EX-10.1



 Exhibit 10.1 

Confidential Materials omitted and filed separately with the 

Securities and Exchange Commission. Double asterisks denote omissions. 

COLLABORATION 
 AND LICENSE
AGREEMENT 
 by and between 

AGIOS PHARMACEUTICALS, INC. 
 and

 CELGENE CORPORATION 
 Re:

 AGI-23088 
 for the 

US Territory 







 TABLE OF CONTENTS 
  

									
	 	 	 	 	 	  	PAGE	 
			
	 ARTICLE I
	 	 DEFINITIONS
	  	 	1	  
			
	 ARTICLE II
	 	 GOVERNANCE; COLLABORATION
	  	 	13	  
				
	 Section 2.1
	 		 	     General
	  	 	13	  
				
	 Section 2.2
	 		 	     Joint Steering Committee
	  	 	15	  
				
	 Section 2.3
	 		 	     Joint Development Committee
	  	 	15	  
				
	 Section 2.4
	 		 	     Joint Commercialization Committee
	  	 	16	  
				
	 Section 2.5
	 		 	     Joint Patent Committee
	  	 	17	  
				
	 Section 2.6
	 		 	     Alliance Managers
	  	 	18	  
				
	 Section 2.7
	 		 	     General Committee Membership and Procedures
	  	 	18	  
				
	 Section 2.8
	 		 	     Decision Making
	  	 	19	  
				
	 Section 2.9
	 		 	     Finance Working Group
	  	 	21	  
				
	 Section 2.10
	 		 	     Scope of Governance
	  	 	23	  
				
	 Section 2.11
	 		 	     Agios Participation
	  	 	23	  
				
	 Section 2.12
	 		 	     Agios Opt-Out
	  	 	23	  
			
	 ARTICLE III
	 	 DEVELOPMENT
	  	 	26	  
				
	 Section 3.1
	 		 	     Development of Licensed Products
	  	 	26	  
				
	 Section 3.2
	 		 	     Development Costs
	  	 	27	  
				
	 Section 3.3
	 		 	     Additional Development Activities
	  	 	27	  
				
	 Section 3.4
	 		 	     Companion Diagnostics
	  	 	29	  
				
	 Section 3.5
	 		 	     Records; Tech Transfer
	  	 	30	  
			
	 ARTICLE IV
	 	 MANUFACTURE AND SUPPLY
	  	 	31	  
				
	 Section 4.1
	 		 	     Pre-Clinical, Clinical and Commercial Supply
	  	 	31	  


  
 - i - 









									
	 Section 4.2
	 		 	     Third Party Manufacturers
	  	 	32	  
				
	 Section 4.3
	 		 	     Transfer of Manufacturing Responsibility
	  	 	32	  
				
	 Section 4.4
	 		 	     Manufacturing Efforts
	  	 	32	  
			
	 ARTICLE V
	 	 REGULATORY MATTERS
	  	 	33	  
				
	 Section 5.1
	 		 	     Lead Responsibility for Regulatory Interactions
	  	 	33	  
				
	 Section 5.2
	 		 	     Participation Rights
	  	 	34	  
				
	 Section 5.3
	 		 	     Global Safety Database; Pharmacovigilance Agreement
	  	 	34	  
				
	 Section 5.4
	 		 	     Recalls, Market Withdrawals or Corrective Actions
	  	 	35	  
			
	 ARTICLE VI
	 	 COMMERCIALIZATION
	  	 	35	  
				
	 Section 6.1
	 		 	     Commercialization Responsibilities for Licensed Products
	  	 	35	  
				
	 Section 6.2
	 		 	     Commercialization Plan
	  	 	36	  
				
	 Section 6.3
	 		 	     Field-Based Marketing Activities
	  	 	37	  
				
	 Section 6.4
	 		 	     Trademarks
	  	 	38	  
			
	 ARTICLE VII
	 	 DILIGENCE
	  	 	39	  
				
	 Section 7.1
	 		 	     Collaboration Activities
	  	 	39	  
				
	 Section 7.2
	 		 	     Diligence Obligations
	  	 	39	  
				
	 Section 7.3
	 		 	     Day-to-Day Responsibility
	  	 	40	  
			
	 ARTICLE VIII
	 	 GRANT OF RIGHTS; EXCLUSIVITY
	  	 	40	  
				
	 Section 8.1
	 		 	     License Grants
	  	 	40	  
				
	 Section 8.2
	 		 	     Sublicense Rights
	  	 	40	  
				
	 Section 8.3
	 		 	     Sublicense Requirements
	  	 	41	  
				
	 Section 8.4
	 		 	     Affiliates and Third Party Contractors
	  	 	42	  
				
	 Section 8.5
	 		 	     Existing Third Party Agreement
	  	 	42	  
				
	 Section 8.6
	 		 	     Exclusivity
	  	 	45	  
				
	 Section 8.7
	 		 	     Retained Rights
	  	 	46	  
				
	 Section 8.8
	 		 	     Section 365(n) of the Bankruptcy Code
	  	 	46	  


  
 - ii - 









									
	 ARTICLE IX
	 	 FINANCIAL PROVISIONS
	  	 	46	  
				
	 Section 9.1
	 		 	     Initial Payment
	  	 	46	  
				
	 Section 9.2
	 		 	     Development Costs
	  	 	47	  
				
	 Section 9.3
	 		 	     Milestone Payments
	  	 	48	  
				
	 Section 9.4
	 		 	     US Territory Profit or Loss
	  	 	49	  
				
	 Section 9.5
	 		 	     Royalty Payments Following Agios Opt-Out
	  	 	50	  
				
	 Section 9.6
	 		 	     Third Party Payments
	  	 	51	  
				
	 Section 9.7
	 		 	     Financial Records
	  	 	52	  
				
	 Section 9.8
	 		 	     Audits
	  	 	53	  
				
	 Section 9.9
	 		 	     Tax Matters
	  	 	54	  
				
	 Section 9.10
	 		 	     Currency Exchange
	  	 	55	  
				
	 Section 9.11
	 		 	     Late Payments
	  	 	55	  
				
	 Section 9.12
	 		 	     Payment by Affiliates
	  	 	55	  
			
	 ARTICLE X
	 	 INTELLECTUAL PROPERTY OWNERSHIP, PROTECTION AND RELATED MATTERS
	  	 	56	  
				
	 Section 10.1
	 		 	     Ownership of Inventions
	  	 	56	  
				
	 Section 10.2
	 		 	     Prosecution of Patent Rights
	  	 	57	  
				
	 Section 10.3
	 		 	     Third Party Infringement of Agios Patent Rights and Collaboration Patent Rights
	  	 	60	  
				
	 Section 10.4
	 		 	     Claimed Infringement; Claimed Invalidity
	  	 	63	  
				
	 Section 10.5
	 		 	     Patent Term Extensions
	  	 	64	  
				
	 Section 10.6
	 		 	     Patent Marking
	  	 	64	  
				
	 Section 10.7
	 		 	     CREATE Act Application
	  	 	64	  
				
	 Section 10.8
	 		 	     Challenges to Patent Rights
	  	 	65	  
				
	 Section 10.9
	 		 	     Celgene Intellectual Property
	  	 	66	  


  
 - iii - 









									
	 ARTICLE XI
	 	 CONFIDENTIALITY
	  	 	66	  
				
	 Section 11.1
	 		 	     Confidential Information
	  	 	66	  
				
	 Section 11.2
	 		 	     Permitted Disclosure
	  	 	66	  
				
	 Section 11.3
	 		 	     Publicity; Terms of this Agreement; Non-Use of Names
	  	 	67	  
				
	 Section 11.4
	 		 	     Publications
	  	 	69	  
				
	 Section 11.5
	 		 	     Term
	  	 	70	  
				
	 Section 11.6
	 		 	     Return of Confidential Information
	  	 	70	  
			
	 ARTICLE XII
	 	 REPRESENTATIONS AND WARRANTIES
	  	 	71	  
				
	 Section 12.1
	 		 	     Mutual Representations
	  	 	71	  
				
	 Section 12.2
	 		 	     Additional Agios Representations
	  	 	72	  
				
	 Section 12.3
	 		 	     Additional Celgene Representations
	  	 	73	  
				
	 Section 12.4
	 		 	     Employee Obligations
	  	 	73	  
				
	 Section 12.5
	 		 	     No Warranties
	  	 	73	  
			
	 ARTICLE XIII
	 	 INDEMNIFICATION; PRODUCT LIABILITIES
	  	 	74	  
				
	 Section 13.1
	 		 	     By Celgene
	  	 	74	  
				
	 Section 13.2
	 		 	     By Agios
	  	 	74	  
				
	 Section 13.3
	 		 	     Product Liability Costs
	  	 	75	  
				
	 Section 13.4
	 		 	     Conduct of Product Liability Claims
	  	 	75	  
				
	 Section 13.5
	 		 	     Limitation of Liability
	  	 	76	  
				
	 Section 13.6
	 		 	     Insurance
	  	 	76	  
			
	 ARTICLE XIV
	 	 TERM AND TERMINATION
	  	 	77	  
				
	 Section 14.1
	 		 	     Term
	  	 	77	  
				
	 Section 14.2
	 		 	     Termination
	  	 	77	  
				
	 Section 14.3
	 		 	     Effects Of Termination
	  	 	78	  


  
 - iv - 









									
	 ARTICLE XV
	 	 MISCELLANEOUS
	  	 	83	  
				
	 Section 15.1
	 		 	     Dispute Resolution
	  	 	83	  
				
	 Section 15.2
	 		 	     Submission to Court for Resolution
	  	 	84	  
				
	 Section 15.3
	 		 	     Governing Law
	  	 	84	  
				
	 Section 15.4
	 		 	     Assignment
	  	 	84	  
				
	 Section 15.5
	 		 	     Certain Additional Matters Relating to Change of Control of a Party
	  	 	85	  
				
	 Section 15.6
	 		 	     Force Majeure
	  	 	89	  
				
	 Section 15.7
	 		 	     Notices
	  	 	89	  
				
	 Section 15.8
	 		 	     Waiver
	  	 	90	  
				
	 Section 15.9
	 		 	     Severability
	  	 	90	  
				
	 Section 15.10
	 		 	     Entire Agreement
	  	 	90	  
				
	 Section 15.11
	 		 	     Modification
	  	 	91	  
				
	 Section 15.12
	 		 	     Independent Contractors; No Intended Third Party Beneficiaries
	  	 	91	  
				
	 Section 15.13
	 		 	     Interpretation; Construction
	  	 	91	  
				
	 Section 15.14
	 		 	     Performance by Affiliates
	  	 	91	  
				
	 Section 15.15
	 		 	     Counterparts
	  	 	91	  
				
	 Section 15.16
	 		 	     Certain U.S. Federal Income Tax Treatment
	  	 	91	  
				
	 Section 15.17
	 		 	     HSR Clearance; Cooperation
	  	 	92	  


  
 - v - 








 Exhibits 
  

			
	 Exhibit A
	  	AGI-23088
		
	 Exhibit B
	  	Agios Patent Rights and Agios Collaboration Patent Rights
		
	 Exhibit C
	  	[Exhibit no longer used.]
		
	 Exhibit D
	  	Existing Third Party Agreement
		
	 Exhibit E
	  	Certain Financial Definitions
		
	 Exhibit F
	  	Countries for Filing Agios Patent Rights and Collaboration Patent Rights
		
	 Exhibit G
	  	Press Release
		
	 Exhibit H
	  	JSC, JDC and JPC Appointments
		
	 Exhibit I

	  	Partnership Tax Matters


  
 - vi - 








 COLLABORATION AND LICENSE AGREEMENT 

(AGI-23088 for the US Territory) 

This Collaboration and License Agreement (this “Agreement”) is entered into as of April 27, 2015 (the “Effective
Date”), by and between Agios Pharmaceuticals, Inc., a corporation organized and existing under the laws of the State of Delaware and having its principal office at 38 Sidney St., 2nd Floor, Cambridge, MA 02139-4169
(“Agios”), and Celgene Corporation, a corporation organized and existing under the laws of the State of Delaware and having its principal office at 86 Morris Avenue, Summit, NJ 07901 (“Celgene”). 

INTRODUCTION 
  

	1.	Agios and Celgene are parties to the Discovery and Development Collaboration and License Agreement, dated as of April 14, 2010, as amended (the “2010 Agreement”). 


 

	2.	Pursuant to the 2010 Agreement, Agios has discovered and is developing a compound referred to as AGI-23088 and as AG-881, which the Parties believe to be a potent inhibitor of IDH1 and IDH2 mutants and wild type, with
the potential for penetration of the blood brain barrier. 

  

	3.	The Parties have agreed that the further Development and Commercialization of AGI-23088, which has potential overlaps with other programs currently being undertaken pursuant to the 2010 Agreement, should be conducted
pursuant to the terms of this Agreement between the Parties for the US Territory and another agreement between Celgene International II Sarl (“CIS II”) and Agios International Sarl (“AIS”) for the ROW Territory
(“AGI-23088 ROW Agreement”) and that all further such activities related to AGI-23088 should cease under the 2010 Agreement. 


NOW, THEREFORE, in consideration of the respective representations, warranties, covenants and agreements contained herein, and for other
valuable consideration, the receipt and adequacy of which are hereby acknowledged, Agios and Celgene hereby agree as follows: 
 Article I

 Definitions 
 When
used in this Agreement, each of the following terms shall have the meanings set forth in this Article I: 
 Section 1.1
“Affiliate” means, as to any Person, any other Person that, directly or indirectly through one or more intermediaries, controls, is controlled by or is under common control with such Person, as the case may be, for so long as such
control exists. As used in this Section 1.1, “control” means: (a) to possess, directly or indirectly, the power to direct the management and policies of a Person, whether through ownership of voting securities or by
contract relating to voting rights or corporate governance; or (b) direct or indirect beneficial ownership of at least fifty percent (50%) (or such lesser percentage that is the maximum allowed to be owned by a foreign Person in a
particular jurisdiction) of the voting share capital in a Person. 







 Section 1.2 “AGI-23088” means the compound described on Exhibit A to
this Agreement. Such compound may also be referred to from time to time as AG-881. 
 Section 1.3 “Agios Collaboration
Intellectual Property,” “Agios Collaboration Know-How” and “Agios Collaboration Patent Rights” means, respectively, the Collaboration Intellectual Property Controlled by Agios or AIS, the Collaboration
Know-How Controlled by Agios or AIS, and the Collaboration Patent Rights Controlled by Agios or AIS. 
 Section 1.4 “Agios
Intellectual Property” means Agios Know-How and Agios Patent Rights, collectively. 
 Section 1.5 “Agios
Know-How” means any Know-How that is (a) Controlled by Agios or AIS as of the Effective Date or during the Term, and (b) necessary or useful for the Development, Manufacture and/or Commercialization of the Licensed Products, but
excluding Collaboration Know-How. 
 Section 1.6 “Agios Patent Rights” means any Patent Rights that (a) are
Controlled by Agios or AIS as of the Effective Date or during the Term, and (b) Cover, or are otherwise necessary or useful for the Development, Manufacture and/or Commercialization of, the Licensed Products (including the composition of
matter, manufacture or any use thereof); but excluding Collaboration Patent Rights. Agios Patent Rights as of the Effective Date are as set forth on Exhibit B to this Agreement. 

Section 1.7 “Business Day” means a day other than a Saturday or Sunday or federal holiday in Cambridge, Massachusetts or
Summit, New Jersey. 
 Section 1.8 “Calendar Quarter” means a calendar quarter ending on the last day of March, June,
September or December; provided, however, that the first Calendar Quarter shall begin on the Effective Date and end on the last day of June following the Effective Date. 

Section 1.9 “Calendar Year” means a period of time commencing on January 1 and ending on the following
December 31; provided, however, that the first Calendar Year shall begin on the Effective Date and end on December 31, 2015. 

Section 1.10 “Celgene Collaboration Intellectual Property”, “Celgene Collaboration Know-How” and
“Celgene Collaboration Patent Rights” means, respectively, the Collaboration Intellectual Property Controlled by Celgene or CIS II, the Collaboration Know-How Controlled by Celgene or CIS II and the Collaboration Patent Rights
Controlled by Celgene or CIS II. 
 Section 1.11 “Celgene Intellectual Property” means Celgene Know-How and Celgene
Patent Rights, collectively. 
 Section 1.12 “Celgene Know-How” means any Know-How that is (a) Controlled by
Celgene or CIS II as of the Effective Date or during the Term; (b) necessary for the Development, Manufacture and/or Commercialization of the Licensed Products; and (c) contributed by Celgene or CIS II, in Celgene’s or CIS II’s
sole discretion, to the Collaboration, as evidenced by written notice from Celgene or CIS II to Agios; but excluding Collaboration Know-How. 

  
 - 2 - 








 Section 1.13 “Celgene Patent Rights” means any Patent Rights that
(a) are Controlled by Celgene or CIS II as of the Effective Date or during the Term; (b) Cover the Licensed Products (including the composition of matter, manufacture or any use thereof); and (c) are contributed by Celgene or CIS II,
in Celgene’s or CIS II’s sole discretion, to the Collaboration, as evidenced by written notice from Celgene or CIS II to Agios; but excluding Collaboration Patent Rights. 

Section 1.14 “Clinical Trial” means a Phase I Study, a Phase II Study, a Phase III Study, a Phase IV Study or a
combination of any of the foregoing studies. 
 Section 1.15 “Code” means the United States Internal Revenue Code of
1986, as amended. 
 Section 1.16 “Collaboration” means the activities performed or to be performed by a Party or
Parties, as the case may be, relating to the Development, Manufacturing and Commercialization of the Licensed Products under this Agreement, the AGI-23088 ROW Agreement, and the activities performed by a Party or the Parties relating to the
Development and Manufacturing of AGI-23088 under the 2010 Agreement before the Effective Date, collectively. 

Section 1.17 “Collaboration Intellectual Property” means Collaboration Know-How and Collaboration Patent Rights,
collectively. 
 Section 1.18 “Collaboration Know-How” means any Know-How or interest therein that was, before the
Effective Date, or is, on or after the Effective Date, developed or generated, either solely by or on behalf of Celgene, CIS II, Agios or AIS or jointly by or on behalf of any of such Persons in the conduct of the Collaboration, including Joint
Inventions. 
 Section 1.19 “Collaboration Patent Rights” means any Patent Rights or interest therein that was, before
the Effective Date, or is, on or after the Effective Date, Controlled solely by Celgene, CIS II, Agios or AIS or Controlled jointly by any of such Persons and that Cover Collaboration Know-How, including Joint Patents and any such Patent Rights
filed before or after the Effective Date. 
 Section 1.20 “Commercialization” or “Commercialize”
means any activities directed to using, marketing, promoting, distributing, importing, offering to sell, and/or selling a product, after or in expectation of receipt of Regulatory Approval for such product (but excluding Development and any Phase IV
Studies). 
 Section 1.21 “Commercially Reasonable Efforts” means, with respect to the performing Party, the carrying
out of obligations of such Party in a diligent, expeditious and sustained manner, including the allocation of a commercially reasonable level of personnel and financial resources, but in no event less than such level of resources that an established
biopharmaceutical company typically devotes to products of similar market potential at a similar stage in its development or product life, taking into account scientific and commercial factors, including commercial Manufacturing, issues of safety
and efficacy, product profit, difficulty in developing or manufacturing the Licensed Products, competitiveness of alternative Third Party products in the marketplace, the patent or other proprietary position of the Licensed Products, the regulatory
requirements involved and the potential profitability for the performing Party of the Licensed Products, marketed or to be marketed. 

  
 - 3 - 








 Section 1.22 “Companion Diagnostic” means a biomarker or diagnostic test
that may be used with a Licensed Product, or may be developed by the Parties pursuant to Section 3.4, to generate a result for the purposes of diagnosing a disease or condition, or to facilitate the application of the Licensed Product that is
used in the cure, mitigation, treatment, or prevention of disease, including a biomarker or diagnostic test used to diagnose the likelihood that a specific patient will contract a certain type of cancer or to predict which patients are suitable
candidates for a specific form of chemotherapy. 
 Section 1.23 “Compound” means AGI-23088 and any polymorph,
isotopologue, stereoisomer, prodrug, solvate, co-crystal or salt of AGI-23088. 
 Section 1.24 “Confidential
Information” means (a) all confidential or proprietary information relating to the Collaboration, and (b) all other confidential or proprietary documents, technology, Know-How or other information (whether or not patentable)
actually disclosed by one Party to the other pursuant to this Agreement, the AGI-23088 ROW Agreement or the 2010 Agreement relating to the Licensed Products and all proprietary biological materials of a Party. 

Section 1.25 “Control” or “Controlled” means, with respect to any (a) Know-How or other
information or materials, (b) compound, or (c) intellectual property right, the possession (whether by license (other than a license granted under this Agreement) or ownership) by a Party of the ability to grant to the other Party access
and/or a license, as provided herein, without violating the terms of any agreement with any Third Party existing as of the Effective Date or thereafter during the Term. 

Section 1.26 “Core Patent Rights” means Patent Rights comprising [**] claims. 

Section 1.27 “Cover,” “Covering” or “Covered” means that, with respect to a product or
technology, but for a Person’s ownership of Patent Rights or a license granted to a Person under a Valid Claim included in the Patent Rights under which such license is granted, the Development, Manufacture, Commercialization and/or other use
of such product or practice of such technology by such Person would infringe any Valid Claim of any patent included in such Patent Rights or, with respect to a Valid Claim included in any patent application, would infringe such Valid Claim if such
patent application were to issue as a patent. 
 Section 1.28 “Data” means any and all research data, results,
pharmacology data, medicinal chemistry data, preclinical data, market research, clinical data (including investigator reports (both preliminary and final), statistical analysis, expert opinions and reports, safety and other electronic databases), in
any and all forms, including files, reports, raw data, source data (including patient medical records and original patient report forms, but excluding patient-specific data to the extent required by applicable Laws) and the like, in each case
directed to, or used in, the Development, Manufacture or Commercialization of the Licensed Products. 
 Section 1.29
“Develop” or “Development” means research, preclinical, non-clinical and clinical development activities, including activities relating to assays, test method development and stability testing, toxicology,
pharmacology, formulation, quality assurance/quality control 

  
 - 4 - 








 
development, Clinical Trials (including any Phase IV Study), technology transfer, statistical analysis, process development and scale-up, pharmacokinetic studies, data collection and management,
report writing, and other pre-Regulatory Approval activities. 
 Section 1.30 “Development Plan” means a development
plan and related budget approved by the JSC by Mutual Consent after the Effective Date, as amended from time to time by the JSC by Mutual Consent. 

Section 1.31 “Executive Officers” means Celgene’s Chief Executive Officer (or the officer or employee of Celgene
then serving in a substantially equivalent capacity) or his designee and Agios’ Chief Executive Officer (or the officer or employee of Agios then serving in a substantially equivalent capacity) or his designee; provided that any
such designee must have decision-making authority on behalf of the applicable Party. 
 Section 1.32 “Existing Third Party
Agreement” means any agreement listed on Exhibit D to this Agreement. 
 Section 1.33 “FDA” means
the United States Food and Drug Administration, or any successor agency thereof. 
 Section 1.34 “FDCA” means the
United States Federal Food, Drug, and Cosmetic Act, and the regulations promulgated thereunder, each as amended from time to time. 

Section 1.35 “Field” means the treatment, control, mitigation, prevention or cure or diagnosis of any Indications. 

Section 1.36 “First Commercial Sale” means the first commercial sale of a Licensed Product by a Party, its Affiliates,
distributors and/or agents in a country in an arms’ length transaction to a Third Party following receipt of applicable Regulatory Approval of such product in such country. Sales for test marketing or clinical trial purposes shall not
constitute a First Commercial Sale. 
 Section 1.37 “Generic Competition” means, with respect to a Licensed Product in
a given country in a given Calendar Year, that, during such Calendar Year [**] Generic Products shall be commercially available in such country. 

Section 1.38 “Generic Product” means, as to a Licensed Product, any product (including a “generic product”
approved by way of an Abbreviated New Drug Application by the FDA (or equivalent regulatory mechanism for another Regulatory Authority), “biogeneric,” “follow-on biologic,” “follow-on biological product,”
“follow-on protein product,” “similar biological medicinal product,” or “biosimilar product”) that, in each case, (a) is sold by a Third Party that is not a sublicensee of the royalty-paying Party or any of its
Affiliates and that has not otherwise been authorized by the royalty-paying Party or any of its Affiliates under a Regulatory Approval granted by a Regulatory Authority to such Third Party that is based upon or relies upon the Regulatory Approval
granted by such Regulatory Authority for such Licensed Product; and (b) in the United States, is “therapeutically equivalent,” “comparable,” “biosimilar,” or “interchangeable,” as evaluated by the FDA,
applying the definition of “therapeutically equivalent” set forth in the preface to the then-current edition of the FDA publication “Approved 

  
 - 5 - 








 
Drug Products With Therapeutic Equivalence Evaluations” or any other definitions set forth in the U.S. Code, FDA regulations, or other source of U.S. Law and, outside the United States,
meets such equivalent determination by the applicable Regulatory Authorities (including a determination that the product is “comparable,” “interchangeable,” “bioequivalent,” or “biosimilar” with respect to the
Licensed Product), in each case, as is necessary to permit a pharmacist or other individual authorized to dispense pharmaceuticals under Law to substitute one product for another product in the absence of specific instruction from a physician or
other authorized prescriber under Law. 
 Section 1.39 “IDH1” means (alias PICD, IDPC; UniProt identifier O75874) the
persoxisomal/cytosolic form of isocitrate dehydrogenase that catalyzes the NADP+ dependent conversion of isocitrate to alpha-ketoglutarate. 

Section 1.40 “IDH2” means (alias ICD-M, IDPM; UniProt identifier P48735) the mitochondrial form of isocitrate
dehydrogenase that catalyzes the NADP+ dependent conversion of isocitrate to alpha-ketoglutarate. 
 Section 1.41
“IND” means any Investigational New Drug application filed with the FDA pursuant to Part 312 of Title 21 of the U.S. Code of Federal Regulations, including any supplements or amendments thereto. References herein to IND shall
include, to the extent applicable, any comparable filing(s) outside the United States. 
 Section 1.42 “IND Acceptance
Date” means thirty (30) days following the filing of an IND with the FDA; provided that the FDA has not provided any communication indicating that the conduct of clinical activities described in such IND may not begin
within thirty (30) days after such filing. In the event that any such communication is provided by the FDA, “IND Acceptance Date” means the date that the Parties are permitted by the FDA to begin clinical activities. If the Parties
both agree, “IND Acceptance Date” means the date, following filing of an IND with a Regulatory Authority (other than the FDA), that Agios receives a written communication from such Regulatory Authority pursuant to which the conduct of
clinical activities described in the appropriate submissions is permitted to begin. 
 Section 1.43 “Indication” means
any human disease, condition or syndrome, or sign or symptom of, or associated with, a human disease or condition. 
 Section 1.44
“Know-How” means any tangible or intangible trade secrets, know-how, expertise, discoveries, inventions, information, data or materials, including ideas, concepts, formulas, methods, procedures, designs, technologies, compositions,
plans, applications, technical data, assays, manufacturing information or data, samples, chemical and biological materials and all derivatives, modifications and improvements thereof. 

Section 1.45 “Law” means any law, statute, rule, regulation, ordinance or other pronouncement having the effect of law,
of any federal, national, multinational, state, provincial, county, city or other political subdivision, as from time to time enacted, repealed or amended, including good clinical practices and adverse event reporting requirements, guidance from the
International Conference on Harmonization or other generally accepted conventions, the FDCA and similar laws and regulations in countries outside the United States, and all other rules, regulations and requirements of the FDA and other applicable
Regulatory Authorities. 

  
 - 6 - 








 Section 1.46 “Licensed Products” means (a) a Compound, and
(b) any product that contains a Compound as an active ingredient. 
 Section 1.47 “Licensee Partner” means any
Third Party to whom a Party or any of its Affiliates grants a sublicense or license with respect to the Development, Manufacture or Commercialization of Licensed Products in the Field in the US Territory under the rights to Agios Intellectual
Property, Celgene Intellectual Property or Collaboration Intellectual Property, as the case may be, granted to such Party or Affiliate hereunder, in each case excluding (a) any Person that is granted a sublicense in accordance with
Section 8.2(a), and (b) wholesale distributors or any other Third Party that purchases Licensed Product in an arm’s-length transaction, where such Third Party does not have a sublicense to Develop, Manufacture or Commercialize the
Licensed Product except for a limited sublicense to the extent required to enable such Third Party to perform final packaging for such Licensed Product for local distribution. 

Section 1.48 “Major European Countries” means France, Germany, Italy, Spain and the United Kingdom. 

Section 1.49 “Major Market” means each of the United States of America, Japan, and the Major European Countries. 

Section 1.50 “Manufacture” or “Manufacturing” means, as applicable, all activities associated with the
production, manufacture, processing, filling, packaging, labeling, shipping, and storage of a drug substance or drug product, and/or any components thereof, including process and formulation development, process validation, stability testing,
manufacturing scale up, preclinical, clinical and commercial manufacture and analytical methods development and validation, product characterization, quality assurance and quality control development, testing and release. 

Section 1.51 “Manufacturing Technology” means copies of all Celgene Know-How, Agios Know-How or Collaboration Know-How,
as applicable, which are necessary or useful for Manufacturing preclinical, clinical and/or commercial supply, as applicable, of the Licensed Products, including specifications, assays, batch records, quality control data, and transportation and
storage requirements. 
 Section 1.52 “Mutual Consent” means with respect to any matter specified as requiring
“Mutual Consent”, that each Party must consent in writing to the action to be taken (or not taken), or if the matter is one referred to the JSC, that the JSC must approve the action to be taken (or not taken) by unanimous vote, with each
Party (or its voting member of the JSC), in its/his/her sole discretion, being entitled to withhold its/his/her consent to or approval of the matter; provided, however, that a Party may take any such action as required by
applicable Law or order of any governmental authority in the absence of the consent of the other Party or the approval of the JSC, as applicable. 

  
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 Section 1.53 “NDA” means an application submitted to a Regulatory Authority
for the marketing approval of a Licensed Product, including (a) a New Drug Application, Product License Application or Biologics License Application filed with FDA or any successor applications or procedures, (b) a foreign equivalent of a
U.S. New Drug Application, Product License Application or Biologics License Application or any successor applications or procedures, and (c) all supplements and amendments that may be filed with respect to the foregoing. 

Section 1.54 “Party” means Agios or Celgene; “Parties” means Agios and Celgene. 

Section 1.55 “Patent Rights” means (a) patents and patent applications anywhere in the world, (b) all
divisionals, continuations, continuations in-part thereof or any other patent application claiming priority, or entitled to claim priority, directly or indirectly to (i) any such patents or patent applications or (ii) any patent or patent
application from which such patents or patent applications claim, or is entitled to claim, direct or indirect priority, and (c) all patents issuing on any of the foregoing anywhere in the world, together with all registrations, reissues,
re-examinations, patents of addition, renewals, supplemental protection certificates, or extensions of any of the foregoing anywhere in the world. 

Section 1.56 “Person” means any corporation, limited or general partnership, limited liability company, joint venture,
trust, unincorporated association, governmental body, authority, bureau or agency, any other entity or body, or an individual. 

Section 1.57 “Phase I Study” means a human clinical trial of a product, the principal purpose of which is a preliminary
determination of safety, tolerability and pharmacokinetics in study subjects where potential pharmacological activity may be determined or similar clinical study prescribed by the Regulatory Authorities, from time to time, pursuant to applicable Law
or otherwise, including for example the trials referred to in 21 C.F.R. §312.21(a), as amended (or the non-United States equivalent thereof). 

Section 1.58 “Phase II Study” means a human clinical trial of a product, the principal purpose of which is a preliminary
determination of safety and efficacy or appropriate dosage ranges in the target patient population or a similar clinical study prescribed by the Regulatory Authorities, from time to time, pursuant to applicable Law or otherwise, including for
example the trials referred to in 21 C.F.R. §312.21(b), as amended (or the non-United States equivalent thereof). 
 Section 1.59
“Phase III Study” means a pivotal human clinical trial of a product, the principal purpose of which is to gain evidence with statistical significance of the efficacy of a product in a target population, to obtain expanded evidence
of safety for such product that is needed to evaluate the overall benefit-risk relationship of such product, and to provide an adequate basis to determine warnings, precautions, and adverse reactions that are associated with such product in the
dosage range to be prescribed, which trial is intended to support or maintain Regulatory Approval for such product, including all tests and studies prescribed by the applicable Regulatory Authority, from time to time, pursuant to applicable Law or
otherwise, including for example the trials referred to in 21 C.F.R. §312.21(c), as amended (or the non-United States equivalent thereof). 

  
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 Section 1.60 “Phase IV Study” means a human clinical trial of a product
which is (a) conducted to satisfy a requirement of a Regulatory Authority in order to maintain a Regulatory Approval or (b) conducted voluntarily after Regulatory Approval of the product has been obtained from an appropriate Regulatory
Authority for enhancing marketing or scientific knowledge of an approved Indication. 
 Section 1.61 “Prosecution” or
“Prosecute” means the filing, preparation, prosecution and maintenance of Patent Rights, including any and all pre-grant and post-grant ex-parte or inter partes proceedings before any patent authority, such as interferences,
reissue proceedings, reexaminations, oppositions or other challenges to the patentability or validity of any Patent Rights not initiated through a court or other tribunal that determines infringement. 

Section 1.62 “Publication” means any publication in a scientific journal or other scientific periodical, publication in
any government clinical trial reporting website, any abstract to be presented to any scientific audience, any presentation at any scientific conference, including slides and texts of oral or other public presentations, any other public presentation
directed to a scientific audience that pertains to any Licensed Product, the use of any Licensed Product, or the data or result from any work under the Collaboration. 

Section 1.63 “Regulatory Approval” means all approvals of the applicable Regulatory Authority necessary for the
commercial marketing and sale of a product for a particular Indication in a country. 
 Section 1.64 “Regulatory
Authority” means a federal, national, multinational, state, provincial or local regulatory agency, department, bureau or other governmental entity with authority over the testing, manufacture, use, storage, import, promotion, marketing or
sale of a product in a country or territory. 
 Section 1.65 “Regulatory Documentation” means, with respect to the
Collaboration, all INDs, NDAs and other regulatory applications submitted to any Regulatory Authority, Regulatory Approvals, pre-clinical and clinical data and information, regulatory materials, drug dossiers, master files (including Drug Master
Files, as defined in 21 C.F.R. 314.420 and any non-United States equivalents), and any other data, reports, records, regulatory correspondence and other materials relating to Development or Regulatory Approval of the Licensed Products, or required
to Manufacture, distribute or sell the Licensed Products, including any information that relates to pharmacology, toxicology, chemistry, Manufacturing and controls data, batch records, safety and efficacy, and any safety database. 

Section 1.66 “Regulatory Exclusivity” means, with respect to a Licensed Product in a country, that the Licensed Product
has been granted marketing exclusivity afforded approved drug products, or approved biological products if applicable, pursuant to (a) Sections 505(c), 505(j), and 505A of the FDCA, and the regulations promulgated thereunder, as amended from
time to time, or similar laws enacted to apply to biological products, and the regulations promulgated thereunder, as amended from time to time, or their equivalent in a country other than the United States, (b) the orphan drug exclusivity
afforded approved drugs designated for rare diseases or conditions under Sections 526 and 527 of the FDCA, and the regulations promulgated thereunder, as amended from time to time, or its equivalent in a country other than the United States, or
(c) any future Law. 

