---



UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

FORM 10-Q

________________________



|(Mark One) |                                                                                          
|---------- | -----------------------------------------------------------------------------------------
|[x]        | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
EXCHANGE ACT OF 1934  
|           |                                                                                          
|           | For the quarterly period ended March 31, 2003                                            
|           |                                                                                          
|           | or                                                                                       
|           |                                                                                          
|[  ]       | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES
EXCHANGE ACT OF 1934
|           |                                                                                          
|           | For the transition period from    to    .                                                

Commission file number: 1-9813

GENENTECH, INC.



|Delaware
(State or other jurisdiction
of incorporation or organization) | 94-2347624
(I.R.S. Employer
Identification Number)
|----------------------------------------------------------------------- | --------------------------------------------------

1 DNA Way, South San Francisco, California  94080-4990(Address of principal executive offices and Zip Code)

(650) 225-1000(Registrant's telephone number, including area code)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.  Yes [x]  No [ ]



Indicate by check mark whether the registrant is an accelerated filer (as defined in Rule 12b-2 of the Exchange Act).  Yes [x]  No [ ]



Indicate the number of shares outstanding of each of the issuer's classes of common stock, as of the latest practicable date.



|Class                        | Number of Shares Outstanding             
|---------------------------- | -----------------------------------------
|Common Stock $0.02 par value | 510,152,095 Outstanding at April 24, 2003





---



---



GENENTECH, INC.
TABLE OF CONTENTS



|               |                                                                                                      | Page No.
|-------------- | ---------------------------------------------------------------------------------------------------- | --------
|               | PART I - FINANCIAL INFORMATION                                                                       |         
|               |                                                                                                      |         
|Item 1.        | Financial Statements                                                                                 |         
|               |                                                                                                      |         
|               | Condensed Consolidated Statements of Income -
for the three months ended March 31, 2003 and 2002     | 3       
|               |                                                                                                      |         
|               | Condensed Consolidated Statements of Cash Flows -
for the three months ended March 31, 2003 and 2002 | 4       
|               |                                                                                                      |         
|               | Condensed Consolidated Balance Sheets -
March 31, 2003 and December 31, 2002                         | 5       
|               |                                                                                                      |         
|               | Notes to Condensed Consolidated Financial Statements                                                 | 6-17    
|               |                                                                                                      |         
|               | Independent Accountants' Review Report                                                               | 18      
|               |                                                                                                      |         
|Item 2.        | Management's Discussion and Analysis of Financial Condition and Results of Operations                | 19-45   
|               |                                                                                                      |         
|Item 3.        | Quantitative and Qualitative Disclosures About Market Risk                                           | 46      
|               |                                                                                                      |         
|Item 4.        | Controls and Procedures                                                                              | 46      
|               |                                                                                                      |         
|               | PART II - OTHER INFORMATION                                                                          |         
|               |                                                                                                      |         
|Item 1.        | Legal Proceedings                                                                                    | 47      
|               |                                                                                                      |         
|Item 6.        | Exhibits and Reports on Form 8-K                                                                     | 47      
|               |                                                                                                      |         
|SIGNATURES     | 48                                                                                                  
|               |                                                                                                     
|CERTIFICATIONS | 49-50                                                                                               



In this report, "Genentech," "we," "us" and "our" refer to Genentech, Inc. "Common Stock" refers to Genentech's common stock, par value $0.02 per share and "Special Common Stock" refers to Genentech's callable putable common stock, par value $0.02 per share.



We own or have rights to various copyrights, trademarks and trade names used in our business including the following: Activase® (alteplase, recombinant) tissue-plasminogen activator; AvastinTM (bevacizumab) anti-VEGF antibody; Cathflo® Activase® (alteplase for catheter clearance); Herceptin® (trastuzumab) anti-HER2 antibody; Nutropin® (somatropin (rDNA origin) for injection) growth hormone; Nutropin AQ® and Nutropin AQ PenTM (somatropin (rDNA origin) for injection) liquid formulation growth hormone; Nutropin Depot® (somatropin (rDNA origin) for injectable suspension) encapsulated sustained-release growth hormone; Protropin® (somatrem for injection) growth hormone; Pulmozyme® (dornase alfa, recombinant) inhalation solution; TNKaseTM (tenecteplase) single-bolus thrombolytic agent; and RaptivaTM (efalizumab, formerly XanelimTM) anti-CD11a antibody.  Rituxan® (rituximab) anti-CD20 antibody is a registered trademark of IDEC Pharmaceuticals Corporation; TarcevaTM (erlotinib) is a trademark of OSI Pharmaceuticals, Inc.; and Xolair® (omalizumab) anti-IgE antibody is a trademark of Novartis AG.  This report also includes other trademarks, service marks and trade names of other companies.





Page 2

---



PART I - FINANCIAL INFORMATION

Item 1.  Financial Statements

GENENTECH, INC.CONDENSED CONSOLIDATED STATEMENTS OF INCOME



|                                                                                          | Three Months
Ended March 31,
|----------------------------------------------------------------------------------------- | ----------------------------
|                                                                                          |                             
|                                                                                          | 2003                        
|                                                                                          |                             
|Revenues:                                                                                 |                             
|Product sales (including amounts from related party:
      2003-$29,409; 2002-$21,347)    | $                           
|Royalties (including amounts from related party:
      2003-$46,887; 2002-$25,850)        |                             
|Contract revenue (including amounts from related parties:
      2003-$2,288; 2002-$3,811) |                             
|                                                                                          |                             
|Total operating revenues                                                                  |                             
|                                                                                          |                             
|Costs and expenses                                                                        |                             
|Cost of sales (including amounts for related party:
      2003-$24,829; 2002-$18,823)     |                             
|Research and development (including contract related:
      2003-$9,848; 2002-$4,450)     |                             
|Marketing, general and administrative                                                     |                             
|Collaboration profit sharing                                                              |                             
|Recurring charges related to redemption                                                   |                             
|Special charges:  Litigation-related                                                      |                             
|                                                                                          |                             
|Total costs and expenses                                                                  |                             
|                                                                                          |                             
|Operating margin                                                                          |                             
|                                                                                          |                             
|Other income, net                                                                         |                             
|                                                                                          |                             
|Income before taxes                                                                       |                             
|Income tax provision                                                                      |                             
|                                                                                          |                             
|Net income                                                                                | $                           
|                                                                                          |                             
|                                                                                          |                             
|                                                                                          |                             
|                                                                                          |                             
|Earnings per share:                                                                       |                             
|Basic                                                                                     | $                           
|                                                                                          |                             
|                                                                                          |                             
|                                                                                          |                             
|Diluted                                                                                   | $                           
|                                                                                          |                             
|                                                                                          |                             
|                                                                                          |                             
|                                                                                          |                             
|Weighted-average shares used to compute basic earnings per share                          |                             
|                                                                                          |                             
|                                                                                          |                             
|                                                                                          |                             
|Weighted-average shares used to compute diluted earnings per share                        |                             
|                                                                                          |                             
|                                                                                          |                             
|                                                                                          |                             

See Notes to Condensed Consolidated Financial Statements.



Page 3

---



GENENTECH, INC.CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS





|                                                                                       | Three Months
Ended March 31,
|-------------------------------------------------------------------------------------- | ----------------------------
|                                                                                       |                             
|                                                                                       | 2003                        
|                                                                                       |                             
|Cash flows from operating activities:                                                  |                             
|Net income                                                                             | $                           
|Adjustments to reconcile net income to net cash provided by 
    operating activities: |                             
|Depreciation and amortization                                                          |                             
|Deferred income taxes                                                                  |                             
|Gain on sales of securities available-for-sale                                         |                             
|Loss on sales of securities available-for-sale                                         |                             
|Write-down of securities available-for-sale                                            |                             
|Loss on fixed asset dispositions                                                       |                             
|Changes in assets and liabilities:                                                     |                             
|Litigation-related liability                                                           |                             
|Investments in trading securities                                                      |                             
|Receivables and other current assets                                                   |                             
|Inventories                                                                            |                             
|Accounts payable, other current liabilities and other long-term liabilities            |                             
|                                                                                       |                             
|Net cash provided by operating activities                                              |                             
|                                                                                       |                             
|Cash flows from investing activities:                                                  |                             
|Purchases of securities available-for-sale                                             |                             
|Proceeds from sales and maturities of securities available-for-sale                    |                             
|Purchases of nonmarketable equity securities                                           |                             
|Capital expenditures                                                                   |                             
|Change in other assets                                                                 |                             
|                                                                                       |                             
|Net cash used in investing activities                                                  |                             
|                                                                                       |                             
|Cash flows from financing activities:                                                  |                             
|Stock issuances                                                                        |                             
|Stock repurchases                                                                      |                             
|Repayment of short-term debt                                                           |                             
|                                                                                       |                             
|Net cash used in financing activities                                                  |                             
|                                                                                       |                             
|                                                                                       |                             
|Net decrease in cash and cash equivalents                                              |                             
|Cash and cash equivalents at beginning of period                                       |                             
|                                                                                       |                             
|Cash and cash equivalents at end of period                                             | $                           
|                                                                                       |                             
|                                                                                       |                             
|                                                                                       |                             



See Notes to Condensed Consolidated Financial Statements.



Page 4

---



GENENTECH, INC.CONDENSED CONSOLIDATED BALANCE SHEETS





|                                                                                                                      | March 31,
2003 |             | December 31,
2002
|--------------------------------------------------------------------------------------------------------------------- | -------------- | ----------- | -----------------
|                                                                                                                      |                |             |                  
|Assets:                                                                                                               |                |             |                  
|Current assets:                                                                                                       |                |             |                  
|Cash and cash equivalents                                                                                             | $              | 148,701     |                  
|Short-term investments                                                                                                |                | 936,730     |                  
|Accounts receivable - product sales, net (including amounts due from related party:
      2003-$10,034; 2002-$18,564) |                | 234,255     |                  
|Accounts receivable - royalties, net (including amounts due from related party: 
      2003-$63,079; 2002-$60,615)    |                | 132,775     |                  
|Accounts receivable - other, net (including amounts due from related parties:
      2003-$16,136; 2002-$27,715)       |                | 23,105      |                  
|Inventories                                                                                                           |                | 411,107     |                  
|Prepaid expenses and other current assets                                                                             |                | 237,289     |                  
|                                                                                                                      |                |             |                  
|Total current assets                                                                                                  |                | 2,123,962   |                  
|Long-term marketable securities and other                                                                             |                | 567,668     |                  
|Property, plant and equipment (net of accumulated depreciation:
   2003-$755,187; 2002-$727,612)                      |                | 1,114,618   |                  
|Goodwill                                                                                                              |                | 1,334,219   |                  
|Other intangible assets (net of accumulated amortization of:
   2003-$1,621,546; 2002-$1,578,884)                     |                | 886,725     |                  
|Restricted cash                                                                                                       |                | 686,600     |                  
|Other long-term assets                                                                                                |                | 114,295     |                  
|                                                                                                                      |                |             |                  
|Total assets                                                                                                          | $              | 6,828,087   |                  
|                                                                                                                      |                |             |                  
|                                                                                                                      |                |             |                  
|                                                                                                                      |                |             |                  
|                                                                                                                      |                |             |                  
|Liabilities and stockholders' equity:                                                                                 |                |             |                  
|Current liabilities:                                                                                                  |                |             |                  
|Accounts payable                                                                                                      | $              | 58,525      |                  
|Other accrued liabilities (including amounts due to related parties:
      2003-$52,179; 2002-$51,116)                |                | 585,468     |                  
|                                                                                                                      |                |             |                  
|Total current liabilities                                                                                             |                | 643,993     |                  
|Litigation-related and other long-term liabilities                                                                    |                | 790,131     |                  
|                                                                                                                      |                |             |                  
|Total liabilities                                                                                                     |                | 1,434,124   |                  
|                                                                                                                      |                |             |                  
|Commitments and contingencies                                                                                         |                |             |                  
|Stockholders' equity:                                                                                                 |                |             |                  
|Preferred stock                                                                                                       |                | -           |                  
|Common stock                                                                                                          |                | 10,209      |                  
|Additional paid-in capital                                                                                            |                | 6,632,944   |                  
|Accumulated deficit, since June 30, 1999                                                                              |                | (1,510,392) |                  
|Accumulated other comprehensive income                                                                                |                | 261,202     |                  
|                                                                                                                      |                |             |                  
|Total stockholders' equity                                                                                            |                | 5,393,963   |                  
|                                                                                                                      |                |             |                  
|Total liabilities and stockholders' equity                                                                            | $              | 6,828,087   |                  
|                                                                                                                      |                |             |                  
|                                                                                                                      |                |             |                  
|                                                                                                                      |                |             |                  

See Notes to Condensed Consolidated Financial Statements.



Page 5

---



GENENTECH, INC.NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS



|Note 1. | SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
|------- | ------------------------------------------

Basis of Presentation

In the opinion of management, the accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X.  Accordingly, they do not include all of the information and footnotes required by accounting principles generally accepted in the United States for complete financial statements.  In the opinion of management, all adjustments (consisting only of adjustments of a normal recurring nature) considered necessary for a fair presentation have been included.  Operating results for the three month period ended March 31, 2003 are not necessarily indicative of the results that may be expected for the year ending December 31, 2003.  The Condensed Consolidated Balance Sheet as of December 31, 2002 has been derived from the audited consolidated financial statements as of that date.  For further information, refer to the consolidated financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2002.

Use of Estimates



The preparation of financial statements in conformity with generally accepted accounting principles in the United States (or U.S.) requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes.  Actual results could differ from those estimates.

Recent Accounting Pronouncements

In June 2002, the Financial Accounting Standards Board (or FASB) issued FAS 146, "Accounting for Costs Associated with Exit or Disposal Activities," which addresses accounting for restructuring, discontinued operation, plant closing, or other exit or disposal activity.  FAS 146 requires companies to recognize costs associated with exit or disposal activities when they are incurred rather than at the date of a commitment to an exit or disposal plan.  FAS 146 is to be applied prospectively to exit or disposal activities initiated after December 31, 2002.  The adoption of FAS146 on January 1, 2003 did not have a significant impact on our financial position and results of operations.



In November 2002, the FASB issued Interpretation No. 45 (or FIN 45), "Guarantor's Accounting and Disclosure Requirements for Guarantees, Including Indirect Guarantees of Indebtedness of Others."  FIN 45 elaborates on the existing disclosure requirements for most guarantees, including residual value guarantees issued in conjunction with operating lease agreements.  It also clarifies that at the time a company issues a guarantee, the company must recognize an initial liability for the fair value of the obligation it assumes under that guarantee and must disclose that information in its interim and annual financial statements.  The initial recognition and measurement provisions apply on a prospective basis to guarantees issued or modified after December 31, 2002.  The disclosure requirements are effective for financial statements of interim or annual periods ending after December 15, 2002.  Our adoption of FIN 45 did not have a material impact on our results of operations and financial position.  See Note 2, "Leases and Contingencies," below for a discussion of our exposure related to our agreement with Serono S.A. and our synthetic leases and the related residual value guarantees.



In January 2003, the FASB issued Interpretation No. 46 (or FIN 46), "Consolidation of Variable Interest Entities."  FIN 46 requires a variable interest entity to be consolidated by a company if that company is subject to a majority of the risk of loss from the variable interest entity's activities or entitled to receive a majority of the entity's residual returns or both.  A variable interest entity is a corporation, partnership, trust, or any other legal structures used for business purposes that either (a) does not have equity investors with voting rights or (b) has equity investors that do not provide sufficient financial resources for the entity to support its activities.  A variable interest entity





Page 6

---





often holds financial assets, including loans or receivables, real estate or other property.  A variable interest entity  may be essentially passive or it may engage in research and development or other activities on behalf of another company.  The consolidation requirements of FIN 46 apply immediately to variable interest entities created after January 31, 2003.  The consolidation requirements apply to older entities in the first fiscal year or interim period beginning after June 15, 2003.  Certain of the disclosure requirements apply to all financial statements issued after January 31, 2003, regardless of when the variable interest entity was established.  See Note 2, "Leases and Contingencies," below for a discussion of our synthetic leases and the expanded disclosures required by FIN 46.

In December 2002, the FASB issued Statement No. 148, "Accounting for Stock-Based Compensation - Transition and Disclosure."  FAS 148 amends FAS 123 "Accounting for Stock-Based Compensation" to provide alternative methods of transition for a voluntary change to the fair value based method of accounting for stock-based employee compensation.  In addition, FAS 148 amends the disclosure requirements of FAS 123 to require more prominent disclosures in both annual and interim financial statements about the method of accounting for stock-based employee compensation and the effect of the method used on reported results.  The additional disclosure requirements of FAS 148 are effective for fiscal years ending after December 15, 2002.  We have elected to continue to follow the intrinsic value method of accounting as prescribed by Accounting Principles Board Opinion No. 25 (or APB 25), "Accounting for Stock Issued to Employees," to account for employee stock options.  Under APB 25, no compensation expense is recognized unless the exercise price of our employee stock options is less than the market price of the underlying stock on the date of grant.  We have not recorded such expenses in the periods presented because we grant options at the fair market value of the underlying stock on the date of grant.



The following information regarding net income and earnings per share prepared in accordance with FAS 123 has been determined as if we had accounted for our employee stock options and employee stock plan under the fair value method prescribed by FAS 123.  The resulting effect on net income and earnings per share pursuant to FAS 123 is not likely to be representative of the effects on net income and earnings per share pursuant to FAS 123 in future periods, due to subsequent periods including additional grants and periods of vesting.  The fair value of options was estimated at the date of grant using a Black-Scholes option valuation model with the following weighted-average assumptions for the three months ended March 31, 2003 and 2002, respectively:  risk-free interest rates of 2.8% and 4.4%; dividend yields of 0%; volatility factors of the expected market price of our Common Stock of 36.0% and 43.0%; and a weighted-average expected life of the option of five years.



The Black-Scholes option valuation model was developed for use in estimating the fair value of traded options, which have no vesting restrictions and are fully transferable.  Option valuation models require the input of highly subjective assumptions including the expected stock price volatility.  Because our employee stock options have characteristics significantly different from those of traded options, and because changes in the subjective input assumptions can materially affect the fair value estimate, in management's opinion the existing models do not provide a reliable single measure of the fair value of our employee stock options.



For purposes of disclosures pursuant to FAS 123 as amended by FAS 148, the estimated fair value of options is amortized to expense over the options' vesting period.





