Exhibit 10.02 

RATIFICATION AND GUARANTY
        RELATING TO

  THE SERVICE CONTRACT OF MR MATTHEW EMMENS

	
1.      		
Interpretation	
	 
	
1.1      		
In this Ratification and Guaranty:	
	 


	“Agreement” 	 	means the amended and restated
        employment agreement relating to the employment of Matthew Emmens as
        Chairman of the Board of Directors and Chief Executive of Shire Executive
        Services Inc., Chief Executive Officer of Shire Pharmaceuticals Group
        plc and Chairman of the Board of Directors of Shire US Inc.,
        made between Shire Executive Services Inc. and Matthew Emmens and dated
        12th March
    2004, as such agreement may be amended from time to time;
	 	 	 
	“Amendment Agreement”	 	  means the agreement of even
        date with this Ratification and Guaranty between Shire Executive Services
        Inc. and Matthew Emmens pursuant to which certain provisions of the Agreement
    are amended; and
	 	 	 
	“Effective Date”	 	  means the date upon which
    the Amendment Agreement becomes effective in accordance with its terms.


	 	 
	
1.2      		
Unless expressly stated otherwise, all other defined terms in this Ratification and Guaranty shall have the same meaning as is given to them in the Agreement.	
	 
	
2.      		
Ratification and Guaranty	


Shire plc and Shire US Inc. (each a “Guarantor”) hereby confirm and ratify the Agreement and, with effect from the Effective Date, agree (i) to
the provisions thereof and (ii) to be bound by such provisions. For value received and to replace the ratification and guaranty given by Shire Pharmaceuticals Group plc and Shire US Inc. in respect of the Agreement, with effect from the Effective
Date, each Guarantor jointly and severally hereby irrevocably guarantees to the Executive the prompt performance and payment of all obligations of the Company to the Executive under the Agreement. This is a guarantee of performance and payment and
not of collection. The obligations of each Guarantor under this guarantee shall not be affected or impaired by reason of the happening from time to time of any of the following with respect to the Agreement: (i) the waiver by the Executive or the
Company of the performance or observance of any provision of the Agreement; (ii) the modification or amendment (whether material or otherwise) of any of the obligations of the Company or the Executive under the Agreement; (iii) any failure, omission
or delay on the part of the Executive to enforce, assert or exercise any right conferred on the Executive in the Agreement or otherwise; or (iv) any bankruptcy, insolvency or reorganization of, any arrangement or assignment for benefit of creditors
by, or any trusteeship with respect to, the Company or any of its assets. Each Guarantor specifically agrees to be subject to the arbitration and dispute resolution procedures set forth in Section 15.6 of the Agreement and to the jurisdiction of the
state and federal courts in the State of New York, agrees to be bound by an arbitrator’s determinations in any arbitration by the Company and the Executive, agrees not to assert arguments of forum non conveniens and agrees that 














2




service upon it may be made by registered mail, return receipt requested. Each Guarantor shall require any successor (whether direct or indirect, by purchase, merger, consolidation or otherwise) to all or substantially all
its business, assets or stock to expressly assume this guarantee in writing delivered to the Executive and to fulfil the obligations hereunder as if no succession had taken place. Notwithstanding anything herein to the contrary, the obligations of
Shire plc under this Ratification and Guaranty shall not apply to any extent satisfaction of such obligations would cause Sections 309A (2) or (3), or Section 311 of the UK Companies Act of 1985 to be violated.


  	 SHIRE PLC  
	 	 	 
	By:	 
	 	

	 	Name:	 
	 	Title:	 
	 	 	 
	Dated:                      ,
          2005





  	 
	 
	 SHIRE US INC.  
	 	 	 
	By:	 
	 	

	 	Name:	 
	 	Title:	 
	 	 	 
	Dated:                      ,
          2005