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		Search Text: Clinical Trials
					
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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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Clear AllCystic Fibrosis
Showing 1 - 9 out of 9 results
      
      Immune Correlates of Cardiac Structure and Function
      Recruiting
                          North Carolina
        The purpose of this study is to determine the occurrence of scarring of the heart (cardiac fibrosis) and inflammation in those with perinatally acquired Human Immunodeficiency Virus (HIV) infection compared to people not infected with HIV. The information learned from this research may help the investigator to better understand the link between cardiac fibrosis and cardiac dysfunction and inflammation in those with perinatally acquired HIV infection compared to the uninfected.
      Cystic Fibrosis
              Heart Tests
                          Adult
    Fibrosis and the Fontan
      Recruiting
                          Pennsylvania
        The purpose of this study is to non-invasively characterize the fibrotic consequences of single ventricle physiology, its possible solution and effect on lymphatics. This project investigates the response to acute imposition of Fontan hemodynamics by examining the interrelationship between liver and cardiac fibrosis/dysfunction and lymphatic congestion along with a pilot trial of the antifibrotic agent, spironolactone, to prevent these consequences and to determine if MRI can discern these differences. The combination of serum biomarkers and MRI form a powerful non-invasive tool in putting together this complicated web of dysfunction.
      Cystic Fibrosis
                          Child
    Regadenoson Infusion of Marginalized Donor Lungs in an EVLP System
      Recruiting
                          Maryland
              Ohio
        The purpose of this study is to see if adding a drug called Regadenoson to the EVLP circulation reservoir during perfusion of marginal donor lungs will help increase the likelihood that the donor lungs will become usable for transplantation.
      Idiopathic Pulmonary Fibrosis
              Cystic Fibrosis
              Interstitial Lung Diseases
              Lung Disease Treatments
                          Adult, Older Adult
    Nasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis
      Recruiting
                          Alabama
        The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms underlying Chronic Rhinosinusitis (CRS), creating a localized environment that impairs mucociliary clearance (MCC).
      Cystic Fibrosis
                          Adult, Older Adult
    Health Outcomes of Parents With Cystic Fibrosis
      Recruiting
                          Multiple Locations
        This project will determine the health impact of parenthood on people with cystic fibrosis (CF). The study team will use retrospective data to provide relatively immediate evidence on parenthood's effect on pulmonary health.
      Cystic Fibrosis
                          Adult, Older Adult
    Quantitation and Spatial Registration of Airways Dysfunction With Dynamic 19F MRI in Cystic Fibrosis
      Recruiting
                          North Carolina
        The purpose of this study is to look at lung ventilation in people with cystic fibrosis over time (1 year) using magnetic resonance imaging (MRI) with an inhaled contrast gas, and compare these measures to lung function assessed by spirometry and multiple breath nitrogen washout. This study also looks at how these measures change in response to a pulmonary exacerbation and treatment (if applicable). Over the span of a year, participants would be asked to complete 3-5 visits to the University of North Carolina at Chapel Hill (UNC). with each lasting up to 4 hours. If participants do not have a pulmonary exacerbation during the year they would be asked to complete 3 visits (one at enrollment, a second roughly 2 weeks later, and the third approximately a year later). If participants do experience a CF pulmonary exacerbation they would complete 5 visits (Visit 1, Visit 2, two exacerbation visits with one before treatment and the other after, and Visit 3 at one year after Visit 1). Only one exacerbation per participant will be tracked. Participants are eligible for this study if they are 18 years old or older, have Cystic Fibrosis (CF) with mild lung disease (FEV1 >/= 60%), and can undergo an MRI. There are no known benefits for participating in this study.
      Cystic Fibrosis
                          Adult, Older Adult
    Role of Genetic Factors in the Development of Lung Disease
      Recruiting
                          Maryland
        Do you or your child have a lung disease? This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old. This study is located in Bethesda, Maryland, at the NIH Clinical Center.
      Asthma
              COPD
              Cystic Fibrosis
              Alpha-1 Antitrypsin Deficiency
                          All Ages
                                      Accepting Healthy Volunteers
    Mapping Chemical and Microbiological Heterogeneity Throughout Explanted Cystic Fibrosis Lung Specimens
      Recruiting
                          Minnesota
        Do you have cystic fibrosis and are you eligible for a lung transplant?
                    This study is interested in learning more about the presence and location of certain bacteria in the lungs of people who have cystic fibrosis by examining lungs that have been removed from patients who have cystic fibrosis who are undergoing a lung transplant. To participate in this study, you must be at least 18 years old, have been diagnosed with cystic fibrosis, be eligible for a lung transplant, and have tried all other available treatments without success. This study is located in Minneapolis, Minnesota.
      Cystic Fibrosis
                          Adult, Older Adult
    Multilevel Models of Therapeutic Response in the Lungs
      Recruiting
                          Pennsylvania
        Do you want to participate in a study with your child who has cystic fibrosis?
                    This study is exploring computer models to compare cell samples from the noses of people who have cystic fibrosis, their parents, and other healthy individuals in hopes of better predicting how patients will respond to medicine. These computer models may allow medicines to be developed more rapidly and better predict who will respond to a certain cystic fibrosis treatment. To participate in this study, you must fall into one of the following groups: (1) have cystic fibrosis and be at least 12 years old, (2) be the biological parent of a cystic fibrosis patient enrolled in the study and be at least 18 years old, or (3) have no history of lung disease and be at least 18 years old. This study is located in Pittsburgh, Pennsylvania.
      Cystic Fibrosis
                          All Ages
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