lon_value":"-72.6733723","count_value":"37","marker_size_value":"3","geohash_value":false,"name_value":"Hartford \u0026 New Haven, CT","type_value":"post"},{"lat_value":"32.3512601","lon_value":"-95.3010624","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Tyler-Longview(Lufkin \u0026 Nacogdoches), TX","type_value":"post"},{"lat_value":"33.748970031738","lon_value":"-84.388046264648","count_value":"2","marker_size_value":"1","geohash_value":"djgzzxyd","name_value":false,"type_value":"event"},{"lat_value":"38.4495688","lon_value":"-78.8689155","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Harrisonburg, VA","type_value":"post"},{"lat_value":"41.5868353","lon_value":"-93.6249593","count_value":"22","marker_size_value":"3","geohash_value":false,"name_value":"Des Moines-Ames, IA","type_value":"post"},{"lat_value":"33.5778631","lon_value":"-101.8551665","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Lubbock, TX","type_value":"post"},{"lat_value":"26.640628","lon_value":"-81.8723084","count_value":"4","marker_size_value":"1","geohash_value":false,"name_value":"Ft. Myers-Naples, FL","type_value":"post"},{"lat_value":"42.44722366333","lon_value":"-71.22745513916","count_value":"1","marker_size_value":"1","geohash_value":"drt37pmc","name_value":false,"type_value":"event"},{"lat_value":"32.2987573","lon_value":"-90.1848103","count_value":"12","marker_size_value":"3","geohash_value":false,"name_value":"Jackson, MS","type_value":"post"},{"lat_value":"33.8302961","lon_value":"-116.5452921","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Palm Springs, CA","type_value":"post"},{"lat_value":"35.2219971","lon_value":"-101.8312969","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Amarillo, TX","type_value":"post"},{"lat_value":"42.1292241","lon_value":"-80.085059","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Erie, PA","type_value":"post"},{"lat_value":"44.0520691","lon_value":"-123.0867536","count_value":"4","marker_size_value":"1","geohash_value":false,"name_value":"Eugene, OR","type_value":"post"},{"lat_value":"35.1495343","lon_value":"-90.0489801","count_value":"12","marker_size_value":"3","geohash_value":false,"name_value":"Memphis, TN","type_value":"post"},{"lat_value":"39.7589478","lon_value":"-84.1916069","count_value":"9","marker_size_value":"2","geohash_value":false,"name_value":"Dayton, OH","type_value":"post"},{"lat_value":"36.1699412","lon_value":"-115.1398296","count_value":"17","marker_size_value":"3","geohash_value":false,"name_value":"Las Vegas, NV","type_value":"post"},{"lat_value":"40.742551","lon_value":"-84.1052256","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Lima, OH","type_value":"post"},{"lat_value":"40.7607793","lon_value":"-111.8910474","count_value":"36","marker_size_value":"3","geohash_value":false,"name_value":"Salt Lake City, UT","type_value":"post"},{"lat_value":"40.0639616","lon_value":"-80.7209149","count_value":"4","marker_size_value":"1","geohash_value":false,"name_value":"Wheeling, WV-Steubenville, OH","type_value":"post"},{"lat_value":"46.8771863","lon_value":"-96.7898034","count_value":"11","marker_size_value":"3","geohash_value":false,"name_value":"Fargo-Valley City, ND","type_value":"post"},{"lat_value":"27.8005828","lon_value":"-97.396381","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Corpus Christi, TX","type_value":"post"},{"lat_value":"34.0522342","lon_value":"-118.2436849","count_value":"73","marker_size_value":"3","geohash_value":false,"name_value":"Los Angeles, CA","type_value":"post"},{"lat_value":"34.2103894","lon_value":"-77.8868117","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Wilmington, NC","type_value":"post"},{"lat_value":"42.331352233887","lon_value":"-83.045997619629","count_value":"1","marker_size_value":"1","geohash_value":"dpsby4py","name_value":false,"type_value":"event"},{"lat_value":"43.100903","lon_value":"-75.232664","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Utica, NY","type_value":"post"},{"lat_value":"27.950575","lon_value":"-82.4571776","count_value":"80","marker_size_value":"3","geohash_value":false,"name_value":"Tampa-St. Petersburg (Sarasota), FL","type_value":"post"},{"lat_value":"41.6528052","lon_value":"-83.5378674","count_value":"8","marker_size_value":"2","geohash_value":false,"name_value":"Toledo, OH","type_value":"post"},{"lat_value":"34.7464809","lon_value":"-92.2895948","count_value":"7","marker_size_value":"2","geohash_value":false,"name_value":"Little Rock-Pine Bluff, AR","type_value":"post"},{"lat_value":"41.079273","lon_value":"-85.1393513","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Ft. Wayne, IN","type_value":"post"},{"lat_value":"39.2667418","lon_value":"-81.5615135","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Parkersburg, WV","type_value":"post"},{"lat_value":"37.7749295","lon_value":"-122.4194155","count_value":"41","marker_size_value":"3","geohash_value":false,"name_value":"San Francisco-Oakland-San Jose, CA","type_value":"post"},{"lat_value":"39.768403","lon_value":"-86.158068","count_value":"40","marker_size_value":"3","geohash_value":false,"name_value":"Indianapolis, IN","type_value":"post"},{"lat_value":"42.331427","lon_value":"-83.0457538","count_value":"30","marker_size_value":"3","geohash_value":false,"name_value":"Detroit, MI","type_value":"post"},{"lat_value":"25.7616798","lon_value":"-80.1917902","count_value":"27","marker_size_value":"3","geohash_value":false,"name_value":"Miami-Fort Lauderdale, FL","type_value":"post"},{"lat_value":"38.3498195","lon_value":"-81.6326234","count_value":"4","marker_size_value":"1","geohash_value":false,"name_value":"Charleston-Huntington, WV","type_value":"post"},{"lat_value":"30.080174","lon_value":"-94.1265562","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Beaumont-Port Arthur, TX","type_value":"post"},{"lat_value":"38.3606736","lon_value":"-75.5993692","count_value":"19","marker_size_value":"3","geohash_value":false,"name_value":"Salisbury, MD","type_value":"post"},{"lat_value":"39.9525839","lon_value":"-75.1652215","count_value":"80","marker_size_value":"3","geohash_value":false,"name_value":"Philadelphia, PA","type_value":"post"},{"lat_value":"32.0808989","lon_value":"-81.091203","count_value":"5","marker_size_value":"1","geohash_value":false,"name_value":"Savannah, GA","type_value":"post"},{"lat_value":"45.5122308","lon_value":"-122.6587185","count_value":"37","marker_size_value":"3","geohash_value":false,"name_value":"Portland, OR","type_value":"post"},{"lat_value":"32.5251516","lon_value":"-93.7501789","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Shreveport, LA","type_value":"post"},{"lat_value":"37.2698395","lon_value":"-81.2223195","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Bluefield-Beckley-Oak Hill, WV","type_value":"post"},{"lat_value":"30.1588129","lon_value":"-85.6602058","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Panama City, FL","type_value":"post"},{"lat_value":"34.924850463867","lon_value":"-81.025199890137","count_value":"3","marker_size_value":"1","geohash_value":"dnnqsjzk","name_value":false,"type_value":"event"},{"lat_value":"35.9606384","lon_value":"-83.9207392","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Knoxville, TN","type_value":"post"},{"lat_value":"35.4675602","lon_value":"-97.5164276","count_value":"21","marker_size_value":"3","geohash_value":false,"name_value":"Oklahoma City, OK","type_value":"post"},{"lat_value":"38.8338816","lon_value":"-104.8213634","count_value":"4","marker_size_value":"1","geohash_value":false,"name_value":"Colorado Springs-Pueblo, CO","type_value":"post"},{"lat_value":"26.7153424","lon_value":"-80.0533746","count_value":"7","marker_size_value":"2","geohash_value":false,"name_value":"West Palm Beach-Ft. Pierce, FL","type_value":"post"},{"lat_value":"28.5383355","lon_value":"-81.3792365","count_value":"25","marker_size_value":"3","geohash_value":false,"name_value":"Orlando-Daytona