EX-4.2



 






Exhibit 4.2




OSI PHARMACEUTICALS, INC.




STOCK PLAN FOR ASSUMED OPTIONS OF PRE-MERGER




EMPLOYEES OF EYETECH PHARMACEUTICALS, INC.




 









 









TABLE OF CONTENTS




	 	 	 	 	 	 	 
	 	 	 	 	PAGE NO.
	SECTION 1. ESTABLISHMENT AND PURPOSE	 	 	1	 
	 
	 	 	 	 	 	 
	SECTION 2. ADMINISTRATION	 	 	1	 
	 
	 	 	 	 	 	 
	(A)

	 	COMMITTEES OF THE BOARD OF DIRECTORS
	 	 	1	 
	(B)

	 	AUTHORITY OF THE BOARD OF DIRECTORS
	 	 	1	 
	 
	 	 	 	 	 	 
	SECTION 3. ELIGIBILITY	 	 	1	 
	 
	 	 	 	 	 	 
	(A)

	 	GENERAL RULE
	 	 	1	 
	(B)

	 	TEN-PERCENT STOCKHOLDERS
	 	 	1	 
	 
	 	 	 	 	 	 
	SECTION 4. STOCK SUBJECT TO PLAN	 	 	2	 
	 
	 	 	 	 	 	 
	SECTION 5. TERMS AND CONDITIONS OF AWARDS OR SALES	 	 	2	 
	 
	 	 	 	 	 	 
	(A)

	 	STOCK PURCHASE AGREEMENT
	 	 	2	 
	(B)

	 	DURATION OF OFFERS AND NONTRANSFERABILITY OF RIGHTS
	 	 	2	 
	(C)

	 	PURCHASE PRICE
	 	 	2	 
	(D)

	 	WITHHOLDING TAXES
	 	 	2	 
	(E)

	 	RESTRICTIONS ON TRANSFER OF SHARES AND MINIMUM VESTING
	 	 	2	 
	 
	 	 	 	 	 	 
	SECTION 6. TERMS AND CONDITIONS OF OPTIONS	 	 	3	 
	 
	 	 	 	 	 	 
	(A)

	 	STOCK OPTION AGREEMENT
	 	 	3	 
	(B)

	 	NUMBER OF SHARES
	 	 	3	 
	(C)

	 	EXERCISE PRICE
	 	 	3	 
	(D)

	 	EXERCISABILITY
	 	 	3	 
	(E)

	 	ACCELERATED EXERCISABILITY
	 	 	3	 
	(F)

	 	BASIC TERM
	 	 	4	 
	(G)

	 	TERMINATION OF SERVICE (EXCEPT BY DEATH)
	 	 	4	 
	(H)

	 	LEAVES OF ABSENCE
	 	 	4	 
	(I)

	 	DEATH OF OPTIONEE
	 	 	4	 
	(J)

	 	RESTRICTIONS ON TRANSFER OF SHARES AND MINIMUM VESTING
	 	 	5	 
	(K)

	 	TRANSFERABILITY OF OPTIONS
	 	 	5	 
	(L)

	 	WITHHOLDING TAXES
	 	 	5	 
	(M)

	 	NO RIGHTS AS A STOCKHOLDER
	 	 	5	 
	(N)

	 	MODIFICATION, EXTENSION AND ASSUMPTION OF OPTIONS
	 	 	6	 
	 
	 	 	 	 	 	 
	SECTION 7. PAYMENT FOR SHARES	 	 	6	 
	 
	 	 	 	 	 	 
	(A)

	 	GENERAL RULE
	 	 	6	 
	(B)

	 	SURRENDER OF STOCK
	 	 	6	 
	(C)

	 	SERVICES RENDERED
	 	 	6	 
	(D)

	 	PROMISSORY NOTE
	 	 	6	 
	(E)

	 	EXERCISE/SALE
	 	 	6	 
	(F)

