UNITED STATES
SECURITIES AND EXCHANGE COMMISSIONWashington, D.C. 20549



FORM 10-K/A
(Amendment No. 1)



|(Mark One) |                                                                                     
|---------- | ------------------------------------------------------------------------------------
|           |                                                                                     
|x          | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|           |                                                                                     
|           | For the fiscal year ended December 31, 2014                                         
|           |                                                                                     

or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------
|  |                                                                                         
|  | For the transition period from _______________ to _______________                       
|  |                                                                                         

Commission file number 001-32518







NUO THERAPEUTICS, INC.

(Exact name of registrant as specified in
its charter)



|Delaware                                                       | 23-3011702                          
|-------------------------------------------------------------- | ------------------------------------
|(State or other jurisdiction of
incorporation or organization) | (I.R.S. Employer
Identification No.)
|                                                               |                                     

207A Perry Parkway, Suite 1
Gaithersburg, MD 20877

(Address of principal executive offices)
(Zip Code)



(240) 499-2680

(Registrant’s telephone number, including
area code)



Securities registered under Section 12(b)
of the Exchange Act: None
Securities registered under Section 12(g) of the Exchange Act:



Common Stock, $0.0001 par value

(Title of class)



Indicate by check mark if the registrant is a well-known seasoned
issuer, as defined in Rule 405 of the Securities Act. Yes  ̈
No x



Indicate by check mark if the registrant is not required to
file reports pursuant to Section 13 or Section 15(d) of the Act. Yes  ̈ No x



Indicate by check mark whether the registrant (1) has filed
all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months
(or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements
for the past 90 days.
Yes x No  ̈



Indicate by check mark whether the registrant has submitted
electronically and posted on its corporate web site, if any, every Interactive Data File required to be submitted and posted pursuant
to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit
and post such files).
Yes x No  ̈



Indicate by check mark if disclosure of delinquent filers pursuant
to Item 405 of Regulation S-K (§229.405 of this chapter) is not contained herein, and will not be contained, to the best of
registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K
or any amendment to this Form 10-K. x



Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See definition of “accelerated filer,
large accelerated filer”, and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):



|Large accelerated filer  ̈ | Accelerated filer  ̈        
|------------------------- | ---------------------------
|Non-accelerated filer  ̈   | Smaller reporting company x
|                          |                            

Indicate by check mark whether the registrant is a shell company
(as defined in Rule 12b-2 of the Exchange Act).
Yes  ̈ No x



The aggregate market value of the voting and non-voting stock
held by non-affiliates of the registrant as of June 30, 2014, the last business day of the registrant’s most recently completed
second fiscal quarter, was approximately $39 million based on the closing price reported for such date on the OTC Markets Group
OTCQX marketplace.



As of April 17, 2015 the number of shares outstanding of the
registrant’s Common Stock, $0.0001 par value, was 125,680,100











NUO THERAPEUTICS, INC.



TABLE OF CONTENTS



|PART
    III                                                                                                | 5 
|----------------------------------------------------------------------------------------------------------- | --
|                                                                                                            |   
|ITEM
    10. Directors, Executive Officers and Corporate Governance                                         | 5 
|                                                                                                            |   
|ITEM
    11. Executive Compensation                                                                         | 13
|                                                                                                            |   
|ITEM
    12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters | 17
|                                                                                                            |   
|ITEM
    13. Certain Relationships and Related Transactions, and Director Independence                      | 20
|                                                                                                            |   
|ITEM
    14. Principal Accounting Fees and Services                                                         | 22
|                                                                                                            |   
|PART
    IV                                                                                                 | 23
|                                                                                                            |   
|ITEM
    15. Exhibits and Financial Statement Schedules.                                                    | 23











EXPLANATORY NOTE



This Amendment No. 1 on Form 10-K/A (this “Form 10-K/A”)
to the Annual Report on Form 10-K of Nuo Therapeutics, Inc. (the “Company” or “Nuo Therapeutics”) for the
year ended December 31, 2014, filed with the U.S. Securities and Exchange Commission on March 31, 2015 (the “Original 10-K”),
is being filed for the purposes of including the information required by Part III (Items 10-14) of Form 10-K.



As a result, Part III (Items 10-14) of the Original 10-K is
hereby amended and restated in its entirety. As required by Rule 12b-15, in connection with this Form 10-K/A, the Company’s
principal executive officer and principal financial officer are each providing Rule 13a-14(a) certifications dated April 30, 2015.



Except as described above, this Form
10-K/A does not modify or update disclosure in, or exhibits to, the Original 10-K, and such disclosure in, or exhibits to, the
Original 10-K remain unchanged and speak as of the date of the original filing. In particular, this Form 10-K/A does not change
any previously reported financial results, nor does it reflect events that occurred after the date of the Original 10-K.



4







PART III



ITEM 10. Directors, Executive Officers and Corporate Governance



The following table sets forth the names and ages of all Nuo
Therapeutics directors and executive officers. Officers are appointed by, and serve at the pleasure of, the Board of Directors.



|Name                 |  | Age |  | Position                            
|-------------------- |  | --- |  | ------------------------------------
|                     |  |     |  |                                     
|David E. Jorden      |  | 52  |  | Executive Chairman of the Board     
|                     |  |     |  |                                     
|Martin P. Rosendale  |  | 58  |  | Chief Executive Officer and Director
|                     |  |     |  |                                     
|Joseph Del Guercio   |  | 43  |  | Independent Director                
|                     |  |     |  |                                     
|Stephen N. Keith     |  | 62  |  | Independent Director                
|                     |  |     |  |                                     
|Mark T. McLoughlin   |  | 59  |  | Independent Director                
|                     |  |     |  |                                     
|C. Eric Winzer       |  | 58  |  | Independent Director                
|                     |  |     |  |                                     
|Lyle A. Hohnke       |  | 72  |  | Independent Director                
|                     |  |     |  |                                     
|Steven A. Shallcross |  | 53  |  | Chief Financial Officer             
|                     |  |     |  |                                     
|Peter A. Clausen     |  | 49  |  | Chief Scientific Officer            
|                     |  |     |  |                                     
|Dean Tozer           |  | 48  |  | Chief Commercial Officer            
|                     |  |     |  |                                     





Biographical Information of Directors and Executive Officers



Biographical information with respect to the Company’s
current executive officers and directors is provided below.



David E. Jorden has served as
Executive Chairman since February 2012 and was previously an executive board member since October 2008. Since June 2013, he
has served as part-time Chief Executive Officer of Nanospectra Biosciences, Inc., a medical device company developing
therapies for the photothermal ablation of solid tumors utilizing gold nanoparticles. From August 2012 thru March 2013, he
held the position of Acting Chief Financial Officer for Opexa Therapeutics, Inc. (Nasdaq: OPXA) where he also served on the
board from August 2008 through November 2013. From 2003 to 2008, he was with Morgan Stanley’s Private Wealth Management
group where he was responsible for equity portfolio management for high net worth individuals. Prior to Morgan Stanley, Mr.
Jorden served as CFO for Genometrix, Inc., a private genomics/life sciences company focused on high-throughput microarray
applications. Mr. Jorden was previously a principal with Fayez Sarofim & Co. Mr. Jorden has a MBA from
Northwestern University’s Kellogg School and a B.B.A. from University of Texas at Austin. He holds both Certified
Financial Analyst and Certified Public Accountant designations. He is also on the board of Nanospectra Biosciences and PLx
Pharma, LLC, a specialty pharmaceutical company developing GI safer NSAIDs (nonsteroidal anti-inflammatory drugs). Mr.
Jorden's knowledge and experience as an executive officer with life sciences companies and with the financial industry
qualify him to be a member of the Board of Directors. Mr. Jorden has agreed to accept the position of Acting Chief Financial
Officer of the Company, a role which he will officially assume effective as of May 25, 2015 and in connection therewith will
give up his role as Executive Chairman but will continue to serve as a member of the Board of Directors.



Martin P. Rosendale has served as our Chief Executive
Officer and Director since July 1, 2008. Prior to that, in March 2008, he was appointed as Executive Vice-President and Chief Operating
Officer of the Company. From January 2005 to March 2008, Mr. Rosendale held the position of Chief Executive Officer of Core
Dynamics, Inc., a Rockville, MD biotechnology startup company using cryopreservation technology developed in Israel. From March
2001 to December 2004, Mr. Rosendale held the position of Senior Vice President and General Manager of ZLB Bioplasma, Inc.,
a Glendale, CA biologics company, as well as other positions at various biotechnology companies. Mr. Rosendale holds a Bachelor
of Science degree in Microbiology from California State University in Long Beach, CA (1982). Mr. Rosendale's service to the Company
and long experience in our industry qualifies him to be a member of the Board of Directors.





5









Joseph Del Guercio has served as served as Director
since February 8, 2012. He has been Managing Director at CNF Investments (CNF)/Clark Enterprises, an Aldagen investor, since November
2004. Prior to joining CNF, he was a director with LPL Financial Services, a Boston and San Diego based independent broker dealer,
with responsibility for strategic planning, new product development, and acquisitions. Mr. Del Guercio started his career as an
investment banker with Goldman Sachs and Robertson Stephens, where he focused on mergers and acquisitions, private and public
equity financings, and restructurings. Mr. Del Guercio serves on the boards of directors of Terrago Technologies Inc., an Atlanta-based
technology company, American Honors College, a Washington, D.C. based education business, AnyPresence Inc., a Virginia based technology
company, PlaceCast Inc., a California based technology company, Flyby Media, Inc., a New York-based technology company, Verax
Biomedical, Inc., a privately held company based in Worcester, Massachusetts, Overture Technologies, Inc., a Bethesda, MD-based
software company, and Orchestro, Inc., a Virginia based technology company. Mr. Del Guercio is also an advisory board member on
a number of CNF’s fund investments. Mr. Del Guercio has an M.B.A. degree from Harvard Business School and a B.S. degree
from Boston College.  Mr. Del Guercio's experience in the financial industry qualifies him to be a member of the Board of
Directors.  Effective May 1, 2015, Mr. Del Guercio will become Acting Chairman of the Board.





