# Patent

## Title
Synergistic herbicidal composition containing fluroxypyr and quinclorac

## Abstract

An herbicidal synergistic mixture of fluroxypyr and quinclorac provides improved post-emergence weed control in rice, cereal and grain crops, pastures, rangelands, IVM and turf.

## Background
FIELD OF THE INVENTION
This invention concerns a synergistic herbicidal composition containing (a) fluroxypyr and (b) quinclorac for controlling weeds in crops, especially rice, cereal and grain crops, pastures, rangelands, industrial vegetation management (IVM) and turf. This composition provides improved post-emergence herbicidal weed control.
BACKGROUND OF THE INVENTION
The protection of crops from weeds and other vegetation which inhibit crop growth is a constantly recurring problem in agriculture. To help combat this problem, researchers in the field of synthetic chemistry have produced an extensive variety of chemicals and chemical formulations effective in the control of such unwanted growth. Chemical herbicides of many types have been disclosed in the literature and a large number are in commercial use.
In some cases, herbicidal active ingredients have been shown to be more effective in combination than when applied individually and this is referred to as “synergism.” As described in the Herbicide Handbook of the Weed Science Society of America, Eighth Edition, 2002, p. 462 “‘synergism’ [is] an interaction of two or more factors such that the effect when combined is greater than the predicted effect based on the response to each factor applied separately.” The present invention is based on the discovery that fluroxypyr and quinclorac, already known individually for their herbicidal efficacy, display a synergistic effect when applied in combination.
SUMMARY OF THE INVENTION
The present invention concerns a synergistic herbicidal mixture comprising an herbicidally effective amount of (a) fluroxypyr and (b) quinclorac. The composition may also contain an agriculturally acceptable adjuvant and/or carrier.
The present invention also concerns herbicidal compositions for and methods of controlling the growth of undesirable vegetation, particularly in monocot crops including rice, wheat, barley, oats, rye, sorghum, corn, maize, pastures, grasslands, rangelands, fallowland, turf, IVM and aquatics and the use of these synergistic compositions.
The species spectrum of quinclorac is broad and highly complementary with that of fluroxypyr. For example, it has been surprisingly found that a combination of quinclorac and fluroxypyr exhibits a synergistic action in the control of barnyardgrass (Echinochloa crusgalli; ECHCG), Chinese sprangletop (Leptochloa chinensis; LEFCH) and broadleaf signalgrass (Brachiaria platyphylla; BRAPP) at application rates equal to or lower than the rates of the individual compounds.


