Federal Register / Vol. 79, No. 247 / Wednesday, December 24, 2014 / Notices 77517 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Prospective Grant of Start-Up 

Exclusive Commercialization License: 

Anti-Tyrosine Kinase-Like Orphan 

Receptor 1 Immunotoxins for the 

Treatment of Human Cancers 

AGENCY: National Institutes of Health, 

HHS. 

ACTION: Notice. 

SUMMARY: This is notice, in accordance 

with 35 U.S.C. 209 and 37 CFR part 404, 

that the National Institutes of Health, 

Department of Health and Human 

Services, is contemplating the grant of a 

start-up exclusive commercialization 

license to practice the inventions 

embodied in U.S. Patent Application 

61/172,099 entitled ‘‘Anti-human ROR1 

Antibodies’’ [HHS Ref. E–097–2009/0– 

US–01], U.S. Patent Application No. 13/ 

990,977 entitled, ‘‘Chimeric Rabbit/

Human ROR1 Antibodies’’ filed June 7, 

2013 [HHS Ref. No. E–039–2011/0], U.S. 

Patent Application 60/703,798 entitled 

‘‘Mutated Pseudomonas Exotoxins with 

Reduced Antigenicity’’ [HHS Ref. E– 

262–2005/0–US–01], U.S. Patent 

Application 60/969,929 entitled 

‘‘Deletions in Domain II of 

Pseudomonas Exotoxin A that Remove 

Immunogenic Epitopes with Affecting 

Cytotoxic Activity’’ [HHS Ref. E–292– 

2007/0–US–01], U.S. Patent Application 

61/241,620 entitled ‘‘Improved 

Pseudomonas Exotoxin A with Reduced 

Immunogenicity’’ [HHS Ref. E–269– 

2009/0–US–01], U.S. Patent Application 

61/483,531 entitled ‘‘Recombinant 

Immunotoxin Targeting Mesothelin’’ 

[HHS Ref. E–117–2011/0–US–01], U.S. 

Patent Application 61/495,085 entitled 

‘‘Pseudomonas Exotoxin A with Less 

Immunogenic T-Cell/or B-Cell 

Epitopes’’ [HHS Ref. E–174–2011/0– 

US–01], U.S. Patent Application 61/

535,668 entitled ‘‘Pseudomonas 

Exotoxin A with Less Immunogenic BCell Epitopes’’ [HHS Ref. E–263–2011/

0–US–01], and any PCT, US or foreign 

applications claiming benefit of the 

technology families, to Magnifygen, Inc. 

The patent rights in these inventions 

have been assigned to the Government 

of the United States of America. 

The prospective exclusive license 

territory may be worldwide and the 

field of use may be limited to the 

development and use of immunotoxins 

comprising an anti-tyrosine kinase-like 

orphan receptor 1 monoclonal antibody 

designated as 2A2, R11, R12, or Y31 and 

Pseudomonas exotoxin A for the 

treatment of human cancers as claimed 

within the scope of the Licensed Patent 

Rights. For avoidance of doubt, the 

Licensed Field of Use excludes the 

development of antibody-drug 

conjugates and bispecific antibodies 

comprising said antibodies. 

DATES: Only written comments and/or 

applications for a license which are 

received by the NIH Office of 

Technology Transfer on or before 

January 8, 2015 will be considered. 

ADDRESSES: Requests for copies of the 

patent applications, inquiries, 

comments, and other materials relating 

to the contemplated exclusive license 

should be directed to: Jennifer Wong, 

M.S., Senior Licensing and Patenting 

Manager, Office of Technology Transfer, 

National Institutes of Health, 6011 

Executive Boulevard, Suite 325, 

Rockville, MD 20852–3804; Telephone: 

(301) 435–4633; Facsimile: (301) 402– 

0220; Email: wongje@od.nih.gov. 

SUPPLEMENTARY INFORMATION: This 

invention concerns antiROR1immunotoxin comprising an antiROR1antibody designated as 2A2, R11, 

R12 or Y31 and Pseuodomonas 

Exotoxin A (PE) as treatment for human 

ROR1 expressing cancers. The 

immunotoxin will comprise a chimeric 

mouse anti-human receptor tyrosine 

kinase-like orphan receptor 1 

monoclonal antibody whereas the 

immunotoxin will have a toxin domain 

derived from PE. PE toxin’s domain 

have been modified in various ways in 

order to reduce the immunogenicity of 

the molecule to improve its therapeutic 

value while at the same time 

maintaining the toxin’s ability to trigger 

cell death. The immunotoxin provides 

targeted cytotoxic delivery to cancer 

cells while sparing normal cells thereby 

resulting in therapies with fewer side 

effects. 

