68456 Federal Register / Vol. 79, No. 221 / Monday, November 17, 2014 / Notices 

Inventors: Jake Tsanyang Liang 

(NIDDK), Zongyi Hu (NIDDK), Juan Jose 

Marugan (NCATS), Noel Terrance 

Southhall (NCATS), Xin Hu (NCATS), 

Jingbo Xiao (NCATS), Shanshan He 

(NIDDK), Marc Ferrer-Alegre (NCATS), 

Wei Zhang (NCATS) 

Intellectual Property: HHS Reference 

No. E–161–2014/0—U.S. Provisional 

Patent Application No. 62/011,462 filed 

12 June2014 

Licensing Contact: Kevin W. Chang, 

Ph.D.; 301–435–5018; changke@

mail.nih.gov 

Autodock Vina Software Process for 

Efficient Large-Scale Cognate Ligand 

Screening 

Description of Technology: The 

invention pertains to software 

processes, additions, and docking 

approaches to Autodock Vina that 

speeds the rate and efficiency of 

analyzing ligand interactions with a 

receptor by cognate ligands and rewards 

conformations in the scoring algorithm 

for residue interactions that are based 

on the biological data. The score is 

multiplied by a weighting factor to 

control the degree of ligand-residue 

interactions that are considered. This 

multiplier is then added to the docking 

score for confirmation. This new scoring 

mechanism is used to score each 

compound in each generation of the 

evolutionary genetic algorithm. This 

docking approach can be used to score 

and rank compounds in large-scale 

virtual screening applications. The 

software includes logic for converting 

SDF formatted to an Autodock Vina 

compatible format (containing approx. 

25,000 compounds each) and submits 

the job to the portable batch system on 

the computing cluster to convert into 

PDBC files (a concatenated filed type). 

Modified Vina software stores the 

analyzed binding pocket in RAM that 

does not have to be recomputed upon 

every docking process. This increases 

the efficiency of the docking algorithm 

by several orders of magnitude. The 

software on the head node intelligently 

monitors memory usage, CPU usage and 

docking speed. Based on this 

information, the head node elastically 

controls the load on each node. 

Potential Commercial Applications: 

• Drug screening. 

• Ligand identification. 

Competitive Advantages: 

• Speed. 

• Batch processing. 

• Efficient CPU processing. 

Development Stage: In vitro data 

available. 

Inventors: Marvin Gershengorn, 

Umesh Padia, Janak Padia, Elizabeth 

Geras-Raaka (all of NIDDK). 

Intellectual Property: HHS Reference 

No. E–289–2014/0—Software Tool. 

Patent protection is not being pursued 

for this technology. 

Licensing Contact: Michael 

Shmilovich, Esq.; 301–435–5019; 

shmilovm@mail.nih.gov. 

Collaborative Research Opportunity: 

The National Institutes of Diabetes and 

Digestive and Kidney Diseases is 

seeking statements of capability or 

interest from parties interested in 

collaborative research to further 

develop, evaluate or commercialize 

Cognate Ligand Identification. For 

collaboration opportunities, please 

contact Anna Amar at 301–451–2305 or 

aamar@mail.nih.gov. 

Dated: November 10, 2014. 

Richard U. Rodriguez, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. 2014–27083 Filed 11–14–14; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Mental Health: 

Notice of Closed Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Mental Health Special Emphasis Panel; 

NIMH Career Transition Award for TenureTrack and Tenured Intramural Investigators 

(K22). 

Date: December 2, 2014. 

Time: 12:30 p.m. to 1:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health 

Neuroscience Center, 6001 Executive 

Boulevard, Rockville, MD 20852 (Telephone 

Conference Call). 

Contact Person: Ingrid Y. Li, Ph.D., Health 

Science Administrator Division of 

Extramural Activities, National Institute of 

Mental Health, NIH Neuroscience Center, 

6001 Executive Blvd., Room 6154–C, 

Bethesda, MD 20892, 301–443–1421, 

ili1@mail.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program No. 93.242, Mental Health Research 

Grants, National Institutes of Health, HHS) 

Dated: November 7, 2014. 

Carolyn A. Baum, 

Program Analyst, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2014–27060 Filed 11–14–14; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Environmental 

Health Sciences; Notice of Closed 

Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The contract proposals and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the contract 

proposals, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Environmental Health Sciences Special 

Emphasis Panel; Alternative Toxicological 

Methods Support Contract for the National 

Toxicology Program (NTP). 

Date: December 11, 2014. 

Time: 1:00 p.m. to 5:00 p.m. 

Agenda: To review and evaluate contract 

proposals. 

Place: National Institute of Environmental 

Health Sciences, Keystone Building, 

Conference Room 2166, 530 Davis Drive, 

Research Triangle Park, NC 27709, 

(Telephone Conference Call). 

Contact Person: RoseAnne M. McGee, 

Scientific Review Officer, Scientific Review 

Branch, Division of Extramural Research and 

Training, Nat. Institute of Environmental 

Health Sciences, P.O. Box 12233, MD EC–30, 

Research Triangle Park, NC 27709 (919) 541– 

0752, mcgee1@niehs.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.115, Biometry and Risk 

Estimation—Health Risks from 

Environmental Exposures; 93.142, NIEHS 

Hazardous Waste Worker Health and Safety 

Training; 93.143, NIEHS Superfund 

Hazardous Substances—Basic Research and 

Education; 93.894, Resources and Manpower 

Development in the Environmental Health 

Sciences; 93.113, Biological Response to 

Environmental Health Hazards; 93.114, 


asabaliauskas on DSK5VPTVN1PROD with NOTICES
Federal Register / Vol. 79, No. 221 / Monday, November 17, 2014 / Notices 68457 

1PPD–21 can be found at: http://

www.whitehouse.gov/the-press-office/2013/02/12/

presidential-policy-directive-critical-infrastructuresecurity-and-resil. 