Page 7

---





The following table illustrates the effect on reported net income and earnings per share if we had applied the fair value recognition provisions of FAS 123 to stock-based employee compensation (in thousands, except per share amounts):





|                                                                                                                                                    | Three Months
Ended March 31,
|--------------------------------------------------------------------------------------------------------------------------------------------------- | ----------------------------
|                                                                                                                                                    |                             
|                                                                                                                                                    | 2003                        
|                                                                                                                                                    |                             
|Net income - as reported                                                                                                                            | $                           
|Deduct:  Total stock-based employee compensation expense determined
   under the fair value based method for all awards, net of related tax effects |                             
|                                                                                                                                                    |                             
|Pro forma net income                                                                                                                                | $                           
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             
|Earnings per share:                                                                                                                                 |                             
|Basic-as reported                                                                                                                                   | $                           
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             
|Basic-pro forma                                                                                                                                     | $                           
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             
|Diluted-as reported                                                                                                                                 | $                           
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             
|Diluted-pro forma                                                                                                                                   | $                           
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             
|                                                                                                                                                    |                             



Accounts Receivable Allowances



We prepare estimates for sales returns and allowances, discounts and rebates based primarily on historical trends and experience and changes in customer financial conditions.



Reclassifications



In the first quarter of 2003, we made certain classification changes in our Condensed Consolidated Statements of Income.  A new caption titled "other income, net" was added to the Condensed Consolidated Statements of Income (see below for the composition of this new caption).  The "contract and other" caption presented in prior periods was changed to "contract revenues" and the gains from the sale of biotechnology equity securities that were previously included in "contract and other" are now reflected in "other income, net."  In addition, write-downs on biotechnology equity securities previously included in "marketing, general and administrative" expenses are now also reflected in the "other income, net" caption.

The following table summarizes the components of "other income, net," for the first quarters of 2003 and 2002 (in thousands):



|                                                        |  | Three Months
Ended March 31,
|------------------------------------------------------- |  | ----------------------------
|                                                        |  |                             
|Other Income, Net                                       |  | 2003                        
|                                                        |  |                             
|Gains on sales of biotechnology equity securities       |  | $                           
|Write-downs of biotechnology debt and equity securities |  |                             
|Interest income                                         |  |                             
|Interest expense                                        |  |                             
|                                                        |  |                             
|Total other income, net                                 |  | $                           
|                                                        |  |                             
|                                                        |  |                             
|                                                        |  |                             



As part of our strategic alliance efforts, we invested in debt and equity securities of certain biotechnology companies with which we have or have had collaborative agreements.  "Other income, net" in the Condensed Consolidated Statements of Income includes realized gains and losses from the sale of certain of these biotechnology equity securities and write-downs for other-than-temporary declines in the fair value of certain of these biotechnology debt and equity securities.  In addition, "other income, net," includes interest income and interest expense, net of amounts capitalized.



Certain reclassifications of prior year amounts have been made to our Condensed Consolidated Statements of Income and our Condensed Consolidated Balance Sheets to conform with the current year presentation.





Page 8

---



|Note 2. | LEASES AND CONTINGENCIES
|------- | ------------------------



Leases



We lease various real properties under operating leases that generally require us to pay taxes, insurance, maintenance and minimum lease payments.  Some of our leases have options to renew.  Four of our operating leases are commonly referred to as synthetic leases.  A synthetic lease represents a form of off-balance sheet financing under which an unrelated third-party funds 100% of the costs of the acquisition and/or construction of the property and leases the asset to a lessee (Genentech), and at least 3% of the third-party funds represent at-risk equity.  As the lessee, our synthetic leases are treated as operating leases for accounting purposes and as financing leases for tax purposes.  (See also below regarding FIN 46).  Under our synthetic lease structures, upon termination or expiration, at our option, we must either purchase the property from the lessor at a predetermined amount that does not constitute a purchase at less than fair market value, sell the real property to a third-party, or renew the lease arrangement.  If the property is sold to a third-party at an amount less than the amount financed by the lessor, we have agreed under residual value guarantees to pay the lessor up to an agreed upon percentage of the amount financed by the lessor.



Three of our four synthetic leases were entered into with BNP Paribas Leasing Corporation (or BNP), who leases directly to us various buildings that we occupy in South San Francisco, California.  Under certain of these leases, we are required to maintain cash collateral of $56.6 million, which we have included in our Condensed Consolidated Balance Sheets as restricted cash.



The most significant of our synthetic leases relates to our manufacturing facility located in Vacaville, California. In November 2001, we completed a synthetic lease transaction for this facility, which had previously been leased to us under a predecessor synthetic lease.  This new synthetic lease is structured differently from our other synthetic leases.  As the lessee, we lease the property from an unrelated special purpose trust (owner/lessor) under an operating lease agreement for five years ending November 2006.  Third-party financing is provided in the form of a 3% at-risk equity participation from investors and 97% debt commitment.  Investors' equity contributions were equal to or greater than 3% of the fair value of the property at the lease's inception and are required to remain so for the term of the lease.  A bankruptcy-remote, special purpose corporation (SPC) was formed to fund the debt portion through the issuance of commercial paper notes.  The SPC lends the proceeds from the commercial paper to the owner/lessor, who issues promissory notes to the SPC.  The SPC loans mature in November 2006.  The SPC promissory notes are supported by a credit facility provided by financing institutions and draws are generally available under that credit facility to repay the SPC's commercial paper.  The collateral for the SPC loans includes the leased property, and an interest in the residual value guarantee provided by us.  As the lessee, at any time during the lease term, we have the option to purchase the property at an amount that does not constitute a purchase at less than fair market value.  Our off-balance sheet contingent liability under the residual value guarantees is summarized in the table below.



Under all the synthetic leases, Genentech, as the lessee, is also required to maintain certain pre-defined financial ratios and is limited to the amount of debt it can assume.  In addition, no Genentech officers or employees have any financial interest with regards to these synthetic lease arrangements or with any of the special purpose entities used in these arrangements.  In the event of a default, the maximum amount payable under the residual value guarantee would equal 100% of the amount financed by the lessor, and our obligation to purchase the leased properties or pay the related residual value guarantees could be accelerated.  We believed at the lease's inception and continue to believe that the occurrence of any event of default that could trigger our purchase obligation is remote.



Page 9

---



Future minimum lease payments under operating leases, exclusive of the residual value guarantees, executory costs and sublease income, at December 31, 2002, are as follows (in millions).  These minimum lease payments were computed based on interest rates current at that time, which are subject to fluctuations in certain market-based interest rates:



|                       | 2003 |      | 2004 |   | 2005 |  | 2006 |      | 2007 |   | Thereafter |  | Total
|---------------------- | ---- | ---- | ---- | - | ---- |  | ---- | ---- | ---- | - | ---------- |  | -----
|                       |      |      |      |   |      |  |      |      |      |   |            |  |      
|Synthetic leases       | $    | 9.6  |      | $ | 9.4  |  | $    | 8.8  |      | $ | 8.8        |  | $    
|Other operating leases |      | 4.8  |      |   | 3.3  |  |      | 3.1  |      |   | 2.6        |  |      
|                       |      |      |      |   |      |  |      |      |      |   |            |  |      
|Total                  | $    | 14.4 |      | $ | 12.7 |  | $    | 11.9 |      | $ | 11.4       |  | $    
|                       |      |      |      |   |      |  |      |      |      |   |            |  |      
|                       |      |      |      |   |      |  |      |      |      |   |            |  |      
|                       |      |      |      |   |      |  |      |      |      |   |            |  |      

The following summarizes the approximate assumed carrying values of the leased properties as of December 31, 2002, which represents the initial fair values of the facilities at the inception of the related lease, less assumed depreciation through June 30, 2003, and residual value guarantee amounts for our synthetic leases (in millions):



|                            | Approximate
Initial Fair
Value of
Leased Property |   | Estimated
Accumulated
Depreciation |  | Estimated
Carrying
Value |  | Lease
Expiration |   | Maximum
Residual
Value
Guarantee
|--------------------------- | ------------------------------------------------- | - | ---------------------------------- |  | ------------------------ |  | ---------------- | - | --------------------------------
|                            |                                                   |   |                                    |  |                          |  |                  |   |                                 
|South San Francisco Lease 1 |                                                   | $ | 56.6                               |  |                          |  |                  | $ | 21.4                            
|South San Francisco Lease 2 |                                                   |   | 152.0                              |  |                          |  |                  |   | 29.2                            
|South San Francisco Lease 3 |                                                   |   | 25.0                               |  |                          |  |                  |   | 4.9                             
|Vacaville Lease             |                                                   |   | 425.0                              |  |                          |  |                  |   | 66.0                            
|                            |                                                   |   |                                    |  |                          |  |                  |   |                                 
|Total                       |                                                   | $ | 658.6                              |  |                          |  |                  | $ | 121.5                           
|                            |                                                   |   |                                    |  |                          |  |                  |   |                                 
|                            |                                                   |   |                                    |  |                          |  |                  |   |                                 
|                            |                                                   |   |                                    |  |                          |  |                  |   |                                 

We believe that there have been no impairments in the fair value or use of the properties that we lease under synthetic leases wherein we believe that we would be required to pay amounts under any of the residual value guarantees.  We will continue to assess the fair values of the underlying properties and the use of the properties for impairment on an annual basis.



The maximum exposure to loss on our synthetic leases include (i) residual value guarantee payments as shown above, (ii) certain tax indemnifications in the event the third-parties are obligated for certain federal, state or local taxes as a result of their participation in the transaction, and (iii) indemnification for various losses, costs and expenses incurred by the third-party participants as a result of their ownership of the leased property or participation in the transaction, and as a result of the environmental condition of the property.  The additional taxes, losses and expenses as described in (ii) and (iii) are contingent upon the existence of certain conditions and, therefore, would not be quantifiable at this time.  However, we do not expect these additional taxes, losses and expenses to be material.  In the case of Lease 1, we have pledged cash collateral of $56.6 million as a source of payment for Genentech's obligation for the residual value guarantee payments and other amounts we owe under the lease.

Under the FASB's new rule, FIN 46, "Consolidation of Variable Interest Entities," it is likely that some or all of the above synthetic leasing structures qualify as variable interest entities that Genentech, as the primary beneficiary, would be required to consolidate.  We have determined that the leasing structure used in the Vacaville Lease will likely qualify as a variable interest entity under FIN 46.  Accordingly, with respect to our Vacaville Lease, we estimate that we will need to consolidate assets of $359.0 million, net of accumulated depreciation, liabilities of $412.3 million and noncontrolling interests of $12.7 million, and expect to record a charge of $39.6 million, net of tax, as a cumulative effect of an accounting change on July 1, 2003.  With regard to BNP Leases 1, 2 and 3, we are currently evaluating these leases and are seeking additional information from the lessor to determine whether or not we will need to consolidate the related assets under FIN 46 on July 1, 2003.



Contingencies



In August 2002, we entered into an agreement with Serono S.A. to market Raptiva internationally outside the United States, Japan, and certain other Asian countries.  In February 2003, we amended the agreement with Serono to expand Serono's marketing rights to include certain Asian countries other than Japan.  Development and marketing





Page 10

---





rights in the United States remain with us and our U.S. collaborator, XOMA (US) LLC, and we retain exclusive marketing rights in Japan.  Under the agreement, we and Serono may collaborate on co-developing additional indications of Raptiva and will share certain global development costs.  In addition, we have a supply agreement with Serono under which we could have a loss exposure up to a maximum of $10.0 million.



We are a party to various legal proceedings, including patent infringement litigation relating to our antibody products, and licensing and contract disputes, and other matters.

We and the City of Hope Medical Center are parties to a 1976 agreement relating to work conducted by two City of Hope employees, Arthur Riggs and Keiichi Itakura, and patents that resulted from that work, which are referred to as the "Riggs/Itakura Patents."  Since that time, Genentech has entered into license agreements with various companies to make, use and sell the products covered by the Riggs/Itakura Patents.  On August 13, 1999, the City of Hope filed a complaint against us in the Superior Court in Los Angeles County, California, alleging that we owe royalties to the City of Hope in connection with these license agreements, as well as product license agreements that involve the grant of licenses under the Riggs/Itakura Patents.  The first trial of this suit began on August 28, 2001.  On October 24, 2001, the jury hearing the lawsuit announced that it was unable to reach a verdict and on that basis the Court declared a mistrial.  City of Hope requested a retrial, and the retrial began on March 20, 2002.  On June 10, 2002, the jury voted to award the City of Hope approximately $300 million in compensatory damages.  On June 24, 2002, the jury voted to award the City of Hope an additional $200 million in punitive damages.  Such amounts were accrued as an expense in the second quarter of 2002 and were included in "litigation-related and other long-term liabilities" in the Condensed Consolidated Balance Sheets at March 31, 2003 and December 31, 2002.  Genentech filed a notice of appeal of the verdict and damages awards with the California Court of Appeal.  The appeal process is ongoing. The amount of cash, if any, to be paid in connection with the City of Hope matter will depend on the outcome of the appeal.

On June 7, 2000, Chiron Corporation filed a patent infringement suit against us in the U.S. District Court in the Eastern District of California (Sacramento), alleging that the manufacture, use, sale and offer for sale of our Herceptin antibody product infringes Chiron's U.S. Patent No. 6,054,561.  This patent was granted on April 25, 2000, and will expire on June 28, 2005, and it relates to certain antibodies that bind to breast cancer cells and/or other cells.  Chiron is seeking compensatory damages for the alleged infringement, additional damages (e.g., for willful infringement), and attorneys' fees and costs.  On April 22, 2002, the Court issued its decision ("Markman Order") construing certain aspects of the patent claims that are in dispute.  On June 25, 2002, the Court issued several decisions regarding summary judgment motions that previously had been filed by Chiron and us.  In those decisions, the Court ruled as a matter of law that Herceptin infringes claims 1 to 25 of Chiron's patent, and also ruled as a matter of law in favor of Chiron on some but not all of Genentech's defenses and counterclaims regarding the alleged invalidity and/or unenforceability of the patent.  The trial of this suit began on August 6, 2002.  Following the first phase of the trial, which related to Genentech's remaining defenses and counterclaims regarding the alleged invalidity of the patent, the jury unanimously found that claims 1 to 25 of Chiron's patent were invalid, and on that basis the Court entered judgment in favor of Genentech.  Chiron filed a notice of appeal with the U.S. Court of Appeals for the Federal Circuit, and Genentech filed a notice of cross-appeal.  The appeal process is ongoing.

On August 12, 2002, the U.S. Patent and Trademark Office (or Patent Office) declared an interference between the Chiron patent involved in the above mentioned lawsuit (U.S. Patent No. 6,054,561) and a patent application exclusively licensed by Genentech from a university relating to anti-HER2 antibodies.  An interference proceeding is declared to decide who first made a particular invention where two or more parties claim the same invention, whether the parties' claims are patentable, and consequently who is or is not entitled to a patent on the invention.  In declaring this interference, the Patent Office has determined that there is a substantial question as to whether the inventors of the Chiron patent were first to invent and are entitled to this patent.  If the Patent Office were to decide that the inventors of the university's patent application were first to invent and that their claims are patentable, a new patent would be issued to the university and the Chiron patent would be revoked.  On October 24, 2002, the Patent Office redeclared the interference to include, in addition to the above-referenced Chiron patent and university patent application, a number of patents and patent applications owned by either Chiron or Genentech, including Chiron's U.S. Patent No. 4,753,894 that is also at issue in the separate patent infringement lawsuit described below.  The interference proceeding is ongoing.



Page 11

---



On March 13, 2001, Chiron filed another patent infringement lawsuit against us in the U.S. District Court in the Eastern District of California, alleging that the manufacture, use, sale and/or offer for sale of our Herceptin antibody product infringes Chiron's U.S. Patent No. 4,753,894.  Chiron is seeking compensatory damages for the alleged infringement, additional damages, and attorneys' fees and costs.  Genentech filed a motion to dismiss this second lawsuit, which was denied.  On November 1, 2002, the parties filed a proposed stipulation to stay all proceedings in this lawsuit until (1) the interference involving U.S. Patent No. 4,753,894 is resolved or (2) two years from entry of the proposed stipulation, whichever is sooner.  On or about November 13, 2002, the Court entered the stipulation, staying the proceedings as requested by the parties.  This lawsuit is separate from and in addition to the Chiron suit mentioned above.

On July 24, 2002, Green Equity, LLC filed a shareholder derivative lawsuit in the San Francisco Superior Court against Genentech as nominal defendant and against several members of our Board of Directors, and by subsequent amendment of the lawsuit, against several current and former Genentech officers and employees (the "individual defendants").  The lawsuit is based upon the claims made by the City of Hope in the contract dispute referred to above.  The complaint alleges that the individual defendants breached the fiduciary duty they owe to Genentech by causing us to withhold royalty payments allegedly due to the City of Hope and to conceal third-party licenses that allegedly should have been disclosed to the City of Hope.  The plaintiff seeks unspecified damages, costs, and attorneys' fees.  The case was removed to federal court and is now pending in the U.S. District Court in the Northern District of California (San Francisco).  Defendants filed motions to dismiss the lawsuit, and on March 6, 2003, the Court issued an order granting in part and denying in part the motions to dismiss.  The Court dismissed the Complaint against Genentech and all the individual defendants, except for Jonathan K.C. Knowles.  The Court dismissed the Complaint against Knowles with leave to amend. On April 7, 2003, Green Equity, LLC and an additional plaintiff, Warren Jones, filed another amended Complaint against Genentech as nominal defendant and against Dr. Knowles and several other members of our Board of Directors.



We and Tanox Biosystems, Inc. (or Tanox) are parties to a July 1996 Settlement and Cross-Licensing Agreement relating to the development and manufacture of certain antibody products directed towards immunoglobin E, including Xolair and Hu-901.  On February 20, 2002, Tanox filed an amended demand in an ongoing arbitration proceeding between Genentech and Tanox that is being conducted by the American Arbitration Association in San Francisco.  In its amended demand, Tanox has claimed breach of the July 1996 Agreement, conversion, tortious interference, unjust enrichment, and unfair competition by Genentech, and requests injunctive relief as well as monetary damages "many times in excess of $100,000,000."  On March 14, 2002, Genentech denied all of Tanox's claims, and counterclaimed for breach of contract, theft of trade secrets, misappropriation, breach of confidence, interference with contract, and interference with economic expectancies by Tanox.  Genentech requested injunctive relief and monetary damages.  On October 16, 2002, Tanox announced that in a dispute between it and Novartis, an arbitration panel ruled that Tanox is not entitled to develop independently the Hu-901 antibody product.  The Novartis/Tanox panel also ruled that Tanox is entitled to receive certain know-how from Novartis.  Tanox contends in its dispute against Genentech that it is entitled to similar information from Genentech.  The effect of the October 16 ruling from the Novartis/Tanox arbitration, if any, on Tanox's claims against Genentech cannot be determined since it has not yet been resolved by the arbitrators in the Tanox/Genentech proceedings.  As a general matter, the claims are divided into two categories: (1) compensation for lost rights under agreements with Genentech and Novartis, and (2) additional royalties on future sales.  The arbitration began on January 13, 2003 and is ongoing.  Tanox closed its case on January 30, 2003 and Genentech closed its case on March 30, 2003.  A decision in the arbitration is expected on or before June 13, 2003.  The outcome of this matter cannot be determined at this time.

