Employment Agreement between the Registrant and Kenneth W, Locke, Ph.D.



 EXHIBIT 10.14 
  
 MEDICINOVA 
  
 July 30, 2003 
  
 Kenneth W. Locke, Ph.D. 
 1257 Belleflower Road 
 Carlsbad, CA 92009 
  
 Dear Dr. Locke, 

 
 I am pleased to inform you of your promotion that was approved by the Board of Directors
of MediciNova. 
  
 Your new title effective August 1, 2003 will be: 
  
 Senior Vice President, Development Operations and Drug Discovery 

 
 Your annual base salary will be adjusted to $210,000. 
  
 Congratulations and the Company appreciates your significant contribution. 
  
 With my personal regards, 
  

	
	 
	
	/s/ Takashi Kiyoizumi
	 Takashi Kiyoizumi, M.D., Ph.D.
 President &
CEO


  

	CC:	Rebecca Wong 


	    	HR file 

  
 MediciNova, Inc. 
 4370 La Jolla Village Drive, Suite 400 
 San Diego, California 92122 

	tel	(858) 373-1500 


	fax	(858) 373-7000 


	web	www.medicinova.com 








 EXECUTIVE EMPLOYMENT AGREEMENT 
 (Kenneth W. Locke, Ph.D.) 
  
 This EXECUTIVE EMPLOYMENT AGREEMENT (this “Agreement”) is made as of September 26, 2000 (the “Effective Date”) by and between MEDICINOVA, INC, a Delaware corporation
(“MediciNova”), and Kenneth W. Locke, Ph.D. (“Executive”), with reference to the following facts: 
  
 A.    The Board of Directors of MediciNova (the “Board”) has determined that it would be in the best interests of
MediciNova to enter into this Employment Agreement on the terms herein set forth. 
  
 B.    Executive is willing to serve as an employee of MediciNova upon the terms and conditions herein set forth. In respect of such employment, Executive has also executed that certain Proprietary
Information and Inventions Agreement of even date herewith (the “Proprietary Information and Inventions Agreement”), which is attached hereto as Exhibit A and incorporated herein by reference as though fully set forth herein.

  
 NOW, THEREFORE, in consideration of the foregoing premises and
the mutual covenants herein contained, the parties agree as follows: 
  
 1. Definitions. For purposes of this Agreement, the following terms shall have their respective meanings: 
  
 1.1 “Cause” shall mean (as shall reasonably be determined by the Board of Directors of the MediciNova - the “Board”):
(i) any intentional failure to perform the Executive’s obligations, services or duties under this Agreement or any other agreement or arrangement between the Executive and the MediciNova regarding employment or consulting services to be
rendered by the Executive to the MediciNova, other than an immaterial violation which is remedied upon reasonable notice; (ii) failure to achieve performance levels for the MediciNova consistent with the MediciNova’s goals, as determined by the
Board in good faith and following appropriate inquiry; (iii) any violation of MediciNova policy, other than an immaterial violation which is remedied upon reasonable notice; (iv) any willful neglect of the Executive’s duties to the MediciNova
or gross misconduct; (v) any failure to protect the MediciNova’s trade secrets; or (vi) any commission of any crime or criminal offense involving moral turpitude. 
  
 1.2 “Total and Permanent Disability” shall have the meaning ascribed to such term in Section 22 of the
Internal Revenue Code of 1986, as amended. 
  
 2. Duties.
Subject to the terms and provisions of this Agreement, Executive is employed by MediciNova as an executive employee of MediciNova. Executive’s specific position shall be as the Vice President, Research, of MediciNova; provided,
however, that the Executive may be reassigned by the Board to another executive position with MediciNova (or another position of similar responsibility) at such time as the Board (excluding Executive) reasonably agrees upon another Chief
Executive Officer. Executive covenants to perform Executive’s employment duties in good faith. Executive shall at all times during the 
  

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 performance of this Agreement strictly adhere to and obey any and all rules and regulations now in effect or as
subsequently adopted and/or modified governing the conduct of MediciNova employees and/or executives (the “Employment Policies”). In the event of any conflict between the provisions of this Agreement and any of the Employment
Policies, the provisions of this Agreement shall control. A default under any the Employment Policies, except to the extent necessary or appropriate to comply with the provisions of this Agreement, shall be a default under this Agreement.