	 	EXERCISE/PLEDGE
	 	 	7	 
	 
	 	 	 	 	 	 
	SECTION 8. ADJUSTMENT OF SHARES	 	 	7	 
	 
	 	 	 	 	 	 
	(A)

	 	GENERAL
	 	 	7	 
	(B)

	 	MERGERS AND CONSOLIDATIONS
	 	 	7	 
	(C)

	 	RESERVATION OF RIGHTS
	 	 	7	 
	 
	 	 	 	 	 	 
	SECTION 9. SECURITIES LAW REQUIREMENTS	 	 	8	 
	 
	 	 	 	 	 	 
	(A)

	 	GENERAL
	 	 	8	 






i









 






	 	 	 	 	 	 	 
	 	 	 	 	PAGE NO.
	(B)

	 	FINANCIAL REPORTS
	 	 	8	 
	 
	 	 	 	 	 	 
	SECTION 10. NO RETENTION RIGHTS	 	 	8	 
	 
	 	 	 	 	 	 
	SECTION 11. DURATION AND AMENDMENTS	 	 	8	 
	 
	(A)

	 	TERM OF THE PLAN
	 	 	8	 
	(B)

	 	RIGHT TO AMEND OR TERMINATE THE PLAN
	 	 	8	 
	(C)

	 	EFFECT OF AMENDMENT OR TERMINATION
	 	 	8	 
	 
	 	 	 	 	 	 
	SECTION 12. DEFINITIONS	 	 	8	 






ii









 






OSI PHARMACEUTICALS, INC.




STOCK PLAN FOR ASSUMED OPTIONS OF PRE-MERGER EMPLOYEES OF




EYETECH PHARMACEUTICALS, INC.




SECTION 1. ESTABLISHMENT AND PURPOSE.




     Pursuant to an Agreement and Plan of Merger (the “Merger Agreement”) dated August 21, 2005, by
and among OSI Pharmaceuticals, Inc. (the “Company”), Merger EP Corporation (“Merger Sub”) and
Eyetech Pharmaceuticals, Inc.(“Eyetech”), Eyetech has merged with Merger Sub (the “Merger”), and
Eyetech, as the surviving corporation, has become a wholly-owned subsidiary of the Company. In
connection therewith, pursuant to the terms of this Plan, the Company assumes Eyetech’s 2001 Stock
Plan and all option and other awards issued and outstanding thereunder to persons who were
Employees, Consultants or Outside Directors of Eyetech (“Pre-Merger Employees”) prior to the
Merger. The Plan provides both for the direct award or sale of Shares and for the grant of Options
to purchase Shares. Options granted under the Plan may include Nonstatutory Options as well as
ISOs intended to qualify under Section 422 of the Code.



     Capitalized terms are defined in Section 12.



SECTION 2. ADMINISTRATION.




     (a) COMMITTEES OF THE BOARD OF DIRECTORS. The Plan may be administered by one or more Committees.
Each Committee shall consist of one or more members of the Board of Directors who have been
appointed by the Board of Directors. Each Committee shall have such authority and be responsible
for such functions as the Board of Directors has assigned to it. If no Committee has been
appointed, the entire Board of Directors shall administer the Plan. Any reference to the Board of
Directors in the Plan shall be construed as a reference to the Committee (if any) to whom the Board
of Directors has assigned a particular function.



     (b) AUTHORITY OF THE BOARD OF DIRECTORS. Subject to the provisions of the Plan, the Board of
Directors shall have full authority and discretion to take any actions it deems necessary or
advisable for the administration of the Plan. All decisions, interpretations and other actions of
the Board of Directors shall be final and binding on all Purchasers, all Optionees and all persons
deriving their rights from a Purchaser or Optionee.



SECTION 3. ELIGIBILITY.




     (a) GENERAL RULE.Only Employees, Outside Directors and Consultants who are Pre-Merger Employees shall be eligible
for grants under the Plan, and such grants shall be made only for the purpose set forth in Section 1.