Beach-Melbourne, FL","type_value":"post"},{"lat_value":"43.6150186","lon_value":"-116.2023137","count_value":"23","marker_size_value":"3","geohash_value":false,"name_value":"Boise, ID","type_value":"post"},{"lat_value":"38.6270025","lon_value":"-90.1994042","count_value":"35","marker_size_value":"3","geohash_value":false,"name_value":"St. Louis, MO","type_value":"post"},{"lat_value":"37.2709704","lon_value":"-79.9414266","count_value":"10","marker_size_value":"3","geohash_value":false,"name_value":"Roanoke-Lynchburg, VA","type_value":"post"},{"lat_value":"32.715738","lon_value":"-117.1610838","count_value":"32","marker_size_value":"3","geohash_value":false,"name_value":"San Diego, CA","type_value":"post"},{"lat_value":"35.2270869","lon_value":"-80.8431267","count_value":"23","marker_size_value":"3","geohash_value":false,"name_value":"Charlotte, NC","type_value":"post"},{"lat_value":"33.6890603","lon_value":"-78.8866943","count_value":"3","marker_size_value":"1","geohash_value":false,"name_value":"Myrtle Beach-Florence, SC","type_value":"post"},{"lat_value":"40.4167022","lon_value":"-86.8752869","count_value":"1","marker_size_value":"1","geohash_value":false,"name_value":"Lafayette, IN","type_value":"post"},{"lat_value":"46.6020711","lon_value":"-120.5058987","count_value":"2","marker_size_value":"1","geohash_value":false,"name_value":"Yakima-Pasco-Richland-Kennewick, WA","type_value":"post"},{"lat_value":"39.7392358","lon_value":"-104.990251","count_value":"48","marker_size_value":"3","geohash_value":false,"name_value":"Denver, CO","type_value":"post"},{"lat_value":"32.2226066","lon_value":"-110.9747108","count_value":"16","marker_size_value":"3","geohash_value":false,"name_value":"Tucson (Sierra Vista), AZ","type_value":"post"},{"lat_value":"41.8781136","lon_value":"-87.6297982","count_value":"122","marker_size_value":"3","geohash_value":false,"name_value":"Chicago, IL","type_value":"post"}]}},"user":{"uid":0,"permissionsHash":"491b77d40f6283df569657d63f3c0d8a9d5e14a26f11b80e0b78bb88da676cba"}}</script>
<script src="/core/assets/vendor/jquery/jquery.min.js?v=3.7.0"></script>
<script src="/core/assets/vendor/once/once.min.js?v=1.0.1"></script>
<script src="/core/misc/drupalSettingsLoader.js?v=10.1.5"></script>
<script src="/core/misc/drupal.js?v=10.1.5"></script>
<script src="/core/misc/drupal.init.js?v=10.1.5"></script>
<script src="/core/misc/debounce.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/version-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/data-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/disable-selection-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/form-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/jquery-patch-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/scroll-parent-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/unique-id-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/focusable-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/ie-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/keycode-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/plugin-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/safe-active-element-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/safe-blur-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/widget-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/labels-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/widgets/controlgroup-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/form-reset-mixin-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/widgets/mouse-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/widgets/checkboxradio-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/widgets/draggable-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/widgets/resizable-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/widgets/button-min.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery.ui/ui/widgets/dialog-min.js?v=10.1.5"></script>
