Lease Agreement, executed November 2, 2005



  
 Exhibit 10.4

  
 LEASE AGREEMENT 
  
 between 
  
 Medeon Fastigheter AB 
  
 and 
  
 ACADIA Pharmaceuticals Inc. 







 

 








					
	Wihlborgs	 	LEASE AGREEMENT	 	 
	 	FOR NON-RESIDENTIAL PREMISES	 	No. 4881-20000

  

			
	 The undersigned have this day entered into the following Lease Agreement
	  	An X in a box means that the text following thereafter applies.

  

																					
	Landlord	 	Medeon Fastigheter AB	  	 National ID/company registration no.
 556034-1140

	Tenant	 	ACADIA Pharmaceuticals AB	  	 National ID/company registration no.
 556666-6805

	 Premises Address,
 etc
	 	 Municipality:
 Malmö
	 	 Property designation
 Forskaren
1

	 	 Street
 P A Hanssonsväg 35,
Malmö
	  	Floor/building	  	 Apartment no.
             20000

	 	 Billing Address
 Medeon -
Malmö Science Park 205 12 Malmö
	  	 
	 Condition and use
 of
premises
	 	Unless otherwise stated, the premises and appurtenant storage areas are let in their existing condition for use as: Kontor och
	 Size and extent of
 premises
	 	Retail space	 	Office space	  	Storage space	  	Other space
	 	 	Floor	 	Sq. m.	 	Floor	 	Sq. m. ca	  	Floor	 	Sq. m.	  	Floor	 	Sq. m.	  	Floor	  	Sq. m.
	 	 	 	 	 	 	 1
 3
	 	 960
 890
	  	2	 	930	  	 	 	 	  	 	  	19 ca Gasforrad
	 	 	The designated areas
	 	 	 ̈ have	 	x have not	 	             been measured jointly prior to the execution of the Agreement
			
	 	 	Should the area shown in the Agreement deviate from that actually measured, this does not entitle the Tenant to any repayment of rent nor entitle the Landlord to any increased
rent	  	 Appendix
 1A-1D

			
	 	 	 x The extent of the leased premises is marked on appended plan(s)
	  	 
							
	 	 	x access for cars loading/unloading	 	 ̈ place for sign	 	 ̈ place for display cabinet/
vending machine	 	 ̈ parking space(s) for
            car(s)	 	 ̈ garage space(s) for
            car(s)	 	 ̈
	Furnishings/ Fixtures/Fittings	 	 The premises are let:
  ̈      without furnishings/fixtures/fittings specific to
the Tenants use of the premises
	 	 x      with furnishings/fixtures/fittings
specific to the Tenants use of the premises according to appendix
	  	 Appendix
 7

		
	 	 	 Unless otherwise agreed upon, at the termination of the tenancy, the Tenant shall remove all property belonging to him and
surrender the premises in acceptable condition.
 The parties agree to carry out a joint inspection of the premises not later than the last day of the
tenancy. If, as a result of the Tenant’s actions – carried out with or without the Landlord’s consent – the premises upon surrender should contain material, which it had not previously been agreed that the Landlord should be
responsible for, the Tenant shall remove such material or pay the Landlord’s expenses in so doing, including but not limited to, transportation costs, waste disposal taxes and storage charges.

		
	Telephone lines	 	  ̈      The Tenant shall pay for the installation of the necessary telephone lines from a connection point designated by the service provider to those points in the premises
chosen by the Tenant in consultation with the Landlord.
  
 x      The Landlord shall pay for corresponding installation of lines to the premises. The installation of lines inside the premises shall be
carried out by the Tenant in consultation with the Landlord; the cost, however, to be borne by the Tenant.

		
	Data communication lines	 	  ̈      The Tenant shall pay for the installation of the necessary data communication lines from a connection point designated by the service provider to those points in the
premises chosen by the Tenant in consultation with the Landlord.
  
 x      The Landlord shall pay for corresponding installation of lines to the premises. The installation of lines inside the premises shall be
carried out by the Tenant in consultation with the Landlord; the cost, however, to be borne by the Tenant.

			
	Term of lease	 	 Commencing
 2005-06-01
	 	 Up to and including
 2015-05-31

		
	Termination/ Extensions	 	 Notice of termination of this Agreement must be given in writing at least
    12     months prior to the expiry of this Agreement.
  
 In the absence thereof, this Agreement is extended by a term of     5     years at a
time.

				
	 Heating and
 hot water
	 	Requisite heating of the premises is provided by	  	x the Landlord	 	 ̈ the Tenant
	 	 	Hot water is provided	 	x throughout the year	  	 ̈ not provided	  	 ̈

  

					
	 Notice
 Note that in certain cases, in addition
to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s
right to a reduction of rent in conjunction with customary maintenance. In addition, see instructions prepared by the organisations.
	  	 