  
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 Section 1.67 “Right of Reference or Use” means a “Right of Reference
or Use” as that term is defined in 21 C.F.R. §314.3(b), and any non-United States equivalents. 
 Section 1.68 “ROW
Territory” means all countries in the world other than the US Territory. 
 Section 1.69 “Sole” means, with
respect to the license of any Patent Rights or Know-How, that such license is an exclusive license, except for the rights reserved by the licensor for itself and its Affiliates (a) to continue to practice the subject Patent Rights and Know-How
and (b) to license or sublicense, as applicable, the subject Patent Rights and Know to Third Parties as reasonably necessary for such licensor or its Affiliates to exercise their rights or fulfill their obligations under the Collaboration. 

Section 1.70 “Target” means IDH1 or IDH2. 

Section 1.71 “Territory” means the US Territory and the ROW Territory. 

Section 1.72 “Third Party” means any Person other than Agios or Celgene or each Party’s respective Affiliates. 

Section 1.73 “Third Party Agreement” means (a) the Existing Third Party Agreement and (b) any other Third
Party agreements which either Party may enter into, during the Term in accordance with the terms of this Agreement, to acquire or license Third Party Patent Rights or Know-How that are necessary or useful for the Development, Manufacture and/or
Commercialization of the Licensed Products. 
 Section 1.74 “Third Party Rights” means, with respect to a Party, any
rights of, and any limitations, restrictions or obligations imposed by, Third Parties pursuant to any Third Party Agreements. 

Section 1.75 “US Territory” means the United States of America, including its territories, possessions and Puerto Rico.

 Section 1.76 “Valid Claim” means (a) a claim of any issued, unexpired patent that has not been revoked or held
unenforceable or invalid by a decision of a court or governmental agency of competent jurisdiction from which no appeal can be taken, or with respect to which an appeal is not taken within the time allowed for appeal, and that has not been
disclaimed or admitted to be invalid or unenforceable through reissue, disclaimer or otherwise, or (b) a patent application or subject matter of a claim thereof filed by a Person in good faith that has not been cancelled, withdrawn or
abandoned, nor been pending for more than [**] years from the earliest filing date to which such patent application or claim is entitled. 

  
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 Section 1.77 Additional Definitions. Each of the following definitions is set forth
in the section of this Agreement indicated below: 
  

			
	 DEFINITION
	  	 SECTION

		
	2010 Agreement	  	Introduction
	AAA	  	15.1(b)
	Accounting Standards	  	Exhibit E
	Acquired Party	  	15.4(b)
	Acquired Party Activity	  	15.4(c)
	Acquired Third Party	  	15.4(c)
	Acquirer	  	15.4(b)
	Acquisition	  	15.4(b)
	Additional Development Activities	  	3.3
	Additional Development Opt-In Date	  	3.3(e)(i)
	Additional Development Opt-In Notice	  	3.3(e)
	Additional Development Proposal	  	3.3(a)
	Additional Development Party	  	3.3(c)
	Additional Revenue	  	Exhibit E
	Advertising and Market Research Expenses	  	Exhibit E
	AGI-23088 ROW Agreement	  	Recitals
	Agios	  	Preamble
	Agios Clinical-Scale Manufacturing Responsibilities	  	4.1(a)
	Agios Commercial-Scale Manufacturing Responsibilities	  	4.1(a)
	Agios Indemnified Parties	  	13.1(a)
	Agios Opt-Out Notice	  	2.12(a)
	Agios Opt-Out Date	  	2.12(a)
	Agreement	  	Preamble
	AIS	  	Recitals
	Alliance Manager	  	2.6
	Annual Net Sales	  	Exhibit E
	Arbitrable Matters	  	15.1(b)
	Audit Team	  	9.8(a)
	Audit Rights Holder	  	9.8(f)
	Auditee	  	9.8(f)
	Bankruptcy Code	  	8.8
	Breaching Party	  	14.2(b)(i)
	CA 23088 US Partnership	  	15.16
	Celgene	  	Preamble
	Celgene Controlled Agios Patent Rights	  	10.2(b)
	Celgene Indemnified Parties	  	13.2(a)
	Celgene Manufacturing Responsibilities	  	4.1(c)
	Challenge	  	10.8(a)
	Change of Control	  	15.5(c)
	CIS II	  	Recitals
	Combination Product	  	Exhibit E
	Commercialization Expenses	  	Exhibit E
	Commercialization Budget	  	6.2(a)(i)
	Commercialization Plan	  	6.2(a)(i)
	Committee	  	2.1(a)


  
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	 DEFINITION
	  	 SECTION

		
	Competitive Infringement	  	10.3(b)
	Cooperating Party	  	11.3(b)(iii)
	CPI	  	Exhibit E
	CREATE Act Patent	  	10.7
	Development Budget	  	3.1(a)
	Development Costs	  	Exhibit E
	Disclosing Party	  	11.1
	Dispute	  	15.1(a)
	Distribution Costs	  	Exhibit E
	DOJ	  	15.17(c)(i)
	[**] Agreement	  	Exhibit D
	Earlier Patent	  	10.7
	Effective Date	  	Preamble
	Excess Amounts	  	9.2(b)
	Expert	  	15.1(b)(i)
	Finance Working Group	  	2.1(a)
	Financial Exhibit	  	2.9(b)
	FTC	  	15.17(c)(ii)
	FTE	  	Exhibit E
	FTE Costs	  	Exhibit E
	FTE Rate	  	Exhibit E
	Global Safety Database	  	5.3
	Health Care Reform Fees	  	Exhibit E
	[**]	  	15.12
	HSR Act	  	15.17(c)(iii)
	Initial Enforcement Party	  	10.3(b)
	Invalidity Claim	  	10.4(b)
	JCC	  	2.1(a)
	JDC	  	2.1(a)
	Joint Inventions	  	10.1(c)
	Joint Patents	  	10.1(c)
	JPC	  	2.1(a)
	JPC Designee	  	2.8(e)
	JSC	  	2.1(a)
	Manufacturing Costs	  	Exhibit E
	Manufacturing Scale-Up Costs	  	Exhibit E
	Marketing Activities	  	6.3(a)
	Marketing Expenses	  	Exhibit E
	Marketing Management Expenses	  	Exhibit E
	Medical Education Expenses	  	Exhibit E
	Net Sales	  	Exhibit E
	Non-Additional Development Party	  	3.3(c)
	Non-Breaching Party	  	14.2(b)(i)
	Objecting Party	  	6.1(b)
	Other Commercialization Costs	  	Exhibit E


  
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	 DEFINITION
	  	 SECTION

		
	Out-of-Pocket Costs	  	Exhibit E
	Patent and Trademark Prosecution and Enforcement Costs	  	Exhibit E
	Patent Prosecution Expenses	  	10.2(e)
	Payments	  	9.9(a)
	Pharmacovigilance Agreement	  	5.3
	Phase IV Trial Expenses	  	Exhibit E
	PPACA	  	Exhibit E
	Product Liabilities	  	Exhibit E
	Product Trademarks	  	6.4(a)
	Proposing Party	  	6.1(b)
	Prosecuting Party	  	10.2(f)(i)
	Recall Expenses	  	Exhibit E
	Receiving Party	  	11.1
	Reconciliation Procedures	  	2.9(b)
	Redacted Version	  	11.3(b)(i)
	Regulatory Interactions	  	5.1(b)
	Regulatory Expenses	  	Exhibit E
	Regulatory Maintenance Costs	  	Exhibit E
	Requesting Party	  	11.3(b)(iii)
	Royalty Term	  	9.5(b)
	Selling Expenses	  	Exhibit E
	Step-In Enforcement Party	  	10.3(d)
	Term	  	14.1
	Third Party Activity	  	15.4(b)
	Third Party Contractors	  	8.2(a)(ii)
	Third Party Infringement	  	10.3(a)
	Third Party Infringement Action	  	10.4(a)
	Third Party Patent Costs	  	Exhibit E
	Third Party Products Liability Action	  	13.4(a)
	US Territory Loss	  	Exhibit E
	US Territory Profit	  	Exhibit E
	US Territory Profit or Loss	  	Exhibit E

 Article II 

Governance; Collaboration 

Section 2.1 General. 

(a) Governance Committees. The Parties hereby establish (i) a Joint Steering Committee (“JSC”) to oversee and
coordinate the overall conduct of all further activities concerning the Collaboration after the Effective Date; (ii) a Joint Development Committee (“JDC”) to oversee and coordinate Development (including Manufacturing of
clinical supply) of the Licensed Product(s); (iii) a Joint Commercialization Committee (“JCC”) to oversee the Commercialization (including Manufacturing of commercial supply) of the


  
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Licensed Products; (iv) the Joint Patent Committee (“JPC”) to coordinate the Prosecution of Agios Patent Rights, Agios Collaboration Patent Rights, Celgene Patent Rights and
Celgene Collaboration Patent Rights (the JSC, the JDC, the JCC and JPC shall each be referred to as a “Committee”); and (v) a joint Finance Working Group (“Finance Working Group”) to coordinate financial
aspects of the Collaboration and to act as a resource for all financial matters for each Committee as needed. Each Committee may from time to time establish subcommittees or project teams to handle matters within the scope of its authority. From and
after the Effective Date, no “Committee” or other working group established under the 2010 Agreement shall have the authority to address any matters involving this Collaboration. 

(b) Certain Interactions with and Effects on the 2010 Agreement. Upon and after the Effective Date, notwithstanding anything to the
contrary in the 2010 Agreement (with each quoted term below having the meaning given in the 2010 Agreement): 
 (i) All activities
regarding Development, Manufacturing and Commercialization of a Compound or Licensed Product containing AGI-23088 shall cease under the 2010 Agreement and all future such activities shall be conducted solely under this Agreement and the AGI-23088
ROW Agreement. 
 (ii) None of the Parties’ activities performed in accordance with this Agreement (including those activities
specifically permitted upon and after termination) shall be deemed a violation of Section 8.8 of the 2010 Agreement. 
 (iii) Neither
AGI-23088 nor any other Compound or Licensed Product is or can be (A) included as an “Agreement Compound” or in any of the classes of compounds comprising “Agreement Compounds”, (B) part of the “Compound
List,” (C) included in any of the “Picks”, or (D) part of an “Agios Reverted Program,” or “Celgene Reverted Program”. 

(iv) No payments, including any “IND Amount” or “Phase I Amount”, any milestones or any royalties, will be due under the
2010 Agreement with respect to the Licensed Products. 
 (v) No decision of any “Committee” or working group under the 2010
Agreement shall have any binding effect on any Committee or working group under this Agreement, and no decision of any Committee or working group under this Agreement shall have any binding effect on any “Committee” or working group under
the 2010 Agreement notwithstanding that the members of any such committees may contain some or all of the same individual representatives for each Party. Each meeting of a Committee or working group under this Agreement shall be conducted separately
from any meeting of a “Committee” or working group under the 2010 Agreement. 
 (vi) All “Confidential Information”
disclosed under the 2010 Agreement that solely relates to AGI-23088, Compound or any Licensed Product shall be deemed to be Confidential Information disclosed under this Agreement and not the 2010 Agreement. All “Confidential Information”
disclosed under the 2010 Agreement that relates to, but does not solely relate to, AGI-23088, Compound or any Licensed Product shall be deemed “Confidential Information” disclosed under the 2010
Agreement and also Confidential 

  
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Information disclosed under this Agreement; provided, however, that any disclosure of such information that is permitted under the 2010 Agreement shall not be deemed a breach
of this Agreement and any disclosure of such information that is permitted under this Agreement shall not be deemed a breach of the 2010 Agreement. 

Section 2.2 Joint Steering Committee. 

(a) Establishment. The initial members of the JSC for each Party will be determined by each Party, respectively, within [**] days after
the Effective Date, and the Parties will complete Exhibit H to reflect such appointments. The Parties intend that the JSC shall have the responsibility for general oversight over the Collaboration for the US Territory and for coordinating
with the JSC from the AGI-23088 ROW Territory Agreement on such matters. 
 (b) Duties. The JSC shall: 

(i) oversee and coordinate the conduct of the Collaboration and related matters within the responsibilities of the Committees hereunder; 

(ii) by Mutual Consent provide strategic guidance, and coordinate efforts between the Parties, with respect to any Publications and by Mutual
Consent approve requests for Publication, from either Party, according to Section 11.4 hereof; 
 (iii) serve as a forum for dispute
resolution in accordance with Section 2.8 with respect to matters that are not resolved at the JDC or JCC; 
 (iv) approve the initial
Development Plan (as provided in Section 1.30) and any changes thereto proposed by the JDC, in all cases by Mutual Consent; and 
 (v)
perform such other duties as are specifically assigned to the JSC under this Agreement. 
 Section 2.3 Joint Development
Committee. 
 (a) Establishment. The initial members of the JDC for each Party will be determined by each Party, respectively,
within [**] days after the Effective Date, and the Parties will complete Exhibit H to reflect such appointments. The Parties intend that the JDC shall have the responsibility for overseeing the Development of Licensed Products under the
Collaboration for the US Territory and for coordinating with the JDC from the AGI-23088 ROW Territory Agreement on such matters. 
 (b)
Duties. The JDC shall: 
 (i) review and recommend to the JSC approval of the initial Development Plan (as provided in
Section 1.30) and any proposed updates or amendments to the Development Plan (and applicable Development Budget) as needed; 

  
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 (ii) oversee, review, coordinate and provide strategic guidance to the Parties on the
Development of the Licensed Products in the US Territory, including assigning activities to be performed by each Party, subject to the provisions of Section 3.1; 

(iii) in conjunction with any committees under the AGI-23088 ROW Agreement responsible for Development of the Licensed Products, review and
coordinate such committees’ activities with respect to the Development of the Licensed Products with the Parties activities under this Agreement; 

(iv) subject to and within the parameters of each Development Plan (A) oversee the implementation of the Development Plan (including
evaluation of Clinical Trial protocols and review of the conduct of Clinical Trials conducted pursuant to the Development Plan); and (B) oversee and approve the overall strategy and positioning of all material submissions and filings with the
applicable Regulatory Authorities; 
 (v) manage the Development of any Companion Diagnostics, including the Development of any biomarkers;

 (vi) oversee, review and coordinate the studies required for the preparation of the CMC section of an IND for filing with Regulatory
Authorities for the Licensed Products, including studies relating to analytical methods and purity analysis, and (in conjunction with the JCC) formulation and Manufacturing development studies, together with associated regulatory activities; 

(vii) oversee, review and coordinate Manufacturing of Licensed Product for Development purposes; 

(viii) review and approve the content of any IND for a Licensed Product; 

(ix) develop and approve a publication plan for any Publications made prior to the First Commercial Sale of a Licensed Product in the US
Territory; 
 (x) in conjunction with the JCC, oversee and coordinate the Parties’ activities with respect to the Manufacture of
pre-clinical and clinical supply of the Licensed Products; and 
 (xi) perform such other duties as are specifically assigned to the JDC
under this Agreement. 
 Section 2.4 Joint Commercialization Committee. Upon initiation of the [**] Study with respect to a
Licensed Product or within [**] days after request by either Party if requested by either Party earlier, the Parties shall establish the JCC. The Parties intend that the JCC shall have the responsibility for overseeing the Commercialization of
Licensed Products under the Collaboration for the US Territory and for coordinating with the JCC from the AGI-23088 ROW Territory Agreement on such matters. 

  
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 (a) Duties. The JCC shall: 

(i) oversee, review and coordinate the Commercialization of the Licensed Products by the Parties in the US Territory; 

(ii) in conjunction with any committees under the AGI-23088 ROW Agreement responsible for Commercialization of the Licensed Products, review
and coordinate such committees’ activities with respect to the Commercialization of the Licensed Products with the Parties activities under this Agreement; 

(iii) develop and oversee a pricing and branding strategy for the Licensed Products; 

(iv) set overall strategic objectives and plans related to Commercialization of the Licensed Products in the US Territory; 

(v) review and approve the annual Commercialization Plan for the Licensed Products, and any updates or amendments thereto, and propose
revisions to the Commercialization Plan as needed; 
 (vi) review and approve all sales, promotional and communication materials for the
Licensed Products; 
 (vii) develop and approve a publication plan for any Publications made after the First Commercial Sale of a Licensed
Product in the US Territory; 
 (viii) provide a forum for the Parties to share information with respect to the Commercialization of the
Licensed Products; 
 (ix) review and provide strategic guidance on all Marketing Activities with respect to the Licensed Products
worldwide; 
 (x) subject to and within the parameters of the Commercialization Plan, oversee the implementation of such plan; 

(xi) confirm that both Parties’ have approved all promotional materials in accordance with the Parties’ internal copy review
procedures; 
 (xii) oversee, review and coordinate Manufacturing of commercial supply of the Licensed Products; and 

(xiii) perform such other duties as are specifically assigned to the JCC under this Agreement. 

Section 2.5 Joint Patent Committee. 

(a) Establishment. The initial members of the JPC for each Party will be determined by each Party, respectively, within [**] days after
the Effective Date, and the Parties 

  
 - 17 - 








 
will complete Exhibit H to reflect such appointments. The Parties intend that the JPC shall have the responsibility for sharing information and coordinating Patent Prosecution matters
involving Agios Patent Rights, Celgene Patent Rights, and Collaboration Patent Rights for the US Territory and for coordinating with the JPC from the AGI-23088 ROW Territory Agreement on such matters. 

(b) Duties. The JPC shall: 

(i) discuss the current status of all Agios Patent Rights, Celgene Patent Rights and Collaboration Patent Rights in the US Territory; 

(ii) discuss filing and claiming strategies involving Agios Patent Rights, Celgene Patent Rights and Collaboration Patent Rights in the US
Territory for all those existing as of the Effective Date as well as any new applications for the foregoing to be filed after the Effective Date; 

(iii) in conjunction with the JPC from the AGI-23088 ROW Territory Agreement, coordinate the timing and conduct of the Parties’
respective activities assigned to each of them under this Agreement with respect to Prosecution; 
 (iv) in conjunction with the JPC from
the AGI-23088 ROW Territory Agreement, coordinate the Parties’ respective activities in preparation for potential litigation involving the assertion of the Agios Patent Rights, Agios Collaboration Patent Rights, Celgene Patent Rights and
Celgene Collaboration Patent Rights in the US Territory under Section 10.3(c); and 
 (v) perform such other duties as are
specifically assigned to the JPC under this Agreement. 
 Section 2.6 Alliance Managers. Each Party shall appoint one designated
representative to serve as an alliance manager (“Alliance Manager”) with responsibility for being the primary point of contact between the Parties with respect to the Collaboration. The Alliance Managers shall attend JSC, JDC and
JCC meetings, as necessary, as non-voting observers. Nothing herein shall prohibit a Party from appointing its Alliance Manager as a member of one or more Committees. 

Section 2.7 General Committee Membership and Procedures. 

(a) Committee Membership. Each Committee shall each be composed of three (3) representatives from Celgene, on the one hand, and
(3) representatives from Agios, on the other hand, each of which representatives shall be of the seniority and experience appropriate for service on the applicable Committee in light of the functions, responsibilities and authority of such
Committee and the status of Development and Commercialization of the Licensed Products being pursued hereunder from time to time. Each Party may replace any of its representatives on any Committee at any time with prior written notice to the other
Party; provided that such replacement meets this standard. [**] shall appoint an initial chairperson from among its members for the JDC, and [**] shall appoint an initial chairperson from its members for the JSC and JPC and, upon its
formation, the JCC. The chairperson for each 

  
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Committee shall alternate each Calendar Year between a representative of Agios and a representative of Celgene. The initial chairperson for each Committee is indicated on Exhibit H. Within
fifteen (15) Business Days following each Committee meeting, the chairperson of each Committee shall circulate to all Committee members a draft of the minutes of such meeting. The Committee shall then approve, by Mutual Consent, such minutes
within fifteen (15) Business Days following circulation. 
 (b) Committee Meetings. 

(i) The JSC, JPC and JDC shall hold an initial meeting within [**] days of the Effective Date or as otherwise agreed by the Parties.
Thereafter, each Committee shall meet at least once every Calendar Quarter, unless the respective Committee members otherwise agree. All Committee meetings shall be conducted in person, unless otherwise determined by the applicable Committee by
Mutual Consent. 
 (ii) Unless otherwise agreed by the Parties, all in-person meetings for each Committee shall be held on an alternating
basis between Agios’ facilities in Cambridge, Massachusetts (or such future location as Agios’ facilities may move to) and Celgene’s facilities in Summit, New Jersey or San Diego, California, as determined by Celgene (or such future
location as Celgene’s facilities may move to). A reasonable number of other representatives of a Party may attend any Committee meeting as non-voting observers; provided that such additional representatives are under obligations
of confidentiality and non-use applicable to the Confidential Information of the other Party that are at least as stringent as those set forth in Article XI; and provided further that the Parties, reasonably in advance of the
applicable Committee meeting approve the list of non-voting observers to attend such meeting. Each Party shall be responsible for all of its own personnel and travel costs and expenses relating to participation in Committee meetings. 

Section 2.8 Decision Making. 

(a) Committee Voting. All decisions of a Committee shall be attempted to be made by unanimous vote, with each Party’s
representatives collectively having one (1) vote, and each such decision (if made) shall be set forth in minutes approved by both Parties’ representatives on the Committee. Upon [**] Business Days prior written notice, either Party may
convene a special meeting of a Committee for the purpose of resolving any failure to reach agreement on a matter within the scope of the authority and responsibility of such Committee. No Committee shall have the authority to resolve any dispute
involving the breach or alleged breach of this Agreement or to amend or modify this Agreement or the Parties’ respective rights and obligations hereunder. 

(b) Referrals from JDC or JCC to JSC. If the JDC or JCC is unable to decide, by unanimous vote, on any matter so referred to it for
resolution by one or both Parties within [**] Business Days after the matter is so referred to it, the Chairperson of the JDC or JCC, as applicable, shall refer such matter to the JSC for attempted resolution by unanimous vote. 

(c) Referrals from the JSC to Executive Officers. If the JSC is unable to decide, by unanimous vote, on any such matter referred to it
by the JDC or the JCC or on any 

  
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other matter specified in this Agreement to be decided by the JSC, within [**] Business Days after the matter is referred to it or first considered by it, the Chairperson of the JSC shall submit
such matter for attempted resolution by agreement of the Executive Officers. 
 (d) Decision-Making Authority. If the Executive
Officers are unable to resolve any matter referred to them by the Chairperson of the JSC within [**] Business Days after the matter is referred to them, then, subject to Section 2.8(c): 

(i) if the unresolved matter relates to the Development of the Licensed Products, including Agios Clinical-Scale Manufacturing
Responsibilities and Celgene Manufacturing Responsibilities during Development and Regulatory Interactions in a geography until Regulatory Approval for such geography, neither Party shall have final decision-making rights with respect to such matter
and neither Party may take action with respect to the unresolved matter unless and until resolved by Mutual Consent; 
 (ii) if the
unresolved matter relates to Manufacturing of the Licensed Products for Commercialization, (A) if the unresolved matter relates to Agios Commercial-Scale Manufacturing Responsibilities, then Agios shall have final decision-making rights with
respect to such matter, and (B) if the unresolved matter relates to Celgene Manufacturing Responsibilities, then Celgene shall have final decision-making rights with respect to such matter, provided that such resolving Party shall
give due consideration to any comments or preferences expressed by the other Party with respect to such matter; and 
 (iii) if the
unresolved matter relates to Commercialization of the Licensed Products: (A) subject to Section 6.3(f), Agios shall have the right to decide the unresolved matter for the US Territory except for the matters specified in subsection (ii)(B)
above, provided that Agios shall give due consideration to any comments or preferences expressed by Celgene with respect to such matter and (B) Celgene, if applicable pursuant to Section 6.3(f), shall have the right to decide
the unresolved matter for the US Territory. 
 (e) JPC. If the JPC is unable to decide, by unanimous vote, on any matter within [**]
Business Days after the matter is first raised with the JPC, then the matter will be referred to the Vice President of Intellectual Property, Chief Patent Counsel of Celgene and the Vice President of Legal of Agios (each, a “JPC
Designee”) for resolution. If such matter is not resolved by such JPC Designees of the Parties within [**] Business Days after the matter was referred to them, then the JPC Designees shall submit such matter for attempted resolution by
agreement of the Executive Officers. If the Executive Officers are unable to resolve any matter referred to them by the JPC Designees within [**] Business Days after the matter is referred to them, then, subject to Section 2.8(f), a Party may
exercise its rights to decide the matter as provided in Article X. Notwithstanding the foregoing, if at any time the Party who has decision making rights for such matter under Article X reasonably believes that the delay in decision resulting from
such procedure will create a risk that any rights to Know-How or Patent Rights will be lost or otherwise diminished, then such Party may exercise such decision making rights immediately, provided that such resolving Party shall give
due consideration to any comments or preferences expressed by the other Party with respect to such matter. 

  
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 (f) Exceptions. Notwithstanding the foregoing, neither Party shall have the right to
finally resolve a dispute pursuant to Section 2.8(d)(ii) or (iii) or 2.8(e): 
 (i) in a manner that excuses such Party from any
of its obligations specifically enumerated under this Agreement; 
 (ii) in a manner that negates any consent rights or other rights
specifically allocated to the other Party under this Agreement; 
 (iii) to resolve any dispute involving the breach or alleged breach of
this Agreement; 
 (iv) to resolve any dispute regarding whether a milestone event set forth in Section 9.3 has been achieved; 

(v) to resolve a matter if the provisions of this Agreement specify that mutual agreement of the Parties or a Mutual Consent is required for
such matter; or 
 (vi) in a manner that would require the other Party to perform any act that is inconsistent with any Law. 

Section 2.9 Finance Working Group. 

(a) Establishment. Within [**] days after the Effective Date, the Parties shall establish the Finance Working Group. The Finance
Working Group shall include individuals from each Party with reasonable expertise in the areas of accounting, cost allocation, budgeting financial reporting and tax. Membership and governance of the Finance Working Group shall be as set forth in
Section 2.7 as if the Finance Working Group were a Committee for the limited purpose of such Section. The Parties intend that the Finance Working Group shall have the responsibility for the matters set forth in subsection (b) of this
Section 2.9 with respect to the US Territory and for coordinating with the Finance Working Group from the AGI-23088 ROW Territory Agreement on such matters. 

(b) Duties. The purpose of the Finance Working Group is to provide financial information as requested to the JDC and JSC with respect
to the Development of the Licensed Products, to the JCC and JSC with respect to the Commercialization of the Licensed Products, and to the JSC with respect to the preparation and approval of US Territory Profit or Loss statements in accordance with
the provisions of Section 9.4 and Exhibit E to this Agreement (the “Financial Exhibit”). The Finance Working Group will also develop procedures for quarterly reporting of actual results and review and discussion of
potential discrepancies, quarterly reconciliation, reasonable forecasting and for each Party’s review of the applicable books and records of the other Party, as well as other finance, tax and accounting matters, to the extent not set forth in
the provisions below or in the Financial Exhibit (the “Reconciliation Procedures”). Such procedures must be established in a manner that provides the ability to comply with financial reporting requirements of each Party. The Finance
Working Group shall be responsible for: 
 (i) coordinating and conducting the accounting, reporting, reconciliation and other related
activities set forth in this Agreement and the Financial Exhibit; 

  
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 (ii) advising and providing support to the JSC and the other Committees with respect to
financial, accounting, tax, budgeting, reporting and other issues that may arise in connection with the various plans and corresponding budgets for activities thereunder; 

(iii) reviewing relevant FTE Costs and Out-of-Pocket Costs incurred by the Parties and their Affiliates hereunder; 

(iv) recommending for approval by the JSC any changes to reporting procedures; 

(v) coordinating or performing the budgeting, consolidation, completion and review of Development Cost and US Territory Profit or Loss
statements in accordance with the Reconciliation Procedures and the Financial Exhibit, including budgeting and calculation of expenses not covered in the Development Budget or the Commercialization Budget; 

(vi) establishing the overall FTE Rate to be applied to each FTE devoted to Commercialization on a country-by-country basis at least [**]
months prior to commencement of Commercialization activities (including pre-launch activities) and annually thereafter in connection with updates to the Commercialization Plan; such overall FTE Rate for a country to be set in consideration of the
wages and salaries, employee benefits, bonus, automobile allowance, meal expenses, travel/housing for meetings, dues, subscriptions, meetings and purchased services (including training, recruitment, communications, repairs and maintenance, and
contractors), and other incidental expenses incurred by each such FTE in the ordinary course of employment and other things as may be determined by the JCC; 

(vii) performing and reviewing calculations for the reconciliation of payments, and controlling and performing such other accounting
functions as provided in the Financial Exhibit; 
 (viii) coordinating audits pursuant to Section 9.8 by Audit Teams, and discussing
and attempting to resolve discrepancies or issues arising from such audits; 
 (ix) performing such other functions as are specifically
designated to the Finance Working Group in this Agreement or the Financial Exhibit, or as the Parties otherwise agree are appropriate to further the purposes of this Agreement; 

(x) working with the JSC, JDC and JCC to assist in financial, accounting, tax, budgeting and planning matters if and as requested by the
respective Committee, and providing periodic updates to the JSC, JDC (if requested) and JCC on financial matters relating to this Agreement, and performing such other financial matters as are delegated to it under this Agreement or by the JSC, JDC
and JCC; and 
 (xi) making such decisions and determinations as are assigned to it under this Agreement. 

  
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 Section 2.10 Scope of Governance. Notwithstanding the creation of each of the
Committees and the Finance Working Group, each Party shall retain the rights, powers and discretion granted to it under this Agreement, and neither any Committee nor the Finance Working Group shall be delegated or vested with rights, powers or
discretion unless such delegation or vesting is expressly provided herein, or the Parties expressly so agree in writing. It is understood and agreed that issues to be formally decided by a particular Committee are only those specific issues that are
expressly provided in this Agreement to be decided by such Committee, as applicable, and (except with respect to Section 2.9(b)(vi)) that the Finance Working Group has no decision making authority whatsoever. 

Section 2.11 Agios Participation. Notwithstanding anything in this Article II to the contrary, at any time, Agios shall have the
right, but not the obligation, to participate in, and may elect not to appoint members to, any given Committee, the Finance Working Group, subcommittee or project team. If Agios elects not to participate in, or does not appoint members to, any
Committee, subcommittee or project team, (a) it shall not be a breach of this Agreement; (b) no consideration shall be required to be returned; (c) unless and until such members are appointed, Celgene may unilaterally discharge the
roles of such Committee, subcommittee or project team, as applicable, for which members were not appointed by Agios, including making in Celgene’s sole discretion all decisions of such Committee, subcommittee, or project team, including
decisions requiring Mutual Consent; provided that Celgene shall not unilaterally discharge the roles of such Committee, subcommittee or project team, as applicable, as permitted under this Article II unless Agios has not appointed any
members within [**] days after Celgene has completed its appointment of its members; and (d) Agios shall abide by all decisions made by Celgene on behalf of the applicable Committee, subcommittee, or project team and shall continue to perform
its obligations hereunder. If Agios thereafter appoints members to a Committee, subcommittee or project team, Celgene shall no longer have the unilateral right to discharge the role of such Committee, subcommittee or project team, as applicable;
provided that such Committee, subcommittee or project team shall not thereafter repeal prior decisions made by Celgene when Celgene was unilaterally discharging such role. 

Section 2.12 Agios Opt-Out. 

(a) Opt-Out Notice and Date. Without it being a breach of Article VII, following the first anniversary of the Effective Date, Agios
shall have the right, effective upon twelve (12) months’ prior written notice (which notice shall may not be given prior to the first anniversary of the Effective Date), to elect to opt-out of its Development, Manufacturing and
Commercialization rights and the sharing of Development Costs and US Territory Profit or Loss under both this Agreement and the AGI-23088 ROW Agreement (such notice, the “Agios Opt-Out Notice”, the effective date of such Agios
Opt-Out Notice, subject to Section 2.12(b), being the expiration of such 12-month period, the “Agios Opt-Out Date”; provided, however, that Agios may not, without consent of Celgene, provide any such notice
(x) within [**] months after any Regulatory Authority or the other Party has provided to any Committee or Agios any notification under Section 5.4 that a recall, market withdrawal or similar action may be required with respect to any
Licensed Product or (y) within [**] months after any Committee or Agios receives knowledge of any Third Party Products Liability Action. 

  
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 (b) Effects of Agios Opt-Out Notice or Date. Following the Agios Opt-Out Notice: 

(i) the license and sublicense granted to Agios under Section 8.1(b) shall terminate effective as of the Agios Opt-Out Date; 

(ii) effective as of the Agios Opt-Out Date, all decisions relating to Development, Manufacturing or Commercialization that require decision
by a Committee or that are subject to Mutual Consent shall be made solely by Celgene and all decisions for which Agios was provided with final decision-making authority under Section 2.8 or Article 10 shall be made solely by Celgene;
provided that Celgene shall exercise any such decision-making authority in a manner consistent with a commitment of Commercially Reasonable Efforts to the Development and Commercialization of the Licensed Products in the US Territory;
provided, further, that if Celgene or its Affiliate propose(s) to take or take(s) any action not contemplated by the Development Plan in effect on the Agios Opt-Out Date, and that Agios reasonably determines is reasonably likely
to have a material adverse impact on the Commercialization of any of the “Licensed Products,” as such term is defined in the 2010 Agreement, then Agios shall provide written notice to such effect to Celgene specifying in reasonable detail
which actions by Celgene or its Affiliates would have such an effect, and what such effect would be. The Parties shall use good faith efforts to discuss the pertinent actions and resolve the matter. If Celgene concurs with Agios’ determination,
Celgene and its Affiliates shall not proceed with, or shall cease as quickly as reasonably possible, as applicable, such action without the written consent of Agios. If Celgene does not concur with Agios’ determination, Celgene may present the
issue to the Executive Officers for resolution pursuant to Section 15.1(a) and, if agreement is not reached, may seek resolution of such matter in accordance with Section 15.1(b); 

(iii) neither Party shall have any further obligations under the Development Plan or Commercialization Plan effective as of the Agios Opt-Out
Date; 
 (iv) effective as of the Agios Opt-Out Date, Celgene (but not Agios) shall continue to have obligations under Section 7.1(b)
and 7.2, but neither Party shall have any obligations under Section 7.1(a); 
 (v) Celgene shall be solely responsible for all
Development Costs and Commercialization Expenses for the Licensed Products incurred after the Agios Opt-Out Date, except as provided in clause (vi) immediately below and as provided in Sections 5.4, 13.3 and 13.4; 

(vi) effective as of the Agios Opt-Out Date, Agios shall cease to conduct any further Development or Commercialization activities (including
Marketing Activities) with respect to any Licensed Products and cease to incur any further Development Costs or Commercialization Expenses except as approved by Celgene or as provided in Sections 5.4, 13.3 and 13.4; 

  
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 (vii) within [**] days after the Agios Opt-Out Date, Agios shall provide to Celgene a reasonably
detailed accounting of all Development Costs and Commercialization Expenses incurred by Agios under the Collaboration prior to the Agios Opt-Out Date for the purpose of calculating a final reconciliation of shared costs through the Agios Opt-Out
Date in accordance with Sections 9.2 and 9.4; 
 (viii) within [**] days after the Agios Opt-Out Notice, Agios shall provide to Celgene a
reasonably detailed summary of Development and Commercialization activities undertaken by Agios under the Collaboration, including any Clinical Trials committed but not yet completed as of such date, and Agios shall provide to Celgene an update to
such summary within [**] days after the Agios Opt-Out Date; 
 (ix) Agios shall undertake, and coordinate with Celgene with respect to, any
wind-down or transitional activities reasonably necessary to transfer to Celgene all Development, Manufacturing (including all Agios Clinical-Scale Manufacturing Responsibilities and Agios Commercial-Scale Manufacturing Responsibilities) and
Commercialization responsibility for the Licensed Products throughout the Territory, at Agios’ sole expense, including those activities referenced in Section 14.3(b)(viii), all of which must be completed before the Agios Opt-Out Date;
provided that the Parties shall reasonably cooperate in seeking to minimize the costs of such wind-down or transitional activities; provided further that, (A) if Celgene requests that any contracts or
agreements that extend beyond the Agios Opt-Out Date be terminated, Agios and Celgene shall share all costs associated with such termination, and, (B) if Celgene requests that any such contract or agreement remain in effect, Celgene shall be
responsible for all Development Costs and Commercialization Expenses under such contract or agreement following the Agios Opt-Out Date or, if Celgene requests assignment of such contract or agreement prior to the Agios Opt-Out Date, following such
assignment (whichever is earlier); 
 (x) Celgene shall have the option to obtain Agios’ inventory of the Licensed Products and their
active pharmaceutical ingredients at a price equal to [**] of Agios’ Manufacturing Costs; 
 (xi) in the event Agios is utilizing a
Third Party manufacturer to Manufacture the Licensed Products or their active pharmaceutical ingredients, to the extent permitted by the terms of such contract, Agios shall, if requested by Celgene, promptly assign to Celgene the manufacturing
agreements with such Third Party with respect to such products and ingredients; 
 (xii) Agios shall transfer, or have transferred, to
Celgene or its designee, pursuant to a technology transfer plan to be mutually agreed by the Parties promptly after the Agios Opt-Out Notice, all Manufacturing Technology Controlled by Agios or AIS within Agios Intellectual Property that is both
necessary to Manufacture the Licensed Products or their active pharmaceutical ingredients as Manufactured by or on behalf of Agios and its Affiliates, and Agios shall provide reasonable assistance in connection with the transfer of such
Manufacturing Technology to Celgene or its designee, all of which shall be deemed Development Costs and shall be completed before the Agios Opt-Out Date; 

  
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 (xiii) effective as of the Agios Opt Out Date, each Licensed Product shall be subject to the
royalty provisions of Section 9.5 from and after the Agios Opt-Out Date, in lieu of the sharing of Development Costs under Section 9.2 and US Territory Profit or Loss under Section 9.4; 

(xiv) as quickly as reasonably possible but in no event later than the Agios Opt-Out Date, Agios shall transition to Celgene Agios’
initial Prosecution and enforcement responsibilities with respect to Agios Patent Rights, Agios Collaboration Patent Rights, Joint Inventions and Joint Patents, and provide reasonable assistance to Celgene and cooperation in connection therewith,
including execution of such documents as may be necessary to effect such transition, provided that Agios shall retain step-in rights under Section 10.2(b) as well as comparable step-in rights on Prosecution matters relating to
Agios Patent Rights and Agios Collaboration Patent Rights that are not Joint Patents but not under Section 10.3; and 
 (xv) The
AGI-23088 ROW Agreement will be affected in a corresponding manner as provided therein. 
 Article III 

Development 

Section 3.1 Development of Licensed Products. 

