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		Search Text: Home/< Back ToThe Science/Hemostasis and Platelet Biology
  Hemostasis and Platelet Biology
    Research in the Laboratory for Hemostasis and Platelet Biology, led by Dr. Andrew Johnson, focuses on understanding genetic and genomic underpinnings of this individual variability in therapeutically targeted CVD pathways.
    On This Page
    
          Johnson
  Andrew Johnson, Ph.D.
          Investigator
          Email
                                      Profile
      Meet the Team
            Contact us
  Senior Investigator Research Interests
            
  Research Interests
              Cardiovascular disease (CVD) has a complex etiology, and CVD patients show a wide range of responses to therapeutic interventions. Dr. Johnson’s laboratory research focuses on understanding genetic and genomic underpinnings of this individual variability in therapeutically targeted CVD pathways. In particular, his work focuses on understanding individual variability in platelet development, function, and response to treatment. Drugs that decrease platelet reactivity, such as aspirin, are commonly used to reduce the risks of cardiovascular events such as myocardial infarction. Dr. Johnson is interested in the pharmacogenetics of anti-platelet treatments and resulting CVD outcomes. His laboratory applies population-scale approaches to the problem including genetic studies, collaboration with clinician-scientists, studies of gene expression variability in human tissues, and bioinformatics and systems biology approaches. His group makes particular use of the Framingham Heart Study and the rich amount of epidemiologic and genetic data it has accumulated over the years.

Additionally, the Johnson laboratory creates and applies cutting edge genomic and bioinformatics resources. In addition to advancing the goals of his research group and others at the NHLBI, these resources are be made freely available to benefit the wider scientific community, and help advance our understanding of CVD variability. To date these resources include SNAP (SNP Annotation and Proxy Search: http://www.broadinstitute.org/mpg/snap/), a fast human linkage disequilibrium query and annotation interface for worldwide population genetic samples, retired around 2016 with >4 million uses and >1,350 academic citations; GRASP (Genome-wide Repository of Associations between SNPs and Phenotypes), one of the largest and deepest databases of human genetic associations with >750 academic citations; and the COVID-19 public GWAS portal (Thibord et al., 2022).
  Featured Publications
                Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
            Authors:Bick AG, Weinstock JS, Nandakumar SK, Fulco...ohnson AD; NHLBI Trans-Omics for Precision Medicine Consortium...
                                                                                                                        
            Nature.
      
                2021 Oct 01;586(7831):763-768
        Read Publication
                      Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
            Authors:Bick AG, Weinstock JS,...Johnson AD; NHLBI Trans-Omics for Precision Medicine Consortium...
                                                                                            
            Nature.
      
                2021 Mar 11;Online ahead of print:
        Read Publication
                      Transcriptional profile of platelets and iPSC-derived megakaryocytes from whole-genome and RNA sequencing.
            Authors:Kammers K, Taub MA, Rodriguez B, Yanek LR, Ruczinski I, Martin J, Kanchan K, Battle A, Cheng L, Wang ZZ, Johnson AD, Leek JT, Faraday N, Becker LC, Mathias RA.
                                                                                                                        
            Blood.
      
                2021 Feb 18;137(7):959-968
        Read Publication
                      Genome-wide transcriptome study using deep RNA sequencing for myocardial infarction and coronary artery calcification.
            Authors:Zhang X, van Rooij JGJ, Wakabayashi Y, Hwang SJ, Yang Y, Ghanbari M, Bos D; BIOS Consortium, Levy D, Johnson AD, van Meurs JBJ, Kavousi M, Zhu J, O'Donnell CJ.
                                                                                                                        
            BMC Med Genomics.
      
                2021 Feb 10;14(1):45
        Read Publication
                      Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.
            Authors:Taliun D, Harris DN, Kessler MD,...Johnson AD, Kaplan R, Kardia SLR, Kelly T, Kelly S...
                                                                                                                        
            Nature.
      
