Second Amendment to the Rights Agreement



 Exhibit 4.2 
  

SECOND AMENDMENT 
 TO THE

 RIGHTS AGREEMENT 
  
 This Second Amendment, dated as of June 11, 2004 (this “Second Amendment”), amends the Rights Agreement, dated as of March 16, 2001, by
and between ACLARA BioSciences, Inc., a Delaware corporation (the “Company”), and Mellon Investor Services LLC, a New Jersey limited liability company, as rights agent (the “Rights Agent”), as amended by the
Amendment to the Rights Agreement dated as of May 28, 2004 (the “First Amendment”) (as amended by the First Amendment, the “Rights Agreement”). 
  
 WITNESSETH 
  
 WHEREAS, the Company and the Rights Agent have heretofore executed and entered into the Rights Agreement; 
  
 WHEREAS, pursuant to Section 26 of the Rights Agreement, the Company
and the Rights Agent may from time to time supplement or amend the Rights Agreement in accordance with the provisions of Section 26 thereof; and 
  
 WHEREAS, the Board of Directors of the Company has determined that it is in the best interests of the Company and the holders of the Rights to
amend the Rights Agreement as provided herein. 
  
 NOW
THEREFORE, in consideration of the foregoing and the mutual agreements set forth herein, the Company and the Rights Agent agree as follows: 
  
 1. Any term not defined herein shall have the meaning ascribed to it in the Rights Agreement. 
  
 2. Section 1.1 of the Rights Agreement shall be amended and restated in its
entirety as follows: 
  
 “1.1 “Acquiring Person”
shall mean any Person (as such term is hereinafter defined) who or which, together with all Affiliates and Associates (as such terms are hereinafter defined) of such Person, shall be the Beneficial Owner (as such term is hereinafter defined) of 20%
or more of the Common Shares of the Company then outstanding but shall not include (i) an Exempt Person (as such term is hereinafter defined), (ii) if, as of the date hereof, any Person is the Beneficial Owner of 20% or more of the Common Shares
outstanding (an “Existing Holder”), such Existing Holder shall not be or become an “Acquiring Person” unless and until such time as such Existing Holder shall become the Beneficial Owner of one or more additional Common Shares of
the Company (other than pursuant to a dividend or distribution paid or made by the Company on the outstanding Common Shares in Common Shares or pursuant to a split or subdivision of the outstanding Common Shares), unless, upon becoming the
Beneficial Owner of such additional Common Shares, such Existing Holder is not then the Beneficial 







 Owner of 20% or more of the Common Shares then outstanding, or (iii) ViroLogic, Inc., a Delaware
corporation (“Parent”), Apollo Acquisition Sub, Inc., a Delaware corporation (“Merger Sub I”), Apollo Merger Subsidiary, LLC, a Delaware limited liability company (“Merger Sub II,” and together with Merger Sub I, the
“Merger Subs”), or any Affiliate or Associate of Parent or the Mergers Subs; provided, however, that Parent, the Merger Subs or any Affiliate or Associate of Parent or Merger Subs will become an “Acquiring Person” in the event
that Parent, Merger Subs, or any Affiliate or Associate of Parent or Merger Subs becomes the Beneficial Owner, individually or in the aggregate, of an aggregate of 20% or more of the Common Shares of the Company then outstanding other than pursuant
to the terms of the Agreement and Plan of Merger and Reorganization dated as of May 28, 2004 (the “Merger Agreement”), among the Company, Parent and the Merger Subs. Notwithstanding the foregoing, no Person shall become an “Acquiring
Person” as the result of an acquisition of Common Shares by the Company which, by reducing the number of shares outstanding, increases the proportionate number of shares beneficially owned by such Person to 20% or more of the Common Shares of
the Company then outstanding; provided, however, that if a Person shall become the Beneficial Owner of 20% or more of the Common Shares of the Company then outstanding solely by reason of share purchases by the Company and shall, after such share
purchases by the Company, become the Beneficial Owner of one or more additional Common Shares of the Company (other than pursuant to a dividend or distribution paid or made by the Company on the outstanding Common Shares in Common Shares or pursuant
to a split or subdivision of the outstanding Common Shares), then such Person shall be deemed to be an “Acquiring Person” unless upon becoming the Beneficial Owner of such additional shares of Common Stock such Person does not beneficially
own 20% or more of the shares of Common Stock then outstanding. Notwithstanding the foregoing, if the Board of Directors of the Company determines in good faith that a Person who would otherwise be an “Acquiring Person,” as defined
pursuant to the foregoing provisions of this Section 1.1, has become such inadvertently (including, without limitation, because (A) such Person was unaware that it beneficially owned a percentage of Common Stock that would otherwise cause such
Person to be an “Acquiring Person” or (B) such Person was aware of the extent of its Beneficial Ownership of Common Stock but had no actual knowledge of the consequences of such Beneficial Ownership under this Agreement), and without any
intention of changing or influencing control of the Company, and such Person divests as promptly as practicable a sufficient number of Common Shares so that such Person would no longer be an Acquiring Person, as defined pursuant to the foregoing
provisions of this Section 1.1, then such Person shall not be deemed to be or have become an “Acquiring Person” at any time for any purposes of this Agreement. For all purposes of this Agreement, any calculation of the number of Common
Shares outstanding at any particular 
  

