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Exhibit 10.1    
    


THERAVANCE, INC.  


 
 

1997 STOCK PLAN
  
  
  ADOPTED ON JUNE 23, 1997    
    







 
 
 

TABLE OF CONTENTS    
    



	 
	 	 
	 	Page No.

	

SECTION 1.    ESTABLISHMENT AND PURPOSE	
 	

1
	

SECTION 2.    ADMINISTRATION	
 	

1
	

(a)	
 	

Committees of the Board of Directors	
 	

1
	(b)	 	Authority of the Board of Directors	 	1
	

SECTION 3.    ELIGIBILITY	
 	

1
	

(a)	
 	

General Rule	
 	

1
	(b)	 	Ten-Percent Stockholders	 	1
	

SECTION 4.    STOCK SUBJECT TO PLAN	
 	

1
	

(a)	
 	

Basic Limitation	
 	

1
	(b)	 	Additional Shares	 	2
	

SECTION 5.    TERMS AND CONDITIONS OF AWARDS OR SALES	
 	

2
	

(a)	
 	

Stock Purchase Agreement	
 	

2
	(b)	 	Duration of Offers and Nontransferability of Rights	 	2
	(c)	 	Purchase Price	 	2
	(d)	 	Withholding Taxes	 	2
	(e)	 	Restrictions on Transfer of Shares and Minimum Vesting	 	2
	(f)	 	Accelerated Vesting	 	2
	

SECTION 6.    TERMS AND CONDITIONS OF OPTIONS	
 	

3
	

(a)	
 	

Stock Option Agreement	
 	

3
	(b)	 	Number of Shares	 	3
	(c)	 	Exercise Price	 	3
	(d)	 	Withholding Taxes	 	3
	(e)	 	Exercisability	 	3
	(f)	 	Accelerated Exercisability	 	3
	(g)	 	Basic Term	 	3
	(h)	 	Nontransferability	 	3
	(i)	 	Termination of Service (Except by Death)	 	4
	(j)	 	Leaves of Absence	 	4
	(k)	 	Death of Optionee	 	4
	(l)	 	No Rights as a Stockholder	 	4
	(m)	 	Modification, Extension and Assumption of Options	 	5
	(n)	 	Restrictions on Transfer of Shares and Minimum Vesting	 	5
	(o)	 	Accelerated Vesting	 	5
	 	 	 	 	 





i







 


	

SECTION 7.    PAYMENT FOR SHARES	
 	

5
	

(a)	
 	

General Rule	
 	

5
	(b)	 	Surrender of Stock	 	5
	(c)	 	Services Rendered	 	5
	(d)	 	Promissory Note	 	5
	(e)	 	Exercise/Sale	 	6
	(f)	 	Exercise/Pledge	 	6
	

SECTION 8.    ADJUSTMENT OF SHARES	
 	

6
	

(a)	
 	

General	
 	

6
	(b)	 	Mergers and Consolidations	 	6
	(c)	 	Reservation of Rights	 	6
	

SECTION 9.    SECURITIES LAWS REQUIREMENTS	
 	

7
	

(a)	
 	

General	
 	

7
	(b)	 	Financial Reports	 	7
	

SECTION 10.    NO RETENTION RIGHTS	
 	

7
	

SECTION 11.    DURATION AND AMENDMENTS	
 	

7
	

(a)	
 	

Term of the Plan	
 	

7
	(b)	 	Right to Amend or Terminate the Plan	 	7
	(c)	 	Effect of Amendment or Termination	 	7
	

SECTION 12.    DEFINITIONS	
 	

7




ii








  



 
 

THERAVANCE, INC. 1997 STOCK PLAN    
    


 
 

SECTION 1.    ESTABLISHMENT AND PURPOSE.    
    


        The purpose of the Plan is to offer selected individuals an opportunity to acquire a proprietary interest in the success of the Company, or to increase such
interest, by purchasing Shares of the Company's Stock. The Plan provides both for the direct award or sale of Shares and for the grant of Options to purchase Shares. Options granted under the Plan may
include Nonstatutory Options as well as ISOs intended to qualify under Section 422 of the Code. 


        Capitalized
terms are defined in Section 12. 


