Prepared and filed by St Ives Burrups


Exhibit 10.12b






 1st Amendment

 AMENDMENT TO LEASE –
  EXPANSION 

 THIS AMENDMENT is executed at Salt Lake
  City, Utah between Salt Lake Research Park Associates a New Mexico Limited
  Partnership by BGK Realty Inc, a Delaware Corporation, as General Partner,
  Landlord, and NPS Pharmaceuticals, Inc., a Delaware Corporation, Tenant,
  for the premises located at 420 Chipeta Way Suite 240, Salt Lake City, Utah
  84108. 

 Landlord and Tenant being parties to that
  certain Lease dated June 3, 1994, hereby express their mutual
  desire and intent to increase the rentable area of the Leased Premises by 3,341
  square feet (hereafter referred to as “Expansion Space”) effective
  December 1, 1995, and amend by this writing those terms, covenants and
  conditions as hereinafter provided. 

AMENDMENTS 

	“2	LEASED PREMISES AND RENTABLE AREA”
      shall hereafter additionally provide as follows: That portion of the 1st
      floor of the building more fully shown on the Floor Plan attached hereto
      as Schedule 1 - Expansion Space. The Rentable Area of the Premises shall
      hereafter mean: approximately 33.617 square feet.
	 	 
	“5 	RENT” shall hereafter additionally
      provide as follows: The annual Rent for the Expansion Space shall be Thirty
      Three Thousand Four Hundred Eight and No/100 Dollars ($33,408.00) per
      annum, payable in monthly installments in the amount of Two Thousand
      Seven Hundred Eighty Four and No/100 Dollars ($2,784.00) in lawful money
      of the United States.


Tenant's Proportionate Share shall be adjusted
  accordingly to reflect the increase in the rentable square feet of the Premises.

Except as modified herein, all terms and conditions
  of the Office Lease shall remain in full force
  and effect.

	Landlord:
	Tenant:

	 	 
	Salt Lake Research
        Park Associates, a

      New Mexico Limited Partnership
	NPS
        Pharmaceuticals, Inc., a

      Delaware Corporation

	 	 
	By: BGK Realty, Inc.
	 
	 	 
	Its: General Partner
	 
	 	 
	By: /s/ [Illegible]	By: /s/ Robert K. [Illegible]
	Title: Senior Vice President	Title: Vice President, Finance
	Execution Date: May 12, 1998	Execution Date: May 7, 1995









SCHEDULE I

  EXPANSION SPACE





 





  
 ADDENDUM 

 1.     Agency
  Disclosure: At the signing of this agreement, Wallace Associates Business
  Properties Group's agent Debra A. Ekins represents Landlord and Tenant represents
  themselves. Tenant and Landlord confirm that prior to signing this agreement
  written disclosure of the agency relationship(s) was provided. 

 2.     Hazardous
  Materials Disclaimer: The real estate salespersons and brokers in this transaction
  have no expertise with respect to toxic wastes, hazardous materials or undesirable
  substances. Unless the Landlord can provide definitive representation regarding
  the existence or nonexistence of toxic wastes, hazardous materials or undesirable
  substances on the Property then inspections of the Property by qualified experts
  alone can determine whether or not there are any current or potentially toxic
  wastes, hazardous materials or undesirable substances in or on the Property.
  Landlord and Tenant warrant that the real estate salespersons and brokers in
  this transaction have not made any representations, either express or implied,
  regarding the existence or nonexistence of toxic wastes, hazardous materials,
  or undesirable substances in or on the Property. If deemed necessary, it is
  the responsibility of Landlord and Tenant to retain qualified experts to deal
  with the detection and correction of such matters. Both the Tenant and the Landlord
  will hold the real estate sales persons and brokers harmless.

 

	LANDLORD
	TENANT:

	 	 
	Salt Lake Research
        Park Associates, a

      New Mexico Limited Partnership
	NPS
        Pharmaceuticals, Inc., a

      Delaware Corporation

	 	 
	By: BGK Realty, Inc.
	 
	 	 
	Its: General Partner
	 
	 	 
	By:    ____________________	By: Robert K. [Illegible]
	Title:  ____________________	Title: Vice President, Finance
	Date: ____________________	 Date: May 7, 1995