Stephen N. Keith, MD, MSPHhas served as a Director
since September 19, 2008. Dr. Keith served as the Chief Executive Officer of the American College of Clinical Pharmacology, a premier
professional society for the discipline of clinical pharmacology, from 2009 until early 2012. From 2006 until 2009, Dr. Keith served
as President and Chief Operating Officer of Panacea Pharmaceuticals, Inc. From 2003 until 2006, Dr. Keith was a Managing Director
of Glocap Advisors, an investment bank based in New York, and a Senior Consultant with the Biologics Consulting Group. During 2002
– 2003, Dr. Keith was a General Partner with Emerging Technology Partners, an early-stage life sciences venture capital firm
in Maryland. Just prior to joining Emerging Technology Partners, he held the position of President and Chief Operating Officer
at Antex Biologics Inc. From 1995 to 2000, Dr. Keith served as Vice President, Marketing and Sales, at North American Vaccine,
Inc. From 1990 to 1995, Dr. Keith held various positions at Merck & Co., Inc., including Senior Director, Health Care Delivery
Policy in Corporate Public Affairs, Senior Customer Manager in the U.S. Human Health Division, and Senior Director, Health Strategies,
in the Merck-Medco Managed Care Division. Dr. Keith completed his undergraduate work at Amherst College, Amherst, Massachusetts,
in 1973, and he received the M.D. degree from the University of Illinois in 1977. Dr. Keith completed a three-year residency in
Pediatrics at the University of California, Los Angeles, Center for the Health Sciences in 1980. From 1980 to 1982, he was a Robert
Wood Johnson Foundation Clinical Scholar at UCLA, during which time he received a Masters in Science in Public Health from UCLA.
From 1982 to 1987, Dr. Keith served on the faculty of the Charles Drew Medical School and the UCLA School of Medicine in the Department
of Pediatrics. From 1987 to 1990, Dr. Keith served as a Health Policy Advisor to the U.S. Senate Committee on Labor and Human Resources,
under Senator Edward M. Kennedy. He is currently a Site Director for WellStreet Urgent Care in Atlanta, Georgia, a position he
assumed in 2012, serves as a member of the Boards of Directors of The David Winston A. Winston Health Policy Fellowship, National
Medical Fellowships, and Community Health Charities, and is a Fellow of the Academy of Pediatrics and a Diplomate of the American
Board of Pediatrics. Dr. Keith's medical and scientific expertise qualifies him to be a member of the Board of Directors.



Mark T. McLoughlin has served as a Director since
June 7, 2004. Mr. McLoughlin currently serves as Senior Vice President & President U.S. Laboratory Solutions for VWR International,
LLC, a position he has held since July 2012. As Senior Vice President & President of U.S. Laboratory Supply, Mr. McLoughlin
leads all sales, marketing, services and operations for the U.S. Mr. McLoughlin joined VWR in September 2008. Prior to his
current role, Mr. McLoughlin was Senior Vice President of Category Management as well as Senior Vice President of Emerging
Businesses. Mr. McLoughlin brings over 35 years of commercial and strategic management experience, which the Company believes
qualifies Mr. McLoughlin to be a member of the Board of Directors. He has been responsible for leading a combination of VWR’s
distribution, manufacturing and regional businesses throughout North America. Before joining VWR, Mr. McLoughlin held the
position of Senior Vice President, Chief Marketing Officer for Cardinal Health, Inc. based in Geneva, Switzerland, where he designed
and implemented an International Strategic Marketing Organization to support all of the Cardinal Health business outside of the
U.S. and Canada. Prior to this position, from 2002 – 2007, Mr. McLoughlin was Senior Vice President, General
Manager of Cardinal Health’s Scientific Products Clinical Laboratory business located in McGaw Park, IL. Mr. McLoughlin
serves on the Board of Advisors for the Center for Services Leadership, W.P. Carey School of Business at Arizona State University.
He graduated from the University of Arizona with a bachelor of arts, majoring in psychology.





6







C. Eric Winzer has served as Director since January
30, 2009. Mr. Winzer currently serves as Chief Financial Officer of OpGen, Inc., a privately held, whole-genome analysis company
headquartered in Gaithersburg, MD. Prior to joining OpGen, Mr. Winzer was Executive Vice President and Chief Financial Officer
of Avalon Pharmaceuticals, Inc. (Nasdaq: AVRX) from July 2007 to June 2009. Mr. Winzer was with Life Technologies Corporation
(Nasdaq: LIFE), formerly Invitrogen Corporation, a provider of life science technologies for disease research and drug discovery,
from 2000 to 2006, where he served as Senior VP and Chief Financial Officer, Executive Sponsor for Life’s ERP implementation
and VP, Finance. From 1986 to 2000, Mr. Winzer held positions of increasing responsibilities at Life Technologies, Inc., including
Chief Financial Officer, Secretary and Treasurer. From 1980 until 1986, he held various financial positions at Genex Corporation.
Mr. Winzer received his B.A. in Economics and Business Administration from McDaniel College and an M.B.A. from Mount Saint
Mary’s University. Mr. Winzer's experience in the industry qualifies him to be a member of the Board of Directors.



Dr. Lyle Hohnke has served as served as Director
since February 8, 2012. He previously served as a member of Aldagen’s Board from August 2008 to February 2012 and Aldagen’s
President and Chief Executive Officer from October 2010 to February 2012. He was previously a partner of Tullis Dickerson, a healthcare-focused
venture capital fund and an investor in Aldagen. Dr. Hohnke holds Ph.D. and M.A. degrees from the University of Oregon and was
a postdoctoral fellow at the UCLA School of Medicine. He also holds an M.B.A. degree from the Hartford Graduate Institute at Rensselaer
Polytechnic Institute and a B.A. degree from Western Michigan University. Dr. Hohnke’s qualifications to serve on the Board
of Directors include his experience in working with entrepreneurial companies in the healthcare field and his business and finance
background.



Steven A. Shallcross, CPA has served as our Chief
Financial Officer since May 10, 2013. From July 2012 to his joining the Company, Mr. Shallcross held the offices of Executive
VP, Chief Financial Officer and Treasurer of Empire Petroleum Partners, LLC, a motor fuel distribution company. From July 2011
to March 2012, Mr. Shallcross was Acting Chief Financial Officer for Sensors for Medicine and Science, Inc., a privately held
medical device company in Germantown, MD. From January 2009 to March 2011, he was Executive Vice President and Chief Financial
Officer at Innocoll Holdings, Inc., a private held biopharmaceutical company in Ashburn, VA. From November 2005 to January 2009,
he was Senior Vice President, Chief Financial Officer and Treasurer of Vanda Pharmaceuticals Inc., a Nasdaq (VNDA) listed biopharmaceutical
company in Rockville, MD. Mr. Shallcross holds an MBA degree from the University of Chicago, Booth School of Business (1994)
and a BS in Accounting degree from University of Illinois (1983). Mr. Shallcross has tendered his resignation to the Board effective
as of May 24, 2015.



Peter A. Clausenwas appointed as the Chief Science
Officer on March 30, 2014. He joined Cytomedix in September 2008 and has more than 20 years of experience in the biotechnology
industry. Prior to joining Cytomedix, Dr. Clausen was a founding member and Vice President of Research and Development at Marligen
Bioscience, where he developed and commercialized innovative genomic and protein analysis products for the life sciences market.
Dr. Clausen was the Manager of New Purification Technologies at Life Technologies and the Invitrogen Corporation. He also
has significant experience within the commercial biotechnology industry developing peptide and small molecule therapeutics for
application in the areas of inflammatory mediated disease and stem cell transplantation. He completed his post-doctoral training
at the Laboratory of Molecular Oncology at the National Cancer Institute where his research efforts focused in the areas of oncology,
hematopoiesis, and gene therapy. Dr. Clausen earned Ph.D. in Biochemistry from Rush University in Chicago and a Bachelor of Science
degree in Biochemistry from Beloit College.



Dean Tozerwas appointed as the Company’s
Chief Commercial Officer on March 30, 2014. From 2006 to 2011, he was Senior Vice President at Advanced BioHealing Inc. where he
was responsible for the acquisition and reintroduction of Dermagraft® into the U.S. market. Subsequently, Mr. Tozer was Vice
President of Corporate Development at Shire Regenerative Medicine following the acquisition of Advanced BioHealing, where he led
the business development efforts for that division including the 2012 acquisition of Pervasis Therapeutics, Inc. Mr. Tozer holds
a Bachelor of Commerce degree from St. Mary’s University in Halifax, Canada and is a Certified Management Accountant.





7







There are no family relationships between any of the Company’s
executive officers or directors and there are no arrangements or understandings between a director and any other person pursuant
to which such person was elected as director.



Board of Directors



The Board oversees the business affairs of Nuo Therapeutics
and monitors the performance of management. Presently, there are seven Board members. At each annual meeting, shareholders elect
directors for a full term or the remainder thereof, as the case may be, to succeed those whose terms have expired. Each director
holds office for the term for which he or she is elected or until his or her successor is duly elected.



There were no material changes to the procedures by which shareholders
may recommend nominees to the Board since the Company’s last disclosure of such policies.



No director or officer of the Company has, during the last 10
years, been subject to or involved in any legal proceedings described under Item 401(f) of Regulation S-K, been convicted of any
criminal proceeding (excluding traffic violations or similar misdemeanors), or been a party to a civil proceeding of a judicial
or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or
final order enjoining future violations of, or prohibiting or mandating activities subject to, U.S. federal or state securities
laws or finding any violations with respect to such laws.



