Federal Register / Vol. 79, No. 238 / Thursday, December 11, 2014 / Notices 73603 

Time: 8:00 a.m. to 6:00 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: One Washington Circle One 

Washington Circle NW., Washington, DC 

20037. 

Contact Person: Raul A. Saavedra, Ph.D., 

Scientific Review Officer, Scientific Review 

Branch, Division of Extramural Research, 

NINDS/NIH/DHHS/Neuroscience Center, 

6001 Executive Boulevard, Suite 3208, MSC 

9529, Bethesda, MD 20892–9529, 301–496– 

9223, saavedrr@ninds.nih.gov. 

Name of Committee: National Institute of 

Neurological Disorders and Stroke Initial 

Review Group; Neurological Sciences and 

Disorders A. 

Date: March 2–3, 2015. 

Time: 8:00 a.m. to 6:00 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: The Fairmont Olympic Hotel, 411 

University Street, Seattle, WA 98101. 

Contact Person: Natalia Strunnikova, 

Ph.D., Scientific Review Officer, Scientific 

Review Branch, Division of Extramural 

Research, NINDS/NIH/DHHS/Neuroscience 

Center, 6001 Executive Boulevard, Suite 

3208, MSC 9529, Bethesda, MD 20892–9529, 

301–402–0288, natalia.strunnikova@nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.853, Clinical Research 

Related to Neurological Disorders; 93.854, 

Biological Basis Research in the 

Neurosciences, National Institutes of Health, 

HHS) 

Dated: December 5, 2014. 

Carolyn Baum, 

Program Analyst, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2014–29021 Filed 12–10–14; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Interagency Coordinating Committee 

on the Validation of Alternative 

Methods Communities of Practice 

Webinar on Reverse Toxicokinetics; 

Notice of Public Webinar and 

Registration Information 

SUMMARY: The Interagency Coordinating 

Committee on the Validation of 

Alternative Methods (ICCVAM) 

announces a public webinar ‘‘Reverse 

Toxicokinetics: Using In Vitro Data to 

Estimate Exposures that Could Be 

Associated with Adverse Effects In 

Vivo.’’ The webinar is organized on 

behalf of ICCVAM by the National 

Toxicology Program Interagency Center 

for the Evaluation Alternative 

Toxicological Methods (NICEATM) and 

hosted by the Environmental Protection 

Agency’s National Center for 

Computational Toxicology (NCCT). 

Interested persons may participate via 

Adobe® ConnectTM. Time is allotted for 

questions from participants. 

DATES: Webinar: January 27, 2015, 1:00 

p.m. to approximately 2:30 p.m. Eastern 

Standard Time (EST). 

Registration for Webinar: December 3, 

2014, until 2:30 p.m. January 27, 2015. 

ADDRESSES: Webinar Web page: http://

ntp.niehs.nih.gov/go/ivive-webinar. 

FOR FURTHER INFORMATION CONTACT: Dr. 

Warren S. Casey, Director, NICEATM; 

email: warren.casey@nih.gov; telephone: 

(919) 316–4729. 

SUPPLEMENTARY INFORMATION: 

Background: ICCVAM promotes the 

development and validation of toxicity 

testing methods that protect human 

health and the environment while 

replacing, reducing, or refining animal 

use. ICCVAM also provides guidance to 

test method developers and facilitates 

collaborations that promote the 

development of new test methods. To 

address these goals, ICCVAM will hold 

the communities of practice webinar 

‘‘Reverse Toxicokinetics: Using In Vitro 

Data to Estimate Exposures that Could 

Be Associated with Adverse Effects In 

Vivo.’’ 

Many commercial and environmental 

chemicals lack toxicity data necessary 

for users and risk assessors to make 

fully informed decisions about potential 

health effects. Generating these data 

using high throughput in vitro cell- or 

biochemical-based tests would be faster 

and less expensive than testing in 

animals; tests that use human cells or 

cellular components would also 

potentially be more relevant to human 

health. However, correlating test 

chemical concentrations that produce 

effects in vitro to exposure levels that 

cause toxicity in vivo is complicated, 

since factors that can significantly 

influence toxicity in vivo (such as 

plasma protein binding and metabolic 

clearance) are often not replicated in in 

vitro assays. Mathematical models 

known as reverse toxicokinetic models 

provide a framework for making these 

correlations. Reverse toxicokinetic 

models provide an estimate of the 

exposure level that would result in a 

blood concentration equal to a chemical 

concentration causing an in vitro 

adverse outcome. 

