Exhibit 4.4


 


AMENDMENT NO. 1 TO THIRD AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT


 


THIS
AMENDMENT NO. 1 (the “Amendment”)
to the THIRD AMENDED AND RESTATED INVESTOR RIGHTS
AGREEMENT (the “IRA”), dated
December 27, 2005, by and among Quark Biotech, Inc., a California corporation (the
“Company”), the Series A Investors, the
Series B Investors, the Series C Investors, the Series D Investors, the Series
E Investors, the Series F Investors, the Series G Investors, the Common Holders
and the Founders (all collectively the “Parties”), is
made effective as of February 12, 2007 by and among the Parties. All
capitalized terms used but not defined herein shall have the meanings given to
them in the IRA.


 


RECITALS


 


WHEREAS, the parties
hereto have previously entered into the IRA; and


 


WHEREAS,  in accordance with Section 8.2 of the IRA, the
parties hereto wish to amend the IRA to reflect the agreements set forth
herein.


 


NOW, THEREFORE, in
consideration of the promises and of the mutual covenants contained herein, the
Parties hereby agree to amend the IRA as follows:


 


AGREEMENT


 


1.             Amendment to
Section 2.5(a).


 


The following language
contained in Section 2.5(a) of the IRA:


 


“(z) the pre-offering
market capitalization of the corporation is at least $200,000,000 (or ¥20,000,000,000 if the
primary listing of shares in on a Japan exchange or over-the-counter market)” 


 


shall be amended to read
as follows: 


 


“(z) the pre-offering
market capitalization of the corporation is at least $125,000,000 (or ¥12,500,000,000 if the primary
listing of shares in on a Japan exchange
or over-the-counter market)” 


 


2.             General 


 


(a)           Full Force and
Effect. Except as expressly modified by this Amendment, all of the terms
and conditions of the IRA shall remain in full force and effect.  


 


(b)           Counterparts.
This Amendment may be executed simultaneously in two or more counterparts, each
of which shall be considered an original, but all of which together shall
constitute one and the same instrument. 


 


(c)           Governing Law.
This Amendment shall be governed by and construed and interpreted in accordance
with the laws of the State of California. 



 

















 


In Witness Whereof, the
Parties hereto have executed this Amendment as of the day and year first set
forth above.


 


 


	
   

  	
  QUARK
  BIOTECH, INC.

  a California corporation

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Daniel Zurr

  	
   

  
	
   

  	
  Daniel Zurr,
  Ph.D.

  
	
   

  	
  Chief Executive
  Officer

  
	
   

  	
   

  
	
   

  	
  Address:

  	
  6501 Dumbarton
  Circle  

  Fremont, CA 94555 

  
	
   

  	
  Fax:

  	
  (510) 402-4020

  
				



 


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  “COMMON
  HOLDERS” AND 

  “FOUNDERS”

  
	
   

  	
   

  
	
   

  	
  /s/ David M.
  Fineman

  
	
   

  	
  /s/ Ellen Gunn
  Fineman

  	
   

  
	
   

  	
  David M. Fineman
  and Ellen Gunn Fineman, 

  Trustees of the Fineman Revocable Trust dated 

  2/12/97

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Ellen Gunn
  Fineman

  	
   

  
	
   

  	
  Ellen Gunn
  Fineman, as Custodian for Chloe Rose 

  Fineman Under the California Uniform 

  Transfers to Minors Act

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Ellen Gunn
  Fineman

  	
   

  
	
   

  	
  Ellen Gunn
  Fineman, as Custodian for Emma Hart 

  Fineman Under the California Uniform 

  Transfers to Minors Act

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  John V. Roos

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Bonnee Rubinfeld

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Bonnee Rubinfeld
  and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Loretta
  Rubinfeld, JTWROS

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ J. Gregory
  Swendsen

  	
   

  
	
   

  	
  J. Gregory
  Swendsen,  

  The J. Gregory Swendsen Revocable Living 

  Trust Dated February 1, 2001

  