On April 11, 2003, MedImmune, Inc. filed a lawsuit against Genentech, City of Hope National Medical Center, and Celltech R & D Ltd. in the U.S. District Court for the Central District of California (Los Angeles).  The lawsuit relates to U.S. Patent No. 6,331,415 ("the '415 patent") that is co-owned by Genentech and City of Hope and under which MedImmune and other companies have been licensed and are paying royalties to Genentech.  The lawsuit includes claims for violation of antitrust, patent, and unfair competition laws.  MedImmune is seeking to have the '415 patent declared invalid and/or unenforceable, a determination that MedImmune does not owe royalties under the '415 patent on sales of its Synagis® antibody product, an injunction to prevent Genentech from enforcing the '415 patent, an award of actual and exemplary damages, and other relief.  Genentech intends to vigorously defend itself against all of the allegations and claims in this lawsuit.  An estimate of any potential loss or range of loss cannot be made at this time.



Page 12

---



In the first quarter of 2003, we recorded $13.3 million for accrued interest and costs related to the surety bond we obtained in the third quarter of 2002 for the City of Hope trial judgment.  In 2002, we recognized $543.9 million of litigation-related special charges.  These special charges were comprised of the City of Hope litigation judgment in the second quarter of 2002, accrued interest and costs related to obtaining a surety bond, and certain other litigation-related matters.  In conjunction with the City of Hope judgment, in the third quarter of 2002 we posted a $600.0 million surety bond and as part of this arrangement, we were required to pledge $630.0 million in cash and investments to secure the bond.  The $630.0 million cash and investments were classified as restricted cash on our Condensed Consolidated Balance Sheets at March 31, 2003 and December 31, 2002.  In addition, we accrued $2.4 million of royalty expenses related to the City of Hope judgment in the first quarter of 2003, which was reflected in marketing, general and administrative expenses.  We expect that we will continue to incur interest charges on the judgment and service fees on the surety bond each quarter through the process of appealing the City of Hope trial results.  These special charges represent our best estimate of the costs for the current resolution of these matters and are included in litigation-related and other long-term liabilities in the Condensed Consolidated Balance Sheets at March 31, 2003 and December 31, 2002.  We developed this estimate in consultation with outside counsel handling our defense in these matters and it is based upon the facts and circumstances of these matters known to us at that time.  The amount of our liability for certain of these matters could exceed or be less than the amount of our current estimate, depending on the outcome of these matters.  The amount of cash, if any, paid in connection with the City of Hope matter will depend on the outcome of the appeal.



|Note 3. | RELATIONSHIP WITH ROCHE
|------- | -----------------------



Redemption of Our Special Common Stock

On June 30, 1999, we redeemed all of our outstanding Special Common Stock held by stockholders other than Roche Holdings, Inc. (or Roche) with funds deposited by Roche for that purpose.  This event, referred to as the "Redemption," caused Roche to own 100% of our common stock on that date.  The Redemption was reflected as a purchase of a business which under U.S. generally accepted accounting principles, required push-down accounting to reflect in our financial statements the amount paid for our stock in excess of our net book value plus Roche's transaction costs at June 30, 1999.  See Note 4, "Goodwill and Other Intangible Assets," for the amortization of our other intangible assets.

Roche's Ability to Maintain Its Percentage Ownership Interest in Our Stock

We expect from time to time to issue additional shares of common stock in connection with our stock option and stock purchase plans, and we may issue additional shares for other purposes.  Our affiliation agreement with Roche provides, among other things, that we will establish a stock repurchase program designed to maintain Roche's percentage ownership interest in our common stock.  The affiliation agreement provides that we will repurchase a sufficient number of shares pursuant to this program such that, with respect to any issuance of common stock by Genentech in the future, the percentage of Genentech common stock owned by Roche immediately after such issuance will be no lower than Roche's lowest percentage ownership of Genentech common stock at any time after the offering of common stock occurring in July 1999 and prior to the time of such issuance, except that Genentech may issue shares up to an amount that would cause Roche's lowest percentage ownership to be no more than 2% below the "Minimum Percentage."  The Minimum Percentage equals the lowest number of shares of Genentech common stock owned by Roche since the July 1999 offering (to be adjusted in the future for dispositions of shares of Genentech common stock by Roche as well as for stock splits or stock combinations) divided by 509,194,352 (to be adjusted in the future for stock splits or stock combinations), which is the number of shares of Genentech common stock outstanding at the time of the July 1999 offering, as adjusted for the two-for-one splits of Genentech common stock in November 1999 and October 2000.  As long as Roche's percentage ownership is greater than 50%, prior to issuing any shares, the affiliation agreement provides that we will repurchase a sufficient number of shares of our common stock such that, immediately after our issuance of shares, Roche's percentage ownership will be greater than 50%.  The affiliation agreement also provides that, upon Roche's request, we will repurchase shares of our common stock to increase Roche's ownership to the Minimum Percentage.  In addition, Roche will have a continuing option to buy stock from us at prevailing market prices to maintain its percentage ownership interest.  On March 31, 2003, Roche's percentage ownership of our common stock was 60.1%.



Page 13

---





|Note 4. | GOODWILL AND OTHER INTANGIBLE ASSETS
|------- | ------------------------------------

Goodwill represents the difference between the purchase price and the fair value of the net assets when accounted for by the purchase method of accounting arising from the Redemption (see above Note 3, "Relationship With Roche").  The carrying amount of goodwill at March 31, 2003 and December 31, 2002 was $1,334.2 million.  We performed an impairment test of goodwill upon adoption of FAS 142 on January 1, 2002, and an impairment test on September 30, 2002, and found no impairment.  We will continue to monitor the carrying value of our goodwill through impairment tests performed at least annually.

The components of our acquisition-related intangible assets arising from the Redemption and push-down accounting (see above Note 3, "Relationship With Roche"), patents and other intangible assets at March 31, 2003 and December 31, 2002, are as follows (in millions):



|                              | March 31, 2003        |         | December 31, 2002       
|----------------------------- | --------------------- | ------- | ------------------------
|                              |                       |         |                         
|                              | Gross
Carrying
Amount |         | Accumulated
Amortization
|                              |                       |         |                         
|Developed product technology  | $                     | 1,194.1 |                         
|Core technology               |                       | 443.5   |                         
|Developed license technology  |                       | 467.5   |                         
|Tradenames                    |                       | 144.0   |                         
|Key distributor relationships |                       | 80.0    |                         
|Patents                       |                       | 102.2   |                         
|Other intangible assets       |                       | 77.0    |                         
|                              |                       |         |                         
|Total                         | $                     | 2,508.3 |                         
|                              |                       |         |                         
|                              |                       |         |                         
|                              |                       |         |                         

Amortization expense of our other intangible assets was $43.0 million in the first quarter of 2003 and $42.4 million in the first quarter of 2002.

The expected future annual amortization expense of our other intangible assets is as follows (in millions):





|For the Year Ending December  31,         |  | Amortization
Expense
|----------------------------------------- |  | --------------------
|                                          |  |                     
|2003 (remaining nine months)              |  | $                   
|2004                                      |  |                     
|2005                                      |  |                     
|2006                                      |  |                     
|2007                                      |  |                     
|2008                                      |  |                     
|Thereafter                                |  |                     
|                                          |  |                     
|Total expected future annual amortization |  | $                   
|                                          |  |                     
|                                          |  |                     
|                                          |  |                     



|Note 5. | DERIVATIVE FINANCIAL INSTRUMENTS
|------- | --------------------------------



We record gains and losses on derivatives related to our equity hedging instruments in "other income, net" in the Condensed Consolidated Statements of Income.  We had no such gains or losses in the first quarters of 2003 or 2002.



At March 31, 2003, net losses on derivative instruments expected to be reclassified from accumulated other comprehensive income to earnings during the next twelve months are $3.3 million due to the recognition of premiums related to maturing foreign currency exchange options.





Page 14

---





Derivative Activity in Accumulated Other Comprehensive Income

The following table summarizes activity in other comprehensive income (or OCI) related to derivatives, net of taxes, held during the first quarters of 2003 and 2002 (in thousands):



|                                                   | Three Months
Ended March 31,
|-------------------------------------------------- | ----------------------------
|                                                   |                             
|                                                   | 2003                        
|                                                   |                             
|Changes in fair value of derivatives               | $                           
|Losses reclassified from OCI to income             |                             
|                                                   |                             
|Change in unrealized gains (losses) on derivatives | $                           
|                                                   |                             
|                                                   |                             
|                                                   |                             

|Note 6. | COMPREHENSIVE INCOME
|------- | --------------------



Comprehensive income is comprised of net income and OCI.  OCI includes certain changes in stockholders' equity that are excluded from net income.  OCI includes changes in fair value of derivatives designated as and effective as hedges and unrealized gains and losses on our available-for-sale securities.  The following table summarizes the components of total comprehensive income, net of taxes, during the first quarters of 2003 and 2002 (in thousands):





|                                                               | Three Months
Ended March 31,
|-------------------------------------------------------------- | ----------------------------
|                                                               |                             
|                                                               | 2003                        
|                                                               |                             
|Net income                                                     | $                           
|Change in unrealized (losses) on securities available-for-sale |                             
|Change in unrealized gains (losses) on derivatives             |                             
|                                                               |                             
|Comprehensive income                                           | $                           
|                                                               |                             
|                                                               |                             
|                                                               |                             



The components of accumulated other comprehensive income, net of taxes, are as follows (in thousands):



|                                                  | March 31, 2003 |   | December 31, 2002
|------------------------------------------------- | -------------- | - | -----------------
|                                                  |                |   |                  
|Unrealized gains on securities available-for-sale |                | $ | 256,509          
|Unrealized gains on derivatives                   |                |   | 4,693            
|                                                  |                |   |                  
|Accumulated other comprehensive income            |                | $ | 261,202          
|                                                  |                |   |                  
|                                                  |                |   |                  
|                                                  |                |   |                  

|Note 7. | EARNINGS PER SHARE
|------- | ------------------

The following is a reconciliation of the denominator used in basic and diluted earnings per share (EPS) computations for the quarters ended March 31, 2003 and 2002 (in thousands):



|                                                                                             | Three Months
Ended March 31,
|-------------------------------------------------------------------------------------------- | ----------------------------
|                                                                                             |                             
|                                                                                             | 2003                        
|                                                                                             |                             
|Numerator:                                                                                   |                             
|Net income                                                                                   | $                           
|                                                                                             |                             
|                                                                                             |                             
|                                                                                             |                             
|Denominator:                                                                                 |                             
|Weighted-average shares outstanding used for basic earnings per share                        |                             
|Effect of dilutive securities:                                                               |                             
|Stock options                                                                                |                             
|                                                                                             |                             
|Weighted-average shares and dilutive stock options used for diluted earnings
      per share |                             
|                                                                                             |                             
|                                                                                             |                             
|                                                                                             |                             



Options to purchase 24,110,816 shares of common stock between $35.87 and $95.66 per share were outstanding in the first quarter of 2003, and options to purchase 9,542,574 shares of common stock between $50.55



Page 15

---





and $95.66 per share were outstanding in the first quarter of 2002.  These options were excluded from the computation of diluted EPS because such options were anti-dilutive in the respective periods presented.

|Note 8. | INVENTORIES
|------- | -----------



In anticipation of the launch of Xolair, we produced in prior years approximately $76.6 million of inventory, of which $45.5 million has been paid for by our collaborator, Novartis Pharmaceuticals Corporation, or are covered by inventory reserves.  In anticipation of the launch of Raptiva, we produced approximately $11.5 million of inventory, of which $6.9 million has been covered by inventory reserves.  The Xolair and Raptiva inventories are included in work in process.  Due to the launch delays of Xolair and Raptiva, we continually assess the realizability of these inventories based on expected U.S. Food and Drug Administration approval dates, forecasted sales, and product expiration.  Inventories at March 31, 2003 and December 31, 2002 are summarized below (in thousands):





|                           | March 31, 2003 |   | December 31, 2002
|-------------------------- | -------------- | - | -----------------
|                           |                |   |                  
|Raw materials and supplies |                | $ | 31,733           
|Work in process            |                |   | 337,943          
|Finished goods             |                |   | 41,431           
|                           |                |   |                  
|Total                      |                | $ | 411,107          
|                           |                |   |                  
|                           |                |   |                  
|                           |                |   |                  



|Note 9. | CAPITAL STOCK
|------- | -------------

Stock Repurchase Program



Under the stock repurchase program approved by our Board of Directors on October 31, 2001, as extended on August 15, 2002, we are authorized to repurchase up to $1 billion of our common stock through the period ending June 30, 2003.  Purchases may be made in the open market or in privately negotiated transactions from time to time at management's discretion.  We may also engage in transactions in other Genentech securities in conjunction with the repurchase program, including derivative securities.  Due to the extension of the stock repurchase program, a new 10b5-1 trading plan was entered into on November 13, 2002, to repurchase shares in the open market during those periods each quarter when trading in our stock is restricted under our insider trading policy.  This plan covers 2.5 million shares.  Under the stock repurchase program, we repurchased approximately 3.2 million shares of our common stock in the first quarter of 2003 at a cost of approximately $113.2 million.  Of those shares repurchased, approximately 1.2 million were repurchased under our current 10b5-1 insider trading plan.  In the first quarter of 2002, we repurchased 3.7 million shares of our common stock at a cost of approximately $179.9 million.  Of those shares repurchased, approximately 0.3 million were repurchased under our prior 10b5-1 insider trading plan.  Under the stock repurchase program to date, we repurchased approximately 21.5 million shares of our common stock at a cost of approximately $811.6 million during the period from November 1, 2001 through March 31, 2003.



The par value method of accounting is used for common stock repurchases.  The excess of the cost of shares acquired over the par value is allocated to additional paid-in capital with the amounts in excess of the estimated original sales price charged to accumulated deficit.



|Note 10. | TAXES
|-------- | -----

The tax provision of $56.0 million in the first quarter of 2003 increased over the tax provision of $33.6 million in the first quarter of 2002 primarily due to increased pretax income and decreased tax credits, partially offset by a $17.0 million favorable change in estimate of prior years items.



The effective tax rate was 27% in the first quarter of 2003 compared to 26% in the first quarter of 2002.  The increase reflects a decrease in tax credits, partially offset by a favorable change in estimate of prior years items.



|Note 11. | SUBSEQUENT EVENTS
|-------- | -----------------



Under our stock repurchase program approved by our Board of Directors on October 31, 2001 and extended on August 15, 2002, we have repurchased approximately 1.0 million shares of our common stock at a cost of





Page 16

---





approximately $34.6 million during the period from April 1, 2003 through April 25, 2003.  Of these shares, 0.3 million shares were repurchased at a cost of approximately $12.0 million under our current 10b5-1 insider trading plan.  For more information on our stock repurchase program, see the "Capital Stock" note above.



On April 11, 2003, MedImmune, Inc. filed a lawsuit against Genentech, City of Hope National Medical Center, and Celltech R & D Ltd. in the U.S. District Court for the Central District of California (Los Angeles).  The lawsuit relates to U.S. Patent No. 6,331,415 ("the '415 patent") that is co-owned by Genentech and City of Hope and under which MedImmune and other companies have been licensed and are paying royalties to Genentech.  The lawsuit includes claims for violation of antitrust, patent, and unfair competition laws.  MedImmune is seeking to have the '415 patent declared invalid and/or unenforceable, a determination that MedImmune does not owe royalties under the '415 patent on sales of its Synagis® antibody product, an injunction to prevent Genentech from enforcing the '415 patent, an award of actual and exemplary damages, and other relief.  Genentech intends to vigorously defend itself against all of the allegations and claims in this lawsuit.  An estimate of any potential loss or range of loss cannot be made at this time.





Page 17

---





INDEPENDENT ACCOUNTANTS' REVIEW REPORT



The Board of Directors and Stockholders of Genentech, Inc.

We have reviewed the accompanying condensed consolidated balance sheet of Genentech, Inc. as of March 31, 2003, and the related condensed consolidated statements of income and cash flows for each of the three-month periods ended March 31, 2003 and 2002.  These financial statements are the responsibility of Genentech's management.

We conducted our reviews in accordance with standards established by the American Institute of Certified Public Accountants.  A review of interim financial information consists principally of applying analytical procedures to financial data, and making inquiries of persons responsible for financial and accounting matters.  It is substantially less in scope than an audit conducted in accordance with auditing standards generally accepted in the United States, which will be performed for the full year with the objective of expressing an opinion regarding the financial statements taken as a whole.  Accordingly, we do not express such an opinion.

Based on our reviews, we are not aware of any material modifications that should be made to the accompanying condensed consolidated financial statements referred to above for them to be in conformity with accounting principles generally accepted in the United States.

We have previously audited, in accordance with auditing standards generally accepted in the United States, the consolidated balance sheet of Genentech, Inc. as of December 31, 2002, and the related consolidated statements of operations, stockholders' equity, and cash flows for the year then ended (not presented herein) and in our report dated January 14, 2003 (except for the note titled Subsequent Event, as to which the date is February 12, 2003), we expressed an unqualified opinion on those consolidated financial statements.  In our opinion, the information set forth in the accompanying condensed consolidated balance sheet as of December 31, 2002, is fairly stated, in all material respects, in relation to the consolidated balance sheet from which it has been derived.





| | /s/ERNST & YOUNG LLP
| | --------------------



Palo Alto, California
April 8, 2003, except
for Note 11, as to which
the date is April 25, 2003



Page 18

---



Item 2.  Management's Discussion and Analysis of Financial Condition and Results of Operations



GENENTECH, INC.
FINANCIAL REVIEW

OVERVIEW

Genentech is a leading biotechnology company using human genetic information to discover, develop, manufacture and commercialize biotherapeutics for significant unmet medical needs.  We manufacture and commercialize 10 biotechnology products listed below and license several additional products to other companies.