  


					
	 Swedish Property Federation form no. 12B, prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels and
Restaurants Association (SHR). Copying prohibited.
 Notice: This is a translation into English of form no. 12B
 License number: 902745460-000058. Version 6.01. Registered to: Wihlborgs Fastigheter AB (publ.)
	  	Initial	  	Initial

  
  

 Page 1(4) 









					
	 	 	LEASE AGREEMENT	 	 
	 	 	FOR NON-RESIDENTIAL PREMISES	 	No. 4881-20000

  

			
	 The undersigned have this day entered into the following Lease Agreement
	  	An X in a box means that the text following thereafter applies.

  

											
	 Rent
	  	 SEK
 7 400
000:—              
	  	Per annum comprising	  	 ̈ total rent	  	x rent excluding supplements marked below
			
	 Index clause
	  	x Changes to the above-stated rent will be effected pursuant to the appended index clause	  	 Appendix
 3

				
	 Heating and hot water costs
	  	 Fuel/heating supplement payable in accordance with
 x appended clause
	  	enl. sjalvkostnad	  	 Appendix
 4

				
	 Water and sewerage cost
	  	 Water and sewerage supplement payable in accordance
 x with appended clause
	  	enl. sjalvkostnad	  	 Appendix
 4

				
	 Cooling Ventilation
	  	 Costs for the operation of special cooling and ventilation appliances
 x shall be reimbursed in accordance with appended clause
	  	enl. sjalvkostnad	  	 Appendix
 4

			
	 Electricity
	  	 ̈ included in rent	  	x Tenant has own contract with the provider
			
	 Cleaning of Stairwell
	  	 ̈ included in rent	  	x arranged for and paid for by the Tenant
		
	 Refuse and waste removal
	  	 Insofar as the Landlord is responsible for the provision of storage space for refuse/waste, and arranging for the removal of such
refuse/waste, it is the Tenant’s responsibility to sort and deposit refuse/waste in the appropriate containers as directed, in their designated place, as well as without recompense contribute towards further and/or additional sorting, as
discussed by the Landlord.
  
 Refuse and waste
removal

		
	 	  	  ̈       included in rent

		
	 	  	 x      Arranged for and paid for by the Tenant (the
Landlord however shall provide the necessary refuse/waste containers and the requisite storage space for such)

		
	 	  	  ̈       Included in rent with respect to the types of refuse/waste indicated below. The Tenant shall be responsible for, and pay for the costs of, collection, sorting, storage and transportation
of the categories of refuse/waste not indicated below which are to be found on the Tenant’s premises.

				
	 	  	 ̈ household waste	  	 ̈ fluorescent tubes	  	  ̈        hard plastic packaging

				
	 	  	 ̈ heavy refuse	  	 ̈ metal packaging	  	  ̈        hazardous waste pursuant to the Hazardous Waste Ordinance (1996:971)

				
	 	  	 ̈ compostable waste	  	 ̈ clear glass containers	  	 x     Bil 4


				
	 	  	 ̈ newspapers	  	 ̈ coloured glass containers	  	  ̈


				
	 	  	 ̈ batteries	  	 ̈ cardboard packaging	  	  ̈


					
	 Snow clearance and gritting
	  	 ̈ included in rent	  	 ̈ to be arranged for and paid for by the
Tenant	  	x as per appendix	  	 Appendix
 4

				
	 Property taxes
	  	 ̈ included in rent	  	x reimbursement payable as per special agreement	  	 Appendix
 5

		
	Unforeseen costs	  	Where, following the execution of this Agreement, unforeseen increases in costs arise in relation to the property as a consequence of:
		
	 	  	 a)        the introduction of, or increases in taxes, charges or duties levied
specifically on the property as a result of decision taken by Parliament, Government, municipalities, or other relevant authorities;

		
	 	  	 b)        general rebuilding measures or such like in respect of the property which do
not relate solely to the premises and which the Landlord is obliged to execute as a result of decisions of the Parliament, Government, municipalities, or other relevant authorities;

		
	 	  	The Tenant shall, commencing at the time of the cost increase, reimburse the Landlord in relation to that proportion of the total annual increase in costs for the property
represented by the premises.
		
	 	  	The proportion represented by the premises is 100 per cent. Where the proportion has not been indicated, it shall be comprised of that proportion of the total rents for
premises (excluding any value-added tax) represented by the Tenant’s rent (excluding any value-added tax) at the time of the increase in costs in respect of unlet premises, the market rent for the premises shall be
estimated.
		