 
 

SECTION 2.    ADMINISTRATION.    
    



        (a)   Committees of the Board of Directors.    The Plan may be administered by one or more Committees. Each Committee
shall consist of one or more members of the Board of Directors who have been appointed by the Board of Directors. Each Committee shall have such authority and be responsible for such functions as the
Board of Directors has assigned to it. If no Committee has been appointed, the entire Board of Directors shall administer the Plan. Any reference to the Board of Directors in the Plan shall be
construed as a reference to the Committee (if any) to whom the Board of Directors has assigned a particular function. 



        (b)   Authority of the Board of Directors.    Subject to the provisions of the Plan, the Board of Directors shall
have full authority and discretion to take any actions it deems necessary or advisable for the administration of the Plan. All decisions, interpretations and other actions of the Board of Directors
shall be final and binding on all Purchasers, all Optionees and all persons deriving their rights from a Purchaser or Optionee. 


 
 

SECTION 3.    ELIGIBILITY.    




        (a)   General Rule.    Only Employees, Outside Directors and Consultants shall be eligible for the grant of Options
or the direct award or sale of Shares. Only Employees shall be eligible for the grant of ISOs. 


        (b)   Ten-Percent Stockholders.    An individual who owns more than 10% of the total combined voting
power of all classes of outstanding stock of the Company, its Parent or any of its Subsidiaries shall not be eligible for designation as an Optionee or Purchaser unless (i) the Exercise Price
is at least 110% of the Fair Market Value of a Share on the date of grant, (ii) the Purchase Price (if any) is at least 100% of the Fair Market Value of a Share and (iii) in the case of
an ISO, such ISO by its terms is not exercisable after the expiration of five years from the date of grant. For purposes of this Subsection (b), in determining stock ownership, the attribution rules
of Section 424(d) of the Code shall be applied. 


 
 

SECTION 4.    STOCK SUBJECT TO PLAN.    
    



        (a)   Basic Limitation.    Shares offered under the Plan may be authorized but unissued Shares or treasury Shares.
The aggregate number of Shares that may be issued under the Plan (upon exercise of Options or other rights to acquire Shares) shall not exceed 18,641,3951 Shares, subject to adjustment
pursuant to Section 8. The number of Shares that are subject to Options or other rights outstanding at any time under the Plan shall not exceed the number of Shares that then remain available
for issuance under the Plan. The Company, during the term of the Plan, shall at all times reserve and keep available sufficient Shares to satisfy the requirements of the Plan. 




	1
	Includes
all share increases authorized by the Board of Directors through April 28, 2004 and approved by the stockholders through January 15, 2003. 


1







 

        (b)   Additional Shares.    In the event that any outstanding Option or other right for any reason expires or is
canceled or otherwise terminated, the Shares allocable to the unexercised portion of such Option or other right shall again be available for the purposes of the Plan. In the event that Shares issued
under the Plan are reacquired by the Company pursuant to any forfeiture provision, right of repurchase or right of first refusal, such Shares shall again be available for the purposes of the Plan,
except that the aggregate number of Shares which may be issued upon the exercise of ISOs shall in no event exceed 18,641,395 Shares (subject to adjustment pursuant to Section 8). 


 
 

SECTION 5.    TERMS AND CONDITIONS OF AWARDS OR SALES.    
    



        (a)   Stock Purchase Agreement.    Each award or sale of Shares under the Plan (other than upon exercise of an
Option) shall be evidenced by a Stock Purchase Agreement between the Purchaser and the Company. Such award or sale shall be subject to all applicable terms and conditions of the Plan and may be
subject to any other terms and conditions which are not inconsistent with the Plan and which the Board of Directors deems appropriate for inclusion in a Stock Purchase Agreement. The provisions of the
various Stock Purchase Agreements entered into under the Plan need not be identical. 



        (b)   Duration of Offers and Nontransferability of Rights.    Any right to acquire Shares under the Plan (other than
an Option) shall automatically expire if not exercised by the Purchaser within 30 days after the grant of such right was communicated to the Purchaser by the Company. Such right shall not be
transferable and shall be exercisable only by the Purchaser to whom such right was granted. 


