64808 Federal Register / Vol. 79, No. 211 / Friday, October 31, 2014 / Notices 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Government-Owned Inventions; 

Availability for Licensing 

AGENCY: National Institutes of Health, 

HHS. 

ACTION: Notice. 

SUMMARY: The inventions listed below 

are owned by an agency of the U.S. 

Government and are available for 

licensing in the U.S. in accordance with 

35 U.S.C. 209 and 37 CFR Part 404 to 

achieve expeditious commercialization 

of results of federally-funded research 

and development. Foreign patent 

applications are filed on selected 

inventions to extend market coverage 

for companies and may also be available 

for licensing. 

FOR FURTHER INFORMATION CONTACT: 

Licensing information and copies of the 

U.S. patent applications listed below 

may be obtained by writing to the 

indicated licensing contact at the Office 

of Technology Transfer, National 

Institutes of Health, 6011 Executive 

Boulevard, Suite 325, Rockville, 

Maryland 20852–3804; telephone: 301– 

496–7057; fax: 301–402–0220. A signed 

Confidential Disclosure Agreement will 

be required to receive copies of the 

patent applications. 

SUPPLEMENTARY INFORMATION: 

Technology descriptions follow. 

Resolution Enhancement Technique for 

Light Sheet Microscopy Systems 

Description of Technology: The 

invention pertains to a technique for 

enhancing the resolution of a light sheet 

microscopy technique by adding an 

additional enhanced depth-of-focus 

optical arrangement and high numerical 

aperture objective lens. The technique 

employs an arrangement of three 

objective lenses and a processor for 

combining captured images from the 

objectives. The resulting image 

composite retains the greater resolving 

power of the third high numerical 

aperture objective lens by imaging the 

light sheet with the third objective lens 

and enhanced depth-of-focus 

arrangement so that the overall 

resolution of the light sheet system is 

improved. The depth of field 

arrangement could be a simple 

oscillation of the third objective, or a 

‘‘layer cake’’ or cubic phase mask 

component. Any loss in lateral 

resolution that results from the depth of 

field arrangement may be compensated 

for by deconvolution. In some 

embodiments, other optics, such as an 

axicon or annular aperture, can provide 

extended depth of field. 

Potential Commercial Applications: 

Resolution enhancement in light 

microscopy 

Competitive Advantages: Image 

composition using processing system 

Development Stage: 

• Early-stage 

• Prototype 

Inventors: Hari Shroff (NIBIB), Yicong 

Wu (NIBIB), Sara Abrahamsson (The 

Rockefeller University) 

Intellectual Property: HHS Reference 

No. E–232–2014/0—U.S. Provisional 

Patent Application 62/054,484 filed 

September 24, 2014 

Related Technology: HHS Reference 

No. E–078–2011/0— 

• PCT Application No. PCT/US2012/ 

27524 filed March 02, 2012 

• U.S. Patent Application No. 14/

003,380 filed September 5, 2013, which 

published as US 2014–0126046–A1 on 

May 08, 2014 

Licensing Contact: Michael 

Shmilovich, Esq.; 301–435–5019; 

shmilovm@mail.nih.gov 

Collaborative Research Opportunity: 

The National Institute of Biomedical 

Imaging and Bioengineering is seeking 

statements of capability or interest from 

parties interested in collaborative 

research to further develop, evaluate or 

commercialize light sheet microscopy 

image resolution enhancement. For 

collaboration opportunities, please 

contact Cecilia Pazman at 301–594– 

4273 or pazmance@nhlbi.nih.gov. 

Resolution Enhancement for LineScanning Excitation Microscopy 

Description of Technology: The 

invention describes a method for 

improving the spatial resolution of 

optical microscopes that use linescanning excitation, such as linescanning confocal microscopes, linescanning STED microscopes, or linescanning light-sheet microscopes. 

Common elements of the invention 

include: (a) An apparatus for exciting 

and scanning a line-like excitation focus 

through the sample; (b) an optical 

arrangement on the detection side of the 

microscope for manipulating the 

spacing and/or width of the resulting 

fluorescence emissions; (c) integration 

and optional post-processing of the 

manipulated fluorescence emissions 

after capture by an area detector such as 

a camera. The resolution increase may 

be performed with no or marginal 

decrease in temporal resolution relative 

to the conventional line-scanning 

microscopes upon which the technique 

is based. 

