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| 1. | I have reviewed the Form 10-K of Chembio Diagnostics, Inc.; |
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| 2. | Based on my knowledge, the report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such                statements were made, not misleading with respect to the period covered by the report; |
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| 3. | Based on my knowledge, the financial statements, and other financial information included in the report, fairly present in all material respects the financial condition, results of operations and cash flows of the                registrant as of, and for, the periods presented in the report; |
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| 4. | The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal                control over financial reporting (as defined in Exchange Act Rules 13a15(f) and 15d-15(f)) for the registrant and have: |
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|  | (a) | Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including                its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which the report is being prepared; |
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|  | (b) | Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of                financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles; |
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|  | (c) | Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in the report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of                the period covered by the report based on such evaluation; and |
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|  | (d) | Disclosed in the report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case                of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and |
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| 5. | The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the                registrant’s board of directors (or persons performing the equivalent functions): |
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|  | (a) | All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record,                process, summarize and report financial information; and |
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|  | (b) | Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting. |
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| Date: May 6, 2020 | /s/ Richard L. Eberly                 |   |
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|              | Richard L. Eberly                     |   |
|              | Chief Executive Officer and President |   |

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