**Exhibit      31.1**

**CERTIFICATION**

| 1.     | I                have reviewed this Amendment No. 2 to quarterly report on Form 10–Q of the                Company for the fiscal quarter ended July 31, 2005;                                                                                                                                                                                                                                                                                  |
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| 2.     | Based                on my knowledge, this quarterly report does not contain any untrue                statement of a material fact or omit to state a material fact necessary                in                order to make the statements made, in light of the circumstances                under                which such statements were made, not misleading with respect to the                period                covered by this report; |
| 3.     | Based                on my knowledge, the financial statements, and other financial information                included in this report, fairly present in all material respects                the                financial condition, results of operations and cash flows of the                Company                as of, and for, the period presented in this report;                                                                         |
| 4.     | The                Company’s other certifying officer and I are responsible for establishing                and maintaining disclosure controls and procedures (as defined in                Exchange                Act Rules 13a–14 and 15d–14) for the Company and we                have:                                                                                                                                       |
|   | (a)                                                                                                                                                                                                                                                                                                                                                                                                                                                   | designed                such disclosure controls and procedures, or caused such disclosure                controls and procedures to be designed under our supervision, to                ensure                that material information relating to the Company, including its                consolidated subsidiaries, is made known to us by others within those                entities, particularly during the period in which this report was                being                prepared; |
|   | (b)                                                                                                                                                                                                                                                                                                                                                                                                                                                   | designed                such internal control over financial reporting, or caused such internal                control over financial reporting to be designed under our supervision,                to                provide reasonable assurance regarding the reliability of financial                reporting and the preparation of financial statements for external                purposes in accordance with generally accepted accounting                principles; |
|   | (c)                                                                                                                                                                                                                                                                                                                                                                                                                                                   | evaluated                the effectiveness of the Company’s disclosure controls and procedures and                presented in this report our conclusions about the effectiveness                of the                disclosure controls and procedures, as of the end of the period covered                by                this report based on such evaluation; and |
|   | (d)                                                                                                                                                                                                                                                                                                                                                                                                                                                   | disclosed                in this report any change in the Company’s internal control over financial                reporting that occurred during the Company’s most recent fiscal quarter                that has materially affected, or is reasonably likely to materially                affect                the Company’s internal control over financial reporting;                and |

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| 5.     | The                Company’s other certifying officer and I have disclosed, based on our most                recent evaluation, to the Company’s auditors and the audit committee of                the Company’s board of directors: |
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|   | (a)                                                                                                                                                                                                                                                     | all                significant deficiencies and material weaknesses in the design or                operation of internal control over financial reporting which are                reasonably likely to adversely affect the Company’s ability to record,                process, summarize and report financial information;                and |
|        | (b)                                                                                                                                                                                                                                                     | any                fraud, whether or not material, that involves management or                other employees who have a significant role in the Company’s internal                control over financial reporting. |

| /s/                George G. Usher                            |
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| Chief                Executive Officer                        |
|                                                          |
| Polydex                Pharmaceuticals                Limited |

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