	 	  	“Taxes” in accordance with a) above does not refer to value-added tax and property tax to the extent that reimbursement in respect of this is paid as per agreement.
“Unforeseen costs” means such costs as were not decided upon by the authorities as set forth in sections a) and b) at the inception of the Agreement. Reimbursement shall be paid in the same manner as set forth below for rental
payments.

  

					
	 Notice
 Note that in certain cases, in addition
to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s
right to a reduction of rent in conjunction with customary maintenance. In addition, see instructions prepared by the organisations.
	  	 

  


					
	 Swedish Property Federation form no. 12B, prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels and
Restaurants Association (SHR). Copying prohibited.
 Notice: This is a translation into English of form no. 12B
 License number: 90274560-000058. Version 6.01. Registered to: Wihlborgs Fastigheter AB (publ.)
	  	Initial	  	Initial

  
  

 Page 2(4) 









					
	 	 	LEASE AGREEMENT	  	 
	 	 	FOR NON-RESIDENTIAL PREMISES	  	No. 4881-20000
		
	The undersigned have this day entered into the following Lease Agreement	  	An X in a box means that the text following thereafter applies.

  

											
	Value-added tax (VAT)	  	x The property owner/Landlord is liable to pay value-added tax for the
letting of the premises. In addition to rent, the Tenant
shall on each occasion
pay the VAT currently applicable.
		
	 	  	 ̈ Where, following a decision by the Tax
Authorities, the property owner/
Landlord becomes liable to pay VAT to the letting of the premises, the Tenant
shall on each occasion in addition to the rent pay the VAT currently
applicable.
		
	 	  	The VAT paid together with rent shall be calculated on the stated rental
amount and where applicable on supplemental charges and other
reimbursements paid in accordance
with the Agreement, pursuant to the rules
applicable at the time in respect of VAT payable on rent.
		
	 	  	Where the Landlord becomes liable to pay VAT pursuant to the provisions of
the Value Added Tax Act as a consequence of the Tenant’s independent
actions, such as a
subletting of the premises (including subletting to its own
company) or assignment, the Tenant shall reimburse the Landlord in full. In
addition, the Tenant shall reimburse the Landlord in respect of the increased
costs arising as a
consequence of the Landlord’s loss of the entitlement to
deduct VAT on operating expenses incurred as a consequence of the Tenant’s
actions.
				
	Payment of rent	  	The rent shall be paid in advance without prior
demand, not later than the last working day prior
to the commencement of	  	Postal giro
no.	  	Bank
giro no.
						
	 	  	 ̈ each calendar month	  	x each quarter	  	By direct
transfer
to either
of
following
accounts	  	enl avi	  	enl. avi
		
	 Interest, Payment
 reminders
	  	Upon delay in the payment of rent, the Tenant shall pay interest in accordance
with the Interest Act as well as compensation for written payment reminders
in accordance
with the Debt Recovery Act, etc. Compensation for payment
reminders shall on each occasion be paid in an amount currently applicable
pursuant to the Debt Recovery Ordinance, etc.
				
	Maintenance, etc.	  	 ̈ The Landlord shall carry out and bear the
cost
of necessary maintenance of the premises and
furnishings/fittings/fixtures supplied by him.	  	However,
the Tenant
shall be
responsible
for	  	Appendix
				
	 	  	 ̈ The Tenant shall carry out and bear the cost
of
necessary maintenance of the surface of floors,
walls and ceilings, as well as of furnishings/
fittings/fixtures provided by the Landlord.	  	In addition,
the Tenant’s
maintenance
obligations
includes	  	Appendix  

		
	 	  	Where the Tenant does not fulfill his maintenance obligations and does not
within a reasonable time carry out rectification works following a written
demand, then the
Landlord shall be entitled to fulfill these obligations at the
Tenant’s expense.
				
	 	  	x The allocation of the maintenance obligations
is set forth as per separate appendix.	  	Gransd.lista	  	Appendix
6
		
	 Management and
 operation
	  	Unless otherwise agreed, the Landlord shall, where applicable, manage,
operate, and maintain the public and common areas.
		
	 	  	The Tenant shall not be entitled, without the Landlord’s written consent to
carry out any fitting out and/or installation or alteration works within the
premises or
otherwise within the property, which directly effects the
structural components of the building or installations important to the
functioning of the property, such as water and sewerage, electricity,
ventilation systems, etc., which are the
property of the Landlord.
		
	 	  	Sprinkler heads and ventilation equipment may not be covered by any
fixtures/fittings by the Tenant in such a manner as to reduce the functioning
of such equipment. In
conjunction with the performance of fitting out works,
the Tenant shall ensure that the functioning of radiators and other heating
equipment is maintained in all significant respects.
		
