ADDITIONAL POSTERS — TECHNOLOGIES NOT INCLUDED

IN TECHNICAL PRESENTATIONS

Nanoparticles for Imaging: Targeted Nanoparticles That Can Be Imaged Through 

Magnetic Resonance, Optical and Radioisotope Imaging

Martin W. Brechbiel, Radiation Oncology Branch, NCI

Available for licensing and commercial development are patent rights covering tri-imageable 

nanoparticles which have great potential for application in the laboratory and clinic for labeling at 

the cellular level, diagnostics, and drug delivery. The particle includes a silica encased ultrasmall 

superparamagnetic iron oxide (SPIONs) that can be detected using MRI. A fluorescent probe 

(e.g., Cy5.5) for optical imaging is embedded in the silica. The resulting particles are about 20-

25nm in diameter. Target specific antibodies are attached to the surface of the particles. Chelated 

to the antibodies is a radioisotope (e.g., Indium-111) useful for particle quantification and can be 

imaged through techniques such as single photon emission computed tomography (SPECT) or 

positron emission tomography (PET).

Nanoparticles for Imaging and Treatment of Brain Tumors

Hemant Sarin, M.D., Intramural Research Programs, NIBIB

Conventional chemotherapy drugs do not reach therapeutic levels in brain tumor tissue, and do 

not remain in brain tumor tissue for long enough to enter brain tumor cells and kill them. As a 

consequence, these chemotherapy drugs are not effective at treating malignant brain tumors 

growing in patients, even though these drugs are effective at killing brain tumor cells growing in 

culture. This invention claims that intravenously administered functionalized polyamidoamine 

(PAMAM) dendrimers of certain sizes can selectively cross the blood-brain barrier (BBB) of 

malignant brain tumors, and can accumulate over time within individual brain tumor cells. 

Gadolinium and fluorescent probe conjugated dendrimers with these properties can be used for 

simultaneous magnetic resonance and fluorescence imaging of brain tumor cells. Applications 

include anatomic and metabolic imaging of brain and spinal cord tumors for diagnostic and 

therapeutic purposes, intravenous treatment of brain and spinal cord tumors; imaging of 

intravenous drug delivery to brain and spinal cord tumors; and the potential to be used for 

imaging and treatment of other neurological disorders in which the BBB becomes porous.

Hollow Structured Mesoporous Silica Coated MnO Nanoparticles as Highly Efficient T1 

Contrast Agents and Their Applications in MR tracking of Transplanted Mesenchymal 

Stem Cells

Taeho Kim1,2,6, Eric Momin5, Jonghoon Choi1,2,7, Hasan Zaidi5

, Mi-hyun Park6, Vytas Reipa7, 

Alfredo Quinones-Hinojosa5

, Taeghwan Hyeon6, Jeff W. M. Bulte1-4, Assaf A. Gilad1,2*

(

1

Cellular Imaging Section, Institute for Cell Engineering, 2Dept. of Radiology, 3Dept. of 

Biomedical Engineering, 4

Dept. of Chemical & Biomolecular Engineering, 5Dept. of 

Neurological Surgery, The Johns Hopkins University School of Medicine; 6

National Creative 

Research Initiative Center for Oxide Nanocrystalline Materials, School of Chemical and 

Biological Engineering, Seoul National University; 7

CSTL, NIST)

Ultrastable Atomic Force Microscopy: Atomic-scale Stability and Registration at Ambient 

Conditions

Thomas Perkins, JILA, NIST & CU-Boulder, NIST
Computer Aided Detection (CAD) of Colonic Polyps Using CT Colonography (CTC)

Jack Yao, Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, NIH

We have developed advanced image processing and machine learning techniques for computer 

aided detection of colon cancer using CT colonography. Our CAD system achieves high 

sensitivity and specificity. Automated polyp size evaluation provides a consistent way to 

characterize the polyps. The tools are useful for colon cancer screening. Most of our techniques 

are patented and ready for further commercial development. 