  
 3. Exclusive Services. Executive’s entire business
time, attention, energies, skills, learning and best efforts shall be devoted to the business of MediciNova; provided, however, that this Section 3 shall not be construed as preventing Executive from participating in social, civic or
professional associations or engaging in passive outside investment activities which may require a limited portion of time and effort to manage, consistent with any Employment Policies and so long as such activities do not
interfere with the performance of Executive’s duties nor compete, in any way, with the products or services offered by or through MediciNova. 
  
 4. Term of Employment. The term of this Agreement shall continue until such time as the employment of Executive is terminated pursuant to Section 7
below; provided, however, that this Agreement shall automatically terminate upon the death or Total and Permanent Disability of Executive. 
  
 5. Compensation. For all services rendered by Executive to MediciNova, MediciNova shall pay/provide to Executive the following: 
  

	 	•	base compensation in the amount of $ 155,000 per annum (the “Base Compensation”); 

  

	 	•	periodic bonuses determined within the sole discretion of the Board (or any committee of the Board which is appointed to consider matters relating to executive compensation) but
with reference to amounts paid to other executives and/or employees of MediciNova; 

  

	 	•	grants of equity-based compensation within the sole discretion of the Board (or any committee of the Board which is appointed to consider matters relative to equity-based
compensation); 

  

	 	•	such group medical and life insurance and participation in other benefit plans as shall be made available for executives of MediciNova (with amounts and levels of participation
therein determined with reference to other executives and/or employees of MediciNova); and 

  

	 	•	an annual amount of vacation days consistent with amounts available for other executives of MediciNova (but, in any event, no fewer than 10 days)(collectively, the
“Compensation Package”). 

  
 6.
Adjustments. The amount of Base Compensation may be adjusted as of January 1 of each calendar year by an amount upon which the Board and Executive shall mutually and reasonably agree at or about that time. Compensation under the Compensation
Package shall be 
  

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 paid to Executive less required deductions for Social Security, withholding taxes and other authorized deductions and at
times when executives of MediciNova normally receive their compensation. 
  
 7. Termination. The employment of Executive may be terminated at any time by: 
  
 7.1 Mutual agreement of MediciNova and Executive evidenced in writing; 
  
 7.2 Action of the Board without prior notice to Executive if the Board reasonably shall establish that (i) Executive is in
material default in the performance of Executive’s obligations, services or duties hereunder, or has materially breached any provision of this Agreement, or (ii) MediciNova otherwise has Cause to terminate Executive’s employment (although
the right of termination of Executive’s employment under this Section 7.2 shall not be in limitation of any other right or remedy MediciNova may have under this Agreement or otherwise); 
  
 7.3 Upon the death or Total and Permanent Disability of Executive; or

  
 7.4 Upon 180 days’ written notice by either party to the
other indicating the desire of the notifying party, in its sole discretion, to terminate the employment of Executive hereunder. 
  
 8. Compensation Upon Termination. In the event that the employment of Executive is terminated pursuant to Section 7 above, Executive shall be
terminated without compensation other than for accrued salary and other accrued amounts; provided, however, that if such employment is terminated at MediciNova’s option pursuant to Section 7.4 above, then Executive shall be
entitled to such severance payment(s) as shall be provided for (if any) by the Employment Policies in effect at that time; and provided, further, that in lieu of the 180 days’ notice provided by Section 7.4 above, MediciNova may
provide Executive with an amount equal to one-half (1/2) of Executive’s annual Base Compensation which shall be applicable at the time of Executive’s termination of employment with MediciNova. Except as provided in the immediately
preceding sentence (if applicable), Executive is entitled to no other compensation upon termination. 
  
 9. Option to Hire Executive as Consultant. Upon any termination of Executive’s employment under this Agreement, either pursuant to Section 7
above or otherwise, MediciNova shall have the option (in MediciNova’s discretion) to engage Executive as a consultant on a quarterly basis commencing on the effective date of termination of Executive’s employment (the “Termination
Date”) and continuing for a period of up to one (1) year following the Termination Date (or, if longer, the period terminating on the date which is three (3) years after the Effective Date). MediciNova’s
rights under this Section 9 shall lapse if MediciNova has not provided Executive with written notice of MediciNova’s intent to exercise its rights hereunder prior to the later of (i) the Termination Date (e.g., in the event of a voluntary
termination under Section 7.4 above) and (ii) 30 days following notice of such termination (e.g., in the event of an involuntary termination under Section 7.2 above). As a consultant, Executive’s duties shall include devoting attention to those
matters reasonably requested by the Board but which will not interfere (as to time required) with the opportunity to maintain other employment consistent with this Section 9. During any period for which Executive is engaged to perform consulting
services for MediciNova under this Section 9, Executive agrees that Executive shall not: 
  