     (b) TEN-PERCENT STOCKHOLDERS. A person who owns more than 10% of the total combined voting power
of all classes of outstanding stock of the Company, its Parent or any of its Subsidiaries shall not
be eligible for designation as an Optionee or Purchaser unless (i) the



 









 







Exercise Price is at least
110% of the Fair Market Value of a Share on the date of grant, (ii) the Purchase Price (if any) is
at least 100% of the Fair Market Value of a Share and (iii) in the case of an ISO, such ISO by its
terms is not exercisable after the expiration of five years from the date of grant. For purposes
of this Subsection (b), in determining stock ownership, the attribution rules of Section 424(d) of
the Code shall be applied.



SECTION 4. STOCK SUBJECT TO PLAN.




     Shares offered under the Plan may be authorized but unissued Shares or treasury Shares. The
aggregate number of Shares that may be issued under the Plan (upon exercise of Options or other
rights to acquire Shares) shall not exceed 250,000 Shares, subject to adjustment pursuant to
Section 8. The number of Shares that are subject to Options or other rights outstanding at any
time under the Plan shall not exceed the number of Shares that then remain available for issuance
under the Plan. The Company, during the term of the Plan, shall at all times reserve and keep
available sufficient Shares to satisfy the requirements of the Plan.



SECTION 5. TERMS AND CONDITIONS OF AWARDS OR SALES.




     (a) STOCK PURCHASE AGREEMENT. Each award or sale of Shares under the Plan (other than upon
exercise of an Option) shall be evidenced by a Stock Purchase Agreement between the Purchaser and
the Company. Such award or sale shall be subject to all applicable terms and conditions of the
Plan and may be subject to any other terms and conditions which are not inconsistent with the Plan
and which the Board of Directors deems appropriate for inclusion in a Stock Purchase Agreement.
The provisions of the various Stock Purchase Agreements entered into under the Plan need not be
identical.



     (b) DURATION OF OFFERS AND NONTRANSFERABILITY OF RIGHTS. Any right to acquire Shares under the
Plan (other than an Option) shall automatically expire if not exercised by the Purchaser within 30
days after the grant of such right was communicated to the Purchaser by the Company. Such right
shall not be transferable and shall be exercisable only by the Purchaser to whom such right was
granted.



     (c) PURCHASE PRICE. The Purchase Price of Shares to be offered under the Plan shall not be less
than 85% of the Fair Market Value of such Shares, and a higher percentage may be required by
Section 3(b), subject
to adjustment as provided under the Merger Agreement. Subject to the preceding sentence, the Board
of Directors shall determine the Purchase Price at its sole discretion. The Purchase Price shall
be payable in a form described in Section 7.



     (d) WITHHOLDING TAXES. As a condition to the purchase of Shares, the Purchaser shall make such
arrangements as the Board of Directors may require for the satisfaction of any federal, state,
local or foreign withholding tax obligations that may arise in connection with such purchase.



     (e) RESTRICTIONS ON TRANSFER OF SHARES AND MINIMUM VESTING. Any Shares awarded or sold under the
Plan shall be subject to such special forfeiture conditions, rights of repurchase, rights of first
refusal and other transfer restrictions as the Board of Directors may determine. Such restrictions
shall be set forth in the applicable Stock Purchase Agreement and shall apply in addition to any
restrictions that may apply to holders of Shares generally. In



2









 







the case of a Purchaser who is not
an officer of the Company, an Outside Director or a Consultant:




     (i) Any right to repurchase the Purchaser’s Shares at the original Purchase Price (if
any) upon termination of the Purchaser’s Service shall lapse at least as rapidly as 20% per
year over the five-year period commencing on the date of the award or sale of the Shares;




     (ii) Any such right may be exercised only for cash or for cancellation of indebtedness
incurred in purchasing the Shares; and




     (iii) Any such right may be exercised only within 90 days after the termination of the
Purchaser’s Service.



SECTION 6. TERMS AND CONDITIONS OF OPTIONS.