The prospective start-up exclusive 

commercialization license is being 

considered under the small business 

initiative launched on October 1, 2011 

and will comply with the terms and 

conditions of 35 U.S.C. 209 and 37 CFR 

part 404. The prospective exclusive 

license may be granted unless the NIH 

receives written evidence and argument 

that establishes that the grant of the 

license would not be consistent with the 

requirements of 35 U.S.C. 209 and 37 

CFR part 404 within fifteen (15) days 

from the date of this published notice. 

Any additional, properly filed, and 

complete applications for a license in 

the field of use filed in response to this 

notice will be treated as objections to 

the grant of the contemplated exclusive 

license. Comments and objections 

submitted to this notice will not be 

made available for public inspection 

and, to the extent permitted by law, will 

not be released under the Freedom of 

Information Act, 5 U.S.C. 552. 

Dated: December 19, 2014. 

Richard U. Rodriguez, 

Acting Director, Office of Technology 

Transfer, National Institutes of Health. 

[FR Doc. 2014–30259 Filed 12–23–14; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HOUSING AND 

URBAN DEVELOPMENT 

[Docket No. FR–5752–N–115] 

30-Day Notice of Proposed Information 

Collection: Report of Additional 

Classification and Rate 

AGENCY: Office of the Chief Information 

Officer, HUD. 

ACTION: Notice. 

SUMMARY: HUD has submitted the 

proposed information collection 

requirement described below to the 

Office of Management and Budget 

(OMB) for review, in accordance with 

the Paperwork Reduction Act. The 

purpose of this notice is to allow for an 

additional 30 days of public comment. 

DATES: Comments Due Date: January 23, 

2015. 

ADDRESSES: Interested persons are 

invited to submit comments regarding 

this proposal. Comments should refer to 

the proposal by name and/or OMB 

Control Number and should be sent to: 

HUD Desk Officer, Office of 

Management and Budget, New 

Executive Office Building, Washington, 

DC 20503; fax: 202–395–5806. Email: 

OIRA_Submission@omb.eop.gov. 

FOR FURTHER INFORMATION CONTACT: 

Anna Guido, Reports Management 

Officer, QDAM, Department of Housing 

and Urban Development, 451 7th Street 

SW., Washington, DC 20410; email at 

Anna_Guido@hud.gov or telephone 

202–402–5535. Persons with hearing or 

speech impairments may access this 

number through TTY by calling the tollfree Federal Relay Service at (800) 877– 

8339. This is not a toll-free number. 

Copies of available documents 

submitted to OMB may be obtained 

from Ms. Guido. 

SUPPLEMENTARY INFORMATION: This 

notice informs the public that HUD has 

submitted to OMB a request for 

approval of the information collection 

described in Section A. 

The Federal Register notice that 

solicited public comment on the 

information collection for a period of 60 

days was published on October 24, 

2014. 

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77518 Federal Register / Vol. 79, No. 247 / Wednesday, December 24, 2014 / Notices 

A. Overview of Information Collection 

Title of Information Collection: Report 

of Additional Classification and Rate. 

OMB Approval Number: 2501–0011. 

Type of Request: Reinstatement 

without change of a previously 

approved collection. 

Form Number: HUD FORM 4230A, 

HUD FORM 4750, HUD FORM 4751, 

HUD FORM 4752. 

Description of the need for the 

information and proposed use: The 

information is used by HUD and 

agencies administering HUD programs 

to collect information from laborers and 

mechanics employed on projects 

subjected to the Federal Labor 

Standards provisions. The information 

collected is compared to information 

submitted by the respective employer 

on certified payroll reports. The 

comparison tests the accuracy of the 

employer’s payroll data and may 

disclose violations. Generally, these 

activities are geared to the respondent’s 

benefit that is to determine whether the 

respondent was underpaid and to 

ensure the payment of wage restitution 

to the respondent. 

Estimation of the total numbers of 

hours needed to prepare the information 

collection including number of 

respondents, frequency of response, and 

hours of response: Estimated number of 

burden hours is 5,000. Estimated 

number of respondents is 20,000, the 

estimated number of responses is 

20,000, the frequency of response is on 

occasion, and the burden hour per 

response is .25. 

B. Solicitation of Public Comment 

This notice is soliciting comments 

from members of the public and affected 

parties concerning the collection of 

information described in Section A on 

the following: 

(1) Whether the proposed collection 

of information is necessary for the 

proper performance of the functions of 

the agency, including whether the 

information will have practical utility; 

(2) The accuracy of the agency’s 

estimate of the burden of the proposed 

collection of information; 

(3) Ways to enhance the quality, 

utility, and clarity of the information to 

be collected; and 

(4) Ways to minimize the burden of 

the collection of information on those 

who are to respond; including through 

the use of appropriate automated 

collection techniques or other forms of 

information technology, e.g., permitting 

electronic submission of responses. 