 9.1 Carry on directly or indirectly, whether or not for compensation (as proprietor, partner, stockholder (except that a less than one percent (1%) ownership in a public corporation shall be permitted), officer,
director, agent, employee, consultant, trustee, affiliate or otherwise), any business which is, or as a result of Executive’s engagement or participation would become, competitive with or adverse to the business of MediciNova as it exists as of
the Termination Date; 
  

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 9.2 Permit Executive’s name to be used by any business competitive in any respect with the business
of MediciNova as it exists as of the Termination Date; 
  
 9.3
Solicit or divert, or attempt to call on, solicit or divert, any customer of MediciNova with whom Executive became acquainted during Executive’s employment or affiliation with MediciNova, either for Executive or for any other person, firm or
corporation; or 
  
 9.4 Induce or attempt to induce any person who
is an employee, agent or consultant of MediciNova to leave the employ of MediciNova. 
  
 Without limiting the other provisions of this Agreement, (i) Executive acknowledges and agrees that it is impossible to measure in money the damages which will befall the MediciNova by reason of Executive’s failure to perform any of
the obligations set forth in this Section 9, (ii) Executive acknowledges that MediciNova shall be entitled to enforce Executive’s obligations under this Section 9 by court injunction (without the posting of a bond or other security), specific
performance or other appropriate equitable relief, (iii) Executive agrees (to the maximum extent permitted by law) to have the provisions of this Section 9 specifically enforced against Executive by any court of equity and (iv) Executive consents to
the entry of injunctive relief against Executive enjoining or restraining any violation or threatened violation of the provisions of this Section 9. 
  
 10. Compensation for Consulting Services. For each quarter (i.e., three-month period) that Executive provides consulting services to MediciNova
pursuant to the option of MediciNova contained in Section 9 above, MediciNova shall pay Executive a sum equal to fifteen percent (15%) of Executive’s annual Base Compensation which shall be applicable at the time of
Executive’s termination of employment with MediciNova (prorated for any period of less than a quarter). The parties expressly agree that when Executive is performing consulting services for MediciNova, Executive is acting as an independent
contractor. Therefore, Executive shall be solely liable for Social Security and income taxes that result from Executive’s compensation as a consultant. In addition, Executive shall not be entitled to any other benefits including, without
limitation, such group medical, life and disability insurance and other benefits as may be provided to employees and/or executives of MediciNova. 
  
 11. Dispute Resolution Procedure. Any dispute arising out of or related to the employment relationship created hereby, including the termination of
that relationship and any allegations of unfair or discriminatory treatment arising under state or federal law or otherwise, to the maximum extent permitted by law, shall be resolved by final and binding arbitration, except where the law
specifically forbids the use of arbitration as a final and binding remedy, or where section (d) below specifically allows a different remedy. The following dispute resolution procedure shall apply: 
  
 11.1 The party claiming to be aggrieved shall furnish to the other party a
written statement of the grievance identifying any witnesses or documents that support the grievance and the relief requested or proposed. 
  

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 11.2 The responding party shall furnish a statement of the relief, if any, that it is willing to provide,
and the witnesses or documents that support its position as to the appropriate action. The parties can mutually agree to waive this step. If the matter is not resolved at this step, the parties shall submit the dispute to non-binding mediation
before a mediator to be jointly selected by the parties. MediciNova will pay the cost of the mediation. 
  