     (a) STOCK OPTION AGREEMENT. Each grant of an Option under the Plan shall be evidenced by a Stock
Option Agreement between the Optionee and the Company. Such Option shall be subject to all
applicable terms and conditions of the Plan and may be subject to any other terms and conditions
which are not inconsistent with the Plan and which the Board of Directors deems appropriate for
inclusion in a Stock Option Agreement. The provisions of the various Stock Option Agreements
entered into under the Plan need not be identical.



     (b) NUMBER OF SHARES. Each Stock Option Agreement shall specify the number of Shares that are
subject to the Option and shall provide for the adjustment of such number in accordance with
Section 8 and the Merger Agreement. The Stock Option Agreement shall also specify whether the
Option is an ISO or a Nonstatutory Option.



     (c) EXERCISE PRICE. Each Stock Option Agreement shall specify the Exercise Price. Subject to
adjustment as provided in the Merger Agreement, the Exercise Price of an ISO shall not be less than
100% of the Fair Market Value of a Share on the date of grant, and a higher percentage may be
required by Section 3(b). Subject to adjustment as provided in the Merger Agreement, the Exercise
Price of a Nonstatutory Option shall not be less than 85% of the Fair Market Value of a Share on
the date of grant, and a higher percentage may be required by Section 3(b). Subject to the
preceding two sentences, the Exercise Price under any Option shall be determined by the Board of
Directors at its sole discretion. The Exercise Price shall be payable in a form described in
Section 7.



     (d) EXERCISABILITY. Each Stock Option Agreement shall specify the date when all or any installment
of the Option is to become exercisable. In the case of an Optionee who is not an officer of the
Company, an Outside Director or a Consultant, an Option shall become exercisable at least as
rapidly as 20% per year over the five-year period commencing on the date of grant. Subject to the
preceding sentence, the Board of Directors shall determine the exercisability provisions of any
Stock Option Agreement at its sole discretion.



     (e) ACCELERATED EXERCISABILITY. Unless the applicable Stock Option Agreement provides otherwise,
all of an Optionee’s Options shall become exercisable in full if (i) the Company is subject to a
Change in Control before the Optionee’s Service terminates, (ii)



3









 







such Options do not remain
outstanding, (iii) such Options are not assumed by the surviving corporation or its parent and (iv)
the surviving corporation or its parent does not substitute options with substantially the same
terms for such Options.



     (f) BASIC TERM. The Stock Option Agreement shall specify the term of the Option. The term shall
not exceed 10 years from the date of grant, and a shorter term may be required by Section 3(b).
Subject to the preceding sentence, the Board of Directors at its sole discretion shall determine
when an Option is to expire.



     (g) TERMINATION OF SERVICE (EXCEPT BY DEATH). If an Optionee’s Service terminates for any reason
other than the Optionee’s death, then the Optionee’s Options shall expire on the earliest of the
following occasions:




     (i) The expiration date determined pursuant to Subsection (f) above;




     (ii) The date three months after the termination of the Optionee’s Service for any
reason other than Disability, or such later date as the Board of Directors may determine; or




     (iii) The date six months after the termination of the Optionee’s Service by reason of
Disability, or such later date as the Board of Directors may determine.



     The Optionee may exercise all or part of the Optionee’s Options at any time before the expiration
of such Options under the preceding sentence, but only to the extent that such Options had become
exercisable before the Optionee’s Service terminated (or became exercisable as a result of the
termination) and the underlying Shares had vested before the Optionee’s Service terminated (or
vested as a result of the termination). The balance of such Options shall lapse when the
Optionee’s Service terminates. In the event that the Optionee dies after the termination of the
Optionee’s Service but before the expiration of the Optionee’s Options, all or part of such Options
may be exercised (prior to expiration) by the executors or administrators of the Optionee’s estate
or by any person who has acquired such Options directly from the Optionee by beneficiary
designation, bequest or inheritance, but only to the extent that such Options had become
exercisable before the Optionee’s Service terminated (or became exercisable as a result of the
termination) and the underlying Shares had vested before the Optionee’s Service terminated (or
vested as a result of the termination).



