UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-K/A

(Amendment No. 2)

(Mark One)

|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended December 31, 2011

or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

Commission file number 001-32559





Medical
Properties Trust, Inc.

MPT Operating Partnership, L.P.

(Exact Name of Registrant as Specified in Its Charter)



|                                                               |  |                                  
|-------------------------------------------------------------- |  | ---------------------------------
|Maryland Delaware                                              |  | 20-0191742 20-0242069            
|(State or Other Jurisdiction of
Incorporation or Organization) |  | (IRS Employer Identification No.)
|                                                               | 
|1000 Urban Center Drive, Suite 501
Birmingham, AL              |  | 35242                            
|(Address of Principal Executive Offices)                       |  | (Zip Code)                       

(205) 969-3755

(Registrants telephone number, including area code)

Securities
registered pursuant to Section 12(b) of the Act:



|                                                                           |  |                                          
|-------------------------------------------------------------------------- |  | -----------------------------------------
|Title of Each Class                                                        |  | Name of Each Exchange on Which Registered
|Common Stock, par value $0.001 per share of
Medical Properties Trust, Inc. |  | New York Stock Exchange                  

Securities registered pursuant to Section 12(g) of the Act:

None





Indicate by
check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.    Yes  x    No   ̈

Indicate by check mark if the registrant is not required to file reports pursuant
to Section 13 or Section 15(d) of the Act.    Yes   ̈    No  x

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past
90 days.    Yes  x    No   ̈

Indicate by check mark whether the registrant has submitted electronically and posted on its Website, if any, every Interactive Data File
required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such
files).    Yes  x    No   ̈

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be
contained, to the best of the registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment of this Form 10-K.   ̈

Indicate by check mark whether the registrant is a large accelerated filer, an
accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the Exchange Act.
(Check one):



|                                                             |  |                                                  |  |                           |  |  
|------------------------------------------------------------ |  | ------------------------------------------------ |  | ------------------------- |  | -
|Large accelerated filer (Medical Properties Trust Inc. only) |  | x                                                |  | Accelerated filer         |  |  ̈
|                                                             |  |                                                  | 
|Non-accelerated filer (MPT Operating Partnership, L.P. only) |  | x  (Do not check if a smaller reporting company) |  | Smaller reporting company |  |  ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the
Act).    Yes   ̈    No  x

As of June 30, 2011, the aggregate market value of the 111,712,079 shares of common stock, par value $0.001 per share
(Common Stock), held by non-affiliates of the registrant was $1,284,688,909 based upon the last reported sale price of $11.50 on the New York Stock Exchange. For purposes of the foregoing calculation only, all directors and executive
officers of the registrant have been deemed affiliates.

As of February 22, 2012, 135,275,389 shares of Medical
Properties Trust, Inc. Common Stock were outstanding.





DOCUMENTS
INCORPORATED BY REFERENCE

Portions of the registrants definitive Proxy Statement for the Annual Meeting of
Stockholders to be held on May 17, 2012 are incorporated by reference into Items 10 through 14 of Part III, of this Annual Report on Form 10-K.









---

MEDICAL PROPERTIES TRUST, INC.

MPT OPERATING PARTNERSHIP, L.P.

AMENDMENT NO. 2 TO ANNUAL REPORT ON FORM 10-K

FOR THE FISCAL YEAR ENDED
DECEMBER 31, 2011

This Amendment No. 2 to the Annual Report on Form 10-K for the fiscal year ended December 31, 2011 of Medical
Properties Trust, Inc. and MPT Operating Partnership, L.P. is filed for the sole purpose of adding the consent of the independent registered public accounting firm for Prime Healthcare Services, Inc. and Subsidiaries (Prime). At
December 31, 2011, our properties leased to Prime were more than 20% of our assets. Since these properties are leased to Prime under long-term, triple-net leases that transfer substantially all operating costs to Prime, financial information
about Prime may be relevant to investors. We filed Primes audited financial statements for the years ended December 31, 2011 and 2010 as an exhibit to Amendment No. 1 to the Annual Report on Form 10-K filed on May 10, 2012 but
inadvertently omitted the consent of Primes independent registered public accounting firm, Moss Adams LLP. Item 14 of Part IV has also been amended to reflect the addition of the consent to our list of exhibits.

Other than as expressly set forth above, this Amendment does not, and does not purport to, update or restate the information in any other Item of the
originally filed annual report.