 


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  [Common
  Holders and Founders cont’d]

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Susan H.
  Bell,  

  The Susan H. Bell Revocable Trust U/A Dated 

  January 31, 2001

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Daniel Zurr

  	
   

  
	
   

  	
  Daniel Zurr

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Daniel Zurr

  	
   

  
	
   

  	
  Daniel
  Zurr,  

  Goddard and Ephrat Trust Company  

  fbo Mr. Daniel Zurr

  



 


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RESTATED INVESTORS RIGHTS AGREEMENT]


 

















 


	
   

  	
  “SERIES
  A INVESTORS”

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Donald Campbell

  	
   

  
	
   

  	
  Donald T.
  Campbell, IRA FBO Donald T. 

  Campbell/DUSC as Custodian/Rollover 

  Account

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ David L.
  Austin

  	
   

  
	
   

  	
  David L. Austin,
  MLPF&S 

  Custodian FPO David L. Austin  

  RRA Account 813-81530

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Frances M.
  Austin

  	
   

  
	
   

  	
  Frances M.
  Austin, MLPF&S Custodian  

  FPO Frances M. Austin  

  RRA Account 813-81530

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Deborah R.
  Bernstein and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Harvey S. Hecht,
  as Community Property

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Harvey S. Hecht

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Robert
  Brockman,  

  Robert Bruckman, M.D., Inc. Money Purchase 

  Pension Plan

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  First Trust
  Corporation TTEE FBO  

  Harvey Hecht IRA M619043-0001

  



 


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  [Series
  A Investors cont’d]

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Patricia
  Berns

  	
   

  
	
   

  	
  Patricia Berns

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Deborah R.
  Bernstein and Harvey S. Hecht,  

  TTEE Deborah R. Bernstein and Harvey S. 

  Hecht Living Trust

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Robert Bruchnan
  and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Mari Brockman,
  as Community Property

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Robert
  Bruckman,  

  Robert Bruckman, M.D., Inc. Profit Sharing 

  Plan

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Robert Bruckman,
  TTEE  

  Murray A. Bruckman Trust

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Jerome C.
  Dougherty,  

  Trustee for Jerome Dougherty  

  Attorney at Law Money chase Pension and 

  Profit Sharing Plan Trust

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Chrism Pardee
  Erdman

  



 


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  [Series
  A Investors cont’d]

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Lois Pat Lee
  Gintjee,  

  Trustee of the Lois Pat Lee Gintjee  

  Living Trust, dated November 19, 1996

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ David
  Fineman

  	
   

  
	
   

  	
  David Fineman,
  TTEE,  

  The Gunn-Fineman Inc. Profit Sharing and 

  Money Purchase Pension Trust

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Joyce
  Hawkins

  	
   

  
	
   

  	
  Joyce Hawkins,
  TTEE,  

  Hawkins Family Trust dated March 18, 1991

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Jeffrey A.
  Hawkins

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Jonathan D.
  Hawkins

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Roger W.
  Hedin, M.D.

  	
   

  
	
   

  	
  Roger W. Hedin,
  M.D. and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Mary A.
  Hedin

  	
   

  
	
   

  	
  Mary A. Hedin,
  as Community Property

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Bonnie J.
  Lawless

  
				



 


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RESTATED INVESTORS RIGHTS AGREEMENT]


 

















 


	
   

  	
  [Series
  A Investors cont’d]

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Kathleen
  Lewis, M.D.

  	
   

  
	
   

  	
  Kathleen Lewis,
  M.D. and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Julien
  Hoffman

  	
   

  
	
   

  	
  Julien Hoffman,
  as Community Property

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Kathleen
  Lewis, M.D.

