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                                                                   Exhibit 10.34

                                    AMENDMENT

       THIS AMENDMENT is made as of the 19th day of December, 2002, between
General Electric Capital Corporation ("Secured Party") and Neose Technologies,
Inc. ("Debtor") in connection with that certain Master Security Agreement, dated
as of December 19, 2002 ("Agreement"). The terms of this Amendment are hereby
incorporated into the Agreement as though fully set forth therein. Section
references below refer to the section numbers of the Agreement. The Agreement is
hereby amended as follows:

        2. REPRESENTATIONS, WARRANTIES AND COVENANTS OF DEBTOR.

        New Subsection (l) is hereby added to Section 2 and hereby reads as
        follows:

        "(l) Secured Party will acquire by the terms of this Agreement good
        title to the Collateral under any and all Collateral Schedules free from
        all liens and encumbrances whatsoever and the Collateral has been
        delivered to Debtor in good order and condition, and conforms to the
        specifications, requirements and standards applicable thereto; and "

        New Subsection (m) is hereby added to Section 2 and hereby reads as
        follows:

        "The amount financed as set forth in the Collateral Schedules is the
        correct original equipment cost that Debtor paid to the vendors listed
        in the Collateral Schedules."

        5. REPORTS.

        Subsection (b) is hereby amended and restated as follows:

        "(b) Debtor will deliver to Secured Party financial statements as
        follows. If Debtor is a privately held company, then Debtor agrees to
        provide monthly financial statements, certified by Debtor's president or
        chief financial officer including a balance sheet, statement of
        operations and cash flow statement within 30 days of each month end and
        its complete audited annual financial statements, certified by a
        recognized firm of certified public accountants, within 120 days of
        fiscal year end or at such time as Debtor's Board of Directors receives
        the audit. If Debtor is a publicly held company, then Debtor agrees to
        provide quarterly unaudited statements and annual audited statements,
        such annual statements being certified by a recognized firm of certified
        public accountants, within 10 days after the statements are provided to
        the Securities and Exchange Commission ("SEC"). All such statements are
        to be prepared using generally accepted accounting principles ("GAAP")
        and, if Debtor is a publicly held company, are to be in compliance with
        SEC requirements."

        7. DEFAULT AND REMEDIES.

        Subsection (a) is hereby amended and restated as follows:

        "(a) Debtor shall be in default under this Agreement and each of the
        other Debt Documents if:

        (i)  Debtor breaches its obligation to pay when due any installment or
        other amount due under any of the Debt Documents;

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        (ii)   Debtor, without the prior written consent of Secured Party,
        attempts to or does sell, rent, lease, license, mortgage, grant a
        security interest in, or otherwise transfer or encumber (except for
        Permitted Liens) any of the Collateral;

        (iii)  Debtor breaches any of its insurance obligations under Section 4;

        (iv)   Debtor breaches any of its other obligations under any of the
        Debt Documents and fails to cure that breach within thirty (30) days
        after written notice from Secured Party;

        (v)    Any warranty, representation or statement made by Debtor in any
        of the Debt Documents or otherwise in connection with any of the
        Indebtedness shall be false or misleading in any material respect;

        (vi)   Any of the Collateral is subjected to attachment, execution,
        levy, seizure or confiscation in any legal proceeding or otherwise, or
        if any legal or administrative proceeding is commenced against Debtor or
        any of the Collateral, which in the good faith judgment of Secured Party
        subjects any of the Collateral to a material risk of attachment,
        execution, levy, seizure or confiscation and no bond is posted or
        protective order obtained to negate such risk;

        (vii)  Debtor breaches or is in default under any other agreement
        between Debtor and Secured Party;

        (viii) Debtor or any guarantor or other obligor for any of the
        Indebtedness (collectively "Guarantor") dissolves, terminates its
        existence, becomes insolvent or ceases to do business as a going
        concern;

        (ix)   If Debtor or any Guarantor is a natural person, Debtor or any
        such Guarantor dies or becomes incompetent;

        (x)    A receiver is appointed for all or of any part of the property of
        Debtor or any Guarantor, or Debtor or any Guarantor makes any assignment
        for the benefit of creditors;

        (xi)   Debtor or any Guarantor files a petition under any bankruptcy,
        insolvency or similar law, or any such petition is filed against Debtor
        or any Guarantor and is not dismissed within forty-five (45) days;

        (xii)  Debtor's improper filing of an amendment or termination statement
        relating to a filed financing statement describing the Collateral; or

        (xiii) Debtor defaults under any other material obligation for (A)
        borrowed money, (B) the deferred purchase price of property or (C)
        payments due under any other material equipment lease agreement.

        (xiv)  At any time during the term of this Agreement Debtor sells more
        than 50% of its interest in the company to another corporation or
        business or all or substantially all of its assets without Secured
        Party's prior written consent."

        TERMS USED, BUT NOT OTHERWISE DEFINED HEREIN SHALL HAVE THE MEANINGS
GIVEN TO THEM IN THE AGREEMENT. EXCEPT AS EXPRESSLY AMENDED

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HEREBY, THE AGREEMENT SHALL REMAIN IN FULL FORCE AND EFFECT. IF THERE IS ANY
CONFLICT BETWEEN THE PROVISIONS OF THE AGREEMENT AND THIS AMENDMENT, THEN THIS
AMENDMENT SHALL CONTROL.

       IN WITNESS WHEREOF, the parties hereto have executed this Amendment
simultaneously with the Agreement by signature of their respective authorized
representative set forth below.

General Electric Capital Corporation        Neose Technologies, Inc.

By:  /s/ John Edel                          By:  /s/ A. Brian Davis
   ---------------------------------           ---------------------------------

Name:  John Edel                            Name:  A. Brian Davis
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Title:  Senior Vice President               Title:  Vice President, Finance
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