 11.3 If the mediation does not produce a resolution of the dispute, the parties agree that the dispute shall be resolved by final and binding arbitration.
The parties shall attempt to agree to the identity of an arbitrator, and, if they are unable to do so, they will obtain a list of arbitrators from the Federal Mediation and Conciliation Service and select an arbitrator by striking names from that
list. The arbitrator shall have the authority to determine whether the conduct complained of in subsection (a) of this section violates the rights of the complaining party and, if so, to grant any relief authorized by law, subject to the exclusions
of subsection (d) below. The arbitrator shall not have the authority to modify, change or refuse to enforce the terms of any employment agreement between the parties. In addition, the arbitrator shall not have the authority to require MediciNova to
change any lawful policy or benefit plan. The hearing shall be transcribed. MediciNova shall bear the costs of the arbitration if Executive prevails. If MediciNova prevails, Executive will pay half the cost of the arbitration or $500, whichever is
less. Each party shall be responsible for paying its own attorneys fees. 
  
 Arbitration shall be the exclusive final remedy for any dispute between the parties, to the maximum extent permitted by law, including but not limited to disputes involving claims for discrimination or harassment (such as claims under
the Fair Employment and Housing Act, Title VII of the Civil Rights Act of 1964, the Americans with Disabilities Act, or the Age Discrimination in Employment Act), wrongful termination, breach of contract, breach of public policy, physical or mental
harm or distress or any other disputes, and the parties agree that no dispute shall be submitted to arbitration where the party claiming to be aggrieved has not complied with the preliminary steps provided for in subsections (a) and (b) above.

  
 The parties agree that the arbitration award shall be enforceable in any
court having jurisdiction to enforce this Agreement, so long as the arbitrator’s findings of fact are supported by substantial evidence on the whole and the arbitrator has not made errors of law; provided, however, that either
party may bring an action in a court of competent jurisdiction regarding or related to matters involving MediciNova’s confidential, proprietary or trade secret information, or regarding or related to inventions that Executive may claim to have
developed prior to joining MediciNova or after joining MediciNova, pursuant to California Labor Code 2870. The parties further agree that, for violations of Executive’s confidentiality, proprietary information or trade secret obligations which
the parties have elected to submit to arbitration, MediciNova retains the right to seek preliminary injunctive relief in court in order to preserve the status quo or prevent irreparable injury before the matter can be heard in arbitration.

  

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 11.4 MediciNova reserves the right to modify, change or cancel this provision upon 30 days written
notice. However, such cancellation shall not affect matters which have already been submitted to arbitration. 
  
 12. Confidentiality and Inventions. Executive recognizes that MediciNova has and shall continue to have and develop information, knowledge and
rights regarding inventions, confidential information, products, services, future plans, business affairs, processes, trade secrets, technical matters, customer lists, experimental designs and items of intellectual property. Executive hereby
confirms and ratifies the Proprietary Information and Inventions Agreement (which is incorporated herein by reference) and agrees to execute and deliver to MediciNova any other similar agreement(s) presented to Executive by MediciNova from time to
time. 
  
 13. Section Headings. The section headings or
captions in this Agreement are for convenience of reference only and do not form a part hereof, and do not in any way modify, interpret or construe the intent of the parties or affect any of the provisions of this Agreement. 
  
 14. Survival. The obligations and rights imposed upon the parties
hereto by the provisions of this Agreement which relate to acts or events subsequent to the termination of this Agreement shall survive the termination of this Agreement and shall remain fully effective thereafter. 
  
 15. Severability. Should any one or more of the provisions of this
Agreement or of any agreement entered into pursuant to this Agreement be determined to be illegal or unenforceable in any relevant jurisdiction, then such illegal or unenforceable provision shall be modified by the proper court, if possible, but
only to the extent necessary to make such provision enforceable, and such modified provision and all other provisions of this Agreement and of each other agreement entered into pursuant to this Agreement shall be given effect separately from the
provision or portion thereof determined to be illegal or unenforceable and shall not be affected thereby; provided, however, that any such modification shall apply only with respect to the operation of this Agreement in the particular
jurisdiction in which such determination of illegality or unenforceability is made. 
  
 16. Waiver. The failure of either party to enforce any provision of this Agreement shall not be construed as a waiver of any such provision, nor prevent such party thereafter from enforcing such provision or
any other provision of this Agreement. The rights granted both parties herein are cumulative and the election of one shall not constitute a waiver of such party’s right to assert all other legal remedies available under the circumstances.

  
 17. Parties in Interest. Nothing in this Agreement,
whether express or implied, is intended to confer any rights or remedies under or by reason of this Agreement on any persons other than the parties hereto and the successors, assigns and affiliates of MediciNova, nor is anything in this Agreement
intended to relieve or discharge the obligation or liability of any third person to any party to this Agreement, nor shall any provision give any third person any right of subrogation or action over or against any party to this Agreement.