  	
   

  
	
   

  	
  San Francisco
  Neonatology Medical Group 

  Profit Sharing Plan fbo Kathleen Lewis, M.D.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  W. Scott Newhall

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Mark I.
  Peterson, TTEE,  

  Mark J. Peterson, Inc. Money Purchase 

  Pension Plan

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Polly Sue
  Ogden

  	
   

  
	
   

  	
  Polly Sue Ogden,
  TTEE,  

  Polly Ogden Associates Keogh Profit Sharing 

  and Money Purchase Pension Plans

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Donald H.
  Oppenheim

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Peter
  Oppenheim

  	
   

  
	
   

  	
  Peter Oppenheim,
  TTEE,  

  Oppenheim Family Trust u/t/a dated June 1974

  



 


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  [Series
  A Investors cont’d]

  
	
   

  	
   

  
	
   

  	
  /s/ Sylvia
  Oppenheim

  	
   

  
	
   

  	
  Sylvia
  Oppenheim, TTEE,  

  Oppenheim Family Trust u/t/a dated June 1974

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Joseph D.
  Sabella, TTEE,  

  Sabella Family Trust dated May 18, 1987

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Iris
  Sabella,  

  Sabena Family Trust dated May 18, 1987

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Jack Sender and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Merideth Sender,
  as Community Property

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Alfred D.
  Oppenheim

  	
   

  
	
   

  	
  Alfred D.
  Oppenheim, TTEE,  

  Oppenheim/Slagle Family Trust u/t/a dated 

  August 12, 1991

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Terri A.
  Slagle

  	
   

  
	
   

  	
  Terri A. Slagle,
  TTEE,  

  Oppenheim/Slagle Family Trust u/t/a dated 

  August 12, 1991

  
				



 


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RESTATED INVESTORS RIGHTS AGREEMENT]


 

















 


	
   

  	
  [Series
  A Investors cont’d]

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Terri A.
  Slagle

  	
   

  
	
   

  	
  Terri A.
  Slagle,  

  San Francisco Neonatology Medical Group 

  Profit Sharing Plan fbo Terri A. Slagle

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Steven
  Goldman

  	
   

  
	
   

  	
  Steven
  Goldman,  

  San Francisco Neonatology Medical Group 

  Profit Sharing Plan fbo Steven Goldman, M.D.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Gerald L.
  Vercesi

  	
   

  
	
   

  	
  Gerald L.
  Vercesi, TTEE,  

  Vercesi Family Trust dated December 15, 1994

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Donna E.
  Vercesi

  	
   

  
	
   

  	
  Donna E.
  Vercesi, TTEE,  

  Vercesi Family Trust dated December 15, 1994

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  James L. Warren
  and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Cassandra H.
  Warren, as Community Property

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Mark
  Wexman,  

  California Central Trust Bank, TTEE, fbo 

  Mark Wexman, M.D.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Mark Wexman,
  M.D. and

  



 


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  [Series
  A Investors cont’d]

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Karen Wexman,
  M.D., as Community Property

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  WS
  INVESTMENT COMPANY 94A

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Illegible

  	
   

  
	
   

  	
  Title:

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Howard B. Zack
  and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Diane C. Zack,
  as Community Property

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ John Ziegler

  	
   

  
	
   

  	
  John Ziegler

  
						



 


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  “SERIES
  B INVESTORS”

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Delaware Charter
  Guarantee & Trust Co., fbo 

  James L. Warren IRA

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Mark Wexman,
  MD:  and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Karen Wexman,
  M.D., as Community Property

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Diane C. Zack
  and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Howard B. Zack,
  as Community Property

  



 


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  “SERIES
  B PURCHASERS”

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  TAKO
  VENTURES, LLC

  a California limited liability company

  



 


	
   

  	
  By:

  	
  Cephalopod
  Corporation, Member

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
  By:  Philip B. Simon, President

  
	
   

  	
   

  	
   

  
	
   

  	
  /s/ Philip B. Simon

  	
   

  
				



 


	
   

  	
   

  
	
   

  	
  /s/ Donald T. Campbell

  	
   

  
	
   

  	
  Donald T.
  Campbell, IRA FBO Donald T. 