The ICCVAM webinar will feature 

presentations by two experts in the 

development and application of reverse 

toxicokinetic models to high throughput 

screening data: John Wambaugh, Ph.D., 

physical scientist at NCCT, and Barbara 

Wetmore, Ph.D., senior research 

investigator at the Hamner Institutes for 

Health Sciences. Their presentations 

will provide an overview of the 

development of reverse toxicokinetic 

models and discuss the consideration of 

population variability and sensitive 

subpopulations in the use of these 

models. 

Webinar and Registration: This 

webinar is open to the public with time 

scheduled following each presentation 

for questions by participants. 

Registration for the webinar is required 

and is open from December 3, 2014, 

through 2:30 p.m. on January 27, 2015. 

A link to registration is available at 

http://ntp.niehs.nih.gov/go/ivivewebinar. Registrants will receive 

instructions on how to access and 

participate in the webinar in the email 

confirming their registration. 

The preliminary agenda is available at 

http://ntp.niehs.nih.gov/go/ivivewebinar. Interested individuals are 

encouraged to visit this Web page to 

stay abreast of the most current webinar 

information. 

Individuals with disabilities who 

need accommodation to participate in 

this event should contact Ms. LaCresha 

Styles at phone: (919) 541–3282 or 

email: styles.lacresha@epa.gov. TTY 

users should contact the Federal TTY 

Relay Service at (800) 877–8339. 

Requests should be made at least five 

business days in advance of the event. 

Background Information on ICCVAM 

and NICEATM: ICCVAM is an 

interagency committee composed of 

representatives from 15 federal 

regulatory and research agencies that 

require, use, generate, or disseminate 

toxicological and safety testing 

information. The ICCVAM 

Authorization Act of 2000 (42 U.S.C. 

285l–3) establishes ICCVAM as a 

permanent interagency committee of the 

National Institute of Environmental 

Health Sciences and provides the 

authority for ICCVAM’s involvement in 

activities relevant to the development of 

new and revised toxicological tests. 

ICCVAM conducts technical 

evaluations of new, revised, and 

alternative test methods and integrated 

testing strategies with regulatory 

applicability and promotes the scientific 

validation and regulatory acceptance of 

test methods that both more accurately 

assess the safety and hazards of 

chemicals and products and replace, 

reduce, or refine (enhance animal wellbeing and lessen or avoid pain and 

distress) animal use. ICCVAM acts to 

ensure that new and revised test 

methods are validated to meet the needs 

of federal agencies, to increase the 

efficiency and effectiveness of federal 

agency test method review, and to 

optimize utilization of scientific 

expertise outside the federal 

government. Additional information 

mstockstill on DSK4VPTVN1PROD with NOTICES

73604 Federal Register / Vol. 79, No. 238 / Thursday, December 11, 2014 / Notices 

about ICCVAM can be found at http:// 

ntp.niehs.nih.gov/go/iccvam. 

NICEATM administers ICCVAM, 

provides scientific and operational 

support for ICCVAM activities, and 

conducts independent validation 

studies to assess the usefulness and 

limitations of new, revised, and 

alternative test methods and strategies. 

NICEATM and ICCVAM work 

collaboratively to evaluate new and 

improved test methods and strategies 

applicable to the needs of U.S. federal 

agencies. NICEATM and ICCVAM 

welcome the public nomination of new, 

revised, and alternative test methods 

and strategies for validation studies and 

technical evaluations. Additional 

information about NICEATM can be 

found at http://ntp.niehs.nih.gov/go/

niceatm. 

Dated: December 5, 2014. 

John R. Bucher, 

Associate Director, National Toxicology 

Program. 

[FR Doc. 2014–29018 Filed 12–10–14; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HOMELAND 

SECURITY 

Federal Emergency Management 

Agency 

[Docket ID: FEMA–2014–0034; OMB No. 

1660–0040] 

Agency Information Collection 

Activities: Proposed Collection; 

Comment Request; Standard Flood 

Hazard Determination Form 

AGENCY: Federal Emergency 

Management Agency, DHS. 

ACTION: Notice. 