Director and Board Nominee Independence



The Company’s current directors include
Stephen Keith, Mark McLoughlin, David Jorden, Joseph Del Guercio, Lyle Hohnke, Martin Rosendale and Eric Winzer. The
Company’s securities are being quoted on the OTC Markets Group OTCQX marketplace. The Board elects to apply the NASDAQ Stock
Market corporate governance requirements and standards in its determination of the independence status of each Board and
Board committee member. All of the Company’s current directors meet such independence requirements with the exception
of Messrs. Rosendale and Jorden, neither of which serves on the Audit Committee of the Board. The members of the Audit
Committee are also “independent” for purposes of Section 10A-3 of the Exchange Act and NASDAQ Stock Marketplace
rules. The Board based its independence determinations primarily on a review of the responses of the directors and executive
officers to questions regarding employment and transaction history, affiliations and family and other relationships and on
discussions with the directors. None of our directors engages in any transaction, relationship, or arrangement contemplated
under section 404(a) of Regulation S-K.



Membership, Meetings and Attendance



Our Board has three committees: Audit Committee, Compensation
Committee, and the Nominating and Governance Committee. In 2014, each of our directors attended at least 75% of the aggregate of
the total number of meetings of the Board and the total number of meetings held by all committees of the Board on which he served.
The Board discussed various business matters informally on numerous occasions throughout the year 2014. In addition, the Board
met twenty three times in person or telephonically and the Board Committees held a total of 9 meetings.



The membership and responsibilities of these current committees
are summarized below. Additional information regarding the responsibilities of each committee is found in, and is governed by,
our Bylaws, as amended, each committee’s Charter, where applicable, specific directions of the Board, and certain mandated
regulatory requirements. The Charters of the Audit, Compensation, and Nominating and Governance Committees, as well as the Code
of Conduct and Ethics are available at the Company’s website at http://www.nuot.com.

Director Attendance at Annual Meeting



The Company has no specific policy requiring Director attendance
at its Annual Meeting. Our Annual Meeting held on November 12, 2014 was attended by three of our Directors, including our Chairman
and Chief Executive Officer.





8







Audit Committee



The Board formed an Audit Committee in December 2004. Mr. Winzer
currently serves as chairman of the Audit Committee. The Board has determined that Mr. Winzer is an audit committee financial
expert as defined by Item 407(d) of Regulation S-K under the Securities Act and is “independent” as the term is defined
under the federal securities laws. Other members of the Audit Committee are Mr. McLoughlin and Dr. Keith. Following its transition
from the NYSE Amex, the Company is no longer subject to the requirements of the NYSE Amex Company Guide
and, particularly, the “independence” standards set forth in the Company Guide. However, the Company applies NASDAQ
Stock Market “independence” standard in its assessment of director and committee member independence. The Board has
determined that each member of the Audit Committee is “independent” as required by the NASDAQ Stock Market rules and
regulations and under the federal securities laws. The Audit Committee has a written charter adopted by the Board, which is available
on the Company’s website at www.nuot.com and at no charge by contacting the Company at its headquarters as listed
on the cover page of this report. Information appearing on the Company’s web site is not part of this Annual Report.



The purpose of the Audit Committee is to assist the Board in
its general oversight of Nuo Therapeutics’s financial reporting, internal controls and audit functions. As described in the
Audit Committee Charter, the Audit Committee’s primary responsibilities are to:



| | · | Review whether or not management has maintained the reliability and integrity of the accounting
policies and financial reporting and disclosure practices of the Company;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | Review whether or not management has established and maintained processes to ensure that an adequate
system of internal controls is functioning within the Company;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | Review whether or not management has established and maintained processes to ensure compliance
by the Company with legal and regulatory requirements that may impact its financial reporting and disclosure obligations;
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | Oversee the selection and retention of the Company’s independent public accountants, their
qualifications and independence;
| | - | ---------------------------------------------------------------------------------------------------------------------------



| | · | Prepare a report of the Audit Committee for inclusion in the proxy statement for the Company’s
annual meeting of shareholders;
| | - | ------------------------------------------------------------------------------------------------------------------------------



| | · | Review the scope and cost of the audit, the performance and procedures of the auditors, the final
report of the independent auditors; and
| | - | -----------------------------------------------------------------------------------------------------------------------------------------



| | · | Perform all other duties as the Board may from time to time designate.
| | - | ----------------------------------------------------------------------



Compensation Committee



The Compensation Committee was established in December
2004. Mr. Hohnke is the Chairman of this Committee, with  Mr. McLoughlin being the other member of the Committee.  Until December 31, 2014, Richard Kent served as the third member of the Committee. The Board intends
to fill the vacancy created by his departure at its next meeting. The duties
of the Committee include, among others, establishing any director compensation plan or any executive compensation plan or
other employee benefit plan which requires shareholder approval; establishing
significant long-term director or executive compensation and director or executive benefits plans which do not require
stockholder approval; determination of any other matter, such as severance agreements, change in control agreements, or
special or supplemental executive benefits, within the Committee’s authority; determining the overall compensation
policy and executive salary plan; and determining the annual base salary, annual bonus, and annual and long-term equity-based
or other incentives of each corporate officer, including the CEO.





9







Although a number of aspects of the CEO’s compensation
may be fixed by the terms of his employment contract, the Compensation Committee retains discretion to determine other aspects
of the CEO’s compensation. The CEO reviews the performance of the executive officers of the Company (other than the CEO)
and, based on that review, the CEO makes recommendations to the Compensation Committee about the compensation of executive officers
(other than the CEO). The CEO does not participate in any deliberations or approvals by the compensation committee or the Board
with respect to his own compensation. The Compensation Committee makes recommendations to the Board about all compensation decisions
involving the CEO and the other executive officers of the Company. The Board reviews and votes to approve all compensation decisions
involving the CEO and the executive officers of the Company. The Compensation Committee and the Board will use data, showing current
and historic elements of compensation, when reviewing executive officer and CEO compensation. The Committee is empowered to review
all components of executive officer and director compensation for consistency with the overall policies and philosophies of the
Company relating to compensation issues. The Committee may from time to time delegate duties and responsibilities to subcommittees
or a Committee member. The Committee may retain and receive advice, in its sole discretion, from compensation consultants. None
of the members of our Compensation Committee is one of our officers or employees.



None of our executive officers currently serves, or in the past
year has served, as a member of the board of directors or compensation committee of any entity that has one or more executive officers
serving on our Board or Compensation Committee.



Pursuant to its Charter, the Compensation Committee is authorized
to retain and terminate, without Board or management approval, the services of an independent compensation consultant to provide
advice and assistance. The Compensation Committee has the sole authority to approve the consultant’s fees and other retention
terms, and reviews the independence of the consultant and any other services that the consultant or the consultant’s firm
may provide to the company. The chair of the Compensation Committee reviews, negotiates and executes an engagement letter with
the compensation consultant. The compensation consultant directly reports to the Compensation Committee.



In May 2013, the Compensation Committee, following a
review of independence and conflict of interest factors, engaged Pay Governance LLC as its independent compensation
consultant. As part of its ongoing services to the Compensation Committee, the consultant supports the Compensation Committee
in executing its duties and responsibilities with respect to the Company’s compensation programs by providing
information regarding market trends and competitive compensation programs and strategies, including, among other things,
preparing market data for executive positions, assessing management recommendations for changes in the compensation
structure, working with management to ensure that the Company’s executive compensation programs are designed and
administered consistent with the Committee’s requirements, and provides ad hoc support to the Committee, including
discussing executive compensation and related corporate governance trends. Pay Governance provided an updated report in May 2014. Our human resources staff and senior management use the data provided by the consultant to prepare documents for
use by the Compensation Committee in preparing their recommendations to the full Board. Pay Governance provides no other
services to the Company.



Nominating and Governance Committee



The Nominating and Governance
Committee has the following responsibilities as set forth in its charter:



| | · | to review and recommend to the Board with regard to policies for the composition of the Board;
| | - | ----------------------------------------------------------------------------------------------



| | · | to review any director nominee candidates recommended by any director or executive officer of the
Company, or by any shareholder if submitted properly;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | to identify, interview and evaluate director nominee candidates and have sole authority to retain
and terminate any search firm to be used to assist the Committee in identifying director candidates and approve the search firm’s
fees and other retention terms;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | to recommend to the Board the slate of director nominees to be presented by the Board;
| | - | --------------------------------------------------------------------------------------



| | · | to recommend director nominees to fill vacancies on the Board, and the members of each Board committee;
| | - | -------------------------------------------------------------------------------------------------------





10







| | · | to lead the annual review of Board performance and effectiveness and make recommendations to the
Board as appropriate; and
| | - | --------------------------------------------------------------------------------------------------------------------------



| | · | to review and recommend corporate governance policies and principles for the Company, including
those relating to the structure and operations of the Board and its committees.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Dr. Keith is the Chairman
of this Committee, with Messrs. Del Guercio and Winzer being the other two members of the Committee. Shareholders meeting the following
requirements who want to recommend a director candidate may do so in accordance with our Bylaws and the following procedures established
by the Nomination and Governance Committee. The Board will consider all director candidates recommended to the Nomination and Governance
Committee by shareholders owning at least 5% of our outstanding shares at all times during the year preceding the date on which
the recommendation is made that meet the qualifications established by the Board. To make a nomination for director at an Annual
Meeting, a written nomination solicitation notice must be received by the Nomination and Governance Committee at our principal
executive office not less than 120 days before the anniversary date our proxy statement was mailed to shareholders in connection
with our previous annual meeting. The written nomination solicitation notice must contain the following material elements, as well
as any other information reasonably requested by us or the Nomination and Governance Committee:



| | · | the name and address, as they appear on our books, of the stockholder giving the notice or of the
beneficial owner, if any, on whose behalf the nomination is made;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | a representation that the stockholder giving the notice is a holder of record of our common stock
entitled to vote at the annual meeting and intends to appear in person or by proxy at the annual meeting to nominate the person
or persons specified in the notice;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | complete biography of the nominee, as well as consents to permit us to complete any due diligence
investigations to confirm the nominee’s background, as we believe to be appropriate;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | the disclosure of all special interests and all political and organizational affiliations of the
nominee;
| | - | ---------------------------------------------------------------------------------------------------------



| | · | a signed, written statement from the director nominee as to why the director nominee wants to serve
on our Board, and why the director nominee believes that he or she is qualified to serve;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | a description of all arrangements or understandings between or among any of the stockholder giving
the notice, the beneficial owner, if any, on whose behalf the notice is given, each nominee and any other person or persons (naming
such person or persons) pursuant to which the nomination or nominations are to be made by the stockholder giving the notice;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | such other information regarding each nominee proposed by the stockholder giving the notice as
would be required to be included in a proxy statement filed pursuant to the proxy rules of the SEC had the nominee been nominated
by our Board; and
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | the signed consent of each nominee to serve as a director if so elected.
| | - | ------------------------------------------------------------------------