HUD encourages interested parties to 

submit comment in response to these 

questions. 

Authority: Section 3507 of the Paperwork 

Reduction Act of 1995, 44 U.S.C. Chapter 35. 

Dated: December 18, 2014. 

Anna Guido, 

Department Reports Management Officer, 

Office of the Chief Information Officer. 

[FR Doc. 2014–30246 Filed 12–23–14; 8:45 am] 

BILLING CODE 4210–67–P 

DEPARTMENT OF HOUSING AND 

URBAN DEVELOPMENT 

[Docket No. FR–5752–N–114] 

30-Day Notice of Proposed Information 

Collection: Management Reviews of 

Multifamily Housing Programs 

AGENCY: Office of the Chief Information 

Officer, HUD. 

ACTION: Notice. 

SUMMARY: HUD has submitted the 

proposed information collection 

requirement described below to the 

Office of Management and Budget 

(OMB) for review, in accordance with 

the Paperwork Reduction Act. The 

purpose of this notice is to allow for an 

additional 30 days of public comment. 

DATES: Comments Due Date: January 23, 

2015. 

ADDRESSES: Interested persons are 

invited to submit comments regarding 

this proposal. Comments should refer to 

the proposal by name and/or OMB 

Control Number and should be sent to: 

HUD Desk Officer, Office of 

Management and Budget, New 

Executive Office Building, Washington, 

DC 20503; fax: 202–395–5806. Email: 

OIRA_Submission@omb.eop.gov. 

FOR FURTHER INFORMATION CONTACT: 

Colette Pollard, Reports Management 

Officer, QDAM, Department of Housing 

and Urban Development, 451 7th Street 

SW., Washington, DC 20410; email at 

Colette_Pollard@hud.gov or telephone 

202–402–3400. Persons with hearing or 

speech impairments may access this 

number through TTY by calling the tollfree Federal Relay Service at (800) 877– 

8339. This is not a toll-free number. 

Copies of available documents 

submitted to OMB may be obtained 

from Ms. Pollard. 

SUPPLEMENTARY INFORMATION: This 

notice informs the public that HUD has 

submitted to OMB a request for 

approval of the information collection 

described in Section A. 

The Federal Register notice that 

solicited public comment on the 

information collection for a period of 60 

days was published on October 20, 

2014. 

A. Overview of Information Collection 

Title of Information Collection: 

Management Review for Multifamily 

Housing Projects. 

OMB Approval Number: 2502–0178. 

Type of Request: Extension of a 

currently approved collection. 

Form Number: HUD–9834. 

Description of the need for the 

information and proposed use: This 

information collection is used by HUD, 

by Mortgagees, and by Contract 

Administrators (CAs) to evaluate the 

quality of project management; 

determine the causes of project 

problems; devise corrective actions to 

stabilize projects and prevent defaults; 

and to ensure that fraud, waste and 

mismanagement are not problems for 

the community. The information 

collected also supports enforcement 

actions when owners fail to implement 

corrective actions. 

Respondents: Business or other forprofit. 

Estimated Number of Responses: 

24,112. 

Frequency of Response: Annually 8. 

Average Hours per Response: 40. 

Total Estimated Burdens: 194,896. 

B. Solicitation of Public Comment 

This notice is soliciting comments 

from members of the public and affected 

parties concerning the collection of 

information described in Section A on 

the following: 

(1) Whether the proposed collection 

of information is necessary for the 

proper performance of the functions of 

the agency, including whether the 

information will have practical utility; 

(2) The accuracy of the agency’s 

estimate of the burden of the proposed 

collection of information; 

(3) Ways to enhance the quality, 

utility, and clarity of the information to 

be collected; and 

(4) Ways to minimize the burden of 

the collection of information on those 

who are to respond; including through 

the use of appropriate automated 

collection techniques or other forms of 

information technology, e.g., permitting 

electronic submission of responses. 

HUD encourages interested parties to 

submit comment in response to these 

questions. 

Authority: Section 3507 of the Paperwork 

Reduction Act of 1995, 44 U.S.C. Chapter 35. 

Dated: December 18, 2014. 

Colette Pollard, 

Department Reports Management Officer, 

Office of the Chief Information Officer. 

[FR Doc. 2014–30250 Filed 12–23–14; 8:45 am] 

BILLING CODE 4210–67–P 

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