        (c)   Purchase Price.    The Purchase Price of Shares to be offered under the Plan shall not be less than 85% of the
Fair Market Value of such Shares, and a higher percentage may be required by Section 3(b). Subject to the preceding sentence, the Purchase Price shall be determined by the Board of Directors at
its sole discretion. The Purchase Price shall be payable in a form described in Section 7. 


        (d)   Withholding Taxes.    As a condition to the purchase of Shares, the Purchaser shall make such arrangements as
the Board of Directors may require for the satisfaction of any federal, state, local or foreign withholding tax obligations that may arise in connection with such purchase. 



        (e)   Restrictions on Transfer of Shares and Minimum Vesting.    Any Shares awarded or sold under the Plan shall be
subject to such special forfeiture conditions, rights of repurchase, rights of first refusal and other transfer restrictions as the Board of Directors may determine. Such restrictions shall be set
forth in the applicable Stock Purchase Agreement and shall apply in addition to any restrictions that may apply to holders of Shares generally. In the case of a Purchaser who is not an officer of the
Company, an Outside Director or a Consultant, any right to repurchase the Purchaser's Shares at the original Purchase Price (if any) upon termination of the Purchaser's Service shall lapse at least as
rapidly as 20% per year over the five-year period commencing on the date of the award or sale of the Shares. Any such right may be exercised only within 90 days after the
termination of the Purchaser's Service for cash or for cancellation of indebtedness incurred in purchasing the Shares. 


        (f)    Accelerated Vesting.    Unless the applicable Stock Purchase Agreement provides otherwise, any right to
repurchase a Purchaser's Shares at the original Purchase Price (if any) upon termination of the Purchaser's Service shall lapse and all of such Shares shall become vested if (i) the Company is
subject to a Change in Control before the Purchaser's Service terminates and (ii) the repurchase right is not assigned to the entity that employs the Purchaser immediately after the Change in
Control or to its parent or subsidiary. Notwithstanding the foregoing, in the event that (i) there is an Involuntary Termination within twelve months after a Change in Control and
(ii) the repurchase right had been assigned to the entity that employs the Purchaser immediately after the Change in Control or to its parent or subsidiary, then the repurchase right shall
lapse and an additional number of the Purchaser's Shares shall vest, as if the Purchaser performed Service for an additional twelve months. 


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SECTION 6.    TERMS AND CONDITIONS OF OPTIONS.    
    


        (a)   Stock Option Agreement.    Each grant of an Option under the Plan shall be evidenced by a Stock Option
Agreement between the Optionee and the Company. Such Option shall be subject to all applicable terms and conditions of the Plan and may be subject to any other terms and conditions which are not
inconsistent with the Plan and which the Board of Directors deems appropriate for inclusion in a Stock Option Agreement. The provisions of the various Stock Option Agreements entered into under the
Plan need not be identical. 


        (b)   Number of Shares.    Each Stock Option Agreement shall specify the number of Shares that are subject to the
Option and shall provide for the adjustment of such number in accordance with Section 8. The Stock Option Agreement shall also specify whether the Option is an ISO or a Nonstatutory Option. 


        (c)   Exercise Price.    Each Stock Option Agreement shall specify the Exercise Price. The Exercise Price of an ISO
shall not be less than 100% of the Fair Market Value of a Share on the date of grant, and a higher percentage may be required by Section 3(b). The Exercise Price of a Nonstatutory Option shall
not be less than 85% of the Fair Market Value of a Share on the date of grant, and a higher percentage may be required by Section 3(b). Subject to the preceding two sentences, the Exercise
Price under any Option shall be determined by the Board of Directors at its sole discretion. The Exercise Price shall be payable in a form described in Section 7. 


        (d)   Withholding Taxes.    As a condition to the exercise of an Option, the Optionee shall make such arrangements as
the Board of Directors may require for the satisfaction of any federal, state, local or foreign withholding tax obligations that may arise in connection with such exercise. The Optionee shall also
make such arrangements as the Board of Directors may require for the satisfaction of any federal, state, local or foreign withholding tax obligations that may arise in connection with the disposition
of Shares acquired by exercising an Option. 


