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 Institute for Bioscience and Biotechnology Research (IBBR)
                      IBBR is a joint research institute, located in Rockville, Maryland in the heart of the I-270 Technology corridor, formed by the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology (NIST).

      
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          BrochureIBBR exists to foster integrated, cross-disciplinary team approaches to scientific discovery, translational development and education, – and to the foster and expand the bioeconomy in the state of Maryland and across the country.  IBBR works towards these goals by:Leveraging the collective research strengths of the partnering institutions in medicine, biosciences, technology, quantitative sciences and engineering.Creating innovative cross-functional collaborations that break down traditional silos and lead to pioneering research and development.Working with a wide range of academic, government and industry partners to move ideas from promising theory to real-world applications.Find out more on the IBBR website.

    
  News and Updates
      
                          NIST, Partners Develop Living Reference Material for Producing Monoclonal Antibodies
                        January 11, 2023Publicly available NISTCHO cell line expands the biomanufacturing and research applications of NIST’s monoclonal antibody standard, NISTmAb.
  Spotlight: NIST Researchers Analyze the Novavax Vaccine From Multiple Angles
                        August 29, 2022A team of three NIST researchers, each with unique expertise, is studying a vaccine developed by biotech company Novavax for SARS-CoV-2, the virus that causes
  NIST Clarifies Structure of Prospective Vaccine for Respiratory Virus
                        December 16, 2020No approved vaccine exists for RSV, a life-threatening virus that attacks the respiratory system. State-of-the-art neutron and X-ray scattering performed at the
  NIST 2D NMR ‘Fingerprinting’ Study Gives Biopharmaceutical Sector New Power to Assure High Quality Monoclonal Antibody Therapeutics
                        December 20, 2018Researchers at the National Institute of Standards and Technology (NIST) recently completed a large international study * that establishes two-dimensional

    

  
  

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  Publications
      
                          Monitoring Spectrometer Drift with Unsupervised Machine Learning
                        November 20, 2023
                  Author(s)
                                Benjamin  Harding,   Ziling  Hu,   Ashley  Hiett,   Frank  Delaglio,   Katherine  Henzler- Wildman,   Chad  RienstraSolid-state NMR spectroscopy (SSNMR) is a powerful technique to probe structural and dynamic properties of molecules at an atomic level. Modern SSNMR methods
  Divalent ions as mediators of carbonylation in cardiac myosin binding protein C
                        November 1, 2023
                  Author(s)
                                Christina  Bergonzo,   Baikuntha  Aryal,   Ashutosh  RaoThe dosing and efficacy of chemotherapeutic drugs can be limited by toxicity caused by off-pathway reactions. One hypothesis for how such toxicity arises is via
  Effects of Glycans and Hinge on Dynamics in the IgG1 Fc
                        October 28, 2023
                  Author(s)
                                Christina  Bergonzo,   J. Todd  Hoopes,   Zvi  Kelman,   David Travis  GallagherThe crystallizable fragment (Fc) domain of immunoglobulin subclass IgG1 antibodies is engineered for a wide variety of pharmaceutical applications. Two
  The emerging landscape of single-molecule protein sequencing technologies
                        April 11, 2023
                  Author(s)
                                Zvi  Kelman,   John  MarinoSingle-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the

    

  
  

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  Awards
      
                          2021 - Silver Medal Award---Jeffrey Hudgens, Kyle Anderson, Ioannis Karageorgos, Robert Brinson, III, Frank Delaglio, Luke Arbogast, John Marino, Ryan Evans, Anthony KearsleyFor developing and promoting adoption of methods to determine protein structure that increase patient access to life-saving biosimilar drugs.
  2020 - Gold Medal Award---Nancy Lin, James Filliben, Lindsay Harris, Zvi Kelman, Sandra Da Silva, Steven Lund, Nathanael Olson, Jennifer VerkouterenFor developing a suite of standards, including the first NIST living reference material, to strengthen the nation's response to potential biothreats.
  2016 - Silver Medal Award---Luke Arbogast, Robert Brinson, John MarinoFor Nuclear Magnetic Resonance methods that determine the atomic structure of monoclonal antibody biopharmaceuticals with unprecedented resolution.
  John Marino Honored with Hillebrand PrizeJohn Marino is recognized for his groundbreaking contributions to the field of biophysical characterization by high-resolution NMR and

    

  
  

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