Potential Commercial Applications: 

Fluorescence microscopy 

Competitive Advantages: 

• Improved resolution 

• Enhanced acquisition speed relative 

to other forms of super-resolution 

microscopy 

Development Stage: Prototype 

Inventors: Hari Shroff, Andrew York, 

John Giannini, Abhishek Kumar (all of 

NIBIB) 

Intellectual Property: HHS Reference 

No. E–225–2014—U.S. Provisional 

Patent Application 62/054,481 filed 

September 24, 2014 

Licensing Contact: Michael 

Shmilovich, Esq.; 301–435–5019; 

shmilovm@mail.nih.gov 

Collaborative Research Opportunity: 

The National Institute of Biomedical 

Imaging and Bioengineering is seeking 

statements of capability or interest from 

parties interested in collaborative 

research to further develop, evaluate or 

commercialize fluorescent microscopy. 

For collaboration opportunities, please 

contact Cecilia Pazman at 301–594– 

4273 or pazmance@nhlbi.nih.gov. 

Chemotherapeutic Anti-Cancer Agents 

Description of Technology: Available 

for licensing are new compounds 

derived from 4-benzyl-amino-benzyl 

alcohol. These compounds possess 

potent activity in multiple in vitro 

models of cancer cell growth inhibition 

and in vivo xenograft models of renal 

tumor regression. These compounds 

could potentially be developed into 

promising therapeutic agents for the 

treatment of various cancers. 

Potential Commercial Applications: 

Chemotherapy of cancer 

Competitive Advantages: 

• Extreme potency for tumor 

regression in vivo. 

• Compounds with similar profiles 

have been approved by the FDA as 

chemotherapeutic agents. 

—Preliminary toxicology data 

available. 

Development Stage: 

• In vitro data available 

• In vivo data available (animal) 

Inventors: Joel Morris and Donn 

Wishka (NCI) 

Intellectual Property: HHS Reference 

No. E–027–2014/0—U.S. Application 

No. 61/933,606 filed 20 Jan 2014 

Licensing Contact: Patrick McCue, 

Ph.D.; 301–435–5560; mccuepat@

od.nih.gov 

Novel Codon-Optimized Gene 

Therapeutic for Methylmalonic 

Acidemia 

Description of Technology: 

Methylmalonic Acidemia (MMA) is a 

metabolic disorder characterized by 

increased acidity in the blood and 

tissues due to toxic accumulation of 


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Federal Register / Vol. 79, No. 211 / Friday, October 31, 2014 / Notices 64809 

protein and fat by-products resulting in 

seizures, strokes, and chronic kidney 

failure. A significant portion of MMA 

cases stem from a deficiency in a key 

mitochondrial enzyme, methylmalonylCoA mutase (MUT), required to break 

down amino acids and lipids. Currently, 

there are no treatments for MMA and 

the disease is managed primarily with 

dietary restriction of amino acid 

precursors and liver-kidney 

transplantation in severe cases. 

The present invention describes a 

synthetic codon-optimized MUT gene 

(co-MUT) that improves expression of 

human methylmalonyl-CoA mutase. A 

series of novel gene therapy vectors 

containing co-MUT rescued MMA mice 

from lethality and lowered levels of 

methylmalonic acid in the blood. 

Results of pre-clinical efficacy studies 

demonstrate a promising therapy for 

MMA and other renal-associated 

disorders. 

Potential Commercial Applications: 

• The co-MUT transgene could be 

used to treat MMA patients. 

• In addition, it could be used to 

produce MUT in vitro for MMA enzyme 

replacement therapy. 

Competitive Advantages: co-MUT 

transgene could be used through nonviral and viral gene delivery. 

Development Stage: 

• In vitro data available 

• In vivo data available (animal) 

Inventors: Charles P. Venditti and 

Randy J. Chandler (NHGRI) 

Intellectual Property: HHS Reference 

No. E–243–2012/0— 

• U.S. Provisional Application No. 