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 time, including for purposes of determining the particular percentage of such outstanding Common Shares
of which any Person is the Beneficial Owner, shall be made in accordance with the last sentence of Rule 13d-3(d)(1)(i) of the General Rules and Regulations under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), as in
effect on the date of this Agreement.” 
  
 3. The first
sentence of Section 3.1 of the Rights Agreement shall be amended as follows: 
  
 “Until the earlier of the close of business on (i) the tenth day after the Shares Acquisition Date or (ii) the tenth Business Day after the date of the commencement of, or first public announcement of the intent
of any Person (other than an Exempt Person) to commence, a tender or exchange offer the consummation of which would result in any Person (other than an Exempt Person) becoming the Beneficial Owner of Common Shares aggregating 20% or more of the then
outstanding Common Shares of the Company (the earlier of (i) and (ii) being herein referred to as the “Distribution Date”), (x) the Rights (unless earlier expired, redeemed or terminated) will be evidenced (subject to the provisions of
Section 3.2) by the certificates for Common Shares registered in the names of the holders thereof (which certificates for Common Shares shall also be deemed to be Right Certificates) and not by separate certificates, and (y) the Rights (and the
right to receive certificates therefor) will be transferable only in connection with the transfer of the underlying Common Shares.” 
  
 4. This Second Amendment shall be deemed to be a contract made under the laws of the State of Delaware and for all purposes shall be governed by and
construed in accordance with the laws of such State applicable to contracts to be made and performed entirely within such State; provided, however, that all provisions regarding the rights, duties and obligations of the Rights Agent shall be
governed by and construed in accordance with the laws of the State of New York applicable to contracts made and to be performed entirely within such State. 
  
 5. This Second Amendment may be executed in any number of counterparts and each of such counterparts shall for all purposes be deemed to be an original,
and all such counterparts shall together constitute but one and the same instrument. 
  
 6. Except as expressly amended hereby, the Rights Agreement shall remain in full force and effect. 
  
 7. The undersigned officer of the Company, does hereby certify to the Rights Agent that this Second Amendment (i) complies with the terms of Section 26 of
the Rights Agreement and (ii) will not change or increase the rights, duties, liabilities or obligations of the Rights Agent under the Rights Agreement. 
  

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 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the day and
year first above written. 
  

			
	 ACLARA BIOSCIENCES, INC.,
 a Delaware corporation

		
	 By:
	 	 /s/ Alfred Merriweather


	 Name:
	 	 Alfred Merriweather

	 Title:
	 	 Chief Financial Officer

	
	 MELLON INVESTOR SERVICES LLC,
 as Rights Agent

		
	 By:
	 	 /s/ Cecil D. Bobey


	 Name:
	 	 Cecil D. Bobey

	 Title:
	 	 Assistant Vice President