(a) Development Plan and Changes. Once the Development Plan has been mutually agreed, the Parties shall undertake the Development of
Licensed Products on a worldwide basis in accordance with the Development Plan, including the [**] budget of Development Costs (“Development Budget”). The JDC may propose changes to the Development Plan to the JSC. The Development
Plan may be amended from time to time only by Mutual Consent of the JSC. 
 (b) Development Responsibilities. Each Party shall use
Commercially Reasonable Efforts to perform the activities assigned to it in accordance with the specifications, timelines and budgets indicated in the Development Plan, provided that if Agios so desires, the Development Plan shall
specify that Agios shall be responsible for conducting all Phase I Studies of the Licensed Product in the Territory. For purposes of clarity, except as provided in Section 3.3, neither Party shall undertake any Development activities relating
to the Licensed Products that are not specifically allocated to such Party in the Development Plan. 
 (c) General Development
Principles. It is the intent of the Parties that Development of the Licensed Products will be conducted in accordance with the following principles, except to the extent (if any) otherwise expressly provided in the then-current Development Plan.
The JDC (or the JSC or the Executive Officers as applicable) shall take into account and attempt to implement the following principles in its decision-making, including preparation, review and approval of any updates to and amendments of the
Development Plan. 
 (i) Regardless of the specific division of responsibility between the Parties for particular activities at any
particular time, the JDC (and JSC) shall serve as a conduit for sharing information, knowledge and expertise relating to the Development of the Licensed Products. 

  
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 (ii) Clinical Development of the Licensed Products should be performed according to a single,
integrated global program (with, for the avoidance of doubt, allowance of Additional Development Activities as provided in Section 3.3). 

(iii) The Development Plan should include an allocation of responsibilities between the Parties reasonably determined after taking into
consideration each Party’s expertise, capabilities, staffing and available resources to take on such activities. 
 (iv) After receipt
of Regulatory Approval of a Licensed Product in any Major Market, the Development Plan should (absent special circumstances or significant changes in circumstances) include pursuit of Regulatory Approval for such Licensed Product in all other Major
Markets and such other countries as the JSC deems appropriate. 
 (d) Coordination and Reports. Each Party shall coordinate with, and
keep the JDC informed with respect to, activities assigned to such Party under the Development Plan, including the conduct of any applicable Clinical Trials. Each Party shall provide the JDC with regular [**] written reports on such Party’s
Development activities relating to the Collaboration, including a summary of results, information, and data generated, any activities planned with respect to Development going forward (including, for example, updates regarding regulatory matters and
Development activities for the next [**]), challenges anticipated and updates regarding intellectual property issues (including a disclosure of Collaboration Intellectual Property developed or generated since the last written report) relating to the
Collaboration. Such written reports may be discussed by telephone or video-conference, or may be provided at each JDC meeting; provided that, reasonably in advance of the meeting of the JDC, the Party providing the written report will
deliver to the JDC an agenda setting forth what will be discussed during the meeting. The Party receiving such written report shall have the right to reasonably request, and to receive in a timely manner at or after the JDC meeting, clarifications
and answers to questions with respect to such reports. 
 Section 3.2 Development Costs. The Parties will share all Development
Costs in accordance with Section 9.2. 
 Section 3.3 Additional Development Activities. Subject to Section 2.12, each
Party shall be permitted (i) to undertake Development activities (including Clinical Trials) not contemplated by the Development Plan (for example, a Clinical Trial for an Indication not included in such plans) or (ii) to repeat any
Clinical Trial previously conducted under the Development Plan that failed to meet its primary endpoints (collectively, “Additional Development Activities”); provided that such Party complies with the provisions of
this Section 3.3. 
 (a) Additional Development Proposals. If a Party desires to undertake Additional Development Activities,
such Party shall submit to the JDC a proposal for the addition of such Additional Development Activities to the Development Plan (an “Additional Development Proposal”). Each Additional Development Proposal for Additional Development
Activities shall include a general description of the Development activities including, as applicable, study design, clinical study endpoints, clinical methodology and monitoring requirements, and the funding budget. If the JDC approves an
Additional Development Proposal, such Additional Development Proposal shall, within [**] days, be submitted to the JSC for review and approval. 

  
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 (b) Inclusion of Additional Development Activities in the GDP. If the JSC approves an
Additional Development Proposal, the Development Plan shall be deemed to be amended to include the Additional Development Activities and associated budget upon approval of such Additional Development Proposal by the JSC. For the sake of clarity, all
Development Costs incurred by the Parties and their Affiliates in performing such Additional Development Activities shall be shared by the Parties in accordance with Section 9.2. 

(c) Independent Performance of Additional Development Activities. If the JDC does not approve an Additional Development Proposal within
[**] days after its submission to the JDC, or the JSC does not approve an Additional Development Proposal within [**] days after its submission to the JSC, then the Party that submitted the Additional Development Proposal (the “Additional
Development Party”) may, upon notice to the other Party, conduct the relevant Additional Development Activities in accordance with the Additional Development Proposal at its own expense; provided, however, that, if the
other Party (the “Non-Additional Development Party”) determines reasonably and in good faith that any of the proposed Additional Development Activities is reasonably likely to adversely affect
the Development, Manufacturing or Commercialization of any of the Licensed Products or “Licensed Products” as such term is defined in the 2010 Agreement, then the Additional Development Party shall not undertake such Additional Development
Activities unless and until the JDC or JSC determines that such Additional Development Activities should be permitted. Additional Development Activities undertaken by the Additional Development Party shall be subject to the oversight of the JDC and,
except as expressly set forth in this Section 3.3(c), subject to all terms and conditions of this Agreement relating to Development of Licensed Products (including the license grants in Article VIII). For clarity, a Licensed Product that is the
subject of Additional Development Activities shall continue to be a “Licensed Product” for all purposes of this Agreement. The Additional Development Party shall provide informal reports of its progress with regard to the Additional
Development Activities at each meeting of the JDC and shall provide formal written reports of the results and budgeted costs of the Additional Development Activities to the JDC at least [**] during the first [**] months in which any Clinical Trial
within the Additional Development Activities is being performed, and otherwise in the same manner and frequency as the Parties provide reports to the JDC with respect to activities covered by the Development Plan. If, at any time after the
commencement of an Additional Development Activity, the Non-Additional Development Party determines reasonably and in good faith that any Additional Development Activity is reasonably likely to adversely affect the Development or Commercialization
of the Licensed Products or “Licensed Products” as such term is defined in the 2010 Agreement, the Non-Additional Development Party shall so notify the Additional Development Party and such Additional Development Activity shall be promptly
discontinued (subject to such ethical obligations to continue support of patients already enrolled in Clinical Trials, as the Additional Development Party may in good faith determine) unless and until the JDC or JSC determines that such Additional
Development Activities should be permitted to continue. 
 (d) Costs of Additional Development Activities. The Additional Development
Party shall bear all costs associated with the Additional Development Activities it 

  
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undertakes and such costs shall not be taken into account as Development Costs for purposes of Section 9.2. If the JSC determines, by Mutual Consent, to include Data generated from such
Additional Development Activities (excluding only safety Data) for label expansion purposes in a submission for Regulatory Approval for a Licensed Product or for other specific commercial purposes, the Non-Additional Development Party shall
reimburse the Additional Development Party an amount equal to [**] percent ([**]%) of the costs incurred by the Additional Development Party for the Additional Development Activities (to the extent not previously reimbursed pursuant to
Section 3.3(e)). Such costs will be determined using the same manner of calculating Development Costs under the Development Plan. 

(e) Opt-In for Additional Development Activities. In the event that the Non-Additional Development Party elects, in its discretion and
upon written notice to the Additional Development Party (an “Additional Development Opt-In Notice”), on a Clinical Trial-by-Clinical Trial basis, to opt in with respect to a given Clinical Trial within the Additional Development
Activities, then: 
 (i) such Clinical Trial shall be deemed to be included in the Development Plan from and after the date on which such
Additional Development Opt-In Notice is received by the Additional Development Party (the “Additional Development Opt-In Date”); 

(ii) the then-current plan and budget of the Additional Development Party with respect to such Clinical Trial shall be deemed to be included
within and part of the Development Plan from the Additional Development Opt-In Date, and shall control with respect to such Clinical Trial unless and until an amendment to the Development Plan providing for a different or modified plan and budget is
approved by the JSC; 
 (iii) the Out-of-Pocket Costs and FTE Costs associated with such Clinical Trial incurred after the Additional
Development Opt-In Date shall be treated as Development Costs and shared by the Parties in accordance with Section 9.2; and 
 (iv)
the Non-Additional Development Party shall reimburse the Additional Development Party an amount equal to [**] percent ([**]%) of the costs incurred prior to the Additional Development Opt-In Date by the Additional Development Party and its
Affiliates for such Clinical Trial (to the extent not previously reimbursed pursuant to Section 3.3(d)). Such costs will be determined using the same manner of calculating Development Costs under the Development Plan. 

Section 3.4 Companion Diagnostics. 

(a) Development of Companion Diagnostic. The Parties may mutually agree to Develop and/or Commercialize a Companion Diagnostic for use
with the Licensed Products; provided that, the Parties will use a Third Party Contractor reasonably acceptable to both Parties to perform all Development and Commercialization for the Companion Diagnostic. In such event, (i) the
definition of “Licensed Product” shall and hereby does include the Companion Diagnostic for purposes of defining Agios Patent Rights, Celgene Patent Rights and Collaboration Patent Rights, and each of the licenses granted to a Party under
Section 8.1 or 8.2; and (ii) all costs and profits with respect to such Development or Commercialization of the Companion Diagnostic shall be shared equally by the Parties pursuant to a mechanism agreed to by the Parties at the time the
Third Party Contractor is appointed. 

  
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 (b) Separate Obligations. No payments shall be owed by Celgene to Agios pursuant to
Sections 9.3 through 9.5 with respect to a Companion Diagnostic. Upon termination of this Agreement, or reversion of rights to a Party with respect to the Licensed Products, in addition to the effects of such termination or reversion set forth in
Section 14.3, separate transitional activities shall be undertaken with respect to the Companion Diagnostic to ensure that the appropriate Regulatory Approvals, Manufacturing Technology or other Know-How or Patent Rights necessary for the
Development, Manufacture and/or Commercialization of such Companion Diagnostic shall be transferred to the Party to whom the rights to the Licensed Products are transferred to the same extent as Regulatory Approvals, Manufacturing Technology or
other Know-How or Patent Rights otherwise associated with such Licensed Products are transferred. 
 (c) No Other Diagnostics. For
purposes of clarity, unless otherwise mutually agreed by the Parties, neither Party shall have any right, under the licenses granted to such Party pursuant to Section 8.1 and notwithstanding the definition of “Field” hereunder, to
Develop, Manufacture and/or Commercialize any biomarker or diagnostic product for use with the Licensed Products, other than a Companion Diagnostic pursuant to this Section 3.4. 

Section 3.5 Records; Tech Transfer. 

(a) Maintenance of Records. Each Party shall maintain in all material respects, and shall require its Third Party Contractors to
maintain in all material respects, complete and accurate records in segregated books of all Development work conducted in furtherance of the Collaboration and all results, data and developments made in conducting such activities. Such records shall
be complete and accurate and shall fully and properly reflect all such work done and results achieved in sufficient detail and in good scientific manner appropriate for patent and regulatory purposes. Each Party shall require the applicable study
sites to maintain original source documents from Clinical Trials of the Licensed Products for at least [**] years (or such longer period as is commercially reasonable under the circumstances, taking into account maintenance requirements under
applicable Law) following completion of the Development activities undertaken by such Party or its Third Party Contractors; provided that Celgene or Agios shall be entitled to obtain copies of such source documents at the end of such
[**]-year period. 
 (b) Inspection. Each Party shall have the right, during normal business hours and upon reasonable notice, to
inspect and copy (or request the other Party to copy) all records of the other Party or its Third Party Contractors, as applicable, maintained in connection with the work done and results achieved in the performance of Development activities under
the Collaboration, but solely to the extent access to such records is necessary for such Party to exercise its rights under this Agreement. 

(c) Tech Transfer. As soon as reasonably practical after the Effective Date and thereafter upon Celgene’s reasonable request
during the Term, Agios shall transfer to Celgene[**] copies of all Agios Know-How and Agios Collaboration Know-How related to the 

  
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Licensed Product, to the extent not previously transferred to Celgene. Upon Agios’ reasonable request during the Term, Celgene shall transfer to Agios[**] copies of all Celgene Know-How and
Celgene Collaboration Know-How related to the Licensed Product, to the extent not previously transferred to Agios. In addition, each Party shall provide reasonable assistance, including making its personnel reasonably available for meetings or
teleconferences to answer questions and provide technical support to the other Party with respect to the use of such transferred Know-How in the Development, Manufacture and Commercialization of Licensed Products. The costs and expense incurred by
either Party in connection with such assistance shall constitute Development Costs. 
 Article IV 

Manufacture and Supply 

Section 4.1 Pre-Clinical, Clinical and Commercial Supply. 

(a) Agios Responsibilities. Agios shall be responsible for Manufacturing, or having Manufactured by its designee, (i) all
pre-clinical supply of Licensed Products, (ii) all supply of Licensed Products for Phase I Studies, (iii) all active pharmaceutical ingredients for all Phase II Studies and Phase III Studies (collectively, items (i), (ii) and (iii),
the “Agios Clinical-Scale Manufacturing Responsibilities”), and (iv) all active pharmaceutical ingredients for Commercialization of Licensed Products (the “Agios Commercial-Scale Manufacturing
Responsibilities”). Agios shall fulfill a substantial portion of the Agios Commercial-Scale Manufacturing Responsibilities from within, and ship all such Licensed Products and active pharmaceutical ingredients to Celgene from, Agios’
or its designee’s manufacturing facility located in Switzerland or another country mutually agreed in writing by the Parties such that the Licensed Products are treated as manufactured in Switzerland or such other country for purposes of
Section 954(d) of the Code and Section 1.954-3(a)(2) of the Treasury Regulations (or any other similar provision of the Code or Treasury Regulations in effect as of any time); provided that Agios may obtain raw materials from
any country as determined by Agios for use in connection with the Agios Commercial-Scale Manufacturing Responsibilities, and provided further that if Celgene disagrees that the fulfillment of the Agios Manufacturing
Responsibilities is such that the Licensed Products are so treated, Agios shall deliver to Celgene an opinion of an independent nationally recognized law or accounting firm that the Licensed Products should be so treated. 

(b) Agios Commercial-Scale Manufacturing Responsibilities. Agios or its Affiliate may have any Third Party conduct on behalf of Agios
any of the Agios Commercial-Scale Manufacturing Responsibilities, provided that, from the period commencing on the Effective Date and ending on the first to occur of (i) the first date upon which Celgene and Agios are Affiliates, and
(ii) a Change of Control of Celgene, Agios shall notify Celgene at least [**] months prior to the time at which it anticipates it will engage a Third Party to conduct such activities, and the Parties thereafter shall discuss the selection of
the Third Party, provided that Celgene may, in its discretion, indicate that it is interested in undertaking the applicable Agios Commercial-Scale Manufacturing Responsibilities, in which event the Parties shall discuss that as well.
Agios retains the right to determine whether a Third Party or Celgene shall conduct the applicable Agios Commercial-Scale Manufacturing Responsibilities, and the terms thereof, provided that such manufacturing still conforms to the requirements of
Section 4.1(a). 

  
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 (c) Celgene Responsibilities. Celgene shall be responsible for Manufacturing, or having
Manufactured by its designee, all supply of Licensed Products not included within Agios Clinical-Scale Manufacturing Responsibilities and Agios Commercial-Scale Manufacturing Responsibilities, including drug product manufacturing and processing,
filling, packaging, labeling, shipping and storage of Licensed Products for all Clinical Trials (other than Phase I Studies) and for Commercialization of Licensed Products (collectively, the “Celgene Manufacturing
Responsibilities”). Celgene shall fulfill a substantial portion of the Celgene Manufacturing Responsibilities from within Celgene’s or its designee’s manufacturing facility located in Switzerland or another country mutually agreed
in writing by the Parties such that the Licensed Products are treated as manufactured in Switzerland or such other country for purposes of Section 954(d) of the Code and Section 1.954-3(a)(2) of the Treasury Regulations (or any other
similar provision of the Code or Treasury Regulations in effect as of any time); provided that Celgene may obtain raw materials from any country as determined by Celgene for use in connection with the Celgene Manufacturing
Responsibilities, and provided further that if Agios disagrees that the fulfillment of the Celgene Manufacturing Responsibilities is such that the Licensed Products are so treated, Celgene shall deliver to Agios an opinion of an
independent nationally recognized law or accounting firm that the Licensed Products should be so treated. 
 (d) Manufacturing Costs.
Manufacturing Costs associated with clinical supply of the Licensed Products shall be shared in accordance with Section 9.2. Manufacturing Costs associated with commercial supply of the Licensed Products shall constitute Commercialization
Expenses. 
 Section 4.2 Third Party Manufacturers. If either Party uses any Third Party to fulfill its Manufacturing
obligations or rights under Section 4.1 with respect to any supply to be used in any Development or Commercialization activities under the Collaboration, the Third Party and the terms of the agreement with such Third Party must be approved by
the JDC or JCC, as applicable, in each case subject to Section 2.8. 
 Section 4.3 Transfer of Manufacturing
Responsibility. In order to assist Celgene to perform the Celgene Manufacturing Responsibilities or, if selected by Agios pursuant to Section 4.1(b), the Agios Commercial-Scale Manufacturing Responsibilities, Agios shall (a) transfer,
or have transferred, to Celgene or its designee, pursuant to a technology transfer plan to be mutually agreed by the Parties, all Manufacturing Technology Controlled by Agios or AIS and used in Manufacturing Licensed Products at the time of such
transfer to the extent relevant to the Celgene Manufacturing Responsibilities or, if selected by Agios pursuant to Section 4.1(b), the Agios Commercial-Scale Manufacturing Responsibilities, and (b) provide reasonable assistance in
connection with the transfer of such Manufacturing responsibility to Celgene or its designee. Costs incurred by either Party in such transfer shall be Development Costs. 

Section 4.4 Manufacturing Efforts. The Party that is responsible for Manufacturing hereunder shall use Commercially Reasonable
Efforts to ensure adequate manufacturing capacity to meet forecast demand for the applicable Licensed Product, including, if deemed necessary by the JDC or JCC, as applicable, the establishment of an alternative supply source. Such Party shall also
use Commercially Reasonable Efforts to ensure adequate pre-clinical, clinical and commercial supply of the applicable Licensed Product for both Parties to Develop and/or Commercialize, as applicable, such Licensed Products as contemplated under the
applicable Development Plan and/or Commercialization Plan. 

  
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 Article V 

Regulatory Matters 

Section 5.1 Lead Responsibility for Regulatory Interactions. Except as may otherwise be mutually agreed by the Parties or the JSC,
JDC or JCC, as applicable, and subject to oversight by the JSC, JDC or JCC: 
 (a) Lead Responsibility. Agios shall have the initial
lead responsibility for all Regulatory Interactions with Regulatory Authorities in the US Territory with respect to each Licensed Product unless and until there is a transfer thereof to Celgene as provided in Section 5.1(c). Celgene shall have
lead responsibility for all Regulatory Interactions with Regulatory Authorities in the US Territory for the applicable Licensed Product after any such transfer to the extent set forth in Section 5.1(c). The JDC may propose to the JSC a
different allocation for the roles of each Party for all Regulatory Interactions in the US Territory but such roles may only be changed by Mutual Consent of the JSC. 

(b) Regulatory Interactions Defined. For purposes of this Agreement, “Regulatory Interactions” means
(i) monitoring and coordinating all regulatory actions, preparing, submitting and coordinating all communications and filings with, and submissions to, all Regulatory Authorities in the US Territory with respect to the Licensed Products and
(ii) interfacing, corresponding and meeting with the Regulatory Authorities in the US Territory with respect to the Licensed Products. 

(c) Transfer of Regulatory Responsibility in US Territory. At any time after either an Agios Opt-Out Notice or the date that is [**]
days prior to the expected commencement of a Phase III Study for a Licensed Product, Celgene may notify Agios that Celgene desires to take over lead responsibility for the Regulatory Interactions in the US Territory for such Licensed Product. Upon
and after such notice from Celgene: 
 (i) Agios shall (1) at Celgene’s option, either close or inactivate Agios’ IND(s) for
such Licensed Product, or transfer such IND(s) to Celgene, and (2) with Celgene input, complete all relevant activities related to such IND as required for Celgene to assume regulatory ownership, as applicable, all within [**] days after
Celgene’s notice; 
 (ii) Celgene shall be responsible for the preparation and filing of all regulatory filings with respect to any
subsequent Development, Manufacturing or Commercialization for Licensed Products after such activities described in clause (i) above are completed; and 

(iii) Agios shall provide Celgene with all relevant clinical and non-clinical data reasonably requested by Celgene or a Regulatory Authority,
including CMC, pharmacology and toxicology generated by Agios with respect to the subject Licensed Product. 
 If Celgene does not provide notice to Agios
in accordance with this Section 5.1(c) that Celgene desires to take over lead responsibility for the Regulatory Interactions in the US Territory associated with a Licensed Product, Agios shall retain lead responsibility for all Regulatory
Interactions in the US Territory with respect to such Licensed Product. 

  
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 Section 5.2 Participation Rights. 

(a) Review of Regulatory Documentation. Each Party shall keep the JDC reasonably informed in connection with all Regulatory
Interactions, preparation of all Regulatory Documentation, Regulatory Authority review of Regulatory Documentation, Regulatory Approvals, annual reports, including annual safety reports to the respective health authorities, annual re-assessments,
and any subsequent variations and changes to labeling, in each case with respect to the Licensed Products. Each Party shall respond within a reasonable time frame to all reasonable inquiries by the other Party with respect to any information
provided pursuant to this Section 5.2(a) (and sufficiently promptly for the other Party to provide meaningful input with respect to responses to Regulatory Authorities). 

(b) Participation in Meetings. The Party not having the lead responsibility for Regulatory Interactions in a country with respect to
the Licensed Products shall have the right to have two senior, experienced employees reasonably acceptable to the responsible Party, participate as an observer in material or scheduled face-to-face meetings, video conferences and any teleconferences
with the applicable Regulatory Authority, and shall be provided with advance access to the responsible Party’s material documentation prepared for such meetings. 

(c) Review. Prior to submission of material correspondence to any Regulatory Authority with respect to the Licensed Products, the Party
having the lead responsibility for Regulatory Interactions shall, sufficiently in advance for the other Party to review and comment, provide the other Party any material correspondence with the Regulatory Authority related to such meetings. The
responsible Party shall also provide the other Party with copies of any material correspondence with Regulatory Authorities relating to Development of, or the process of obtaining Regulatory Approval for, the Licensed Products in such Party’s
territory (i.e., initially the US Territory if the responsible Party is Agios, or the ROW Territory if the responsible Party is Celgene), and respond within a reasonable time frame to all reasonable inquiries by the other Party with respect
thereto. 
 Section 5.3 Global Safety Database; Pharmacovigilance Agreement. At a time to be mutually agreed by the Parties, the
Parties shall establish, hold and maintain a single electronic system for the collection and storage of all safety information for the Licensed Products (the “Global Safety Database”). Such database shall comply in all material
respects with all Laws reasonably applicable to pharmacovigilance anywhere where the Licensed Products are being or have been Developed or Commercialized. Unless the Parties otherwise agree in the Pharmacovigilance Agreement, Agios shall initially
be responsible for the Global Safety Database for the Licensed Products, and Celgene shall assume control on a Licensed Product-by-Licensed Product basis following the transfer, if any, of lead responsibility for Regulatory Interactions in the US
Territory for such Licensed Product to Celgene pursuant to Section 5.1(c). The Party not maintaining the Global Safety Database may hold and maintain a parallel safety database for the Licensed Products as needed or required according to
applicable Laws. The Parties will use Commercially Reasonable Efforts to negotiate a pharmacovigilance agreement (the “Pharmacovigilance Agreement”) to govern cooperation among the Parties together with


  
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CIS II and AIS that will enable each of them to comply with its respective obligations under applicable Laws and to satisfy its duty of care with respect to the Licensed Products, including with
regard to ownership of the Global Safety Database, adverse event data collection, analysis and reporting. The Pharmacovigilance Agreement will be entered among the Parties together with CIS II and AIS no later than the completion of the first Phase
I Study of a Licensed Product. 
 Section 5.4 Recalls, Market Withdrawals or Corrective Actions. 

(a) In the event that any Regulatory Authority issues or requests a recall, market withdrawal or similar action in connection with a Licensed
Product in any portion of the US Territory, or in the event either Party determines that an event, incident or circumstance has occurred that may result in the need for a recall, market withdrawal or similar action in any portion of the US
Territory, the Party notified of such recall, market withdrawal or similar action, or the Party that desires such recall, market withdrawal or similar action, shall within [**] hours advise the other Party thereof by telephone or facsimile. The JSC
shall decide whether to conduct a recall, market withdrawal or similar action in any portion of the US Territory and the manner in which any such recall, market withdrawal or similar action shall be conducted. Each Party will make available to the
other Parties, upon request, all of such Party’s (and its Affiliates’) pertinent records that such other Party may reasonably request to assist such other Party in effecting any recall, market withdrawal or similar action. 

(b) The costs and expenses incurred before the Agios Opt-Out Date relating to a recall, market withdrawal or similar action of any Licensed
Product(s) in the US Territory shall be taken into account in determining US Territory Profit or Loss as, and to the extent, provided in the Financial Exhibit. The costs and expenses incurred after the Agios Opt-Out Date for any recall, market
withdrawal or similar action of any Licensed Product(s) in the US Territory shall be borne solely by Celgene if and only to the extent (i) such recall, market withdrawal or similar action was caused by the occurrence after the Agios Opt-Out
Date of the event, incident or circumstance that led to the recall, market withdrawal or similar action and (ii) the event, incident or circumstance and the costs and expenses for such recall, market withdrawal or similar action are not the
subject of an indemnity obligation of Agios under Section 13.2. The costs and expenses incurred after the Agios Opt-Out Date relating to any recall, market withdrawal or similar action of any Licensed Product(s) in the US Territory shall be
borne fifty per cent (50%) by each of the Parties to the extent (A) such recall, market withdrawal or similar action was caused by the occurrence before the Agios Opt-Out Date of the event, incident or circumstance that led to the recall,
market withdrawal or similar action and (B) such event, incident or circumstance and such costs and expenses are not the subject of an indemnity obligation of either Party under Section 13.1 or 13.2. If Agios is invoiced for its portion of
such costs and expenses incurred after the Agios Opt-Out Date, payment is due within [**] days of receipt of invoice. 
 Article VI

 Commercialization 

Section 6.1 Commercialization Responsibilities for Licensed Products. 

(a) Responsibility. Subject to oversight by the JCC and to Sections 2.8, 2.12 and 6.3(f), each Party shall have the responsibility for
the Commercialization of Licensed Products in the US Territory as specified in the Commercialization Plan. 

  
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 (b) Effects on Licensed Product and “Licensed Products” Under 2010 Agreement. If
(i) either Party or its Affiliate (the “Proposing Party”) proposes to take or take(s) any Commercialization action (or make any business decision) that is not contemplated by the Commercialization Plan in effect at such time,
that the other Party (the “Objecting Party”) reasonably determines is reasonably likely to have a material adverse impact on the Commercialization of any of the “Licensed Products,” as such term is defined in the 2010
Agreement or (ii) Agios or its Affiliate proposes to take any such action that Celgene or its Affiliate reasonably determines is reasonably likely to have an adverse impact on Commercialization of the “Licensed Products,” as such term
is defined in the AGI-23088 ROW Agreement, in the ROW Territory, such Objecting Party (and its Affiliate, if applicable) shall provide written notice to such effect to the Proposing Party specifying in
reasonable detail which actions by such Proposing Party or its Affiliates would have such an effect, and what such effect would be. The Parties shall use good faith efforts to discuss the pertinent actions and resolve the matter. If the Proposing
Party concurs with the Objecting Party’s determination, the Proposing Party and its Affiliates shall not proceed with, or shall cease as quickly as reasonably possible, as applicable, such action without the written consent of the Objecting
Party. If the Proposing Party does not concur with the Objecting Party’s determination, the Objecting Party may present the issue to the Executive Officers for resolution pursuant to Section 15.1(a) and, if agreement is not reached, may
seek resolution of such matter in accordance with Section 15.1(b). If the Objecting Party does present the issue to the Executive Officers for resolution, then Proposing Party and its Affiliates shall not proceed with, or shall cease as quickly
as reasonably possible, as applicable, such action until the dispute is resolved by agreement of the Executive Officers or in accordance with Section 15.1(b). 

(c) Sales. Celgene will book all sales of the Licensed Products in the US Territory and will have the sole responsibility for the
processing of orders, invoicing, terms of sale, and distribution of the Licensed Products throughout the Territory associated therewith. 

Section 6.2 Commercialization Plan. 

(a) Initial Commercialization Plan. 

(i) Subject to Sections 2.8 and 2.12, Commercialization of Products shall be governed by a Commercialization Plan (the
“Commercialization Plan”) that describes the Commercialization activities (including pre-launch and launch activities, if applicable) to be undertaken with respect to the Licensed Products in the US Territory, which shall include an
[**] budget of Commercialization Expenses (“Commercialization Budget”) and anticipated timelines for performance. 
 (ii)
Commencing no later than [**] months prior to the anticipated commercial launch of the first Licensed Product in the US Territory and thereafter at least [**] days prior to the start of each Calendar Year, Agios shall prepare the initial
Commercialization Plan for each Licensed Product, with input and guidance from the JDC, JCC and the Finance Working Group. Such Commercialization Plan shall describe Commercialization activities to be undertaken by the Parties in the US Territory.


  
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 (b) JCC Approval; Amendments. The JCC shall approve the first Commercialization Plan for
each Licensed Product no later than [**] prior to the anticipated commercial launch of each such Licensed Product in the US Territory. Thereafter, the JCC shall review the Commercialization Plan not less frequently than [**] and shall propose
updates to the Commercialization Plan for [**]. Either Party may also develop and submit to the JCC for review from time to time other proposed amendments to the applicable Commercialization Plan. The initial Commercialization Plan, and any
amendments and updates to the Commercialization Plan, shall be effective upon the approval of the JCC (subject to resolution of any dispute involving such approval as provided in Section 2.8). 

Section 6.3 Field-Based Marketing Activities. 

(a) General. The JCC shall determine the type and scope of field-based marketing efforts to be used for Commercialization of each
Licensed Product in the US Territory (e.g., sales force (and the number of physicians to be called on and call frequency), field-based medical affairs, advertising, and field-based market access
resources) (collectively, “Marketing Activities”), and the Commercialization Plan for each Licensed Product in the US Territory shall set forth such Marketing Activities for each Indication which is marketed in the US Territory.

 (b) Allocation of Activities. The Commercialization Plan will allocate to each Party its portion of the total Marketing Activities
for each Licensed Product in the US Territory; provided that, unless otherwise agreed to by the Parties, each Party will be allocated fifty percent (50%) of the Marketing Activities in the US Territory, wherein such percentages
refer to the total number of FTEs devoted to an activity when applicable. The Commercialization Plan will attempt to provide that Marketing Activities are distributed geographically within the US Territory in a manner reasonably consistent with the
distribution of the population in the US Territory and that each Party’s detailing effort, if applicable, will be directed to physicians of similar prescribing potential but shall take into account the competitive situation of the Licensed
Product. In overseeing the Marketing Activities, the JCC will take into account the Licensed Product’s customer base and call volume measured against the customer base, geographic scope of activities, and the competitive market for the Licensed
Product. 
 (c) Sales Force. To the extent the Marketing Activities include detailing efforts, the JCC shall determine the number of
sales representatives needed to carry out the required Marketing Activities in the US Territory for each Licensed Product. Each Party, in its sole discretion, shall create a field management structure for its sales effort. Each Party shall use
Commercially Reasonable Efforts to have hired, no later than [**] months before the applicable PDUFA date, the full sales force planned to be available for the launch of the Licensed Products in the US Territory and to have the sales force trained
within [**] months of hiring. Each sales representative shall have a sales territory that allows such sales representative to perform a reasonable number of details within a reasonable geographic area (i.e., without overly-burdensome travel
requirements but avoiding sales representatives detailing the same persons). The effort of the Agios and Celgene sales forces in promoting the Licensed Products 

  
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will be organized under the supervision of the JCC as to qualifications of sales representatives and field-based sales managerial personnel and the timing of hiring in light of the then-current
Commercialization Plan; provided that the Commercialization Plan shall identify the portion of the detailing effort to be undertaken by each Party in the US Territory no later than [**] months before the planned date of the NDA
submission in the US Territory. 
 (d) Training Materials and Sessions. The JCC will develop product-specific training materials and
arrange for provision of such materials to each Party’s sales forces, if applicable, for use in the US Territory. The JCC will develop a sales training program directed towards the Licensed Products use in the US Territory. Unless otherwise
mutually agreed by the Parties, Celgene and Agios sales representatives will participate in a launch meeting(s) (which may be held together or separately) for each Licensed Product, which shall include training sessions of product-specific sales
skills with respect to the approved Indications for the Licensed Products. Subsequent to launch, Celgene and Agios shall periodically hold meetings with Agios and Celgene field management (down to and including district managers or their equivalents
who are directly supervising territory sales representatives) to coordinate promotion of the Licensed Products in the US Territory. As requested by Agios, Celgene shall make its management, marketing, training and other personnel reasonably
available to participate in Agios’ national and regional sales meetings and Licensed Product training events for the US Territory. 