        (e)   Exercisability.    Each Stock Option Agreement shall specify the date when all or any installment of the Option
is to become exercisable. In the case of an Optionee who is not an officer of the Company, an Outside Director or a Consultant, an Option shall become exercisable at least as rapidly as 20% per year
over the five-year period commencing on the date of grant. Subject to the preceding sentence, the exercisability provisions of any Stock Option Agreement shall be determined by the Board
of Directors at its sole discretion. 


        (f)    Accelerated Exercisability.    Unless the applicable Stock Option Agreement provides otherwise, all of an
Optionee's Options shall become exercisable in full if (i) the Company is subject to a Change in Control before the Optionee's Service terminates, (ii) such Options do not remain
outstanding, (iii) such Options are not assumed by the surviving corporation or its parent and (iv) the surviving corporation or its parent does not substitute options with substantially
the same terms for such Options. Notwithstanding the foregoing, in the event that (i) there is an Involuntary Termination within twelve months after a Change in Control and (ii) the
Options had been assumed or substituted by the surviving corporation or its parent, then the repurchase right with respect to the Options shall lapse and an additional number of Shares subject to the
Optionee's Options shall become exercisable and vest, as if the Optionee performed Service for an additional twelve months. 


        (g)   Basic Term.    The Stock Option Agreement shall specify the term of the Option. The term shall not exceed
10 years from the date of grant, and a shorter term may be required by Section 3(b). Subject to the preceding sentence, the Board of Directors at its sole discretion shall determine when
an Option is to expire. 


        (h)   Nontransferability.    No Option shall be transferable by the Optionee other than by beneficiary designation,
will or the laws of descent and distribution. An Option may be exercised during 


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the
lifetime of the Optionee only by the Optionee or by the Optionee's guardian or legal representative. No Option or interest therein may be transferred, assigned, pledged or hypothecated by the
Optionee during the Optionee's lifetime, whether by operation of law or otherwise, or be made subject to execution, attachment or similar process. 


        (i)    Termination of Service (Except by Death).    If an Optionee's Service terminates for any reason other than the
Optionee's death, then the Optionee's Options shall expire on the earliest of the following occasions, unless the periods of time for which the Options remain exercisable are otherwise extended by the
Board of Directors or Committee: 



        (i)    The
expiration date determined pursuant to Subsection (g) above; 


        (ii)   The
date three months after the termination of the Optionee's Service for any reason other than Disability; or 


        (iii)  The
date six months after the termination of the Optionee's Service by reason of Disability. 




The
Optionee may exercise all or part of the Optionee's Options at any time before the expiration of such Options under the preceding sentence, but only to the extent that such Options had become
exercisable before the Optionee's Service terminated (or became exercisable as a result of the termination) and the underlying Shares had vested before the Optionee's Service terminated (or vested as
a result of the termination). The balance of such Options shall lapse when the Optionee's Service terminates. In the event that the Optionee dies after the termination of the Optionee's Service but
before the expiration of the Optionee's Options, all or part of such Options may be exercised (prior to expiration) by the executors or administrators of the Optionee's estate or by any person who has
acquired such Options directly from the Optionee by beneficiary designation, bequest or inheritance, but only to the extent that such Options had become exercisable before the Optionee's Service
terminated (or became exercisable as a result of the termination) and the underlying Shares had vested before the Optionee's Service terminated (or vested as a result of the termination). 


        (j)    Leaves of Absence.    For purposes of Subsection (i) above, Service shall be deemed to continue while
the Optionee is on a bona fide leave of absence, if such leave was approved by the Company in writing and if continued crediting of Service for this purpose is expressly required by the terms of such
leave or by applicable law (as determined by the Company). 


        (k)   Death of Optionee.    If an Optionee dies while the Optionee is in Service, then the Optionee's Options shall
expire on the earlier of the following dates, unless the periods of time for which the Options remain exercisable are otherwise extended by the Board of Directors or Committee: 



        (i)    The
expiration date determined pursuant to Subsection (g) above; or 


        (ii)   The
date 12 months after the Optionee's death. 




All
or part of the Optionee's Options may be exercised at any time before the expiration of such Options under the preceding sentence by the executors or administrators of the Optionee's estate or by
any person who has acquired such Options directly from the Optionee by beneficiary designation, bequest or inheritance, but only to the extent that such Options had become exercisable before the
Optionee's death or became exercisable as a result of the death. The balance of such Options shall lapse when the Optionee dies. 