61/792,081 filed 15 March 2013 

• PCT Application No. PCT/US2014/ 

028045 filed 14 March 2014 

Licensing Contact: Vince Contreras, 

Ph.D.; 301–435–4711; vince.contreras@

nih.gov 

Collaborative Research Opportunity: 

The Organic Acid Research Section at 

the National Human Genome Research 

Institute is seeking statements of 

capability or interest from parties 

interested in collaborative research to 

further develop, evaluate or 

commercialize codon-optimized MUT 

constructs. For collaboration 

opportunities, please contact Claire T. 

Driscoll at cdriscoll@mail.nih.gov. 

Dated: October 28, 2014. 

Richard U. Rodriguez, 

Acting Director, Office of Technology 

Transfer, National Institutes of Health. 

[FR Doc. 2014–25874 Filed 10–30–14; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Environmental 

Health Sciences; Notice of Closed 

Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Environmental Health Sciences Special 

Emphasis Panel; Review of NIEHS R13 

Conference Grant Applications. 

Date: November 24, 2014. 

Time: 12:00 p.m. to 4:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institute of Environmental 

Health Sciences, Keystone Building, 

Conference Room 3118, 530 Davis Drive, 

Research Triangle Park, NC 27709, 

(Telephone Conference Call). 

Contact Person: Janice B. Allen, Ph.D., 

Scientific Review Officer, Scientific Review 

Branch, Division of Extramural Research and 

Training, Nat. Institute of Environmental 

Health Science, P.O. Box 12233, MD EC–30/ 

Room 3170 B, Research Triangle Park, NC 

27709, 919/541–7556. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.115, Biometry and Risk 

Estimation—Health Risks from 

Environmental Exposures; 93.142, NIEHS 

Hazardous Waste Worker Health and Safety 

Training; 93.143, NIEHS Superfund 

Hazardous Substances—Basic Research and 

Education; 93.894, Resources and Manpower 

Development in the Environmental Health 

Sciences; 93.113, Biological Response to 

Environmental Health Hazards; 93.114, 

Applied Toxicological Research and Testing, 

National Institutes of Health, HHS) 

Dated: October 24, 2014. 

Carolyn Baum, 

Program Analyst, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2014–25873 Filed 10–30–14; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HOMELAND 

SECURITY 

Office of the Secretary 

[Docket No. DHS–2014–0053] 

Privacy Act of 1974; Department of 

Homeland Security/United States 

Coast Guard—010 Physical Disability 

Evaluation System Files System of 

Records 

AGENCY: Privacy Office, Department of 

Homeland Security. 

ACTION: Notice of Privacy Act System of 

Records. 

SUMMARY: In accordance with the 

Privacy Act of 1974, the Department of 

Homeland Security proposes to update 

and reissue a current Department of 

Homeland Security system of records 

titled, ‘‘Department of Homeland 

Security/United States Coast Guard 

Physical Disability Evaluation System 

Files System of Records.’’ This system 

of records allows the Department of 

Homeland Security/United States Coast 

Guard to collect and preserve the 

records regarding physical disability 

evaluation proceedings. As a result of 

the biennial review of this system, the 

system manager and address category 

has been updated. This updated system 

will be included in the Department of 

Homeland Security’s inventory of 

record systems. 

DATES: Submit comments on or before 

December 1, 2014. This updated system 

will be effective December 1, 2014. 

ADDRESSES: You may submit comments, 

identified by docket number DHS– 

2014–0053 by one of the following 

methods: 

• Federal e-Rulemaking Portal: http:// 

www.regulations.gov. Follow the 

instructions for submitting comments. 

• Fax: 202–343–4010. 

• Mail: Karen L. Neuman, Chief 

Privacy Officer, Privacy Office, 

Department of Homeland Security, 

Washington, DC 20528. 

Instructions: All submissions received 

must include the agency name and 

docket number for this rulemaking. All 

comments received will be posted 

without change to http://

www.regulations.gov, including any 

personal information provided. 

Docket: For access to the docket to 

read background documents or 

comments received, please visit http:// 

www.regulations.gov. 

FOR FURTHER INFORMATION CONTACT: For 

general questions, please contact: 

Marilyn Scott-Perez (202–475–3515), 

Privacy Officer, Commandant (CG–61), 

United States Coast Guard, Mail Stop 


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