EXHIBIT 31(b)

                            CERTIFICATION PURSUANT TO
                  SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Barry Weiner, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Enzo Biochem, Inc.

2. Based on my knowledge, this report does not contain any untrue statement of a
   material fact or omit to state a material fact necessary to make the
   statements made, in light of the circumstances under which such statements
   were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial
   information included in this report, fairly present in all material respects
   the financial condition, results of operations and cash flows of the Company
   as of, and for, the periods presented in this report;

4. The Company's other certifying officer and I are responsible for establishing
   and maintaining disclosure controls and procedures (as defined in Exchange
   Act Rules 13a - 15(e) and 15d - 15(e)) and internal control over financial
   reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the
   Company and have:

(a) Designed such disclosure controls and procedures, or caused such disclosure
    controls and procedures to be designed under our supervision, to ensure that
    material information relating to the Company, including its consolidated
    subsidiaries, is made known to us by others within those entities,
    particularly during the period in which this report is being prepared;

(b) Designed such internal control over financial reporting, or caused such
    internal control over financial reporting to be designed under our
    supervision, to provide reasonable assurance regarding the reliability of
    financial reporting and the preparation of financial statements for external
    purposes in accordance with generally accepted accounting principles;

(c) Evaluated the effectiveness of the Company's disclosure controls and
    procedures and presented in this report our conclusions about the
    effectiveness of the disclosure controls and procedures, as of the end of
    the period covered by this report based on such evaluation; and

(d) Disclosed in this report any change in the Company's internal control over
    financial reporting that occurred during the Company's most recent fiscal
    quarter that has materially affected, or is reasonably likely to materially
    affect, the Company's internal control over financial reporting; and

5. The Company's other certifying officer and I have disclosed, based on our
   most recent evaluation of internal control over financial reporting, to the
   Company's auditors and the audit committee of the Company's board of
   directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or
    operation of internal control over financial reporting which are reasonably
    likely to adversely affect the Company's ability to record, process,
    summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other
    employees who have a significant role in the Company's internal control over
    financial reporting.

Date:  June 11, 2007                            By: /s/ Barry Weiner
                                                    ----------------
                                                Barry Weiner
                                                Chief Financial Officer