     (h) LEAVES OF ABSENCE. For purposes of Subsection (g) above, Service shall be deemed to continue
while the Optionee is on a bona fide leave of absence, if such leave was approved by the Company in
writing and if continued crediting of Service for this purpose is expressly required by the terms
of such leave or by applicable law (as determined by the Company).



     (i) DEATH OF OPTIONEE. If an Optionee dies while the Optionee is in Service, then the Optionee’s
Options shall expire on the earlier of the following dates:




     (i) The expiration date determined pursuant to Subsection (f) above; or



4









 







     (ii) The date 12 months after the Optionee’s death, or such later date as the Board of
Directors may determine.



All or part of the Optionee’s Options may be exercised at any time before the expiration of such
Options under the preceding sentence by the executors or administrators of the Optionee’s estate or
by any person who has acquired such Options directly from the Optionee by beneficiary designation,
bequest or inheritance, but only to the extent that such Options had become exercisable before the
Optionee’s death (or became exercisable as a result of the death) and the underlying Shares had
vested before the Optionee’s death (or vested as a result of the Optionee’s death). The balance of
such Options shall lapse when the Optionee dies.



     (j) RESTRICTIONS ON TRANSFER OF SHARES AND MINIMUM VESTING. Any Shares issued upon exercise of an
Option shall be subject to such special forfeiture conditions, rights of repurchase, rights of
first refusal and other transfer restrictions as the Board of Directors may determine. Such
restrictions shall be set forth in the applicable Stock Option Agreement and shall apply in
addition to any restrictions that may apply to holders of Shares
generally. In the case of an Optionee who is not an officer of the Company, an Outside Director or
a Consultant:




     (i) Any right to repurchase the Optionee’s Shares at the original Exercise Price upon
termination of the Optionee’s Service shall lapse at least as rapidly as 20% per year over
the five-year period commencing on the date of the option grant;




     (ii) Any such right may be exercised only for cash or for cancellation of indebtedness
incurred in purchasing the Shares; and




     (iii) Any such right may be exercised only within 90 days after the later of (A) the
termination of the Optionee’s Service or (B) the date of the option exercise.



     (k) TRANSFERABILITY OF OPTIONS. An Option shall be transferable by the Optionee only by (i) a
beneficiary designation, (ii) a will or (iii) the laws of descent and distribution, except as
provided in the next sentence. If the applicable Stock Option Agreement so provides, an NSO shall
also be transferable by the Optionee by (i) a gift to a member of the Optionee’s Immediate Family
or (ii) a gift to an inter vivos or testamentary trust in which members of the Optionee’s Immediate
Family have a beneficial interest of more than 50% and which provides that such NSO is to be
transferred to the beneficiaries upon the Optionee’s death. An ISO may be exercised during the
lifetime of the Optionee only by the Optionee or by the Optionee’s guardian or legal
representative.



     (l) WITHHOLDING TAXES. As a condition to the exercise of an Option, the Optionee shall make such
arrangements as the Board of Directors may require for the satisfaction of any federal, state,
local or foreign withholding tax obligations that may arise in connection with such exercise. The
Optionee shall also make such arrangements as the Board of Directors may require for the
satisfaction of any federal, state, local or foreign withholding tax obligations that may arise in
connection with the disposition of Shares acquired by exercising an Option.



     (m) NO RIGHTS AS A STOCKHOLDER. An Optionee, or a transferee of an Optionee, shall have no rights
as a stockholder with respect to any Shares covered by the



5









 







Optionee’s Option until such person
becomes entitled to receive such Shares by filing a notice of exercise and paying the Exercise
Price pursuant to the terms of such Option.