(e) Other Obligations. Subject to Section 2.12, in conducting the Marketing Activities in the US Territory, the Parties will
comply with all applicable Laws, applicable industry professional standards and compliance policies of Celgene, and, subject to Section 6.3(f), Agios, that have been previously furnished to the other Party, as the same may be updated from time
to time and provided to the other Party and not in violation of any applicable Law. Each Party will reasonably assist the other Party in training sales representatives in such standards. Neither Party shall make any claims or statements with respect
to the Licensed Products that are not strictly consistent with the product labeling and the sales and marketing materials approved for use pursuant to the Commercialization Plan or otherwise approved by the JCC. 

(f) Termination of Marketing Activities. Agios shall have the right to terminate its Marketing Activities obligations in the US
Territory with respect to any Licensed Product by providing at least [**] months’ prior written notice to Celgene (or sooner as Celgene may determine, in its sole discretion). Upon exercise of such termination right, effective upon the
expiration of such [**]-month (or, if applicable, shorter) notice period, Agios’ obligations to perform Marketing Activities under this Section 6.3 in the US Territory shall terminate, and
Celgene’s obligation under the first sentence of Section 6.3(e) to comply with Agios compliance policies, shall terminate (but, for clarity, Celgene’s other obligations under such first sentence shall not terminate). Further, if Agios
exercises this right with respect to the US Territory, then Celgene shall have final decision-making authority over all matters regarding Commercialization with respect to the US Territory. 

Section 6.4 Trademarks. 

(a) Selection of Trademarks. The JCC shall select the trademark(s) to be used in connection with the marketing and sale of the Licensed
Products in the US Territory (such marks, together will registrations, applications for registration and common law rights therein, collectively, “Product Trademarks”). Any dispute over the selection of a Product Trademarks
shall be presented to the JSC for resolution. The Parties shall adhere to the use of the Product Trademark(s) in their Commercialization of the Licensed Products in the US Territory hereunder, to the extent permitted by Law. 

  
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 (b) Ownership. Agios shall own all Product Trademarks for any Licensed Product in the US
Territory. Effective as of the Agios Opt-Out Date, Agios hereby assigns to Celgene all right, title and interest in and to the Product Trademarks in the US Territory free and clear of any liens and encumbrances. Agios will execute and deliver any
further document reasonably requested by Celgene to further document or record such assignment. 
 (c) Agios Acknowledgement and
License. In connection with all packaging, literature, labels and other printed matters used in the US Territory, to the extent permitted by Law, the Parties shall include an expression to the effect that the Licensed Products were developed
under license from Agios, together with the Agios logo. Agios hereby grants Celgene a license to use Agios’ name and logo to comply with such obligation and in the Product Trademarks for the US Territory as reasonably required for Celgene to
exercise its rights and perform its obligations under this Agreement in the US Territory. 
 Article VII 

Diligence 

Section 7.1 Collaboration Activities. 

(a) General. Each Party shall use Commercially Reasonable Efforts to perform all Development, Manufacturing and Commercialization
activities for which such Party is responsible hereunder in compliance with the applicable Development Plan or Commercialization Plan, including any budget(s) and timeframe(s) set forth therein and including making available those resources set
forth in any applicable Development Plan or Commercialization Plan, and the terms of this Agreement. 
 (b) Compliance with Laws.
Each Party shall: 
 (i) perform its obligations under this Agreement in a scientifically sound and workmanlike manner; and 

(ii) carry out all work done in the course of the Collaboration in compliance with all applicable Laws governing the conduct of such work.

 Section 7.2 Diligence Obligations. 

(a) In addition to the diligence obligations set forth in Section 7.1, the Parties shall use Commercially Reasonable Efforts to Develop
and achieve Regulatory Approval for the Licensed Products in each of the Major Markets and, following such Regulatory Approval, to Commercialize such Licensed Products in each of the Major Markets. 

(b) A breach of the diligence obligations set forth in this Section 7.2 shall be deemed a material breach and shall be subject to
termination under Section 14.2(b)(i). Notwithstanding the foregoing, the Parties acknowledge that it might be commercially reasonable, under certain circumstances, for the Party having lead responsibility for Marketing Activities in any portion
of the Major Markets to determine not to launch a Licensed Product in [**] Major Markets, and failure under such circumstances to launch such Licensed Product shall not be a breach of this Agreement. 

  
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 Section 7.3 Day-to-Day Responsibility. Each Party shall be responsible for day-to-day
implementation of the Development, Manufacturing Commercialization activities for which it (or its Affiliate) has or otherwise is assigned responsibility under this Agreement or the applicable Development Plan or Commercialization Plan and shall
keep the other Party reasonably informed as to the progress of such activities, as determined by the JDC and JCC. 
 Article VIII 

Grant of Rights; Exclusivity 

Section 8.1 License Grants. Subject to the terms and conditions of this Agreement: 

(a) Licenses Granted to Celgene. Agios hereby grants to Celgene a non-transferable (except as set forth in Section 15.4), right
and license in the Field, with the right to grant sublicenses as set forth in Sections 8.2(a) and 8.2(b), under Agios’ rights in Agios Intellectual Property and Agios Collaboration Intellectual Property, to Develop, Manufacture and/or
Commercialize Licensed Products in the US Territory. Such license is a Sole license until the Agios Opt-Out Date; upon and after the Agios Opt-Out Date, such license automatically converts to an exclusive license (including exclusive of Agios and
its Affiliates). 
 (b) Licenses Granted to Agios. Celgene hereby grants to Agios a Sole, non-transferable (except as set forth in
Section 15.4), right and license in the Field, with the right to grant sublicenses as set forth in Sections 8.2(a) and 8.2(b), under Celgene’s rights in Celgene Intellectual Property and Celgene Collaboration Intellectual Property, to
Develop, Manufacture and/or Commercialize Licensed Products in the US Territory. 
 Section 8.2 Sublicense Rights. Subject to
Section 8.3, the Parties have the following sublicensing rights. 
 (a) Sublicenses to Affiliates and Subcontractors. Each Party
shall have the right to grant sublicenses within the scope of the licenses and sublicense under Section 8.1: 
 (i) to such
Party’s Affiliates; and 
 (ii) to Third Parties for the purpose of engaging Third Parties as contract research organizations,
contract manufacturers, contract sales forces, consultants, academic researchers and the like (“Third Party Contractors”) in connection with Development, Manufacturing or Commercialization activities on behalf of such Party or its
Affiliates with respect to the Collaboration under this Agreement, subject to the following: 
 (A) unless otherwise agreed by the JSC by
Mutual Consent, each Party shall require any such Third Party to whom such Party discloses Confidential Information to enter into an appropriate written agreement obligating such Third Party to be bound by obligations of confidentiality and
restrictions on use of such Confidential Information that are no less restrictive than the obligations set forth in Article XI, including requiring such Third Party to agree in writing not to issue any Publications except in compliance with the
terms of this Agreement (including approval by the JDC or JCC, as applicable, pursuant to the approved publication plan, and the obligations set forth in Section 11.4, except that Publications by academic collaborators shall be permitted
(without JDC or JCC consent, as applicable) if the academic collaborator (i) provides an advance copy of the proposed Publication (under the same time periods as described in Section 11.4(a)), which may be shared with the other Party,
(ii) agrees to delay such Publication sufficiently long enough to permit the timely preparation and filing of a patent application, and (iii) upon the request of either Party, removes from such Publication any Confidential Information of
such Party); 

  
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 (B) unless otherwise agreed by the JSC by Mutual Consent, each Party will obligate such Third
Party to agree in writing to [**] to, any inventions arising under its agreement with such Third Party to the extent related to Development, Manufacturing or Commercialization with respect to the Licensed Products in the Field in the US Territory;
and such Party shall structure such [**] so as to enable such Party to sublicense such Third Party inventions to the other Party pursuant to Section 8.1 (including permitting such other Party to grant further sublicenses); provided
that, in connection with any academic collaborator performing research work to research either or both of the Targets, each Party will only be required to obligate such academic collaborator to agree in writing to grant [**] to, and a right
to negotiate for [**] to, any such inventions, which must be sublicensable to the other Party pursuant to Section 8.1 (including permitting such other Party to grant further sublicenses); 

(C) each Party shall notify the JDC or JCC, as applicable, at a regular meeting of the JDC or JCC, as applicable, of the execution any such
agreement with such Third Party and, if requested, shall provide the other Party with a copy of such agreement, which copy may be redacted with respect to matters that do not relate to the Collaboration; and 

(D) unless otherwise agreed by the JSC by Mutual Consent, each Party will require any such Third Party to grant to the other Party access to
[**] generated by such Third Party’s work with respect to the Licensed Products to the same extent as such other Party’s licenses under Section 8.1, and grant the other Party the right to audit the records of such Third Party. 

(b) Other Sublicenses. Except as provided in Section 8.2(a), any sublicense by either Party under the licenses and sublicense set
forth in Section 8.1 shall require the prior written approval of the other Party. 
 Section 8.3 Sublicense Requirements.
Any sublicense granted by a Party pursuant to this Agreement shall be subject to the following: 
 (a) each sublicense granted hereunder by
a Party shall be consistent with the requirements of this Agreement; 

  
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 (b) any transfer of rights between a Party and its Affiliates shall not be deemed a sublicense by
such Party but shall be deemed a direct license by the other Party to such Party’s Affiliate; provided that such Party shall remain responsible for the activities of its Affiliate; 

(c) a Party’s or its Affiliates’ Third Party sublicensees shall have no right to grant further sublicenses without the other
Party’s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed; 
 (d) such Party shall be
primarily liable for any failure by its sublicensees to comply with all relevant restrictions, limitations and obligations in this Agreement; 

(e) such sublicense must be granted pursuant to a written sublicense agreement and, with respect to any sublicense other than a sublicense by
a Party to an Affiliate of such Party, such Party must provide the other Party with a copy of any sublicense agreement entered into under Section 8.2 above within [**] days after the execution of such sublicense agreement; provided
that any such copy may be redacted to remove any confidential, proprietary or competitive information, but such copy shall not be redacted to the extent that it impairs the other Party’s ability to ensure compliance with this Agreement.
Such sublicense agreement shall be treated as Confidential Information of the sublicensing Party; and 
 (f) except as otherwise provided in
the sublicense agreement, if this Agreement terminates for any reason, any Third Party sublicensee of a Party shall, from the effective date of such termination, automatically become a direct licensee of the other Party with respect to the rights
licensed to such Party hereunder and sublicensed to the sublicensee by such Party; provided, however, that such sublicensee is not in breach of its sublicense agreement and continues to perform thereunder. 

Section 8.4 Affiliates and Third Party Contractors. Either Party may exercise its rights and perform its obligations hereunder
itself or through its Affiliates and sublicensees. Each Party shall be primarily liable for any failure by its Affiliates and sublicensees (including Third Party Contractors) to comply with all relevant restrictions, limitations and obligations in
this Agreement. If either Party desires to use any Person to conduct any of its Development, Commercialization or other Collaboration activities hereunder, such Party must comply with the obligations of Section 8.2(a)(ii)(A) through (D), even
to the extent no sublicense of rights is granted to such Third Party. 
 Section 8.5 Existing Third Party Agreement. 

(a) Acknowledgement. Except as provided in Section 8.5(b), Agios acknowledges that it is responsible for the fulfillment of its
obligations under the Existing Third Party Agreement and agrees to fulfill the same, including any provisions necessary to maintain in effect any rights sublicensed to Celgene hereunder and the exclusive nature of such rights, subject to
Celgene’s compliance with its obligations hereunder. In the event of any conflict between the terms of this Agreement and the Existing Third Party Agreement, the Parties will discuss in good faith how to address the conflict; provided
that, if the Parties are unable to agree on how to address the conflict, the terms of this Agreement shall govern. 

  
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 (b) Incorporation of Certain Provisions. Celgene acknowledges and agrees that it shall be
bound by the following provisions of the Existing Third Party Agreement, as a sublicensee of the rights licensed to Agios thereunder but only to the extent applicable to the rights sublicensed to Celgene hereunder: Sections 1.3 (as described in
Section 8.7(b) hereof), 2.1, 2.3, 5.2, 5.3, 5.4, 5.5, 6.2, 7.1, 8.1 (with respect to information of the licensors under the [**] Agreement or with respect to the licensors’ obligation to keep information of either Party confidential), 10.1
and 10.4 of the [**] Agreement. Furthermore, Celgene acknowledges that Agios is required to share certain reports and copies of sublicense agreements provided by Celgene to Agios hereunder with the licensors under the Existing Third Party Agreement,
and Celgene consents to the sharing of such reports and such copies of such sublicense agreements to the extent required under such Existing Third Party Agreement to the same extent as disclosures are permitted under Section 11.3(b)(ii)(B)
hereunder; provided that any such copies of sublicense agreements must be redacted to the extent permitted under such Existing Third Party Agreement. 

(c) Covenants Regarding the Existing Third Party Agreement. Agios agrees that during the Term: 

(i) Agios shall not modify or amend the Existing Third Party Agreement in any way without Celgene’s prior written consent; 

(ii) Agios shall not terminate the Existing Third Party Agreement, in whole or in part, without Celgene’s prior written consent; 

(iii) Agios shall be solely responsible for, and shall make, all royalty payments, milestone payments, yearly fees, sublicensee fees,
Prosecution fees, and all other payments owed to the licensors under and pursuant to the Existing Third Party Agreement; 
 (iv) Agios
shall not exercise or fail to exercise any of Agios’ rights, or fail to perform any of Agios’ obligations, under the Existing Third Party Agreement that relate to Celgene’s rights hereunder without the prior written consent of
Celgene, including rights with respect to including improvements within the licenses granted under the Existing Third Party Agreement; and, at the reasonable request of Celgene, Agios shall exercise such rights and make such requests that relate to
Celgene’s rights hereunder as are permitted under the Existing Third Party Agreement; 
 (v) Agios shall promptly furnish Celgene with
copies of all reports and other communications that Agios furnishes to the licensors under the Existing Third Party Agreement to the extent that such reports relate to this Agreement; 

(vi) Agios shall promptly furnish Celgene with copies of all reports and other communications that Agios receives from the licensors under
the Existing Third Party Agreement that relate to the subject of this Agreement (including notices relating to improvements under the Existing Third Party Agreement); 

(vii) Agios shall furnish Celgene with copies of all notices received by Agios relating to any alleged breach or default by Agios under the
Existing Third Party Agreement within [**] Business Days after Agios’ receipt thereof; in addition, if Agios should at any time breach the Existing Third Party Agreement or become unable to timely perform its obligations thereunder, Agios shall
immediately notify Celgene; 

  
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 (viii) If Agios cannot or chooses not to cure or otherwise resolve any alleged breach or default
under the Existing Third Party Agreement, (A) Agios shall so notify Celgene within [**] Business Days of such decision, which shall not be less than [**] Business Days prior to the expiration of the cure period under the Existing Third Party
Agreement; provided that Agios shall use Commercially Reasonable Efforts to cure any such breach or default; and (B) Celgene, in its sole discretion, shall be permitted (but shall not be obligated), on behalf of Agios, to cure any
breach or default under the Existing Third Party Agreement in accordance with the terms and conditions of the Existing Third Party Agreement or otherwise resolve such breach directly with the licensors under the Existing Third Party Agreement; and
(C) if Celgene pays any such licensor any amounts owed by Agios under the Existing Third Party Agreement, Celgene may deduct such amounts from payments Celgene is required to make thereafter to Agios hereunder or, at Celgene’s election,
may otherwise seek reimbursement of such amounts from Agios; and 
 (ix) Agios shall not provide any Licensed Products to the licensors
under the Existing Third Party Agreement without Celgene’s prior written consent. 
 (d) Survival of Celgene’s Rights Following
Termination of Existing Third Party Agreement. The Parties agree that in the event of any termination of the Existing Third Party Agreement with respect to any intellectual property rights licensed to Celgene hereunder, Celgene shall have any
rights available under such Existing Third Party Agreement to become a direct licensee of the Third Party licensors under such Existing Third Party Agreement and Agios shall use Commercially Reasonable Efforts to assist Celgene in exercising such
rights; provided that Celgene has not breached this Agreement, or breached the applicable Third Party Rights under such Existing Third Party Agreement. In addition, notwithstanding the foregoing, in the event of such termination,
Celgene may in any event approach the licensors under the Existing Third Party Agreement for a direct license. In the event of any such direct license following any termination of the Existing Third Party Agreement without Celgene’s consent,
Celgene shall be entitled to deduct from any payments owed to Agios hereunder [**] percent ([**]%) of the amounts paid by Celgene to such licensor under such direct license with respect to licenses within the scope of the licenses previously granted
to Agios under the Existing Third Party Agreement. 
 (e) Termination of Existing Third Party Agreement. The Parties agree that
termination, without Celgene’s prior written consent, of the Existing Third Party Agreement with respect to any Patent Right or Know-How that is necessary to Develop, Manufacture or Commercialize the Licensed Products shall be deemed a material
breach of this Agreement by Agios; provided that (i) if Celgene’s breach of this Agreement results in a breach of the Existing Third Party Agreement, Celgene agrees to use Commercially Reasonable Efforts to assist Agios in
curing such breach of the Existing Third Party Agreement, and (ii) if Celgene’s breach of this Agreement results in a termination of the Existing Third Party Agreement, such termination of the Existing Third Party Agreement shall not be
deemed a material breach by Agios of this Agreement or AIS of the AGI-23088 ROW Agreement. 

  
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 Section 8.6 Exclusivity. 

(a) Agios Exclusivity Obligations. During the Term, Agios and, subject to Sections 15.4(b) and 15.4(c), its Affiliates shall not,
directly or indirectly, Develop, Manufacture or Commercialize any therapeutic modality (including any small molecule or biologic) in any field or application that [**], except for the following: 

(i) Licensed Products pursuant to the Collaboration under this Agreement (including those activities specifically permitted upon and after
termination); 
 (ii) Collaboration Compounds, Development Candidates, Licensed Compounds, Independent Compounds and products that contain
any of the foregoing pursuant to the 2010 Agreement (as such terms are defined in the 2010 Agreement); and 
 (iii) Agios Reverted
Compounds (other than Agios Reverted Compounds that [**]) and Agios Reverted Products that contain any such Agios Reverted Compound, in each case pursuant to the 2010 Agreement (as such terms are defined in the 2010 Agreement). 

(b) Celgene Exclusivity Obligations. During the Term, Celgene and, subject to Sections 15.4(b) and 15.4(c), its Affiliates shall not,
directly or indirectly, Develop, Manufacture or Commercialize any therapeutic modality (including any small molecule or biologic) in any field or applications that [**], except for the following: 

(i) Licensed Products pursuant to this Agreement (including those activities specifically permitted upon and after termination); and 

(ii) Collaboration Compounds, Development Candidates, Licensed Compounds, Independent Compounds, Celgene Reverted Compounds and products that
contain any of the foregoing in each case pursuant to the 2010 Agreement (as such terms are defined in the 2010 Agreement). 
 (c)
Exception. A Party shall not be deemed to be, directly or indirectly, Developing, Manufacturing or Commercializing in violation of the provisions of Section 8.6(a) or 8.6(b) as a result of conducting a research program or discovery
effort (or manufacturing or commercializing a therapeutic modality resulting from such research program or discovery effort) that has as its specified and primary goal, as evidenced by laboratory notebooks or other relevant documents
contemporaneously kept, taken as a whole, to discover or Develop compounds that [**], as applicable, that are subject to the prohibitions of Section 8.6(a) or 8.6(b). 

(d) Celgene Exception. It is agreed and understood by the Parties that any Celgene research, discovery and commercialization activities
existing as of the effective date of the 2010 Agreement, whether such activities are undertaken by Celgene alone or in conjunction with one or more partners, licensors, licensees, and/or collaborators, are expressly excluded from the provisions of
this Section 8.6. In particular and without limitation, Celgene research, discovery, and commercialization activities related to (i) the [**]; (ii) the [**]; (iii) [**]; (iv) [**]; (v) [**]; or (vi) [**]. 

  
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 Section 8.7 Retained Rights. 

(a) No Implied Licenses or Rights. Except as expressly provided in Section 8.1, and subject to Section 8.6, all rights in and
to the Agios Intellectual Property, Agios’ and its Affiliates’ interests in Agios Collaboration Intellectual Property and any other Patent Rights or Know-How of Agios and its Affiliates, are hereby retained by Agios and its Affiliates.
Except as expressly provided in Sections 8.1, and subject to Section 8.6, all rights in and to the Celgene Intellectual Property, Celgene’s and its Affiliates’ interests in Celgene Collaboration Intellectual Property and any other
Patent Rights or Know-How of Celgene and its Affiliates, are hereby retained by Celgene and its Affiliates. 
 (b) Other Retained
Rights. The Parties acknowledge that the licenses granted hereunder are subject to the rights retained by the licensors under the [**] Agreement pursuant to Sections 1.3 and 2.3 of the [**] Agreement; provided that, upon
Celgene’s reasonable request, Agios shall cooperate fully in requesting and obtaining any waiver with respect to the requirement, if applicable under such agreements, that the Licensed Products used or sold in the United States be manufactured
substantially in the United States. 
 Section 8.8 Section 365(n) of the Bankruptcy Code. All rights and licenses granted
under or pursuant to any section of this Agreement are and will otherwise be deemed to be for purposes of Section 365(n) of the United States Bankruptcy Code (Title 11, U.S. Code), as amended (the “Bankruptcy Code”), licenses
of rights to “intellectual property” as defined in Section 101(35A) of the Bankruptcy Code. The Parties will retain and may fully exercise all of their respective rights and elections under the Bankruptcy Code. The Parties agree that
each Party, as licensee of such rights under this Agreement, will retain and may fully exercise all of its rights and elections under the Bankruptcy Code or any other provisions of applicable law outside the United States that provide similar
protection for “intellectual property.” The Parties further agree that, in the event of the commencement of a bankruptcy proceeding by or against a Party under the Bankruptcy Code or analogous provisions of applicable Law outside the
United States, the Party that is not subject to such proceeding will be entitled to a complete duplicate of (or complete access to, as appropriate) such intellectual property and all embodiments of such intellectual property, which, if not already
in the non-subject Party’s possession, will be promptly delivered to it upon the non-subject Party’s written request thereof. Any agreements supplemental hereto will be deemed to be “agreements supplementary to” this Agreement
for purposes of Section 365(n) of the Bankruptcy Code. 
 Article IX 

Financial Provisions 

Section 9.1 Initial Payment. In consideration of Agios’ discovery of AG-23088 and the rights and licenses granted hereunder,
Celgene shall make an initial, non-refundable payment to Agios of [**] Dollars (US $[**]) within [**] days following the Effective Date. 

  
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 Section 9.2 Development Costs. 

(a) Sharing of Development Costs. Subject to Section 2.12: 

(i) The Development Costs to be shared by the Parties under this Agreement and the parties to the AGI-23088 ROW Agreement are those
(A) Development Costs that are incurred after the IND Acceptance Date and (B) Manufacturing Costs associated with clinical supply of Licensed Products (even if incurred before the Effective Date), and, in either case, that are within [**]
percent ([**]%) of the approved Development Budget under the Development Plan. Any Development Costs in excess of [**] percent ([**]%) of the approved Development Budget under the Development Plan shall be borne solely by the Party incurring such
costs unless such Party has received the other Party’s written approval to share such excess costs. The Parties have determined the reasonably anticipated benefits share for purposes of Section 482 of the Code between the US Territory and
ROW Territory to be derived from the Development activities and as a result each Party agrees to have it and its Affiliates allocate [**] percent ([**]%) of the Development Costs to the US Territory under this Agreement and the remainder of their
portion of the Development Costs to the ROW Territory under the AGI-23088 ROW Agreement. Each Party shall be responsible for fifty percent (50%) of the Development Costs allocated to this Agreement. 

(ii) Within [**] days following the beginning of the [**], each Party shall prepare and deliver to the Finance Working Group a [**] report
detailing its and its Affiliates’ Development Costs incurred during the first [**], estimated to be incurred during the [**], and actually incurred in the [**] which are required to be shared pursuant to this Section 9.2. Each Party shall
submit any supporting information or clarifications reasonably requested by the other Party related to such Development Costs included in such Party’s report within [**] days after the other Party’s receipt of such request. The Parties,
with the assistance of the Finance Working Group, shall conduct a reconciliation of Development Costs for the subject [**] within [**] days after receipt of all such supporting information, and an invoice shall be issued to the Party (if any) that
has not paid for its full share of the Development Costs for such [**]. Such reconciliation shall balance the actual amount of Development Costs incurred during the [**] (to correct for any differences between the estimates and actual amount of such
costs) together with the amounts incurred during the first [**] and those estimated to be incurred during the [**]. The paying Party shall pay all amounts payable under any such invoice within [**] days after its receipt of such invoice. 

(b) Annual Cost Cap. In the event that Agios’ share of aggregate Development Costs in any given Calendar Year, including any such
Development Costs that become due from Agios pursuant to Section 3.3(d) or 3.3(e) in such Calendar Year, plus Agios’ share of US Territory Loss and AIS’s share of ROW Territory Loss (as defined in the AGI-23088 ROW Agreement) for any
Calendar Quarter in such Calendar Year, less Agios’ share of US Territory Profit (if any) and AIS’s share of ROW Territory Profit (if any) (as defined in the AGI-23088 ROW Agreement) for any Calendar Quarter in such Calendar Year, exceed a
total of $[**], then any such amounts for such Calendar Year that are in excess of $[**] (the “Excess Amounts”) shall be borne initially by Celgene and CIS II, and not by Agios or AIS, and the reimbursement calculations set forth in
Section 9.2(a) for such Calendar Year shall be adjusted accordingly with [**] percent ([**]%) of the Excess Amount being applied under this Agreement and [**] percent ([**]%) of the Excess Amounts being applied to the AGI-23088 ROW Agreement
(and the reimbursement calculations in Section 9.2(a) of the AGI-230889 ROW Agreement) also being adjusted accordingly. Celgene may recoup the [**] percent ([**]%) of the Excess Amounts due under this Agreement, together with interest thereon


  
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calculated at the rate set forth in Section 9.11, calculated on the number of days from the date on which Agios’ payment of such Excess Amounts would otherwise be due to Celgene if this
Section 9.2(b) did not apply until the date reimbursed to Celgene, from any milestone payments owed under Section 9.3 and Agios’ share of US Territory Profits (if any) and AIS’s share of ROW Territory Profits (if any) (as defined
in the AGI-23088 ROW Agreement) in the Calendar Year in which the Excess Amounts accrued or thereafter until such Excess Amounts and applicable interest have been fully recouped (and the other [**] percent ([**]%) of such Excess Amounts, together
with interest, will be recouped as provided in the AGI-23088 ROW Agreement). Excess Amounts and interest thereon shall be reimbursable only from such milestone payments and Agios’ share of US Territory Profits (if any) and AIS’s share of
ROW Territory Profits (if any) (as defined in the AGI-23088 ROW Agreement), and shall not otherwise be owed from Agios to Celgene; provided, however, that in the event that the Development and Commercialization of all Licensed
Products are permanently discontinued by Mutual Consent or this Agreement is terminated for any reason, then all Excess Amounts due under this Agreement shall be paid by Agios to Celgene in equal annual installments over the next [**]. Agios may in
its discretion elect to pre-pay any portion of outstanding Excess Amounts or associated interest upon written notice to Celgene. 

Section 9.3 Milestone Payments. Celgene shall pay Agios the following amounts after the first achievement by or on behalf of the
Parties or their respective Affiliates or sublicensees of the corresponding milestone events set forth below with respect to the first Licensed Product to achieve such milestone events. 

 

					
	 Milestones
	  	Amount	 
	 (1) Filing of first NDA in a Major Market, whether such NDA is filed in the US Territory pursuant to this Agreement or in the ROW
Territory pursuant to the AGI-23088 ROW Agreement
	  	US$	[**	] 
		
	 (2) First Regulatory Approval in any Major Market, whether such Regulatory Approval is obtained in the US Territory pursuant to this
Agreement or in the ROW Territory pursuant to the AGI-23088 ROW Agreement
	  	US$	[**	] 
		
	 (3) Second Regulatory Approval in any Major Market, but only if received in a different country or region, as applicable, than the
first Regulatory Approval, whether such Regulatory Approval is obtained in the US Territory pursuant to this Agreement or in the ROW Territory pursuant to the AGI-23088 ROW Agreement
	  	US$	[**	] 

 (a) For purposes of determining the occurrence of milestones under item (1) in the table above, [**]
shall be deemed to have occurred [**] days following [**]; provided that, if such [**]. For purposes of determining the occurrence of milestones under items (2) and (3) in the table above, the [**]. For purposes of clarity,
no milestone amount shall be payable to Agios under item (3) if [**] for purposes of item (3). 

  
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 (b) Each milestone payment under this Section 9.3 shall be made within [**] days after the
achievement of the applicable milestone by Celgene or any of its Affiliates or sublicensees (or, if achievement of such milestone is within the control of Agios, within [**] days following Celgene’s receipt of written notice of the achievement
of such milestone). 
 (c) For clarity, (i) the milestone payments set forth in the table above in this Section 9.3 (to the extent
payable) shall be paid only once, regardless of the number of Licensed Products to achieve the applicable milestone event and regardless of the number of Indications for which the milestone event may be achieved and (ii) the milestone payments
set forth in the table above shall be in addition to any milestones payable pursuant to the AGI-23088 ROW Agreement. 
 Section 9.4
US Territory Profit or Loss. Subject to Section 2.12: 
 (a) Profit or Loss. The Parties shall share in US Territory
Profit or Loss as follows: Agios shall bear (and be entitled to) fifty percent (50%), and Celgene shall bear (and be entitled to) fifty percent (50%). Each Party may include Commercialization Expenses in the US Territory Profit or Loss incurred by
such Party that are within [**] percent ([**]%) of the approved Commercialization Budget under the Commercialization Plan. Any Commercialization Expenses in excess of [**] percent ([**]%) of the approved Commercialization Budget under the
Commercialization Plan shall be borne solely by the Party incurring such costs and not included in US Territory Profit or Loss unless such Party has received the other Party’s written approval to share such excess costs. 

(b) [**] Reconciliation and Payments. Unless the Parties otherwise agree, the Reconciliation Procedures shall provide that: 

(i) Within [**] days following the end of [**], each Party shall prepare and deliver to the Finance Working Group a [**] report detailing its
Net Sales made and Commercialization Expenses incurred, and other amounts necessary to calculate US Territory Profit or Loss, during such [**], with respect to which the Parties share US Territory Profit or Loss pursuant to this Section 9.4.
Each Party shall submit any supporting information reasonably requested by the other Party related to such Net Sales, Commercialization Expenses and such other amounts included in such Party’s reconciliation report within [**] days after the
other Party’s receipt of such request. The Parties, with the assistance of the Finance Working Group, shall conduct a reconciliation of US Territory Profit or Loss for the full [**] within [**] days after receipt of all such supporting
information, and an invoice shall be issued to the Party (if any) that owes the other Party a payment to accomplish the sharing of the US Territory Profit or Loss identified in such reconciliation for such [**]. The paying Party shall pay all
amounts payable under any such invoice within [**] days after its receipt of such invoice. 

  
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 Section 9.5 Royalty Payments Following Agios Opt-Out. In the event of an Agios
Opt-Out Date: 
 (a) Royalty Rate. Celgene shall pay to Agios royalties on Annual Net Sales of Licensed Products in the US Territory
(i) at the royalty rate of [**] percent ([**]%), if acceptance for review of the first NDA for a Licensed Product occurred prior to the Agios Opt-Out Date, or (ii) at the following rates, if acceptance for review of the first NDA for a
Licensed Product did not occur prior to the Agios Opt-Out Date: 
  

					
	 Annual Net Sales of Licensed Products
	  	Royalty Rate	 
	 On the tranche of Annual Net Sales in the US Territory occurring until aggregate, worldwide Annual Net Sales reaches US$[**]
	  	 	[**	]% 
		
	 On the tranche of Annual Net Sales in the US Territory occurring so long as aggregate, worldwide Annual Net Sales is equal to or
greater than US$[**] and less than US$[**]
	  	 	[**	]% 
		
	 On the tranche of Annual Net Sales in the US Territory occurring upon and after aggregate, worldwide Annual Net Sales equals
US$[**]
	  	 	[**	]% 

 (b) Royalty Term. Royalties payable under this Section 9.5 shall be paid by Celgene on a Licensed
Product-by-Licensed Product and country-by-country basis from the later of (i) the Agios Opt-Out Date and (ii) the date of First Commercial Sale of each Licensed Product in a country of the US Territory with respect to which royalty
payments are due, until the latest of: 
 (i) the last to expire of any Valid Claim of Agios Patent Rights or Agios Collaboration Patent
Rights (including Joint Patents), in each case Covering such Licensed Product in such country of the US Territory; 
 (ii) [**] years
following the date of First Commercial Sale in such country of the US Territory; and 
 (iii) the expiration of Regulatory Exclusivity for
such Licensed Product in such country of the US Territory; 
 (each such term with respect to a Licensed Product and a country, a “Royalty
Term”). 
 (iv) Notwithstanding the foregoing, (A) in the event that the Royalty Term for a Licensed Product in a country of
the US Territory continues solely due to Section 9.5(b)(ii) above (i.e., the Licensed Product is not Covered by a Valid Claim of Agios Patent Rights or Agios Collaboration Patent Rights in the applicable country, and such Licensed
Product is not subject to Regulatory Exclusivity in such country) or (B) in the event that, and for so long as, Generic Competition for a Licensed Product occurs in a country of the US Territory, then, in either such event, the royalty rate in
such country will be reduced to [**] percent ([**]%) of the applicable rate in Section 9.5(a) in such country. 
 (v) Upon the
expiration of the Royalty Term with respect to a Licensed Product in a country of the US Territory, the license granted by Agios to Celgene pursuant to Section 8.1(a) shall be deemed to be fully paid-up, irrevocable and perpetual with respect
to such Licensed Product in such country. 

  
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 (c) Deduction for Third Party Payments. In the event that royalties are payable by Celgene
to Agios with respect to any Licensed Product under this Section 9.5, Celgene shall have the right to deduct a maximum of [**] percent ([**]%) of any royalties or other amounts actually paid by Celgene to a Third Party from and after the Agios
Opt-Out Date (i) with respect to any license obtained prior to the Agios Opt-Out Date pursuant to Section 9.6(b)(i), and (ii) with respect to any other license obtained pursuant to Section 9.6(b) but only to the extent that the
Patent Rights and/or Know-How licensed under such other license are necessary (A) to use the Targets to which the applicable Licensed Product is directed or (B) to the Development, Manufacture or Commercialization of such Licensed Product
in a country(ies) in the US Territory, from royalty payments otherwise due and payable by Celgene to Agios under this Section 9.5 with respect to such Licensed Product in such country(ies), on a Licensed Product-by-Licensed Product and
country-by-country basis; provided, however, that in no event shall the aggregate deductions permitted by this Section 9.5(c) reduce the royalties payable by Celgene to Agios with respect to any such Licensed Product in such
country(ies) for any Calendar Quarter to less than [**] percent ([**]%) of the royalties otherwise due in the absence of any deduction pursuant to this Section 9.5(c); provided further that on a Licensed Product-by-Licensed
Product basis, any royalty deductions that are not credited against royalties for the Calendar Quarter in which they were accrued due to the limitation in the preceding proviso shall be carried forward and credited against royalties payable in
subsequent Calendar Quarter(s) hereunder until such royalty credits are completely expended. 
 (d) Royalty Reports; Payments. Within
[**] calendar days after the end of any [**] following the Agios Opt-Out Date, Celgene with respect to each Licensed Product shall provide Agios with a report stating the sales in units and in value of such Licensed Product made by Celgene, its
Affiliates, licensees and sublicensees, as applicable, in the US Territory, on a country-by-country basis, together with the calculation of the royalties due to Agios, including the method used to calculate the royalties, the exchange rates used,
and itemized deductions. Payments of all amounts payable under this Section 9.5 shall be made by Celgene to the bank account indicated by Agios concurrently with the delivery of such report. 