TABLE OF CONTENTS



|           |  |                                           
|---------- |  | ------------------------------------------
|PART IV   
|ITEM 15.   |  | Exhibits and Financial Statement Schedules
|           | 
|SIGNATURES |  |                                           



---

PART IV



|ITEM 15. | Exhibits and Financial Statement Schedules
|-------- | ------------------------------------------

(b) Exhibits



|               |  |                                                                                                                                                                                                                                                                            
|-------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit
Number |  | Exhibit Title                                                                                                                                                                                                                                                              
|               | 
|3.1(1)         |  | Registrants Second Articles of Amendment and Restatement                                                                                                                                                                                                                  
|               | 
|3.2(2)         |  | Articles of Amendment of Registrants Second Articles of Amendment and Restatement                                                                                                                                                                                         
|               | 
|3.3(3)         |  | Registrants Second Amended and Restated Bylaws                                                                                                                                                                                                                            
|               | 
|4.1(1)         |  | Form of Common Stock Certificate                                                                                                                                                                                                                                           
|               | 
|4.2(4)         |  | Indenture, dated July 14, 2006, among Registrant, MPT Operating Partnership, L.P. and the Wilmington Trust Company, as trustee                                                                                                                                             
|               | 
|4.3(13)        |  | Indenture, dated as of March 26, 2008, among MPT Operating Partnership, L.P., as Issuer, Medical Properties Trust, Inc., as Guarantor, and Wilmington Trust Company, as
Trustee.                                                                                           
|               | 
|4.4(9)         |  | Indenture, dated as of April 26, 2011, Medical Properties Trust, Inc., MPT Operating Partnership, L.P., MPT Finance Corporation, the Subsidiary Guarantors and Wilmington Trust
Company, as Trustee.                                                                       
|               | 
|10.1(11)       |  | Second Amended and Restated Agreement of Limited Partnership of MPT Operating Partnership, L.P.                                                                                                                                                                            
|               | 
|10.2(6)        |  | Amended and Restated 2004 Equity Incentive Plan                                                                                                                                                                                                                            
|               | 
|10.3(7)        |  | Form of Stock Option Award                                                                                                                                                                                                                                                 
|               | 
|10.4(7)        |  | Form of Restricted Stock Award                                                                                                                                                                                                                                             
|               | 
|10.5(7)        |  | Form of Deferred Stock Unit Award                                                                                                                                                                                                                                          
|               | 
|10.6(1)        |  | Employment Agreement between Registrant and Edward K. Aldag, Jr., dated September 10, 2003                                                                                                                                                                                 
|               | 
|10.7(1)        |  | First Amendment to Employment Agreement between Registrant and Edward K. Aldag, Jr., dated March 8, 2004                                                                                                                                                                   
|               | 
|10.8(1)        |  | Employment Agreement between Registrant and R. Steven Hamner, dated September 10, 2003                                                                                                                                                                                     
|               | 
|10.9           |  | Not used                                                                                                                                                                                                                                                                   
|               | 
|10.10(1)       |  | Employment Agreement between Registrant and Emmett E. McLean, dated September 10, 2003                                                                                                                                                                                     
|               | 
|10.12(1)       |  | Form of Indemnification Agreement between Registrant and executive officers and directors                                                                                                                                                                                  
|               | 
|10.13(11)      |  | Form of Medical Properties Trust, Inc. 2007 Multi-Year Incentive Plan Award Agreement (LTIP Units)                                                                                                                                                                         
|               | 
|10.14(11)      |  | Form of Medical Properties Trust, Inc. 2007 Multi-Year Incentive Plan Award Agreement (Restricted Shares)                                                                                                                                                                  
|               | 
|10.17(16)      |  | Second Amendment to Employment Agreement between Registrant and Edward K. Aldag, Jr., dated September 29, 2006                                                                                                                                                             
|               | 
|10.18(16)      |  | First Amendment to Employment Agreement between Registrant and R. Steven Hamner, dated September 29, 2006                                                                                                                                                                  
|               | 
|10.19(16)      |  | First Amendment to Employment Agreement between Registrant and Emmett E. McLean, dated September 29, 2006                                                                                                                                                                  
|               | 
|10.21(8)       |  | Second Amended and Restated 2004 Equity Incentive Plan                                                                                                                                                                                                                     
|               | 
|10.22(17)      |  | Second Amendment to Employment Agreement between Registrant and William G. McKenzie, dated February 27, 2009                                                                                                                                                               
|               | 
|10.25(17)      |  | Second Amendment to Employment Agreement between Registrant and Emmett E. McLean, dated January 1, 2008                                                                                                                                                                    
|               | 
|10.26(17)      |  | Third Amendment to Employment Agreement between Registrant and Emmett E. McLean, dated January 1, 2009                                                                                                                                                                     
|               | 
|10.27(17)      |  | Second Amendment to Employment Agreement between Registrant and Richard S. Hamner, dated January 1, 2008                                                                                                                                                                   
|               | 
|10.28(17)      |  | Third Amendment to Employment Agreement between Registrant and R. Steven Hamner, dated January 1, 2009                                                                                                                                                                     
|               | 
|10.29(17)      |  | Third Amendment to Employment Agreement between Registrant and Edward K. Aldag, Jr., dated January 1, 2008                                                                                                                                                                 
|               | 
|10.30(17)      |  | Fourth Amendment to Employment Agreement between Registrant and Edward K. Aldag, Jr., dated January 1, 2009                                                                                                                                                                
|               | 
|10.31(17)      |  | Third Amendment to Employment Agreement between Registrant and William G. McKenzie, dated January 1, 2008                                                                                                                                                                  
|               | 
|10.32(17)      |  | Fourth Amendment to Employment Agreement between Registrant and William G. McKenzie, dated January 1, 2009                                                                                                                                                                 
|               | 
|10.34(9)       |  | Amended and Restated Revolving Credit and Term Loan Agreement, dated as of April 26, 2011, among Medical Properties Trust, Inc., MPT Operating Partnership, L.P., KeyBank
National Association as syndication agent, and JPMorgan Chase Bank, N.A., as administrative agent
|               | 
|12.1(19)       |  | Statement re Computation of Ratios                                                                                                                                                                                                                                         
|               | 
|21.1(19)       |  | Subsidiaries of Registrant                                                                                                                                                                                                                                                 
|               | 
|23.1(21)       |  | Consent of PricewaterhouseCoopers LLP                                                                                                                                                                                                                                      
|               | 
|23.1(22)       |  | Consent of Moss Adams LLP                                                                                                                                                                                                                                                  
|               | 
|31.1(22)       |  | Certification of Chief Executive Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934. (Medical Properties Trust,
Inc.)                                                                                                                            



