NANOSIZERTM

AUTO

The Future of 

Liposome Technology

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NanoSizer 

Extruder

Syringe 1

Syringe 2

Control Base

Control Screen

Emergency Button

ON/OFF 

Button

The NanoSizerTM AUTO is a fully automated liposome extruder with temperature 

control capability. This device utilizes the NanoSizerTM MINI with two syringes 

and needles. You will always work with a completely clean and consistent 

system every time. NanoSizerTM AUTO has a fully electrical system and works 

with 120V powerline. It extrudes by moving the extrusion blocks up and down by 

constant speed after placing the extruder and two syringes into the device.

Motor Type Schneider Electric

Power 120 V Power

Maintenance No Maintenance Required

Temperature Range Room Temperature - 65

# Of Passes Range Up To 999 Passes

Size 28” X 24” 

Weight 48lb

Syringe Size 1ml 

Extruder NanosizerTM MINI of Your Pore Size

Control Programmable Logic Controller

Monitor Touch Screen Unitronic

Extrusion Tower

NanoSizer 

Extrusion 

Block

NanoSizerTM AUTO I

1 2

NanoSizerTM AUTO 1 NanoSizerTM AUTO 10

System Automated Liposome 

Extrusion

Pore Size 

Available

Extrusion 

Flow Rate

Tempurature

Control

50nm – 10000nm

Syringe Size 1mL 1mL, 3mL, 6mL, 10mL

50nm – 10000nm

0.1mL – 10mL/min 0.1mL – 10mL/min

Up to 95 ̊C Up to 95 ̊C

Automated Liposome 

Extrusion

Overview System Specifications

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Getting Started

Setting Up

The Future of Liposome Technology

NanoSizerTM AUTO 

Press to Begin

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Begin Extrusion You Can Start and Stop Extrusion Using This Button

Extrusion Status Indicates the Status: Extruding or Ready

Move Up / 

Move Down

Moving the Extrusion Block Up for Placing or Taking Out 

the Syringes (Only Works In “Ready” Status)

Set # Of Passes Before Starting Extrusion, The Number of Passes Can 

Be Set Up (31 Passes Recommended), 

# Of Passes Made Live Indicator of Number of Passes Completed

Progress Bar Visual Bar and Percentage Progressed Process

Measured 

Temperature Live Indicator of Current Temperature of Extrusion Block

Set Point 

Temperature

The Temperature of The Block May Be Set Before or 

During the Extrusion Process

Start/Stop Heating The Temperature Turns On or Off by this Button

Speed

The Speed Changes to Slow or Fast, using this 

button. Slow speed is recommended for most 

applications.

Begin 

Extrusion

READY

Move

Up

Move

Down

Set # of Passes

Settings

99999

Slow

# of Passes Made

99999

99999%

Tempurature

Temp. (C) Set Point

Start Heating

Speed

99999.9 99999.9

2. After the black page the start-up page comes up with T&T Scientific Logo.

3. Press any key to proceed to the main screen.

1. Press the blue button to turn on the NanoSizerTM AUTO

1. First place the extruder into the extrusion block.

2. Open two syringes and needles and tighten the needles into the syringes very 

firmly.

3. Place an empty syringe to the bottom slot of extruder block.

4. Draw the solution into the second syringe (up to 1mL).

c Turn the end of the syringe barrel to fix it into the block.

b Make sure to fully insert the needle into the extruder.

Move the block up, using the “Move Up” Button on the screen, if a space for 

placing the syringes, needed.

a

a Move the block down to provide space for the second syringe.

b Make sure to fully insert the needle into the extruder.

c Turn the end of the syringe barrel to fix it into the block.

3 4

Main Screen Indicators
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Slow

Speed

Fast

Speed

Temperature

Temp (C) Set Point

26.2 ̊ 55.0 ̊

Start Heating

Temperature

Temp (C) Set Point

55.0 ̊ 55.0 ̊

STOP Heating

2. Select the desired the extrusion speed. This feature can be modified 

during the extrusion process as well. The constant default speed of slow is 

recommended.

1 2 3

4 5 6

7 8 9

+/- 0 .

Esc

Del

Set # of Passes

31

# of Passes Made

48%

15

5 6

1. Press on the set temperature if higher room temperature needed for extrusion.

• Set Point (SP): Desired Temperature

• Set # of passes (for extrusion)

• # of Passes Made (i.e., to reset/adjust # of Passes Made)

c Press “Start Heating”. 

b Press the enter button to select the desired temperature.

a Press your desired extrusion temperature.

d Wait until the temperature reaches to the desired temperature.

e The heating can be stopped by pressing “STOP Heating” Button.

a Select the desired number of passes

b Press Enter

3. Press the button under “# of passes”

c The number of passes made during the extrusion can be seen in “# Passes 

Made”.

4. Press start extrusion

– Speed will change after completing the current pass.

– Default speed of extrusion is slow which is recommended speed.

– The speed can be also changed during the runs.

5. After the extrusion ended, take the extruded syringe out then withdraw it to 

the desired vial.

6. Dispose the extruder and syringes.

c You can change the speed by pressing on the button under the “Speed”.

b After that the extrusion speeds up to your desired speed (slow or fast).

a The first two passes are slow for calibration purposes.

Protocol of Use
NOTE:

– In a case of emergency, you can completely shut down the device electricity using the red 

button on the right side of the device

– “Move Up” and “Move Down” buttons are inactive during the extrusion process.

– You can stop extrusion any time during the extrusion process, it will stop after you pressing stop 

extrusion button. 

On-Site 

Delivery

1-Year Full 

Warranty

Training

Consistent

Easy

Controlled

Fully 

Automatic 

Extrusion 

Systems

Temperature 

Control

Flow Rate 

and Speed 

Control

Controlled 

Number of 

Passes

Force and 

Pressure 

Measurement

Touch

Screen 

Controller