Section 9.6 Third Party Payments. 

(a) Existing Third Party Agreement. Except as otherwise provided in Section 14.3(b)(vii), [**] shall be [**] responsible for [**]
amounts payable under the Existing Third Party Agreement with respect to the Licensed Products. 
 (b) Additional Agreements. If
Celgene at any time or Agios before an Agios Opt-Out Notice believes that a license under Third Party Patent Rights or Third Party Know-How could be [**] to Develop, Manufacture or Commercialize the Licensed Products in the US Territory, then such
Party shall notify the (A) JDC if such notice is provided during Development or Manufacturing of Licensed Products for Development or (B) JCC if such notice is provided during Commercialization. 

(i) If the JDC or JCC, as applicable, agrees by unanimous vote to obtain such license, and if so, which of the Parties will do so, then the
Parties will proceed as determined by the JDC or JCC, as applicable. If the JDC or JCC, as applicable, cannot agree on whether to obtain such license or which Party will do so, then the matter will be escalated to the JSC for resolution in
accordance with Section 2.8; provided that, if the JSC cannot agree on which Party should obtain such license, then until an Agios Opt-Out Notice, Agios shall have the first right to obtain such license for the US Territory and if
Agios does not promptly exercise such right then Celgene shall have the right to do so, and after an Agios Opt-Out Notice, Celgene shall have the sole right to obtain such license. 

  
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 (ii) The costs of each such license to the extent the costs directly relate to the Licensed
Products shall be shared as Development Costs if paid prior to the First Commercial Sale of a Licensed Product in the US Territory and/or Commercialization Expenses if paid thereafter and, in the event of an Agios Opt-Out Date, shall be borne solely
by Celgene to the extent incurred after the Agios Opt-Out Date, subject to deduction from royalties in accordance with Section 9.5(c). 

(iii) For purposes of this Agreement, the Third Party Patent Rights and Third Party Know-How licensed pursuant to this Section 9.6 shall
be deemed “Collaboration Intellectual Property” of the Party obtaining such license. 
 (iv) (1) The Party designated to pursue
the license shall keep the other Party fully informed of the status of the negotiations with the Third Party and provide the other Party with copies of all draft agreements; (2) the other Party may provide comments and suggestions with respect
to the negotiation of the agreement with the Third Party, and the Party seeking the license shall reasonably consider all comments and suggestions reasonably recommended by the other Party; and (3) the Party seeking the license shall obtain a
license that is sublicensable to the other Party in accordance with the terms of this Agreement, treating (unless otherwise agreed by the Parties) the Third Party intellectual property as Collaboration Intellectual Property hereunder and treating
the agreement licensing such Third Party intellectual property in the same way as the Existing Third Party Agreement (including as provided in Section 8.5), except for payment obligations, which will be treated as provided in this
Section 9.6. 
 Section 9.7 Financial Records. The Parties shall keep, and shall require their respective Affiliates and
sublicensees to keep, complete and accurate books and records in accordance with the applicable Accounting Standards. The Parties shall keep, and shall require their respective Affiliates and sublicensees to keep, such books and records for at least
[**] years following the end of the Calendar Year to which they pertain. Such books of accounts shall be kept at the principal place of business of the financial personnel with responsibility for preparing and maintaining such records. With respect
to royalties, such records shall be in sufficient detail to support calculations of royalties due to Agios. Celgene and Agios shall also keep, and require their respective Affiliates and sublicensees to keep, complete and accurate records and books
of accounts containing all data reasonably required for the calculation and verification of Development Costs, including internal FTEs utilized by either Party, US Territory Profit or Loss and, if applicable, Annual Net Sales. 

  
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 Section 9.8 Audits. 

(a) Audit Team. Each Party may, upon request and at its expense (except as provided for herein), cause an internationally recognized
independent accounting firm selected by it (except one to whom the Auditee has a reasonable objection) (the “Audit Team”) to audit during ordinary business hours the books and records of the other Party and the correctness of any
payment made or required to be made to or by such Party, and any report underlying such payment (or lack thereof), pursuant to the terms of this Agreement. Prior to commencing its work pursuant to this Agreement, the Audit Team shall enter into an
appropriate confidentiality agreement with the Auditee obligating the Audit Team to be bound by obligations of confidentiality and restrictions on use of such Confidential Information that are no less restrictive than the obligations set forth in
Article XI. 
 (b) Limitations. In respect of each audit of the Auditee’s books and records: (i) the Auditee may be audited
only [**], (ii) no records for any given year for an Auditee may be audited more than [**]; provided that the Auditee’s records shall still be made available if such records impact another financial year which is being
audited, and (iii) the Audit Rights Holder shall only be entitled to audit books and records of an Auditee from the [**] Calendar Years prior to the Calendar Year in which the audit request is made. 

(c) Audit Notice. In order to initiate an audit for a particular Calendar Year, the Audit Rights Holder must provide written notice to
the Auditee. The Audit Rights Holder exercising its audit rights shall provide the Auditee with notice of [**] proposed dates of the audit not less than [**] days prior to the first proposed date. The Auditee will reasonably accommodate the
scheduling of such audit. The Auditee shall provide such Audit Team(s) with full and complete access to the applicable books and records and otherwise reasonably cooperate with such audit. 

(d) Audit Report. The audit report and basis for any determination by an Audit Team shall be made available first for review and
comment by the Auditee, and the Auditee shall have the right, at its expense, to request a further determination by such Audit Team as to matters which the Auditee disputes (to be completed no more than [**] days after the first determination is
provided to such Auditee and to be limited to the disputed matters). Such Audit Team shall not disclose to the Audit Rights Holder any information relating to the business of the Auditee except that which should properly have been contained in any
report required hereunder or otherwise required to be disclosed to the Audit Rights Holder to the extent necessary to verify the payments required to be made pursuant to the terms of this Agreement. 

(e) Payments. If the audit shows any under-reporting or underpayment, or overcharging by any Party, that under-reporting, underpayment
or overcharging shall be reported to the Audit Rights Holder and the underpaying or overcharging Party shall remit such underpayment or reimburse such overcompensation (together with interest at the rate set forth in Section 9.11) to the
underpaid or overcharged Party within [**] days after receiving the audit report. Further, if the audit for an annual period shows an under-reporting or underpayment or an overcharge by any Party for that period in excess of [**] percent ([**]%) of
the amounts properly determined, the underpaying or overcharging Party, as the case may be, shall 

  
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reimburse the applicable underpaid or overcharged Audit Rights Holder conducting the audit, for its respective audit fees and reasonable Out-of-Pocket Costs in connection with said audit, which
reimbursement shall be made within [**] days after receiving appropriate invoices and other support for such audit-related costs. 
 (f)
Definitions. For the purposes of the audit rights described herein, an individual Party subject to an audit in any given year will be referred to as the “Auditee” and the other Party who has certain and respective rights to
audit the books and records of the Auditee will be referred to as the “Audit Rights Holder.” 
 Section 9.9 Tax
Matters. 
 (a) Withholding Taxes. The milestones and other amounts payable by a Party to the other Party pursuant to this
Agreement (“Payments”) shall not be reduced on account of any taxes unless required by Law. The receiving Party alone shall be responsible for paying any and all taxes (other than withholding taxes required by Law to be deducted and
paid on the receiving Party’s behalf by the paying Party) levied on account of, or measured in whole or in part by reference to, any Payments it receives. The Parties will cooperate in good faith to obtain the benefit of any relevant tax
treaties to minimize as far as reasonably possible any taxes which may be levied on any Payments. The paying Party shall deduct or withhold from the Payments any taxes that it is required by Law to deduct or withhold. If the receiving Party is
entitled under any applicable tax treaty or any Law to a reduction of the rate of, or the elimination of, applicable withholding tax, it may deliver to the paying Party or the appropriate governmental authority (with the assistance of the paying
Party to the extent that this is reasonably required and is expressly requested in writing) the prescribed forms necessary to reduce the applicable rate of withholding or to relieve the paying Party of its obligation to withhold tax, and the paying
Party shall apply the reduced rate of withholding tax, or dispense with withholding tax, as the case may be; provided that the paying Party has received evidence of the receiving Party’s delivery of all applicable forms (and, if
necessary, its receipt of appropriate governmental authorization) at least [**] days prior to the time that the Payment is due. If, in accordance with the foregoing, the paying Party withholds any amount, it shall make timely payment to the proper
taxing authority of the withheld amount, and send to the receiving Party proof of such payment within [**] days following that latter payment. 

(b) Limited Gross-Up Obligation. Notwithstanding the foregoing, if the rights and obligations of a Party making payments hereunder are
assigned to an Affiliate or Third Party outside of the United States or Switzerland pursuant to Section 15.4, and if such Affiliate or Third Party shall be required by Law to withhold any additional taxes from or in respect of any sum payable
under this Agreement as a result of such assignment, then any such sum payable under this Agreement shall be increased to take into account the additional taxes withheld as may be necessary so that, after making all required withholdings, the
receiving Party receives an amount equal to the sum it would have received had no such assignment been made; provided, however, that, if the rights and obligations of the paying Party hereunder are assigned to an Affiliate or
Third Party outside of the United States or Switzerland pursuant to Section 15.4 and if at the time of such assignment such Affiliate or Third Party is not required by Law to withhold any additional taxes as a result of such assignment, the
paying Party shall not be required to increase any such sum payable under this Agreement in the event of a change 

  
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in Law. In addition, if the rights and obligations of the receiving Party hereunder are assigned to an Affiliate or Third Party pursuant to Section 15.4, the paying Party shall not have an
obligation to pay an additional sum pursuant to this Section 9.9(b) to the extent that the additional sum would not have been due pursuant to this Section 9.9(b) if the rights and obligations of the receiving Party hereunder had not been
assigned to an Affiliate or Third Party pursuant to Section 15.4. 
 Section 9.10 Currency Exchange. 

(a) Currency Conversion. Unless otherwise expressly stated in this Agreement, all amounts specified in, and all payments made under,
this Agreement shall be in United States Dollars. If any currency conversion shall be required in connection with the calculation of amounts payable under this Agreement, such conversion shall be made using the average of the buying and selling
exchange rate for conversion of the applicable foreign currency into United States Dollars, quoted for current transactions reported in The Wall Street Journal (U.S., Eastern Edition) (or similarly recognized source for currency exchange
rates agreed by the Parties) for the last [**] Business Days of the Calendar Quarter to which such payment pertains. 
 (b) Restrictions
on Payments. Where Payments are due in a country where, for reasons of currency, tax or other regulations, transfer of foreign currency out of such country is prohibited, the paying Party has the right to place Payments due to the other Party in
a bank account in such country in the name of and under the sole control of such other Party; provided, however, that the bank selected be reasonably acceptable to such other Party and that the paying Party inform such other
Party of the location, account number, amount and currency of money deposited therein. After such other Party has been so notified, those monies shall be considered as Payments duly paid to such Party and will be completely controlled by such Party.

 (c) Prohibitions on Payments. When in any country in the US Territory applicable Law prohibits both the transmittal and the
deposit of royalties on sales in such country, royalty payments due on Net Sales shall be suspended for as long as such prohibition is in effect and as soon as such prohibition ceases to be in effect, all royalties that Celgene would have been under
an obligation to transmit or deposit but for the prohibition shall forthwith be deposited or transmitted, to the extent allowable. 

Section 9.11 Late Payments. The paying Party shall pay interest to the receiving Party on the aggregate amount of any payments
that are not paid on or before the date such payments are due under this Agreement at a rate per annum equal to the lesser of the [**] month LIBOR plus [**] percent ([**]%), as reported by The Wall Street Journal, or the highest rate
permitted by applicable Law, calculated on the number of days such payments are paid after the date such payments are due; provided that, with respect to any disputed payments, no interest payment shall be due until such dispute is
resolved and the interest which shall be payable thereon shall be based on the finally-resolved amount of such payment, calculated from the original date on which the disputed payment was due through the date on which payment is actually made. 

Section 9.12 Payment by Affiliates. Notwithstanding anything in this Agreement to the contrary, all payments made by or on behalf
of a Party or its Affiliates to the other Party under this Agreement shall be paid to the other Party directly by such first Party or one of its Affiliates that is incorporated in the United States. 

  
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 Article X 

Intellectual Property Ownership, Protection and Related Matters 

Section 10.1 Ownership of Inventions. 

(a) Non-Collaboration Know-How. Any Know-How developed or generated by Celgene or Agios prior to or outside the Collaboration shall
remain the sole property of such Party. 
 (b) Sole Inventions. All Collaboration Know-How developed or generated solely by
employees, agents and consultants of a Party shall be owned exclusively by such Party. 
 (c) Joint Inventions. All Collaboration
Know-How developed or generated jointly by employees, agents and consultants of Celgene, on the one hand, and employees, agents and consultants of Agios, on the other hand (“Joint Inventions” and, any Patent Rights Covering such
Joint Inventions, “Joint Patents”) shall be owned jointly on the basis of each Party having an undivided interest without a duty to account to the other Party and shall be deemed to be Controlled by each Party. Each Party shall have
the right to use such Joint Inventions, or license such Joint Inventions to its Affiliates or any Third Party, or sell or otherwise transfer its interest in such Joint Inventions to its Affiliates or a Third Party, in each case without the consent
of the other Party (and, to the extent that applicable Law requires the consent of the other Party, this Section 10.1(c) shall constitute such consent), so long as such use, sale, license or transfer is subject to Section 8.6 and the
licenses granted pursuant to this Agreement and is otherwise consistent with this Agreement. 
 (d) Notice. Each Party agrees to
provide regular [**] written reports disclosing to the other Party all Collaboration Intellectual Property developed or generated by employees, agents and consultants of such Party and all Agios Intellectual Property and Celgene Intellectual
Property that becomes subject to this Agreement, which disclosures may be made in connection with the updates made in accordance with Section 3.1(d). 

(e) Inventorship. The determination of inventorship shall be made in accordance with United States patent laws. In the event of a
dispute regarding inventorship, if the Parties are unable to resolve the dispute, the Parties shall jointly engage [**] to resolve such dispute. The decision of such [**] shall be binding on the Parties with respect to the issue of inventorship.

 (f) Further Actions and Assignments. Each Party shall take all further actions and execute all assignments requested by the other
Party and reasonably necessary or desirable to vest in the other Party the ownership rights set forth in this Article X. 

  
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 Section 10.2 Prosecution of Patent Rights. Subject to the terms and conditions of the
Existing Third Party Agreement to the extent such agreement applies to the Agios Patent Rights or Agios Collaboration Patent Rights in the US Territory, the following provisions shall apply with respect to the Agios Patent Rights, Celgene Patent
Rights and Collaboration Patent Rights in the US Territory: 
 (a) Agios Patent Rights. Subject to the provisions of
Section 10.2(h) and coordination with the JPC, Agios shall have the initial right and option to Prosecute the Agios Patent Rights and Agios Collaboration Patent Rights (excluding Joint Patents) in the US Territory with respect to which Celgene
does not have the initial right to Prosecute pursuant to Section 10.2(b). In the event that Agios declines to Prosecute such Patent Rights, it shall give Celgene reasonable notice to this effect, sufficiently in advance to permit Celgene to
undertake such Prosecution in such country without a loss of rights, and thereafter Celgene may, upon written notice to Agios, Prosecute such Patent Rights in Agios’ name subject to coordination with the JPC. 

(b) Agios Patent Rights Prosecuted by Celgene. Subject to coordination with the JPC, Celgene shall have the initial right and option to
Prosecute the Core Patent Rights within any of the Agios Patent Rights or Agios Collaboration Patent Rights in the US Territory that specifically Cover a Compound or a Licensed Product (“Celgene Controlled Agios Patent Rights”).
Certain of the Agios Patent Rights and Agios Collaboration Patent Rights may from time to time Cover some Celgene Controlled Agios Patent Rights and other Agios Patent Rights or Agios Collaboration Patent Rights in the same application. Each Party
will cooperate reasonably with any requests of the other Party from time to time to attempt to isolate Celgene Controlled Agios Patent Rights, on the one hand, from applications containing other Agios Patent Rights and Agios Collaboration Patent
Rights, on the other hand. In the event that Celgene declines to Prosecute such Patent Rights, Celgene shall give Agios reasonable notice to this effect, sufficiently in advance to permit Agios to undertake such Prosecution in such country without a
loss of rights, and thereafter Agios may, upon written notice to Celgene, Prosecute such Patent Rights in Agios’ name subject to coordination with the JPC. 

(c) Celgene Patent Rights. Celgene shall have the sole right and option to Prosecute the Celgene Patent Rights in the US Territory and,
subject to coordination with the JPC, the initial right and option to Prosecute the Celgene Collaboration Patent Rights (excluding Joint Patents) in the US Territory. In the event Celgene declines to Prosecute any such Celgene Collaboration Patent
Right, Celgene shall give Agios reasonable notice to this effect, sufficiently in advance to permit Agios to undertake such Prosecution for such Celgene Collaboration Patent Right in such country without a loss of rights, and thereafter Agios may,
upon written notice to Celgene, Prosecute such Patent Rights in Celgene’s name. 
 (d) Joint Patents. The JPC shall determine
which Party shall have the initial right and option to Prosecute Joint Patents in the US Territory; provided that (i) if the JPC cannot make such determination by unanimous vote, then (x) Celgene shall have such initial right
and option with respect to such Joint Patents that (A) are Core Patent Rights and that specifically Cover a Compound or Licensed Product or (B) claim or embody an improvement to technology claimed or embodied in Celgene Intellectual
Property, and (y) Agios shall have such initial right and option with respect to all other such Joint Patents; and (ii) in the event that the Party with the initial right to Prosecute Joint Patents declines the option to Prosecute any such
Joint Patents in any country, such Party shall give the other Party reasonable notice to this effect, sufficiently in advance to permit such other Party to undertake such Prosecution in such 

  
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country without a loss of rights, and thereafter such other Party may, upon written notice to the first Party, Prosecute such Joint Patent in both Parties’ names, with expenses shared as
provided in Section 10.2(e). 
 (e) Costs and Expenses. The Parties shall jointly bear all costs and expenses in Prosecuting
Agios Patent Rights, Agios Collaboration Patent Rights, Celgene Collaboration Patent Rights and Joint Patents (collectively, “Patent Prosecution Expenses”) in the US Territory as either Development Costs (to the extent incurred for
any country of the US Territory prior to the First Commercial Sale of the Licensed Product in the country to which the Patent Rights relate) or Commercialization Expenses (if incurred after First Commercial Sale of the Licensed Product in the US
Territory); provided, however, that, in the event of an Agios Opt-Out Date, all such Patent Prosecution Expenses incurred by Celgene following the Agios Opt-Out Date shall be borne solely by Celgene. 

(f) Strategy; Failure of JPC to Agree; Diligence and Cooperation. 

(i) The JPC shall attempt to agree upon a strategy (which may be updated from time to time) for Prosecution of Agios Patent Rights,
Collaboration Patent Rights and Joint Patents in the US Territory, including the scope and priority of the claims to be pursued within such Patent Rights and to maximize the value of such Patent Rights, together with their foreign counterparts in
the ROW Territory, on a global basis. Any failure by the JPC to agree by unanimous vote with respect to such strategy or any other Prosecution matter will be attempted to be resolved as specified in Section 2.8(e), and if such attempt fails,
then as follows: Prosecution matters involving (A) Agios Patent Rights (other than Celgene Controlled Agios Patent Rights therein) may be resolved by Agios; (B) Agios Collaboration Patent Rights (other than Celgene Controlled Agios Patent
Rights and Joint Patents therein) may be resolved by Agios; (C) Celgene Controlled Agios Patent Rights and Celgene Collaboration Patent Rights (other than Joint Patents) may be resolved by Celgene; (D) all Core Patent Rights within the
Joint Patents may be resolved by Celgene; and (E) all other Joint Patents may be resolved only by Mutual Consent. The Party conducting Prosecution (the “Prosecuting Party”) with respect to each such Patent Right shall follow
such strategy in connection with all Prosecution of such Patent Rights unless the JPC approves of a divergence from such strategy (with any failure by the JPC to agree by unanimous vote to be resolved in accordance with Section 2.8(e) and the
foregoing sentence). 
 (ii) The Prosecuting Party shall be entitled to use patent counsel selected by it and reasonably acceptable to the
non-Prosecuting Party (including in-house patent counsel as well as outside patent counsel) for the Prosecution of the Patents Rights subject to Section 10.2(a), (b), (c), and (d). Each Party agrees to cooperate with the other with respect to
the Prosecution of such Patent Rights pursuant to this Section 10.2, including (x) executing all such documents and instruments and performing such acts as may be reasonably necessary in order to permit the other Party to undertake any
Prosecution of Patent Rights that such other Party is entitled, and has elected, to Prosecute, as provided for in Sections 10.2(a), 10.2(b), 10.2(c), and 10.2(d) and (y) giving consideration to the proper scope of Patent Rights. The Prosecuting
Party shall: 
 (A) regularly provide the JPC in advance with reasonable information relating to the Prosecuting Party’s Prosecution
of Patent Rights hereunder, including by providing copies of substantive communications, notices and actions submitted to or received from the relevant patent authorities and copies of drafts of filings and correspondence that the Prosecuting Party
proposes to submit to such patent authorities, each of which shall be provided at least [**] days prior to any filing or response deadlines, or within [**] Business Days of the Prosecuting Party’s receipt of any official correspondence if such
correspondence only allows for [**] days or less to respond; provided that, if the foregoing time periods are not practicable under the circumstances, the Prosecuting Party shall provide such copies as far in advance as is practicable
but with sufficient time for the non-Prosecuting party to provide meaningful input; 

  
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 (B) consider in good faith and consult with the non-Prosecuting Party regarding its timely
comments with respect to the same; 
 (C) use Commercially Reasonable Efforts to Prosecute additional claims substantially similar to those
suggested by the non-Prosecuting Party, if any, in such jurisdictions of the Territory reasonably requested by the non-Prosecuting Party; and 

(D) consult with the JPC and non-Prosecuting Party before taking any action that would have a material adverse impact on the scope of claims
within the Agios Patent Rights or Collaboration Patent Rights (including the Joint Patents), as applicable. 
 (iii) The JPC shall
determine the countries in which Agios Patent Rights and Collaboration Patent Rights (including Joint Patents) shall be Prosecuted, with the understanding that the countries set forth on Exhibit F of this Agreement shall generally form the
basis for the overall Prosecution strategy for such Patent Rights and that any failure of the JPC to determine such countries by unanimous vote will be resolved as provided in clause (i) of this Section 10.2(f). Further, Agios shall
consult with the JPC well in advance of [**] and [**] deadlines as to additional countries (if any) in which the JPC or Celgene desires that the Agios Patent Rights and Collaboration Patent Rights be Prosecuted. 

(iv) The Prosecuting Party agrees not to abandon the subject matter of a claim in an Agios Patent Right, Collaboration Patent Right or Joint
Patent or narrow such claim except in response to an office action from the applicable patent office that, in the Prosecuting Party’s reasonable judgment after consultation with the non-Prosecuting Party, requires such abandonment or narrowing;
provided that, prior to such abandonment or narrowing, if feasible, the Parties will co-operate to file divisional or continuation applications to separate such claim. 

(g) Third Party Rights. Agios covenants and agrees that it shall not grant any Third Party any right to control the Prosecution of the
Agios Patent Rights or Agios Collaboration Patent Rights or to approve or consult with respect to any Patent Rights licensed to Celgene hereunder, in any case, that is more favorable to the Third Party than the rights granted to Celgene hereunder or
that otherwise conflicts with Celgene’s rights hereunder. 
 (h) Existing Third Party Agreement. Each Party acknowledges that,
pursuant to the Existing Third Party Agreement, the applicable licensors thereunder Prosecute the Agios Patent Rights covered by such agreements; provided that Agios may have certain rights to


  
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assume Prosecution under such agreement. Agios agrees to keep Celgene fully informed of these rights, as well as provide to Celgene all information and copies of documents received from the
licensors under the Existing Third Party Agreement or their patent counsel relating to the Agios Patent Rights covered by such agreements. To the extent that Agios is permitted to proceed with Prosecution or provide comments or suggestions to patent
documents under the Existing Third Party Agreement, then the Agios Patent Rights under such Existing Third Party Agreement shall be treated in the same manner as other Agios Patent Rights under this Section 10.2, and Agios shall exercise all
such rights with respect to such Agios Patents Rights pursuant to the instructions of Celgene, if Celgene is given the right to act under this Section 10.2. 

Section 10.3 Third Party Infringement of Agios Patent Rights and Collaboration Patent Rights. Subject to the terms and conditions
of the Existing Third Party Agreement to the extent such agreement applies to the Agios Patent Rights or Agios Collaboration Patent Rights in the US Territory, the following provisions shall apply with respect to the Agios Patent Rights, Agios
Collaboration Patent Rights, Celgene Collaboration Patent Rights, Agios Know-How, Agios Collaboration Know-How, and Celgene Collaboration Know-How in the US Territory: 

(a) Notice. Each Party shall immediately provide the other Party with written notice reasonably detailing any (i) known or alleged
infringement of any Agios Patent Rights or Collaboration Patent Rights, or known or alleged misappropriation of any Agios Know-How or Collaboration Know-How, by a Third Party, (ii) “patent certification” filed in the United States
under 21 U.S.C. §355(b)(2) or 21 U.S.C. §355(j)(2) or similar provisions in other jurisdictions, and (iii) any declaratory judgment, opposition, or similar action alleging the invalidity, unenforceability or non-infringement of any
such intellectual property rights (collectively “Third Party Infringement”). 
 (b) First Right to Initiate Infringement
Actions. Until an Agios Opt-Out Notice, Agios shall have the initial right throughout the US Territory, but not the obligation, to initiate a suit or take other appropriate action in the US Territory that Agios believes is reasonably required to
protect the Agios Intellectual Property or Agios Collaboration Intellectual Property against the infringement, including Third Party Infringement, unauthorized use or misappropriation by a Third Party that relates to a Licensed Product
(“Competitive Infringement”). Celgene shall have the sole right throughout the US Territory, but not the obligation, to initiate a suit or take other appropriate action in the US Territory that Celgene believes is reasonably
required to protect the Celgene Collaboration Patent Rights from Competitive Infringement. Upon and after an Agios Opt-Out Notice, Celgene also shall have the initial right throughout the US Territory, but not the obligation, to initiate a suit or
take other appropriate action in the US Territory that Celgene believes is reasonably required to protect the Agios Patent Rights and Agios Collaboration Patent Rights from Competitive Infringement. The Party having such initial or sole right under
the preceding three sentences (“Initial Enforcement Party”) shall give the other Party advance notice of the Initial Enforcement Party’s intent to file any such suit or take any such action and the reasons therefor, and shall
provide the other Party with an opportunity to make suggestions and comments regarding such suit or action. Thereafter, the Initial Enforcement Party shall keep the other Party promptly informed, and shall from time to time consult with the other
Party regarding the status of any such suit or action and shall provide the other Party with copies of all material documents (e.g., complaints, answers, counterclaims, material motions, orders of the court, memoranda of law and legal


  
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briefs, interrogatory responses, depositions, material pre-trial filings, expert reports, affidavits filed in court, transcripts of hearings and trial testimony, trial exhibits and notices of
appeal) filed in, or otherwise relating to, such suit or action. Without limiting the generality of the foregoing, the Parties shall discuss in good faith the Initial Enforcement Party’s intended response to a Competitive Infringement. 

(c) Preparation to Enforce. After the First Commercial Sale of a Licensed Product in the US Territory, subject to coordination with the
JPC, the Initial Enforcement Party shall use reasonable efforts to prepare for the possibility of suit for Competitive Infringement starting [**] years after such First Commercial Sale. Such preparation includes identifying and retaining experts,
selecting and retaining outside counsel, having outside counsel conduct a pre-litigation diligence investigation into potential validity and unenforceability arguments, data and document collection and review, and other actions reasonably capable of
being conducted before initiation of any such litigation. 
 (d) Step-in Rights. If Agios, as the Initial Enforcement Party, fails to
initiate a suit or take such other appropriate action under Section 10.3(b) above within [**] days after becoming aware of the Competitive Infringement, then Celgene may, in its discretion, provide Agios with written notice of Celgene’s
intent to initiate a suit or take other appropriate action to combat such Competitive Infringement. If Celgene, as the Initial Enforcement Party for the Agios Patent Rights and Agios Collaboration Patent Rights after the Agios Opt-Out Notice, fails
to initiate a suit or take such other appropriate action under Section 10.3(b) above within [**] days after becoming aware of the Competitive Infringement, then Agios may, in its discretion, provide Celgene with written notice of Agios’
intent to initiate a suit or take other appropriate action to combat such Competitive Infringement. If the Party with such step-in rights under either of the two preceding sentences (“Step-In Enforcement Party”) provides such notice
and the Initial Enforcement Party fails to initiate a suit or take such other appropriate action within [**] days after receipt of such notice from the Step-In Enforcement Party, then Step-In Enforcement Party shall have the right, but not the
obligation, to initiate a suit or take other appropriate action that it believes is reasonably required to protect the applicable Agios Intellectual Property or Agios Collaboration Intellectual Property from Competitive Infringement. The Step-In
Enforcement Party shall give the Initial Enforcement Party advance notice of the Step-In Enforcement Party’s intent to file any such suit or take any such action and the reasons therefor and shall provide the Initial Enforcement Party with an
opportunity to make suggestions and comments regarding such suit or action. Thereafter, the Step-In Enforcement Party shall keep the Initial Enforcement Party promptly informed and shall from time to time consult with the Initial Enforcement Party
regarding the status of any such suit or action and shall provide the Initial Enforcement Party with copies of all material documents (e.g., complaints, answers, counterclaims, material motions, orders of the court, memoranda of law and legal
briefs, interrogatory responses, depositions, material pre-trial filings, expert reports, affidavits filed in court, transcripts of hearings and trial testimony, trial exhibits and notices of appeal) filed in, or otherwise relating to, such suit or
action. For the avoidance of any doubt, this Section 10.3(d) shall not be applicable to any of the Celgene Collaboration Patent Rights, so Agios shall not have any right to be the Step-In Enforcement Party for Celgene Collaboration Patent
Rights without the written agreement of Celgene. 

  
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 (e) Conduct of Action; Costs. The Party initiating suit shall have the sole and exclusive
right to select counsel for any suit initiated by it under this Section 10.3, which counsel must be reasonably acceptable to the other Party. If required under applicable Law in order for such Party to initiate and/or maintain such suit, the
other Party shall join as a party to the suit. If requested by the Party initiating suit, the other Party shall provide reasonable assistance to the Party initiating suit in connection therewith at no charge to such Party except that the initiating
Party shall reimburse the other Party for Out-of-Pocket Costs, other than outside counsel expenses, incurred in rendering such assistance. The Party initiating suit shall assume and pay all of its own Out-of-Pocket Costs incurred in connection with
any litigation or proceedings described in this Section 10.3, including the fees and expenses of the counsel selected by it, provided that, prior to the Agios Opt-Out Date, if any, such fees and expenses shall be included in the
calculation of Development Costs (if incurred in any country of the Territory prior to the First Commercial Sale of a Licensed Product in the country) or Commercialization Expenses (if incurred after the First Commercial Sale of a Licensed Product
in the US Territory). The other Party shall have the right to participate and be represented in any such suit by its own counsel at its own expense (and which shall not be a Patent and Trademark Enforcement Cost or other cost that is a factor in the
calculation of US Territory Profit or Loss). For clarity, if required under applicable Law in order for AIS or CIS II to initiate and/or maintain a suit pursuant to which it has the right to initiate and/or maintain under Section 10.3 of the
AGI-23088 ROW Agreement, each Party, as applicable, shall join as a party to such suit. 
 (f) Recoveries. Any recovery obtained as a
result of any proceeding described in this Section 10.3 or from any counterclaim or similar claim asserted in a proceeding described in Section 10.4, by settlement or otherwise, shall be applied in the following order of priority: 

(i) first, the Party initiating the suit or action shall be reimbursed for all previously unreimbursed (or not otherwise included in the
calculation of Development Costs or Commercialization Expenses) Out-of-Pocket Costs in connection with such proceeding; and 
 (ii) second,
any remainder shall be (A) treated as Additional Revenue, if obtained before the Agios Opt-Out Date, if any; or (B) paid [**] percent ([**]%) to the Party initiating the suit or action, and [**] percent ([**]%) to the other Party, if
obtained on or after the Agios Opt-Out Date, if any. 
 (g) Existing Third Party Agreement. In the event that (i) a Patent Right
covered by the Existing Third Party Agreement is at issue in an action under this Section 10.3 or Section 10.4, (ii) Agios has a right to enforce the Agios Patent Rights under such Existing Third Party Agreement, and
(iii) Celgene desires to enforce such Patent in accordance with the procedures under this Section 10.3 or Section 10.4, as applicable, then Agios shall either obtain the licensors’ consent under the Existing Third Party Agreement
so that Celgene may file such an action in its own name or shall undertake such an action on Celgene’s behalf. 

  
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 Section 10.4 Claimed Infringement; Claimed Invalidity. 

(a) Infringement of Third Party Rights. Each Party shall promptly notify the other Party in writing of any allegation by a Third Party
that the activity of either Party or their Affiliates or Licensee Partners under this Agreement infringes or may infringe the intellectual property rights of such Third Party. If a Third Party asserts or files against a Party or its Affiliates, in
the US Territory, any claim of infringement of the intellectual property rights of such Third Party or other action relating to alleged infringement of such intellectual property rights (“Third Party Infringement Action”), then,
unless otherwise agreed by the Parties: 
 (i) In the event of a Third Party Infringement Action against a single Party, the unnamed Party
shall have the right, in the unnamed Party’s sole discretion, to participate in the defense of such legal action with legal counsel selected by the unnamed Party and reasonably acceptable to the named Party (the costs of which shall not be a
Patent and Trademark Enforcement Cost or other cost that is a factor in the calculation of US Territory Profit or Loss). The Party named in such Third Party Infringement Action shall have the right to control the defense of the action, but shall
notify and keep the unnamed Party apprised in writing of such action and shall consider and take into account the unnamed Party’s reasonable interests and requests and suggestions regarding the defense of such action. In the event of a Third
Party Infringement Action against both Parties, the Parties shall attempt to mutually agree as to which Party shall control the defense of such Third Party Infringement Action; provided that, in the event of an Agios Opt-Out Notice or
the failure of the Parties to so mutually agree, Celgene shall have the right to control the defense of such Third Party Infringement Action. 