SUMMARY: The Federal Emergency 

Management Agency, as part of its 

continuing effort to reduce paperwork 

and respondent burden, invites the 

general public and other Federal 

agencies to take this opportunity to 

comment on a revision of a currently 

approved information collection. In 

accordance with the Paperwork 

Reduction Act of 1995, this notice seeks 

comments concerning the renewal of the 

Standard Flood Hazard Determination 

Form which is used by federally 

regulated lending institutions to 

determine if a structure is located 

within an identified Special Flood 

Hazard Area (SFHA) and whether flood 

insurance is available. 

DATES: Comments must be submitted on 

or before February 9, 2015. 

ADDRESSES: To avoid duplicate 

submissions to the docket, please use 

only one of the following means to 

submit comments: 

(1) Online. Submit comments at 

www.regulations.gov under Docket ID 

FEMA–2013–0034. Follow the 

instructions for submitting comments. 

(2) Mail. Submit written comments to 

Docket Manager, Office of Chief 

Counsel, DHS/FEMA, 500 C Street SW., 

Room 8NE, Washington, DC 20472– 

3100. 

(3) Facsimile. Submit comments to 

(703) 483–2999. 

All submissions received must 

include the agency name and Docket ID. 

Regardless of the method used for 

submitting comments or material, all 

submissions will be posted, without 

change, to the Federal eRulemaking 

Portal at http://www.regulations.gov, 

and will include any personal 

information you provide. Therefore, 

submitting this information makes it 

public. You may wish to read the 

Privacy Act notice that is available via 

the link in the footer of 

www.regulations.gov. 

FOR FURTHER INFORMATION CONTACT: 

Susan Bernstein, Program Specialist, 

FEMA, Federal Insurance and 

Mitigation Administration (FIMA), 202– 

212–2113 for additional information. 

You may contact the Records 

Management Division for copies of the 

proposed collection of information at 

facsimile number (202) 212–4701 or 

email address: FEMA-InformationCollections-Management@fema.dhs.gov. 

SUPPLEMENTARY INFORMATION: On 

September 23, 1994, Section 303(a) of 

the Riegle Community Development and 

Regulatory Improvement Act of 1994 

was signed into law. Section 303(a) of 

this Act requires the Federal bank and 

thrift regulatory agencies to conduct a 

systematic review of their regulation 

and written policies in order to improve 

efficiency, reduce unnecessary costs, 

and eliminate inconsistencies and 

outmoded and duplicative 

requirements. Title V of this Act is the 

National Flood Insurance Reform Act 

(NFIRA). Section 528 of the NFIRA 

requires that FEMA develop a standard 

hazard determination form for recording 

the determination of whether a structure 

is located within an identified Special 

Flood Hazard Area (SFHA) and whether 

flood insurance is available. Section 528 

of the NFIRA also requires the use of 

this form by regulated lending 

institutions, federal agency lenders, the 

Federal National Mortgage Association, 

the Federal Home Loan Mortgage 

Corporation, and the Government 

National Mortgage Association for any 

loan made, increased, extended, 

renewed or purchased by these entities. 

The requirement for federally 

regulated lending institutions to 

determine whether a building or mobile 

home securing a loan is located in an 

area having special flood hazards and 

whether flood insurance is available has 

been in effect since the enactment of the 

Flood Disaster Protection Act of 1973, 

although the use of a standard form was 

not required until the enactment of the 

Riegle Community Development and 

Regulatory Improvement Act of 1994. 

The establishment of the Standard 

Flood Hazard Determination form has 

enabled lenders to provide consistent 

information. 

Collection of Information 

Title: Standard Flood Hazard 

Determination Form. 

Type of Information Collection: 

Revision of a currently approved 

information collection. 

OMB Number: 1660–0040. 

FEMA Form: FEMA Form 086–0–32, 

Standard Flood Hazard Determination 

Form (SFHDF). 

Abstract: FEMA Form 086–0–32, 

SFHDF is used by regulated lending 

institutions, federal agency lenders, 

related lenders/regulators, and the 

Government. Federally regulated 

lending institutions complete this form 

when making, increasing, extending, 

renewing or purchasing each loan for 

the purpose is of determining whether 

flood insurance is required and 

available. The form may also be used by 

property owner, insurance agents, 

realtors, community officials for flood 

insurance related documentation. 

Affected Public: Business or other forprofit. 

Number of Respondents: 46,456,460. 

Number of Responses: 46,456,460. 

Estimated Total Annual Burden 

Hours: 15,330,632 hours. 

mstockstill on DSK4VPTVN1PROD with NOTICES