  
 18. Assignment. MediciNova may, in its sole discretion,
assign its rights and obligations, in whole or in part, to any parent, subsidiary or affiliate of MediciNova. This Agreement shall 
  

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 be binding upon the heirs, executors, successors and assigns of Executive. This Agreement contemplates the rendition of
personal services by Executive and Executive may not assign this Agreement or delegate Executive’s responsibilities hereunder. 
  
 19. Entire Agreement. Except for the Proprietary Information and Inventions Agreement and one or more similar agreements between MediciNova and
Executive as may exist from time to time, this Agreement contains the entire agreement of the parties with respect to the subject matter hereof and no representation, inducement, promise or agreement, oral or otherwise, between the parties not
embodied herein shall be of any force or effect. No modification, termination or attempted waiver shall be valid unless in writing and signed by the party against whom or which such modification, termination or waiver is sought to be enforced.

  
 20. Counterparts. This Agreement may be executed in
counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 
  
 IN WITNESS WHEREOF, the parties have executed this Agreement as of the Effective Date. 
  
 MediciNova: 
 MediciNova, Inc., 
 a Delaware corporation 
  

			
	 By:
	 	 /s/ Takashi Kiyoizumi


	 Name:
	 	 Takashi Kiyoizumi, M.D., Ph.D.

	 Title:
	 	 President and CEO


  
 Executive: 

 

			
	 By:
	 	 /s/ Kenneth W. Locke


	 Name:
	 	 Kenneth W. Locke, Ph.D.


  

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 EXHIBIT A 
  

[attached] 
  

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 MEDICINOVA, INC. 
 PROPRIETARY INFORMATION AND INVENTIONS AGREEMENT 
 Kenneth W. Locke, Ph.D. 
  
 MediciNova, Inc. 
 4540 Towne Centre Court 
 San Diego, California 92121 
  
 Ladies and Gentlemen: 
  
 I recognize that MediciNova, Inc., a Delaware corporation (the “Company”), possesses a body of existing technology and intellectual
property rights and is engaged in a continuous program of research, development and production with respect to its business (present and future). 
  
 I understand that: 
  
 A.    As part of my employment by the Company (with the term “employment,” as used herein, to include any consulting
relationship), I am expected to make new contributions and inventions of value to the Company. 
  
 B.    My employment creates a relationship of confidence and trust between me and the Company and that my position places me in a unique position of access to the proprietary technology, trade
secrets and research, development and business information: 
  

	 	(1)	applicable to the business of the Company; or 

  

	 	(2)	applicable to the business of any client, partner or customer of the Company, 

  

which may be made known to me by the Company or by any client, partner or customer of the Company, or learned by me during the period of my employment. 
  
 C.    The Company possesses and will continue to possess
information that has been or will be created, discovered or developed, or has or will otherwise become known to the Company (including, without limitation, information created, discovered, developed or made known by or to me during the period of or
arising out of my employment by the Company), and/or in which property rights have been or will be assigned or otherwise conveyed to the Company, which information has commercial value in the business in which the Company is engaged. All of the
aforementioned information is hereinafter called “Confidential Information.” By way of illustration, but not limitation, Confidential Information includes all data, compilations, blueprints, plans, audio and/or video recordings
and/or devices, information on computer disks, software, tapes, printouts and other printed, typewritten or handwritten documents, specifications, strategies, systems, schemas, methods (including delivery, storage, receipt, transmission,
presentation and manufacture of audio, video, informational or other data or content), business and marketing development plans, customer lists, budgets and unpublished financial statements, licenses and license agreements, research projections,
processes, 







 techniques, designs, sequences, components, programs, technology, ideas, know-how, improvements, inventions (whether or
not patentable or copyrightable), information about operations and maintenance, trade secrets, formulae, models, patent disclosures, information regarding the skills and compensation of other employees of the Company and other information concerning
the actual or anticipated business, research or development of the Company or its actual or potential customers or partners or which is or has been generated or received in confidence by or for the Company by or from any person; and all tangible and
intangible embodiments thereof of any kind whatsoever including, where appropriate and without limitation, all compositions, machinery, apparatus, records, reports, drawings, copyright applications, patent applications, documents, samples,
prototypes, models, products and the like. 
  