In considering director candidates,
the Nomination and Governance Committee will consider such factors as it deems appropriate to assist in developing a Board and
committees that are diverse in nature and comprised of experienced and seasoned advisors who can bring the benefit of various backgrounds,
skills and insights to the Company and its operations. Candidates whose evaluations are favorable are then chosen by the Nominating
and Governance Committee to be recommended for selection by the full Board. The full Board selects and recommends candidates for
nomination as directors for stockholders to consider and vote upon at the annual meeting. Each director nominee is evaluated in
the context of the full Board’s qualifications as a whole, with the objective of establishing a Board that can best perpetuate
our success and represent stockholder interests through the exercise of sound judgment. Each director nominee will be evaluated
considering the relevance to us of the director nominee’s skills and experience, which must be complimentary to the skills
and experience of the other members of the Board. The Nominating and Governance Committee does not have a formal policy with regard
to the consideration of diversity in identifying director candidates, but seeks a diverse group of candidates who possess the background,
skills and expertise to make a significant contribution to the Board, to the Company and its shareholders.





11







Code of Conduct and Ethics



In April 2005, the Board approved a Code of Conduct and Ethics
applicable to all directors, officers and employees which complies with Item 406 of Regulation S-K. A copy of this Code of Conduct
and Ethics is available at the Company’s website at www.nuot.com, and is available at no charge by contacting the
Company at its headquarters as listed on the cover page of this Annual Report. Information appearing on the Company’s website
is not part of this Annual Report.



Board Oversight of Risk Management



Our Board does not have a policy regarding the separation of
the roles of Chief Executive Officer and Chairman of the Board as the Board believes it is in the best interests of the Company
to make that determination based on the position and direction of the Company and the membership of the Board. Independent directors
and management have different perspectives and roles in strategy development. The Company’s independent directors bring experience,
oversight and expertise from outside the company and industry, while the Chief Executive Officer brings company-specific experience
and expertise. Currently, the offices of the Executive Chairman of the Board and the Chief Executive Officer of the Company are
held by David Jorden and Martin P. Rosendale, respectively. We believe that this arrangement served the best interest of the Company
and its shareholders.



The Board sees its role in the Company’s risk oversight
process in receiving regular reports from members of senior management on areas of material risk to the Company, including strategic,
operational, reporting and compliance risks. The full Board (or the appropriate standing committee of the Board in the case of
risks that are under the purview of a particular committee) is to receive these reports from the appropriate party within the organization
that is responsible for a particular risk or set of risks to enable it to understand our risk identification, management and mitigation
strategies. The Board has developed an agenda of risk topics that are presented to the Board or one of its standing committees
on an annual basis. When a committee receives such a report, the Chairman of the committee will discuss the report with the full
Board during the next available Board meeting, holding additional meetings, if and when required. The Board believes that this
practice enables the Board and its committees to coordinate risk oversight for the Company, particularly regarding the interrelationship
among various risks. During its regular course of its activities, our Audit Committee discusses our policies with respect to risk
assessment and risk management. The Compensation Committee and the Board each discuss the relationship between our compensation
policies and corporate risk to assess whether these policies encourage excessive risk-taking by executives and other employees.



Process for Communicating with Board Members



We have no formal
written policy regarding communication with the Board. Persons wishing to write to the Board or to a specified director or
committee of the Board should send correspondence to the Secretary at our principal offices. Electronic submissions of
shareholder correspondence will not be accepted. The Secretary will forward to the directors all communications that, in his
judgment, are appropriate for consideration by the directors. Examples of communications that would not be appropriate for
consideration by the directors include commercial solicitations and matters not relevant to the shareholders, to the
functioning of the Board, or to the affairs of Nuo Therapeutics. Any correspondence received that is addressed generically to the Board
will be forwarded to the Chairman of the Board. If the Chairman of the Board is not an independent director, a copy will be
sent to the Chairman of the Audit Committee as well.



Section 16(a) Beneficial Ownership Reporting Compliance



Section 16(a) of the Exchange Act, requires officers, directors
and persons who own more than ten percent of a registered class of equity securities to, within specified time periods, file certain
reports of ownership and changes in ownership with the SEC.





12







Based solely upon a review of Forms 3 and Forms 4 furnished
to the Company pursuant to Rule 16a-3 under this Exchange Act during the Company’s most recent fiscal year, and Forms 5 with
respect to the most recent fiscal year, the Company believes that all such forms required to be filed pursuant to Section 16(a)
were timely filed as necessary by the executive officers, directors and security holders required to file same during the fiscal
year ended December 31, 2014 other than one Form 4 for each of Joseph Del Guercio and Mark McLoughlin, which were filed late, each
reporting one transaction, and one Form 4 filed late by Aldagen Holdings, LLC reporting four transactions.



ITEM 11. Executive Compensation



This discussion focuses on the compensation paid to “named
executive officers,” which is a defined term generally encompassing all persons that served as principal executive officer
at any time during the fiscal year, as well as certain other highly paid executive officers serving in such positions at the end
of the fiscal year. During 2014, the named executive officers consisted of the following persons:



| | · | Martin P. Rosendale — Chief Executive Officer (Principal Executive Officer)
| | - | ---------------------------------------------------------------------------



| | · | Steven A. Shallcross — Chief Financial Officer (Principal Financial and Accounting Officer)
| | - | -------------------------------------------------------------------------------------------



| | · | Dean Tozer— Chief Commercial Officer (effective April 2014)
| | - | -----------------------------------------------------------



Summary Compensation Table



|Name and Principal Position                         |  | Year |      |  | Salary |   |         | Bonus |  |   | Option Awards (4) |  |  | All Other Compensation |         |  | Total |  
|--------------------------------------------------- |  | ---- | ---- |  | ------ | - | ------- | ----- |  | - | ----------------- |  |  | ---------------------- | ------- |  | ----- | -
|                                                    |  |      |      |  |        |   |         |       |  |   |                   |  |  |                        |         |  |       |  
|Martin P. Rosendale(1)                              |  |      | 2014 |  |        | $ | 385,000 |       |  | $ | —                 |  |  | $                      | 104,730 |  |       | $
|Chief Executive Officer                             |  |      | 2013 |  |        | $ | 376,250 |       |  | $ | 91,000            |  |  | $                      | —       |  |       | $
|                                                    |  |      |      |  |        |   |         |       |  |   |                   |  |  |                        |         |  |       |  
|Steven A. Shallcross(2)                             |  |      | 2014 |  |        | $ | 290,000 |       |  | $ | 60,000            |  |  | $                      | 104,730 |  |       | $
|Chief Financial Officer (Effective May 10, 2013)    |  |      | 2013 |  |        | $ | 185,278 |       |  | $ | —                 |  |  | $                      | 270,240 |  |       | $
|                                                    |  |      |      |  |        |   |         |       |  |   |                   |  |  |                        |         |  |       |  
|Dean Tozer(3)                                       |  |      | 2014 |  |        | $ | 225,000 |       |  | $ | —                 |  |  | $                      | 519,915 |  |       | $
|Chief Commercial Officer (Effective March 30, 2014) |  |      |      |  |        |   |         |       |  |   |                   |  |  |                        |         |  |       |  



| | (1) | Martin P. Rosendale, CEO: Mr. Rosendale’s employment agreement, as amended, provides for his at-will employment as the
Company’s Chief Executive Officer. Effective June 1, 2012, Mr. Rosendale’s annual salary was $350,000 and his target
bonus percentage was 50%, depending on the achievement of performance criteria. This compensation is subject to annual review and
modification by the Board of Directors. If Mr. Rosendale’s employment is terminated by the Company, he is entitled to receive
a lump sum severance payment of $50,000. Effective as of May 14, 2014, the Company and Mr. Rosendale executed employment agreement
with Mr. Rosendale, which, among others, approved the terms and provisions of Mr. Rosendale’s continued employment with the
Company for a twelve month term (which is renewable automatically for twelve-month terms unless terminated in accordance with the
terms of the agreement) to include, among others: (i) base salary of $385,000 per annum, subject to review by the Board for subsequent
increases on a periodic basis; (ii) an opportunity to earn an annual bonus in the amount of up to 50% of his annual base salary,
subject to the Board’s review and approval, (iii) reimbursement of reasonable business expenses, and (iv) provisions relating
to termination of his employment with or without cause as well as terminations for change in control of the Company. In addition,
the foregoing agreement also contains non-solicitation, non-disparagement, noncompetition and other covenants and provisions customary
for agreements of this nature. The amount under Option Awards represent the grant date fair value of the option awarded on April
8, 2014 under the Company’s Equity Incentive Plan to purchase 300,000 shares of the Company’s common stock at an exercise
price of $0.60 per share, the closing price of the Company’s common stock on the date of the award. No stock options were
awarded in 2013. Amounts in All Other Compensation reflect employer 401(k) matching contributions.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------





