Prepared and filed by St Ives Burrups


Exhibit 10.12F







	FIFTH AMENDMENT TO LEASE



THIS
  FIFTH AMENDMENT TO LEASE dated this 14 day of April, 1999, by and between
  Salt Lake Research Associates, LP, a New Mexico Limited Partnership, hereinafter
  referred to as Landlord, and NPS Pharmaceuticals Inc., a Delaware Corporation,
  hereinafter referred to as Tenant, for premises located at 420 Chipeta Way,
  Suites 20200 and 20240; and premises located at 410 Chipeta Way, Suite 10219,
  Salt Lake City, Utah 84108.


	RECITALS



WHEREAS,
  under that certain lease dated June 3, 1994 and as Amended on May 14, 1995,
  September 11, 1996, March 6, 1997 and September 22, 1998 (collectively the “Lease”),
  the Tenant presently occupies space (the “Premises”) at 420 Chipeta
  Way, Salt Lake City, Utah; and



WHEREAS,
  it is Tenant’s desire to expand the Leased Premises and Rentable Area
  (the “Premises”) as noted on Exhibit “A” ; and



NOW
  THEREFORE, in consideration of the mutual covenants and agreements herein
  contained and for other good and valuable consideration, the receipt and sufficiency
  of which are hereby acknowledged, Landlord and Tenant hereby covenant and agree
  as follows:


	 	1.	Section 2. Leased
      Premises and Rentable Area. This Section shall be adjusted as follows:
      Effective on or about June 1, 1999, Tenant shall expand its Primary Space
      to include space presently occupied by University
      of Utah Hospital Homecare (“Homecare”) containing 1,610 rentable
      square feet (the “Expansion Space”) for a total of 56,056 rentable
      square feet. Tenant hereby accepts the Expansion Space in its “as
      is” condition.
	 	 	 
	 	2.	Section 5. Rent
      of the Lease is amended to provide that during the Extended Term hereof
      Tenant shall pay to Landlord for their Leased Premises, in addition to any
      other charge to be paid by Tenant under the “Lease”, $11.00
      per rentable square foot as monthly rent for the first year. On each anniversary
      date of the extended term, rent shall increase by 2.75% and shall be paid
      as follows: 
	 	 	 
	 	 	Year	Month	Annual
	 	 	  6/1/99 –
      9/30/99	$ 48,092.58	$577,111.00
	 	 	10/1/99 – 9/30/00	$ 51,384.67	$616.616.00
	 	 	10/1/00– 9/30/01	$ 52,797.75	$633,572.94
	 	 	10/1/01– 9/30/02	$ 54,249.68	$650,996.20
	 	 	10/1/02– 9/30/03	$ 55,741.55	$668,898.59
	 	 	10/1/03– 9/30/04	$ 57,274.44	$687,293.30


1






	 	3.	Section 14. Alterations.
      Tenant shall be responsible for the installation, completion and the cost
      of all action required to comply with any and all statutes, rules, regulations,
      zoning codes, building codes and the requirements of the Americans with
      Disabilities Act of 1990 (the “ADA”). Tenant shall not reconfigure
      the common area corridors in any manner without obtaining Landlord’s
      prior written approval.
	 	 	 
	 	4.	Brokerage. Landlord and
      Tenant each warrant to the other that it has not dealt with any broker or
      agent in connection with the negotiation or execution of this Lease except
      Landlord’s Broker Grubb & Ellis/Utah Realty and Tenant’s
      Broker GVA Business Properties Group. Tenant and Landlord shall each indemnify
      the other against all costs, expenses, attorneys’ fees, and other
      liability for commissions or other compensation claimed by any broker or
      agent claiming the same by, through, or under the indemnifying party. Any
      and all commissions payable to Tenant’s Broker shall be paid by Tenant
      and Tenant indemnifies Landlord against all costs, expenses, attorneys’
      fees, and other liability for commissions or other compensation claimed
      by Tenant’s Broker.


Except as modified herein, all terms and conditions of the Lease, as amended, shall remain in full force and effect.

	LANDLORD:
	TENANT:

	 	 
	SALT LAKE RESEARCH PARK
        ASSOCIATES, LIMITED PARTNERSHIP

        By: BGK Realty, Inc., its general partner
	 NPS
        PHARMACEUTICAL INC.

	 	 
	By:  /s/  Cheryl
        S. Willoughby
	By: /s/  Robert K. [Illegible]
	               Cheryl
      S. Willoughby	              Robert
      K. [Illegible]
	Title: Senior Vice President
	Title: Vice President, Finance


2



 




EXHIBIT “A”




3