DETAILED DESCRIPTION OF THE INVENTION
Fluroxypyr is the common name for [(4-amino-3,5-dichloro-6-fluoro-2-pyridinyl) oxy]acetic acid. Its herbicidal activity is described in The Pesticide Manual, Fifteenth Edition, 2009. Fluroxypyr controls a wide range of economically important broadleaf weeds. It can be used as the acid itself or as an agriculturally acceptable salt or ester. Use as an ester is preferred, with the meptyl ester being most preferred.
Quinclorac is the common name for 3,7-dichloro-8-quinolinecarboxylic acid. Its herbicidal activity is described in The Pesticide Manual, Fifteenth Edition, 2009. Quinclorac controls Echinochloa spp., Brachiaria spp., Digitaria spp. and many broadleaf weeds in rice and turf.
The term herbicide is used herein to mean an active ingredient that kills, controls or otherwise adversely modifies the growth of plants. An herbicidally effective or vegetation controlling amount is an amount of active ingredient which causes an adversely modifying effect and includes deviations from natural development, killing, regulation, desiccation, retardation, and the like. The terms plants and vegetation include germinant seeds, emerging seedlings, plants emerging from vegetative propagules, and established vegetation.
Herbicidal activity is exhibited by the compounds of the synergistic mixture when they are applied directly to the plant or to the locus of the plant at any stage of growth or before planting or emergence. The effect observed depends upon the plant species to be controlled, the stage of growth of the plant, the application parameters of dilution and spray drop size, the particle size of solid components, the environmental conditions at the time of use, the specific compound employed, the specific adjuvants and carriers employed, the soil type, and the like, as well as the amount of chemical applied. These and other factors can be adjusted as is known in the art to promote non-selective or selective herbicidal action. Generally, it is preferred to apply the composition of the present invention postemergence to relatively immature undesirable vegetation to achieve the maximum control of weeds.
In the composition of this invention, the weight ratio of fluroxypyr as measured in grams acid equivalent per hectare (g ae/ha) to quinclorac as measured in grams active ingredient per hectare (g ai/ha) at which the herbicidal effect is synergistic lies within the range of between about 1:11 and 22:1.
The rate at which the synergistic composition is applied will depend upon the particular type of weed to be controlled, the degree of control required, and the timing and method of application. Quinclorac is applied at a rate between about 26 g ai/ha and about 560 g ai/ha, and fluroxypyr is applied at a rate between about 50 g ae/ha and about 560 g ae/ha.
The components of the synergistic mixture of the present invention can be applied either separately or as part of a multipart herbicidal system, which can be provided as a premix or a tank mix.
The synergistic mixture of the present invention can be applied in conjunction with one or more other herbicides to control a wider variety of undesirable vegetation. When used in conjunction with other herbicides, the composition can be formulated with the other herbicide or herbicides, tank mixed with the other herbicide or herbicides or applied sequentially with the other herbicide or herbicides. Some of the herbicides that can be employed in conjunction with the synergistic composition of the present invention include: 2,4-D, acetochlor, acifluorfen, aclonifen, AE0172747, alachlor, amidosulfuron, aminotriazole, ammonium thiocyanate, anilifos, atrazine, AVH 301, azimsulfuron, benfuresate, bensulfuron-methyl, bentazone, benthiocarb, benzobicyclon, bifenox, bispyribac-sodium, bromacil, bromoxynil, butachlor, butafenacil, butralin, cafenstrole, carbetamide, carfentrazone-ethyl, chlorflurenol, chlorimuron, chlorpropham, cinosulfuron, clethodim, clomazone, clopyralid, cloransulam-methyl, cyclosulfamuron, cycloxydim, cyhalofop-butyl, dicamba, dichlobenil, dichlorprop-P, diclosulam, diflufenican, diflufenzopyr, dimethenamid, dimethenamid-p, diquat, dithiopyr, diuron, EK2612, EPTC, esprocarb, ET-751, ethoxysulfuron, ethbenzanid, F7967, fenoxaprop, fenoxaprop-ethyl, fenoxaprop-ethyl+isoxadifen-ethyl, fentrazamide, flazasulfuron, florasulam, fluazifop, fluazifop-P-butyl, flucetosulfuron (LGC-42153), flufenacet, flufenpyr-ethyl, flumetsulam, flumiclorac-pentyl, flumioxazin, fluometuron, flupyrsulfuron, fomesafen, foramsulfuron, fumiclorac, glufosinate, glufosinate-ammonium, glyphosate, haloxyfop-methyl, haloxyfop-R, halosulfuron-methyl, imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron, indanofan, indaziflam, iodosulfuron, ioxynil, ipfencarbazone (HOK-201), IR 5790, isoproturon, isoxaben, isoxaflutole, KUH-071, lactofen, linuron, MCPA, MCPA ester & amine, mecoprop-P, mefenacet, mesosulfuron, mesotrione, metamifop, metazosulfuron (NC-620), metolachlor, metosulam, metribuzin, metsulfuron, molinate, MSMA, napropamide, nicosulfuron, norflurazon, OK-9701, orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxazichlomefone, oxyfluorfen, paraquat, pendimethalin, penoxsulam, pentoxazone, pethoxamid, picloram, picolinafen, piperophos, pretilachlor, primisulfuron, profoxydim, propachlor, propanil, propyrisulfuron (TH-547), propyzamide, prosulfocarb, prosulfuron, pyraclonil, pyrazogyl, pyrazosulfuron, pyribenzoxim (LGC-40863), pyriftalid, pyriminobac-methyl, pyrimisulfan (KUH-021), pyroxsulam, pyroxasulfone (KIH-485), quizalofop-ethyl-D, S-3252, sethoxydim, simazine, SL-0401, SL-0402, S-metolachlor, sulcotrione, sulfentrazone, sulfosate, tebuthiuron, tefuryltrione (AVH-301), terbacil, thiazopyr, thiobencarb, triclopyr, trifluralin and tritosulfuron.
The synergistic composition of the present invention can, further, be used in conjunction with glyphosate, glufosinate, dicamba, imidazolinones, sulfonylureas, or 2,4-D on glyphosate-tolerant, glufosinate-tolerant, dicamba-tolerant, imidazolinone-tolerant, sulfonylurea-tolerant and 2,4-D-tolerant crops. It is generally preferred to use the synergistic composition of the present invention in combination with herbicides that are selective for the crop being treated and which complement the spectrum of weeds controlled by these compounds at the application rate employed. It is further generally preferred to apply the synergistic composition of the present invention and other complementary herbicides at the same time, either as a combination formulation or as a tank mix.
The synergistic composition of the present invention can generally be employed in combination with known herbicide safeners, such as benoxacor, benthiocarb, brassinolide, cloquintocet (mexyl), cyometrinil, daimuron, dichlormid, dicyclonon, dimepiperate, disulfoton, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, harpin proteins, isoxadifen-ethyl, mefenpyr-diethyl, MG 191, MON 4660, naphthalic anhydride (NA), oxabetrinil, R29148 and N-phenyl-sulfonylbenzoic acid amides, to enhance their selectivity. Cloquintocet (mexyl) is a particularly preferred safener for the synergistic compositions of the present invention, specifically antagonizing any harmful effect of the synergistic compositions on rice and cereals.
In practice, it is preferable to use the synergistic composition of the present invention in mixtures containing an herbicidally effective amount of the herbicidal components along with at least one agriculturally acceptable adjuvant or carrier. Suitable adjuvants or carriers should not be phytotoxic to valuable crops, particularly at the concentrations employed in applying the compositions for selective weed control in the presence of crops, and should not react chemically with herbicidal components or other composition ingredients. Such mixtures can be designed for application directly to weeds or their locus or can be concentrates or formulations that are normally diluted with additional carriers and adjuvants before application. They can be solids, such as, for example, dusts, granules, water dispersible granules, or wettable powders, or liquids, such as, for example, emulsifiable concentrates, solutions, emulsions or suspensions.