---

|               |  |                                                                                                                                                                                                                                                                             
|-------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit
Number |  | Exhibit Title                                                                                                                                                                                                                                                               
|               | 
|31.2(22)       |  | Certification of Chief Financial Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934. (Medical Properties Trust, Inc.)                                                                                                                             
|               | 
|31.3(22)       |  | Certification of Chief Executive Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934. (MPT Operating Partnership, L.P.)                                                                                                                            
|               | 
|31.4(22)       |  | Certification of Chief Financial Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934. (MPT Operating Partnership, L.P.)                                                                                                                            
|               | 
|32.1(19)       |  | Certification of Chief Executive Officer and Chief Financial Officer pursuant to Rule 13a-14(b) under the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350 as adopted
pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. (Medical Properties Trust, Inc.) 
|               | 
|32.2(19)       |  | Certification of Chief Executive Officer and Chief Financial Officer pursuant to Rule 13a-14(b) under the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350 as adopted
pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. (MPT Operating Partnership, L.P.)
|               | 
|99.1(21)       |  | Consolidated Financial Statements of Prime Healthcare Services, Inc. as of December 31, 2011 and 2010                                                                                                                                                                       

The following materials from Medical Properties Trust, Inc.s and MPT Operating Partnership,
L.P.s Annual Report on Form 10-K for the year ended December 31, 2011 formatted in XBRL (eXtensible Business Reporting Language): (i) the Consolidated Balance Sheets, (ii) the Consolidated Statements of Income; (iii) the
Consolidated Statements of Equity, (iv) the Consolidated Statements of Cash Flows; and (v) related notes to these financial statements.



|                |  |                                                       
|--------------- |  | ------------------------------------------------------
|Exhibit 101.INS |  | XBRL Instance Document                                
|                | 
|Exhibit 101.SCH |  | XBRL Taxonomy Extension Schema Document               
|                | 
|Exhibit 101.CAL |  | XBRL Taxonomy Extension Calculation Linkbase Document 
|                | 
|Exhibit 101.DEF |  | XBRL Taxonomy Extension Definition Linkbase Document  
|                | 
|Exhibit 101.LAB |  | XBRL Taxonomy Extension Label Linkbase Document       
|                | 
|Exhibit 101.PRE |  | XBRL Taxonomy Extension Presentation Linkbase Document



|(1) | Incorporated by reference to Registrants Registration Statement on Form S-11 filed with the Commission on October 26, 2004, as amended (File
No. 333-119957).
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Incorporated by reference to Registrants current report on Form 8-K, filed with the Commission on November 24, 2009.
|--- | ---------------------------------------------------------------------------------------------------------------------

|(3) | Incorporated by reference to Registrants quarterly report on Form 10-Q for the quarter ended September 30, 2005, filed with the Commission on
November 10, 2005.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------

|(4) | Incorporated by reference to Registrants current report on Form 8-K, filed with the Commission on July 20, 2006.
|--- | -----------------------------------------------------------------------------------------------------------------

|(5) | Incorporated by reference to Registrants current report on Form 8-K, filed with the Commission on November 13, 2006.
|--- | ---------------------------------------------------------------------------------------------------------------------

