Federal Register / Vol. 79, No. 211 / Friday, October 31, 2014 / Notices 64809 

protein and fat by-products resulting in 

seizures, strokes, and chronic kidney 

failure. A significant portion of MMA 

cases stem from a deficiency in a key 

mitochondrial enzyme, methylmalonylCoA mutase (MUT), required to break 

down amino acids and lipids. Currently, 

there are no treatments for MMA and 

the disease is managed primarily with 

dietary restriction of amino acid 

precursors and liver-kidney 

transplantation in severe cases. 

The present invention describes a 

synthetic codon-optimized MUT gene 

(co-MUT) that improves expression of 

human methylmalonyl-CoA mutase. A 

series of novel gene therapy vectors 

containing co-MUT rescued MMA mice 

from lethality and lowered levels of 

methylmalonic acid in the blood. 

Results of pre-clinical efficacy studies 

demonstrate a promising therapy for 

MMA and other renal-associated 

disorders. 

Potential Commercial Applications: 

• The co-MUT transgene could be 

used to treat MMA patients. 

• In addition, it could be used to 

produce MUT in vitro for MMA enzyme 

replacement therapy. 

Competitive Advantages: co-MUT 

transgene could be used through nonviral and viral gene delivery. 

Development Stage: 

• In vitro data available 

• In vivo data available (animal) 

Inventors: Charles P. Venditti and 

Randy J. Chandler (NHGRI) 

Intellectual Property: HHS Reference 

No. E–243–2012/0— 

• U.S. Provisional Application No. 

61/792,081 filed 15 March 2013 

• PCT Application No. PCT/US2014/ 

028045 filed 14 March 2014 

Licensing Contact: Vince Contreras, 

Ph.D.; 301–435–4711; vince.contreras@

nih.gov 

Collaborative Research Opportunity: 

The Organic Acid Research Section at 

the National Human Genome Research 

Institute is seeking statements of 

capability or interest from parties 

interested in collaborative research to 

further develop, evaluate or 

commercialize codon-optimized MUT 

constructs. For collaboration 

opportunities, please contact Claire T. 

Driscoll at cdriscoll@mail.nih.gov. 

Dated: October 28, 2014. 

Richard U. Rodriguez, 

Acting Director, Office of Technology 

Transfer, National Institutes of Health. 

[FR Doc. 2014–25874 Filed 10–30–14; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Environmental 

Health Sciences; Notice of Closed 

Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Environmental Health Sciences Special 

Emphasis Panel; Review of NIEHS R13 

Conference Grant Applications. 

Date: November 24, 2014. 

Time: 12:00 p.m. to 4:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institute of Environmental 

Health Sciences, Keystone Building, 

Conference Room 3118, 530 Davis Drive, 

Research Triangle Park, NC 27709, 

(Telephone Conference Call). 

Contact Person: Janice B. Allen, Ph.D., 

Scientific Review Officer, Scientific Review 

Branch, Division of Extramural Research and 

Training, Nat. Institute of Environmental 

Health Science, P.O. Box 12233, MD EC–30/ 

Room 3170 B, Research Triangle Park, NC 

27709, 919/541–7556. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.115, Biometry and Risk 

Estimation—Health Risks from 

Environmental Exposures; 93.142, NIEHS 

Hazardous Waste Worker Health and Safety 

Training; 93.143, NIEHS Superfund 

Hazardous Substances—Basic Research and 

Education; 93.894, Resources and Manpower 

Development in the Environmental Health 

Sciences; 93.113, Biological Response to 

Environmental Health Hazards; 93.114, 

Applied Toxicological Research and Testing, 

National Institutes of Health, HHS) 

Dated: October 24, 2014. 

Carolyn Baum, 

Program Analyst, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2014–25873 Filed 10–30–14; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HOMELAND 

SECURITY 

Office of the Secretary 

[Docket No. DHS–2014–0053] 

Privacy Act of 1974; Department of 

Homeland Security/United States 

Coast Guard—010 Physical Disability 

Evaluation System Files System of 

Records 

AGENCY: Privacy Office, Department of 

Homeland Security. 

ACTION: Notice of Privacy Act System of 

Records. 

SUMMARY: In accordance with the 

Privacy Act of 1974, the Department of 

Homeland Security proposes to update 

and reissue a current Department of 

Homeland Security system of records 

titled, ‘‘Department of Homeland 

Security/United States Coast Guard 

Physical Disability Evaluation System 

Files System of Records.’’ This system 

of records allows the Department of 

Homeland Security/United States Coast 

Guard to collect and preserve the 

records regarding physical disability 

evaluation proceedings. As a result of 

the biennial review of this system, the 

system manager and address category 

has been updated. This updated system 

will be included in the Department of 

Homeland Security’s inventory of 

record systems. 

DATES: Submit comments on or before 

December 1, 2014. This updated system 

will be effective December 1, 2014. 

ADDRESSES: You may submit comments, 

identified by docket number DHS– 

2014–0053 by one of the following 

methods: 

• Federal e-Rulemaking Portal: http:// 

www.regulations.gov. Follow the 

instructions for submitting comments. 

• Fax: 202–343–4010. 

• Mail: Karen L. Neuman, Chief 

Privacy Officer, Privacy Office, 

Department of Homeland Security, 

Washington, DC 20528. 

Instructions: All submissions received 

must include the agency name and 

docket number for this rulemaking. All 

comments received will be posted 

without change to http://

www.regulations.gov, including any 

personal information provided. 

Docket: For access to the docket to 

read background documents or 

comments received, please visit http:// 

www.regulations.gov. 

FOR FURTHER INFORMATION CONTACT: For 

general questions, please contact: 

Marilyn Scott-Perez (202–475–3515), 

Privacy Officer, Commandant (CG–61), 

United States Coast Guard, Mail Stop 


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