     (n) MODIFICATION, EXTENSION AND ASSUMPTION OF OPTIONS. Within the limitations of the Plan, the
Board of Directors may modify, extend or assume outstanding Options or may accept the cancellation
of outstanding Options (whether granted by the Company or another issuer) in return for the grant
of new Options for the same or a different number of Shares and at the same or a different Exercise
Price. The foregoing notwithstanding, no modification of an Option shall, without the consent of
the Optionee, impair the Optionee’s rights or increase the Optionee’s obligations under such
Option.



SECTION 7. PAYMENT FOR SHARES.




     (a) GENERAL RULE. The entire Purchase Price or Exercise Price of Shares issued under the Plan
shall be payable in cash or cash equivalents at the time when such Shares are purchased, except as
otherwise provided in this Section 7.



     (b) SURRENDER OF STOCK. To the extent that a Stock Option Agreement so provides, all or any part
of the Exercise Price may be paid by surrendering, or attesting to the ownership of, Shares that
are already owned by the Optionee. Such Shares shall be surrendered to the Company in good form
for transfer and shall be valued at their Fair Market Value on the date when the Option is
exercised. The Optionee shall not surrender, or attest to the ownership of, Shares in payment of
the Exercise Price if such action would cause the Company to recognize compensation expense (or
additional compensation expense) with respect to the Option for financial reporting purposes.



     (c) SERVICES RENDERED. At the discretion of the Board of Directors, Shares may be awarded under
the Plan in consideration of services rendered to the Company, a Parent or a Subsidiary prior to
the award.



     (d) PROMISSORY NOTE. To the extent that a Stock Option Agreement or Stock Purchase Agreement so
provides, all or a portion of the Exercise Price or Purchase Price (as the case may be) of Shares
issued under the Plan may be paid with a full-recourse promissory note. However, the par value of
the Shares, if newly issued, shall be paid in cash or cash equivalents. The Shares shall be
pledged as security for payment of the principal amount of the promissory note and interest
thereon. The interest rate payable under the terms of the promissory note shall not be less than
the minimum rate (if any) required to avoid the imputation of additional interest under the Code.
Subject to the foregoing, the Board of Directors (at its sole discretion) shall specify the term,
interest rate, amortization requirements (if any) and other provisions of such note.



     (e) EXERCISE/SALE. To the extent that a Stock Option Agreement so provides, and if Stock is
publicly traded, payment may be made all or in part by the delivery (on a form prescribed by the
Company) of an irrevocable direction to a securities broker approved by the Company to sell Shares
and to deliver all or part of the sales proceeds to the Company in payment of all or part of the
Exercise Price and any withholding taxes.



6









 





     (f) EXERCISE/PLEDGE. To the extent that a Stock Option Agreement so provides, and if Stock is
publicly traded, payment may be made all or in part by the delivery (on a form prescribed by the
Company) of an irrevocable direction to pledge Shares to a securities broker or lender approved by
the Company,
as security for a loan, and to deliver all or part of the loan proceeds to the Company in payment
of all or part of the Exercise Price and any withholding taxes.



SECTION 8. ADJUSTMENT OF SHARES.




     (a) GENERAL. In the event of a subdivision of the outstanding Stock, a declaration of a dividend
payable in Shares, a declaration of an extraordinary dividend payable in a form other than Shares
in an amount that has a material effect on the Fair Market Value of the Stock, a combination or
consolidation of the outstanding Stock into a lesser number of Shares, a recapitalization, a
spin-off, a reclassification or a similar occurrence, the Board of Directors shall make appropriate
adjustments in one or more of (i) the number of Shares available for future grants under Section 4,
(ii) the number of Shares covered by each outstanding Option or (iii) the Exercise Price under each
outstanding Option.