        (l)    No Rights as a Stockholder.    An Optionee, or a transferee of an Optionee, shall have no rights as a
stockholder with respect to any Shares covered by the Optionee's Option until such person becomes entitled to receive such Shares by filing a notice of exercise and paying the Exercise Price pursuant
to the terms of such Option. 


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        (m)  Modification, Extension and Assumption of Options.    Within the limitations of the Plan, the Board of
Directors may modify, extend or assume outstanding Options or may accept the cancellation of outstanding Options (whether granted by the Company or another issuer) in return for the grant of new
Options for the same or a different number of Shares and at the same or a different Exercise Price. The foregoing notwithstanding, no modification of an Option shall, without the consent of the
Optionee, impair the Optionee's rights or increase the Optionee's obligations under such Option. 


        (n)   Restrictions on Transfer of Shares and Minimum Vesting.    Any Shares issued upon exercise of an Option shall
be subject to such special forfeiture conditions, rights of repurchase, rights of first refusal and other transfer restrictions as the Board of Directors may determine. Such restrictions shall be set
forth in the applicable Stock Option Agreement and shall apply in addition to any restrictions that may apply to holders of Shares generally. In the case of an Optionee who is not an officer of the
Company, an Outside Director or a Consultant, any right to repurchase the Optionee's Shares at the original Exercise Price upon termination of the Optionee's Service shall lapse at least as rapidly as
20% per year over the five-year period commencing on the date of the option grant. Any such repurchase right may be exercised only within 90 days after the termination of the
Optionee's Service for cash or for cancellation of indebtedness incurred in purchasing the Shares. 


        (o)   Accelerated Vesting.    Unless the applicable Stock Option Agreement provides otherwise, any right to
repurchase an Optionee's Shares at the original Exercise Price upon termination of the Optionee's Service shall lapse and all of such Shares shall become vested if (i) the Company is subject to
a Change in Control before the Optionee's Service terminates and (ii) the repurchase right is not assigned to the entity that employs the Optionee immediately after the Change in Control or to
its parent or subsidiary. Notwithstanding the foregoing, in the event that (i) there is an Involuntary Termination within twelve months after a Change in Control and (ii) the repurchase
right had been assigned to the entity that employs the Optionee immediately after the Change in Control or to its parent or subsidiary, then the repurchase right shall lapse and an additional number
of Shares shall become vested as if the Optionee performed Service for an additional twelve months. 



 
 

SECTION 7.    PAYMENT FOR SHARES.    
    


        (a)   General Rule.    The entire Purchase Price or Exercise Price of Shares issued under the Plan shall be payable
in cash or cash equivalents at the time when such Shares are purchased, except as otherwise provided in this Section 7. 


        (b)   Surrender of Stock.    To the extent that a Stock Option Agreement so provides, all or any part of the Exercise
Price may be paid by surrendering, or attesting to the ownership of, Shares that are already owned by the Optionee. Such Shares shall be surrendered to the Company in good form for transfer and shall
be valued at their Fair Market Value on the date when the Option is exercised. The Optionee shall not surrender, or attest to the ownership of, Shares in payment of the Exercise Price if such action
would cause the Company to recognize compensation expense (or additional compensation expense) with respect to the Option for financial reporting purposes. 


        (c)   Services Rendered.    At the discretion of the Board of Directors, Shares may be awarded under the Plan in
consideration of services rendered to the Company, a Parent or a Subsidiary prior to the award. At the discretion of the Board of Directors, Shares may also be awarded under the Plan in consideration
of services to be rendered to the Company, a Parent or a Subsidiary after the award, except that the par value of such Shares, if newly issued, shall be paid in cash or cash equivalents. 


