**EXHIBIT      10.1**

**FOURTH      AMENDMENT**

**TO      THE**

**MANUFACTURING      AND SUPPLY AGREEMENT OF DECEMBER 7 2003**

**4**
**th**

**      Amendment**
**LB**
**Lonza      Inc**
**Lonza**
**Genentech**

**BACKGROUND**

**1**
**st**

**      Amendment**
**2**
**nd**

**      Amendment**
**3**
**rd**

**      Amendment**
**Agreement**

| **1****.** | **[*]                Repack.**Lonza                shall repack the [*]                Column                with [*].                Lonza shall use its Commercially Reasonable Best Efforts to schedule                such                repacking so as to minimize any impact to the manufacturing schedule.                Subject to the foregoing, Lonza shall schedule such repacking to                occur                [*]. |
|------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| **2.** | **Loss                of Commercial Runs as a Result of [*] Repack**.                ** **It                is understood and agreed by the Parties that such repacking and subsequent                testing of the [*]                Column (as described above in Section 1 of this 4th                Amendment) may result in unexpected delays to the manufacturing schedule                which could jeopardize the quality of one or more Commercial Run(s)                commenced and in process during the [*].                If as a result of such repacking and testing (and not for any other                act or                omission of Lonza), the quality of one or more of such Commercial                Run(s)                are compromised such that Lonza has to discontinue and/or discard                one or                more of such |
|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| **3.** | **Milestone                Payment for Calendar Year 2006**.                In                addition to the foregoing, if as a result of such repacking and testing                (and                not for any other act or omission of Lonza), the quality of one or                more of                such Commercial Run(s) in the [*]                are compromised such that Lonza has to discontinue and/or discard                one or                more of such Commercial Run(s), Genentech                agrees to credit one of such lost Commercial Runs as [*] solely for                the                purpose of determining whether Lonza has met the milestone set forth                in                Section 6.4.3(d)(ii) of the Agreement |
|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| **4.** | All                terms and conditions of the Agreement not modified by this 4th                Amendment shall continue in full force and effect in accordance with                their                terms. All capitalized terms not otherwise defined herein shall have                the                same definition as in the                Agreement. |
|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| GENENTECH,                INC.       |                                                                       |
|--------------------------------------|----------------------------------------------------------------------------|
|                                 |                                                                       |   |
| By:                                  | /s/  PHILIPPA                NORMAN                              |   |
|                                 |                                                                       |   |
| Name:                                | Philippa                Norman                                             |   |
|                                 |                                                                       |   |
| Title:                               | Vice                President, Manufacturing                Collaborations |   |
|                                 |                                                                       |   |
|                                 |                                                                       |   |
| LONZA                BIOLOGICS, INC. |                                                                       |
|                                 |                                                                       |   |
| By:                                  | /s/  STEPHAN                KUTZER                               |   |
|                                 |                                                                       |   |
| Name:                                | Stephan                Kutzer                                              |   |
|                                 |                                                                       |   |
| Title:                               | Chief                Operating Officer                                     |   |
|                                 |                                                                       |   |
|                                 |                                                                       |   |
| LONZA                BIOLOGICS, PLC  |                                                                       |
|                                 |                                                                       |   |
| By:                                  | /s/  STEPHAN                KUTZER                               |   |
|                                 |                                                                       |   |
| Name:                                | Stephan                Kutzer                                              |   |
|                                 |                                                                       |   |
| Title:                               | Chief                Operating Officer                                     |   |

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