(ii) The non-controlling Party of a Third Party Infringement Action shall reasonably cooperate with the controlling Party in the preparation
and formulation of a defense to such Third Party Infringement Action, and in taking other steps reasonably necessary to respond to such Third Party Infringement Action. The controlling Party shall have the right to select its counsel for the defense
to such Third Party Infringement Action, which counsel must be reasonably acceptable to the non-controlling Party if both Parties have been named as defendants in the action. The non-controlling Party shall also have the right to participate and be
represented in any such suit by its own counsel at its own expense (and which shall not be a Patent and Trademark Enforcement Cost or other cost that is a factor in the calculation of US Territory Profit or Loss). The controlling Party shall not
(and shall cause its Affiliates and Licensee Partners not to) either (A) admit infringement, validity or enforceability of the asserted intellectual property rights, (B) pay any amount of money in settlement thereof, unless the controlling
Party does not claim the payment as a Patent and Trademark Enforcement Cost or other cost that is a factor in the calculation of US Territory Profit or Loss, or (C) enter into a license for the asserted intellectual property rights upon terms
that would restrict either Party from fully exploiting such rights consistently with the scope of the rights and obligations of both Parties under this Agreement and the AGI-23088 ROW Agreement, in each case (A) - (C), without the written consent of
the non-controlling Party, which will not to be unreasonably withheld, conditioned or delayed. For the avoidance of doubt, except as provided in the foregoing clause (B), the costs of such defense and settlement (if approved by the non-controlling
Party) shall be deemed Patent and Trademark Enforcement Costs that are factored into the calculation of US Territory Profit or Loss. 

  
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 (iii) If the Party entitled to control the defense under Section 10.4(a)(i) or
(ii) fails to proceed in a timely manner with respect to such defense, the other Party shall have the right to control the defense of such claim upon the same conditions set forth therein. 

(iv) If requested by the Party controlling the defense, the Parties shall enter into a joint defense agreement that further outlines their
rights and responsibilities consistent with the terms of this Section or as otherwise mutually agreed.] 
 (b) Patent Invalidity
Claim. If a Third Party at any time asserts a claim that any issued Agios Patent Right or Agios Collaboration Patent Right (including Joint Patents) is invalid or otherwise unenforceable (an “Invalidity Claim”), whether as a
defense in an infringement action brought by Agios or Celgene pursuant to Section 10.3(b) or (d), in a declaratory judgment action or in a Third Party Infringement claim brought against Agios or Celgene, the Parties shall cooperate with each other
in preparing and formulating a response to such Invalidity Claim; provided that, subject to the terms and conditions of the Existing Third Party Agreement to the extent such agreement applies to such Agios Patent Right or Agios
Collaboration Patent Right, the Party who has (or would have) control over litigation pursuant to Section 10.3(b) or (d) shall have the sole right to control the defense and settlement of any such Invalidity Claim as if it were litigation
initiated therein. For the avoidance of doubt, any claim asserted against any Agios Patent Right or Agios Collaboration Patent Right before any such right is issued is deemed a Prosecution matter that is the subject of Section 10.2. 

Section 10.5 Patent Term Extensions. The JPC shall, as necessary and appropriate, use reasonable efforts to agree upon a joint
strategy for obtaining, and cooperate with each other in obtaining, patent term extensions for Agios Patent Rights, Agios Collaboration Patent Rights and Celgene Collaboration Patent Rights that Cover Licensed Products. If the JPC is unable to agree
upon which of such Patent Rights should be extended, and the matter remains unresolved after the procedure described in Section 2.8(e), then the Initial Enforcement Party shall have the right to resolve the dispute, subject in each case to the
terms and conditions of the Existing Third Party Agreement to the extent such agreement applies to such Agios Patent Right or Agios Collaboration Patent Right. 

Section 10.6 Patent Marking. Each Party shall comply with the patent marking statutes in each country in which the Licensed
Product is Manufactured or Commercialized by or on behalf of a Party or their respective Affiliates or sublicensees, as applicable, hereunder. 

Section 10.7 CREATE Act Application. It is agreed and acknowledged that this Agreement establishes a qualifying collaboration
within the scope of the U.S. CREATE Act and, accordingly, shall be deemed to constitute a “Joint Research Agreement” for all purposes under the CREATE Act. Neither Party shall invoke the provisions of the CREATE Act, or file this
Agreement, in connection with the prosecution of any patent application claiming, in whole or in part, any CREATE Act invention without the prior written consent of the other Party. In the event that a Party, during the course of prosecuting a
patent application claiming a CREATE Act invention (a “CREATE Act Patent”), deems it necessary to file a terminal disclaimer to overcome an obviousness type double patenting rejection in view of an earlier filed patent held by the
other Party (the “Earlier Patent”), then, if the Parties agree, the Parties shall coordinate the filing of such terminal disclaimer in good faith, and, to the extent required under the CREATE


  
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Act, both Parties shall agree, in such terminal disclaimer, that they shall not separately enforce the CREATE Act Patent independently from the Earlier Patent. To this end, to the extent required
under the CREATE Act, following the filing of such terminal disclaimer, the Parties shall, in good faith, coordinate all enforcement actions with respect to the CREATE Act Patent. 

Section 10.8 Challenges to Patent Rights. 

(a) Certain Consequences of Celgene Challenges. Without limiting Celgene’s obligations pursuant to Section 8.5(b), if Celgene
or any of its Affiliates or any of its sublicensees under the licenses granted to Celgene in this Agreement (i) initiates or requests an interference or opposition proceeding with respect to any Agios Patent Right or Agios Collaboration Patent
Right that Covers a Target or Licensed Product, (ii) makes, files or maintains any claim, demand, lawsuit, or cause of action to challenge the validity or enforceability of any Agios Patent Right or Agios Collaboration Patent Right that Covers
a Target or Licensed Product, or (iii) funds or otherwise provides material assistance to any other Person with respect to any of the foregoing (any of the actions described in the foregoing clauses (i), (ii) and (iii), a
“Challenge”), and if the outcome of such Challenge is that any claim of an Agios Patent Right or Agios Collaboration Patent Right that Covers a Target or Licensed Product and that is subject to such Challenge remains valid and
enforceable, then (A) Celgene shall [**] Agios in connection with such Challenge (which amounts shall not be deemed to constitute Development Costs or Commercialization Expenses), and (B) thereafter, if the Agios Opt-Out Date has not
occurred before such outcome, then Agios’ share of US Territory Profit or Loss hereunder with respect to any Licensed Product Covered by any remaining such valid and enforceable claim of a Challenged Agios Patent Right or Agios Collaboration
Patent Right shall [**], notwithstanding Section 9.4(a), and if the Agios Opt-Out Date has occurred before such outcome, then all royalty amounts payable by Celgene to Agios hereunder with respect to any Licensed Product Covered by any
remaining such valid and enforceable claim of a Challenged Agios Patent Right or Agios Collaboration Patent Right shall [**] of the otherwise applicable royalty amounts payable under Section 9.5(a). 

(b) No Use of Confidential Information. Without limiting Celgene’s obligations pursuant to Section 10.8(a), Celgene shall
not, and shall ensure that its Affiliates and its sublicensees under the licenses granted to Celgene in this Agreement do not, use or disclose any Confidential Information of Agios or any nonpublic information regarding the Prosecution or
enforcement of any Agios Patent Rights or Agios Collaboration Patent Rights to which Celgene or any of its Affiliates or sublicensees are or become privy as a consequence of the rights granted to Celgene pursuant to this Article X, in initiating,
requesting, making, filing or maintaining, or in funding or otherwise assisting any other Person with respect to, any Challenge. 
 (c)
Certain Consequences of Agios Challenges. The provisions of Sections 10.8(a) and 10.8(b) shall apply with respect to Celgene Patent Rights and Celgene Collaboration Patent Rights licensed to Agios pursuant to Section 8.1, in each case,
substituting “Celgene” for “Agios” and vice versa with respect to all obligations and definitions, and otherwise mutatis mutandis. 

  
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 Section 10.9 Celgene Intellectual Property. Celgene shall have the sole right, but
not the obligation, to initiate a suit or take other appropriate action that it believes is reasonably required to protect the Celgene Intellectual Property without any obligation to consult with Agios. Notwithstanding anything to the contrary in
Section 10.3 or 10.4, all recoveries with respect to any such action, by settlement or otherwise, shall be [**] by Celgene. 

Article XI 

Confidentiality 

Section 11.1 Confidential Information. All Confidential Information of a Party (“Disclosing Party”) shall not be
used by the other Party (the “Receiving Party”) except in performing its obligations or exercising rights explicitly granted under this Agreement and shall be maintained in confidence by the Receiving Party and shall not otherwise
be disclosed by the Receiving Party to any Third Party, without the prior written consent of the Disclosing Party with respect to such Confidential Information, except to the extent that the Confidential Information: 

(a) was known by the Receiving Party or its Affiliates prior to its date of disclosure to the Receiving Party; or 

(b) is lawfully disclosed to the Receiving Party or its Affiliates by sources other than the Disclosing Party rightfully in possession of the
Confidential Information; or 
 (c) becomes published or generally known to the public through no fault or omission on the part of the
Receiving Party, its Affiliates or its sublicensees; or 
 (d) is independently developed by or for the Receiving Party or its Affiliates
without reference to or reliance upon such Confidential Information, as established by written records. 
 Section 11.2 Permitted
Disclosure. The Receiving Party may provide the Disclosing Party’s Confidential Information: 
 (a) to the Receiving Party’s
respective employees, consultants and advisors, and to the employees, consultants and advisors of such Party’s Affiliates, who have a need to know such information and materials for performing obligations or exercising rights expressly granted
under this Agreement and have an obligation to treat such information and materials as confidential; 
 (b) to patent offices in order to
seek or obtain Patent Rights or to Regulatory Authorities in order to seek or obtain approval to conduct Clinical Trials or to gain Regulatory Approval with respect to the Licensed Products as contemplated by this Agreement; provided
that such disclosure may be made only following reasonable notice to the Disclosing Party and to the extent reasonably necessary to seek or obtain such Patent Rights or Regulatory Approvals; or 

(c) if such disclosure is required by judicial order or applicable Law or to defend or prosecute litigation or arbitration; provided
that, prior to such disclosure, to the extent 

  
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permitted by Law, the Receiving Party promptly notifies the Disclosing Party of such requirement, cooperates with the Disclosing Party to take whatever action it may deem appropriate to protect
the confidentiality of the information and furnishes only that portion of the Disclosing Party’s Confidential Information that the Receiving Party is legally required to furnish. 

Section 11.3 Publicity; Terms of this Agreement; Non-Use of Names. 

(a) Public Announcements. Except as required by judicial order or applicable Law (in which case, Section 11.3(b) must be complied
with) or as explicitly permitted by this Article XI, neither Party shall make any public announcement concerning this Agreement without the prior written consent of the other Party, which consent shall not be unreasonably withheld or delayed. The
Party preparing any such public announcement shall provide the other Party with a draft thereof at least [**] Business Days prior to the date on which such Party would like to make the public announcement (or, in extraordinary circumstances, such
shorter period as required to comply with applicable Law). Notwithstanding the foregoing, the Parties shall issue a press release, in the form attached as Exhibit G to this Agreement within [**] after the Effective Date. Neither Party shall
use the name, trademark, trade name or logo of the other Party or its employees in any publicity or news release relating to this Agreement or its subject matter, without the prior express written permission of the other Party. For purposes of
clarity, either Party may issue a press release or public announcement or make such other disclosure relating to this Agreement if the contents of such press release, public announcement or disclosure (x) (i) does not consist of financial
information and has previously been made public other than through a breach of this Agreement by the issuing Party or its Affiliates, (ii) is contained in such Party’s financial statements prepared in accordance with Accounting Standards,
or (iii) is contained in the Redacted Version of this Agreement, and (y) is material to the event or purpose for which the new press release or public announcement is made. 

(b) Permitted Disclosures. Notwithstanding the terms of this Article XI: 

(i) Either Party shall be permitted to disclose the existence and terms of this Agreement to the extent required, in the reasonable opinion
of such Party’s legal counsel, to comply with applicable Laws, including the rules and regulations promulgated by the Securities and Exchange Commission or any other governmental authority. Notwithstanding the foregoing, before disclosing this
Agreement or any of the terms hereof pursuant to this Section 11.3(b), the Parties will coordinate in advance with each other in connection with the redaction of certain provisions of this Agreement with respect to any filings with the
Securities and Exchange Commission, London Stock Exchange, the UK Listing Authority, NYSE, the NASDAQ Stock Market or any other stock exchange on which securities issued by a Party or a Party’s Affiliate are traded (the “Redacted
Version”), and each Party will use commercially reasonable efforts to seek confidential treatment for such terms as may be reasonably requested by the other Party; provided that the Parties will use commercially reasonable
efforts to file redacted versions with any governing bodies which are consistent with the Redacted Version. 

  
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 (ii) Either Party may disclose the existence and terms of this Agreement in confidence: 

(A) to (1) its attorneys, professional accountants, and auditors, and (2) bankers or other financial advisors in connection with a public
offering, other strategic transaction, or corporate valuation for internal purposes; provided that any such disclosure to such professional accountants, auditors, bankers or other financial advisors is under an agreement to keep the
terms of confidentiality and non-use no less rigorous than the terms contained in this Agreement and to use such information solely for the applicable purpose permitted pursuant to this Section 11.3(b)(ii)(A); 

(B) to the licensors under the Existing Third Party Agreement; provided that such disclosure is under the confidentiality and
non-use provisions of such agreement; 
 (C) to potential acquirers (and their respective attorneys and professional advisors), in
connection with a potential merger, acquisition or reorganization; provided that (1) the Party making the disclosure has a bona fide offer from such Third Party for such a transaction, and (2) such disclosure is under an
agreement to keep the terms of confidentiality and non-use no less rigorous than the terms contained in this Agreement and to use such information solely for the purpose permitted pursuant to this Section 11.3(b)(ii)(C); 

(D) to existing investors, lenders or permitted assignees of such Party (and their respective attorneys and professional advisors);
provided that such disclosure is under an agreement to keep the terms of confidentiality and non-use no less rigorous than the terms contained in this Agreement; and 

(E) to potential investors, lenders or permitted assignees of such Party, or to potential licensees or sublicensees of such Party (and their
respective attorneys and professional advisors); provided that (1) such disclosure shall not be made prior to [**] Business Days prior to the good faith anticipated closing date for the investment, loan, assignment or license, as
applicable, and shall be made only if such Party reasonably concludes that such transaction with such disclosee is likely to be consummated; (2) the disclosure shall be limited to the Redacted Version plus such additional terms and conditions
reasonably requested by the disclosing Party and consented to by the other Party (for purposes of clarity, the disclosing Party shall not be obligated to disclose the identity of the disclosee in order to request such consent); and (3) such
disclosure is under an agreement to keep the terms of confidentiality and non-use no less rigorous than the terms contained in this Agreement. 

(iii) The Parties acknowledge the importance of supporting each other’s efforts to publicly disclose results and significant
developments regarding the Licensed Products and other activities in connection with this Agreement that may include information that is not otherwise permitted to be disclosed under this ARTICLE XI, and that may be beyond what is required by
applicable Law, and each Party may make such disclosures from time to time. Such disclosures may include achievement of milestones, significant events in the development and regulatory process, commercialization activities and the like. Except for
the initial press release described in Section 11.3(a), whenever a Party (the “Requesting Party”) elects to make any such public disclosure, it shall first notify the other Party (the “Cooperating Party”) of
such planned press release or public announcement and provide a draft for review at least [**] Business Days in advance of issuing such press release or making such public announcement (or, with respect to


  
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press releases and public announcements that are required by applicable Law, or by regulation or rule of any public stock exchange (including NASDAQ), with as much advance notice as possible
under the circumstances if it is not possible to provide notice at least [**] Business Days in advance); provided, however, that a Party may issue such press release or public announcement without such prior review by the other
Party if (A) the contents of such press release or public announcement have previously been made public other than through a breach of this Agreement by the issuing Party and (B) such press release or public announcement does not
materially differ from the previously issued press release or other publicly available information. The Cooperating Party may notify the Requesting Party of any reasonable objections or suggestions that the Cooperating Party may have regarding the
proposed press release or public announcement, and the Requesting Party shall reasonably consider any such objections or suggestions that are provided in a timely manner. The principles to be observed in such disclosures shall include accuracy,
compliance with applicable Law and regulatory guidance documents, reasonable sensitivity to potential negative reactions of the FDA (and its foreign counterparts) and the need to keep investors informed regarding the Requesting Party’s
business. 
 Section 11.4 Publications. The Parties agree that decisions regarding the timing and content of Publications shall
be subject to the oversight and approval by Mutual Consent of the JSC and JPC and neither Party nor its Affiliates shall have the right to make Publications pertaining to the Collaboration except as provided herein. If a Party or its Affiliates
desire to make a Publication, such Party must comply with the following procedure: 
 (a) JSC Review. The publishing Party shall
provide the JSC and the non-publishing Party with an advance copy of the proposed Publication, and the JSC, by Mutual Consent, shall then have [**] days prior to submission for any Publication ([**] days in the case of an abstract or oral
presentation) in which to determine whether the Publication may be published and under what conditions, including (i) delaying sufficiently long to permit the timely preparation and filing of a patent application or (ii) specifying changes
the JSC reasonably believes are necessary to preserve any Patent Rights or Know-How belonging (whether through ownership or license, including under this Agreement) in whole or in part to the non-publishing Party. 

(b) Removal of Confidential Information. In addition, if the non-publishing Party informs the publishing Party that such Publication,
in the non-publishing Party’s reasonable judgment, discloses any Confidential Information of the non-publishing Party or could be expected to have a material adverse effect on any Know-How which is Confidential Information of the non-publishing
Party, such Confidential Information or Know-How shall be deleted from the Publication. 
 (c) Scientific Conferences. Each Party
shall have the right to present its Publications approved pursuant to this Section 11.4 at scientific conferences, including at any conferences in any country in the world, subject to any conditions imposed by the JSC in its approval. 

(d) Academic Publications. Notwithstanding the foregoing, the Parties acknowledge that, to the extent that any Publication relates to
Agios Intellectual Property that is subject to the Existing Third Party Agreement, the parties to such Existing Third Party 

  
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Agreement may have retained the right to publish certain information, and nothing in this Section 11.4 is intended to restrict the exercise of such rights; provided that, to
the extent that Agios has the right to review and comment on any such publications, Agios shall, to the extent permissible under such Existing Third Party Agreement, exercise such rights after consultation with Celgene. 

(e) Delegation. For purposes of convenience, the JSC may by Mutual Consent delegate its responsibilities under this Section 11.4
to one or more representatives of Agios and Celgene. 
 Section 11.5 Term. All obligations under this Article XI shall expire
[**] years following termination or expiration of this Agreement. 
 Section 11.6 Return of Confidential Information. 

(a) Obligations to Return or Destroy. Upon the expiration or termination of this Agreement, the Receiving Party shall return to the
Disclosing Party all Confidential Information received by the Receiving Party from the Disclosing Party (and all copies and reproductions thereof). In addition, the Receiving Party shall destroy: 

(i) any notes, reports or other documents prepared by the Receiving Party which contain Confidential Information of the Disclosing Party; and

 (ii) any Confidential Information of the Disclosing Party (and all copies and reproductions thereof) which is in electronic form or
cannot otherwise be returned to the Disclosing Party. 
 (b) Destruction. Alternatively, upon written request of the Disclosing
Party, the Receiving Party shall destroy all Confidential Information received by the Receiving Party from the Disclosing Party (and all copies and reproductions thereof) and any notes, reports or other documents prepared by the Receiving Party
which contain Confidential Information of the Disclosing Party. Any requested destruction of Confidential Information shall be certified in writing to the Disclosing Party by an authorized officer of the Receiving Party supervising such destruction.

 (c) Limitation. Nothing in this Section 11.6 shall require the alteration, modification, deletion or destruction of archival
tapes or other electronic back-up media made in the ordinary course of business; provided that the Receiving Party shall continue to be bound by its obligations of confidentiality and other obligations under this Article XI with
respect to any Confidential Information contained in such archival tapes or other electronic back-up media. 
 (d) Exceptions.
Notwithstanding the foregoing, 
 (i) the Receiving Party’s legal counsel may retain one copy of the Disclosing Party’s
Confidential Information solely for the purpose of determining the Receiving Party’s continuing obligations under this Article XI; and 

  
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 (ii) the Receiving Party may retain the Disclosing Party’s Confidential Information and its
own notes, reports and other documents 
 (A) to the extent reasonably required (1) to exercise the rights and licenses of the
Receiving Party expressly surviving expiration or termination of this Agreement; or (2) to perform the obligations of the Receiving Party expressly surviving expiration or termination of this Agreement; or 

(B) to the extent it is impracticable to do so without incurring disproportionate cost. 

Notwithstanding the return or destruction of the Disclosing Party’s Confidential Information, the Receiving Party shall continue to be bound by its
obligations of confidentiality and other obligations under this Article XI. 
 Article XII 

Representations and Warranties 

Section 12.1 Mutual Representations. Agios and Celgene each represents, warrants and covenants to the other Party, as of the
Effective Date, that: 
 (a) Authority. It has full corporate right, power and authority to enter into this Agreement and to perform
its obligations under this Agreement. 
 (b) Consents. Except as provided in Section 15.17, all necessary consents, approvals
and authorizations of all government authorities and other Persons required to be obtained by it as of the Effective Date in connection with the execution, delivery and performance of this Agreement have been or shall be obtained by the Effective
Date. 
 (c) No Conflicts. Notwithstanding anything to the contrary in this Agreement, the execution and delivery of this Agreement,
the performance of such Party’s obligations in the conduct of the Collaboration and the licenses and sublicenses to be granted pursuant to this Agreement (i) do not and will not conflict with or violate any requirement of applicable Laws
existing as of the Effective Date and (ii) do not and will not conflict with, violate, breach or constitute a default under any contractual obligations of such Party or any of its Affiliates existing as of the Effective Date. It has not used,
and during the Term will not knowingly use, any Know-How that is encumbered by any contractual right of or obligation to a Third Party that conflicts or interferes with any of the rights or licenses granted or to be granted to the other Party
hereunder. It has not granted, and during the Term it will not grant, any right or license, to any Third Party relating to any of the intellectual property rights it Controls, that conflicts with the rights or licenses granted or to be granted to
the other Party hereunder. 
 (d) Enforceability. This Agreement is a legal and valid obligation binding upon it and is enforceable
in accordance with its terms. 
 (e) Employee Obligations. To its knowledge, none of its or its Affiliates’ employees who have
been, are or will be involved in the Collaboration are, as a result of the nature of such Collaboration to be conducted by the Parties, in violation of any covenant in any contract with a Third Party relating to non-disclosure of proprietary
information, non-competition or non-solicitation. 

  
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 Section 12.2 Additional Agios Representations. Agios represents, warrants and
covenants to Celgene, as of the Effective Date, as follows: 
 (a) Agios possesses sufficient rights to enable Agios to grant all rights and
licenses it purports to grant to Celgene with respect to the Agios Intellectual Property under this Agreement. 
 (b) The Agios Patent
Rights existing as of the Effective Date constitute all of the Patent Rights Controlled by Agios or AIS as of such date that are necessary or useful for the Development, Manufacture or Commercialization of the Licensed Products. 

(c) There is no pending litigation, and Agios has not received any written notice of any claims or litigation, seeking to invalidate or
otherwise challenge the Agios Patent Rights or Agios’ rights therein. 
 (d) There is no pending litigation, and Agios has not received
any written notice of any claims or litigation, that alleges that Agios’ activities with respect to IDH1 or IDH2 have infringed or misappropriated any intellectual property rights of any Third Party. 

(e) [**] practice of the Agios Intellectual Property as contemplated under this Agreement does not (i) infringe any claims of any Patent
Rights of any Third Party, or (ii) misappropriate any Know-How of any Third Party. 
 (f) None of (i) the Agios Patent Rights
owned by Agios or both Controlled by and Prosecuted by Agios and (ii) [**], the Agios Patent Rights Controlled but not Prosecuted by Agios are subject to any pending re-examination, opposition, interference or litigation proceedings. 

(g) All of (i) the Agios Patent Rights owned by Agios or both Controlled by and Prosecuted by Agios and (ii) [**], the Agios Patent
Rights Controlled but not Prosecuted by Agios have been filed and diligently Prosecuted in accordance with all applicable Laws in the Territory and have been maintained, with all applicable fees with respect thereto having been paid. 

(h) True and correct copies of the Existing Third Party Agreement have been provided to Celgene, and such agreement is in full force and
effect and have not been modified or amended. Neither Agios nor, [**], any licensor under the Existing Third Party Agreement is in default with respect to a material obligation under, and none of such parties has claimed or has grounds upon which to
claim that the other party is in default with respect to a material obligation under, the Existing Third Party Agreement. 
 (i) [**] Agios
Patent Rights Controlled by Agios pursuant to the Existing Third Party Agreement were not and are not subject to any restrictions or limitations except as set forth in the Existing Third Party Agreement. 

  
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 (j) Agios has not waived or allowed to lapse any of its rights under the Existing Third Party
Agreement with respect to the Licensed Products, and no such rights have lapsed or otherwise expired or been terminated. 
 (k) Agios has
and, [**], the applicable licensor under the Existing Third Party Agreement has complied with any and all obligations under [**] to perfect rights to the applicable Patent Rights or Know-How licensed thereunder. 

(l) Agios has not employed and, to its knowledge, has not used a contractor or consultant that has employed, any individual or entity
(i) debarred by the FDA (or subject to a similar sanction of another applicable Regulatory Authority), (ii) who is the subject of an FDA debarment investigation or proceeding (or similar proceeding of another applicable Regulatory
Authority), or (iii) has been charged with or convicted under United States Law for conduct relating to the development or approval, or otherwise relating to the regulation of any Licensed Product under the Generic Drug Enforcement Act of 1992,
in each case, in the conduct of its activities prior to the Effective Date. 
 Section 12.3 Additional Celgene Representations.
Celgene represents, warrants and covenants to Agios, as of the Effective Date, as follows: 
 (a) Celgene possesses sufficient rights to
enable Celgene to grant all rights and licenses it purports to grant to Agios with respect to the Celgene Intellectual Property under this Agreement. 

(b) Celgene has not employed and, to its knowledge, has not used a contractor or consultant that has employed, any individual or entity
(i) debarred by the FDA (or subject to a similar sanction of another applicable Regulatory Authority), (ii) who is the subject of an FDA debarment investigation or proceeding (or similar proceeding of another applicable Regulatory
Authority), or (iii) has been charged with or convicted under United States Law for conduct relating to the development or approval, or otherwise relating to the regulation of any Licensed Product under the Generic Drug Enforcement Act of 1992,
in each case, in the conduct of its activities prior to the Effective Date. 
 Section 12.4 Employee Obligations. Agios and
Celgene each covenants to the other Party that all of its and its Affiliates’ employees, officers, consultants and advisors who have been, are or will be involved in the Collaboration have executed (or, prior to becoming involved in the
Collaboration, will have executed agreements) or have existing obligations under Law requiring assignment to such Party of all intellectual property made during the course of and as the result of their association with such Party, and obligating the
individual to maintain as confidential such Party’s Confidential Information, to the extent required to support such Party’s obligations under this Agreement. 

Section 12.5 No Warranties. EXCEPT AS OTHERWISE EXPRESSLY SET FORTH HEREIN, THE PARTIES MAKE NO REPRESENTATIONS AND EXTEND NO
WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING ANY REPRESENTATIONS OR WARRANTIES AS TO MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR NONINFRINGEMENT. 

  
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 Article XIII 

Indemnification; Product Liabilities 

Section 13.1 By Celgene. 

(a) Celgene Indemnification Obligation. Celgene agrees, at Celgene’s cost and expense, to defend, indemnify and hold harmless
Agios and its Affiliates and their respective directors, officers, employees and agents (the “Agios Indemnified Parties”) from and against any losses, costs, damages, fees or expenses arising out of any Third Party claim relating
to: 
 (i) any breach by Celgene of any of its representations, warranties or obligations pursuant to this Agreement; or 

(ii) the gross negligence, or willful misconduct or violation of Law of Celgene or its Affiliates. 

(b) Indemnification Procedures. In the event of any such claim against the Agios Indemnified Parties by any Third Party, Agios shall
promptly, and in any event within [**] Business Days, notify Celgene in writing of the claim. Celgene shall have the right, exercisable by notice to Agios within [**] Business Days after receipt of notice from Agios of the claim, to assume direction
and control of the defense, litigation, settlement, appeal or other disposition of the claim (including the right to settle the claim solely for monetary consideration) with counsel selected by Celgene and reasonably acceptable to Agios;
provided that the failure to provide timely notice of a claim by a Third Party shall not limit an Agios Indemnified Party’s right for indemnification hereunder except to the extent such failure results in actual prejudice to
Celgene. The Agios Indemnified Parties shall cooperate with Celgene and may, at their option and expense, be separately represented in any such action or proceeding. Celgene shall not be liable for any litigation costs or expenses incurred by the
Agios Indemnified Parties without Celgene’s prior written authorization. In addition, Celgene shall not be responsible for the indemnification or defense of any Agios Indemnified Party to the extent arising from any negligent or intentional
acts by any Agios Indemnified Party or the breach by Agios of any representation, obligation or warranty under this Agreement, or any claims compromised or settled without its prior written consent. 

Section 13.2 By Agios. 

(a) Agios Indemnification Obligation. Agios agrees, at Agios’ cost and expense, to defend, indemnify and hold harmless Celgene and
its Affiliates and their respective directors, officers, employees and agents (the “Celgene Indemnified Parties”) from and against any losses, costs, damages, fees or expenses arising out of any Third Party claim relating to: 

(i) any breach by Agios of any of its representations, warranties or obligations pursuant to this Agreement; or 

(ii) the gross negligence, willful misconduct or violation of Law of Agios or its Affiliates. 

  
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 (b) Indemnification Procedures. In the event of any such claim against the Celgene
Indemnified Parties by any Third Party, Celgene shall promptly, and in any event within [**] Business Days, notify Agios in writing of the claim. Agios shall have the right, exercisable by notice to Celgene within [**] Business Days after receipt of
notice from Celgene of the claim, to assume direction and control of the defense, litigation, settlement, appeal or other disposition of the claim (including the right to settle the claim solely for monetary consideration) with counsel selected by
Agios and reasonably acceptable to Celgene; provided that the failure to provide timely notice of a claim by a Third Party shall not limit a Celgene Indemnified Party’s right for indemnification hereunder except to the extent such
failure results in actual prejudice to Agios. The Celgene Indemnified Parties shall cooperate with Agios and may, at their option and expense, be separately represented in any such action or proceeding. Agios shall not be liable for any litigation
costs or expenses incurred by the Celgene Indemnified Parties without Agios’ prior written authorization. In addition, Agios shall not be responsible for the indemnification or defense of any Celgene Indemnified Party to the extent arising from
any negligent or intentional acts by any Celgene Indemnified Party or the breach by Celgene of any representation, obligation or warranty under this Agreement, or any claims compromised or settled without its prior written consent. 

Section 13.3 Product Liability Costs. Except with respect to such portion (if any) of Product Liabilities that are claims entitled
to indemnification under Section 13.1 or Section 13.2, the Parties shall be responsible for all Product Liabilities, all Out-of-Pocket Costs and FTE Costs incurred by the controlling Party under Section 13.4 in connection with any
litigation or proceeding related to such Third Party Products Liability Action, and all Out-of-Pocket Costs and FTE Costs incurred by the non-controlling Party under Section 13.4 at the request of the controlling Party under Section 13.4
as follows: 
 (a) All such costs and expenses incurred before the Agios Opt-Out Date shall be taken into account in determining US
Territory Profit or Loss as, and to the extent, provided in the Financial Exhibit. 
 (b) All such costs and expenses incurred after the
Agios Opt-Out Date relating to Licensed Products in the US Territory shall be borne solely by Celgene if and only to the extent such Product Liabilities were caused by the occurrence after the Agios Opt-Out Date of the event, incident or
circumstance that led to the Third Party Liability Action. 
 (c) All such costs and expenses incurred after the Agios Opt-Out Date relating
to Licensed Products in the US Territory shall be borne fifty per cent (50%) by each of the Parties to the extent such Product Liabilities were caused by the occurrence before the Agios Opt-Out Date of an event, incident or circumstance that is
the subject of the Third Party Liability Action. If Agios is invoiced for its portion of such costs and expenses incurred after the Agios Opt-Out Date, payment is due within [**] days of receipt of invoice. 

Section 13.4 Conduct of Product Liability Claims. 

(a) Each Party shall promptly notify the other in the event that any Third Party asserts or files in the US Territory any products liability
claim or other action relating to alleged defects in the Licensed Product (whether design defects, manufacturing defects or 

  
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defects in sales or marketing) (“Third Party Products Liability Action”) against such Party. In the event of a Third Party Products Liability Action against such a single Party,
the unnamed Party shall have the right, in the unnamed Party’s sole discretion, to join or otherwise participate in such legal action with legal counsel selected by the unnamed Party and reasonably acceptable to the named Party. The Party named
in such Third Party Products Liability Action shall have the right to control the defense of the action, but shall notify and keep the unnamed Party apprised in writing of such action and shall consider and take into account the unnamed Party’s
reasonable interests and requests and suggestions regarding the defense of such action; provided that, in the event of an Agios Opt-Out Notice, Celgene shall have the right to control the defense of all Third Party Product Liability
Actions after the Agios Opt-Out Date. In the event of a Third Party Products Liability Action against both Parties, the Parties shall attempt to mutually agree upon which Party shall control the response to such Third Party Products Liability
Action; provided that, in the event of an Agios Opt-Out Notice or the failure of the Parties to mutually agree otherwise, Celgene shall have the right to control the defense of all Third Party Product Liability Actions. 

(b) The non-controlling Party of a Third Party Products Liability Action shall reasonably cooperate with the controlling Party in the
preparation and formulation of a defense to such Third Party Products Liability Action, and in taking other steps reasonably necessary to respond to such Third Party Products Liability Action. The controlling Party shall have the right to select its
counsel for the defense to such Third Party Products Liability Action, which counsel must be reasonably acceptable to the non-controlling Party. If required under applicable Law in order for the controlling Party to maintain a suit in response to
such Third Party Products Liability Action, the non-controlling Party shall join as a party to the suit. Subject to Section 13.3, each Party shall be responsible for its own Out-of-Pocket Costs incurred in connection with any litigation or
proceedings related to such Third Party Products Liability Action, including the fees and expenses of the counsel selected by the controlling Party. The non-controlling Party shall also have the right to participate and be represented in any such
suit by its own counsel at its own expense. The controlling Party shall not settle or compromise any Third Party Products Liability Action without the consent of the other Party, which consent shall not be unreasonably withheld. 

Section 13.5 Limitation of Liability. EXCEPT WITH RESPECT TO A BREACH OF SECTION 8.6 OR ARTICLE XI, OR A PARTY’S LIABILITY
PURSUANT TO SECTION 13.1 OR 13.2, NEITHER PARTY SHALL BE LIABLE FOR SPECIAL, CONSEQUENTIAL, EXEMPLARY, PUNITIVE, MULTIPLE OR OTHER INDIRECT OR REMOTE DAMAGES, OR FOR LOSS OF PROFITS, LOSS OF DATA OR LOSS OF USE DAMAGES ARISING IN ANY WAY OUT OF THIS
AGREEMENT OR THE EXERCISE OF ITS RIGHTS HEREUNDER, WHETHER BASED UPON WARRANTY, CONTRACT, TORT, STRICT LIABILITY OR OTHERWISE, EVEN IF SUCH PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES OR LOSS. 

Section 13.6 Insurance. Beginning on [**] and thereafter during the Term, each Party shall maintain commercial general liability
insurance (including product liability insurance) from a recognized, creditworthy insurance company, with coverage limits of at least $[**] per claim and annual aggregate. Celgene may elect to self-insure all or parts of the limits described above.
Within [**] days following written request from the other Party, each Party shall furnish to the 

  
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other Party a certificate of insurance evidencing such coverage. If such coverage is modified or cancelled, the insured Party shall notify the other Party and promptly provide such other Party
with a new certificate of insurance evidencing that such insured Party’s coverage meets the requirements of this Section 13.6. 