|(6) | Incorporated by reference to Registrants definitive proxy statement on Schedule 14A, filed with the Commission on September 13, 2005.
|--- | --------------------------------------------------------------------------------------------------------------------------------------

|(7) | Incorporated by reference to Registrants current report on Form 8-K, filed with the Commission on October 18, 2005.
|--- | --------------------------------------------------------------------------------------------------------------------

|(8) | Incorporated by reference to Registrants definitive proxy statement on Schedule 14A, filed with the Commission on April 14, 2007.
|--- | ----------------------------------------------------------------------------------------------------------------------------------

|(9) | Incorporated by reference to Registrants current report on Form 8-K, filed with the Commission on May 2, 2011.
|--- | ---------------------------------------------------------------------------------------------------------------

|(10) | Incorporated by reference to Registrants quarterly report on Form 10-Q for the quarter ended September 30, 2007, filed with the Commission on
November 9, 2007.
|---- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------

|(11) | Incorporated by reference to Registrants current report on Form 8-K, filed with the Commission on August 6, 2007.
|---- | ------------------------------------------------------------------------------------------------------------------

|(12) | Incorporated by reference to Registrants current report on Form 8-K, filed with the Commission on August 15, 2007.
|---- | -------------------------------------------------------------------------------------------------------------------

|(13) | Incorporated by reference to Registrants current report on Form 8-K, filed with the Commission on March 26, 2008.
|---- | ------------------------------------------------------------------------------------------------------------------

|(14) | Incorporated by reference to Registrants quarterly report on Form 10-Q for the quarter ended March 31, 2008, filed with the Commission on May 9,
2008.
|---- | -------------------------------------------------------------------------------------------------------------------------------------------------------

|(15) | Incorporated by reference to Registrants quarterly report on Form 10-Q for the quarter ended June 30, 2008, filed with the Commission on August 8,
2008.
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------

|(16) | Incorporated by reference to Registrants annual report on Form 10-K/A for the period ended December 31, 2007, filed with the Commission on July 11,
2008.
|---- | ----------------------------------------------------------------------------------------------------------------------------------------------------------

|(17) | Incorporated by reference to Registrants annual report on Form 10-K for the period ended December 31, 2008, filed with the Commission on March 13,
2009.
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------

|
|



---

|(18) | Incorporated by reference to Registrants current report on Form 8-K, filed with the Commission on June 11, 2010.
|---- | -----------------------------------------------------------------------------------------------------------------

|(19) | Previously filed as an exhibit to Registrants Annual Report on form 10-K, filed with the Commission on February 29, 2012.
|---- | --------------------------------------------------------------------------------------------------------------------------

|(20) | Since affiliates of Prime Healthcare Services, Inc. lease more than 20% of our total assets under triple net leases, the financial status of Prime may be considered
relevant to investors. Primes most recently available audited consolidated financial statements (as of and for the years ended December 31, 2011 and 2010) are attached as Exhibit 99.1 to this Amendment No. 1 to the Annual Report
on Form 10-K. Refer to our 2010 Form 10-K/A filed on February 28, 2011 for the audited financial statements of Prime for the years ended December 31, 2010 and 2009. We have not participated in the preparation of Primes financial
statements nor do we have the right to dictate the form of any financial statements provided to us by Prime.
|---- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(21) | Included in Form 10-K Amendment No. 1 filed on May 10, 2012.
|---- | ------------------------------------------------------------

|(22) | Included in this Form 10-K Amendment No. 2.
|---- | -------------------------------------------

SIGNATURES

Pursuant to the requirements of
Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this Report to be signed on its behalf by the undersigned, thereunto duly authorized.



MEDICAL PROPERTIES TRUST, INC.By:

/s/ R. Steven HamnerR. Steven HamnerExecutive Vice President and Chief Financial Officer (Principal Financial and Accounting Officer)




MPT OPERATING PARTNERSHIP, L.P.By:

/s/ R. Steven HamnerR. Steven HamnerExecutive Vice President and Chief Financial Officer of the sole member of the general partner of MPT Operating Partnership,
L.P. (Principal Financial and Accounting Officer)


Date: September 21, 2012



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INDEX TO EXHIBITS



|               |  |                                                                                                                                                 
|-------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit
Number |  | Exhibit Title                                                                                                                                   
|               | 
|23.2           |  | Consent of Moss Adams LLP                                                                                                                       
|               | 
|31.1           |  | Certification of Chief Executive Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934.
(Medical Properties Trust, Inc.) 
|               | 
|31.2           |  | Certification of Chief Financial Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934.
(Medical Properties Trust, Inc.) 
|               | 
|31.3           |  | Certification of Chief Executive Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934.
(MPT Operating Partnership, L.P.)
|               | 
|31.4           |  | Certification of Chief Financial Officer pursuant to Rule 13a-14(a) under the Securities Exchange Act of 1934.
(MPT Operating Partnership, L.P.)