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		Search Text: Clinical Trials
					
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            The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find studies for diseases and conditions and see if you or a loved one is eligible.
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      How Clinical Trials Work
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      Who Can Participate
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      Benefits, Risks & Safety Measures
Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
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CLEARAcute Respiratory Distress SyndromeAlpha-1 Antitrypsin DeficiencyAnemiaAngina (Chest Pain)Aortic AneurysmAplastic AnemiaArrhythmiasAsthmaAtherosclerosisAtrial FibrillationBleeding DisordersBlood CholesterolBlood Clotting DisordersBronchiectasisBronchitisCardiac ArrestCardiac CatheterizationCardiogenic ShockCardiomyopathyChildhood ObesityCircadian Rhythm DisordersConduction DisordersCongenital Heart DefectsCOPDCoronary Artery Bypass GraftingCoronary Heart DiseaseCystic FibrosisDeep Vein Thrombosis (DVT)DefibrillatorsGet Regular Physical ActivityHeart-Healthy LivingHeart AttackHeart FailureHeart InflammationHeart SurgeryHeart TestsHeart TransplantHeart TreatmentsHeart Valve DiseasesHemolytic AnemiaHigh Blood PressureHigh Blood TriglyceridesHow Sleep WorksHow the Heart WorksHow the Lungs WorkIdiopathic Pulmonary FibrosisInsomniaInterstitial Lung DiseasesLAMLong QT SyndromeLow Blood PressureLung Disease TreatmentsMarfan SyndromeMetabolic SyndromeNarcolepsyNewborn Breathing ConditionsOverweight and ObesityPacemakersPeripheral Artery DiseasePhysical Activity and Your HeartPlatelet DisordersPleural DisordersPneumoniaPolycythemia VeraPrimary Ciliary DyskinesiaPulmonary HypertensionPulmonary RehabilitationRespiratory FailureSarcoidosisSickle Cell DiseaseSleep ApneaSleep Deprivation and DeficiencySleep StudiesSmoking and Your HeartStrokeTests for Lung DiseaseThalassemiaThe LungsTranscatheter Aortic Valve Replacement (TAVR)Treatments for Blood DisordersVasculitisVenous ThromboembolismVentilator/Ventilator SupportWhat Is Physical Activity?Women and Heart Disease

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Showing 1 - 10 out of 404 results
      
      Controls and Healthy Vasculature Initiative
      Recruiting
                          Maryland
        Are you a healthy adult? In this clinical trial, researchers are trying to improve the quality of heart CT scans by using new methods to create the images. Researchers will take normal CT images of the heart and compare those images to super high-resolution images made with a super-computer. Healthy adults aged 18 years or older may be able to participate. The study is taking place at the NIH Clinical Center in Bethesda, Maryland.
      Deep Vein Thrombosis (DVT)
                          Adult, Older Adult
                                      Accepting Healthy Volunteers
    Prospective Evaluation of Next Generation CT Reconstruction (NextGenIR)
      Recruiting
                          Maryland
        Are you at least 18 years old and scheduled for a CT of the chest, abdomen, and pelvis?
                    In this study, researchers want to learn if new CT imaging methods with less radiation make images that are similar to traditional ways. If you are at least 18 and your doctor has said you need a CT scan of the chest, abdomen, or pelvis, you may be able to participate. This study is taking place at the National Institutes of Health Clinical Center in Bethesda, Maryland.
      The Lungs
              How the Lungs Work
              How the Heart Works
                          Adult, Older Adult
    Right Ventricle Lipid in Pulmonary Arterial Hypertension (PAH)
      Recruiting
                          Tennessee
        The investigators propose to study the relationship between right ventricle (RV) steatosis and RV function, exercise capacity, and outcomes in humans with pulmonary arterial hypertension (PAH) and to identify potential drivers of lipid accumulation.
      Pulmonary Hypertension
                          Adult, Older Adult
    Role of Sleep Reactivity in Shift Work Disorder
      Recruiting
                          Michigan
        The purpose of this project is to test sleep reactivity as an independent cause of Shift Work Disorder (SWD). The primary hypothesis is that those with high sleep reactivity will show persistent SWD symptoms after experimental reduction of circadian misalignment, which will then be mitigated with CBT.
      How Sleep Works
              Sleep Deprivation and Deficiency
              Sleep Studies
                          Adult, Older Adult
    Splanchnic Venous Capacitance in Postural Tachycardia Syndrome
      Recruiting
                          Tennessee
        The study is to investigate that the worsening orthostatic tachycardia and symptoms after glucose ingestion in POTS patients are due to a greater increase in splanchnic venous capacitance and excessive blood pooling during an orthostatic challenge.
      Heart Attack
                          Adult
                                      Accepting Healthy Volunteers
    RCT of Sensor-controlled Digital Game for Heart Failure Self-management
      Recruiting
                          Texas
        This study evaluates a sensor-controlled digital game (SCDG) to motivate self-management behaviors of weight monitoring and physical activity in adults with heart failure (HF). Half of the participants will receive the SCDG app and weight monitoring and physical activity sensors and the other half will receive only the weight monitoring and physical activity sensors.
      Heart Failure
              Physical Activity and Your Heart
                          Adult, Older Adult
    2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)
      Recruiting
                          Tennessee
        Do you have a family history of high cholesterol? Researchers are studying whether a particular medication can lower cholesterol in people with a family history of high cholesterol. You may be able to participate if you are 18 to 69 years old, have not had a heart attack or stroke recently, and do not have uncontrolled high blood pressure. This study will take place in Nashville, Tennessee.
      Blood Cholesterol
                          Adult, Older Adult
    Dietary Intervention to Mitigate Adverse Consequences of Night Work
      Recruiting
                          Massachusetts
        Shift work increases the risk for diabetes possibly due to the adverse metabolic effects of circadian misalignment. As shift work is not foreseen to disappear, the development of individually-targeted therapies for metabolic health in these vulnerable shift workers is urgently needed. This research will determine whether our dietary intervention can mitigate the adverse metabolic effects of circadian misalignment, which may help in the design of evidence-based dietary interventions to improve the metabolic health in shift workers.
      How Sleep Works
              Sleep Deprivation and Deficiency
              Sleep Studies
                          Adult
                                      Accepting Healthy Volunteers
    Survivor mHealth: Wearable Devices in Cancer Survivors
      Recruiting
                          Massachusetts
        Are you a cancer survivor? Would you like to join a clinical trial that is testing whether wearable devices and smartphone apps can help cancer survivors be more active? You must be 18 years old to join. The study is taking place in Worcester, Massachusetts.
      What Is Physical Activity?
              Physical Activity and Your Heart
                          Adult, Older Adult
                                      Accepting Healthy Volunteers
    Zinc Intervention in Elderly for Prevention of Pneumonia
      Recruiting
                          Massachusetts
        Pneumonia is a major public health problem for the elderly and is one of the leading causes of hospitalization and death for this population, particularly for elderly nursing home residents. This planning grants seeks to establish a safe and effective dose of zinc supplementation with the goal to conduct a larger randomized clinical trial to study the effect of zinc supplementation in nursing home elderly with low serum zinc levels on the risk, antibiotic use, and duration of sick days with pneumonia. This project has significant potential to positively impact the health and quality of life in the elderly and to reduce the economic costs associated with their care.
      Pneumonia
              Lung Disease Treatments
                          Older Adult
                                      Accepting Healthy Volunteers
  
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