13







| | (2) | Steven S. Shallcross, CFO, Executive VP, Secretary and Treasurer: On May 23, 2014, the Board approved the Company’s execution
of employment agreement with Mr. Shallcross (with the effective date of each as of May 30, 2014), the terms and provisions of which
include Mr. Shallcross’ continued employment with the Company to include, among others: (i) base salary of $290,000 per annum,
subject to review by the Board for subsequent increases on an annual basis; (ii) an opportunity to earn an annual bonus in the
amount of up to 40% of his annual base salary, subject to the Board’s review and approval, and (iii) provisions relating
to termination of his employment with or without cause as well as terminations for change in control of the Company. In addition,
the foregoing agreement also contains non-solicitation, non-disparagement, noncompetition and other covenants and provisions customary
for agreements of this nature. The amount under Option Awards represent the grant date fair value of 600,000 options awarded during
2013 and in 2014 the amount represents the grant date fair value of an April 8, 2014 grant of stock options awarded under the Company’s
Equity Incentive Plan to purchase 300,000 shares of the Company’s common stock at an exercise price of $0.60 per share, the
closing price of the Company’s common stock on the date of the award. Mr. Shallcross has tendered his resignation to the
Board effective as of May 24, 2015.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | Dean Tozer, CCO: On May 23, 2014, the Board approved the Company’s execution of employment agreement with Mr. Tozer,
which terms and provisions of Mr. Tozer’s continued employment with the Company for the 30-month term to include, among others:
(i) base salary of $300,000 per annum, subject to review by the Board for subsequent increases on an annual basis; (ii) an opportunity
to earn an annual bonus in the amount of up to 40% of his annual base salary, subject to the Board’s review and approval,
and (iii) provisions relating to termination of his employment with or without cause as well as terminations for change in control
of the Company. In addition, the foregoing agreement also contains non-solicitation, non-disparagement, non-competition and other
covenants and provisions customary for agreements of this nature. As previously disclosed, the Board appointed Mr. Tozer as the
Company’s CCO on March 30, 2014, commencing as of April 1, 2014. Amount under Option Awards represent the grant date fair
value of the April 8, 2014 grant of stock options awarded under the Company’s 2013 Equity Incentive Plan to purchase 350,000
shares of the Company’s common stock at an exercise price of $0.60 per share, the closing price of the Company’s common
stock on the date of the award. In addition, it also includes the grant date fair value of the July 17, 2014 grant of stock options
awarded under the Company’s 2002 Long Term Incentive Plan to purchase 1,000,000 shares of the Company’s common stock
at an exercise price of $0.60 per share, the closing price of the Company’s common stock on April 8, 2014. Amounts in All
Other Compensation reflect employer 401(k) matching contributions. Mr. Tozer was paid $137,500 in 2014 for services performed prior
to March 31, 2014, $62,500 for 2013 consulting fees and $75,000 for 2014 consulting fees. In addition, Mr. Tozer received a warrant
to purchase 100,000 shares of the Company’s common stock on October 15, 2013.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (4) | Represents the fair value of the stock option awards granted during the fiscal year, calculated in accordance with FASB ASC
Topic 718. All equity-based compensation is estimated on the date of grant using the Black-Scholes-Merton option-pricing formula
which uses various assumptions. The expected volatilities used in the model are based on the historical volatility of the Company’s
stock. The Company uses peer company data to estimate option exercise and employee termination within the valuation model. The
expected years until exercise represents the period of time that options are expected to be outstanding and was estimated by using
peer company information. The risk-free rate for periods within the contractual life of the option is based on the U.S. Treasury
yield curve in effect at the time of grant. The Company estimated that the dividend rate on its Common stock will be zero.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Employment Contracts and Termination of Employment and
Change-in-Control Arrangements



The Company has employment agreements with the following named
executive officers. The following is a description of these agreements.



Martin P. Rosendale, CEO: Mr. Rosendale’s
employment agreement, as amended, provides for his at-will employment as the Company’s Chief Executive Officer. Effective
June 1, 2012, Mr. Rosendale’s annual salary was $350,000 and his target bonus percentage was 50%, depending on the achievement
of performance criteria. This compensation is subject to annual review and modification by the Board of Directors. If Mr. Rosendale’s
employment is terminated by the Company, he is entitled to receive a lump sum severance payment of $50,000. Effective as of May
14, 2014, the Company and Mr. Rosendale executed employment agreement with Mr. Rosendale, which, among others, approved the terms
and provisions of Mr. Rosendale’s continued employment with the Company for a twelve month term (which is renewable automatically
for twelve-month terms unless terminated in accordance with the terms of the agreement) to include, among others: (i) base salary
of $385,000 per annum, subject to review by the Board for subsequent increases on a periodic basis; (ii) an opportunity to earn
an annual bonus in the amount of up to 50% of his annual base salary, subject to the Board’s review and approval, (iii) reimbursement
of reasonable business expenses, and (iv) provisions relating to termination of his employment with or without cause as well as
terminations for change in control of the Company. In addition, the foregoing agreement also contains non-solicitation, non-disparagement,
noncompetition and other covenants and provisions customary for agreements of this nature.





14







Steven S. Shallcross, CFO, Executive VP, Secretary and
Treasurer: On May 23, 2014, the Board approved the Company’s execution of employment agreement with Mr. Shallcross
(with the effective date of each as of May 30, 2014), the terms and provisions of which include Mr. Shallcross’ continued
employment with the Company to include, among others: (i) base salary of $290,000 per annum, subject to review by the Board for
subsequent increases on an annual basis; (ii) an opportunity to earn an annual bonus in the amount of up to 40% of his annual base
salary, subject to the Board’s review and approval, and (iii) provisions relating to termination of his employment with or
without cause as well as terminations for change in control of the Company. In addition, the foregoing agreement also contains
non-solicitation, non-disparagement, noncompetition and other covenants and provisions customary for agreements of this nature.
Mr. Shallcross has tendered his resignation to the Board effective as of May 24, 2015.



Dean Tozer, CCO: On May 23, 2014, the Board approved
the Company’s execution of employment agreement with Mr. Tozer, which terms and provisions of Mr. Tozer’s continued
employment with the Company for the 30-month term to include, among others: (i) base salary of $300,000 per annum, subject to review
by the Board for subsequent increases on an annual basis; (ii) an opportunity to earn an annual bonus in the amount of up to 40%
of his annual base salary, subject to the Board’s review and approval, and (iii) provisions relating to termination of his
employment with or without cause as well as terminations for change in control of the Company. In addition, the foregoing agreement
also contains non-solicitation, non-disparagement, non-competition and other covenants and provisions customary for agreements
of this nature. As previously disclosed, the Board appointed Mr. Tozer as the Company’s CCO on March 30, 2014.



Outstanding Equity Awards at December
31, 2014





|Name                 |  | Number of Securities Underlying Unexercised Options Exercisable(1) |         |  | Number of Securities Underlying Unexercised Options Unexercisable |  |           |  | Option Exercise Price |  |   | Option Expiration Date
|-------------------- |  | ------------------------------------------------------------------ | ------- |  | ----------------------------------------------------------------- |  | --------- |  | --------------------- |  | - | ----------------------
|Martin P. Rosendale  |  |                                                                    | 200,000 |  |                                                                   |  | —         |  |                       |  | $ | 1.54                  
|                     |  |                                                                    | 300,000 |  |                                                                   |  | —         |  |                       |  | $ | 0.75                  
|                     |  |                                                                    | 200,000 |  |                                                                   |  | —         |  |                       |  | $ | 0.40                  
|                     |  |                                                                    | 165,000 |  |                                                                   |  | —         |  |                       |  | $ | 0.56                  
|                     |  |                                                                    | 150,000 |  |                                                                   |  | —         |  |                       |  | $ | 0.80                  
|                     |  |                                                                    | 200,000 |  |                                                                   |  | 100,000   |  | (2)                   |  | $ | 0.60                  
|Steven A. Shallcross |  |                                                                    | 200,000 |  |                                                                   |  | 400,000   |  | (3)                   |  | $ | 0.51                  
|                     |  |                                                                    | 200,000 |  |                                                                   |  | 100,000   |  | (2)                   |  | $ | 0.60                  
|Dean Tozer           |  |                                                                    | 233,333 |  |                                                                   |  | 116,667   |  | (4)                   |  | $ | 0.60                  
|                     |  |                                                                    | —       |  |                                                                   |  | 1,000,000 |  | (5)                   |  | $ | 0.60                  





| | (1) | All options are fully vested.
| | --- | -----------------------------



| | (2) | These options vested as follows: 25,000 each on January 8, 2015, February 8, 2015, March 8, 2015 and April 8, 2015.
| | --- | -------------------------------------------------------------------------------------------------------------------



| | (3) | 200,000 options vested on March 30, 2015 and 200,000 will vest on March 30, 2016.
| | --- | ---------------------------------------------------------------------------------



| | (4) | These options vested in equal increments on the 8th of January, February, March and April 2015.
| | --- | -----------------------------------------------------------------------------------------------



| | (5) | 164,000 of these options vested on April 8, 2015. The remaining awards vest 41,800 monthly for twenty months on the 8thof each month until December 8, 2016.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------



The Company does not provide
any pension plans/benefits or nonqualified deferred compensation.