	Inspections	  	Where any defects and/or deficiencies are found subsequent to an inspection
by a relevant authority, in the electrical and sprinkler equipment which is
the









											
	 	  	property of the Tenant, the Tenant shall, at his own cost and
within the period prescribed by the relevant authority,
carry out any measures required. Where the Tenant
has not
rectified the defects and/or deficiencies within the assessed
time, the Landlord shall be entitled, at the Tenant’s expense,
to carry out such measures as are required by the relevant
authority.	  	 
			
	 Access to certain
 spaces
	  	The Tenant shall keep areas to which the maintenance
personnel and personnel from the energy utilities, water and
sewerage utilities, the telephone company, and any
like
organization must have access to, easily accessible by
keeping such areas free of cupboards, crates, goods, or any
other obstruction.	  	 
	 Building material
 specifications
	  	Whether, pursuant to the provisions of this Agreement or
otherwise, the Tenant performs maintenance, improvement,
or alteration works in respect of the premises, the
Tenant
shall provide the Landlord, in good time prior to the
execution of such work, with specifications of the building
materials – to the extent such have been prepared – for the
products and materials to be used on the
premises.	  	 
			
	 Planning and
 Building Code
 (PBL) Insts.
	  	Where the Tenant undertakes alterations to the premises
without the requisite construction permit and, as a
consequence thereof the Landlord is compelled to
pay
construction fines or supplemental fees pursuant to the rules
set forth in the Planning and Building Code (PBL), the
Tenant shall reimburse the Landlord in respect of this.	  	 
			
	Reduction of rent	  	The Tenant shall not be entitled to a reduction in rent for
the period during which the Landlord allows work to be
carried out in order to place the premises in the
agreed
condition, or other works specifically set forth in the
Agreement. SEE GENERAL AGREEMENT.	  	 
			
	 	  	x The Tenant’s right to a reduction in rent during the
Landlord’s performance of customary maintenance of the
leased
premises or the property shall be governed by a
separate appendix.	  	Appendix
2
					
	 Regulations
 imposed by
 relevant
 authorities, etc.
	  	 ̈ The Landlord	  	x The
Tenant	  	shall be solely responsible for, and bear the cost of, undertaking measures which may be required for the intended use of the premises by insurance companies, building
authorities, environmental or health authorities, fire departments, or other relevant authorities after the date of taking possession. The Tenant shall consult with the Landlord prior to undertaking any such measures.	  	 

  

					
	 Notice
 Note that in certain cases, in addition
to marking a box with an X, an appendix must be appended to the Agreement in order for the agreement set forth in such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause and the Tenant’s
right to a reduction of rent in conjunction with customary maintenance. In addition, see instructions prepared by the organisations.
	  	 

  


					
	 Swedish Property Federation form no. 12B, prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels and
Restaurants Association (SHR). Copying prohibited.
 Notice: This is a translation into English of form no. 12B
 License number: 902745460-000058. Version 6.01. Registered to: Wihlborgs Fastigheter AB (publ.)
	  	Initial	  	Initial

  
  

 Page 3(4) 









					
	 	 	LEASE AGREEMENT	 	 
	 	 	FOR NON-RESIDENTIAL PREMISES	 	No. 4881-20000


			
		
	The undersigned have this day entered into the following Lease Agreement	 	An X in a box means that the text following thereafter applies.


											
		
	Signs, awnings, windows, doors, etc.	  	Following consultation with the Landlord, the Tenant shall be entitled to display a customary business sign provided that the Landlord has not reasonably denied the same and
that the Tenant has obtained the requisite permit from the relevant authority. Upon surrender of the premises, the Tenant shall restore the facade to of the building to an acceptable condition. In conjunction with more extensive property
maintenance, such as the renovation of facades, etc. the Tenant shall, at its own cost and without compensation, dismantle and reassemble signs, awnings, and antennas. The Landlord undertakes not to fix vending machines and display cabinets on the
exterior walls of the premises let to the Tenant without the Tenant’s consent, and grants to the Tenant an option to fix vending machines and display cabinets on the walls in question.
						
	 	  	 ̈ The Landlord	  	 	  	 	 	 	  	 
						
	 	  	 	  	Is liable for any damage due to negligence of malicious intent to	  	 	 	 	  	 
						
	 	  	x The Tenant	  	 	  	x windows	 	 ̈ display/shop windows	  	x entrance doors
						
	 	  	 	  	 	  	 ̈ signs	 	 ̈	  	 
		
	 	  	  ̈ The Tenant shall purchase and maintain glass insurance with respect to displaying windows and entrance doors appurtenant to the premises.