                2021 Feb 01;590(7845):290-299
        Read Publication
                                View More Publications
  Meet the Team

    Johnson

            Andrew Johnson, Ph.D.
                Investigator
                Andrew Johnson earned a B.S. in vertebrate physiology from the Pennsylvania State University in 1998. He subsequently worked on gene regulatory research in C. elegans and neuroelectrophysiology in rodents before entering graduate school in 2003. He earned a Ph.D. in biomedical sciences from Ohio State University in 2007 with dual emphases in bioinformatics and pharmacogenomics. He came to the NIH for post-doctoral training in 2007, became a tenure track investigator in 2012 and was promoted to a tenured Senior Investigator in 2019. Dr. Johnson has been nominated for and received numerous awards including the NHLBI Lenfant Fellowship, the NHLBI Orloff Science Award, the CHARGE Consortium Early Career Investigator Award and Genome Technology’s Young Investigator Award, and was elected as a Fellow of the American Heart Association. He has published more than 210 papers and has served as a reviewer for more than 65 journals. His full publication record is found on NCBI. Dr. Johnson has served on numerous committees of the Framingham Heart Study, the American Heart Association, and the International Society for Thrombosis and Haemostasis. He currently chairs the NHLBI TOPMed Hematology and Hemostasis Working Group and the Framingham Heart Study Genetic Steering Committee. He is also a member of the American Society for Human Genetics, the International Society for Computational Biology and the International Society for Thrombosis and Haemostasis.

                                View  Johnson's Profile
    
          Contact the lab
    73 Mt Wayte AveFramingham, MA 01702United States
        Phone:
                    508-663-4082
                Fax:
            508-872-2678
  Ming-Huei
    
            Ming-Huei Chen, Ph.D.
        

    Staff Scientist

        ming-huei.chen@nih.gov
            avatar
    
            Amber  Lachapelle
        

    Lab Tech

        amber.lachapelle@nih.gov
            Florian Thibord
    
            Florian Thibord, Ph.D.
        

    Postdoctoral Fellow

        florian.thibord@nih.gov
            Blank Avatar
    
            Ann Walsh
        

    Program Support Assistant

        walshac@mail.nih.gov
            Bongani
    
            Bongani Nkambule, Ph.D.
        

    Postdoctoral Research Fellow

        bongani.nkambule@nih.gov
            Melissa
    
            Melissa Chan, Ph.D.
        

    Postdoctoral Research Fellow

        melissa.liu3@nih.gov
            avatar
    
            Jason Cunha
        

    Postbaccalaureate IRTA Fellow

        jason.cunha@nih.gov
            Robin Pashek
    
            Robin  Pashek
        

    Postbaccalaureate Fellow

        robin.pashek@nih.gov
                    Load more members
  
  Alumni
        

Benjamin A.T. Rodriguez, Ph.D.
        

    IRTA Fellow
                                        2017

      -
            2019
        Benjamin A.T. Rodriguez, Ph.D. is currently a Senior Data Scientist at Valo Health.
      John D. Eicher, Ph.D.
        

    Postdoctoral Fellow
                                        2015

      -
            2017
        John D. Eicher, Ph.D. is currently a Scientific Leader at Glaxo Smith Kline.
      Ci Song, Ph.D.
        

    Postdoctoral Fellow
                                        2015

      -
            2018
        Ci Song, Ph.D. is currently a Manager at Acetelion Pharmaceuticals, J&J.
      Jennifer Huffman, Ph.D.
        

    Postdoctoral Fellow
                                        2016

      -
            2017
        Jennifer Huffman, Ph.D. is currently a Research Scientist at VA Boston Healthcare System.
      Zoe Schneider
        

    Postbaccalaureate Fellow
                                        2018

      -
            2019
        Zoe Schneider  is currently a MPH Student at Rollins School of Public Health.
      Joe Grech
        

    Postbaccalaureate Fellow
                                        2019

      -
            2021
        Joe Grech  is currently a MD student at Loyola University Chicago Stritch School of Medicine. Back To Top Link
  

        

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