     (b) MERGERS AND CONSOLIDATIONS. In the event that the Company is a party to a merger or
consolidation, outstanding Options shall be subject to the agreement of merger or consolidation.
Such agreement shall provide for:




     (i) The continuation of such outstanding Options by the Company (if the Company is the
surviving corporation);




     (ii) The assumption of the Plan and such outstanding Options by the surviving
corporation or its parent;




     (iii) The substitution by the surviving corporation or its parent of options with
substantially the same terms for such outstanding Options;




     (iv) The full exercisability of such outstanding Options and full vesting of the Shares
subject to such Options, followed by the cancellation of such Options; or




     (v) The settlement of the full value of such outstanding Options (whether or not then
exercisable) in cash or cash equivalents, followed by the cancellation of such Options.



     (c) RESERVATION OF RIGHTS. Except as provided in this Section 8, an Optionee or Purchaser shall
have no rights by reason of (i) any subdivision or consolidation of shares of stock of any class,
(ii) the payment of any dividend or (iii) any other increase or decrease in the number of shares of
stock of any class. Any issuance by the Company of shares of stock of any class, or securities
convertible into shares of stock of any class, shall not affect, and no adjustment by reason
thereof shall be made with respect to, the number or Exercise Price of Shares subject to an Option.
The grant of an Option pursuant to the Plan shall not affect in any way the right or power of the
Company to make adjustments, reclassifications, reorganizations or changes of its capital or
business structure, to merge or consolidate or to dissolve, liquidate, sell or transfer all or any part of
its business or assets.



7









 





SECTION 9. SECURITIES LAW REQUIREMENTS.




     (a) GENERAL. Shares shall not be issued under the Plan unless the issuance and delivery of such
Shares comply with (or are exempt from) all applicable requirements of law, including (without
limitation) the Securities Act of 1933, as amended, the rules and regulations promulgated
thereunder, state securities laws and regulations, and the regulations of any stock exchange or
other securities market on which the Company’s securities may then be traded.



     (b) FINANCIAL REPORTS. The Company each year shall furnish to Optionees, Purchasers and
stockholders who have received Stock under the Plan its balance sheet and income statement, unless
such Optionees, Purchasers or stockholders are key Employees whose duties with the Company assure
them access to equivalent information. Such balance sheet and income statement need not be
audited.



SECTION 10. NO RETENTION RIGHTS.




     Nothing in the Plan or in any right or Option granted under the Plan shall confer upon the
Purchaser or Optionee any right to continue in Service for any period of specific duration or
interfere with or otherwise restrict in any way the rights of the Company (or any Parent or
Subsidiary employing or retaining the Purchaser or Optionee) or of the Purchaser or Optionee, which
rights are hereby expressly reserved by each, to terminate his or her Service at any time and for
any reason, with or without cause.



SECTION 11. DURATION AND AMENDMENTS.




     (a) TERM OF THE PLAN. The Plan, as set forth herein, shall be effective as of closing date of the
Merger. The Plan shall terminate automatically on April 3, 2011. The Plan may be terminated on
any earlier date pursuant to Subsection (b) below.



     (b) RIGHT TO AMEND OR TERMINATE THE PLAN. The Board of Directors may amend, suspend or terminate
the Plan at any time and for any reason; provided, however, that any amendment of the Plan which
increases the number of Shares available for issuance under the Plan (except as provided in Section
8), or which materially changes the class of persons who are eligible for the grant of ISOs, shall
be subject to the approval of the Company’s stockholders. Stockholder approval shall not be
required for any other amendment of the Plan.



     (c) EFFECT OF AMENDMENT OR TERMINATION. No Shares shall be issued or sold under the Plan after the termination thereof, except upon
exercise of an Option granted prior to such termination. The termination of the Plan, or any
amendment thereof, shall not affect any Share previously issued or any Option previously granted
under the Plan.



SECTION 12. DEFINITIONS.




     In addition to the definitions set forth in Section 1 above,



     (a) “BOARD OF DIRECTORS” shall mean the Board of Directors of the Company, as constituted from
time to time.