15







Director Compensation in 2014



For service during 2014, each non-employee director was entitled
to and received options to purchase 30,000 shares of the Company’s common stock and, in addition, each committee chair was
entitled to and received options to purchase 10,000 shares of the Company’s Common stock.



|Name               |  | Fees Earned or Paid in Cash(1) |        |  | Option
 Awards(2) |   |        | All Other Compensation |  |   | Total   | 
|------------------ |  | ------------------------------ | ------ |  | ----------------- | - | ------ | ---------------------- |  | - | ------- | 
|David E. Jorden(3) |  | $                              | —      |  |                   | $ | —      |                        |  | $ | 100,000 | 
|                   |  |                                |        |  |                   |   |        |                        |  |   |         | 
|Joseph Del Guercio |  | $                              | 25,000 |  |                   | $ | 16,341 |                        |  | $ | —       | 
|                   |  |                                |        |  |                   |   |        |                        |  |   |         | 
|Lyle A. Hohnke     |  | $                              | 28,750 |  |                   | $ | 21,788 |                        |  | $ | —       | 
|                   |  |                                |        |  |                   |   |        |                        |  |   |         | 
|Richard S. Kent(4) |  | $                              | 25,000 |  |                   | $ | 16,341 |                        |  | $ | —       | 
|                   |  |                                |        |  |                   |   |        |                        |  |   |         | 
|Stephen N. Keith   |  | $                              | 30,000 |  |                   | $ | 21,788 |                        |  | $ | —       | 
|                   |  |                                |        |  |                   |   |        |                        |  |   |         | 
|Mark T. McLoughlin |  | $                              | 26,250 |  |                   | $ | 16,341 |                        |  | $ | —       | 
|                   |  |                                |        |  |                   |   |        |                        |  |   |         | 
|C. Eric Winzer     |  | $                              | 35,000 |  |                   | $ | 21,788 |                        |  | $ | —       | 
|                   |  |                                |        |  |                   |   |        |                        |  |   |         | 

| | (1) | The amounts reflected in this column represent the cash fees paid to non-executive Directors for services during 2014.
                                                            Of                                                             these amounts, the following amounts were paid in 2014 with
                                                            respect to 2013 services: Del Guercio: $6,250, Hohnke: $6,250,
                                                            Kent: $6,250, Keith: $7,500, McLoughlin: $7,200 and Winzer: $8,750. The amounts reflected in this column do not include the
                                                            following                                                             cash payments made to Directors in 2015 for 2014
                                                            services: Del Guercio: $10,000, Hohnke: $12,500, Kent: $10,000, Keith: $12,500, McLoughlin:
                                                            $10,000 and Winzer: $13,750.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Represents the fair value of the stock option awards granted during the fiscal year, calculated in accordance with FASB
                                                            ASC Topic 718. All equity-based compensation is estimated on the date of grant using the Black-Scholes-Merton option-pricing
                                                            formula which uses various assumptions. The expected volatilities used in the model are based on the historical volatility
                                                            of                                                             the Company’s stock. The Company used company data to
                                                            estimate option exercise and anticipated employee terminations
                                                            within the valuation model. The expected years until exercise represents the period of time that options are expected to be
                                                            outstanding and was estimated by using company information. The risk-free rate for periods within the contractual life of
                                                            the                                                             option is based on the U.S. Treasury yield curve in effect at
                                                            the time of grant. The Company estimated that the dividend rate
                                                            on its common stock will be zero. At December 31, 2014, the following number of stock options remained unexercised by
                                                            non-employee directors as follows: Jorden — 180,000, Del Guercio — 90,000,
                                                            Hohnke — 575,000,
                                                            Keith — 240,000, McLoughlin — 390,000, Winzer  — 240,000.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------





| | (3) | Mr. Jorden is an executive member of
                                                                                                                                            management in addition to serving on the Board as Executive Chairman. He is not compensated for his Board service. No stock
                                                                                                                                            options were awarded in 2014. The amount in the “All Other Compensation” column represents his cash compensation
                                                                                                                                            in 2014. Mr. Jorden has agreed to accept the position of Acting Chief Financial Officer of the Company, a
                                                                                                                                            role
                                                                                                                                            which he will officially assume effective as of May 25, 2015 and in connection therewith will give up his role as Executive
                                                                                                                                            Chairman but
                                                                                                                                            will
                                                                                                                                            continue to serve
                                                                                                                                            as
                                                                                                                                            a
                                                                                                                                            member
                                                                                                                                            of the Board of Directors. Commencing May 1, 2015, the Company will compensate Mr. Jorden at the rate of $200,000 for
                                                                                                                                            as long as he serves as Acting Chief Financial Officer.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (4) | Mr. Kent resigned from the Board of Directors on December
31, 2014.
| | --- | -------------------------------------------------------------------



In May 2013, the Board’s Compensation
Committee engaged Pay Governance LLC, an outside compensation consultation expert, to conduct an overall assessment of
the non-management director compensation levels to assess the competitive positioning of the Company’s program for
such directors. In its review, the experts considered, among other factors, annual Board committee retainers and per meeting
fees, chair premium/incremental fees, annualized expected value of stock-based compensation, and actual total cash
compensation. Following its review, the experts concluded that Nuo Therapeutics director compensation was generally aligned
with (or slightly below) market practices. In June 2013, the Board reviewed the Compensation Committee report based upon the
foregoing expert conclusions and adopted the Committee recommendation to leave the director compensation unchanged as it was
currently in place. Based on feedback from the Board of Directors along with guidelines provided by a Pay Governance report
received in May 2014, the Compensation Committee proposed and the Board of Directors approved the following changes to
Outside Director Compensation:





16







1.	Annual cash retainer of $40,000 (Up from $25,000) with
a start date of October 1, 2014 vs. January 1, 2015



2.	Annual equity grant to deliver 45,000 options (Up from
30,000) along with the elimination of annual equity grant of 10,000 options for committee chairs



3.	Committee chair fees of $15,000, $10,000 & $10,000
for Audit, Compensation & Governance/Nominating Committee, respectively (Up from $10,000, $5,000, $5,000, respectively)



4.	No “Per Meeting” fees paid for board or committee
meetings but $1,500 per “minuted” board meetings exceeding 10/year.



5.	Effective start date: October 1, 2014



ITEM 12. Security Ownership of Certain Beneficial Owners
and Management and Related Stockholder Matters



Securities Authorized for Issuance under Equity Compensation
Plans



We believe that the making of awards under equity compensation
plans promotes the success and enhances our value by providing the awardee with an incentive for outstanding performance. Our equity
compensation plans are further intended to provide flexibility to us in our ability to motivate, attract, and retain the services
of personnel upon whose judgment, interest, and special effort the successful conduct of our operation is largely dependent.



2002 Long Term Incentive Plan



As of December 31, 2014, our Long-Term Incentive Plan (“LTIP”)
is authorized for issuance of up to 10,500,000 shares of Common stock. The LTIP permits awards of stock options, SARs, restricted
stock, phantom stock, performance units, dividend equivalents or other stock-based awards to our employees, officers, consultants,
independent contractors, advisors, and directors. As of July 2013, incentive stock options may no longer be granted under the LTIP.



2013 Equity Incentive Plan



As of December 31, 2014, our 2013 Equity Incentive Plan ("EIP")
is authorized for issuance of up to 18,000,000 shares of Common stock. At the special meeting of shareholder held on June 9, 2014,
the Company’s shareholders approved a proposed amendment to the 2013 EIP to increase the number of shares of common stock
authorized to be issued under the Plan from 3.0 million shares to 18.0 million shares. The EIP permits awards of stock options,
SARs, restricted stock, phantom stock, performance units, dividend equivalents or other stock-based awards to our employees, officers,
consultants, independent contractors, advisors, and directors.



Equity Compensation Plan Information
as of December 31, 2014



|Plan
    category                                                 |  | Number
    of securities to be issued upon exercise of outstanding options, warrants, and rights |            |  | Weighted
    average exercise price of outstanding options, warrants, and rights |   |      | Number
    of securities remaining available for future issuance | 
|----------------------------------------------------------------- |  | ------------------------------------------------------------------------------------------------ | ---------- |  | -------------------------------------------------------------------------------- | - | ---- | ---------------------------------------------------------------- | 
|Equity compensation
    plans approved by security holders        |  |                                                                                                  | 14,205,625 |  |                                                                                  | $ | 0.80 |                                                                  | 
|Equity compensation plans
    not approved by security holders(1) |  |                                                                                                  | 1,481,364  |  |                                                                                  | $ | 1.20 |                                                                  | 
|Total                                                             |  |                                                                                                  | 15,686,989 |  |                                                                                  | $ | 0.84 |                                                                  | 
|                                                                  |  |                                                                                                  |            |  |                                                                                  |   |      |                                                                  | 

| | (1) | These amounts represent the aggregate of individual compensation arrangements with external service providers.
| | --- | --------------------------------------------------------------------------------------------------------------



As of December 31, 2014, 531,802 shares of Common stock have
been issued upon exercise of options granted pursuant to the LTIP and no shares of Common stock have been issued upon exercise
of options granted pursuant to the EIP.





17







Security Ownership of Certain Beneficial Owners



The following table sets forth information regarding the
ownership of our Common stock as of April 17, 2015 by all those known by the Company to be beneficial owners of more than
five percent of its Common stock. This table is prepared in reliance upon beneficial ownership statements filed by such
shareholders with the SEC under Section 13(d) or 13(g) of the Exchange Act and/or the best information available to the
Company.