<script src="/modules/contrib/blazy/js/dblazy.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/plugin/blazy.dataset.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/plugin/blazy.viewport.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/plugin/blazy.dom.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/plugin/blazy.xlazy.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/plugin/blazy.observer.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/plugin/blazy.loading.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/base/blazy.base.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/base/io/bio.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/base/io/bio.media.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/base/blazy.drupal.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/blazy.load.min.js?sb60d1"></script>
<script src="/modules/contrib/blazy/js/blazy.compat.min.js?sb60d1"></script>
<script src="/core/assets/vendor/tabbable/index.umd.min.js?v=6.1.2"></script>
<script src="https://static.addtoany.com/menu/page.js" async></script>
<script src="/modules/contrib/addtoany/js/addtoany.js?v=10.1.5"></script>
<script src="/modules/contrib/entity_embed/js/entity_embed.set_dynamic_icons.js?sb60d1"></script>
<script src="/core/assets/vendor/ckeditor5/ckeditor5-dll/ckeditor5-dll.js?v=39.0.1"></script>
<script src="/themes/custom/nhlbi/assets/uswds/dist/js/uswds-init.min.js?v=3.1.0"></script>
<script src="/themes/custom/nhlbi/assets/uswds/dist/js/uswds.min.js?v=3.1.0"></script>
<script src="/core/assets/vendor/js-cookie/js.cookie.min.js?v=3.0.5"></script>
<script src="/themes/custom/nhlbi/js/component_load_more.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/script.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/textsizer.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/jquery.simplemodal.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/jquery-migrate-3.0.0.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/jquery-ui.min.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/jQuery.print.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/ck_entity_embed.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/stacktable.min.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/smoothscroll.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/view_more_pager.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/banner_promotion.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/nhlbi_catalog_pubs.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/nhlbi-ourhearts-datepicker.js?v=15.2"></script>
<script src="/themes/custom/nhlbi/js/alerts.js?v=15.2"></script>
<script src="/modules/custom/nih_extlink/nih_extlink.js?v=10.1.5"></script>
<script src="/core/misc/progress.js?v=10.1.5"></script>
<script src="/core/assets/vendor/loadjs/loadjs.min.js?v=4.2.0"></script>
<script src="/core/misc/announce.js?v=10.1.5"></script>
<script src="/core/misc/message.js?v=10.1.5"></script>
<script src="/core/misc/ajax.js?v=10.1.5"></script>
<script src="/modules/contrib/blazy/js/base/io/bio.ajax.min.js?sb60d1"></script>
<script src="/modules/contrib/views_ajax_history/js/views_ajax_history.js?v=10.1.5"></script>
<script src="/core/assets/vendor/jquery-form/jquery.form.min.js?v=4.3.0"></script>
<script src="/core/modules/views/js/base.js?v=10.1.5"></script>
<script src="/core/modules/views/js/ajax_view.js?v=10.1.5"></script>
<script src="/themes/custom/nhlbi/js/accordions.js?v=1.x"></script>
<script src="/themes/custom/nhlbi/js/read_more.js?v=1.x"></script>
<script src="/themes/custom/nhlbi/js/nhlbi_print_modal.js?v=1.x"></script>
<script src="/core/misc/displace.js?v=10.1.5"></script>
<script src="/core/misc/jquery.tabbable.shim.js?v=10.1.5"></script>
<script src="/core/misc/position.js?v=10.1.5"></script>
<script src="/core/misc/dialog/dialog.js?v=10.1.5"></script>
<script src="/core/misc/dialog/dialog.position.js?v=10.1.5"></script>
<script src="/core/misc/dialog/dialog.jquery-ui.js?v=10.1.5"></script>
<script src="/core/modules/ckeditor5/js/ckeditor5.dialog.fix.js?v=10.1.5"></script>


        <script async="" type="text/javascript" id="_fed_an_ua_tag" src="https://dap.digitalgov.gov/Universal-Federated-Analytics-Min.js?agency=HHS&sdor=nih.gov"></script>
  </body>
</html>