				
	Locks	  	 ̈ The Landlord	  	x The Tenant	  	shall equip the premises with such locks and anti-theft devices as may be required to ensure the validity of the Tenant’s business insurance.
		
	Force majeure	  	The Landlord shall not be compelled to perform the obligations under this Agreement or pay any damages where, as a consequence of acts of war or riots, work stoppages, blockages,
fires, explosions, or intervention by a public authority over which the Landlord has no control and which could not have been foreseen, and the Landlord is prevented entirely from performing his obligations or may only be able to do so at abnormally
high cost.
			
	Security	  	This Agreement is contingent upon the provision of security in the form of a	  	Appendix
						
	 	  	 ̈ Bank guarantee	  	 ̈ Personal guarantee	  	 ̈	 	To be provided no later than	  	 
			
	Special provisions	  	 Särskilda Bestämmelser
	  	 Appendix
 7

		
	Signature	  	This Agreement which may not be registered without specific consent, has been prepared in two identical counterparts of which each party has received one. All prior agreements
between the parties with respect to these premises shall cease to apply commencing on the date of execution of this Agreement.
			
	 	  	Place/date	 	Place/date
				
	 	  	Landlord	  	 This is just a translation.
 Do
not sign here!
 Sign the Swedish form!
	 	Tenant
			
	 	  	Printed name	 	Printed name
		
	Agreement with respect to the surrender of the premises	  	 As a consequence of an agreement entered into this day, the Agreement shall cease to apply
 commencing
                                        
                    , at which time the Tenant undertakes to surrender the premises.

			
	 	  	Place/date	 	Place/date
			
	 	  	Landlord	 	Tenant
		
	Assignment	  	This Lease Agreement is hereby assigned to commencing
					
	 	  	Assignor	  	 	  	Assignee	 	National ID/company regulation no.
						
	The above-referenced assignment is hereby approved	  	Place/date	  	 	  	Landlord	 	 	  	 

  
  

					
	 Notice
 Note that in certain cases,
in addition to marking a box with an X, an appendix must be appended to the Agreement in order for the
agreement set forth in such appendix to be binding. This applies, for example, with respect to an index clause, a property tax clause
and
the Tenant’s right to a reduction of rent in conjunction with customary maintenance. In addition, see instructions prepared by
the organisations.


  


					
	 Swedish Property Federation form no. 12B, prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels and
Restaurants Association (SHR). Copying prohibited.
 Notice: This is a translation into English of form no. 12B
 License number: 902745460-000058. Version 6.01. Registered to: Wihlborgs Fastigheter AB (publ.)
	 	Initial	 	Initial

  

 Page 4(4) 








  
 Bil 1 
  
 Här skall infogas relations ritningar 








			
	Wihlborgs	  	Appendix 2 to Lease Agreement No. 4811-20000

  
 The parties have agreed as follows
about reduction of the rent in conjunction with customary maintenance (an X in a box means that the text following thereafter applies). 
  

	 ̈	 	Reduction of the rent for obstacles to or infringement of the right of the user in consequence of the Landlord allowing work to be done in order to carry out customary
maintenance of the leased premises or the property is to be granted according to the rules of The Rent Act.  

  

	x	 	The Tenant is not entitled to reduction of the rent for obstacles to or infringement of the right of the user in consequence of the Landlord allowing work to be done in order to
carry out customary maintenance of the leased premises or the property. The Landlord shall, however, in good time inform the Tenant not only about the kind and the extent of the work but also about the starting point and the period during which the
work will be carried out.  

  

	 ̈	 	The parties are agreed that the right to reduction of the rent during the Landlord’s performance of customary maintenance of the leased premises or the property shall be
governed in accordance to the following.  


	


	    	 	                                      
                                        
                                        
                                        
                                

  

	    	 	                                      
                                        
                                        
                                        
                                

  

	    	 	                                      
                                        
                                        
                                        
                                

  

	    	 	                                      
                                        
                                        
                                        
                                

  

	    	 	                                      
                                        
                                        
                                        
                                

  

					
	 Place/date
	  	 	  	Place/date
			
	 Landlord
	  	 This is just a translation.
 Do not sign here!
 Sign the Swedish form!
	  	 
			
	 Printed name
	  	 	  	Printed name

  
  

 Swedish Property Federation form no. 12B, prepared in 1998 in consultation with the Swedish Federation of Trade and the Swedish Hotels and Restaurants
Association (SHR). Copying prohibited. 
 Notice: This is a translation into English of form no. 16 
 License number: 902745460-000058. Version 6.01. Registered to: Wihlborgs Fastigheter AB (publ.) 