Suitable agricultural adjuvants and carriers that are useful in preparing the herbicidal mixtures of the invention are well known to those skilled in the art. Some of these adjuvants include, but are not limited to, crop oil concentrate (mineral oil (85%)+emulsifiers (15%)); nonylphenol ethoxylate; benzylcocoalkyldimethyl quaternary ammonium salt; blend of petroleum hydrocarbon, alkyl esters, organic acid, and anionic surfactant; C9-C11 alkylpolyglycoside; phosphated alcohol ethoxylate; natural primary alcohol (C12-C16) ethoxylate; di-sec-butylphenol EO-PO block copolymer; polysiloxane-methyl cap; nonylphenol ethoxylate+urea ammonium nitrate; emulsified methylated seed oil; tridecyl alcohol (synthetic) ethoxylate (8EO); tallow amine ethoxylate (15 EO); PEG(400) dioleate-99.
Liquid carriers that can be employed include water, toluene, xylene, petroleum naphtha, crop oil, acetone, methyl ethyl ketone, cyclohexanone, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol monomethyl ether and diethylene glycol monomethyl ether, methyl alcohol, ethyl alcohol, isopropyl alcohol, amyl alcohol, ethylene glycol, propylene glycol, glycerine, N-methyl-2-pyrrolidinone, N,N-dimethyl alkylamides, dimethyl sulfoxide, liquid fertilizers and the like. Water is generally the carrier of choice for the dilution of concentrates.
Suitable solid carriers include talc, pyrophyllite clay, silica, attapulgus clay, kaolin clay, kieselguhr, chalk, diatomaceous earth, lime, calcium carbonate, bentonite clay, Fuller's earth, cottonseed hulls, wheat flour, soybean flour, pumice, wood flour, walnut shell flour, lignin, and the like.
It is usually desirable to incorporate one or more surface-active agents into the compositions of the present invention. Such surface-active agents are advantageously employed in both solid and liquid compositions, especially those designed to be diluted with carrier before application. The surface-active agents can be anionic, cationic or nonionic in character and can be employed as emulsifying agents, wetting agents, suspending agents, or for other purposes. Surfactants conventionally used in the art of formulation and which may also be used in the present formulations are described, inter alia, in “McCutcheon's Detergents and Emulsifiers Annual,” MC Publishing Corp., Ridgewood, N.J., 1998 and in “Encyclopedia of Surfactants,” Vol. I-III, Chemical Publishing Co., N.Y., 1980-81. Typical surface-active agents include salts of alkyl sulfates, such as diethanolammonium lauryl sulfate; alkylarylsulfonate salts, such as calcium dodecylbenzenesulfonate; alkylphenol-alkylene oxide addition products, such as nonylphenol-C18 ethoxylate; alcohol-alkylene oxide addition products, such as tridecyl alcohol-C16 ethoxylate; soaps, such as sodium stearate; alkylnaphthalene-sulfonate salts, such as sodium dibutyl-naphthalenesulfonate; dialkyl esters of sulfosuccinate salts, such as sodium di(2-ethylhexyl) sulfosuccinate; sorbitol esters, such as sorbitol oleate; quaternary amines, such as lauryl trimethylammonium chloride; polyethylene glycol esters of fatty acids, such as polyethylene glycol stearate; block copolymers of ethylene oxide and propylene oxide; salts of mono and dialkyl phosphate esters; vegetable oils such as soybean oil, rapeseed oil, olive oil, castor oil, sunflower seed oil, coconut oil, corn oil, cottonseed oil, linseed oil, palm oil, peanut oil, safflower oil, sesame oil, tung oil and the like; and esters of the above vegetable oils.
Other additives commonly used in agricultural compositions include compatibilizing agents, antifoam agents, sequestering agents, neutralizing agents and buffers, corrosion inhibitors, dyes, odorants, spreading agents, penetration aids, sticking agents, dispersing agents, thickening agents, freezing point depressants, antimicrobial agents, and the like. The compositions may also contain other compatible components, for example, other herbicides, plant growth regulants, fungicides, insecticides, and the like and can be formulated with liquid fertilizers or solid, particulate fertilizer carriers such as ammonium nitrate, urea and the like.