 In consideration of
my employment or continued employment, as the case may be, and the compensation received by me from the Company from time to time, I hereby agree as follows: 
  

1.    All Confidential Information shall be the sole property of the Company and its assigns, and the Company and its assigns shall
be the sole owner of all trade secrets, patents, copyrights and other rights in connection therewith. I hereby assign to the Company any rights I may have or acquire in all Confidential Information. At all times during my employment by the Company
and at all times after termination of my employment by me or by the Company for any reason (“Termination”), I will hold in confidence and trust all Confidential Information, and I will not disclose, sell, use, lecture upon or
publish any Confidential Information or anything relating to it without the prior written consent of the Company, except as may be necessary in the ordinary course of performing my duties as an employee of (or consultant to) the Company. 

 
 2.    Without limiting the terms of my employment with
the Company, I agree that during the period of my employment by the Company I will not engage in any employment or activity in any business that is directly or indirectly competitive with the Company or would otherwise conflict with my employment by
the Company. 
  
 3.    All documents, data,
records, apparatus, equipment, sequences, components, programs and other physical property, whether or not pertaining to Confidential Information, furnished to me by the Company or produced by myself or others in connection with my employment shall
be and remain the sole property of the Company and shall be returned promptly to the Company as and when requested by the Company. Even should the Company not so request, I shall return and deliver all such property upon Termination and I will not
take with me any such property, any reproduction of such property or any materials or products derived from such property. I further agree that any property situated on the Company’ s premises and owned by the Company, including disks and other
storage media, filing cabinets or other work areas, is subject to inspection by Company personnel at any time with or without notice. 
  
 4.    I shall promptly disclose any outside activities or interests, including any ownership or participation in the development of
Prior Inventions (as defined in Section 8 below), that conflict or may conflict with the interests of the Company. I understand that I am required to make such disclosures promptly if the activity or interest is related, either directly or
indirectly, to (i) an area of research, development, service, product or product line of the 
  

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 Company, (ii) a manufacturing, development or research methodology or process of the Company or (iii) any activity that I
may be involved with on behalf of the Company. 
  
 5.    I shall promptly disclose to the Company, or any persons designated by it, all improvements, inventions, formulae, processes, programs, techniques, know-how, data and the like, whether or not patentable or
copyrightable, made or conceived or reduced to practice or learned by me, either alone or jointly with others, during the period of my employment with the Company which are related to or useful in the business of the Company, or result from tasks
assigned to me by the Company, or result from use of premises owned, leased or contracted for by the Company (all said improvements, inventions, formulae, processes, techniques, know-how, data and the like shall be collectively hereinafter called
“Inventions”). Such disclosure shall continue for one year after Termination with respect to anything that would be an Invention if made, conceived, reduced to practice or learned prior to Termination. 
  
 6.    I agree to keep and maintain adequate and current
records (in the form of notes, sketches, documentation, drawings and in any other form that may be required by the Company) of all Confidential Information developed by me and all Inventions made by me during the period of my employment at the
Company, which records shall be made available to and remain the sole property of the Company at all times. 
  
 7.    I agree that all Inventions shall be the sole property of the Company and its assigns, and the Company and its assigns shall be
the sole owner of all trade secrets, patents, copyrights and other rights in connection therewith and all Confidential Information with respect thereto. I hereby assign to the Company any and all rights I may have or acquire in all Inventions,
including all rights that may be known as or referred to as “moral rights.” I also acknowledge that all original works of authorship which are made by me (solely or jointly with others) within the scope of my employment and which are
protectable by copyright are “works made for hire” pursuant to the United States Copyright Act (17 U.S.C. Section 101), as amended. I further agree as to all Inventions to assist the Company in every proper way (but at the Company’s
expense) to obtain and from time to time enforce patents and copyrights on Inventions in any and all countries, and to that end I will execute all documents for use in applying for and obtaining such patents and copyrights thereon and enforcing the
same, as the Company may desire, together with any assignments thereof to the Company or persons designated by it. My obligation to assist the Company in obtaining and enforcing patents and copyrights for Inventions in any and all countries shall
continue beyond Termination, but the Company shall compensate me at a reasonable rate after Termination for time actually spent by me at the Company’s request on such assistance. In the event that the Company is unable for any reason whatsoever
to secure my signature to any lawful and necessary document required to apply for or execute any patent or copyright application with respect to Inventions (including renewals, extension, continuations, divisions, continuations in part or
preservation of rights in respect thereof), I hereby irrevocably designate and appoint the Company, and its duly authorized officers and agents, as my agents and attorneys-in-fact to act for and in my behalf and instead of me, to execute and file
any such application and to do all other lawfully permitted acts to further the prosecution and issuance of patents or copyrights thereon with the same legal force and effect as if executed by me. 
  

