Exhibit 10.68**SEVENTH AMENDMENT TO LEASE**     THIS SEVENTH AMENDMENT TO LEASE (this “Amendment”) is entered into as of this23rd day of January, 2006, by and between BMR-675 WEST KENDALL STREET LLC, a Delawarelimited liability company (“Landlord,” as successor-in-interest to Kendall Square, LLC, aDelaware limited liability company (“Original Landlord”)), and VERTEX PHARMACEUTICALSINCORPORATED (“Tenant”).**RECITALS**     A. WHEREAS, Original Landlord and Tenant entered into that certain Lease dated as of January18, 2001 (as the same has been amended, supplemented or otherwise modified from time to time, the“Lease”), whereby Tenant leases certain premises (the “Premises”) from Landlord at675 West Kendall Street in Cambridge, Massachusetts (the “Building”);     B. WHEREAS, Tenant has requested that Landlord extend the required completion dates for thePhase IB Work and the Phase II Work; and     C. WHEREAS, Landlord and Tenant desire to modify and amend the Lease only in the respects andon the conditions hereinafter stated.**AGREEMENT**     NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained hereinand for other good and valuable consideration, the receipt and sufficiency of which are herebyacknowledged, and intending to be legally bound, agree as follows:     1. Definitions. For purposes of this Amendment, capitalized terms shall have themeanings ascribed to them in the Lease unless otherwise defined herein.     2. Amendment of Completion Dates. The two references to “February 1, 2006” in thenext to last paragraph of Section 3.2.1 of the Lease, as previously amended, are hereby changed to“June 30, 2006.”     3. Broker. Tenant represents and warrants that it has not dealt with any broker oragent in the negotiation for or the obtaining of this Amendment and agrees to indemnify, defend andhold Landlord harmless from any and all cost or liability for compensation claimed by any suchbroker or agent employed or engaged by it or claiming to have been employed or engaged by it.     4. Effect of Amendment. Except as modified by this Amendment, the Lease and all thecovenants, agreements, terms, provisions and conditions thereof shall remain in full force andeffect and are hereby ratified and affirmed. The covenants, agreements, terms, provisions andconditions contained in this Amendment shall bind and inure to the benefit of the parties heretoand their respective successors and,except as otherwise provided in the Lease, their respective assigns. In the
 

 
event of anyconflict between the terms contained in this Amendment and the Lease, the terms herein containedshall supersede and control the obligations and liabilities of the parties.     5. Miscellaneous. This Amendment becomes effective only upon execution and deliveryhereof by Landlord and Tenant. The captions of the paragraphs and subparagraphs in this Amendmentare inserted and included solely for convenience and shall not be considered or given any effect inconstruing the provisions hereof. All exhibits hereto are incorporated herein by reference.     6. Counterparts. This Amendment may be executed in one or more counterparts that,when taken together, shall constitute one original.     7. Consent of Surety. The Landlord, in its capacity as surety under that certainAgreement of Surety Indemnity dated as of September 16, 2003 (as the same has been amended,supplemented or otherwise modified from time to time), by execution of this Amendment herebyconsents to this Amendment.[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]
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     IN WITNESS WHEREOF, Landlord and Tenant have hereunto set their hands as of the date and yearfirst above written, and acknowledge that they possess the requisite authority to enter into thistransaction and to execute this Amendment.       LANDLORD:       BMR-675 WEST KENDALL STREET LLC,  a Delaware limited liability company       By: /s/ GARY A. KREITZER       Name: Gary A. Kreitzer  Title: Executive Vice President       TENANT:       VERTEX PHARMACEUTICALS INCORPORATED       By: /s/ KENNETH S. BOGER       Name: Kenneth S. Boger  Title: Senior Vice President and General Counsel