The concentration of the active ingredients in the synergistic composition of the present invention is generally from 0.001 to 98 percent by weight. Concentrations from 0.01 to 90 percent by weight are often employed. In compositions designed to be employed as concentrates, the active ingredients are generally present in a concentration from 1 to 98 weight percent, preferably 5 to 90 weight percent. Such compositions are typically diluted with an inert carrier, such as water, before application, or applied as a dry or liquid formulation directly into flooded rice fields. The diluted compositions usually applied to weeds or the locus of weeds generally contain 0.0001 to 10 weight percent active ingredient and preferably contain 0.001 to 5.0 weight percent.
The present compositions can be applied to weeds or their locus by the use of conventional ground or aerial dusters, sprayers, and granule applicators, by addition to irrigation or paddy water, and by other conventional means known to those skilled in the art.
The following examples illustrate the present invention.
Evaluation of Postemergence Herbicidal Activity of Mixtures in the Greenhouse
Seeds of the desired test plant species were planted in 80% mineral soil/20% grit planting mixture, which typically has a pH of 7.2 and an organic matter content of about 2.9 percent, in plastic pots with a surface area of 128 square centimeters (cm2). The growing medium was steam sterilized. The plants were grown for 7-19 days in a greenhouse with an approximate 14-hour (h) photoperiod which was maintained at about 29° C. during the day and 26° C. during the night. Nutrients and water were added on a regular basis and supplemental lighting was provided with overhead metal halide 1000-Watt lamps as necessary. The plants were treated with postemergence foliar applications when they reached the third to fourth true leaf stage. All treatments were applied using a randomized complete block trial design, with 4 replications per treatment.
Evaluation of Postemergence Herbicidal Activity of Mixtures in the Greenhouse
Treatments consisted of the compounds as listed in Table 1 for each compound applied alone and in combination. Formulated amounts of quinclorac and fluroxypyr-meptyl ester were placed in 60 milliliter (mL) glass vials and dissolved in a volume of 60 mL of a water solution containing Agri-dex crop oil concentrate in a 1% volume per volume (v/v) ratio. Compound requirements are based upon a 12 mL application volume at a rate of 187 liters per hectare (L/ha). Spray solutions of the mixtures were prepared by adding the stock solutions to the appropriate amount of dilution solution to form 12 mL spray solution with active ingredients in single and two way combinations. Formulated compounds were applied to the plant material with an overhead Mandel track sprayer equipped with 8002E nozzles calibrated to deliver 187 L/ha at a spray height of 18 inches (43 centimeters (cm)) above average plant canopy.
The treated plants and control plants were placed in a greenhouse as described above and watered by sub-irrigation to prevent wash-off of the test compounds. Treatments were rated at 21 days after application (DAA) as compared to the untreated control plants. Visual weed control was scored on a scale of 0 to 100 percent where 0 corresponds to no injury and 100 corresponds to complete kill.
Table 1 demonstrates the herbicidal synergistic efficacy of quinclorac+fluroxypyr-meptyl tank mixes on weed control. All treatment results, both for the single product and mixtures, are an average of 4 replicates evaluated at 21 days after application, and the tank mix interactions are significant at the P>0.05 level.
Colby's equation was used to determine the herbicidal effects expected from the mixtures (Colby, S. R. Calculation of the synergistic and antagonistic response of herbicide combinations. Weeds 1967, 15, 20-22.).
The following equation was used to calculate the expected activity of mixtures containing two active ingredients, A and B:

Expected=A+B−(A×B/100)

A=observed efficacy of active ingredient A at the same concentration as used in the mixture.
B=observed efficacy of active ingredient B at the same concentration as used in the mixture.
The compounds tested, application rates employed, plant species tested, and results are given in Table 1. Rates of quinclorac are expressed in grams active ingredient/hectare (g ai/ha) and rates of fluroxypyr are expressed in grams acid equivalent per hectare (g ae/ha) in Table 1.







TABLE 1







Synergistic Activity of Herbicidal Compositions of Quinclorac +


Fluroxypyr-meptyl on grass weeds barnyardgrass (Echinochloa


crus-galli), Chinese sprangletop (Leptochloa chinensis) and


broadleaf signalgrass (Brachiaria platyphylla)


in the greenhouse at 21DAA.








Application Rate











Fluroxypyr-
% Control











Quinclorac
meptyl
ECHCG
BRAPP
LEFCH














(g ai/ha)
(g ae/ha)
Ob
Ex
Ob
Ex
Ob
Ex

















26
0
5
—
—
—
5
—


0
50
0
—
—
—
6
—


26
50
30
5
—
—
20
10


26
0
—
—
—
—
—
—


0
100
—
—
—
—
—
—


26
100
—
—
—
—
—



26
0
5
—
5
—
5
—


0
200
6
—
5
—
41
—


26
200
35
11
30
9
86
44


53
0
6
—
—
—
10
—


0
50
0
—
—
—
6
—


53
50
46
6
—
—
43
15


53
0
6
—
—
—
—
—


0
100
11
—
—
—
—
—


53
100
27
15
—
—
—
—


53
0
6
—
6
—
—
—


0
200
6
—
5
—
—
—


53
200
65
11
48
10
—
—


110
0
31
—
5
—
15
—


0
50
0
—
5
—
6
—


110
50
85
31
25
10
35
20


110
0
31
—
5
—
15
—


0
100
11
—
1
—
50
—


110
100
81
38
51
6
62
57


110
0
31
—
5
—
15
—


0
200
6
—
5
—
42
—


110
200
91
35
31
9
56
50


220
0
65
—
—
—
11
—


0
50
0
—
—
—
50
—


220
50
90
65
—
—
60
55


220
0
65
—
26
—
—



0
100
11
—
1
—
—
—


220
100
86
68
41
27
—
—


220
0
65
—
26
—
—
—


0
200
6
—
5
—
—
—


220
200
75
67
49
30
—
—





BRAPP = Brachiaria platyphylla; broadleaf signalgrass


ECHCG = Echinochloa crus-galli; barnyardgrass


LEFCH = Leptochloa chinensis; Chinese sprangletop


Ob = observed value (% control)


Ex = expected, calculated value using Colby Analysis (% control)


DAA = days after application


g ai/ha = grams active ingredient per hectare


g ae/ha = grams acid equivalent per hectare

## Claims

1. A synergistic herbicidal mixture comprising a herbicidally effective amount of (a) fluroxypyr, or an agriculturally acceptable salt or ester thereof; and (b) quinclorac, or an agriculturally acceptable salt or ester thereof, wherein the weight ratio of fluroxypyr in g ae/ha to quinclorac in g ai/ha is 1:4.4 to 7.7:1.

2. The mixture of claim 1 comprising a herbicidally effective amount of (a) meptyl ester of fluroxypyr; and (b) quinclorac, or an agriculturally acceptable salt or ester thereof.

3. A herbicidal composition comprising a herbicidally effective amount of the herbicidal mixture of claim 1 and an agriculturally acceptable adjuvant and/or carrier.

4. A method of controlling undesirable vegetation which comprises contacting the vegetation or the locus thereof with or applying to the soil or water to prevent the emergence or growth of vegetation a herbicidally effective amount of the herbicidal mixture of claim 1.

5. The method of claim 4 wherein the undesirable vegetation is controlled in rice, cereal and grain crops, pastures, rangelands, industrial vegetation management, or turf.

6. The method of claim 5, wherein quinclorac is applied at a rate of between about 26 g ai/ha and about 560 g ai/ha, and fluroxypyr is applied at a rate of about 50 g ae/ha and between about 560 g ae/ha.

7. The method of claim 6, wherein quinclorac is applied at a rate of between about 26 g ai/ha and 220 g ai/ha, and fluroxypyr is applied at a rate of between about 50 g ae/ha and 200 g ae/ha.

8. The method of claim 4, wherein the undesirable vegetation is barnyardgrass, Chinese sprangletop, or broadleaf signalgrass.

9. The composition of claim 3, further comprising one or more surface-active agents.

10. The composition of claim 3, wherein the concentration of the herbicidal mixture of claim 1 is from 0.001 to 98 percent by weight.

11. The composition of claim 10, wherein the concentration of the herbicidal mixture of claim 1 is from 0.01 to 90 percent by weight.

12. The composition of claim 3, wherein the concentration of the herbicidal mixture of claim 1 is from 1 to 98 percent by weight.

13. The composition of claim 12, wherein the concentration of the herbicidal mixture of claim 1 is from 5 to 90 percent by weight.

14. A method of controlling undesirable vegetation which comprises contacting the vegetation or the locus thereof with or applying to the soil or water to prevent the emergence or growth of vegetation a herbicidally effective amount of (a) fluroxypyr, or an agriculturally acceptable salt or ester thereof; and (b) quinclorac, or an agriculturally acceptable salt or ester thereof, wherein quinclorac is applied at a rate of between about 26 g ai/ha and 220 g ai/ha, and fluroxypyr is applied at a rate of about 50 g ae/ha and 200 g ae/ha.

15. The method of claim 14, which comprises contacting the vegetation or the locus thereof with or applying to the soil or water to prevent the emergence or growth of vegetation a herbicidally effective amount of (a) meptyl ester of fluroxypyr; and (b) quinclorac, or an agriculturally acceptable salt or ester thereof.

16. The method of claim 14, wherein the undesirable vegetation is barnyardgrass, Chinese sprangletop, or broadleaf signalgrass.