  Campbell/DUSC as Custodian/Rollover 

  Account

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Christian Pardee
  Erdman

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Steven
  Goldman

  	
   

  
	
   

  	
  Steven Goldman,
  M.D.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Peter Oppenheim

  	
   

  
	
   

  	
  Peter and Sylvia
  Oppenheim, Trustees 

  Oppenheim Family Trust u/t/a dated June 1974

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Sylvia
  Oppenheim

  	
   

  
	
   

  	
  Peter and Sylvia
  Oppenheim, Trustees 

  Oppenheim Family Trust u/t/a dated June 1974

  



 


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  “SERIES
  C INVESTORS”

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  TAKO
  VENTURES, LLC

  a California limited liability company

  



 


	
   

  	
  By:

  	
  Cephalopod
  Corporation, Member

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
  By:  Philip B. Simon, President

  
	
   

  	
   

  	
   

  



 


	
   

  	
  /s/ Philip B. Simon

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Jeffrey A.
  Hawkins

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Peter Oppenheim
  and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Sylvia
  Oppenheim, TTEES of the Oppenheim 

  Family Trust dated June 12, 1994

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Diane C. Zack
  and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Howard B. Zack,
  as Community Property

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Joseph Rubinfeld

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  John V. Roos

  
				



 


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  [Series
  C Investors cont’d]

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  WS
  INVESTMENT COMPANY 96B

  
	
   

  	
   

  



 


	
   

  	
  By:

  	
  /s/ Illegible

  	
   

  
	
   

  	
  Title:

  	
   

  	
   

  
					



 


	
   

  	
   

  
	
   

  	
  SUPERGEN,
  INC.,

  a California corporation   
  

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Joseph
  Rubinfeld, President

  



 


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  “SERIES
  D INVESTOR”

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  TAKO
  VENTURES, LLC

  a California limited liability company

  
	
   

  	
   

  
	
   

  	
  By:

  	
  Cephalopod
  Corporation, Member

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
  By:  Philip B. Simon, President

  
	
   

  	
   

  	
   

  
	
   

  	
  /s/ Philip B. Simon

  	
   

  
				



 


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  “SERIES
  E INVESTORS”

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  TAKO
  VENTURES, LLC

  a California limited liability company

  



 


	
   

  	
  By:

  	
  Cephalopod
  Corporation, Member

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
  By:  Philip B. Simon, President

  



 


	
   

  	
  /s/ Philip B. Simon

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Robert M.
  Lawless, TTEE,  

  The Trust of Robert M. and Bernadine T. 

  Lawless

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Gerald L.
  Vercesi

  	
   

  
	
   

  	
  Gerald L.
  Vercesi, TTEE,  

  Vercesi Family Trust dated December 15, 1994

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Donna E.
  Vercesi

  	
   

  
	
   

  	
  Donna E.
  Vercesi, TTEE,  

  Vercesi Family Trust dated December 15, 1994

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  James L. Warren
  and

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Cassandra H.
  Warren, as Community Property

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Delaware Charter
  Guarantee & Trust Co.,  

  fbo James L. Warren IRA

  
				



 


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  [Series
  E Investors cont’d]

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  CNA TRUST, TTEE
  FBO Mark Wexman, 

  M.D.

  



 


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  “SERIES
  F INVESTORS”

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  TAISHO
  PHARMACEUTICAL CO., LTD.    

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Akira
  Uehara

  	
   

  
	
   

  	
  Akira Uehara  

  President

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  ASTELLAS
  PHARMA INC.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Hirofaini
  Onosaka

  	
   

  
	
   

  	
  Hirofaini
  Onosaka  

  Senior Corporate Officer  

  Senior Vice President, Corporate Strategy

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  MITSUBISHI
  PHARMA CORPORATION

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Takeshi
  Komine

  	
   

  
	
   

  	
  Name:

  	
  Takeshi Komine

  	
   

  
	
   

  	
  Title:

  	
  President

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  SANKYO
  CO., LTD.  