8









 





     (b) “CHANGE IN CONTROL” shall mean:




     (i) The consummation of a merger or consolidation of the Company with or into another
entity or any other corporate reorganization, if persons who were not stockholders of the
Company immediately prior to such merger, consolidation or other reorganization own
immediately after such merger, consolidation or other reorganization 50% or more of the
voting power of the outstanding securities of each of (A) the continuing or surviving entity
and (B) any direct or indirect parent corporation of such continuing or surviving entity; or




     (ii) The sale, transfer or other disposition of all or substantially all of the
Company’s assets.


A transaction shall not constitute a Change in Control if its sole purpose is to change the state
of the Company’s incorporation or to create a holding company that will be owned in substantially
the same proportions by the persons who held the Company’s securities immediately before such
transaction.




     (c) “CODE” shall mean the Internal Revenue Code of 1986, as amended.



     (d) “COMMITTEE” shall mean a committee of the Board of Directors, as described in Section
2(a).



     (e) “CONSULTANT” shall mean a person who performs bona fide services for the Company or a
Subsidiary as a consultant or advisor, excluding Employees and Outside Directors.



     (f) “DISABILITY” shall mean that the Optionee is unable to engage in any substantial gainful
activity by reason of any medically determinable physical or mental impairment.



     (g) “EMPLOYEE” shall mean any individual who is a common-law employee of the Company or a
Subsidiary.



     (h) “EXERCISE PRICE” shall mean the amount for which one Share may be purchased upon exercise
of an Option, as specified by the Board of Directors in the applicable Stock Option Agreement.



     (i) “FAIR MARKET VALUE” shall mean the fair market value of a Share, as determined by the
Board of Directors in good faith. Such determination shall be conclusive and binding on all
persons.



     (j) “IMMEDIATE FAMILY” shall mean any child, stepchild, grandchild, parent, stepparent,
grandparent, spouse, sibling, mother-in-law, father-in-law, son-in-law, daughter-in-law,
brother-in-law or sister-in-law and shall include adoptive relationships.



     (k) “ISO” shall mean an employee incentive stock option described in Section 422(b) of the
Code.



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     (l) “NONSTATUTORY OPTION” shall mean a stock option not described in Sections 422(b) or 423(b)
of the Code.



     (m) “OPTION” shall mean an ISO or Nonstatutory Option granted under the Plan and entitling the
holder to purchase Shares.



     (n) “OPTIONEE” shall mean a person who holds an Option.



     (o) “OUTSIDE DIRECTOR” shall mean a member of the Board of Directors of Eyetech who is not an
Employee.



     (p) “PLAN” shall mean this OSI Pharmaceuticals, Inc. Stock Plan for Assumed Options of
Pre-Merger Employees of Eyetech Pharmaceuticals, Inc.



     (q) “PURCHASE PRICE” shall mean the consideration for which one Share may be acquired under
the Plan (other than upon exercise of an Option), as specified by the Board of Directors.



     (r) “PURCHASER” shall mean a person to whom the Board of Directors has offered the right to
acquire Shares under the Plan (other than upon exercise of an Option).



     (s) “SERVICE” shall mean service as an Employee, Outside Director or Consultant.



     (t) “SHARE” shall mean one share of Stock, as adjusted in accordance with Section 8 (if
applicable).



     (u) “STOCK” shall mean the common stock of the Company, with a par value of $0.01 per Share.



     (v) “STOCK OPTION AGREEMENT” shall mean the agreement between the Company and an Optionee that
contains the terms, conditions and restrictions pertaining to the Optionee’s Option.



     (w) “STOCK PURCHASE AGREEMENT” shall mean the agreement between the Company and a Purchaser
who acquires Shares under the Plan that contains the terms, conditions and restrictions pertaining
to the acquisition of such Shares.



     (x) “SUBSIDIARY” shall mean any corporation (other than the Company) in an unbroken chain of
corporations beginning with the Company, if each of the corporations other than the last
corporation in the unbroken chain owns stock possessing 50% or more of the total combined voting
power of all classes of stock in one of the other corporations in such chain. A corporation that
attains the status of a Subsidiary on a date after the adoption of the Plan shall be considered a
Subsidiary commencing as of such date.




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