- Herceptin (trastuzumab) antibody for the treatment of certain patients with metastatic breast cancer whose tumors overexpress the Human Epidermal growth factor Receptor type 2 (or HER2) protein;



- Rituxan (rituximab) antibody which we market together with IDEC Pharmaceuticals Corporation (or IDEC) for the treatment of patients with relapsed or refractory low-grade or follicular, CD20-positive B-cell non-Hodgkin's lymphoma;



- TNKase (tenecteplase) single-bolus thrombolytic agent for the treatment of acute myocardial infarction (heart attack);



- Activase (alteplase, recombinant) tissue plasminogen activator (or t-PA) for the treatment of acute myocardial infarction, acute ischemic stroke (brain attack) within three hours of the onset of symptoms and acute massive pulmonary embolism (blood clots in the lungs);



- Cathflo Activase (alteplase, recombinant) tissue plasminogen activator approved for the restoration of function to central venous access devices that have become occluded due to a blood clot;



- Nutropin Depot [somatropin (rDNA origin) for injectable suspension] long-acting growth hormone for the treatment of growth failure associated with pediatric growth hormone deficiency;



- Nutropin AQ [somatropin (rDNA origin) for injection] liquid formulation growth hormone for the same indications as Nutropin;



- Nutropin [somatropin (rDNA origin) for injection] human growth hormone for the treatment of growth hormone deficiency in children and adults, growth failure associated with chronic renal insufficiency prior to kidney transplantation and short stature associated with Turner syndrome;



- Protropin (somatrem for injection) growth hormone for the treatment of inadequate endogenous growth hormone secretion, or growth hormone deficiency, in children (manufacture of Protropin has been discontinued but sales will continue for up to one year until inventory is depleted); and



- Pulmozyme (dornase alfa, recombinant) inhalation solution for the treatment of cystic fibrosis.



We receive royalties on sales of rituximab, Pulmozyme and Herceptin outside of the United States and on sales of human growth hormone, Rituxan, Pulmozyme, Activase and TNKase in Canada from F. Hoffmann-La Roche (or Hoffmann-La Roche).  We receive royalties from third parties on sales of growth hormone products within the United States and outside of the United States, on sales of t-PA outside of the United States and Canada, and on sales of tenecteplase outside of the United States, Canada and Japan.  We also receive worldwide royalties on additional licensed products that are marketed by other companies.





Page 19

---





Redemption of Our Special Common Stock

On June 30, 1999, we redeemed all of our outstanding Special Common Stock held by stockholders other than Roche Holdings, Inc. (or Roche) at a price of $20.63 per share in cash with funds deposited by Roche for that purpose.  We refer to this event as the "Redemption."  As a result, on that date, Roche's percentage ownership of our outstanding Common Stock increased from 65% to 100%.  Consequently, under accounting principles generally accepted in the United States, we were required to use push-down accounting to reflect in our financial statements the amounts paid for our stock in excess of our net book value.  Push-down accounting required us to record $1,685.7 million of goodwill and $1,499.0 million of other intangible assets onto our balance sheet on June 30, 1999.  See also below in the "Recurring Charges Related to Redemption" section of Results of Operations and Note 3, "Relationship With Roche -- Redemption of Our Special Common Stock," in the Notes to Condensed Consolidated Financial Statements.

Roche's Ability to Maintain Its Percentage Ownership Interest in Our Stock

We expect from time to time to issue additional shares of common stock in connection with our stock option and stock purchase plans, and we may issue additional shares for other purposes.  Our affiliation agreement with Roche provides, among other things, that we establish a stock repurchase program designed to maintain Roche's percentage ownership interest in our common stock.  The affiliation agreement provides that we will repurchase a sufficient number of shares pursuant to this program such that, with respect to any issuance of common stock by Genentech in the future, the percentage of Genentech common stock owned by Roche immediately after such issuance will be no lower than Roche's lowest percentage ownership of Genentech common stock at any time after the offering of common stock occurring in July 1999 and prior to the time of such issuance, except that Genentech may issue shares up to an amount that would cause Roche's lowest percentage ownership to be no more than 2% below the "Minimum Percentage."  The Minimum Percentage equals the lowest number of shares of Genentech common stock owned by Roche since the July 1999 offering (to be adjusted in the future for dispositions of shares of Genentech common stock by Roche as well as for stock splits or stock combinations) divided by 509,194,352 (to be adjusted in the future for stock splits or stock combinations), which is the number of shares of Genentech common stock outstanding at the time of the July 1999 offering, as adjusted for the two-for-one splits of Genentech common stock in November 1999 and October 2000.  As long as Roche's percentage ownership is greater than 50%, prior to issuing any shares, the affiliation agreement provides that we will repurchase a sufficient number of shares of our common stock such that, immediately after our issuance of shares, Roche's percentage ownership will be greater than 50%.  The affiliation agreement also provides that, upon Roche's request, we will repurchase shares of our common stock to increase Roche's ownership to the Minimum Percentage.  In addition, Roche will have a continuing option to buy stock from us at prevailing market prices to maintain its percentage ownership interest.  On March 31, 2003, Roche's percentage ownership of our common stock was 60.1%.

Reclassifications



In the first quarter of 2003, we made certain classification changes in our Condensed Consolidated Statements of Income.  A new caption titled "other income, net" was added to the Condensed Consolidated Statements of Income (see below in "Results of Operations -- Other Income, Net" for the composition of this new caption).  The "contract and other" caption presented in prior periods was changed to "contract revenues" and the gains from the sale of biotechnology equity securities that were previously included in "contract and other" are now reflected in "other income, net."  In addition, write-downs on biotechnology equity securities previously included in "marketing, general and administrative" expenses are now also reflected in the "other income, net," caption.

Certain reclassifications of prior year amounts have been made to our Condensed Consolidated Statements of Income and our Condensed Consolidated Balance Sheets to conform with the current year presentation.





Page 20

---





Available Information



Our quarterly reports on Form 10-Q, annual reports on Form 10-K and our other filings with the Securities and Exchange Commission, and any amendments to such filings, can be found on our website at http://www.gene.com or can be obtained by contacting our Investor Relations Department at (650) 225-1599 or by sending an e-mail message to investor.relations@gene.com.

CRITICAL ACCOUNTING POLICIES

The preparation of our financial statements in conformity with accounting principles generally accepted in the United States requires management to make judgments, assumptions and estimates that affect the amounts reported in our financial statements and accompanying notes.  Actual results could differ materially from those estimates.  The following are critical accounting policies important to our financial condition and results of operations presented in the financial statements and require management to make judgments, assumptions and estimates that are inherently uncertain:

Operating Leases



We lease various real properties under operating leases that generally require us to pay taxes, insurance, maintenance and minimum lease payments.  Four of our operating leases are commonly referred to as "synthetic leases."  A synthetic lease is a form of off-balance sheet financing under which an unrelated third-party funds 100% of the costs for the acquisition and/or construction of the property and leases the asset to a lessee (Genentech), and at least 3% of the third-party funds represent at-risk equity.  As the lessee, our synthetic leases are treated as operating leases for accounting purposes and financing leases for tax purposes.  We periodically review the fair values of the properties we lease in order to determine potential accounting ramifications.  Adverse changes in the fair value of the properties we lease and changes in the equity participation of third-parties could affect the classification of these leases from operating to financing for accounting purposes.  In addition, our adoption of the Financial Accounting Standards Board's Interpretation No. 46, "Consolidation of Variable Interest Entities," and the consolidation of some or all of our synthetic leases effective July 1, 2003, may have a material impact on our financial condition and results of operations.  See the "Recent Accounting Pronouncements " section below for a more complete discussion of our synthetic leases.

Legal Contingencies



We are currently involved in certain legal proceedings as discussed in Note 2, "Leases and Contingencies" in the Notes to Condensed Consolidated Financial Statements of Part I, Item 1 of this Form 10-Q.  As of March 31, 2003, we have accrued our estimate of the costs for the current resolution of these matters.  We developed these estimates in consultation with outside counsel handling our defense in these matters and it is based upon the facts and circumstances of these matters known to us at that time.  The amount of our liability for certain of these matters could exceed or be less than the amount of our current estimates, depending on the outcome of these matters.



Revenue Recognition

- We recognize revenue from product sales when there is persuasive evidence that an arrangement exists, delivery has occurred, the price is fixed and determinable, and collectibility is reasonably assured.  Allowances are established for estimated uncollectible amounts, product returns and discounts.



- We receive royalties from licensees, which are based on third-party sales of licensed products or technologies.  Royalties are recorded as earned in accordance with the contract terms when third-party results can be reliably measured and collectibility is reasonably assured.  Royalty estimates are made in advance of amounts collected using historical and forecasted trends.



- Contract revenue for research and development (or R&D) is recorded as earned based on the performance requirements of the contract.  Non-refundable license fees for which no further performance obligations





Page 21

---





exist, and there is no continuing involvement by Genentech, are recognized on the earlier of when the payments are received or when collection is assured.



Revenue from non-refundable upfront license fees and certain guaranteed payments where we continue involvement through development collaboration or an obligation to supply product is recognized ratably over the development period when, at the execution of the agreement, the development period involves significant risk due to the incomplete stage of the product's development, or over the period of the manufacturing obligation, when, at the execution of the agreement, the product is approved for marketing, or nearly approvable, and development risk has been substantially eliminated.  Deferred revenues related to manufacturing obligations are recognized on a straight-line basis over the longer of the contractual term of the manufacturing obligation or the expected period over which we will supply the product.



Revenue associated with performance milestones is recognized based upon the achievement of the milestones, as defined in the respective agreements.  Revenue under R&D cost reimbursement contracts is recognized as the related costs are incurred.



Advance payments received in excess of amounts earned are classified as deferred revenue until earned.



Research and Development Expenses



Research and development (or R&D) expenses include related salaries and benefits, clinical trial and related clinical manufacturing costs, contract and other outside service fees, and facilities and overhead costs.  R&D expenses consist of independent R&D costs and costs associated with collaborative R&D and in-licensing arrangements.  In addition, we fund R&D at other companies and research institutions under agreements, which we can generally terminate at will.  R&D expenses also include activities such as product registries and investigator sponsored trials.  R&D costs, including some upfront fees and milestones paid to collaborators, are expensed as incurred.  The timing of upfront fees and milestone payments in the future may cause variability in our future R&D expenses.



Income Taxes



Income tax expense is based on pretax financial accounting income under the liability method. Deferred tax assets and liabilities are determined based on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to reverse.  Significant estimates are required in determining our provisions for income taxes.  Various internal and external factors may have favorable or unfavorable effects on our future effective tax rate.  These factors include, but are not limited to, changes in tax laws, regulations and/or rates, changing interpretations of existing tax laws or regulations, future levels of R&D spending, future levels of capital expenditures, and changes in overall levels of pretax earnings.  We believe that our reserves for these uncertainties are adequate.



Accounts Receivable Allowances



We prepare estimates for sales returns and allowances, discounts and rebates based primarily on historical trends and experience and changes in customer financial conditions. If actual future results vary, we may need to adjust our estimates, which could have an impact on earnings in the period of the adjustment.



Inventories

Our inventories are stated at the lower of cost or market. Cost is determined using a weighted-average approach, which approximates the first-in first-out method.  If inventory costs exceed expected market value due to obsolescence or unmarketability, reserves are recorded for the difference between the cost and the market value.  These reserves are determined based on significant estimates.

Inventories consist of currently marketed products and product candidates awaiting regulatory approval, which are capitalized based on management's judgment of probable near term commercialization.  We would be





Page 22

---





required to expense previously capitalized costs related to pre-approval inventory upon a change in such judgment, due to, among other potential factors, a denial or delay of approval by the necessary regulatory bodies.  At March 31, 2003, inventories related to Xolair and Raptiva products, which have not yet received regulatory approval, were $35.7 million, net of related reserves and amounts paid by our collaborator.



Marketable Equity Securities and Other



Marketable equity securities and other debt securities are carried at fair value with unrealized gains and losses on securities classified as "available-for-sale" included in accumulated other comprehensive income in stockholders' equity.  If the fair value of a security has declined below its carrying value for each trading day for six consecutive months or if the decline is due to a significant adverse event, the impairment is considered to be other-than-temporary.  An other-than-temporary decline in fair value of a debt or equity security of a biotechnology company is written down to its estimated fair value with a charge to "other income, net."  Other-than-temporary declines in fair value of all other short-term or long-term marketable securities are charged against interest income, included in "other income, net."  Some of the factors we consider in determining whether a significant adverse event has occurred with an issuer include, among other things, unfavorable clinical trial results and the prospect for new products, a denial of a product approval by a regulatory body, the termination of a major collaborative partnership and the liquidity position and financing activities of the issuer.  The determination of whether a decline in fair value is other-than-temporary requires significant judgment, and can have a material impact on our financial results.



Nonmarketable Equity Securities



Nonmarketable equity securities are carried at cost.  We periodically monitor the fair value of such securities by reviewing the liquidity position and financing activities of the respective issuers to determine if impairment write-downs are necessary.  In the event that impairment write-downs are recorded and subsequently recovered upon the sale of the related security, our financial results will be favorably impacted.  We record impairments in "other income, net."



RESULTS OF OPERATIONS(dollars in millions, except per share amounts)

This discussion of our Results of Operations contains forward-looking statements regarding the costs related to the completion of in-process projects.  Actual results could differ materially.  For a discussion of the risks and uncertainties associated with the costs related to the completion of in-process projects see "The Successful Development of Biotherapeutics is Highly Uncertain," "We May Be Unable to Obtain or Maintain Regulatory Approvals for Our Products," "Difficulties or Delays in Product Manufacturing Could Harm Our Business," "Protecting Our Proprietary Rights Is Difficult and Costly" and "We May Be Unable to Retain Skilled Personnel and Maintain Key Relationships" sections of "Forward-Looking Information and Cautionary Factors That May Affect Future Results" below.



|                         |  | Three Months
Ended March 31, |       |     
|------------------------ |  | ---------------------------- | ----- | ----
|                         |  |                              |       |     
|                         |  | 2003                         |       | 2002
|                         |  |                              |       |     
|Total operating revenues |  | $                            | 749.7 |     

Total operating revenues increased 32% in the first quarter of 2003 from the comparable period in 2002.  The increase was due to higher product sales, royalty income and contract revenues.  These increases are further discussed below.



Page 23

---





|                    |  | Three Months
Ended March 31, |       |     
|------------------- |  | ---------------------------- | ----- | ----
|                    |  |                              |       |     
|Product Sales       |  | 2003                         |       | 2002
|                    |  |                              |       |     
|Rituxan             |  | $                            | 341.0 |     
|Herceptin           |  |                              | 93.7  |     
|Growth Hormone      |  |                              | 76.7  |     
|Thrombolytics       |  |                              | 47.5  |     
|Pulmozyme           |  |                              | 39.6  |     
|                    |  |                              |       |     
|Total product sales |  | $                            | 598.5 |     
|                    |  |                              |       |     
|                    |  |                              |       |     
|                    |  |                              |       |     

Total Product Sales

Total net product sales increased 26% in the first quarter of 2003 from the comparable period in 2002 due to higher sales of all products.  Increased sales volume accounted for a 20% increase, or $96.1 million, in the first quarter of 2003, and was primarily attributable to Rituxan, Pulmozyme, growth hormone and Herceptin products.  Higher sales prices accounted for the remainder of the increase in the first quarter of 2003 and were primarily attributable to price increases with respect to our Rituxan, growth hormone, Pulmozyme and Herceptin products.

Rituxan



Net sales of Rituxan increased 38% in the first quarter of 2003 from the comparable period in 2002. This increase was primarily due to increased use of the product for the treatment of B-cell non-Hodgkin's lymphoma in indolent and aggressive non-Hodgkin's lymphoma (NHL), as well as chronic lymphocytic leukemia (CLL), used in both monotherapy and combination therapy settings. The current approved label indication is for relapsed, indolent or low grade NHL.  The increase was also due to, a lesser extent, a price increase.  Net sales of Rituxan decreased 2% from the fourth quarter of 2002.  While wholesaler inventories of Rituxan were within our typical ranges at the end of both quarters, they were at the higher end of the typical range at the end of December 2002 and at the lower end of the typical range by the end of March 2003.  Also, there were fewer billing days in the first quarter of 2003 than in the previous quarter.  During the first quarter of 2003, the National Comprehensive Cancer Network (or NCCN) issued guidelines that included the use of Rituxan in the relapsed aggressive NHL setting.



Herceptin



Net sales of Herceptin increased 8% in the first quarter of 2003 from the comparable period in 2002.  The increase was due to penetration in first-line use in the metastatic breast cancer market and a longer average treatment duration.  The increase was also due to, a lesser extent, a price increase.  The increase was partly offset by a $9.5 million decrease in ex-U.S. sales as there were no Herceptin sales to Hoffmann-La Roche this quarter.  Net Herceptin sales decreased 12% from the prior quarter primarily due to no Herceptin sales to Hoffmann-La Roche.  In late September 2002, Hoffmann-La Roche received approval from the European Committee for Proprietary Medicinal Products to manufacture Herceptin at its Penzberg, Germany facility.  The Penzberg facility will become the primary site for the manufacture of Herceptin to supply ex-U.S. territories.  We expect our sales of Herceptin to Hoffmann-La Roche to decline starting in 2003.  However, we will continue to receive royalties from their ex-U.S. sales of Herceptin.

Growth Hormone



Net sales of our four growth hormone products, Nutropin Depot, Nutropin AQ, Nutropin, and Protropin, increased 13% in the first quarter 2003 from the comparable period in 2002.  The increase was attributable to a price increase and continued strong demand for the products.  The continued strong demand reflects our focus on new patient starts using our Nutropin AQ Pen, continued growth in the adult patient market, higher dosing during puberty and an incremental increase in the length of therapy.  In late April 2002, the U.S. Food and Drug Administration (or FDA) approved Nutropin AQ Pen, a new delivery system for Nutropin AQ.  The Nutropin AQ Pen was launched on July 10, 2002.



Page 24

---



Thrombolytics



Combined net sales of our three thrombolytic products, Activase, TNKase and Cathflo Activase, increased 11% in the first quarter of 2003 from the comparable period in 2002.  The increase is primarily due to an increase in sales of Cathflo Activase for catheter clearance.  Cathflo Activase received FDA approval in early September 2001 and was launched in late September 2001.  Additionally, modest increases in Activase usage for acute ischemic stroke are being observed.  The overall size of the thrombolytic market for acute myocardial infarction continues to decline as a result of the increasing use of mechanical reperfusion, early intervention with other therapies in the treatment of acute myocardial infarction, and preventative therapies.

