EXHIBIT 31.1

CERTIFICATION PURSUANT TOSECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Elazar Rabbani, Ph.D., certify that:

|1. | I have reviewed this quarterly report on Form 10-Q of Enzo Biochem, Inc (the “registrant”).                                                                                                                                                                                                                                             
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|2. | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which
such statements were made, not misleading with respect to the period covered by this report;                              
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|3. | Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows
of the registrant as of, and for, the periods presented in this report;                                                 
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|4. | The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a – 15(e) and 15d –
15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
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|   | (c)                                                                                                                                                                                                                                                                                                                                     
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|   | (d)                                                                                                                                                                                                                                                                                                                                     
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|5. | The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit
committee of the registrant’s board of directors (or persons performing the equivalent functions):                                         
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|   | (b)                                                                                                                                                                                                                                                                                                                                     
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Date: June 9, 2008


By: /s/
        Elazar Rabbani, Ph.D.  Elazar Rabbani, Ph.D.  Chief Executive Officer




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