|Name
    of Beneficial Owner                        |  | Beneficial
    Ownership(1) |            |     | Percent
    of Class(1) | 
|--------------------------------------------------- |  | --------------------------- | ---------- | --- | ----------------------- | 
|Aldagen Holdings,
    LLC                           |  |                             | 14,298,934 | (2) |                         | 
|Deerfield Private Design
    Fund II, L.P.          |  |                             | 50,048,779 | (3) |                         | 
|Deerfield Private Design
    International II, L.P. |  |                             | 57,352,034 | (3) |                         | 
|Deerfield Special Situations
    Fund, L.P.         |  |                             | 55,327,691 | (3) |                         | 
|John Paul DeJoria                                   |  |                             | 9,212,306  | (4) |                         | 
|Charles E. Sheedy                                   |  |                             | 8,071,000  | (5) |                         | 
|                                                    |  |                             |            |     |                         | 

| | (1) | Percentage ownership is based upon 125,680,100 shares of common stock issued and outstanding as of April 17, 2015. For purposes
of determining the amount of securities beneficially owned, share amounts include all common stock owned outright plus all shares
of common stock issuable upon conversion of convertible notes, or the exercise of options or warrants currently exercisable, or
exercisable within 60 days after the preparation of this table. We believe that, except as otherwise noted below, each named beneficial
owner has sole voting and investment power with respect to the shares listed. There are no arrangements, known to the Company,
including any pledge by any person of securities of the registrant, the operation of, which may, at a subsequent date, result in
a change of control of the registrant. This table is prepared in reliance upon beneficial ownership statements filed by such shareholders
with the SEC under Section 13(d) or 13(g) of the Exchange Act and/or the best information available to the Company.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Aldagen Holdings, LLC’s beneficial ownership of the Company’s securities includes 14,120,752 shares of Common stock
and 178,182 shares of Common stock issuable upon exercise of warrants held by Aldagen Holdings. Mailing address for Aldagen Holdings
custodian, Synovus Trust Company, 800 Shades Creek Parkway, Suite 225, Birmingham, AL 35209.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | James E. Flynn, with an address at 780 Third Avenue, 37th Floor, New York, New York 10017, has voting and dispositive
                                                            power over these securities. Includes warrants to purchase an aggregate of 92,615,384 shares of common stock and an
                                                            aggregate                                                             of 70,113,120 shares of common stock, held by each of
                                                            the listed entities of which Deerfield Management Company, L.P. is the
                                                            investment advisor. The amounts also include the conversion of accrued interest into share of common stock through the date
                                                            reported in the filing of the Schedule 13G by such listed entities. The
                                                            Deerfield                                                             stockholders
                                                            disclaim                                                             beneficial
                                                            ownership of                                                                                                 our
                                                            common                                                                      stock
                                                            that                                                                                                          exceeds
                                                            9.98% of                                                               our
                                                            outstanding common                                                                                                  stock.
                                                            Under the terms of the                                                             notes
                                                            and                                                                                                               the
                                                            warrants held by                                                             Deerfield, the number of
                                                            shares of our                                                                    common stock that may be acquired by
                                                            such stockholders upon any                                                             exercise of the warrants or
                                                            conversion                                                             of the notes is
                                                            limited to the extent necessary to ensure that, following such exercise or conversion, the total number of shares of our
                                                            common stock then beneficially owned by the stockholder, together with its affiliates and any other persons or entities
                                                            whose                                                             beneficial ownership of our common stock would be
                                                            aggregated with such selling stockholder for purposes of Section 13(d) of
                                                            the Exchange Act and the applicable regulations of the SEC, would not exceed 9.98% of the total number of shares of our
                                                            common stock then issued and outstanding. The 9.98% limitation is disregarded for purposes of determining the number of
                                                            shares of common stock beneficially owned, but is applied for purposes of determining percentage ownership.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------





18







| | (4) | Includes 8,116,085 shares of common stock and 1,096,221 shares of common stock issuable upon exercise of warrants and held
by Mr. DeJoria. Mailing address for Mr. DeJoria is 1888 Century Park East, Suite 1600, Century City CA 90067.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (5) | Mr. Sheedy’s beneficial ownership of the company’s securities includes 6,689,652 shares of common stock and 1,381,348
shares of common stock issuable upon exercise of warrants held by Mr. Sheedy. Mailing address for Mr. Sheedy is Two Houston Center,
Suite 2907, Houston TX 77010.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Security Ownership of Management



The following table sets forth information regarding the ownership
of our Common stock as of April 17, 2015: (i) each director; (ii) each of the named executive officers; and (iii) all executive
officers and directors of the Company as a group.



|Name of Beneficial Owner                             |  | Beneficial Ownership(1) |            |      | Percent of Class(1) | 
|---------------------------------------------------- |  | ----------------------- | ---------- | ---- | ------------------- | 
|Joseph Del Guercio                                   |  |                         | 1,608,884  | (2)  |                     | 
|                                                     |  |                         |            |      |                     | 
|Lyle A. Hohnke                                       |  |                         | 593,750    | (3)  |                     | 
|                                                     |  |                         |            |      |                     | 
|David E. Jorden                                      |  |                         | 7,284,194  | (4)  |                     | 
|                                                     |  |                         |            |      |                     | 
|Stephen N. Keith                                     |  |                         | 258,750    | (5)  |                     | 
|                                                     |  |                         |            |      |                     | 
|Mark T. McLoughlin                                   |  |                         | 428,751    | (6)  |                     | 
|                                                     |  |                         |            |      |                     | 
|Martin P. Rosendale                                  |  |                         | 1,544,149  | (7)  |                     | 
|                                                     |  |                         |            |      |                     | 
|Steven A. Shallcross                                 |  |                         | 779,500    | (8)  |                     | 
|                                                     |  |                         |            |      |                     | 
|Dean E. Tozer                                        |  |                         | 897,600    | (9)  |                     | 
|                                                     |  |                         |            |      |                     | 
|C. Eric Winzer                                       |  |                         | 258,750    | (10) |                     | 
|                                                     |  |                         |            |      |                     | 
|Group consisting of executive officers and directors |  |                         | 14,417,719 | (11) |                     | 



| | * | Less than 1%.
| | - | -------------



| | (1) | Percentage ownership is based upon 125,680,100 shares of Common stock issued and outstanding as of April 17, 2015. For purposes
of determining the amount of securities beneficially owned, share amounts include all Common stock owned outright plus all shares
of Common stock issuable upon conversion of convertible notes, or the exercise of options or warrants currently exercisable, or
exercisable within 60 days after the preparation of this table. Unless otherwise indicated, the mailing address of all persons
named in this table is: c/o Nuo Therapeutics, Inc., 207A Perry Parkway, Suite 1, Gaithersburg, MD 20877.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Independent director of the Company. Includes 1,143,770 shares of the Company’s Common stock owned directly by CNF Investments
II, LLC (“CNF”). The individual managing members (collectively, the “CNF Member Managers”) of CNF are Joseph
Del Guercio and Robert J. Flanagan. CNF and CNF Member Managers may share voting and dispositive power over the shares directly
held by CNF. Mr. Del Guercio is Managing Director of CNF. He disclaims beneficial ownership of such securities. Also includes
356,364 shares issuable upon exercise of the warrant also held by CNF and 108,750 shares Mr. Del Guercio may acquire upon
the exercise of stock options approved by the Board and issued under the Company’s 2002 Long-Term Incentive Plan and 2013
Equity Incentive Plan. Mailing address for CNF is 7500 Old Georgetown Road, 15th Floor, Bethesda, MD 20814.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------





19







| | (3) | Independent director of the Company. Includes 593,750 shares Mr. Hohnke may acquire upon the exercise of stock options
approved by the Board and issued under the Company’s 2002 Long-Term Incentive Plan and 2013 Equity Incentive Plan.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (4) | Executive Chairman of the Board of the Company. Includes 180,000 shares Mr. Jorden may acquire upon the exercise of stock
options approved by the Board and issued under the Company’s 2002 Long-Term Incentive Plan and 199,194 shares issuable upon
the exercise of warrants.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (5) | Independent director of the Company. Includes 258,750 shares Dr. Keith may acquire upon the exercise of stock options approved
by the Board and issued under the Company’s 2002 Long-Term Incentive Plan and 2013 Equity Incentive Plan.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (6) | Independent director of the Company. Includes 408,750 shares Mr. McLoughlin may acquire upon the exercise of stock options
approved by the Board and issued under the Company’s 2002 Long-Term Incentive Plan and 2013 Equity Incentive Plan.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (7) | Chief Executive Officer of the Company. Includes 1,315,000 shares Mr. Rosendale may acquire upon the exercise of stock
options approved by the Board and issued under the Company’s 2002 Long-Term Incentive Plan and 2013 Equity Incentive Plan.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (8) | Chief Financial Officer of the Company. Includes 700,000 shares Mr. Shallcross may acquire upon the exercise of stock options
approved by the Board and issued under the Company’s 2002 Long-Term Incentive Plan and the 2013 Equity Incentive Plan, 400,000
of which have vested and are exercisable until March 30, 2023 and 300,000 of which have vested and must be exercised within 90
days of the effective date of his resignation.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



(9)Appointed the Company’s
Executive Vice President and Chief Commercial Officer on March 31, 2014 commencing as of April 1, 2014. Includes 597,600 shares
Mr. Tozer may acquire upon the exercise of stock options approved by the Board under the 2002 Long-Term Incentive Plan and 2013
Equity Incentive Plan and 100,000 shares Mr. Tozer may acquire upon the exercise of warrants.



| | (10) | Independent director of the Company. Includes 258,750 shares Mr. Winzer may acquire upon the exercise of stock options
approved by the Board and issued under the Company’s 2002 Long-Term Incentive Plan and 2013 Equity Incentive Plan.
| | ---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (11) | Includes options and warrants to purchase an aggregate of 5,644,408 shares of common stock.
| | ---- | -------------------------------------------------------------------------------------------



There are no arrangements, known to the Company, including any
pledge by any person of securities of the registrant, the operation of, which may, at a subsequent date, result in a change of
control of the registrant.



ITEM 13. Certain Relationships and Related Transactions,
and Director Independence



Except as set forth below, during the 2013 and 2014 fiscal years,
we were not involved in any related party transactions subject to Item 404 of Regulation S-K.



In February 2013, the Company raised gross proceeds of $5,000,000,
before placement agent’s fees and other offering expenses, in a registered public offering. Proceeds from the transaction
were to be used for general corporate and working capital purposes. The securities purchase agreements in connection with this
offering provided for certain “piggy-back” registrations rights with respect to the Company’s securities (including
shares to be issued upon warrant exercises) purchased in the offering by investors that are affiliates of the Company, such that
the Company agreed, to the extent such affiliate investors are not able to resell such securities without restriction, to include
such securities in its future registration statements, subject to applicable limitations. Also, to the extent that such securities
have been not registered at the time the Company is required to file a registration statement in connection with the final milestone
event relating to the February 2012 Aldagen acquisition, the affiliate investors will have the right to include such securities
in such registration statement. The terms of the foregoing transaction, among other things, were disclosed in the Company’s
Current Report on Form 8-K filed with the SEC on February 20, 2013.