        (d)   Promissory Note.    To the extent that a Stock Option Agreement or Stock Purchase Agreement so provides, all or
a portion of the Exercise Price or Purchase Price (as the case may be) of Shares issued under the Plan may be paid with a full-recourse promissory note. However, the par value of the
Shares, if newly issued, shall be paid in cash or cash equivalents. The Shares shall be pledged as 


5







 



security
for payment of the principal amount of the promissory note and interest thereon. The interest rate payable under the terms of the promissory note shall not be less than the minimum rate (if
any) required to avoid the imputation of additional interest under the Code. Subject to the foregoing, the Board of Directors (at its sole discretion) shall specify the term, interest rate,
amortization requirements (if any) and other provisions of such note. 


        (e)   Exercise/Sale.    To the extent that a Stock Option Agreement so provides, and if Stock is publicly traded,
payment may be made all or in part by the delivery (on a form prescribed by the Company) of an irrevocable direction to a securities broker approved by the Company to sell Shares and to deliver all or
part of the sales proceeds to the Company in payment of all or part of the Exercise Price and any withholding taxes. 



        (f)    Exercise/Pledge.    To the extent that a Stock Option Agreement so provides, and if Stock is publicly traded,
payment may be made all or in part by the delivery (on a form prescribed by the Company) of an irrevocable direction to pledge Shares to a securities broker or lender approved by the Company, as
security for a loan, and to deliver all or part of the loan proceeds to the Company in payment of all or part of the Exercise Price and any withholding taxes. 


 
 

SECTION 8.    ADJUSTMENT OF SHARES.    
    



        (a)   General.    In the event of a subdivision of the outstanding Stock, a declaration of a dividend payable in
Shares, a declaration of an extraordinary dividend payable in a form other than Shares in an amount that has a material effect on the Fair Market Value of the Stock, a combination or consolidation of
the outstanding Stock into a lesser number of Shares, a recapitalization, a spin-off, a reclassification or a similar occurrence, the Board of Directors shall make appropriate adjustments
in one or more of (i) the number of Shares available for future grants under Section 4, (ii) the number of Shares covered by each outstanding Option or (iii) the Exercise
Price under each outstanding Option. 


        (b)   Mergers and Consolidations.    In the event that the Company is a party to a merger or consolidation,
outstanding Options shall be subject to the agreement of merger or consolidation. Such agreement, without the Optionees' consent, may provide for: 



        (i)    The
continuation of such outstanding Options by the Company (if the Company is the surviving corporation); 


        (ii)   The
assumption of the Plan and such outstanding Options by the surviving corporation or its parent; 


        (iii)  The
substitution by the surviving corporation or its parent of options with substantially the same terms for such outstanding Options; or 


        (iv)  The
cancellation of such outstanding Options without payment of any consideration. 




        (c)   Reservation of Rights.    Except as provided in this Section 8, an Optionee or Purchaser shall have no
rights by reason of (i) any subdivision or consolidation of shares of stock of any class, (ii) the payment of any dividend or (iii) any other increase or decrease in the number of
shares of stock of any class. Any issuance by the Company of shares of stock of any class, or securities convertible into shares of stock of any class, shall not affect, and no adjustment by reason
thereof shall be made with respect to, the number or Exercise Price of Shares subject to an Option. The grant of an Option pursuant to the Plan shall not affect in any way the right or power of the
Company to make adjustments, reclassifications, reorganizations or changes of its capital or business structure, to merge or consolidate or to dissolve, liquidate, sell or transfer all or any part of
its business or assets. 


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SECTION 9.    SECURITIES LAW REQUIREMENTS.    
    


        (a)   General.    Shares shall not be issued under the Plan unless the issuance and delivery of such Shares comply
with (or are exempt from) all applicable requirements of law, including (without limitation) the Securities Act of 1933, as amended, the rules and regulations promulgated thereunder, state securities
laws and regulations, and the regulations of any stock exchange or other securities market on which the Company's securities may then be traded. 


        (b)   Financial Reports.    The Company each year shall furnish to Optionees, Purchasers and stockholders who have
received Stock under the Plan its balance sheet and income statement, unless such Optionees, Purchasers or stockholders are key Employees whose duties with the Company assure them access to equivalent
information. Such balance sheet and income statement need not be audited. 


 
 

SECTION 10.    NO RETENTION RIGHTS.    
    