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 8.    As a matter of record I have identified on Exhibit A hereto a complete
list of all inventions or improvements relevant to the subject matter of my employment by the Company which have been made or conceived or first reduced to practice by me, alone or jointly with others, prior to my employment by the Company
(“Prior Inventions”) which I desire to remove from the operation of this Agreement. If disclosure of any such Prior Invention would cause me to violate any prior confidentiality agreement, I understand that I am not to list such
Prior Invention on Exhibit A hereto but am only to disclose a cursory name for each such Prior Invention, a listing of the party(ies) to whom it belongs and the fact that full disclosure as to such Prior Inventions has not been made for that
reason. I represent that my list of Prior Inventions is complete. If no such list of Prior Inventions is identified, I represent that I have made no such Prior Inventions at the time of the commencement of my employment by the Company.
Notwithstanding the foregoing, and without limiting the other provisions of this Agreement, I agree that (i) any improvements or new inventions to the item(s) so identified on such list (if any) shall be treated as Inventions for purposes of this
Agreement if the provisions of Section 5 above are otherwise applicable and (ii) if, in the course of my employment with the Company, I incorporate a Prior Invention into a Company product, process, application, machine or invention, the Company is
hereby granted and shall have a nonexclusive, royalty-free, irrevocable, perpetual, worldwide license (with rights to sublicense through multiple tiers of sublicensees) to make, have made, modify, use and sell such Prior Invention. Notwithstanding
the foregoing, I agree that I will not incorporate, or permit to be incorporated, Prior Inventions in any Company product, process, application, machine or invention without the Company’s prior written consent. 
  
 9.    I represent that my performance of all the terms of
this Agreement and that my employment by the Company does not and will not breach or constitute an event of default under any agreement (i) obligating me to keep in confidence proprietary information acquired by me in confidence or in trust prior
to, or at any point throughout, my employment by the Company, (ii) obligating me to assign to or protect for the benefit of any third party any proprietary information or any improvement, invention, formulae, process, program, technique, know-how or
data or (iii) that is designed in any way to limit my employment or activity in any business in which I may compete, directly or indirectly, with any other business, or which might by application have such an effect. I have not entered into, and I
agree that I will not enter into, any agreement (either written or oral) in conflict herewith. 
  
 10.    I understand, acknowledge and agree that, as part of the consideration for my employment or continued employment by the Company, I have not brought and will not bring with me to the Company
or use in the performance of my responsibilities at or for the Company any equipment, supplies, facilities, trade secrets or other proprietary information of any former employer which are not generally available to the public, unless I have obtained
(and provide herewith to the Company a copy of) written authorization for their possession and use. 
  
 11.    I also understand that, during the course of my employment by the Company, I am not to breach any obligation of confidentiality
that I have to others, and I agree that I shall fulfill all such obligations during my employment by the Company. A copy of any document reflecting any such obligation, or a description thereof if no document is available, is provided herewith to
the Company. 
  

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 12.    I agree that during the term of my employment with the Company and for a
period of twelve (12) months after Termination, I will not directly or indirectly: (i) induce or attempt to induce any employee or consultant of the Company to leave the employ of the Company or to otherwise end such employee’s or
consultant’s relationships with the Company or (ii) other than on behalf of the Company, induce or attempt to induce any other person to terminate a relationship with the Company. 
  
 13.    After Termination, I hereby consent to the notification of my new employer (if any) of my rights
and obligations under this Agreement. 
  
 14.    I acknowledge that, due to the uniqueness of my relationship with the Company, the Company would not have an adequate remedy at law for money damages in the event that this Agreement is not fully performed in
accordance with its terms. I agree that in addition to any other rights and remedies available to the Company for any breach by me of my obligations hereunder, the Company shall be entitled to enforcement of my obligations hereunder by court
injunction (without the posting of a bond or other security), specific performance or other appropriate equitable relief. 
  