Article XIV 
 Term and
Termination 
 Section 14.1 Term. The term of this Agreement (the “Term”) shall commence on the Effective
Date and shall continue, unless earlier terminated pursuant to Section 2.12(b) or 14.2, in full force and effect as long as the Parties continue to Develop and/or Commercialize Licensed Products in accordance with the terms and conditions of
this Agreement, or, in the event of an Agios Opt-Out Date, until expiration of the Royalty Term for all Licensed Products. 

Section 14.2 Termination. 

(a) Termination for Convenience. Celgene shall have the right to terminate this Agreement in its entirety for convenience upon ninety
(90) days’ prior written notice to Agios; provided that Celgene shall not have the right to terminate this Agreement until twelve (12) months following the Effective Date. 

(b) Termination for Material Breach or Insolvency. 

(i) If either Party (the “Non-Breaching Party”) believes that the other Party (the “Breaching Party”) is in
material breach of this Agreement, then the Non-Breaching Party may deliver written notice of such breach to the Breaching Party. If the Breaching Party fails to cure such breach, or take such steps as would be considered reasonable to effectively
cure such breach, within the [**] day period after delivery of such notice, the Non-Breaching Party may terminate this Agreement upon written notice to the Breaching Party. Notwithstanding the foregoing, if such breach is capable of being cured, but
is not reasonably capable of being cured within the [**]-day cure period, if the Breaching Party (A) proposes within such [**]-day period a written plan to cure such breach within a defined time frame extending for a period not to exceed an
additional [**] days, and (B) makes good faith efforts to cure such default and to implement such written cure plan, then the Non-Breaching Party may not terminate this Agreement until the earlier of such time as the Breaching Party is no
longer diligently pursuing such cure in accordance with such plan or the end of such additional period. 
 (ii) To the extent permitted by
Law, this Agreement may be terminated by either Party upon the filing or institution of bankruptcy, reorganization, liquidation or receivership proceedings, or upon an assignment of a substantial portion of the assets for the benefit of creditors by
the other Party; provided, however, that, in the event of any involuntary bankruptcy or receivership proceeding such right to terminate shall only become effective if the Party consents to the involuntary bankruptcy or
receivership or such proceeding is not dismissed within ninety (90) days after the filing thereof. 
 (c) Termination of AGI-23088
ROW Agreement. This Agreement terminates automatically if the AGI-23088 ROW Agreement terminates for any reason. The AGI-23088 ROW Agreement terminates if this Agreement terminates for any reason. 

  
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 Section 14.3 Effects Of Termination. 

(a) Effects of Celgene Termination for Convenience or Agios Termination for Celgene Breach or Insolvency. Upon termination of this
Agreement by Celgene under Section 14.2(a), by Agios under Section 14.2(b), as a result of termination of the AGI-23088 ROW Agreement by CIS II under Section 14.2(a) for Celgene CIS II convenience therein, or as a result of
termination of the AGI-23088 ROW Agreement by AIS under Section 14.2(b) for CIS II breach therein, the following shall apply: 

(i) all licenses granted by Agios to Celgene under Section 8.1(a) shall terminate, and all licenses granted by Celgene to Agios
under Section 8.1(b) shall remain in effect and, from and after such termination, Agios shall pay Celgene royalties on Annual Net Sales of Licensed Products in the US Territory pursuant to Section 9.5 substituting “Agios” for
“Celgene” and vice versa with respect to all obligations and definitions, and otherwise mutatis mutandis, with the Agios Opt-Out Date, as used therein, deemed to be the effective date of termination;  

(ii) each Party shall be released from its Development, Manufacture and Commercialization obligations (except as set forth in
Section 14.3(a)(vii) and (viii) below with respect to Celgene’s transfer of Manufacturing to Agios hereunder); 
 (iii)
within [**] days after such termination, unless there has been an Agios Opt-Out Date, each Party shall provide the other with a report of Development Costs, Net Sales and Commercialization Expenses and other amounts incurred by such Party that are
subject to the Parties’ cost-sharing obligations through the effective date of termination for the purpose of calculating a final reconciliation of shared costs and payments in accordance with Sections 9.2 and 9.4, as applicable. Each Party
shall submit any supporting information reasonably requested by the other Party related to such Development Costs, Net Sales, Commercialization Expenses and such other amounts included in such Party’s reconciliation report within [**] days
after the other Party’s receipt of such request. The Parties, with the assistance of the Finance Working Group, shall conduct a final reconciliation of such costs and payments within [**] days after receipt of all such supporting information,
and an invoice shall be issued to the Party (if any) that owes the other Party a payment to accomplish the cost sharing or payment envisioned under this Agreement pursuant to Sections 9.2 and 9.4, as applicable. The paying Party shall pay all
amounts payable under any such invoice within [**] days after its receipt of such invoice; provided, however, that, Celgene shall remain responsible for its applicable share of the Developments Costs of any Clinical Trials or
other Development activities committed and not cancelable by Agios with respect to the Licensed Products prior to the effective date of termination to the extent such Development Costs are within an approved Development Budget under an approved
Development Plan in place prior to termination; 
 (iv) within [**] days after such termination, Celgene shall provide to Agios a fair and
accurate summary report of the status of Development and Commercialization activities conducted by Celgene with respect to the Licensed Products; 

(v) Celgene shall promptly transfer and assign to Agios all of Celgene’s and its Affiliates’ rights, title and interests in and to
the product trademark(s) (but not any Celgene house marks or composite marks including a house mark) owned by Celgene and solely used for Licensed Products in the US Territory; 

  
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 (vi) Celgene shall as soon as reasonably practicable transfer and assign to Agios all Regulatory
Approvals of the Licensed Products in the US Territory, their corresponding Regulatory Documentation, and a copy of all of the data comprising the Global Safety Database; provided that Celgene may retain such data and a single copy of
such Regulatory Approvals and Regulatory Documentation for its records; and provided further that, if such Regulatory Approvals or Regulatory Documentation are necessary or useful for the Development, Manufacture and/or
Commercialization of any product other than the Licensed Products, in place of transferring or assigning the foregoing, Celgene shall grant Agios a Right of Reference or Use with respect to such approvals or documentation with respect to the
Licensed Products in the US Territory; 
 (vii) Agios shall have the option, exercisable within [**] days following the effective date of
such termination of this Agreement, to obtain Celgene’s inventory of the Licensed Products at a price equal to one hundred five percent (105%) of Celgene’s Manufacturing Costs for such inventory of the Licensed Products;
provided that, if Celgene, its Affiliates or sublicensees have outstanding orders, at Agios’ election, either Agios shall fulfill such orders or, notwithstanding Agios’ option to purchase inventory, Celgene may retain
sufficient inventory to fulfill such orders. Agios may exercise such option by written notice to Celgene during such [**]day period; provided that, in the event Agios exercises such right to purchase such inventory, Celgene shall
grant, and hereby does grant, a royalty-free right and license to any trademarks, names and logos of Celgene contained therein for a period of [**] months solely to permit the orderly sale of such inventory, subject to Agios meeting reasonable
quality control standards imposed by Celgene on the use of such trademarks, names and logos, which shall be consistent with the standards used by Celgene prior to such termination; 

(viii) to the extent that Celgene is responsible for Manufacturing the Licensed Products immediately prior to such termination, at
Agios’ written request: 
 (A) in exchange for a payment equal to one hundred five percent (105%) of Celgene’s Manufacturing
Costs and upon other commercially reasonable terms as may be mutually agreed between the Parties or their respective Affiliates in a supply agreement, Celgene shall use Commercially Reasonable Efforts to supply Agios and its Affiliates with
comparable quantities of the Licensed Products in the form, formulation and presentation as were being Developed or Commercialized immediately prior to termination until the earlier of [**] months after the effective date of the termination and
establishment by Agios of an alternative supply for such product(s); 
 (B) in the event Celgene was utilizing a Third Party manufacturer
to Manufacture the Licensed Products, to the extent permitted by the terms of such contract, Celgene shall promptly assign to Agios the manufacturing agreements with such Third Party with respect to such product(s); and 

(C) Celgene shall transfer, or have transferred, to Agios or its designee, pursuant to a technology transfer plan to be mutually agreed by
the Parties, all 

  
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Manufacturing Technology Controlled by Celgene or CIS II within Celgene Collaboration Intellectual Property that is both necessary to Manufacture the Licensed Products as Manufactured by or on
behalf of Celgene and its Affiliates prior to termination and has been incorporated in regulatory documentation submitted to a Regulatory Authority in support of Development or Commercialization of the Licensed Products (or is in the process of
being incorporated), and Celgene shall provide reasonable assistance in connection with the transfer of such Manufacturing Technology to Agios or its designee, all of which shall be transferred or provided at Celgene’s Out-of-Pocket Costs; 

(ix) notwithstanding anything to the contrary in Section 8.6, Agios shall have the right to pursue the Development, Manufacture and
Commercialization of the Licensed Products, provided, however, that in the event of a termination under Section 14.2(a) by Celgene, if Agios or any of its Affiliates propose(s) to take or take(s) any action not contemplated
by the Development Plan in effect at the time of such termination, and that Celgene reasonably determines is reasonably likely to have a material adverse impact on the Commercialization of any of the “Licensed Products,” as such term is
defined in the 2010 Agreement, then Celgene shall provide written notice to such effect to Agios specifying in reasonable detail which actions by Agios or its Affiliates would have such an effect, and what such effect would be. The Parties shall use
good faith efforts to discuss the pertinent actions and resolve the matter. If Agios concurs with Celgene’s determination, Agios and its Affiliates shall not proceed with, or shall cease as quickly as reasonably possible, as applicable, such
action without the written consent of Celgene. If Agios does not concur with Celgene’s determination, Celgene may present the issue to the Executive Officers for resolution pursuant to Section 15.1(a) and, if agreement is not reached, may
seek resolution of such matter in accordance with Section 15.1(b). If Celgene does present the issue to the Executive Officers for resolution, then Agios and its Affiliates shall not proceed with, or shall cease as quickly as reasonably
possible, as applicable, such action until the dispute is resolved by agreement of the Executive Officers or in accordance with Section 15.1(b); and 

(x) the provisions of Article X (other than Section 10.1) terminate, and Celgene shall, if applicable, provide reasonable assistance to
Agios and cooperation in connection with the transition of Prosecution and enforcement responsibilities to Agios with respect to Agios Patents Rights and Collaboration Patent Rights then being Prosecuted or enforced by Celgene, including execution
of such documents as may be necessary to effect such transition. 
 (b) Effects of Celgene Termination for Agios Breach. Upon any
termination of this Agreement by Celgene under Section 14.2(b) or as a result of termination of the AGI-23088 ROW Agreement by CIS II under Section 14.2(b) for breach by AIS therein: 

(i) all future milestones payable by Celgene under Section 9.3 shall be reduced by fifty percent (50%) of the otherwise applicable
payment amounts; provided that, if the termination of this Agreement is as a result of Agios’ breach of Section 8.6, all future milestones payable by Celgene under Section 9.3 shall terminate; 

(ii) from and after such termination, if the Agios Opt-Out Date has not occurred before the effective date of termination, then Celgene shall
pay Agios royalties on 

  
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Annual Net Sales of Licensed Products in the US Territory pursuant to Section 9.5, with the Agios Opt-Out Date, as used therein, deemed to be the effective date of termination, and if the
Agios Opt-Out Date has occurred before the effective date of termination, then Celgene shall continue to pay to Agios royalties on Annual Net Sales of Licensed Products in the US Territory but the applicable royalty rate(s) shall be reduced by fifty
percent (50%) of the otherwise applicable rate(s); 
 (iii) all licenses granted by Celgene to Agios under Sections 8.1(b) with
respect to the Licensed Products shall terminate; 
 (iv) each Party shall be released from its Development, Manufacture and
Commercialization obligations (except as set forth in clause (viii) below with respect to Agios’ transfer of Manufacturing to Celgene hereunder); 

(v) each Party shall provide the other with a report of the Development Costs and Commercialization Expenses incurred by such Party that are
subject to the Parties’ cost-sharing obligations through the effective date of termination for the purpose of calculating a final reconciliation of shared costs in accordance with Section 9.2 and 9.4; provided, however,
that, Agios shall remain responsible for its applicable share of the Developments Costs of any Clinical Trials or other Development activities committed by the Parties with respect to the Licensed Products prior to the effective date of
termination to the extent such Development Costs are within an approved Development Budget under an approved Development Plan in place prior to termination; 

(vi) within [**] days after such termination, Agios shall provide to Celgene a fair and accurate summary report of the status of Development
and Commercialization activities conducted by Agios with respect to the Licensed Products; 
 (vii) the license granted by Agios to Celgene
in Section 8.1(a) shall immediately become an exclusive (even as to Agios) license for the entire US Territory, which license shall continue in full force in perpetuity; provided that Celgene shall be solely responsible for any
payments owed by Agios to any Third Party licensors of Agios Intellectual Property or Agios Collaboration Intellectual Property and shall be responsible for complying with the terms of any license agreements with such Third Party licensors, in
either case, directly related to Celgene’s exercise of such license; 
 (viii) the provisions of Section 14.3(a)(v), (vi),
(vii) and (viii), shall apply, in each case, substituting “Agios” for “Celgene” and vice versa with respect to all obligations and definitions, and otherwise mutatis mutandis; 

(ix) notwithstanding anything to the contrary in Section 8.6, Celgene shall have the right to pursue the Development, Manufacture and
Commercialization of the Licensed Products, provided, however, that if Celgene or any of its Affiliates propose(s) to take or take(s) any action not contemplated by the Development Plan in effect at the time of such termination,
and that Agios reasonably determines is reasonably likely to have a material adverse impact on the Commercialization of any of the “Licensed Products,” as such term is defined in the 2010 Agreement, then Agios shall provide written notice
to such effect to Celgene specifying 

  
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in reasonable detail which actions by Celgene or its Affiliates would have such an effect, and what such effect would be. The Parties shall use good faith efforts to discuss the pertinent actions
and resolve the matter. If Celgene concurs with Agios’ determination, Celgene and its Affiliates shall not proceed with, or shall cease as quickly as reasonably possible, as applicable, such action without the written consent of Agios. If
Celgene does not concur with Agios’ determination, Celgene may present the issue to the Executive Officers for resolution pursuant to Section 15.1(a) and, if agreement is not reached, may seek resolution of such matter in accordance with
Section 15.1(b). If Agios does present the issue to the Executive Officers for resolution, then Celgene and its Affiliates shall not proceed with, or shall cease as quickly as reasonably possible, as applicable, such action until the dispute is
resolved by agreement of the Executive Officers or in accordance with Section 15.1(b); and 
 (x) the rights of Agios in Article X
(other than Section 10.1) shall be terminated and Agios shall, if applicable, provide reasonable assistance to Celgene and cooperation in connection with the transition of Prosecution and enforcement responsibilities to Celgene with respect to
Agios Patents Rights and Agios Collaboration Patent Rights and all Joint Inventions and Joint Patents, including execution of such documents as may be necessary to effect such transition. 

(c) Sell-Down. Unless Agios exercises its option under Section 14.3(a)(vii), if Celgene, its Affiliates or sublicensees at
termination of this Agreement possess Licensed Product, have started the manufacture thereof or have accepted orders therefor, Celgene, its Affiliates or sublicensees shall have the right, for up to [**] following the date of termination, to sell
their inventories thereof, complete the manufacture thereof and Commercialize such fully-manufactured Licensed Product, in order to fulfill such accepted orders or distribute such fully-manufactured Licensed Product, subject to the obligation of
Celgene to pay Agios any and all payments as provided in this Agreement. 
 (d) Survival. Upon any termination or expiration of this
Agreement, unless otherwise specified in this Agreement and except for any rights or obligations that have accrued prior to the effective date of termination or expiration, all rights and obligations of each Party under this Agreement shall
terminate in whole or with respect to the Licensed Products, as the case may be; provided, however, that Sections 2.1(b), 3.4(b), 8.3(f), 8.7, 8.8, 9.2(b), 9.5(b)(v), 9.7, 9.8, 9.9, 10.1, 12.5, 13.6 (for at least [**]) and this
Section 14.3 and Articles IX (to the extent any amounts are due but unpaid), XI, XIII (other than Section 13.6 (Insurance)) and XV, as well as any other provision which by its terms or by the context thereof is intended to survive, shall
survive any such termination or expiration of this Agreement. 
 (e) Equitable Relief. Termination of this Agreement shall be in
addition to, and shall not prejudice, the Parties’ remedies at law or in equity, including the Parties’ ability to receive legal damages and/or equitable relief with respect to any breach of this Agreement, regardless of whether or not
such breach was the reason for the termination. 
 (f) Accrued Liabilities. Except as otherwise specifically provided herein,
termination of this Agreement shall not relieve the Parties of any liability or obligation which accrued hereunder prior to the effective date of such termination, nor preclude either Party from pursuing all rights and remedies it may have hereunder
or at law or in equity with respect to any 

  
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breach of this Agreement nor prejudice either Party’s right to obtain performance of any obligation. In addition, termination of this Agreement shall not terminate provisions which provide
by their respective terms for obligations or undertakings following the expiration of the term of this Agreement. 
 Article XV 

Miscellaneous 

Section 15.1 Dispute Resolution. 

(a) Except for any disagreements that are within the authority of any Committee as provided in Article II (which disagreements shall be
resolved in accordance with Section 2.8), the Parties agree that any disputes arising with respect to the interpretation, enforcement, termination or invalidity of this Agreement (each, a “Dispute”) shall first be presented to
the Parties’ respective Executive Officers for resolution. If the Parties are unable to resolve a given dispute pursuant to this Section 15.1(a) after in-person discussions between the Executive Officers within [**] Business Days after
referring such dispute to the Executive Officers, either Party may, at its sole discretion, seek resolution of such matter in accordance with Section 15.1(b) or Section 15.2, as applicable. 

(b) If the Parties do not resolve a Dispute with respect to any Arbitrable Matter after referring such matter to the Executive Officers
pursuant to Section 15.1(a), then either Party may request that such Dispute be resolved by binding arbitration in accordance with the expedited procedures applicable to the Commercial Arbitration Rules of the American Arbitration Association
(the “AAA”) and the provisions of this Section 15.1(b). Dispute resolution pursuant to this Section 15.1(b) shall apply only to the following Disputes if the Parties cannot agree by Mutual Consent (“Arbitrable
Matters”): (x) whether an action proposed to taken by a Party or its Affiliate pursuant to Section 2.12(b)(ii), 6.1(b)(i), 14.3(a)(ix) or 14.3(b)(ix) is reasonably likely to have a material adverse impact on the Commercialization
of any of the “Licensed Products,” as such term is defined in the 2010 Agreement; or (y) whether an action proposed to be taken by Agios or its Affiliate pursuant to Section 6.1(b)(ii) is reasonably likely to have an adverse
impact on Commercialization of any of the “Licensed Products,” as such term is defined in the AGI-23088 ROW Agreement. 
 (i) The
Party desiring to initiate an arbitration proceeding with respect to an Arbitrable Matter will send a written notice to the other Party requesting the commencement of the arbitration proceeding and specifying the issue to be resolved. Within [**]
days after the date such notice is sent, the Parties shall negotiate in good faith to appoint a mutually acceptable independent person, with scientific, technical, and regulatory experience with respect to the development of pharmaceutical products
in the Field necessary to resolve such Dispute and with availability to comply with the time periods in this Section 15.1(b) (an “Expert”). If the Parties fail to choose an Expert within the foregoing time period, the AAA shall
choose an Expert (with such experience and availability) on behalf of the Parties within [**] days after receipt of written request by a Party to the AAA. Disputes about arbitration procedure will be resolved by the Expert or, failing agreement, by
the AAA in New York, New York. Unless otherwise agreed by the Parties, the arbitration proceedings will be conducted in New York, New York. The fees and costs of the Expert and the AAA, if applicable, shall be shared equally by the Parties. 

  
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 (ii) Within [**] days after selection of the Expert, each Party shall simultaneously deliver to
the Expert and the other Party a written statement: (A) stating each of the issues that is the subject of the Arbitrable Matter dispute, (B) setting forth such Party’s position on each issue in dispute, and (C) setting forth such
Party’s final position with respect to each such issue. With such statement, each Party may also submit supporting documentation, if any, for such Party’s final position. Each Party shall have [**] days after the other Party’s
submission to submit to the Expert and the other Party a written response thereto, which may include any scientific and technical information in support thereof. The Expert shall have the right to meet with the Parties, either alone or together, as
necessary to make a determination. 
 (iii) In resolving the dispute, the Expert will have no authority to make a decision on any issue
other than by selecting the final position of one of the Parties. An arbitration decision with respect to the Arbitrable Matter will be rendered in writing the designation of the Expert, which decision will be final and binding on the Parties. For
all purposes under this Agreement, any decision made pursuant to this Section 15.1(b) shall be deemed to be the decision of the Parties, by Mutual Consent. 

Section 15.2 Submission to Court for Resolution. Subject to Section 15.1, the Parties hereby irrevocably and unconditionally
consent to the exclusive jurisdiction of the courts located in the Southern District of New York for any action, suit or proceeding (other than appeals therefrom) arising out of or relating to this Agreement, and agree not to commence any action,
suit or proceeding (other than appeals therefrom) related thereto except in such courts. The Parties further hereby irrevocably and unconditionally waive any objection to the laying of venue of any action, suit or proceeding (other than appeals
therefrom) arising out of or relating to this Agreement in the courts of New York, and hereby further irrevocably and unconditionally waive and agree not to plead or claim in any such court that any such action, suit or proceeding brought in any
such court has been brought in an inconvenient forum. Each Party further agrees that service of any process, summons, notice or document by registered mail to its address set forth in Section 15.7 shall be effective service of process for any
action, suit or proceeding brought against it under this Agreement in any such court. 
 Section 15.3 Governing Law. This
Agreement and all questions regarding its validity or interpretation, or the performance or breach of this Agreement, shall be governed by and construed and enforced in accordance with the laws of the State of New York, without reference to
conflicts of laws principles. 
 Section 15.4 Assignment. 

(a) Right to Assign. Neither Party may assign this Agreement, in whole or in part, without the consent of the other Party, except that
either Party may assign this Agreement without the consent of the other Party, (i) in whole or in part, to any Affiliate of such Party, or (ii) in whole as part of a Change of Control of such Party; provided that the
assigning Party provides the other Party with written notice of such assignment and such assignee agrees in writing to be bound by the terms and conditions of this Agreement. The terms of this 

  
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Agreement shall be binding upon and shall inure to the benefit of the successors, heirs, administrators and permitted assigns of the Parties. Any purported assignment in violation of this
Section 15.4 shall be null and void. 
 (b) Acquisition of a Party. Each Party agrees that in the event that a Party (the
“Acquired Party”) is acquired by Change of Control (an “Acquisition”) by a Third Party (the “Acquirer”), (i) the non-Acquired Party shall not obtain any rights or access under this Agreement to
any Know-How or Patent Rights Controlled by such Acquirer which were not already within Agios Intellectual Property (if the Acquired Party is Agios) or Celgene Intellectual Property (if the Acquired Party is Celgene) immediately prior to the
consummation of such Acquisition; and (ii) the provisions of Section 8.6 shall not apply to any activity otherwise prohibited therein if a Party’s involvement in such prohibited activity results from the Acquirer’s activities but
only if (A) such Acquirer, prior to such acquisition or merger, was already engaged in such prohibited activity (the “Third Party Activity”), and (B) no Celgene Intellectual Property, Agios Intellectual Property, or
Collaboration Intellectual Property is used in connection with such Third Party Activity. 
 (c) Acquisition by a Party. Each Party
agrees that in the event that a Party acquires (whether by way of merger, acquisition, sale of all or substantially all of its business or assets to which this Agreement pertains, or otherwise) a Third Party (the “Acquired Third
Party”), the provisions of Section 8.6 shall not apply to any activity otherwise prohibited therein if a Party’s involvement in such prohibited activity results from such acquisition, but only if (i) such Acquired Third
Party, prior to such acquisition, was already engaged in such prohibited activity (the “Acquired Party Activity”), and (ii) the Party acquiring such Acquired Third Party shall, within [**] days after the date of the
consummation of such acquisition, notify the other Party of such acquisition and comply with the other provisions of this Section 15.4(c). Following consummation of such an acquisition, the acquiring Party shall, at its option, either
(A) use good faith efforts to identify a Third Party purchaser to whom such Party will divest its interest in the Acquired Party Activity and to enter into a definitive agreement with such Third Party for such divestiture as soon as reasonably
practicable under the circumstances, but such divestiture must be completed no later than [**] months after the closing of such Party’s acquisition of the Acquired Party Activity, or (B) promptly discontinue such Acquired Party Activity;
provided that notwithstanding which option is chosen, such divesture or discontinuation must be accomplished no later than [**] months after the closing of such Party’s acquisition of the Acquired Party Activity. During the time
period following the consummation of an acquisition covered by this Section 15.4(c) through the divestiture or discontinuation of the Acquired Party Activity, the acquiring Party shall not use any Celgene Intellectual Property, Agios
Intellectual Property, or Collaboration Intellectual Property in connection with such Acquired Party Activities. So long as the acquiring Party divests of, or discontinues, the Acquired Party Activity in accordance with this Section 15.4(c),
such acquisition shall not be deemed a violation of Section 8.6. 
 Section 15.5 Certain Additional Matters Relating to Change
of Control of a Party. In the event that either Party is subject to a Change of Control, such Party shall notify the other Party at least [**] Business Days prior to the consummation of such Change of Control (or such lesser period of time as is
practicable under the circumstances), and shall thereafter provide written notice to the other Party promptly following consummation of such Change of Control. 

(a) Agios Change of Control. Upon consummation of a Change of Control of Agios, the Collaboration shall continue in effect as provided
in this Agreement except that: 
 (i) the license and sublicense granted to Agios under Section 8.1(b) shall terminate; 

  
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 (ii) all decisions relating to Development, Manufacturing and Commercialization that require
decision by a Committee or that are subject to Mutual Consent shall be made solely by Celgene and all decisions for which Agios was provided with final decision-making authority under Section 2.8 shall be made solely by Celgene;
provided, however, that Celgene shall not exercise such decision-making authority in any manner that diminishes Agios’ rights with respect to Marketing Activities pursuant to Section 6.3; 

(iii) except as otherwise directed by Celgene and except with respect to Marketing Activities allocated to Agios pursuant to
Section 6.3, Agios shall cease to conduct any further Development or Commercialization activities with respect to any Licensed Products and cease to incur any further Development Costs or Commercialization Expenses except as approved by Celgene
or as provided in Sections 5.4, 13.3 and 13.4; 
 (iv) Agios shall provide to Celgene a reasonably detailed summary of Development and
Commercialization activities undertaken by Agios under the Collaboration, including any Clinical Trials committed but not yet completed as of such date; 

(v) Agios shall undertake, and coordinate with Celgene with respect to, any wind-down or transitional activities reasonably necessary to
transfer to Celgene all Development, Manufacturing (including all Agios Clinical-Scale Manufacturing Responsibilities and Agios Commercial-Scale Manufacturing Responsibilities) and Commercialization responsibility for the Licensed Products
throughout the US Territory (other than Marketing Activities allocated to Agios pursuant to Section 6.3), at Agios’ sole expense, including those activities referenced in Section 14.3(b)(viii); provided that the Parties
shall reasonably cooperate in seeking to minimize the costs of such wind-down or transitional activities; provided further that (A) if Celgene requests that any contracts or agreements that extend beyond consummation of the
Change of Control be terminated, Agios shall be responsible for all costs associated with such termination, and (B) if Celgene requests that any such contract or agreement remain in effect, Celgene shall be responsible for all Development Costs
and Commercialization Expenses under such contract or agreement following consummation of the Change of Control; 
 (vi) Celgene shall have
the option to obtain Agios’ inventory of the Licensed Products and their active pharmaceutical ingredients at a price equal to their Manufacturing Costs; 

(vii) in the event Agios is utilizing a Third Party manufacturer to Manufacture the Licensed Products or their active pharmaceutical
ingredients, to the extent permitted by the terms of such contract, Agios shall, if requested by Celgene, promptly assign to Celgene the manufacturing agreements with such Third Party with respect to such products and ingredients; 

  
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 (viii) Agios shall transfer, or have transferred, to Celgene or its designee, pursuant to a
technology transfer plan to be mutually agreed by the Parties, all Manufacturing Technology Controlled by Agios or AIS within Agios Intellectual Property that is both necessary to Manufacture the Licensed Products or their active pharmaceutical
ingredients as Manufactured by or on behalf of Agios and its Affiliates, and Agios shall provide reasonable assistance in connection with the transfer of such Manufacturing Technology to Celgene or its designee, all of which shall be deemed
Development Costs; 
 (ix) notwithstanding anything to the contrary in Section 2.8 or otherwise herein, Celgene shall have the right
to resolve all disputes within any Committee and final decision making authority on all unresolved matters throughout the US Territory; 

(x) all of Agios’ rights under Article X (other than Section 10.1) shall terminate, and Agios shall transition to Celgene all of
Agios’ Prosecution and enforcement responsibilities with respect to Agios Patents Rights, Agios Collaboration Patent Rights, Joint Inventions and Joint Patents, and provide reasonable assistance to Celgene and cooperation in connection
therewith, including execution of such documents as may be necessary to effect such transition, and Agios’ rights under Sections 10.2(a) and 10.2(d) on Prosecution matters all terminate notwithstanding anything to the contrary in Article X,
provided that Agios shall retain step-in rights under Sections 10.2(b) and Section 10.3(d) as well as comparable step-in rights on Prosecution matters relating to Agios Patent Rights and Agios Collaboration Patent Rights; and 

(xi) the AGI-23088 ROW Agreement will be affected in a corresponding manner as provided therein. 

(b) Celgene Change of Control. Upon consummation of a Change of Control of Celgene before the Agios Opt-Out Notice, the Collaboration
shall continue in effect as provided in this Agreement, except that: 
 (i) the license and sublicense granted to Celgene under
Section 8.1(a) shall terminate; 
 (ii) all decisions relating to Development, Manufacturing and Commercialization that require
decision by a Committee or that are subject to Mutual Consent shall be made solely by Agios and all decisions relating to Commercialization for which Celgene was provided with final decision-making authority under Section 2.8 shall be made
solely by Agios; provided, however, that Agios shall not exercise such decision-making authority in any manner that diminishes Celgene’s rights with respect to Marketing Activities pursuant to Section 6.3; 

(iii) except as otherwise directed by Agios and except with respect to Marketing Activities allocated to Celgene pursuant to
Section 6.3, Celgene shall cease to conduct any further Development or Commercialization activities with respect to any Licensed Products and cease to incur any further Development Costs or Commercialization Expenses except as approved by Agios
or as provided in Sections 5.4, 13.3 and 13.4; 

  
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 (iv) Celgene shall provide to Agios a reasonably detailed summary of Development and
Commercialization activities undertaken by Celgene under the Collaboration, including any Clinical Trials committed but not yet completed as of such date; 

(v) Celgene shall undertake, and coordinate with Agios with respect to, any wind-down or transitional activities reasonably necessary to
transfer to Agios all Development, Manufacturing (including all Celgene Manufacturing Responsibilities) and Commercialization responsibility for the Licensed Products throughout the Territory (other than Marketing Activities allocated to Celgene
pursuant to Section 6.3), at Celgene’s sole expense, including those activities referenced in Section 14.3(b)(viii); provided that the Parties shall reasonably cooperate in seeking to minimize the costs of such wind-down
or transitional activities; provided further that (A) if Agios requests that any contracts or agreements that extend beyond the consummation of the Change of Control be terminated, Celgene shall be responsible for all costs
associated with such termination, and (B) if Agios requests that any such contract or agreement remain in effect, Agios shall be responsible for all Development Costs and Commercialization Expenses under such contract or agreement following the
consummation of the Change of Control; 
 (vi) Agios shall have the option to obtain Celgene’s inventory of the Licensed Products and
their active pharmaceutical ingredients at a price equal to their Manufacturing Costs; 
 (vii) in the event Celgene is utilizing a Third
Party manufacturer to Manufacture the Licensed Products or their active pharmaceutical ingredients, to the extent permitted by the terms of such contract, Celgene shall, if requested by Agios, promptly assign to Agios the manufacturing agreements
with such Third Party with respect to such products and ingredients; 
 (viii) Celgene shall transfer, or have transferred, to Agios or its
designee, pursuant to a technology transfer plan to be mutually agreed by the Parties, all Manufacturing Technology Controlled by Celgene or CIS II within Celgene Intellectual Property that is both necessary to Manufacture the Licensed Products or
their active pharmaceutical ingredients as Manufactured by or on behalf of Celgene and its Affiliates, and Celgene shall provide reasonable assistance in connection with the transfer of such Manufacturing Technology to Agios or its designee, all of
which shall be deemed Development Costs; 
 (ix) notwithstanding anything to the contrary in Section 2.8 or otherwise herein, Agios
shall have the right to resolve all disputes within any Committee and final decision making authority on all unresolved matters throughout the US Territory; 

(x) all of Celgene’s rights under Article X (other than Section 10.1) with respect to the Agios Patent Rights, Agios Collaboration
Intellectual Property, and Joint Patents shall terminate, and Celgene shall transition to Agios all of Celgene’s Prosecution and enforcement responsibilities with respect to Agios Patents Rights, Agios Collaboration Patent Rights, Joint
Inventions and Joint Patents, and provide reasonable assistance to Agios and cooperation in connection therewith, including execution of such documents as may be necessary to effect such transition, and Celgene’s rights under Sections 10.2(b)
and 10.2(d) on Prosecution 

  
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matters all terminate notwithstanding anything to the contrary in Article X, provided that Celgene shall retain its step-in rights under Section 10.2(a) and 10.3(d) and shall
be extended comparable step-in rights under Celgene-Controlled Agios Patent Rights as those Agios had under Section 10.2(b) and 10.2(d); and 

(xi) the AGI-23088 ROW Agreement will be affected in a corresponding manner as provided therein. 

(c) Definition. For purposes of this Agreement, “Change of Control” of a Party means any of the following, in a single
transaction or a series of related transactions: (i) the sale or disposition of all or substantially all of the assets of such Party to a Third Party, (ii) the direct or indirect acquisition by a Third Party (other than an employee benefit
plan (or related trust) sponsored or maintained by such Party or any of its Affiliates) of beneficial ownership of more than fifty percent (50%) of the then-outstanding common shares or voting power of such Party, or (iii) the merger or
consolidation of such Party with or into a Third Party, unless, following such merger or consolidation, the stockholders of such Party immediately prior to such merger or consolidation beneficially own directly or indirectly more than fifty percent
(50%) of the then-outstanding common shares or voting power of the entity resulting from such merger or consolidation. 

Section 15.6 Force Majeure. If the performance of any part of this Agreement by a Party is prevented, restricted,
interfered with or delayed by an occurrence beyond the control of such Party (and which did not occur as a result of such Party’s financial condition, negligence or fault), including fire, earthquake, flood, embargo, power shortage or failure,
acts of war or terrorism, insurrection, riot, lockout or other labor disturbance, governmental acts or orders or restrictions, acts of God (for the purposes of this Agreement, a “force majeure event”), such Party shall, upon giving
written notice to the other Party, be excused from such performance to the extent of such prevention, restriction, interference or delay; provided that the affected Party shall use its Commercially Reasonable Efforts to avoid or remove
such causes of non-performance and shall continue performance with the utmost dispatch whenever such causes are removed. 

Section 15.7 Notices. Unless otherwise agreed by the Parties or specified in this Agreement, all notices required or permitted to
be given under this Agreement shall be in writing and shall be sufficient if: (a) personally delivered; (b) sent by registered or certified mail (return receipt requested and postage prepaid); (c) sent by express courier service
providing evidence of receipt and postage prepaid where applicable; or (d) sent by facsimile transmission (receipt verified and a copy promptly sent by another permissible method of providing notice described in clauses (a), (b) or
(c) above), to address for a Party set forth below, or such other address for a Party as may be specified in writing by like notice: 
  

			
	 To Agios:
  

Agios Pharmaceuticals, Inc.
 38 Sidney Street

Cambridge, MA 02139
 Attention: J. Duncan Higgons

Telephone: (617) 649-8634
 Facsimile: (617) 649-8618
	  	 To Celgene:
  

Celgene Corporation
 86 Morris Avenue

Summit, NJ 07901
 Attention: George S. Golumbeski

Telephone: (908) 673-9043
 Facsimile: (908)
673-2769




  
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	 With copies to:
  

WilmerHale LLP
 60 State Street

Boston, MA 02109
 Attention: Steven D. Singer, Esq.