        Nothing in the Plan or in any right or Option granted under the Plan shall confer upon the Purchaser or Optionee any right to continue in Service for any period
of specific duration or interfere with or otherwise restrict in any way the rights of the Company (or any Parent or Subsidiary employing or retaining the Purchaser or Optionee) or of the Purchaser or
Optionee, which rights are hereby expressly reserved by each, to terminate his or her Service at any time and for any reason, with or without cause. 


 
 

SECTION 11.    DURATION AND AMENDMENTS.    
    


        (a)   Term of the Plan.    The Plan, as set forth herein, shall become effective on the date of its adoption by the
Board of Directors, subject to the approval of the Company's stockholders. In the event that the stockholders fail to approve the Plan within 12 months after its adoption by the Board of
Directors, any grants of Options or sales or awards of Shares that have already occurred shall be rescinded, and no additional grants, sales or awards shall be made thereafter under the Plan. The Plan
shall terminate automatically 10 years after its adoption by the Board of Directors and may be terminated on any earlier date pursuant to Subsection (b) below. 


        (b)   Right to Amend or Terminate the Plan.    The Board of Directors may amend, suspend or terminate the Plan at any
time and for any reason; provided, however, that any amendment of the Plan which increases the number of Shares available for issuance under the Plan (except as provided in Section 8), or which
materially changes the class of persons who are eligible for the grant of ISOs, shall be subject to the approval of the Company's stockholders. Stockholder approval shall not be required for any other
amendment of the Plan. 


        (c)   Effect of Amendment or Termination.    No Shares shall be issued or sold under the Plan after the termination
thereof, except upon exercise of an Option granted prior to such termination. The termination of the Plan, or any amendment thereof, shall not affect any Share previously issued or any Option
previously granted under the Plan. 


 
 

SECTION 12.    DEFINITIONS.    
    


        (a)   "Board of Directors" shall mean the Board of Directors of the Company, as constituted from time to time. 


        (b)   "Cause" shall mean (i) the unauthorized use or disclosure of the confidential information or trade secrets of the
Company, which use causes material harm to the Company, (ii) conviction of a felony under the laws of the United States or any state thereof, (iii) gross negligence or
(iv) repeated 


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failure
to perform lawful assigned duties for thirty days after receiving written notification from the Board of Directors. 


        (c)   "Change in Control" shall mean: 



        (i)    The
consummation of a merger or consolidation of the Company with or into another entity or any other corporate reorganization, if more than 50% of the combined voting
power of the continuing or surviving entity's securities outstanding immediately after such merger, consolidation or other reorganization is owned by persons who were not stockholders of the Company
immediately prior to such merger, consolidation or other reorganization; 


        (ii)   The
acquisition, directly or indirectly, by any person or related group of persons (other than the Company or a person that directly or indirectly controls, is
controlled by, or is under common control with, the Company) of beneficial ownership (within the meaning of Rule 13d-3 of the Securities Exchange Act of 1934, as amended) of
securities possessing more than 50% of the total combined voting power of the Company's outstanding securities pursuant to a tender or exchange offer made directly to the Company's stockholders; or 


        (iii)  The
sale, transfer or other disposition of all or substantially all of the Company's assets. 




A
transaction shall not constitute a Change in Control if its sole purpose is to change the state of the Company's incorporation or to create a holding company that will be owned in substantially the
same proportions by the persons who held the Company's securities immediately before such transaction. 



        (d)   "Code" shall mean the Internal Revenue Code of 1986, as amended. 


        (e)   "Committee" shall mean a committee of the Board of Directors, as described in Section 2(a). 


        (f)    "Company" shall mean Theravance, Inc., a Delaware corporation. 



        (g)   "Consultant" shall mean an individual who performs bona fide services for the Company, a Parent or a Subsidiary as a
consultant or advisor, excluding Employees and Outside Directors. 


        (h)   "Disability" shall mean that the Optionee is unable to engage in any substantial gainful activity by reason of any
medically determinable physical or mental impairment. 


        (i)    "Employee" shall mean any individual who is a common-law employee of the Company, a Parent or a Subsidiary. 



        (j)    "Exercise Price" shall mean the amount for which one Share may be purchased upon exercise of an Option, as specified by
the Board of Directors in the applicable Stock Option Agreement. 