					
	Wihlborgs	 	INDEX CLAUSE	 	 
	 	 	for non-residential premises	 	Appendix no. 3                

  

					
	Concerning	  	 Lease Agreement no
 4881-20000
	  	 Property designation
 Forskaren
1

		
	Landlord	  	 Medeon Fastigheter AB
 c/o Wihlborgs
Fastigheter AB

		
	Tenant	  	ACADIA Pharmaceuticals AB
		
	Clause	  	  
 Of the rent of SEK 7 400 000- stipulated in the
Lease Agreement 100 % or SEK 7 400 000:- shall constitute the base rent. During the period of the Lease Agreement, a surcharge to the rent, constituting a certain percentage of the base rent, shall be payable with regard to changes in
the consumer price index (using the total index for 1980 as a base) according to the following:



											
					
	 	  	 	  	 	  	–	  	For lease agreements commencing during the period 1/1—30/6 the base rent is deemed to be adjusted to the index level for that of the previous
October.
					
	 	  	 	  	 	  	–	  	for lease agreements commencing during the period 1/7—31/12 the base rent is deemed to be adjusted to the index level for October of that
year.
					
	 	  	 	  	 	  	–	  	The index level for the October that the base rent is deemed to be adjusted to, as shown above, becomes the base figure unless otherwise agreed by designating a year
as per the following. Alternative agreed base figure: the index level of October 2004.


					
		
	 	  	Should the index level any following October have risen in relation to the base figure, the surcharge shall be calculated on the percentage by which the index has changed in
relation to the base figure. Future surcharges due will be based on the changes in the index, the rental change to be calculated on the percentage change between the base figure and the index level for the October in question.
		
	 	  	The rent payable shall nevertheless be adjusted below that stipulated in the Lease Agreement. A change in the rent is always effective from 1st January following an
adjustment occasioned by a recomputation due to a change in the index the previous October.
		
	 	  	The instructions in page 2 are applicable to the agreement.


							
				
	Signature	  	Place/date	  	 	  	Place/date
				
	 	  	Landlord	  	 This is just a translation.
 Do not sign
here!
 Sign the Swedish form!
	  	Tenant


					
			
	 	  	 	  	  


			
	 	  	 	  	  


			
	 	  	 Printed name
  
  
	  	 Printed name
  
  


  
   The
Landlord’s notes regarding the base figure: 281,0 
  
  
  

 Swedish Property Federation form no. 6E,
prepared in 1999 in consultation with the Swedish Federation of Trade and the Swedish Hotels and Restaurants Association (SHR). Copying prohibited. 
 Notice: This is a translation into English of form no. 6E 
 License number: 902745460-000058. Version 6.01. Registered to: Wihlborgs
Fastigheter AB (publ.) 
  
  

 Page 1(2) 








 Instructions in respect of Index Clause for non-residential premises 
  
 Base Rent 
  
 Whether all or a part of the rent stipulated in the Lease Agreement shall consist of base rent, is a matter for negotiation and can depend
on the terms of the Lease Agreement (for example the quantum of the rent expressed as SEK/sq. m/per annum, and also for what other obligations the Tenant is responsible). 
  
 Base Figure 
  
 The index level for the October that the base rent is deemed to be aligned to becomes the base figure, unless otherwise agreed by designating a year (as per conditions
stated in page 1). 
  
 Comparison of index levels shall be done as soon as the
annual October index is published. During recent years the October index has been published by the middle of November. 
  
 Calculation of the Surcharge 
  

	1)	 	Calculate the difference between the relevant October index and the base figure. 

  

	2)	 	If the difference is positive, divide the difference by the base figure. 

  

	3)	 	The surcharge is calculated by multiplying the base rent by the factor thus determined. 

  
 Example 
  

	a)	 	Presume that the base rent is SEK 75,000 pa (per annum) and is aligned to the 1996 October index, which is 255.9. 1998 October index is 257.3. 

  

	 	1)	 	The difference between the index figure 257.3 and the case figure 255.9, is 1.4. 

  

	 	2)	 	1.4 divided by the base figure 255.9 produces a factor of 0.0055 (0.55%) 

  

	 	3)	 	This factor of 0.0055 (i.e. 0.55%) multiplied by the base rent SEK 75,000 is SEK 410 which according to the clause becomes the surcharge for 1999. 

  

	b)	 	Assume the base rent is instead aligned to the 1997 October index which is 259.6. 

  

	 	1)	 	The difference between the index level 257.3 and the base figure 259.6 is negative and no surcharge applies. The rent stated in the Lease Agreement applies.