Pulmozyme



Net sales of Pulmozyme increased 25% in the first quarter of 2003 from the comparable period in 2002.  The increase primarily reflects an increased focus on aggressive treatment of cystic fibrosis early in the course of the disease and, to a lesser extent, a price increase.



|Royalties and Contract revenues |      | Three Months
Ended March 31, |       | 
|------------------------------- | ---- | ---------------------------- | ----- | 
|                                |      |                              |       | 
|                                | 2003 |                              | 2002  | 
|                                |      |                              |       | 
|Royalties                       |      | $                            | 113.3 | 
|Contract revenues               |      |                              | 37.9  | 

Royalties



Royalty income increased 39% in the first quarter of 2003 from the comparable period in 2002.  The increase was due to higher third-party sales by various licensees, primarily Hoffmann-La Roche on higher sales of our Herceptin and Rituxan products, including gains on foreign currency exchange rates related to such sales.

Contract Revenues



Contract revenues were higher in the first quarter of 2003 from the comparable period in 2002.  The increase was primarily due to a milestone payment from a third-party collaborator, higher revenues from collaborators and payments from out-licensing a patent to several licensees.



|                                        |  | Three Months
Ended March 31, |       |     
|--------------------------------------- |  | ---------------------------- | ----- | ----
|                                        |  |                              |       |     
|Costs and Expenses                      |  | 2003                         |       | 2002
|                                        |  |                              |       |     
|Cost of sales                           |  | $                            | 114.8 |     
|Research and development                |  |                              | 157.4 |     
|Marketing, general and administrative   |  |                              | 137.2 |     
|Collaboration profit sharing            |  |                              | 96.6  |     
|Recurring charges related to redemption |  |                              | 38.6  |     
|Special charges: Litigation-related     |  |                              | 13.3  |     
|                                        |  |                              |       |     
|Total costs and expenses                |  | $                            | 557.9 |     
|                                        |  |                              |       |     
|                                        |  |                              |       |     
|                                        |  |                              |       |     

Cost of Sales



Cost of sales (or COS) increased 12% in the first quarter of 2003 from the comparable period of 2002.  Cost of sales as a percent of product sales decreased to 19% in the first quarter of 2003 from 21% in the first quarter of 2002.  The decrease in costs as a percent of sales was primarily due to lower production costs for products sold in the first quarter of 2003 and higher royalty costs in the first quarter of 2002 due to a $5.0 million payment for retroactive royalties.

In late September 2002, Hoffmann-La Roche received approval from the European Committee for Proprietary Medicinal Products to manufacture Herceptin at its Penzberg, Germany facility.  The Penzberg facility





Page 25

---





will become the primary site for the manufacture of Herceptin to supply ex-U.S. territories.  We expect our sales of Herceptin to Hoffmann-La Roche to decline starting in 2003.  Accordingly, if our ex- U.S. Herceptin sales decline as expected, our cost as a percent of sales is also expected to decline due to lower gross margins generated by the ex-U.S. Herceptin sales.

Research and Development



Research and development (or R&D) expenses increased 7% in the first quarter of 2003 from the comparable period in 2002.  This increase was largely due to higher development manufacturing expenses, higher clinical development expenses related to products that are primarily in late stage development, including Raptiva, product experience studies and higher research expenses due to an increase in headcount and related expenses.  These increases were offset in part by lower in-licensing expenses in the first quarter of 2003.

The major components of R&D expenses for the quarters ended March 31, 2003 and 2002 were as follows (in millions):



|Research and Development |      | Three Months
Ended March 31, |       | 
|------------------------ | ---- | ---------------------------- | ----- | 
|                         |      |                              |       | 
|                         | 2003 |                              | 2002  | 
|                         |      |                              |       | 
|Research                 |      | $                            | 36.8  | 
|Development              |      |                              | 114.9 | 
|In-licensing             |      |                              | 5.7   | 
|                         |      |                              |       | 
|Total                    |      | $                            | 157.4 | 
|                         |      |                              |       | 
|                         |      |                              |       | 
|                         |      |                              |       | 

Marketing, General and Administrative



Overall marketing, general and administrative (or MG&A) expenses increased 19% in the first quarter of 2003 from the comparable period in 2002 due to higher marketing and selling expenses.  The increase in marketing and selling expenses were primarily due to: (i) a $9.7 million increase in marketing and promotional programs and headcount growth in support of our bio-oncology commercial and pipeline products, including Rituxan and Tarceva; (ii) a $5.3 million increase in headcount growth and other commercial and pipeline promotional programs, including pre-launch activities related Xolair, and (iii) a $3.6 million increase due to headcount growth and an increase in commercial initiatives in support of all products.



Collaboration Profit Sharing



Collaboration profit sharing increased 34% in the first quarter of 2003 from the comparable period in 2002. The increase was primarily due to increased Rituxan profit sharing with IDEC due to higher Rituxan sales.



Recurring Charges Related to Redemption



We began recording recurring charges related to the Redemption and push-down accounting in the first quarter of 1999.  The charges in the first quarter of 2003 were comparable to the first quarter of 2002, and were comprised of the amortization of other intangible assets in both periods.



Special Charges: Litigation-Related



In the first quarter of 2003, we recorded $13.3 million for accrued interest and costs related to the surety bond we obtained in the third quarter of 2002 for the City of Hope trial judgment.  In 2002, we recognized $543.9 million of litigation-related special charges.  These special charges were comprised of the City of Hope litigation judgment in the second quarter of 2002, accrued interest and costs related to obtaining a surety bond, and certain other litigation-related matters.  We expect that we will continue to incur interest charges on the judgment and services fees on the surety bond each quarter through the process of appealing the City of Hope trial results.  These special charges represent our best estimate of the costs for the current resolution of these matters and are included in





Page 26

---





litigation-related and other long-term liabilities in the Condensed Consolidated Balance Sheets at March 31, 2003 and December 31, 2002.  We developed this estimate in consultation with outside counsel handling our defense in these matters and it is based upon the facts and circumstances of these matters known to us at that time.  The amount of our liability for certain of these matters could exceed or be less than the amount of our current estimate, depending on the outcome of these matters.  The amount of cash, if any, paid in connection with the City of Hope matter will depend on the outcome of the appeal.  See Note 2, "Leases and Contingencies," in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 of this Form 10-Q for further information regarding our litigations.

Other Income, Net



As part of our strategic alliance efforts, we invested in debt and equity securities of certain biotechnology companies with which we have or have had collaborative agreements.  "Other income, net" includes realized gains and losses from the sale of certain of these biotechnology equity securities and write-downs for other-than-temporary declines in the fair value of certain of these biotechnology debt and equity securities.  In addition, "other income, net," includes interest income and interest expense, net of amounts capitalized.  "Other "income, net," in the first quarter of 2003 decreased 57% from the comparable quarter in 2002.  The decrease was primarily due to lower gains on sales of biotechnology equity securities, lower interest income as a result of lower yields and lower average cash and investment balances, offset in part by other-than-temporary charges recorded against the carrying values of certain equity securities in biotechnology companies.



|                                                        |  | Three Months
Ended March 31, |       |     
|------------------------------------------------------- |  | ---------------------------- | ----- | ----
|                                                        |  |                              |       |     
|Other Income, Net                                       |  | 2003                         |       | 2002
|                                                        |  |                              |       |     
|Gains on sales of biotechnology equity securities       |  | $                            | 0.5   |     
|Write-downs on biotechnology debt and equity securities |  |                              | (3.7) |     
|Interest income                                         |  |                              | 18.9  |     
|Interest expense                                        |  |                              | -     |     
|                                                        |  |                              |       |     
|Total other income, net                                 |  | $                            | 15.7  |     
|                                                        |  |                              |       |     
|                                                        |  |                              |       |     
|                                                        |  |                              |       |     

Depending on market conditions, we may determine that in future periods certain of our other unhedged biotechnology marketable equity securities are impaired, which could result in additional write-downs of those equity securities.



|Income Before Taxes, Income Tax Provision,
Net Income and Earnings Per Share |      | Three Months
Ended March 31, |       | 
|---------------------------------------------------------------------------- | ---- | ---------------------------- | ----- | 
|                                                                             |      |                              |       | 
|                                                                             | 2003 |                              | 2002  | 
|                                                                             |      |                              |       | 
|Income before taxes                                                          |      | $                            | 207.5 | 
|Income tax provision                                                         |      |                              | 56.0  | 
|Net income                                                                   |      |                              | 151.5 | 
|Earnings per share:                                                          |      |                              |       | 
|Basic                                                                        |      |                              | 0.30  | 
|Diluted                                                                      |      |                              | 0.29  | 



Income Tax Provision



Our effective tax rate was 27% in the first quarter of 2003 compared to 26% in the first quarter of 2002.  The tax provision of $56.0 million in the first quarter of 2003 increased over the tax provision of $33.6 million in the first quarter of 2002 primarily due to increased pretax income and decreased tax credits, partially offset by a $17.0 million favorable change in estimate of prior years items.

We anticipate that our effective tax rate for the year 2003 will be higher than the first quarter of 2003. Other factors may have favorable or unfavorable effects on our effective tax rate during the remainder of 2003 and in subsequent years.  These factors include, but are not limited to, interpretations of existing tax laws, changes in tax laws and rates, future levels of R&D spending, future levels of capital expenditures, and changes in overall levels of pretax earnings.





Page 27

---





Net Income and Earnings Per Share



Net income and diluted earnings per share in the first quarter of 2003 increased from the comparable period of 2002 primarily as a result of higher operating revenues, driven mostly by higher product sales, offset in part by higher operating expenses, lower "other income, net," and a higher tax provision.  The increase in diluted earnings per share was also attributable to a lower weighted average shares outstanding for the first quarter of 2003 compared to the first quarter of 2002.



In-Process Research and Development



At June 30, 1999, the Redemption date, we determined that the acquired in-process technology was not technologically feasible and that the in-process technology had no future alternative uses.  As a result, $500.5 million of in-process research and development (or IPR&D) related to Roche's 1990 through 1997 purchases of our common stock was charged to additional paid-in capital, and $752.5 million of IPR&D related to the Redemption was charged to operations at June 30, 1999.

Except as otherwise noted below, there have been no significant changes to the projects since December 31, 2001.  We do not track all costs associated with research and development on a project-by-project basis.  Therefore, we believe a calculation of cost incurred as a percentage of total incurred project cost as of the FDA approval is not possible.  We estimate, however, that the research and development expenditures that will be required to complete the in-process projects will total at least $385.0 million, as compared to $700.0 million as of the Redemption date.  This estimate reflects costs incurred since the Redemption date, discontinued projects, and decreases in cost to complete estimates for other projects, partially offset by an increase in certain cost estimates related to early stage projects and changes in expected completion dates.

The following are significant changes that occurred during the first three months of 2003, to the projects included in the IPR&D charge at the Redemption:

- Xolair (omalizumab) - We announced that the U.S. Food and Drug Administration's Pulmonary-Allergy Drugs Advisory Committee (PADAC) will review the companies' Biologics License Application (BLA) for XolairTM (Omalizumab) for the treatment of moderate-to-severe allergic asthma in adolescents and adults on May 15, 2003.



- Herceptin antibody - Phase III program studying Herceptin as an adjuvant therapy for breast cancer may take longer to complete than originally anticipated.



- rhuFab V2 (ranibizumab) - We have initiated a Phase III study for patients with the wet form of age-related macular degeneration.

Recent Accounting Pronouncements



In June 2002, the Financial Accounting Standards Board (or FASB) issued FAS 146, "Accounting for Costs Associated with Exit or Disposal Activities," which addresses accounting for restructuring, discontinued operation, plant closing, or other exit or disposal activity.  FAS 146 requires companies to recognize costs associated with exit or disposal activities when they are incurred rather than at the date of a commitment to an exit or disposal plan.  FAS 146 is to be applied prospectively to exit or disposal activities initiated after December 31, 2002.  The adoption of FAS146 on January 1, 2003 did not have a significant impact on our financial position and results of operations.



In November 2002, the FASB issued Interpretation No. 45 (or FIN 45), "Guarantor's Accounting and Disclosure Requirements for Guarantees, Including Indirect Guarantees of Indebtedness of Others."  FIN 45 elaborates on the existing disclosure requirements for most guarantees, including residual value guarantees issued in conjunction with operating lease agreements.  It also clarifies that at the time a company issues a guarantee, the company must recognize an initial liability for the fair value of the obligation it assumes under that guarantee and must disclose that information in its interim and annual financial statements.  The initial recognition and





Page 28

---





measurement provisions apply on a prospective basis to guarantees issued or modified after December 31, 2002.  The disclosure requirements are effective for financial statements of interim or annual periods ending after December 15, 2002.  Our adoption of FIN 45 did not have a material impact on our results of operations and financial position.  See below in "Leases and Contingencies" for a discussion of our exposures related to our agreement with Serono S.A. and our synthetic leases and the related residual value guarantees.



In January 2003, the FASB issued Interpretation No. 46 (or FIN 46), "Consolidation of Variable Interest Entities."  FIN 46 requires a variable interest entity to be consolidated by a company if that company is subject to a majority of the risk of loss from the variable interest entity's activities or entitled to receive a majority of the entity's residual returns or both.  A variable interest entity is a corporation, partnership, trust, or any other legal structures used for business purposes that either (a) does not have equity investors with voting rights or (b) has equity investors that do not provide sufficient financial resources for the entity to support its activities.  A variable interest entity often holds financial assets, including loans or receivables, real estate or other property.  A variable interest entity may be essentially passive or it may engage in research and development or other activities on behalf of another company.  The consolidation requirements of FIN 46 apply immediately to variable interest entities created after January 31, 2003.  The consolidation requirements apply to older entities in the first fiscal year or interim period beginning after June 15, 2003.  Certain of the disclosure requirements apply to all financial statements issued after January 31, 2003, regardless of when the variable interest entity was established.  See below in "Leases and Contingencies" for a discussion of our synthetic leases and the expanded disclosures required by FIN 46.



In December 2002, the FASB issued Statement No. 148, "Accounting for Stock-Based Compensation - Transition and Disclosure."  FAS 148 amends FAS 123 "Accounting for Stock-Based Compensation" to provide alternative methods of transition for a voluntary change to the fair value based method of accounting for stock-based employee compensation.  In addition, FAS 148 amends the disclosure requirements of FAS 123 to require more prominent disclosures in both annual and interim financial statements about the method of accounting for stock-based employee compensation and the effect of the method used on reported results.  The additional disclosure requirements of FAS 148 are effective for fiscal years ending after December 15, 2002.  We have elected to continue to follow the intrinsic value method of accounting as prescribed by Accounting Principles Board Opinion No. 25 (or APB 25), "Accounting for Stock Issued to Employees," to account for employee stock options.  Under APB 25, no compensation expense is recognized unless the exercise price of our employee stock options is less than the market price of the underlying stock on the date of grant.  We have not recorded such expenses in the periods presented because we grant options at the fair market value of the underlying stock on the date of grant.  See Note 1, "Summary of Significant Accounting Policies" in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 of this Form 10-Q for the required disclosures under FAS 148.



Liquidity and Capital Resources



|Liquidity and Capital Resources(in millions)                                                                  |  | March 31, 2003 |   | December 31, 2002
|------------------------------------------------------------------------------------------------------------- |  | -------------- | - | -----------------
|                                                                                                              |  |                |   |                  
|Cash and cash equivalents, short-term investments and
    long-term marketable securities and debt securities |  |                | $ | 1,653.1          
|Working capital                                                                                               |  |                |   | 1,480.0          



We used cash generated from operations, income from investments and proceeds from stock issuances to fund operations, purchase marketable securities, make capital and equity investments and to make stock repurchases during the first quarters of 2003 and 2002, and to redeem our convertible subordinated debentures in the first quarter of 2002.



Under the stock repurchase program approved by our Board of Directors on October 31, 2001, as extended on August 15, 2002, we are authorized to repurchase up to $1 billion of our common stock through the period ending June 30, 2003.  Purchases may be made in the open market or in privately negotiated transactions from time to time at management's discretion.  We may also engage in transactions in other Genentech securities in conjunction with the repurchase program, including derivative securities.  Due to the extension of the stock repurchase program, a new 10b5-1 trading plan was entered into on November 13, 2002, to repurchase shares in the open market during those periods each quarter when trading in our stock is restricted under our insider trading policy.  This plan covers 2.5





Page 29

---





million shares.  Under the stock repurchase program, we repurchased approximately 3.2 million shares of our common stock in the first quarter of 2003 at a cost of approximately $113.2 million.  Of those shares repurchased, approximately 1.2 million were repurchased under our current 10b5-1 insider trading plan.  In the first quarter of 2002, we repurchased 3.7 million shares of our common stock at a cost of approximately $179.9 million.  Of those shares repurchased, approximately 0.3 million were repurchased under our prior 10b5-1 insider trading plan.  Under the stock repurchase program to date, we repurchased approximately 21.5 million shares of our common stock at a cost of approximately $811.6 million during the period from November 1, 2001 through March 31, 2003.



Capital expenditures of $73.5 million in the first quarter of 2003 increased slightly over the  $72.1 million in the comparable period of 2002.

We believe that our cash, cash equivalents and short-term investments, together with funds provided by operations and leasing arrangements, will be sufficient to meet our foreseeable operating cash requirements including any cash utilized under our stock repurchase program.  In addition, we believe we could access additional funds from the debt and, under certain circumstances, capital markets.  See above for a discussion of our leasing arrangements.  See "Our Affiliation Agreement With Roche Could Adversely Affect Our Cash Position" section below and Note 2, "Leases and Contingencies," in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 of this Form 10-Q for factors that could negatively affect our cash position.

LEASES AND CONTINGENCIES



Leases



We lease various real properties under operating leases that generally require us to pay taxes, insurance, maintenance and minimum lease payments.  Some of our leases have options to renew.  Four of our operating leases are commonly referred to as synthetic leases.  A synthetic lease represents a form of off-balance sheet financing under which an unrelated third-party funds 100% of the costs of the acquisition and/or construction of the property and leases the asset to a lessee (Genentech), and at least 3% of the third-party funds represent at-risk equity.  As the lessee, our synthetic leases are treated as operating leases for accounting purposes and as financing leases for tax purposes.  (See also below regarding FIN 46).  Under our synthetic lease structures, upon termination or expiration, at our option, we must either purchase the property from the lessor at a predetermined amount that does not constitute a purchase at less than fair market value, sell the real property to a third-party, or renew the lease arrangement.  If the property is sold to a third-party at an amount less than the amount financed by the lessor, we have agreed under residual value guarantees to pay the lessor up to an agreed upon percentage of the amount financed by the lessor.