        (k)   "Fair Market Value" shall mean the fair market value of a Share, as determined by the Board of Directors in good faith.
Such determination shall be conclusive and binding on all persons. 


        (l)    "Involuntary Termination" shall mean the termination of Service which occurs by reason of: 



        (i)    an
involuntary dismissal or discharge by the Company for reasons other than for Cause; or 


        (ii)   a
voluntary resignation following (i) a change in Optionee's or Purchaser's position with the Company (or Parent or Subsidiary employing Optionee or Purchaser)
which materially reduces Optionee's or Purchaser's level of responsibility, (ii) a reduction in Optionee's or Purchaser's level of compensation (including base salary, fringe benefits and
participation in corporate-performance based bonus or incentive programs) by more than fifteen percent or (iii) a relocation of the workplace of Optionee or Purchaser more than fifty miles away
from the workplace designated by the Company on Optionee's or Purchaser's initial date of service. 



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        (m)  "ISO" shall mean an employee incentive stock option described in Section 422(b) of the Code. 



        (n)   "Nonstatutory Option" shall mean a stock option not described in Sections 422(b) or 423(b) of the Code. 


        (o)   "Option" shall mean an ISO or Nonstatutory Option granted under the Plan and entitling the holder to purchase Shares. 


        (p)   "Optionee" shall mean an individual who holds an Option. 


        (q)   "Outside Director" shall mean a member of the Board of Directors who is not an Employee. 



        (r)   "Parent" shall mean any corporation (other than the Company) in an unbroken chain of corporations ending with the
Company, if each of the corporations other than the Company owns stock possessing 50% or more of the total combined voting power of all classes of stock in one of the other corporations in such chain.
A corporation that attains the status of a Parent on a date after the adoption of the Plan shall be considered a Parent commencing as of such date. 


        (s)   "Plan" shall mean this Theravance, Inc. 1997 Stock Plan. 



        (t)    "Purchase Price" shall mean the consideration for which one Share may be acquired under the Plan (other than upon
exercise of an Option), as specified by the Board of Directors. 


        (u)   "Purchaser" shall mean an individual to whom the Board of Directors has offered the right to acquire Shares under the
Plan (other than upon exercise of an Option). 


        (v)   "Service" shall mean service as an Employee, Outside Director or Consultant. 



        (w)  "Share" shall mean one share of Stock, as adjusted in accordance with Section 8 (if applicable). 


        (x)   "Stock" shall mean the Common Stock of the Company, with a par value of $0.01 per Share. 


        (y)   "Stock Option Agreement" shall mean the agreement between the Company and an Optionee which contains the terms,
conditions and restrictions pertaining to the Optionee's Option. 


        (z)   "Stock Purchase Agreement" shall mean the agreement between the Company and a Purchaser who acquires Shares under the
Plan which contains the terms, conditions and restrictions pertaining to the acquisition of such Shares. 


        (aa) "Subsidiary" means any corporation (other than the Company) in an unbroken chain of corporations beginning with the
Company, if each of the corporations other than the last corporation in the unbroken chain owns stock possessing 50% or more of the total combined voting power of all classes of stock in one of the
other corporations in such chain. A corporation that attains the status of a Subsidiary on a date after the adoption of the Plan shall be considered a Subsidiary commencing as of such date. 


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QuickLinks



Exhibit 10.1


1997 STOCK PLAN ADOPTED ON JUNE 23, 1997

TABLE OF CONTENTS


THERAVANCE, INC. 1997 STOCK PLAN


SECTION 1. ESTABLISHMENT AND PURPOSE.

SECTION 2. ADMINISTRATION.

SECTION 3. ELIGIBILITY .

SECTION 4. STOCK SUBJECT TO PLAN.

SECTION 5. TERMS AND CONDITIONS OF AWARDS OR SALES.

SECTION 6. TERMS AND CONDITIONS OF OPTIONS.

SECTION 7. PAYMENT FOR SHARES.

SECTION 8. ADJUSTMENT OF SHARES.

SECTION 9. SECURITIES LAW REQUIREMENTS.

SECTION 10. NO RETENTION RIGHTS.

SECTION 11. DURATION AND AMENDMENTS.

SECTION 12. DEFINITIONS.