20







Also in February 2013, the Company and Aldagen Holdings, LLC,
a North Carolina limited liability company (“Aldagen Holdings”), executed an amendment (the “Amendment”)
to the February 8, 2012 Exchange and Purchase Agreement (the “Exchange Amendment”). The disinterested members of the
Board reviewed and approved the terms and provisions of the Amendment. The purpose of the Amendment was to modify the terms of
the post-closing consideration. The terms of the foregoing transaction, among other things, were disclosed in the Company’s
Current Report on Form 8-K filed with the SEC on February 20, 2013.



In February 2013, the Company and its wholly-owned subsidiary,
Cytomedix Acquisition Company, LLC, on the one hand, and the holder of the April 28, 2011 $2.1 million secured promissory
note (the “JP Trust Note”), JP’s Nevada Trust (the “Lender”), on the other hand, agreed, in consideration
for subordination of its security interest under the JP Trust Note to that of MidCap Bank pursuant to the terms of the Subordination
Agreement, to amend the terms of the outstanding JP Trust Note to extend the maturity date of such note to November 19, 2016, among
other things. As disclosed in the Company’s Current Report on Form 8-K relating to the original issuance of the JP Trust
Note, the Company’s payment obligations with respect to $1.4 million under the JP Trust Note were guaranteed by certain
insiders, affiliates, and shareholders of the Company, including David E. Jorden, Chairman of the Board of the Company (the “Guarantors”).
In light of the foregoing changes to the Lender’s warrant vesting schedule and issuance of new warrants the Lender, as described
above, the disinterested members of the Board also: (i) reviewed and approved amendments to the warrant vesting schedule on
the Guarantors’ warrants (including those held by Mr. Jorden) issued by the Company in April 2011 such that the remaining
500,000 warrant shares are exercisable immediately and (ii) granted the right to the Guarantors to acquire up to 533,334 shares
of the Company’s Common stock pursuant to warrants at the exercise price of $0.70 per share, vesting as follows: (i) 266,667
warrant shares may be exercised only if the JP Trust Note has not been prepaid by the fourth anniversary of its issuance, and (ii)
the remaining 266,667 shares may be exercised only if the JP Trust Note has not been paid by the fifth anniversary of its issuance
(including 107,143 of the previously issued warrants held by Mr. Jorden, which will now vest immediately, and (i) 57,143 of
his warrant shares may be exercised only if the JP Trust Note has not been paid by the fourth anniversary of its issuance, and
(ii) the remaining 57,143 shares may be exercised only if the JP Trust Note has not been paid by the fifth anniversary of its issuance).
The terms of the foregoing transaction, among other things, were disclosed in the Company’s Current Report on Form 8-K
filed with the SEC on February 20, 2013.



On November 11, 2014, the Company and Aldagen Holdings, LLC,
a North Carolina limited liability company (“Aldagen Holdings”), executed that certain Second Amendment (the “Second
Amendment”) to the February 8, 2012 Exchange and Purchase Agreement, as amended on February 8, 2013 (as amended to date,
the “Exchange Agreement”). All disinterested members of the Board reviewed and approved the terms and provisions of
the Second Amendment. Pursuant to the terms of the Second Amendment, the terms of the post-closing consideration originally contemplated
under the Exchange Agreement and structured around the achievement of certain milestone events relating to the Company’s
ALD-401 Phase 2 clinical trials were amended such that, in full satisfaction of all the post-closing issuance obligations of the
Company to Aldagen Holdings, the Company agreed to a one-time issuance of 1,270,000 shares of Nuo Therapeutics common stock (the
“Post-Closing Amended Shares”), out of the 20,309,723 shares of our common stock held in reserve, which were contingently
issuable upon the achievement of certain milestones related to the current ALD-401 Phase 2 clinical trial. In addition, the parties
to the Second Amendment agreed to terminate the originally contemplated registration requirements with respect to any post-closing
share issuance. The Second Amendment provides Aldagen Holdings with “piggy-back” registration rights with respect to
the Post-Closing Amended Shares for the duration of twelve months following the date of the Second Amendment such that the Company
will use its reasonable best efforts to include the Post-Closing Amended Shares in its registration statements to register the
resale of such shares by Aldagen Holdings. The Company issued the Post-Closing Amended Shares in reliance upon an exemption from
registration contained in Section 4(2) and Rule 506 under the Securities Act; such shares may not be offered or sold in the United
States absent registration or an applicable exemption from registration requirements.



Review and Approval Policies and Procedures for Related
Party Transactions



Pursuant to written Board policies, our executive officers and
directors, and principal stockholders, including their immediate family members and affiliates, are not permitted to enter into
a related party transaction without the prior consent of the Board. Any request for such related party transaction with an executive
officer, director, principal stockholder, or any of such persons’ immediate family members or affiliates, in which the amount
involved exceeds $120,000 must first be presented to the Audit Committee and the Board for review, consideration and approval.
All of our directors, executive officers and employees are required to report to the Board any such related party transaction.
In approving or rejecting the proposed agreement, the Board will consider the relevant facts and circumstances available and deemed
relevant to the Board which will approve only those agreements that, in light of known circumstances, are in, or are not inconsistent
with, our best interests, as the Board determines in the good faith exercise of its discretion.





21







Director Independence



The Company’s current directors include Stephen Keith,
Mark McLoughlin, David Jorden, Joseph Del Guercio, Lyle Hohnke, Martin Rosendale and Eric Winzer. The Company’s securities
are being quoted on the OTC Bulletin Board. The Board elects to apply the NASDAQ Stock Market corporate governance requirements
and standards in its determination of the independence status of each Board and Board committee member. All of the Company’s
current directors meet such independence requirements with the exception of Messrs. Rosendale and Jorden, neither of which individuals
serves on the Audit Committee of the Board. The members of the Audit Committee are also “independent” for purposes
of Section 10A-3 of the Exchange Act and NASDAQ Stock Marketplace rules. The Board based its independence determinations primarily
on a review of the responses of the directors and executive officers to questions regarding employment and transaction history,
affiliations and family and other relationships and on discussions with the directors. None of our directors engages in any transaction,
relationship, or arrangement contemplated under section 404(a) of Regulation S-K.



ITEM 14. Principal Accounting Fees and Services



The following table presents fees for professional services
rendered by Stegman & Company for the fiscal year 2014 and 2013:



|Services
    Performed |  | 2014 |         |  | 2013 |  
|---------------------- |  | ---- | ------- |  | ---- | -
|Audit fees(1)          |  | $    | 155,000 |  |      | $
|Audit-related fees(2)  |  |      | 1,200   |  |      |  
|Tax fees(3)            |  |      | 30,000  |  |      |  
|All other fees(4)      |  |      | —       |  |      |  
|Total Fees             |  | $    | 186,200 |  |      | $



| | (1) | Audit fees represent fees billed for professional services provided in connection with the audit of the Company’s annual
financial statements, reviews of its quarterly financial statements, and audit services provided in connection with statutory and
regulatory filings for those years.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Audit-related fees represent fees billed primarily for assurance and related services not reported under Audit fees.
| | --- | --------------------------------------------------------------------------------------------------------------------



| | (3) | Tax fees principally represent fees billed for tax preparation, tax advice and tax planning services.
| | --- | -----------------------------------------------------------------------------------------------------



| | (4) | All other fees principally would include fees billed for products and services provided by the accountant, other than the services
reported under the three captions above.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Pursuant to its charter, the Audit Committee must pre-approve
audit services and permitted non-audit services (including the fees and terms thereof) to be performed for the Company by its independent
auditor. In 2014 and 2013, all such services were pre-approved by the Audit Committee.



Audit Committee Pre-Approval Policies and Procedures



The Audit Committee has the sole authority to pre-approve all
audit and non-audit services provided by independent accountants. The Audit Committee has adopted policies and procedures for the
pre-approval of services provided by the independent accountants. The Audit Committee, on an annual basis, reviews audit and non-audit
services performed by the independent accountants. All audit and non-audit services are pre-approved by the Audit Committee, which
considers, among other things, the possible effect of the performance of such services on the accountants’ independence.
All requests for services to be provided by the independent accountants, which must include a description of the services to be
rendered and the amount of corresponding fees, are submitted to the Chief Financial Officer. The CFO has the authority to authorize
services that fall within the category of services that the Audit Committee has pre-approved. If there is any question as to whether
a request for services falls within the category of services that the Audit Committee has pre-approved, the CFO will consult with
the chairman of the Audit Committee. The CFO submits requests or applications to provide services that the Audit Committee has
not pre-approved, which must include an affirmation by the CFO and the independent accountants, that the request or application
is consistent with the SEC’s rules on auditor independence, to the Audit Committee (or its chairman or any of its other members
pursuant to delegated authority) for approval.



As permitted under the Sarbanes-Oxley Act of 2002, the Audit
Committee may delegate pre-approval authority to one or more of its members. Any service pre-approved by a delegate must be reported
to the Audit Committee at the next scheduled quarterly meeting. The Audit Committee considered whether the provision of the auditors’
services, other than for the annual audit and quarterly reviews, is compatible with its independence and concluded that it is compatible.





22







PART IV



ITEM 15. Exhibits and Financial Statement Schedules.



Exhibit Index



|Exhibit |  | Description                                                                           
|------- |  | --------------------------------------------------------------------------------------
|        |  |                                                                                       
|31.1*   |  | Certification of Principal Executive Officer Pursuant to SEC Rule 13a-14(a)/15d-14(a).
|        |  |                                                                                       
|31.2*   |  | Certification of Principal Financial Officer Pursuant to SEC Rule 13a-14(a)/15d-14(a).
|        |  |                                                                                       
|*       |  | Filed herewith.                                                                       





23







SIGNATURES



Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the Registrant has duly caused this Amendment No. 1 on Form 10-K/A to be signed on its behalf by the undersigned,
thereunto duly authorized on the 30th day of April, 2015.



| | NUO THERAPEUTICS, INC.
| | ----------------------
| |                       
| | By:                   
| |                       
| |                       
| |                       



24