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 VIDEOS

Progress Towards an Understanding of Shape Recognition in Liquid Chromatography

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  Lane C. SanderChemical Sciences DivisionMaterial Measurement LaboratoryNational Institute of Standards and TechnologyGaithersburg, MD   20899The development of alkyl modified surfaces represents one of the milestones of modern liquid chromatography (LC). Such surfaces are not true liquids or solids, but instead exhibit properties intermediate to these states of matter. Retention processes in LC depend on interactions of solute and mobile phase molecules with each other, and with the stationary phase.  The ambiguous nature of alkyl stationary phases is at the core of theories of solute retention advanced over the past 30 years: is retention in reversed-phase LC better represented by adsorption or partitioning? Mounting evidence supports a model for alkyl phases as ordered states of matter.  The order imposed by such alkyl chain configurations directly affects the chromatographic properties of the stationary phase.  This presentation will summarize findings related to stationary phase conformational order, obtained from spectroscopic and computational studies, for correlation with chromatographic performance.This presentation was first given at the Stephen Dal Nogare Award Symposium, Orlando, FL on March 1, 2010.

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