Telephone: (617) 526-6000
 Facsimile: (617) 526-5000

 
 Agios Pharmaceuticals, Inc.

38 Sidney Street
 Cambridge, MA 02139

Attention: Legal Department
 Telephone: (617) 649-8600

Facsimile: (617) 649-8618
	  	 With a copy to:
  

Celgene Corporation
 86 Morris Avenue

Summit, NJ 07901
 Attention: Legal Department

Telephone: (908) 673-9000
 Facsimile: (908) 673-2162



 Any such notices shall be effective upon receipt by the Party to whom it is addressed. 

Section 15.8 Waiver. Except as otherwise expressly provided in this Agreement, any term of this Agreement may be waived only by a
written instrument executed by a duly authorized representative of the Party waiving compliance. The delay or failure of either Party at any time to require performance of any provision of this Agreement shall in no manner affect such Party’s
rights at a later time to thereafter enforce such provision. No waiver by either Party of any condition or term in any one or more instances shall be construed as a further or continuing waiver of such condition or term or of another condition or
term. 
 Section 15.9 Severability. If any provision of this Agreement should be held invalid, illegal or unenforceable in any
jurisdiction, the Parties shall negotiate in good faith a valid, legal and enforceable substitute provision that most nearly reflects the original intent of the Parties and all other provisions of this Agreement shall remain in full force and effect
in such jurisdiction and shall be liberally construed in order to carry out the intentions of the Parties hereto as nearly as may be possible. If the Parties cannot agree upon a substitute provision, the invalid, illegal or unenforceable provision
of this Agreement shall not affect the validity of this Agreement as a whole, unless the invalid, illegal or unenforceable provision is of such essential importance to this Agreement that it is to be reasonably assumed that the Parties would not
have entered into this Agreement without the invalid, illegal or unenforceable provision. 
 Section 15.10 Entire Agreement.
This Agreement (including the Exhibits attached hereto) constitutes the entire agreement between the Parties relating to its subject matter, and supersedes all prior and contemporaneous agreements, representations or understandings, either written
or oral, between the Parties with respect to such subject matter, including the 2010 Agreement solely with respect to AGI-23088. There are no covenants, promises, agreements, warranties, representations, conditions or understandings, either oral or
written, between the Parties other than as set forth herein and therein. 

  
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 Section 15.11 Modification. No modification, amendment or addition to this Agreement,
or any provision hereof, shall be effective unless reduced to writing and signed by a duly authorized representative of each Party. No provision of this Agreement shall be varied, contradicted or explained by any oral agreement, course of dealing or
performance or any other matter not set forth in an agreement in writing and signed by a duly authorized representative of each Party. 

Section 15.12 Independent Contractors; No Intended Third Party Beneficiaries. This Agreement is not intended nor shall be deemed
or construed to create any relationship of employer and employee, agent and principal, partnership, or joint venture between the Parties. Each Party is an independent contractor. Neither Party shall assume, either directly or indirectly, any
liability of or for the other Party. Neither Party shall have any express or implied right or authority to assume or create any obligations on behalf of, or in the name of, the other Party, nor to bind the other Party to any contract, agreement or
undertaking with any Third Party. There are no express or implied third party beneficiaries hereunder, (a) except for the indemnitees identified in Sections 13.1 and 13.2, and (b) except that [**] are intended third party beneficiaries of
certain provisions of this Agreement, as specifically referred to herein. Notwithstanding the provisions of this Section 15.12, the provisions of Section 15.16 shall control for U.S. federal income tax purposes, as applicable. 

Section 15.13 Interpretation; Construction. The captions to the several Articles and Sections of this Agreement are included only
for convenience of reference and shall not in any way affect the construction of, or be taken into consideration in interpreting, this Agreement. In this Agreement, unless the context requires otherwise, (a) the word “including” shall
be deemed to be followed by the phrase “without limitation” or like expression; (b) references to the singular shall include the plural and vice versa; (c) references to masculine, feminine and neuter pronouns and expressions
shall be interchangeable; (d) the words “herein” or “hereunder” relate to this Agreement; (e) “or” is disjunctive but not necessarily exclusive; (f) the word “will” shall be construed to have
the same meaning and effect as the word “shall”; and (g) all references to “dollars” or “$” herein shall mean U.S. Dollars. Each Party represents that it has been represented by legal counsel in connection with
this Agreement and acknowledges that it has participated in the drafting hereof. In interpreting and applying the terms and provisions of this Agreement, the Parties agree that no presumption will apply against the Party which drafted such terms and
provisions. 
 Section 15.14 Performance by Affiliates. To the extent that this Agreement imposes obligations on Affiliates of a
Party, such Party agrees to cause its Affiliates to perform such obligations. 
 Section 15.15 Counterparts. This Agreement may
be executed in two (2) counterparts, each of which shall be deemed an original, and both of which together shall constitute one and the same instrument. 

Section 15.16 Certain U.S. Federal Income Tax Treatment. Pursuant to Section 15.12, this Agreement is not intended nor shall
be deemed or construed to create any relationship of employer and employee, agent and principal, legal partnership, or joint venture between the Parties; provided however, the Parties hereby acknowledge and agree that the Collaboration
shall 

  
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be treated as a partnership for U.S. federal and state income tax purposes only pursuant to Section 7701(a)(2) of the Code and the Treasury Regulations thereunder, and each of Agios and
Celgene shall be treated as partners in such partnership (the “CA 23088 US Partnership”), for all taxable periods that the Collaboration is effective and before the Agios Opt-Out Date. Agios and Celgene agree that each will take no
position inconsistent with partnership tax treatment for U.S. federal and state income tax purposes for such time. For so long as the tax partnership remains in existence, (a) Celgene shall control all tax matters with respect to the CA 23088
US Partnership (including the preparation of returns and making of elections) and shall be the “tax matters partner” of the CA 23088 US Partnership (as that term is defined in Section 6231(a)(7) of the Code), (b) Agios shall
cooperate as reasonably requested by Celgene in furtherance of (a), (c) the CA 23088 US Partnership shall comply with the provisions of Subchapter K of the Code and the Treasury Regulations thereunder, including the requirements of
Section 704 of the Code and the Treasury Regulations thereunder with respect to the maintenance of capital accounts and allocation of items, and (d) each payment made by Celgene in connection with this Agreement (including the initial
payment pursuant to Section 9.1 and each milestone payment pursuant to Section 9.3) shall be reported for U.S. federal income tax purposes so as to maximize the amount deductible to Celgene in respect of any such payment (including as a
result of the allocation of an amortization deduction) to the full extent permitted by the Code. Exhibit I of this Agreement sets for the Parties’ intentions regarding allocations and other tax matters related to the tax partnership.
Exhibit I shall be interpreted in a manner consistent with this Section 15.16. 
 Section 15.17 HSR Clearance; Cooperation.

 (a) HSR Filing. Notwithstanding anything in this Section to the contrary, the Parties shall use Commercially Reasonable Efforts to
promptly obtain any necessary clearance under the HSR Act with respect to the transactions contemplated by this Agreement, including the prompt filing of a copy of this Agreement and each Party’s respective premerger notification and report
forms with the FTC and the DOJ pursuant to the HSR Act, and shall keep each other apprised of the status of any communications with, and any inquiries or requests for additional information from, the FTC and the DOJ and shall comply with any such
inquiry or request; provided, however, that neither Party shall be required to consent to the divestiture or other disposition of any of its assets or assets of its Affiliates or to consent to any other structural or conduct
remedy, and each Party and its Affiliates shall have no obligation to consent, administratively or in court, to any ruling, order or other action of the FTC or DOJ or any Third Party respecting the transactions contemplated by this Agreement. 

(b) Cooperation. The Parties commit to instruct their respective counsel to cooperate with each other and use Commercially Reasonable
Efforts to facilitate and expedite the identification and resolution of any such issues and, consequently, the expiration of the applicable HSR Act waiting period. Each Party’s counsel will undertake (A) to keep each other appropriately
informed of communications from and to personnel of the reviewing antitrust authority, and (B) to confer with each other regarding appropriate contacts with and response to personnel of the FTC or DOJ. Celgene shall be responsible for the
filing fee in connection with any HSR Act filing relating to the transactions contemplated in this Agreement. 
 (c) Definitions. For
purposes of this Section 15.17, the following definitions shall apply: 
 (i) “DOJ” means the United States
Department of Justice. 

  
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 (ii) “FTC” means the United States Federal Trade Commission. 

(iii) “HSR Act” means the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended (15 U.S.C. §18a), and the
rules and regulations promulgated thereunder. 
 [Remainder of page intentionally left blank] 

  
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 IN WITNESS WHEREOF, the Parties have executed this Collaboration and License Agreement as of the
Effective Date. 
  

			
	AGIOS PHARMACEUTICALS, INC.
		
	By:	 	 /s/ David Schenkein

	Name:	 	 David Schenkein

	Title:	 	 CEO

	
	CELGENE CORPORATION
		
	By:	 	 /s/ Thomas Daniel

	Name:	 	 Thomas Daniel

	Title:	 	 President, R&D










 Exhibit A 

AGI-23088 (Also known as AG-881) 

[**] 

  
 A-1 








 Exhibit B 

Agios Patent Rights and Agios Collaboration Patent Rights 

(as of the Effective Date) 
  

									
	 AGIOS DOCKET NO.
	  	 APPLICATION NO.
	  	 FILING DATE
	  	 PUBLICATION NO.
	  	 PATENT NO.

	[**]	  	[**]	  	[**]	  	[**]	  	[**]

 Confidential Materials omitted and filed separately with the Securities and Exchange Commission. A total of two pages were
omitted. [**] 

  
 B-1 








 Exhibit C 

[Exhibit no longer used] 

  
 C-1 








 Exhibit D 

Existing Third Party Agreement 
 [**] 


  
 D-1 








 Exhibit E 

Certain Financial Definitions 

“Accounting Standards” means (a) GAAP (United States Generally Accepted Accounting Principles) or (b) IFRS
(International Financial Reporting Standards), in either case, consistently applied. 
 “Additional Revenue” means the sum
of (a) recoveries pursuant to Section 10.3(f)(ii)(A) of this Agreement, (b) insurance proceeds relating to liabilities previously paid by the Parties and reflected in Commercialization Expenses, and (c) any payments or
income (other than Net Sales) received by a Party or its Affiliates that are attributable to the Licensed Products and relate to the US Territory. 

“Advertising and Market Research Expenses” means those expenses incurred related to: (a) conducting and monitoring
professional and consumer appraisals of the Licensed Products in the Territory, such as market share services (e.g., IMS data), pricing analysis, special research testing and focus groups; and (b) advertising and promotion of the
Licensed Products in the Territory through any means, including (i) television and radio advertisements; (ii) advertisements appearing in journals, newspapers, magazines or other media; (iii) seminars, symposia and conventions;
(iv) packaging design; (v) programs for education of health care professionals; (vi) product samples; (vii) visual aids and other selling materials; (viii) hospital formulary committee presentations; (ix) presentations
to state and other governmental formulary committees; and (x) all media costs associated with product advertising. 
 “Annual
Net Sales” means, with respect to Licensed Products sold after the Agios Opt-Out Date under this Agreement or the AGI-23088 ROW Agreement (as the term “Licensed Products” is defined therein), the aggregate Net Sales of such
Licensed Products by Celgene or its Affiliates or sublicensees in the portion of such Calendar Year following the Agios Opt-Out Date, and in each subsequent Calendar Year during which this Agreement or the AGI-23088 ROW Agreement is in effect. 

“Commercialization Expenses” mean those expenses incurred by either Party (as detailed below) for the purpose of, and
directly and specifically attributable to, the Commercialization of the Licensed Products in the US Territory, and shall consist of the following expenses: (a) Distribution Costs; (b) Health Care Reform Fees; (c) Manufacturing Costs
for commercial supply in the US Territory; (d) Marketing Expenses; (e) Other Commercialization Costs; (f) Patent and Trademark Prosecution and Enforcement Costs incurred in any country of the US Territory from and after the First
Commercial Sale of a Licensed Product in the country; (g) Product Liabilities; (h) Recall Expenses; (i) Regulatory Maintenance Costs; (j) Selling Expenses; and (k) Third Party Patent Costs incurred in a country of the US
Territory from and after the First Commercial Sale of a Licensed Product in the country. 
 Commercialization Expenses shall not include:
(w) expenses related to any Clinical Trial even if incurred after the First Commercial Sale of a Licensed Product in any country of the US Territory; (x) costs that are deductible from Net Sales under the definition thereof; (y) any
losses, damages, fees, costs and other liabilities incurred by a Party as a result of such Party’s 

  
 E-1 








 
negligence, gross negligence, illegal conduct, willful misconduct or breach of such Party’s representations and warranties made hereunder and any such losses, damages, fees, costs and other
liabilities will be treated as the sole and exclusive responsibility of the Party whose actions or omissions gave rise to such losses, damages, fees, costs and other liabilities; or (z) fines, penalties, assessments or other financial sanctions
levied by any governmental authority on either Party. 
 All of such costs shall be as determined from the books and records of the
applicable Party and its Affiliates maintained in accordance with the Accounting Standards. Notwithstanding anything in this definition to the contrary, only those Commercialization Expenses that are contemplated by, and materially consistent with,
the Commercialization Plan and Commercialization Budget for the Licensed Product shall be chargeable as Commercialization Expenses. For purposes of clarity, no general corporate overhead or fixed charges, such as depreciation, shall constitute
Commercialization Expenses (except as otherwise provided under the definition of Manufacturing Costs). 
 “Development
Costs” means the costs and expenses that are actually incurred by or on behalf of a Party and specifically identifiable or specifically allocable to the Development of the Licensed Products or Companion Diagnostics throughout the Territory.
“Development Costs” shall include: 
 (a) the FTE Costs of the relevant Party or its Affiliates with respect to such Development;

 (b) all Out-of-Pocket Costs incurred by the Parties or their Affiliates, including payments made to Third Parties with
respect to such Development, including Phase IV Trial Expenses (except to the extent that such costs have been included in FTE Costs); 

(c) Regulatory Expenses other than Regulatory Maintenance Costs; 

(d) the cost of contract research organizations (CROs); 

(e) Manufacturing Costs for clinical supply, including: 

(i) costs of packaging of drug products and distribution of drug products used in Clinical Trials; 

(ii) expenses incurred to purchase or package comparator drugs; 

(iii) costs and expenses of disposal of clinical samples; and 

(iv) costs and expenses incurred in scaling up Manufacturing activities related to pre-clinical or clinical supply, including formulation
development activities; 
 (f) Manufacturing Scale-Up Costs; and 

(g) Third Party Patent Costs and Patent and Trademark Prosecution and Enforcement Costs incurred in each country of the Territory prior to the
First Commercial Sale of a Licensed Product in the country. 

  
 E-2 








 Development Costs shall not include: (x) any losses, damages, fees, costs and other
liabilities incurred by a Party as a result of such Party’s negligence, gross negligence, illegal conduct, willful misconduct or breach of such Party’s representations and warranties made hereunder and any such losses, damages, fees, costs
and other liabilities will be treated as the sole and exclusive responsibility of the Party whose actions or omissions gave rise to such losses, damages, fees, costs and other liabilities; or (y) fines, penalties, assessments or other financial
sanctions levied by any governmental authority on either Party. 
 All of such costs shall be as determined from the books and records of
the applicable Party and its Affiliates maintained in accordance with the Accounting Standards. Notwithstanding anything in this definition to the contrary, only those Development Costs that are contemplated by, and materially consistent with, the
Development Plan and Development Budget for the Licensed Product shall be chargeable as Development Costs. For purposes of clarity, no general corporate overhead or fixed charges, such as depreciation, shall constitute Development Costs (except as
otherwise provided under the definition of Manufacturing Costs). 
 “Distribution Costs” means Out-of-Pocket Costs and FTE
Costs identifiable to the distribution of the Licensed Products in the US Territory, including customer and wholesaler services, collection of data on sales, order entry, billing, shipping, logistics, warehousing, product insurance, freight not paid
by customers, credit collection and similar activities. 
 “FTE” means a full-time equivalent person year (consisting of a
total of [**] hours per year) of scientific, technical or commercialization work undertaken by a Party’s employees. 
 “FTE
Costs” means, for any period, the FTE Rate multiplied by the number of FTEs in such period. 
 “FTE Rate” means
$[**] per FTE for each FTE devoted to Development and the overall rate as established from time to time by the Finance Working Group pursuant to Section 2.9(b)(vi) for each FTE devoted to Commercialization. On January 1, 2016 and on
January 1st of each subsequent Calendar Year, the foregoing rates shall be increased for the Calendar Year then commencing by the percentage increase, if any, in the Consumer Price Index
(“CPI”) as of December 31 of the then most recently completed Calendar Year with respect to the level of the CPI on December 31, 2014. As used in this definition, Consumer Price Index or CPI means the Consumer Price Index
– Urban Wage Earners and Clerical Workers, US City Average, All Items, 1982-84 = 100, published by the United States Department of Labor, Bureau of Vital Statistics (or its successor equivalent index). 

“Health Care Reform Fees” means Out-of-Pocket Costs representing the annual fee paid to the U.S. Government as defined in the
Patient Protection and Affordable Care Act (“PPACA”) and similar taxes and governmental fees in the United States, in each case to the extent directly attributable to the Licensed Products. If any similar governmental fee is
legislated or rule created in any jurisdiction in the Territory, such fee would be considered Health Care Reform Fees to the extent directly attributable to the Licensed Products. 

  
 E-3 








 “Manufacturing Costs” means, with respect to the Licensed Products, the
reasonable FTE Costs and Out-of-Pocket Costs of a Party or any of its Affiliates or sublicensees incurred in Manufacturing the Licensed Products, excluding Manufacturing Scale-Up Costs, but including: 

(a) to the extent that the Licensed Products are manufactured by a Party or any of its Affiliates or sublicensees, direct material and direct
labor costs, plus manufacturing overhead attributable to the Compound and any Products (including facility start-up costs, all directly incurred manufacturing variances, and a reasonable allocation of related manufacturing administrative and
facilities costs (including depreciation) and a reasonable allocation of the costs of failed batches to be further described in the applicable supply agreement, to be provided for the Licensed Products, but excluding costs associated with excess
capacity), all determined in accordance with the books and records of the applicable Party or its Affiliates or sublicensees maintained in accordance with the Accounting Standards, consistently applied; and 

(b) to the extent that the Licensed Products are manufactured by a Third Party manufacturer, the Out-of-Pocket Costs paid by a Party or any of
its Affiliates or sublicensees to the Third Party for the manufacture, supply, packaging and labeling of the Licensed Products, and any reasonable Out-of-Pocket Costs and direct labor costs actually incurred by such Party or any of its Affiliates or
sublicensees in managing or overseeing the Third Party relationship, determined in accordance with the books and records of the applicable Party or its Affiliates or sublicensees maintained in accordance with the Accounting Standards, consistently
applied. 
 “Manufacturing Scale-Up Costs” means the reasonable FTE Costs and Out-of-Pocket Costs of a Party or any of its
Affiliates or sublicensees incurred in scaling up Manufacturing activities related to the Licensed Products for clinical and commercial supply, including (a) costs for process development work, analytical method optimization, and process
validation, (b) costs for complete technology transfer to a commercial site (including costs for Manufacturing of demonstration batches on a suitable scale), and (c) Regulatory Expenses associated with such Manufacturing activities. 

“Marketing Expenses” mean the sum of Marketing Management Expenses, Advertising and Market Research Expenses and Medical
Education Expenses. 
 “Marketing Management Expenses” mean FTE Costs of the Parties arising from the management of
marketing activities for the Licensed Products in the Field in the US Territory, including management and administration of managed care and national accounts and other activities associated with developing overall sales and marketing strategies;
product-related advertising, market research and public relations; relationship maintenance with opinion leaders, professional societies, contract pricing administrators, and market information systems; education programs for health care
professionals; governmental affairs activities for reimbursement, formulary acceptance; and other activities directly related to the marketing and/or promotion of a Licensed Product in the Territory; provided, that, in each case, such
costs may be allocated to the Licensed Product on a percent of sales or other basis consistently applied within and across a Party’s operating units; provided, further, that such allocation is made no less favorable to the
Licensed Product than to the internal allocation to such Party’s other products. 

  
 E-4 








 “Medical Education Expenses” means all Out-of-Pocket Costs specifically incurred
to educate health care professionals licensed to practice in the US Territory with respect to a Licensed Product in the US Territory through any means not covered in the definition of “Advertising and Marketing Research Expenses”, but
including articles appearing in journals, newspapers, magazines or other media; seminars, scientific exhibits, and conventions; and symposia, advisory boards and opinion leader development activities; and education grant programs. 

“Net Sales” means, with respect to any Licensed Product, gross amounts invoiced by the Parties, their respective Affiliates
or sublicensees to Third Parties (that are not sublicensees) for the sale or other commercial disposition of such Licensed Product anywhere within the US Territory, including sales to wholesale distributors, less deductions from such amounts
calculated in accordance with the Accounting Standards so as to arrive at “net sales” under the Accounting Standards, and further reduced by write-offs of accounts receivables or increased for collection of accounts that were previously
written off. 
 Net Sales, and any and all set-offs against gross amounts invoiced, shall be determined from books and records maintained in
accordance with the Accounting Standards, consistently applied throughout the organization and across all products of the entity whose sales of any Product are giving rise to Net Sales. Sales or other commercial dispositions of Licensed Products
between a Party and its Affiliates and its sublicensees, and Licensed Products provided to Third Parties without charge, in connection with research and development, clinical trials, compassionate use, humanitarian and charitable donations, or
indigent programs or for use as samples shall be excluded from the computation of Net Sales, and no payments will be payable on such sales or such other commercial dispositions, except where such an Affiliate or sublicensee is an end user of the
Licensed Product. 
 If a Licensed Product is sold or otherwise commercially disposed of for consideration other than cash or in a
transaction that is not at arm’s length between the buyer and the seller, then the gross amount to be included in the calculation of Net Sales shall be the amount that would have been invoiced had the transaction been conducted at arm’s
length and for cash. Such amount that would have been invoiced shall be determined, wherever possible, by reference to the average selling price of the relevant Product in arm’s length transactions in the relevant country. 

In the event of an Agios Opt-Out Date, then, notwithstanding the foregoing, in the event a Licensed Product is sold as a Combination Product
following the Agios Opt-Out Date, then Net Sales shall be calculated by multiplying the Net Sales of the Combination Product by the fraction A/(A+B), where A is the gross invoice price of the Licensed Product if sold separately in a country and B is
the gross invoice price of the other product(s) included in the Combination Product if sold separately in such country. If no such separate sales are made by the relevant Party, its Affiliates or sublicensees in a country, Net Sales of the
Combination Product shall be calculated in a manner to be negotiated and agreed upon by the Parties, reasonably and in good faith, prior to any sale of such Combination Product, which shall be based upon the relative value of the active components
of such Combination Product. 

  
 E-5 








 As used in this definition, “Combination Product” means any product that
comprises a Licensed Product sold in conjunction with another active ingredient so as to be a combination product (whether packaged together or in the same therapeutic formulation). Pharmaceutical dosage form vehicles, adjuvants and excipients shall
be deemed not to be “active ingredients.” 
 “Other Commercialization Costs” means any Out-of-Pocket Costs and
FTE Costs approved by the JCC and included in the Commercialization Budget and Commercialization Plan that is not otherwise included in any other Commercialization Expense category. It is understood that Other Commercialization Costs shall not
include costs associated with Development activities. 
 “Out-of-Pocket Costs” means, with respect to certain activities
hereunder, direct expenses paid or payable by either Party or its Affiliates to Third Parties (other than employees of such Party or its Affiliates) that are specifically identifiable and incurred to conduct such activities for the Collaboration
hereunder and have been recorded in accordance with the Accounting Standards. 
 “Patent and Trademark Prosecution and Enforcement
Costs” means (a) costs incurred pursuant to Sections 10.2(e), 10.3(e) and 10.4, and (b) costs incurred in connection with the selection, protection, utilization and defense of Product Trademarks relating to the Licensed Products.

 “Phase IV Trial Expenses” means all Out-of-Pocket Costs incurred for the US Territory related to a Phase IV Study for
any Licensed Product in the US Territory, including expenses arising from: (a) the activities related to the performance of the Phase IV Trial; (b) Manufacturing Costs for Licensed Product used in connection with such Phase IV Study;
(c) preparation, filing, and maintenance of related Regulatory Documentation; and (d) any Product Liabilities relating to a Licensed Product being used in the course of such Phase IV Study; provided, however, any losses,
damages, fees, costs and other liabilities, including any Product Liabilities, that are the result of a Party’s negligence, gross negligence, illegal conduct, willful misconduct or breach of such Party’s representations or warranties, are
expressly excluded from the definition of Phase IV Trial Expenses, and shall be treated as the sole and exclusive responsibility of the Party whose actions or omissions gave rise to such losses, damages, fees, costs and other liabilities. 

“Product Liabilities” means all losses, damages, fees, costs and other liabilities incurred by a Party, its Affiliate or its
sublicensee and resulting from or relating to the use of a Licensed Product in a human (including clinical trials and/or Commercialization) in the US Territory incurred after the Effective Date. For the avoidance of doubt, Product Liabilities
include reasonable attorneys’ and experts’ fees and costs relating to any claim or potential claim against a Party, its Affiliate, or its sublicensee and all losses, damages, fees and costs associated therewith. Product Liabilities shall
not include liabilities associated with recalls and/or the voluntary or involuntary withdrawal of the Licensed Product. 

  
 E-6 








 “Recall Expenses” means Out-of-Pocket Costs and FTE Costs directly associated
with notification, retrieval and return of Licensed Products, distribution of such returned Licensed Products, replacement Licensed Products and distribution of the replacement Licensed Products, in each case in the US Territory and that are
incurred with respect to a recall conducted in accordance with Section 5.4 of this Agreement. 
 “Regulatory Expenses”
means, with respect to the Licensed Products, all Out-of-Pocket Costs incurred by or on behalf of a Party in connection with the preparation and filing of regulatory submissions for the Licensed Products and obtaining of Regulatory Approvals and any
applicable governmental price and reimbursement approvals. 
 “Regulatory Maintenance Costs” means Out-of-Pocket Costs and
FTE Costs for maintenance fees relating to Regulatory Approvals for the Licensed Products in the US Territory, and personnel engaged in the filing and maintenance of Regulatory Approvals. 

“Selling Expenses” means (a) the FTE Costs incurred by the Parties in performance of details or Out-of-Pocket Costs
incurred by the Parties for the performance of details by a qualified contract sales force in the US Territory; where such FTE Costs shall be calculated on the basis of a fixed rate per detail, which shall be approved by the JSC prior to the First
Commercial Sale in the US Territory, and (b) Out-of-Pocket Costs and FTE Costs directly attributable to selling the Licensed Products in the US Territory, including sales managers, exhibits at shows or conventions including samples, charges for
space, sales aids and brochures, sales meetings, specialty sales forces, call reporting and Third Party monitoring/tracking services. 

“Third Party Patent Costs” means Out-of-Pocket Costs paid to Third Parties pursuant to Section 9.6(b) of this Agreement.

 “US Territory Profit or Loss” means the profits or losses resulting from the Commercialization of the Licensed Products
in the Territory and which shall be equal to (a) the sum of (i) Net Sales of Licensed Products in the Territory, plus (ii) Additional Revenue, less (b) Commercialization Expenses for such Licensed Products. As used herein,
“US Territory Profit” refers to a Calendar Quarter or Calendar Year in which a profit exists, and “US Territory Loss” refers to a Calendar Quarter or Calendar Year in which a loss exists. 

  
 E-7 








 Exhibit F 

Countries for Filing Agios Patent Rights and Collaboration Patent Rights 

[**] 

  
 F-1 








 Exhibit G 

Press Release 
  





 
 Agios Pharmaceuticals Selects Third Novel IDH Mutant Inhibitor, AG-881, for Clinical Development 

 

	 	•	 	Brain-penetrant, pan-IDH mutant inhibitor broadens pipeline for treatment of patients with IDH mutant positive cancers 

  

	 	•	 	New worldwide development and profit share collaboration for AG-881 entered into by Agios and Celgene 

  

	 	•	 	Expect to initiate clinical development for AG-881 in second quarter 2015 

 CAMBRIDGE, Mass.,
April 28, 2015 — Agios Pharmaceuticals, Inc. (NASDAQ: AGIO), a leader in the fields of cancer metabolism and rare genetic disorders of metabolism, today announced that it plans to advance into clinical development AG-881, a small
molecule that has shown in preclinical studies to fully penetrate the blood brain barrier and inhibit isocitrate dehydrogenase-1 (IDH1) and IDH2 mutant cancer cells, in collaboration with its cancer metabolism partner Celgene Corporation. The
companies have entered into a new joint worldwide development and profit share collaboration for AG-881, and plan to initiate clinical development of AG-881 in the second quarter of 2015. AG-881 will be the third IDH mutant inhibitor discovered by
Agios to enter clinical development. 
 “The addition of our third IDH mutant inhibitor to our growing pipeline is an exciting milestone for
Agios and underscores our goals to lead the scientific understanding of cancer metabolism and help as many patients as possible with an IDH mutant positive cancer,” said David Schenkein, M.D., chief executive officer of Agios. “AG-221 and
AG-120 remain our lead medicines in clinical development and are advancing rapidly. We believe the addition of AG-881 given its unique profile provides added flexibility to our portfolio of IDH inhibitors. Based on our preclinical findings, it has
the potential to support our ongoing development effort to provide treatment options to patients with glioma, and it represents a possible second-generation molecule for both AG-221 and AG-120 in IDH mutant tumors. We look forward to generating data
for AG-881 to inform our future development plans.” 

  
 G-1 








 Under the terms of the new AG-881 collaboration, Agios will receive an initial payment of $10 million in the
second quarter of 2015 and is eligible to receive regulatory milestone payments of up to $70 million. Agios and Celgene will jointly collaborate on the worldwide development program for AG-881, sharing development costs 50/50 worldwide. The two
companies have agreed to share any worldwide profits 50/50, with Celgene booking worldwide commercial sales. Agios would lead commercialization in the U.S. with both companies sharing equally in field-based commercial activities, and Celgene would
lead commercialization ex-U.S. with Agios providing one third of field-based commercial activities in the major E.U. markets. 
 Summary of Agios and
Celgene Collaboration on IDH Mutant Inhibitors 
 Agios and Celgene entered a global, strategic collaboration in April 2010 and, to date, three potential
new distinct investigational medicines have emerged – the IDH2 mutant inhibitor, AG-221; the IDH1 mutant inhibitor, AG-120; and the pan-IDH mutant inhibitor, AG-881, which as described above is now part of a new collaboration between the
companies. These three investigational medicines aim to improve the treatment outcomes for patients whose cancers carry these IDH mutations, including difficult to treat acute myelogenous leukemia and glioma, a type of aggressive brain tumor with
poor prognosis. Each of these investigational medicines carries different financial terms and rights under the collaboration, including: 
  

	•	 	AG-221: Celgene has worldwide development and commercialization rights for AG-221. Agios is eligible for up to $120 million in milestone payments and royalties on any net sales.  


 

	•	 	AG-120: Agios retains U.S. development and commercialization rights, while Celgene has development and commercialization rights outside the U.S. Agios is eligible to receive royalties on any net sales
outside the U.S. and up to $120 million in milestone payments. Celgene is eligible to receive royalties on any net sales in the U.S. 

  

	•	 	AG-881: Joint worldwide development and 50/50 profit share agreement. Agios is eligible to receive regulatory milestone payments up to $70 million.  


About Agios Pharmaceuticals, Inc. 
 Agios Pharmaceuticals
is focused on discovering and developing novel investigational medicines to treat cancer and rare genetic disorders of metabolism through scientific leadership in the field of cellular metabolism. In addition to an active research and discovery
pipeline across both therapeutic areas, Agios has multiple first-in-class investigational medicines in clinical and/or preclinical development. All Agios programs focus on genetically identified patient populations, leveraging our knowledge of
metabolism, biology and genomics. For more information, please visit the company’s website at agios.com. 

  
 G-2 








 Cautionary Note Regarding Forward-Looking Statements 

This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking
statements include those regarding the potential benefits of, and plans relating to, the collaboration with Celgene; the potential benefits of AG-221, AG-120 and AG-881; and Agios’ plans to generate data from AG-881 to inform its future
development plans; and the benefit of Agios’ strategic plans and focus. The words “anticipate,” “believe,” “estimate,” “expect,” “goal,” “intend,” “may,” “plan,”
“possible,” “potential,” “predict,” “project,” “could,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements
contain these identifying words. Such statements are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from Agios’ current expectations and beliefs. For example, there
can be no guarantee that AG-881 or any other product candidate Agios is developing will successfully commence or complete necessary preclinical and clinical development phases, or that development of any of Agios’ product candidates will
successfully continue. There can be no guarantee that any positive developments in Agios’ business will result in stock price appreciation. Management’s expectations and, therefore, any forward-looking statements in this press release
could also be affected by risks and uncertainties relating to a number of other important factors, including: Agios’ results of clinical trials and preclinical studies, including subsequent analysis of existing data and new data received from
ongoing and future studies; the content and timing of decisions made by the U.S. FDA and other regulatory authorities, investigational review boards at clinical trial sites and publication review bodies; Agios’ ability to obtain and maintain
requisite regulatory approvals and to enroll patients in its planned clinical trials; unplanned cash requirements and expenditures; competitive factors; Agios’ ability to obtain, maintain and enforce patent and other intellectual property
protection for any product candidates it is developing; Agios’ ability to maintain key collaborations; and general economic and market conditions. These and other risks are described in greater detail under the caption “Risk Factors”
included in Agios’ Annual Report on Form 10-K for the year ended December 31, 2014, and other filings that Agios may make with the Securities and Exchange Commission in the future. Any forward-looking statements contained in this press
release speak only as of the date hereof, and Agios expressly disclaims any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. 

### 
 Contact: 

Agios Pharmaceuticals, Inc. 
 Lora Pike, 617-649-8608 

Senior Director, Investor Relations and Public Relations 

lora.pike@agios.com 

  
 G-3 








 Exhibit H 

Initial JSC, JDC and JPC Appointments 
  

					
	 Joint Steering Committee (JSC)

 

	 Position
	  	 Celgene Appointee
	  	 Agios Appointee

	Initial Chairperson	  	[**]	  	[**]
			
	JSC Member	  	[**]	  	[**]
			
	JSC Member	  	[**]	  	[**]
			
	JSC Member	  	[**]	  	[**]

  

					
	 Joint Development Committee (JDC)

 

	 Position
	  	 Celgene Appointee
	  	 Agios Appointee

	Initial Chairperson	  	[**]	  	[**]
			
	JDC Member	  	[**]	  	[**]
			
	JDC Member	  	[**]	  	[**]
			
	JDC Member	  	[**]	  	[**]

  

					
	 Joint Patent Committee (JPC)

 

	 Position
	  	 Celgene Appointee
	  	 Agios Appointee

	Initial Chairperson	  	[**]	  	[**]
			
	JPC Member	  	[**]	  	[**]
			
	JPC Member	  	[**]	  	[**]


  
 H-1 








 Exhibit I 

Partnership Tax Matters 

(See attached.) 

  
 I-1