Three of our four synthetic leases were entered into with BNP Paribas Leasing Corporation (or BNP), who leases directly to us various buildings that we occupy in South San Francisco, California.  Under certain of these leases, we are required to maintain cash collateral of $56.6 million, which we have included in our Condensed Consolidated Balance Sheets as restricted cash.



The most significant of our synthetic leases relates to our manufacturing facility located in Vacaville, California. In November 2001, we completed a synthetic lease transaction for this facility, which had previously been leased to us under a predecessor synthetic lease.  This new synthetic lease is structured differently from our other synthetic leases.  As the lessee, we lease the property from an unrelated special purpose trust (owner/lessor) under an operating lease agreement for five years ending November 2006.  Third-party financing is provided in the form of a 3% at-risk equity participation from investors and 97% debt commitment.  Investors' equity contributions were equal to or greater than 3% of the fair value of the property at the lease's inception and are required to remain so for the term of the lease.  A bankruptcy-remote, special purpose corporation (SPC) was formed to fund the debt portion through the issuance of commercial paper notes.  The SPC lends the proceeds from the commercial paper to the owner/lessor, who issues promissory notes to the SPC.  The SPC loans mature in November 2006.  The SPC promissory notes are supported by a credit facility provided by financing institutions and draws are generally available under that credit facility to repay the SPC's commercial paper.  The collateral for the SPC loans includes the leased property, and an interest in the residual value guarantee provided by us.  As the lessee, at any time during





Page 30

---





the lease term, we have the option to purchase the property at an amount that does not constitute a purchase at less than fair market value.  Our off-balance sheet contingent liability under the residual value guarantees is summarized in the table below.



Under all the synthetic leases, Genentech, as the lessee, is also required to maintain certain pre-defined financial ratios and is limited to the amount of debt it can assume.  In addition, no Genentech officers or employees have any financial interest with regards to these synthetic lease arrangements or with any of the special purpose entities used in these arrangements.  In the event of a default, the maximum amount payable under the residual value guarantee would equal 100% of the amount financed by the lessor, and our obligation to purchase the leased properties or pay the related residual value guarantees could be accelerated.  We believed at the lease's inception and continue to believe that the occurrence of any event of default that could trigger our purchase obligation is remote.

Future minimum lease payments under operating leases, exclusive of the residual value guarantees, executory costs and sublease income, at December 31, 2002, are as follows (in millions).  These minimum lease payments were computed based on interest rates current at that time, which are subject to fluctuations in certain market-based interest rates:



|                       | 2003 |      | 2004 |   | 2005 |  | 2006 |      | 2007 |   | Thereafter |  | Total
|---------------------- | ---- | ---- | ---- | - | ---- |  | ---- | ---- | ---- | - | ---------- |  | -----
|                       |      |      |      |   |      |  |      |      |      |   |            |  |      
|Synthetic leases       | $    | 9.6  |      | $ | 9.4  |  | $    | 8.8  |      | $ | 8.8        |  | $    
|Other operating leases |      | 4.8  |      |   | 3.3  |  |      | 3.1  |      |   | 2.6        |  |      
|                       |      |      |      |   |      |  |      |      |      |   |            |  |      
|Total                  | $    | 14.4 |      | $ | 12.7 |  | $    | 11.9 |      | $ | 11.4       |  | $    
|                       |      |      |      |   |      |  |      |      |      |   |            |  |      
|                       |      |      |      |   |      |  |      |      |      |   |            |  |      
|                       |      |      |      |   |      |  |      |      |      |   |            |  |      

The following summarizes the approximate assumed carrying values of the leased properties as of December 31, 2002, which represents the initial fair values of the facilities at the inception of the related lease, less assumed depreciation through June 30, 2003, and residual value guarantee amounts for our synthetic leases (in millions):



|                            | Approximate
Initial Fair
Value of
Leased Property |   | Estimated
Accumulated
Depreciation |  | Estimated
Carrying
Value |  | Lease
Expiration |   | Maximum
Residual
Value
Guarantee
|--------------------------- | ------------------------------------------------- | - | ---------------------------------- |  | ------------------------ |  | ---------------- | - | --------------------------------
|                            |                                                   |   |                                    |  |                          |  |                  |   |                                 
|South San Francisco Lease 1 |                                                   | $ | 56.6                               |  |                          |  |                  | $ | 21.4                            
|South San Francisco Lease 2 |                                                   |   | 152.0                              |  |                          |  |                  |   | 29.2                            
|South San Francisco Lease 3 |                                                   |   | 25.0                               |  |                          |  |                  |   | 4.9                             
|Vacaville Lease             |                                                   |   | 425.0                              |  |                          |  |                  |   | 66.0                            
|                            |                                                   |   |                                    |  |                          |  |                  |   |                                 
|Total                       |                                                   | $ | 658.6                              |  |                          |  |                  | $ | 121.5                           
|                            |                                                   |   |                                    |  |                          |  |                  |   |                                 
|                            |                                                   |   |                                    |  |                          |  |                  |   |                                 
|                            |                                                   |   |                                    |  |                          |  |                  |   |                                 

We believe that there have been no impairments in the fair value or use of the properties that we lease under synthetic leases wherein we believe that we would be required to pay amounts under any of the residual value guarantees.  We will continue to assess the fair values of the underlying properties and the use of the properties for impairment on an annual basis.



The maximum exposure to loss on our synthetic leases include (i) residual value guarantee payments as shown above, (ii) certain tax indemnifications in the event the third-parties are obligated for certain federal, state or local taxes as a result of their participation in the transaction, and (iii) indemnification for various losses, costs and expenses incurred by the third-party participants as a result of their ownership of the leased property or participation in the transaction, and as a result of the environmental condition of the property.  The additional taxes, losses and expenses as described in (ii) and (iii) are contingent upon the existence of certain conditions and, therefore, would not be quantifiable at this time.  However, we do not expect these additional taxes, losses and expenses to be material.  In the case of Lease 1, we have pledged cash collateral of $56.6 million as a source of payment for Genentech's obligation for the residual value guarantee payments and other amounts we owe under the lease.

Under the FASB's new rule, FIN 46, "Consolidation of Variable Interest Entities," it is likely that some or all of the above synthetic leasing structures qualify as variable interest entities that Genentech, as the primary beneficiary, would be required to consolidate.  We have determined that the leasing structure used in the Vacaville





Page 31

---





Lease will likely qualify as a variable interest entity under FIN 46.  Accordingly, with respect to our Vacaville Lease, we estimate that we will need to consolidate assets of $359.0 million, net of accumulated depreciation, liabilities of $412.3 million and noncontrolling interests of $12.7 million, and expect to record a charge of $39.6 million, net of tax, as a cumulative effect of an accounting change on July 1, 2003.  With regard to BNP Leases 1, 2 and 3, we are currently evaluating these leases and are seeking additional information from the lessor to determine whether or not we will need to consolidate the related assets under FIN 46 on July 1, 2003.

Contingencies



In August 2002, we entered into an agreement with Serono S.A. to market Raptiva internationally outside the United States, Japan, and certain other Asian countries.  In February 2003, we amended the agreement with Serono to expand Serono's marketing rights to include certain Asian countries other than Japan.  Development and marketing rights in the United States remain with us and our U.S. collaborator, XOMA (US) LLC, and we retain exclusive marketing rights in Japan.  Under the agreement, we and Serono may collaborate on co-developing additional indications of Raptiva and will share certain global development costs.  In addition, we have a supply agreement with Serono, under which we could have a loss exposure up to a maximum of $10.0 million.

We are a party to various legal proceedings, including patent infringement litigation relating to our antibody products, and licensing and contract disputes, and other matters.  See Note 2, "Leases and Contingencies" in the Notes to Condensed Consolidated Financial Statements of Part I, Item 1 of this Form 10-Q for further information.

RELATED PARTY TRANSACTIONS



We enter into transactions with Roche, Hoffmann-La Roche and its affiliates in the ordinary course of business.  Contract revenue from Hoffmann-La Roche, including reimbursement for ongoing development expenses after the option exercise date, totaled $2.1 million in the first quarter of 2003 and $2.1 million in the first quarter of 2002.  All other revenues from Roche, Hoffmann-La Roche and their affiliates, principally royalties and product sales, totaled $76.3 million in the first quarter of 2003 and $47.2 million in the first quarter of 2002.



During 2001, Novartis AG (or Novartis) acquired 21.3% of the outstanding voting shares of Roche Holding Ltd.  During 2002, Novartis acquired an additional 11.4%, bringing its total holdings of the outstanding voting shares of Roche Holding Ltd to 32.7%.  As a result of this investment, Novartis is deemed to have an indirect beneficial ownership interest under FAS 57 "Related Party Disclosures" of more than 10% of Genentech's voting stock.  During 2000, we entered into an arrangement with our collaborator, Novartis, whereby Novartis is required to fund a portion of the cost of our Xolair inventory until the FDA approves the product for marketing.  This amount is required to be returned to Novartis upon the earlier of regulatory approval of Xolair in the U.S. or the European Union, and has been recorded in other accrued liabilities in our financial statements.  The amount payable to Novartis was $37.8 million at March 31, 2003 and December 31, 2002.  Reimbursements for ongoing development expenses were not material in the first quarters of 2003 and 2002.

STOCK OPTIONS

Option Program Description

Our stock option program is a broad-based, long-term retention program that is intended to attract and retain talented employees and to align stockholder and employee interests.  Our program primarily consists of our amended and restated 1999 Stock Plan (the "Plan"), a broad-based plan under which stock options are granted to employees, directors and other service providers.  Substantially all of our employees participate in our stock option program.  In the past, we granted options under our amended and restated 1996 Stock Option/Stock Incentive Plan, our amended and restated 1994 Stock Option Plan and our amended and restated 1990 Stock Option/Stock Incentive Plan.  Although we no longer grant options under these plans, exercisable options granted under these plans are still outstanding.



We also have a stock repurchase program in place and one purpose of the program is to manage the dilutive effect generated by the exercise of stock options.  All stock option grants are made after a review by, and with the





Page 32

---





approval of, the Compensation Committee of the Board of Directors.  See "The Compensation Committee Report" appearing in our 2003 Proxy Statement on file with the Securities and Exchange Commission for further information concerning the policies and procedures of the Compensation Committee regarding the use of stock options.

General Option Information

Summary of Option Activity



|                           |  |                            |  | Options Outstanding
|-------------------------- |  | -------------------------- |  | -------------------
|                           |  |                            |  |                    
|                           |  | Shares
Available
for
Grant |  | Number of
Shares   
|                           |  |                            |  |                    
|December 31, 2001          |  | 14,509                     |  | 46,640             
|                           |  |                            |  |                    
|Grants                     |  | (12,655)                   |  | 12,655             
|Exercises                  |  | -                          |  | (1,673)            
|Cancellations(1)           |  | 2,195                      |  | (2,203)            
|Additional shares reserved |  | -                          |  | -                  
|                           |  |                            |  |                    
|December 31, 2002          |  | 4,049                      |  | 55,419             
|                           |  |                            |  |                    
|                           |  |                            |  |                    
|                           |  |                            |  |                    
|Grants                     |  | (373)                      |  | 373                
|Exercises                  |  | -                          |  | (564)              
|Cancellations(1)           |  | 696                        |  | (696)              
|Additional shares reserved |  | -                          |  | -                  
|                           |  |                            |  |                    
|March  31, 2003            |  | 4,372                      |  | 54,532             
|                           |  |                            |  |                    
|                           |  |                            |  |                    
|                           |  |                            |  |                    

|(1) | We currently only grant shares under our amended and restated 1999 Stock Plan.  Cancellations from options granted under previous plans are not added back to the shares reserved for issuance under the 1999 Stock Plan.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

In-the-Money and Out-of-the-Money Option Information



|                          |  | Exercisable |                          | Unexercisable |        | Total                   
|------------------------- |  | ----------- | ------------------------ | ------------- | ------ | ------------------------
|                          |  |             |                          |               |        |                         
|As of March 31, 2003      |  | Shares      | Wtd. Avg.
Exercise
Price |               | Shares | Wtd. Avg.
Exercise
Price
|                          |  |             |                          |               |        |                         
|In-the-Money              |  | 17,921      |                          | $             | 22.89  |                         
|Out-of-the-Money(1)       |  | 13,478      |                          |               | 55.93  |                         
|                          |  |             |                          |               |        |                         
|Total Options Outstanding |  | 31,399      |                          |               |        |                         
|                          |  |             |                          |               |        |                         
|                          |  |             |                          |               |        |                         
|                          |  |             |                          |               |        |                         

|(1) | Out-of-the-money options are those options with an exercise price equal to or greater than the fair market value of Genentech Common Stock, $35.01, at the close of business on March 31, 2003.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Distribution and Dilutive Effect of Options

Employee and Executive Officer Option Grants



|                                                                                      |  | 2003 |      | 2002 |  | 2001
|------------------------------------------------------------------------------------- |  | ---- | ---- | ---- |  | ----
|                                                                                      |  |      |      |      |  |     
|Net grants during the year as % of outstanding shares                                 |  |      | 0.07 | %    |  |     
|Grants to Named Executive Officers* during the period
    as % of outstanding shares  |  |      | -    | %    |  |     
|Grants to Named Executive Officers during the year 
    as % of total options granted |  |      | -    | %    |  |     

|* | "Named Executive Officers" refers to our CEO and our four other most highly compensated executive officers as defined under Item 402(a)(3) of Regulation S-K of the federal securities laws.
|- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Page 33

---



Equity Compensation Plan Information

All of our equity compensation plans under which options are currently outstanding have been approved by our stockholders.



FORWARD-LOOKING INFORMATION AND CAUTIONARY FACTORS
THAT MAY AFFECT FUTURE RESULTS



The following sections contain forward-looking information based on our current expectations.  Because our actual results may differ materially from any forward-looking statements made by or on behalf of Genentech, this section includes a discussion of important factors that could affect our actual future results, including, but not limited to, our product sales, royalties, contract revenues, expenses, net income and earnings per share.



The Successful Development of Biotherapeutics Is Highly Uncertain



Successful development of biotherapeutics is highly uncertain and is dependent on numerous factors, many of which are beyond our control.  Products that appear promising in the early phases of development may fail to reach the market for several reasons including:



- Preclinical and clinical trial results that may show the product to be less effective than desired (e.g., the trial failed to meet its primary objectives) or to have harmful or problematic side effects.



- Failure to receive the necessary regulatory approvals or a delay in receiving such approvals.  Among other things, such delays may be caused by slow enrollment in clinical studies, length of time to achieve study endpoints, additional time requirements for data analysis, Biologics License Application (or BLA) preparation, discussions with the U.S. Food and Drug Administration (or FDA), an FDA request for additional preclinical or clinical data, or unexpected safety or manufacturing issues.



- Manufacturing costs, pricing or reimbursement issues, or other factors that make the product uneconomical.



- The proprietary rights of others and their competing products and technologies that may prevent the product from being commercialized.



Success in preclinical and early clinical trials does not ensure that large-scale clinical trials will be successful.  Clinical results are frequently susceptible to varying interpretations that may delay, limit or prevent regulatory approvals.  The length of time necessary to complete clinical trials and to submit an application for marketing approval for a final decision by a regulatory authority varies significantly and may be difficult to predict.



Factors affecting our research and development (or R&D) expenses include, but are not limited to:



- The number of and the outcome of clinical trials currently being conducted by us and/or our collaborators.  For example, our R&D expenses may increase based on the number of late-stage clinical trials being conducted by us and/or our collaborators.



- The number of products entering into development from late-stage research.  For example, there is no guarantee that internal research efforts will succeed in generating sufficient data for us to make a positive development decision or that an external candidate will be available on terms acceptable to us.  In the past, some promising candidates did not yield sufficiently positive preclinical results to meet our stringent development criteria.



- Hoffmann-La Roche's decisions whether to exercise its options to develop and sell our future products in non-U.S. markets and the timing and amount of any related development cost reimbursements.





Page 34

---





- In-licensing activities, including the timing and amount of related development funding or milestone payments.  For example, we may enter into agreements requiring us to pay a significant upfront fee for the purchase of in-process research and development (or IPR&D), which we may record as an R&D expense.



- As part of our strategy, we invest in R&D.  R&D as a percent of revenues can fluctuate with the changes in future levels of revenue.  Lower revenues can lead to more limited spending on R&D efforts.



- Future levels of revenue.



We May Be Unable to Obtain or Maintain Regulatory Approvals for Our Products



The biotechnology and pharmaceutical industries are subject to stringent regulation with respect to product safety and efficacy by various international, federal, state and local authorities.  Of particular significance are the FDA's requirements covering R&D, testing, manufacturing, quality control, labeling and promotion of drugs for human use.  A biotherapeutic cannot be marketed in the United States until it has been approved by the FDA, and then can only be marketed for the indications and claims approved by the FDA.  As a result of these requirements, the length of time, the level of expenditures and the laboratory and clinical information required for approval of a New Drug Application (or NDA) or a BLA, are substantial and can require a number of years.  In addition, after any of our products receive regulatory approval, they remain subject to ongoing FDA regulation, including, for example, changes to the product label, new or revised regulatory requirements for manufacturing practices, written advisements to physicians and a product recall.



We cannot be sure that we can obtain necessary regulatory approvals on a timely basis, if at all, for any of the products we are developing or that we can maintain necessary regulatory approvals for our existing products, and all of the following could have a material adverse effect on our business:



- Significant delays in obtaining or failing to obtain required approvals as described in "The Successful Development of Biotherapeutics is Highly Uncertain" above.



- Loss of, or changes to, previously obtained approvals.



- Failure to comply with existing or future regulatory requirements.



- Changes to manufacturing processes, manufacturing process standards or Good Manufacturing Practices following approval or changing interpretations of these factors.



Moreover, it is possible that the current regulatory framework could change or additional regulations could arise at any stage during our product development or marketing, which may affect our ability to obtain or maintain approval of our products.



Difficulties or Delays in Product Manufacturing Could Harm Our Business



We currently produce all of our products at our manufacturing facilities located in South San Francisco, California and Vacaville, California or through various contract manufacturing arrangements.  Problems with any of our or our contractors' manufacturing processes could result in failure to produce adequate product supplies or product defects, which could require us to delay shipment of products, recall products previously shipped or be unable to supply products at all.

