Exhibit 31

                                 CERTIFICATION

                                       OF

              CHIEF EXECUTIVE OFFICER AND CHIEF FINANCIAL OFFICER

I, C.E. "Rick" Strattan, certify that:

1.   I have reviewed this annual report (Form 10-KSB) of CTD Holdings, Inc.;

2.   Based on my knowledge, this report does not contain any untrue statement of
     a material  fact or omit to state a  material  fact  necessary  to make the
     statements made, in light of the circumstances  under which such statements
     were made,  not  misleading  with  respect  to the  period  covered by this
     report;

3.   Based on my  knowledge,  the  financial  statements,  and  other  financial
     information  included  in  this  report,  fairly  present  in all  material
     respects the financial  condition,  results of operations and cash flows of
     the registrant as of, and for, the periods presented in this report;

4.   I am responsible for establishing and maintaining  disclosure  controls and
     procedures  (as defined in Exchange Act Rules  13a-15(e) and 15d-15(e)) and
     internal  controls  over  financial  reporting  (as defined in Exchange Act
     Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

     a.  Designed  such  disclosure  controls  and  procedures,  or caused  such
     disclosure controls and procedures to be designed under my supervision, to
     ensure that material information relating to the registrant,  including its
     consolidated  subsidiaries,  is made  known to me by  others  within  those
     entities,  particularly  during the  period in which  this  report is being
     prepared;

     b. Designed such internal control over financial reporting,  or caused such
     internal  control  over  financial  reporting  to  be  designed  under  our
     supervision,  to provide reasonable  assurance regarding the reliability of
     financial  reporting  and  the  preparation  of  financial  statements  for
     external  purposes  in  accordance  with  generally   accepted   accounting
     principles;

     c. Evaluated the effectiveness of the registrant's  disclosure controls and
     procedures  and  presented  in  this  report  my   conclusions   about  the
     effectiveness of the disclosure  controls and procedures,  as of the end of
     the  period  covered  by  this  report  based  on such  evaluation;  and d.
     Disclosed in this report any change in the  registrant's  internal  control
     over financial  reporting that occurred during the registrant's most recent
     fiscal  quarter (the  registrant's  fourth fiscal quarter in the case of an
     annual report) that has  materially  affected,  or is reasonably  likely to
     materially  affect,  the  registrant's   internal  control  over  financial
     reporting; and

5.   I have disclosed,  based on my most recent  evaluation of internal  control
     over  financial  reporting,  to the  registrant's  auditors  and the  audit
     committee of the registrant's board of directors (or persons performing the
     equivalent functions):

     a. All significant  deficiencies  and material  weaknesses in the design or
     operation of internal control over financial reporting which are reasonably
     likely to adversely  affect the  registrant's  ability to record,  process,
     summarize and report financial information; and

     b. Any fraud,  whether or not material,  that involves  management or other
     employees who have a significant role in the registrant's  internal control
     over financial reporting.

Date:  January 8, 2009

/s/ C.E. "Rick" Strattan
__________________________________
C.E. "RICK" STRATTAN
Chief Executive Officer
Chief Financial Officer