 15.    If any one or more of the provisions of this Agreement shall, for any reason, be held to be invalid, illegal or unenforceable
in any respect, such invalidity, illegality or unenforceability shall not affect the other provisions of this Agreement and this Agreement shall be construed as if such invalid, illegal or unenforceable provision had never been contained herein. If,
moreover, any one or more of the provisions contained in this Agreement shall for any reason be held to be excessively broad as to duration, geographical scope, activity or subject, it shall be construed by limiting and reducing it, so as to be
enforceable to the extent compatible with the applicable law as it shall then appear. 
  
 16.    If applicable, this Agreement does not apply to inventions which qualify fully for protection under Section 2870 of the California Labor Code (which, if applicable, could apply to ideas or
inventions for which no equipment, supplies, facility or trade secret information of the Company were used and which were developed entirely on my own time, and (i) which do not relate at the time of conception or reduction to practice of the
invention (a) to the actual business of the Company, or (b) to the Company’s actual or demonstrably anticipated research or development, or (ii) which do not result from any work performed by me for the Company). Notwithstanding the foregoing,
I shall disclose in confidence to the Company any invention in order to permit the Company to make a determination as to compliance by me with the terms and conditions of this Agreement. 
  
 17.    This Agreement shall be effective as of the first day of my employment by the Company and shall
survive Termination. The term “employment” and the term or duration of my employment, as used herein and for purposes of this Agreement, shall include, without limitation, any consulting relationship between myself and the Company
(including, if applicable, any such relationship which may follow the termination of my status as an employee of the Company or which may precede my status as an employee of the Company). Accordingly, notwithstanding any other provision of this
Agreement to the contrary (and without limitation), a “Termination” shall not be deemed to have occurred if a consulting relationship persists following the termination of my status as an employee of the Company (if applicable).

  

 5 








 18.    The term “Company,” as used herein, shall include any
predecessor entity as well as any subsidiary or affiliate of the Company. 
  
 19.    This Agreement shall be binding upon me, my heirs, executors, assigns and administrators and shall inure to the benefit of the Company, its successors and assigns. 
  
 20.    This Agreement shall be governed by and construed
in accordance with the internal laws of the State of California, without regard to the conflicts of law principles thereof. 
  
 I have read this Agreement carefully and understand its terms. The list of Prior Inventions attached on Exhibit A is complete. 

 

					
	 Dated: September 26, 2000
	 	 Signature:
	 	 /s/ Kenneth W. Locke


	 	 	 Name: Kenneth W. Locke, Ph.D.


  
 Accepted and Agreed to 
  
 this 26th day of September, 2000 
  
 MediciNova, Inc., a Delaware corporation 
  

			
	 By:
	 	 /s/ Takashi Kiyoizumi


	 	 	 Takashi Kiyoizumi, M.D., Ph.D.

	 Its:
	 	 President and CEO









 Exhibit A 
  

(Kenneth W. Locke, Ph.D.) 
  
 Prior Inventions 
  

	(a)	Prior Inventions. Except as set forth in part (b) below, the following is a complete list of all Prior Inventions (as defined in Section 8 of the Proprietary
Information and Inventions Agreement to which this Exhibit is attached) relevant to the present business of the Company: 

  

	    	X    None. 

  

	    	r See below. 

  

	
	 
	
	 
	
	 
	
	 
	
	 
	
	 


  

	    	r Additional sheets attached. 

  

	(b)	Confidential Prior Inventions. Due to a prior confidentiality agreement, I cannot complete the disclosure with respect to the inventions or improvements generally listed
below, the proprietary rights and duty of confidentiality with respect to which I owe to the following party(ies): 

  

															
	 	  	 	 	Invention or Improvement	  	 	 	Party(ies)	  	 	 	Relationship	 	 
								
	1.	  	 	 	 	  	 	 	 	  	 	 	 	 	 
								
	2.	  	 	 	 	  	 	 	 	  	 	 	 	 	 
								
	3.	  	 	 	 	  	 	 	 	  	 	 	 	 	 
								
	4.	  	 	 	 	  	 	 	 	  	 	 	 	 	 
								
	5.	  	 	 	 	  	 	 	 	  	 	 	 	 	 


  

	    	r Additional Sheets Attached.