In addition, any prolonged interruption in the operations of our or our contractors' manufacturing facilities could result in cancellations of shipments, loss of product in the process of being manufactured, or a shortfall of available product inventory.  A number of factors could cause interruptions, including equipment malfunctions or failures, damage to a facility due to natural disasters, including earthquakes as our South San Francisco facilities are located in an area where earthquakes could occur, changes in FDA regulatory requirements or standards that require modifications to our manufacturing processes, action by the FDA that results in the halting of production of one or





Page 35

---





more of our products due to regulatory issues, a contract manufacturer going out of business or other similar factors.  Because our manufacturing processes and those of our contractors are highly complex and are subject to a lengthy FDA approval process, alternative qualified production capacity may not be available on a timely basis or at all.  Difficulties or delays in our and our contractors' manufacturing and supply of existing or new products could increase our costs, cause us to lose revenue or market share and damage our reputation.  We may also experience insufficient available capacity to manufacture existing or new products which could cause shortfalls of available product inventory or we may have an excess of available capacity  which could lead to an idling of a portion of our manufacturing facilities and incurring idle plant costs, resulting in an increase in our costs of sales.



Protecting Our Proprietary Rights Is Difficult and Costly



The patent positions of pharmaceutical and biotechnology companies can be highly uncertain and involve complex legal and factual questions.  Accordingly, we cannot predict the breadth of claims allowed in these companies' patents.  Patent disputes are frequent and can preclude the commercialization of products.  We have in the past been, are currently, and may in the future be, involved in material patent litigation, such as the matters discussed in Note 2, "Leases and Contingencies," in the Notes to Condensed Consolidated Financial Statements of Part I, Item 1 of this Form 10-Q.  Patent litigation is costly in its own right and could subject us to significant liabilities to third parties.  In addition, an adverse decision could force us to either obtain third-party licenses at a material cost or cease using the technology or product in dispute.



The presence of patents or other proprietary rights belonging to other parties may lead to our termination of the R&D of a particular product.



We believe that we have strong patent protection or the potential for strong patent protection for a number of our products that generate sales and royalty revenue or that we are developing.  However, it is for the courts in the U.S. and in other jurisdictions ultimately to determine the strength of that patent protection.



The Outcome of, and Costs Relating to, Pending Litigation Are Uncertain



Litigation to which we are currently or have been subjected relates to, among other things, our patent and other intellectual property rights, licensing arrangements with other persons, product liability and financing activities.  We cannot predict with certainty the eventual outcome of pending litigation, which may include an injunction of the manufacture or sale of a product or potential product or a significant jury verdict or punitive damages award, or a judgment that certain of our patent or other intellectual property rights are invalid or unenforceable.  Furthermore, we may have to incur substantial expense in defending these lawsuits.



We May Be Unable to Retain Skilled Personnel and Maintain Key Relationships



The success of our business depends, in large part, on our continued ability to attract and retain highly qualified management, scientific, manufacturing and sales and marketing personnel, and on our ability to develop and maintain important relationships with leading research institutions and key distributors.  Competition for these types of personnel and relationships is intense.



Roche has the right to maintain its percentage ownership interest in our common stock.  Our affiliation agreement with Roche provides that, among other things, we will establish a stock repurchase program designed to maintain Roche's percentage ownership in our common stock if we issue or sell any shares.  This could have an effect on the number of shares we are able to grant under our stock option plans.  We therefore cannot assure you that we will be able to attract or retain skilled personnel or maintain key relationships.



We Face Growing and New Competition



We face growing competition in two of our therapeutic markets and expect new competition in a third market.  First, in the thrombolytic market, Activase has lost market share and could lose additional market share to Centocor's Retavase® either alone or in combination with the use of another Centocor product, ReoPro®





Page 36

---





(abciximab) and to the use of mechanical reperfusion therapies to treat acute myocardial infarction; the resulting adverse effect on sales has been and could continue to be material.  Retavase received approval from the FDA in October 1996 for the treatment of acute myocardial infarction. We expect that the use of mechanical reperfusion in lieu of thrombolytic therapy for the treatment of acute myocardial infarction will continue to grow.  In addition, we face potential increased competition in the catheter clearance market from the reintroduction of Abbott Laboratories' Abbokinase® (urokinase).



Second, in the growth hormone market, we continue to face competition from other companies currently selling growth hormone products and delivery devices.  As a result of that competition, we have experienced a loss in market share in the past.  Competitors have also received approval to market their existing human growth hormone products for additional indications.  As a result of this competition, market share of our growth hormone products may decline.  In addition, we have certain patents related to the production of growth hormone that have expired or are expiring soon and as a consequence those patents would no longer exclude others from making growth hormone using the processes claimed by those patents.



Third, in the non-Hodgkin's lymphoma market, Corixa Corporation filed a revised BLA and received a positive review by the FDA's Oncology Drugs Advisory Committee in December 2002, for BexxarTM (tositumomab and iodine I 131 tositumomab), which may potentially compete with our product Rituxan.  IDEC received marketing approval from the FDA and began commercial shipments in late March 2002 for ZevalinTM (ibritumomab tiuxetan), a product which could also potentially compete with Rituxan.  Both Bexxar and Zevalin are radiolabeled molecules while Rituxan is not.  We are also aware of other potentially competitive biologic therapies for non-Hodgkin's lymphoma in development.



Other Competitive Factors Could Affect Our Product Sales



Other competitive factors that could affect our product sales include, but are not limited to:



- The timing of FDA approval, if any, of competitive products.



- Our pricing decisions, including a decision to increase or decrease the price of a product, and the pricing decisions of our competitors.



- Government and third-party payer reimbursement and coverage decisions that affect the utilization of our products and competing products.



- Negative data from new clinical studies could cause the utilization and sales of our products to decrease.



- The degree of patent protection afforded our products by patents granted to us and by the outcome of litigation involving our patents.



- The outcome of litigation involving patents of other companies concerning our products or processes related to production and formulation of those products or uses of those products.  For example, as described in Note 2, "Leases and Contingencies," in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 of this Form 10-Q, at various times other companies have filed patent infringement lawsuits against us alleging that the manufacture, use and sale of certain of our products infringe their patents.



- The increasing use and development of alternate therapies.  For example, the overall size of the market for thrombolytic therapies, such as our Activase product, continues to decline as a result of the increasing use of mechanical reperfusion.



- The rate of market penetration by competing products.  For example, we have lost market share to new competitors in the thrombolytic and, in the past, growth hormone markets.





Page 37

---





Our Royalty and Contract Revenues Could Decline



Royalty and contract revenues in future periods could vary significantly.  Major factors affecting these revenues include, but are not limited to:



- Hoffmann-La Roche's decisions whether to exercise its options and option extensions to develop and sell our future products in non-U.S. markets and the timing and amount of any related development cost reimbursements.



- Variations in Hoffmann-La Roche's sales and other licensees' sales of licensed products.



- The expiration or termination of existing arrangements with other companies and Hoffmann-La Roche, which may include development and marketing arrangements for our products in the U.S., Europe and other countries outside the United States.



- The timing of non-U.S. approvals, if any, for products licensed to Hoffmann-La Roche and to other licensees.



- Fluctuations in foreign currency exchange rates.



- The initiation of new contractual arrangements with other companies.



- Whether and when contract benchmarks are achieved.



- The failure of or refusal of a licensee to pay royalties.



- The expiration or invalidation of our patents or licensed intellectual property.



- Decreases in licensees' sales of product due to competition, manufacturing difficulties or other factors that affect the sales of product.



We May Incur Material Product Liability Costs



The testing and marketing of medical products entail an inherent risk of product liability. Liability exposures for biotherapeutics could be extremely large and pose a material risk.  Our business may be materially and adversely affected by a successful product liability claim or claims in excess of any insurance coverage that we may have.



Insurance Coverage Is Increasingly More Difficult to Obtain or Maintain



While we currently have insurance for our business, property and our products, first- and third-party insurance is increasingly more costly and narrower in scope, and we may be required to assume more risk in the future.  If we are subject to third-party claims or suffer a loss or damage in excess of our insurance coverage, we may be required to share that risk in excess of our insurance limits.  Furthermore, any first- or third-party claims made on our insurance policy may impact our ability to obtain or maintain insurance coverage at reasonable costs or at all in the future.



Other Risks



We generally deal with some hazardous materials in connection with our research and manufacturing activities.  In the event such hazardous materials are stored, handled or released into the environment in violation of law or any permit, we could be subject to loss of our permits, government fines or penalties and/or other adverse governmental action. The levy of a substantial fine or penalty, the payment of significant environmental remediation costs or the loss of a permit or other authorization to operate or engage in our ordinary course of business could materially adversely affect our business.





Page 38

---





Fluctuations in Our Operating Results Could Affect the Price of Our Common Stock



Our operating results may vary from period to period for several reasons including:



- The overall competitive environment for our products as described in "We Face Growing and New Competition" above.



- The amount and timing of sales to customers in the United States.  For example, sales of a product may increase or decrease due to pricing changes, fluctuations in distributor buying patterns or sales initiatives that we may undertake from time to time.



- The amount and timing of our sales to Hoffmann-La Roche and our other collaborators of products for sale outside of the United States and the amount and timing of sales to their respective customers, which directly impact both our product sales and royalty revenues.



- The timing and volume of bulk shipments to licensees.



- The availability and extent of government and private third-party reimbursements for the cost of therapy.



- The extent of product discounts extended to customers.



- The effectiveness and safety of our various products as determined both in clinical testing and by the accumulation of additional information on each product after it is approved by the FDA for sale.



- The rate of adoption and use of our products for approved indications and additional indications.  Among other things, the rate of adoption and use of our products may be affected by results of clinical studies reporting on the benefits or risks of a product.



- The potential introduction of new products and additional indications for existing products.



- The ability to successfully manufacture sufficient quantities of any particular marketed product.



- The number and size of any product price increases we may issue.



Our Stock Price, Like That of Many Biotechnology Companies, Is Highly Volatile



The market prices for securities of biotechnology companies in general have been highly volatile and may continue to be highly volatile in the future.  In addition, the market price of our common stock has been and may continue to be volatile.



In addition, the following factors may have a significant impact on the market price of our common stock:



- Announcements of technological innovations or new commercial products by us or our competitors.



- Developments or outcome of litigation, including litigation regarding proprietary and patent rights.



- Publicity regarding actual or potential medical results relating to products under development or being commercialized by us or our competitors.



- Regulatory developments or delays concerning our products in the United States and foreign countries.



- Issues concerning the safety of our products or of biotechnology products generally.





Page 39

---





- Economic and other external factors or a disaster or crisis.



- Period-to-period fluctuations in our financial results.



In Connection with the Redemption of Our Special Common Stock, We Recorded Substantial Goodwill and Other Intangibles, the Amortization or Impairment of Which May Adversely Affect Our Earnings



As a result of the redemption of our Special Common Stock, Roche owned all of our outstanding common stock.  Consequently, push-down accounting under generally accepted accounting principles in the U.S. was required.  Push-down accounting required us to establish a new accounting basis for our assets and liabilities, based on Roche's cost in acquiring all of our stock.  In other words, Roche's cost of acquiring Genentech was "pushed down" to us and reflected on our financial statements.  Push-down accounting required us to record goodwill of approximately $1,685.7 million and other intangible assets of $1,499.0 million on June 30, 1999.  The other intangible assets are being amortized over their estimated useful lives ranging from 5 to 15 years.  See Note 4, "Goodwill and Other Intangible Assets" in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 of this Form 10-Q for further information on these other intangible assets.



Statement of Financial Accounting Standards (or FAS) No. 142, "Goodwill and Other Intangible Assets," which was adopted January 1, 2002, requires that goodwill not be amortized, but rather be subject to an impairment test at least annually.  Separately identified and recognized intangible assets resulting from business combinations completed before July 1, 2001, that did not meet the new criteria under FAS 141, "Business Combinations," for separate recognition of intangible assets have been reclassified into goodwill upon adoption.  These intangible assets included our trained and assembled workforce.  In addition, the useful lives of recognized intangible assets acquired in transactions completed before July 1, 2001, will be reassessed at each reporting date and the remaining amortization periods adjusted accordingly.  At least annually, we will evaluate whether events and circumstances have occurred that indicate the remaining balance of goodwill and other intangible assets may not be recoverable.  If our evaluation of the assets results in a possible impairment, we may have to reduce the carrying value of our intangible assets.  This could have a material adverse effect on our financial condition and results of operations during the periods in which we recognize a reduction.  We may have to write down intangible assets in future periods.  We performed an impairment test of goodwill at transition on January 1, 2002, and an annual impairment test on September 30, 2002, and found no impairment.  For more information, see Note 3, "Relationship With Roche -- Redemption of Our Special Common Stock" and Note 4, "Goodwill and Other Intangible Assets" in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 of this Form 10-Q.

Future Stock Repurchases Could Adversely Affect Our Cash Position



On October 31, 2001, our Board of Directors authorized a stock repurchase program to repurchase up to 13.0 million shares for an amount not to exceed $625.0 million of our common stock over a 12 month period.  On August 15, 2002, our Board of Directors authorized an extension of the stock repurchase program through June 30, 2003, for the repurchase of additional shares for an amount not to exceed an additional $375.0 million of our common stock, increasing the program to a total of approximately 29.6 million shares and an amount not to exceed a total of $1.0 billion.  Purchases may be made in the open market or in privately negotiated transactions from time to time at management's discretion.  We may also engage in transactions in other Genentech securities in conjunction with the repurchase program, including derivative securities.  We also entered into a 10b5-1 insider trading plan on February 8, 2002, to repurchase shares in the open market during those periods each quarter when trading in our stock by insiders is restricted under our insider trading policy.  Under its terms, the 10b5-1 plan terminated on October 11, 2002, the date on which a total of 3.0 million shares had been purchased under the plan during the period from February 8, 2002 to October 11, 2002.  Due to the extension of the stock repurchase program, a new 10b5-1 trading plan was entered into on November 13, 2002, to repurchase shares in the open market during those periods each quarter when trading in our stock is restricted under our insider trading policy. This plan covers 2.5 million shares.  Under the stock repurchase program approved by our Board of Directors, we repurchased approximately 3.2 million shares of our common stock in the first quarter of 2003 at a cost of approximately $113.2 million.  Of those shares repurchased, approximately 1.2 million were purchased under our current 10b5-1 insider trading plan. In the first quarter of 2002, we repurchased 3.7 million shares of our common stock at a cost of approximately $179.9 million.





Page 40

---





Of those shares repurchased, approximately 0.3 million were repurchased under our prior 10b5-1 insider trading plan.  Under the stock repurchase program to date, we repurchased approximately 21.5 million shares of our common stock at a cost of approximately $811.6 million during the period from November 1, 2001, through March 31, 2003.



While the dollar amounts associated with these future stock repurchases cannot currently be estimated, these stock repurchases could have a material adverse effect on our cash position, interest income, credit rating and ability to access capital in the financial markets, and could limit our ability to use our capital stock as consideration for acquisitions.  For more information on our stock repurchase program, see the "Liquidity and Capital Resources" section above and the item immediately following.



Our Affiliation Agreement with Roche Could Adversely Affect Our Cash Position



Our affiliation agreement with Roche provides that we establish a stock repurchase program designed to maintain Roche's percentage ownership interest in our common stock based on an established Minimum Percentage.  For more information on our stock repurchase program, see Note 9, "Capital Stock" in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 of this Form 10-Q.  See Note 3, "Relationship With Roche -- Roche's Ability to Maintain Its Percentage Ownership Interest in Our Stock" in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 of this Form 10-Q for information regarding the Minimum Percentage.



While the dollar amounts associated with these future stock repurchases cannot currently be estimated, these stock repurchases could have a material adverse effect on our cash position, and may have the effect of limiting our ability to use our capital stock as consideration for acquisitions.



Future Sales of Our Common Stock by Roche Could Cause the Price of Our Common Stock to Decline



As of March 31, 2003, Roche owned 306,594,352 shares of our common stock or 60.1% of our outstanding shares.  All of our shares owned by Roche are eligible for sale in the public market subject to compliance with the applicable securities laws.  We have agreed that, upon Roche's request, we will file one or more registration statements under the Securities Act in order to permit Roche to offer and sell shares of our common stock.  Sales of a substantial number of shares of our common stock by Roche in the public market could adversely affect the market price of our common stock.



Roche Holdings, Inc., Our Controlling Stockholder, May Have Interests That Are Adverse to Other Stockholders



Roche as our majority stockholder, controls the outcome of actions requiring the approval of our stockholders.  Our bylaws provide, among other things, that the composition of our board of directors shall consist of two Roche directors, three independent directors nominated by a nominating committee and one Genentech employee nominated by the nominating committee.  As long as Roche owns in excess of 50% of our common stock, Roche directors will comprise two of the three members of the nominating committee.  However, at any time until Roche owns less than 5% of our stock, Roche will have the right to obtain proportional representation on our board.  Roche intends to continue to allow our current management to conduct our business and operations as we have done in the past.  However, we cannot assure stockholders that Roche will not institute a new business plan in the future.  Roche's interests may conflict with minority shareholder interests.



Our Affiliation Agreement with Roche Could Limit Our Ability to Make Acquisitions and Could Have a Material Negative Impact on Our Liquidity



The affiliation agreement between us and Roche contains provisions that:



- Require the approval of the directors designated by Roche to make any acquisition or any sale or disposal of all or a portion of our business representing 10% or more of our assets, net income or revenues.



- Enable Roche to maintain its percentage ownership interest in our common stock.





Page 41

---





- Require us to establish a stock repurchase program designed to maintain Roche's percentage ownership interest in our common stock based on an established Minimum Percentage.  For information regarding Minimum Percentage, see Note 3, "Relationship With Roche -- Roche's Ability to Maintain Its Percentage Ownership Interest in Our Stock" in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 of this Form 10-Q.  For more information on our stock repurchase program, see Note 9, "Capital Stock" in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 of this Form 10-Q.



These provisions may have the effect of limiting our ability to make acquisitions and while the dollar amounts associated with the stock repurchase program cannot currently be estimated, these stock repurchases could have a material adverse impact on our liquidity, credit rating and ability to access additional capital in the financial markets.



Our Stockholders May Be Unable to Prevent Transactions That Are Favorable to Roche but Adverse to Us



Our certificate of incorporation includes provisions relating to:



- Competition by Roche with us.



- Offering of corporate opportunities.



- Transactions with interested parties.



- Intercompany agreements.



- Provisions limiting the liability of specified employees.



Our certificate of incorporation provides that any person purchasing or acquiring an interest in shares of our capital stock shall be deemed to have consented to the provisions in the certificate of incorporation relating to competition with Roche, conflicts of interest with Roche, the offer of corporate opportunities to Roche and intercompany agreements with Roche.  This deemed consent may restrict the ability to challenge transactions carried out in compliance with these provisions.