Bone Imaging: Bone Mineral Density as a Biomarker for Assessing Bone Health

Herbert S. Bennett, Semiconductor Electronics Division, Andrew Dienstfrey, Information 

Technology Laboratory Office, Tammy Oreskovic, Materials Reliability Division, Lawrence 

Hudson, Ionizing Radiation Division, NIST

Multilayered RF Coil System for Improving Transmit B1 Field Homogeneity in High-Field 

MRI

Alan Koretsky, Jeff H. Duyn, Shumin Wang, Hellmut Merkle, Laboratory of Functional & 

Molecular Imaging, NINDS

We have developed a multilayered radio-frequency (RF) coil system for improving the transmit 

B1 field homogeneity for magnetic resonance imaging (MRI) at high field strengths. The current 

invention aims at manipulating the inhomogeneous profile of the transmit B1 field, which causes 

MR images to become less uniform as the magnetic field strength is increased, by utilizing an 

inner array of RF elements (e.g. surface coils) within and coupled to an outer transmit unit (e.g. a 

birdcage coil or other volume coil). The current design provides an effective approach for 

reducing B1 field homogeneity at high fields and can be implemented without the need for 

independent RF channels, thereby reducing MRI system complexity. Furthermore it can be 

readily implemented on existing MRI coil systems by detuning surface coils rather than 

decoupling them during the transmit phase, thus further reduces the cost of a system. The current 

status of the technology includes development of optimized methods based on real-time 

simulations of specific heads and a working coil for use with phantoms. We are looking for 

commercial partners to further develop the coil system and are working towards finishing the 

design for work in phantoms, the construction of a coil for use on human heads, and looking to 

explore benefits for whole body imaging. 

Chip-Scale Atomic Magnetometers for Low-Cost Biomagnetic Imaging and NMR

Svenja Knappe, John Kitching, Time and Frequency Division, Physics Labs, NIST

Enhancing Bio-imaging Through Chemical and Elemental Mapping of Biological 

Structures

Stephan Stranick, Keana Scott, Surface and Microanalysis Science Division, NIST

Increasing the Throughput of in vitro Assays to Measure the Function of Antibodies to 

Pneumococci

Matthew L. Clarke, Optical Technology Division, NIST

Fluorescence Reporter Proteins for Studying the Protein Trafficking of Malaria Infected 

Human Red Blood Cells

Georgeta Crivat, Guest Researcher, Optical Technology Division, NIST, Laboratory of Malaria 

and Vector Research, NIH/NIAID
Tenascin-C is Unregulated at the End of the Cell Cycle in Proliferating NIH 3T3 

Fibroblasts

Michael Halter, Benjamin L. Stottrup, Kurt J. Langenbach, Alex Tona, Anne L. Plant, John T. 

Elliott, NIST

Neutron Radiography in Biological Systems at Submicrometer Resolution

Jayne B. Morrow, R. David Holbrook, Muhammad Arif, R. Gregory Downing, Brian B. 

Maranville, NIST

Introduction to the NIBIB/NIH Clinical Center Laboratory of Molecular Imaging and 

Nanomedicine 

Xiaoyuan (Shawn) Chen, Laboratory of Molecular Imaging and Nanomedicine, 

NIBIB/ NIH CC

Brief introduction of my laboratory that is divided into 4 sections: PET radiochemistry group, 

biological molecular imaging group, molecular imaging probe toolbox group, and theranostic 

nanomedicine group. We specialize in synthesizing molecular imaging probes for positron 

emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic 

resonance imaging (MRI), optical (bioluminescence, fluorescence and Raman), contrast enhanced 

ultrasound, photoacoustic imaging as well as multimodality imaging. We aim to develop 

molecular imaging toolbox for better understanding of the biology, early diagnosis of diseases, 

monitoring therapy response, and guiding drug discovery and development. Our lab puts special 

emphasis on high sensitivity nanosensors for biomarker detection and theranostic nanomedicine 

for imaging, gene and drug delivery, and monitoring of treatment. A few exemplar images will be 

shown.

NIAID Integrated Research Facility

Richard C. Reba, M.D., Department of Nuclear Medicine, NIAID/NIH Clinical Center

The NIAID Integrated Research Facility (IRF) at Fort Detrick will occupy a unique niche in the 

world of Biosafety Level 4 containment laboratories. In addition to employing state-of-the-art 

laboratory research methods to study the pathogenesis and treatment of diseases caused by 

virulent viruses and bacteria, investigators will make use of an array of imaging instruments to 

track the course of illness in infected animals and assess the efficacy of new vaccines and 

therapies.