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		Search Text: Home/< Back ToThe Science/DNA Sequencing and Genomics Core
  DNA Sequencing and Genomics Core
    The DNA Sequencing and Genomics Core provides NHLBI investigators with fast and cost-effective next-generation sequencing services to facilitate DIR basic and translational research.
    On This Page
    
          Yuesheng Li
  Yuesheng Li, Ph.D.
          Core Director
          Email
      Meet the Team
            Contact us
  
  Research

            The DNA Sequencing and Computational Biology Core (DSGC) was established in 2010 to meet the increasing demands of NHLBI investigators for next-generation sequencing. The main goal of the DSGC is to foster large-scale genomics research at DIR by providing access to cutting-edge sequencing instrumentation and genome technology. As an integral part of the research community at NHLBI, the DSGC provides standard and advanced services for experimental consultation, data acquisition and computational analysis.
Featured Publications
                A homozygous PMS2 founder mutation with an attenuated constitutional mismatch repair deficiency phenotype.
            Authors:Li L, Hamel N, Baker K, McGuffin MJ, Couillard M, Gologan A, Marcus VA, Chodirker B, Chudley A, Stefanovici C, Durandy A, Hegele RA, Feng BJ, Goldgar DE, Zhu J, De Rosa M, Gruber SB, Wimmer K, Young B, Chong G, Tischkowitz MD, Foulkes WD
                                    
            J Med Genet
      
                2015 Apr 13
        Read Publication
                      Glucocorticoid-resistant Th17 cells are selectively attenuated by cyclosporine A.
            Authors:Schewitz-Bowers LP, Lait PJ, Copland DA, Chen P, Wu W, Dhanda AD, Vistica BP, Williams EL, Liu B, Jawad S, Li Z, Tucker W, Hirani S, Wakabayashi Y, Zhu J, Sen N, Conway-Campbell BL, Gery I, Dick AD, Wei L, Nussenblatt RB, Lee RW
                                                                                                                        
            Proc Natl Acad Sci U S A
      
                2015 Mar 31;112(13):4080-5
        Read Publication
                      miR-501-3p mediates the activity-dependent regulation of the expression of AMPA receptor subunit GluA1.
            Authors:Hu Z, Zhao J, Hu T, Luo Y, Zhu J, Li Z
                                                                                                                        
            J Cell Biol
      
                2015 Mar 30;208(7):949-59
        Read Publication
                      A Liver-Enriched Long Non-Coding RNA, lncLSTR, Regulates Systemic Lipid Metabolism in Mice.
            Authors:Li P, Ruan X, Yang L, Kiesewetter K, Zhao Y, Luo H, Chen Y, Gucek M, Zhu J, Cao H
                                                                                                                        
            Cell Metab
      
                2015 Mar 03;21(3):455-67
        Read Publication
                      A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension.
            Authors:Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, Chen BH, Liu C, Joehanes R, Johnson AD, Yao C, Ying SX, Courchesne P, Milani L, Raghavachari N, Wang R, Liu P, Reinmaa E, Dehghan A, Hofman A, Uitterlinden AG, Hernandez DG, et. al
                                                                                                                        
            PLoS Genet
      
                2015 Mar 01;11(3):e1005035
        Read Publication
  Meet the Team

    Yuesheng Li

            Yuesheng Li, Ph.D.
                Core Director
                Yuesheng Li, Ph.D., is the director of the DNA Sequencing and Genomics Core Facility at the NHLBI.
    
          Contact the lab
    10 Center DrBethesda, MD 20814United States
        Phone:
                    301-594-8346
                Fax:
  Poching Liu
    
            Poching  Liu, Ph.D.
        

    Scientific Support Staff

        pcliu@mail.nih.gov
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            Yan  Luo, Ph.D.
        

    Scientific Support Staff

        luoy3@mail.nih.gov Back To Top Link
  

        

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