Potential Conflicts of Interest Could Limit Our Ability to Act on Opportunities That Are Adverse to Roche



Persons who are directors and/or officers of Genentech and who are also directors and/or officers of Roche may decline to take action in a manner that might be favorable to us but adverse to Roche.  Two of our directors, Dr. Franz B. Humer and Dr. Jonathan K.C. Knowles, currently serve as officers and employees of Roche Holding Ltd and its affiliates, and Dr. Humer is a director of Roche Holding Ltd.



We Are Exposed to Market Risk



We are exposed to market risk, including changes to interest rates, foreign currency exchange rates and equity investment prices.  To reduce the volatility relating to these exposures, we enter into various derivative hedging transactions pursuant to our investment and risk management policies and procedures.  We do not use derivatives for speculative purposes.



We maintain risk management control systems to monitor the risks associated with interest rates, foreign currency exchange rates and equity investment price changes, and our derivative and financial instrument positions.  The risk management control systems use analytical techniques, including sensitivity analysis and market values.  Though we intend for our risk management control systems to be comprehensive, there are inherent risks that may only be partially offset by our hedging programs should there be unfavorable movements in interest rates, foreign currency exchange rates or equity investment prices.



The estimated exposures discussed below are intended to measure the maximum amount we could lose from adverse market movements in interest rates, foreign currency exchange rates and equity investment prices, given a





Page 42

---





specified confidence level, over a given period of time.  Loss is defined in the value at risk estimation as fair market value loss.  The exposures to interest rate, foreign currency exchange rate and equity investment price changes are calculated based on proprietary modeling techniques from a Monte Carlo simulation value at risk model using a 21-trading days holding period and a 95% confidence level.  The value at risk model assumes non-linear financial returns and generates potential paths various market prices could take and tracks the hypothetical performance of a portfolio under each scenario to approximate its financial return.  The value at risk model takes into account correlations and diversification across market factors, including interest rates, foreign currencies and equity prices.  Hedge instruments are modeled as positions on the actual underlying securities.  No proxies were used.  Market volatilities and correlations are based on one year historical times-series provided by J.P. Morgan RiskmetricsTM as of December 31, 2002.



Our Interest Income Is Subject to Fluctuations in Interest Rates



Our material interest-bearing assets, or interest-bearing portfolio, consisted of cash, cash equivalents, restricted cash, short-term investments, convertible preferred stock investments, nonmarketable debt securities, long-term investments and interest-bearing forward contracts.  The balance of our interest-bearing portfolio, including restricted and unrestricted cash, was $2,081.6 million or 30% of total assets at March 31, 2003.  Interest income related to this portfolio was $18.9 million in the first quarter of 2003.  Our interest income is sensitive to changes in the general level of interest rates, primarily U.S. interest rates.  In this regard, changes in U.S. interest rates affect the interest-bearing portfolio.  To mitigate the impact of fluctuations in U.S. interest rates, for a portion of our portfolio, we may enter into swap transactions which involve the receipt of fixed rate interest and the payment of floating rate interest without the exchange of the underlying principal.



Based on our overall interest rate exposure at December 31, 2002, including derivative and other interest rate sensitive instruments, a near-term change in interest rates, within a 95% confidence level based on historical interest rate movements could result in a potential loss in fair value of our interest rate sensitive instruments of $14.1 million.



We Are Exposed to Risks Relating to Foreign Currency Exchange Rates and Foreign Economic Conditions



We receive royalty revenues from licensees selling products in countries throughout the world.  As a result, our financial results could be significantly affected by factors such as changes in foreign currency exchange rates or weak economic conditions in the foreign markets in which our licensed products are sold.  We are exposed to changes in exchange rates in Europe, Asia (primarily Japan) and Canada.  Our exposure to foreign exchange rates primarily exists with the Swiss franc.  When the dollar strengthens against the currencies in these countries, the dollar value of foreign-currency denominated revenue decreases; when the dollar weakens, the dollar value of the foreign-currency denominated revenues increases.  Accordingly, changes in exchange rates, and in particular a strengthening of the dollar, may adversely affect our royalty revenues as expressed in dollars.  Exchange rate exposures on these royalties are being offset by expenses arising from our foreign manufacturing facility as well as non-dollar expenses incurred in our collaborations.  Currently, our foreign royalty revenues exceed our foreign expenses.  In addition, as part of our overall investment strategy, a portion of our portfolio is primarily in non-dollar denominated investments.  As a result, we are exposed to changes in the exchange rates of the countries in which these non-dollar denominated investments are made.



To mitigate our net foreign exchange exposure, our policy allows us to hedge certain of our anticipated royalty revenues by purchasing option contracts with expiration dates and amounts of currency that are based on 25% to 90% of probable future revenues so that the potential adverse impact of movements in currency exchange rates on the non-dollar denominated revenues will be at least partly offset by an associated increase in the value of the option.  Generally, the term of these options is one to five years.  To hedge the non-dollar expenses arising from our foreign manufacturing facility, we may enter into forward contracts to lock in the dollar value of a portion of these anticipated expenses.



Based on our overall currency rate exposure at December 31, 2002, including derivative and other foreign currency sensitive instruments, a near-term change in currency rates within a 95% confidence level based on historical currency rate movements would not materially affect the fair value of our foreign currency sensitive instruments.





Page 43

---





Our Investments in Equity Securities Are Subject to Market Risks



As part of our strategic alliance efforts, we invest in equity instruments of biotechnology companies.  Our biotechnology equity investment portfolio totaled $258.1 million or 4% of total assets at March 31, 2003.  These investments are subject to fluctuations from market value changes in stock prices.  For example, in 2002, we recorded charges related to the write-down of certain equity security investments that had other than temporary impairments.



To mitigate the risk of market value fluctuation, certain equity securities are hedged with zero-cost collars and forward contracts.  A zero-cost collar is a purchased put option and a written call option in which the cost of the purchased put and the proceeds of the written call offset each other; therefore, there is no initial cost or cash outflow for these instruments at the time of purchase.  The purchased put protects us from a decline in the market value of the security below a certain minimum level (the put "strike" level), while the call effectively limits our potential to benefit from an increase in the market value of the security above a certain maximum level (the call "strike" level).  A forward contract is a derivative instrument where we lock-in the termination price we receive from the sale of stock based on a pre-determined spot price.  The forward contract protects us from a decline in the market value of the security below the spot price and limits our potential benefit from an increase in the market value of the security above the spot price.  Throughout the life of the contract, we receive interest income based on the notional amount and a floating-rate index.  In addition, as part of our strategic alliance efforts, we hold dividend-bearing convertible preferred stock and have made interest-bearing loans that are convertible into the equity securities of the debtor or repaid in cash.  Depending on market conditions, we may determine that in 2003 certain of our other unhedged equity security investments are impaired, which would result in additional write-downs of those equity security investments.



Based on our overall exposure to fluctuations from market value changes in marketable equity prices at December 31, 2002, a near-term change in equity prices within a 95% confidence level based on historic volatilities could result in a potential loss in fair value of our equity securities portfolio of $23.0 million.



We Are Exposed to Credit Risk of Counterparties



We could be exposed to losses related to the financial instruments described above should one of our counterparties default.  We attempt to mitigate this risk through credit monitoring procedures.



The Company's Effective Tax Rate May Vary Significantly



Various internal and external factors may have favorable or unfavorable effects on our future effective tax rate.  These factors include but are not limited to changes in tax laws, regulations and/or rates, changing interpretations of existing tax laws or regulations, future levels of R&D spending, future levels of capital expenditures, and changes in overall levels of pretax earnings.



New and Potential New Accounting Pronouncements May Impact Our Future Financial Position and Results of Operations

On June 30, 2002, the Financial Accounting Standards Board (or FASB) issued FAS 146, "Accounting for Costs Associated with Exit or Disposal Activities," which addresses accounting for restructuring, discontinued operation, plant closing, or other exit or disposal activity.  FAS 146 requires companies to recognize costs associated with exit or disposal activities when they are incurred rather than at the date of a commitment to an exit or disposal plan.  FAS 146 is to be applied prospectively to exit or disposal activities initiated after December 31, 2002.  The adoption of FAS 146 is not expected to have a significant impact on our financial position and results of operations.



In November 2002, the FASB issued Interpretation No. 45 (or FIN 45), "Guarantor's Accounting and Disclosure Requirements for Guarantees, Including Indirect Guarantees of Indebtedness of Others."  FIN 45 elaborates on the existing disclosure requirements for most guarantees, including residual value guarantees issued in conjunction with operating lease agreements.  It also clarifies that at the time a company issues a guarantee, the





Page 44

---





company must recognize an initial liability for the fair value of the obligation it assumes under that guarantee and must disclose that information in its interim and annual financial statements.  The initial recognition and initial measurement provisions apply on a prospective basis to guarantees issued or modified after December 31, 2002.  The disclosure requirements are effective for financial statements of interim or annual periods ending after December 15, 2002.  Our adoption of FIN 45 is not expected to have a material impact on our results of operations and financial position.  See above in "Leases and Contingencies" for a discussion of our synthetic leases and the related residual value guarantees and our exposure related to our agreement with Serono S.A.



In January 2003, the FASB issued Interpretation No. 46 (or FIN 46), "Consolidation of Variable Interest Entities."  FIN 46 requires a variable interest entity to be consolidated by a company if that company is subject to a majority of the risk of loss from the variable interest entity's activities or entitled to receive a majority of the entity's residual returns or both.  A variable interest entity is a corporation, partnership, trust, or any other legal structures used for business purposes that either (a) does not have equity investors with voting rights or (b) has equity investors that do not provide sufficient financial resources for the entity to support its activities.  A variable interest entity often holds financial assets, including loans or receivables, real estate or other property.  A variable interest entity may be essentially passive or it may engage in research and development or other activities on behalf of another company.  The consolidation requirements of FIN 46 apply immediately to variable interest entities created after January 31, 2003.  The consolidation requirements apply to older entities in the first fiscal year or interim period beginning after June 15, 2003.  Certain of the disclosure requirements apply to all financial statements issued after January 31, 2003, regardless of when the variable interest entity was established.  See above in "Leases and Contingencies" for a discussion of our synthetic leases and the expanded disclosures.



There may be potential new accounting pronouncements or regulatory rulings which may have an impact on our future financial position and results of operations. In particular, there are a number of rule changes and proposed legislative initiatives following the recent corporate bankruptcies and failures which could result in changes in accounting rules, including the accounting for employee stock options as an expense. These and other potential changes could materially impact our assets and liabilities, and the expenses we report under generally accepted accounting principles, and could adversely affect our operating results or financial condition.



Page 45

---



Item 3.  Quantitative and Qualitative Disclosures About Market Risk

Our market risks at March 31, 2003 have not changed significantly from those discussed in Item 7A of our Form 10-K for the year ended December 31, 2002 on file with the Securities and Exchange Commission.  See Note 5, "Derivative Financial Instruments," in the Notes to Condensed Consolidated Financial Statements in Part I, Item 1 and the "Forward-Looking Information and Cautionary Factors That May Affect Future Results--We Are Exposed to Market Risk" section of Item 2 of this Form 10-Q for additional discussions of our market risks.



Item 4.  Controls and Procedures

(a) Evaluation of disclosure controls and procedures:  The Company's principal executive and financial officers reviewed and evaluated the Company's disclosure controls and procedures (as defined in Exchange Act Rule 13a-14) as of a date within 90 days before the filing date of this Form 10-Q.  Based on that evaluation, the Company's principal executive and financial officers concluded that the Company's disclosure controls and procedures are effective in timely providing them with material information relating to the Company, as required to be disclosed in the reports the Company files under the Exchange Act.



(b) Changes in internal controls:  There were no significant changes in the Company's internal controls or other factors that could significantly affect those controls subsequent to the date of the Company's evaluation, including any corrective actions with regard to significant deficiencies and material weaknesses.



Page 46

---



PART II - OTHER INFORMATION

Item 1.  Legal Proceedings



We are a party to various legal proceedings, including patent infringement litigation relating to our antibody products, and licensing and contract disputes, and other matters.



In the shareholder derivative suit filed by Green Equity, LLC, on March 6, 2003, the U.S. District Court issued an order granting in part and denying in part the defendants' motions to dismiss.  The Court dismissed the Complaint against Genentech and all the individual defendants, except for Jonathan K.C. Knowles.  The Court dismissed the Complaint against Knowles with leave to amend for failure to allege proper standing.  On April 7, 2003, Green Equity, LLC and an additional plaintiff, Warren Jones, filed another amended Complaint against Genentech as nominal defendant and against Dr. Knowles and several other members of our Board of Directors.



In the arbitration proceeding between Genentech and Tanox, as a general matter, the claims are divided into two categories: (1) compensation for lost rights under agreements with Genentech and Novartis, and (2) additional royalties on future sales.  The arbitration hearing began on January 13, 2003.  Tanox closed its case on January 30, 2003, and Genentech closed its case on March 30, 2003.  A decision in the arbitration is expected on or before June 13, 2003.



On April 11, 2003, MedImmune, Inc. filed a lawsuit against Genentech, City of Hope National Medical Center, and Celltech R & D Ltd. in the U.S. District Court for the Central District of California (Los Angeles).  The lawsuit relates to U.S. Patent No. 6,331,415 ("the '415 patent) that is co-owned by Genentech and City of Hope and under which MedImmune and other companies have been licensed and are paying royalties to Genentech.  The lawsuit includes claims for violation of antitrust, patent, and unfair competition laws.  MedImmune is seeking to have the '415 patent declared invalid and/or unenforceable, a determination that MedImmune does not owe royalties under the '415 patent on sales of its Synagis® antibody product, an injunction to prevent Genentech from enforcing the '415 patent, an award of actual and exemplary damages, and other relief.



See also Item 3 of our report on Form 10-K for the period ended December 31, 2002.



See also Note 2, "Leases and Contingencies," note in the Notes to Condensed Consolidated Financial Statements of Part I.

Item 6.  Exhibits and Reports on Form 8-K

| | (a) | Exhibits            
| | --- | --------------------
| |     |                     
| |     | (i)                 
| |     |                     
| |     | (ii)                
| |     |                     
| |     | (iii)               
| |     |                     
| | (b) | Reports on Form 8-K.
| |     |                     
| |     |                     



Page 47

---



SIGNATURES



Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.





|      |                 |  | GENENTECH, INC.                                                           
|----- | --------------- |  | --------------------------------------------------------------------------
|Date: | April  30, 2003 |  | /s/ARTHUR D. LEVINSON                                                     
|      |                 |  |                                                                           
|      |                 |  | Arthur D. Levinson, Ph.D.
Chairman, President and
Chief Executive Officer 
|      |                 |  |                                                                           
|      |                 |  |                                                                           
|Date: | April  30, 2003 |  | /s/LOUIS J. LAVIGNE, JR.                                                  
|      |                 |  |                                                                           
|      |                 |  | Louis J. Lavigne, Jr.
Executive Vice President and
Chief Financial Officer
|      |                 |  |                                                                           
|      |                 |  |                                                                           
|Date: | April  30, 2003 |  | /s/JOHN M. WHITING                                                        
|      |                 |  |                                                                           
|      |                 |  | John M. Whiting
Vice President, Controller and
Chief Accounting Officer   



Page 48

---



CERTIFICATIONS

I, Arthur D. Levinson, certify that:

1.   I have reviewed this quarterly report on Form 10-Q of Genentech, Inc.;

2.   Based on my knowledge, this quarterly report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this quarterly report;

3.   Based on my knowledge, the financial statements, and other financial information included in this quarterly report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this quarterly report;

4.   The registrant's other certifying officers and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-14 and 15d-14) for the registrant and we have:

a)   designed such disclosure controls and procedures to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this quarterly report is being prepared;

b)   evaluated the effectiveness of the registrant's disclosure controls and procedures as of a date within 90 days prior to the filing date of this quarterly report (the "Evaluation Date"); and

c)   presented in this quarterly report our conclusions about the effectiveness of the disclosure controls and procedures based on our evaluation as of the Evaluation Date;

5.   The registrant's other certifying officers and I have disclosed, based on our most recent evaluation, to the registrant's auditors and the audit committee of registrant's board of directors (or persons performing the equivalent function):

a)   all significant deficiencies in the design or operation of internal controls which could adversely affect the registrant's ability to record, process, summarize and report financial data and have identified for the registrant's auditors any material weaknesses in internal controls; and

b)   any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal controls; and

6.   The registrant's other certifying officers and I have indicated in this quarterly report whether or not there were significant changes in internal controls or in other factors that could significantly affect internal controls subsequent to the date of our most recent evaluation, including any corrective actions with regard to significant deficiencies and material weaknesses.





|Date: | April  30, 2003 |  | By: | /s/ARTHUR D. LEVINSON                                          
|----- | --------------- |  | --- | ---------------------------------------------------------------
|      |                 |  |     |                                                                
|      |                 |  |     | Arthur D. Levinson, Ph.D.
President and Chief Executive Officer



Page 49

---



I, Louis J. Lavigne, Jr., certify that:

1.   I have reviewed this quarterly report on Form 10-Q of Genentech, Inc.;

2.   Based on my knowledge, this quarterly report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this quarterly report;

3.   Based on my knowledge, the financial statements, and other financial information included in this quarterly report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this quarterly report;

4.   The registrant's other certifying officers and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-14 and 15d-14) for the registrant and we have:

a)   designed such disclosure controls and procedures to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this quarterly report is being prepared;

b)   evaluated the effectiveness of the registrant's disclosure controls and procedures as of a date within 90 days prior to the filing date of this quarterly report (the "Evaluation Date"); and

c)   presented in this quarterly report our conclusions about the effectiveness of the disclosure controls and procedures based on our evaluation as of the Evaluation Date;

5.   The registrant's other certifying officers and I have disclosed, based on our most recent evaluation, to the registrant's auditors and the audit committee of registrant's board of directors (or persons performing the equivalent function):

a)   all significant deficiencies in the design or operation of internal controls which could adversely affect the registrant's ability to record, process, summarize and report financial data and have identified for the registrant's auditors any material weaknesses in internal controls; and

b)   any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal controls; and

6.   The registrant's other certifying officers and I have indicated in this quarterly report whether or not there were significant changes in internal controls or in other factors that could significantly affect internal controls subsequent to the date of our most recent evaluation, including any corrective actions with regard to significant deficiencies and material weaknesses.





|Date: | April  30, 2003 |  | By: | /s/LOUIS J. LAVIGNE, JR.                                                  
|----- | --------------- |  | --- | --------------------------------------------------------------------------
|      |                 |  |     |                                                                           
|      |                 |  |     | Louis J. Lavigne, Jr.
Executive Vice President and
Chief Financial Officer



Page 50

---