  

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	Wihlborgs	 	PROPERTY TAX CLAUSE	 	 
	 	for non-residential premises	 	Appendix no. 5                

  

							
	Part of	  	 Lease Agreement no.
 4881-20000
	  	 Property designation
 Forskaren
1

	Landlord	  	Medeon Fastigheter AB
	 	  	c/o Wihlborgs Fastigheter AB
		
	Tenant	  	ACADIA Pharmaceuticals AB
		
	Clause	  	The applicable alternative is indicated by putting an X in the relevant box and completing the requisite details.
		
	 	  	To the extent that the parts of the property that are comprised of non-residential premises are or become subject to property tax, the Tenant shall with the rent reimburse the
Landlord according to the conditions as indicated below.
		
	 	  	 x     The Tenant shall
in addition to the rent specified in the Lease Agreement annually reimburse the Landlord for his share of property tax due in respect of the non-residential premises. The Tenant’s share is deemed to be 100 per cent.
           According to the conditions that apply at the inception of the
Lease Agreement the reimbursement at the inception of the rental period is SEK ej kant a year.

		
	 	  	  ̈      Reimbursement in respect of the current share of property tax for the non-residential premises is included in the rent specified in the Lease Agreement and at its inception it is
SEK

		
	 	  	           The non-residential premises share of the property tax applying
to non-residential premises is deemed to be              per cent. The Tenant shall provide reimbursement for his share of any changes in the applicable property tax in respect of
non-residential premises that take effect after the inception of the Lease Agreement (irrespective of the cause) to the extent that the tax exceeds that amount that is included in the rent as reimbursement for property tax.

		
	 	  	           Should the property tax reduce/cease so that Tenant’s share
of the reimbursement is less than that as per above, which is included in the rent specified in the Lease Agreement, the rent shall nevertheless be payable at not less than the original amount. Thus due to other clauses (e.g. index) contained in the
agreement this means that the total rent payable by the Tenant is/can be greater than that shown in the Lease Agreement.

		
	 	  	The Tenant’s above specified share, which shall be unchanged during the term of the Lease Agreement, has been calculated as follows:
	 	  	  

  

  


		
	 	  	The instructions in page 2 are applicable to the agreement.
				
	Signature	  	Place/date	  	 	  	Place/date
				
	 	  	Landlord 	  	 This is just a translation.
 Do not
sign here!
 Sign the Swedish form!
	  	Tenant
	 	  	 	  	 	  	 
	 	  	 	  	 	  	 
	 	  	Printed name	  	 	  	Printed name

  

 Swedish Property Federation. Form no. 7B, prepared in 1995. Item 2 in the instructions was revised in 1997. Copying prohibited. 
 Notice: This is a translation into English of form no. 7B 
 License number: 902745460-000058. Version 6.01.
Registered to: Wihlborgs Fastigheter AB (publ.) 
  

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 Instructions – Property tax clause for non-residential premises 
  
 1. The clause was formulated in June 1995, i.e., before the time (normally the
1st of January 1995) from which property tax for premises applies. Therefore the clause has a wording which means
that it can be incorporated in agreements that have been made before the tax is payable, as well as in agreements where the tax is actually payable. 
  
 2. The reimbursement shall compensate for the increased costs of administration irrespective of who is liable for the tax. A property owner/Landlord is liable for
tax. According to previous regulations if the property owner/Landlord was a trading partnership the owners/shareholders were liable for tax. The supplement was nevertheless to be paid to the Landlord as a matter of course. After the 1st of January 1997 trading partnerships as such (and not the individual owners/shareholders) are liable for property tax.

  
 3. According to section 19 of the Rent Act the rent must – with
some exceptions – be determined in the Lease Agreement. If the rental period is fixed, and is for at least three years, certain additional exceptions apply in that the rent shall be payable with such sums which are determined according to
“different method of calculation” e.g. indexation. This also means that the rental period has to be fixed and be at least three years to enable the Landlord to obtain reimbursement for property tax in sums that can vary as the tax changes.
Furthermore the method of calculation must be shown in the Lease Agreement. The clause therefore presumes that the parties state what share of the tax the Tenant shall provide reimbursement for. 
  
 According to the regulations that apply when this clause is formulated the tax is comprised
of a certain percentage of the assessed value of the premises (both grounds and buildings). This information is to be found in the tax statement. The Tenant’s share of the tax for the premises can be determined by the relationship which the
extent of that area leased by the Tenant bears to the total lettable premises in the property or as a relationship between the Tenant’s rent and the total of the rents for premises in the property. 
  