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  Name:

  	
   

  	
   

  
	
   

  	
  Title:

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  /s/ Doug H.
  Harlan

  	
   

  
	
   

  	
  Doug H. Harlan

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  /s/ Hugh P. Harlan

  	
   

  
	
   

  	
  Hugh P. Harlan

  
					



 


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  “SERIES
  G INVESTORS”

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  TRANS-SCIENCE
  GLOBAL BIO-

  TECHNOLOGY FUND  

  



 


	
   

  	
  By:

  	
  SBI
  Asset Management Co., Ltd. 

  Its Truster

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Kazuyuki
  Matsui

  	
   

  
	
   

  	
  Name:  Kazuyuki Matsui  

  
	
   

  	
  Title:  President

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  TS-US
  NO.1 INVESTMENT 

  PARTNERSHIP  

  
				



 


	
   

  	
  By:

  	
  Trans-Science,
  Inc. 

  Its General Partner

  



 


	
   

  	
   

  
	
   

  	
  /s/ Kiyoshi
  Inoue

  	
   

  
	
   

  	
  Name:  Kiyoshi Inoue

  
	
   

  	
  Title:  CEO & President

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  ASUKA
  DBJ INVESTMENT LPS

  
	
   

  	
   

  
	
   

  	
  By:

  	
  Asuka
  DBJ Partners Co., Ltd. 

  Its General Partner

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Toru Mio

  	
   

  
	
   

  	
  Name:  Toru Mio

  
	
   

  	
  Title:  Representative Director

  
				



 


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  MUFG
  VENTURE CAPITAL I, LIMITED PARTNERSHIP 
  

  
	
   

  	
   

  
	
   

  	
  By:

  	
  The
  Mitsubishi UFJ Capital Company 

  Limited, its General Partner

  



 


	
   

  	
   

  
	
   

  	
  /s/ Kazuhiko
  Tokita

  	
   

  
	
   

  	
  Name:  Kazuhiko Tokita  

  
	
   

  	
  Title:  President

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  ORIX
  FUND NO. 9

  
	
   

  	
   

  
	
   

  	
  By:

  	
  Orix
  Capital Corporation

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Akira Hirose

  	
   

  
	
   

  	
  Name:  Akira Hirose  

  
	
   

  	
  Title:  President

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  CONCORDIA
  INVESTMENT, L.P.    

  
	
   

  	
   

  
				



 


	
   

  	
  /s/ Hirotoshi
  Komoda

  	
   

  
	
   

  	
  Name:  Hirotoshi Komoda  

  
	
   

  	
  Title:

  	
  CEO&
  President, Birdhill,  

  Its General Partner

  
				



 


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  TRANS-SCIENCE
  NO.3 INVESTMENT LIMITED PARTNERSHIP  

  
	
   

  	
   

  
	
   

  	
  By:

  	
  Trans-Science,
  Inc. 

  Its General Partner

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Kiyoshi
  Inoue

  	
   

  
	
   

  	
  Name:  Kiyoshi Inoue  

  
	
   

  	
  Title:  CEO & President

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  TOKIO
  MARINE & NICHIDO FIRE 

  INSURANCE CO., LTD.

  
	
   

  	
   

  
	
   

  	
  New
  Financial Markets Dep

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Takashi
  Yoshikawa

  	
   

  
	
   

  	
  Name:  Takashi Yoshikawa  

  
	
   

  	
  Title:  General Manager

  
	
   

  	
   

  
	
   

  	
  ZENSHIN
  CAPITAL FUND 1F 

  PARTNERSHIP  

  
				



 


	
   

  	
  By:

  	
  Zenshin
  Capital Partners, LLC 

  Its General Partner

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/ Takeshi Mori

  	
   

  
	
   

  	
  Name:  Takeshi Mori  

  
	
   

  	
  Title:  Managing Member

  
				



 


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