U.S. flag

An official website of the United States government

Here’s how you know
Here’s how you know

**Official websites use .gov**
A **.gov** website belongs to an official government organization in the United States.

**Secure .gov websites use HTTPS**
A **lock** ( A locked padlock) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Search Query:
			MAIN MENU

																				
              Health Topics
								All Health Topics A-Z
					
													
		

		Asthma


				

															Heart-Healthy Living


				

															High Blood Pressure


				

															Sickle Cell Disease


				

															Sleep Apnea


				

															Information & Resources on COVID-19
																				
              Health Education
								Education Programs and Initiatives
					
													
		

		The Heart Truth®


				

															Learn More Breathe Better®


				

															Blood Diseases and Disorders Education Program


				

															Publications and Resources
																				
              The Science
								Research Focus Areas
					
													
		

		Blood Disorders and Blood Safety


				

															Sleep Science and Sleep Disorders


				

															Lung Diseases


				

															Health Disparities and Inequities


				

															Heart and Vascular Diseases


				

															Precision Medicine Activities


				

															Obesity, Nutrition, and Physical Activity


				

															Population and Epidemiology Studies


				

															Women’s Health


				

															Research Topics


				

															Clinical Trials


				

															All Science A-Z
																				
              Grants and Training
								Grants and Training Home


				

															Policies and Guidelines


				

															Funding Opportunities and Contacts


				

															Training and Career Development
																				
              News and Events
								News and Events Home
					
													
		

		Email Alerts


				

															All News
					
													
		

		NHLBI News


				

															NHLBI in the Press


				

															Research Features


				

															All Events
					
													
		

		Past Events


				

															Upcoming Events
																				
              About NHLBI
								About NHLBI Home
					
													
		

		Mission and Strategic Vision


				

															Leadership


				

															Divisions, Offices and Centers


				

															Advisory Committees


				

															Budget and Legislative Information


				

															Jobs and Working at the NHLBI


				

															Contact and FAQs


				

															NIH Sleep Research Plan
						
						HOME
		Search Text: Home/About the NHLBI/Strategic Vision/< Back ToStrategic Goals and Objectives/Identify factors that account for individual differences in pathobiology and in responses to treatments

Objective 4:  
Identify factors that account for individual differences in pathobiology and in responses to treatments
                Research advances in areas such as genomics and other “omics” (e.g., proteomics, metabolomics) have provided new opportunities to deepen our understanding of heart, lung, blood, and sleep (HLBS) pathobiological processes and how these vary among individual patients. Accelerating progress toward precise, individualized prevention efforts and medical interventions will require research into biological factors, environmental exposures, and other influences that account for differences in pathobiology and unique responses to treatment (including drug reactions and other adverse events). This research will allow personal and clinical decisions, practices, and medical products to be tailored to the individual patient to help optimize outcomes.
                        Envision a future in which we are able to...
      
                            
    Develop precise clinical interventions based on individual environmental exposures, behaviors, genotypes, and molecular-cellular phenotypes.
              Accelerate the incorporation of new imaging, omics, and sensor technologies with advanced data analytics to inform more precise clinical classification of chronic diseases (e.g., asthma, pulmonary fibrosis, chronic obstructive lung disease, heart failure) and thereby enable more accurate diagnosis and treatment.
    
                        Related Priorities
                        Compelling Question
                                                                                                    Which phenotypic, biomarker, and molecular characteristics predict outcome and, when applied in clinical studies, predict differential responses to therapy in individuals and in different populations with HLBS diseases? (4.CQ.01)
    Compelling Question
                                                                                                    What factors render individuals or populations subjected to the same exposures (e.g., diet, smoking, other environmental and social exposures) resilient or susceptible to disease? (4.CQ.02)
    Compelling Question
                                                                                                    What underlies secondary resilience, such that some people are protected from the complications of HLBS diseases? (4.CQ.03)
    Compelling Question
                                                                                                    Which patients benefit from rehabilitation treatments (e.g., cardiac, vascular, and pulmonary), and how can the benefits of rehabilitation treatments be sustained long term? (4.CQ.04)
    Compelling Question
                                                                                                    How does the pathobiology that underlies nonobstructive ischemic heart disease and the associated risks for acute coronary syndrome and early mortality differ between subpopulations, and what are the targets for treatment and prevention? (4.CQ.05)
  
      
Load more
                        Overarching ObjectivesUnderstand normal biological function and resilienceInvestigate newly discovered pathobiological mechanisms important to the onset and progression of HLBS diseasesInvestigate factors that account for differences in health among populationsIdentify factors that account for individual differences in pathobiology and in responses to treatmentsDevelop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseasesOptimize clinical and implementation research to improve health and reduce diseaseLeverage emerging opportunities in data science to open new frontiers in HLBS researchFurther develop, diversify, and sustain a scientific workforce capable of accomplishing the NHLBI’s mission Back To Top Link
  

        

        Back to top
  Web Policies & Notices
  

        

              Accessibility
                      No FEAR Act Data
                      Privacy Policy
                      Freedom of Information Act (FOIA)
                      HHS Vulnerability Disclosure
    
          Related Government Websites
  

        

              Health and Human Services
                      National Institutes of Health
                      Office of the Inspector General
                      USA.gov
    
          Stay Connected
    
      
            chat bubblesLive ChatLive Chat with us, Monday through Friday, 8:30 a.m. to 5:00 p.m. EST.envelopeGet Email AlertsReceive automatic alerts about NHLBI related news and highlights from across the Institute.
  Footer Bottom
  

        



Contact Us
                            Site Index
                            Jobs