 It is a matter for negotiation which method of calculation the parties choose. Other methods
of calculation can be used. For the sake of simplicity, however, the Tenant’s share should be unchanged during the rental period, and thereby independent of among other things, how the tax in the future might be calculated and possible changes
in the rental market. 
  
 It is therefore appropriate to show in the designated
space how the premises share has been calculated. Should details in respect of this not be completed this does not mean that the agreement becomes invalid. A property can comprise of a variety of different buildings with different value years and
different taxation categories (small dwelling houses, apartment blocks, industrial units and special units). The tax – that the Tenant is due to pay reimbursement for – shall only relate to the building in which the premises are located. A
building is normally defined as a free standing self-contained building. Relevant information can be ascertained from information regarding decisions referring to general property taxation that the tax authorities have advised the property owner.
Any property owner who has a problem in ascertaining the Tenant’s share should contact their property owners association for assistance. 
  
 Complete the Tenant’s share! 
  
 4. The clause contains two alternatives. In the first the reimbursement for the tax is payable as a supplement “alongside” the rent agreed in the Lease
Agreement. If the tax disappears so does the supplement. The other alternative presumes that the parties agree a specific rent which includes, among other things, reimbursement for the then applicable tax. Should the tax be increased irrespective of
the cause (for example increase in tax rates, increased assessed value etc) the Tenant shall nevertheless tender reimbursement for the increased cost. Should the tax disappear the rent reverts to the original sum, i.e., the agreed rent (which
includes reimbursement for the tax applicable at inception which has been discontinued). Naturally the Tenant shall continue to pay other supplements such as those caused by changes in indexes and in respect of increased fuel costs and so forth.

  
 5. To the extent that the Tenant pays a supplement in respect of
property tax the supplement should be accounted for separately on the rent invoice. 
  
 6. Indicate the chosen alternative with an X. In the chosen alternative the Tenant’s share and the sum should be filled in. Specify how the Tenant’s share has been calculated. 
  

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 Appendix 7 
  

Special Provisions 
  

	1	 	Condition of the Premises 

  

	1.1	 	The premises are let in the condition set forth in the General Agreement entered into between the Landlord and the Tenant and shall be used as office and laboratory within the frame
of the Tenant’s enterprise. 

  

	2	 	Extension of term of lease 

  

	2.1	 	The Tenant shall have the right to extend the term of lease with an additional period of five (5) years from the expiration of the initial ten (10) year-term, on in all other
respects unaltered terms and conditions. 

  

	2.2	 	Should the Tenant not exercise its right of extension, the Tenant shall – in addition to the ordinary remaining rental payments – pay a penalty to the Landlord with an
amount corresponding to the annual rent of year ten of the initial ten year-term. 

  

	3	 	Early termination 

  

	3.1	 	The Tenant is entitled to terminate this Lease Agreement by giving notice twelve (12) months in advance. 

  

	3.2	 	Should the Tenant exercise its right of early termination set forth in 3.1 above, the Tenant shall pay to the Landlord compensation with an amount corresponding to two thirds (2/3)
of the total amount of all future rental payments. 

  

	3.3	 	The compensation for the period 2005-06-01 – 2007-05-31 shall amount to maximum SEK 40,000,000 (forty million) and for the period 2007-06-01 – 2015-05-31 to maximum SEK
35,000,000 (thirty five million). 

  

	3.4	 	The obligation for the Tenant to compensate the landlord shall under no circumstances be less than an amount corresponding to the annual rent for two (2) years.


  

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	4	 	Subletting 

  

	4.1	 	The Tenant may sublet the premises, in whole or partly, provided that the Landlord reasonably should be content with the new sub-tenant and provided that the subletting entails a
liability to pay value-added tax. 

  

	4.2	 	Subletting is permitted under the prerequisite that the Tenant has the full responsibility for any and all obligations under this Lease Agreement. 

  

	5	 	Use of the premises 

  

	5.1	 	The Tenant is solely responsible for the observation of applicable law and regulation as regards use of the premises. The Tenant shall indemnify the Landlord for any losses relating
to the Tenant’s omission to fulfill his liability set forth in this section. 

  

	6	 	English translation 

  

	6.1	 	An English translation of the lease Agreement with appendices has been enclosed to the agreement, Appendix 8. Should any dispute arise regarding the interpretation of this
Lease Agreement, the parties have agreed that the Swedish version of this Lease Agreement with appendices shall precede. 

  

  

			
	 Place:
	  	Place:
		
	 Date:
	  	Date:
		
	 MEDEON FASTIGHETER AB
	  	ACADIA PHARMACEUTICALS AB

  
 [This is just a
translation. Do not sign here!] 
  

			
	
	 	


  

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