Applied Toxicological Research and Testing, 

National Institutes of Health, HHS) 

Dated: November 7, 2014. 

Carolyn Baum, 

Program Analyst, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2014–27059 Filed 11–14–14; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Allergy and 

Infectious Diseases: Notice of Closed 

Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meetings. 

The meetings will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Allergy and Infectious Diseases Special 

Emphasis Panel Modeling Immunity for 

Biodefense (U19). 

Date: December 8–10, 2014. 

Time: 8:00 a.m. to 6:00 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Sheraton—Silver Spring, Magnolia 

Ballroom, 8777 Georgia Avenue Silver 

Spring, MD 20910. 

Contact Person: Quirijn Vos, Ph.D., 

Scientific Review Officer, Scientific Review 

Program, Division of Extramural Activities, 

DHHS/NIH/NIAID, 6700B Rockledge Drive, 

MSC 7616, Bethesda, MD 20892, 301–451– 

2666, qvos@niaid.nih.gov. 

Name of Committee: National Institute of 

Allergy and Infectious Diseases Special 

Emphasis Panel Beyond HAART: Innovative 

Approaches to Cure HIV–1 (U19). 

Date: December 10–12, 2014. 

Time: 8:00 a.m. to 5:00 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Hyatt Regency Bethesda, Baccarat 

Suite, One Bethesda Metro Center, Bethesda, 

MD 20814. 

Contact Person: Betty Poon, Ph.D., 

Scientific Review Officer, Scientific Review 

Program Division of Extramural Activities, 

NIAID/NIH/DHHS, 6700B Rockledge Drive, 

MSC 7616, Bethesda, MD 20892–7616, 301– 

402–6891, poonb@mail.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.855, Allergy, Immunology, 

and Transplantation Research; 93.856, 

Microbiology and Infectious Diseases 

Research, National Institutes of Health, HHS) 

Dated: November 7, 2014. 

David Clary, 

Program Analyst, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2014–27058 Filed 11–14–14; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HOMELAND 

SECURITY 

[Docket No. DHS–2013–0074] 

Request for Comments and Answers 

to Specific Questions To Inform 

Development of the National Critical 

Infrastructure Security and Resilience 

(NCISR) Research and Development 

(R&D) Plan 

AGENCY: Science and Technology 

Directorate, DHS. 

ACTION: Notice and Request for 

Comments and Answers to Specific 

Questions. 

SUMMARY: This Notice requests general 

comments and answers to specific 

questions to inform development of the 

National Critical Infrastructure Security 

and Resilience Research and 

Development Plan (NCISR R&D Plan) 

called for in Presidential Policy 

Directive (PPD) 21, Critical 

Infrastructure Security and Resilience. 

As part of a comprehensive national 

review process, the Department of 

Homeland Security (DHS) is soliciting 

public comments to support the DHS 

Science and Technology Directorate 

(S&T) in writing the NCISR R&D Plan. 

Critical infrastructure includes cyber 

and physical assets, systems, and 

networks comprising the 16 critical 

infrastructure sectors identified in PPD– 

21. 

DATES: Written comments are 

encouraged and will be accepted until 

December 17, 2014. 

ADDRESSES: You may submit comments, 

identified by docket number DHS– 

2013–0074, by any of the following 

methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the 

instructions for submitting comments. 

• Email: R&DWG@hq.dhs.gov. 

Include the docket number DHS–2013– 

0074 in the subject line of the message. 

• Mail: Kristin Wyckoff, DHS/S&T/

RSD, 445 Murray Lane SW., Mail Stop 

0208, Washington, DC 20528–0208. 

Docket: For access to the docket to 

read background documents or 

comments received, go to http://

www.regulations.gov. For more 

information on submitting written 

comments, see the SUPPLEMENTARY

INFORMATION section below. 

FOR FURTHER INFORMATION CONTACT: 

Kristin Wyckoff, DHS/S&T/RSD, 445 

Murray Lane SW., Mail Stop 0208, 

Washington, DC 20528–0208. 

SUPPLEMENTARY INFORMATION: 

I. Public Participation 

DHS invites interested persons to 

provide input and answers to specific 

questions to inform the identification of 

national R&D priorities for the NCISR 

R&D Plan. Input is welcome from 

stakeholder groups, private and public 

entities, and individuals on content to 

be included to best fulfill the intended 

purpose of the plan. Comments that will 

provide the most assistance to DHS will 

include a rationale for the stated answer 

or recommendation, along with 

supplemental data, information, or 

authority that supports the response. 

II. Additional Instructions for Written 

Submissions 

All written submissions must include 

the words ‘‘Department of Homeland 

Security’’ and the docket number for 

this action. All comments received (via 

any of the identified methods) will be 

posted without change to http://

www.regulations.gov, including any 

personal information provided. Please 

submit your comments and material by 

only one means to avoid the posting of 

duplicate submissions. 

If you submit comments by mail, your 

submission should be an unbound 

document and no larger than 8.5 by 11 

inches to enable copying and electronic 

document management. Please limit 

submissions to a maximum of ten pages 

of text if possible. If you want DHS to 

acknowledge receipt of comments by 

mail, include with your comments a 

self-addressed, stamped postcard that 

includes the docket number for this 

action. DHS will date your postcard and 

return it to you via regular mail. 

III. Background 

On February 12, 2013, President 

Obama signed PPD–21,1 Critical 

Infrastructure Security and Resilience, 

which builds on the extensive work 

done to date to protect and enhance the 

resilience of the Nation’s critical 

infrastructure. This directive aims to 

clarify roles and responsibilities across 

the Federal Government and establish a 

more effective partnership with owners 


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