# Patent

## Title
Active compound combinations comprising specific tetramic acid derivatives

## Abstract

The invention provides combinations of insecticides/acaricides and herbicides comprising an effective amount of components (A) and (B), where component (A) is one or more of the tetramic acid derivatives listed in the description, and (B) one or more herbicides from the group of the herbicides likewise listed in the description, where the combinations may optionally additionally comprise crop plant compatibility-increasing substances (safeners).
The invention also relates to the use of the combinations for controlling animal pests and unwanted vegetation and to the corresponding methods.

## Background
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a §371 National Stage Application of PCT/EP2012/065469, filed Aug. 7, 2012, which claims priority to 61/521,827, filed Aug. 10, 2011.
BACKGROUND
1. Field of Invention
The invention is in the technical field of crop protection compositions which can be used simultaneously against harmful plants and animal pests such as insects/spider mites, for example in crop plants, and comprise, as active compounds, a combination of at least one insecticide/acaricide and at least one herbicide and, if appropriate, additionally crop plant compatibility-increasing substances (safeners).
2. Descrition of Related Art
The Co-application of glyphosate plus an insecticide (e.g. Spirotetramat) or fungicides in glyphosate-resistant soybean has been described in Canadian Journal of Plant Science (2012), 92(2), 297-302. Glyphosate tankmixed with e.g. Spirotetramat has no adverse effect on weed control in glyphosate resistant soybean.
WO 98/05638 describes tetramic acid derivatives, their preparation and their use as insecticides/acaricides. The corresponding cis-isomers are described in WO 04/007448.
From WO 07/068428, it is known that the insecticidal/acaricidal activities of tetramic acid derivatives can be improved by adding adjuvants. Also known are the effects of herbicidally active tetramic acid derivatives in combination with other herbicides, for example from WO 06/024411 and WO 09/007014.
The activity of these insecticides/acaricides against animal pests in the crop plants is on a high level; however, it generally depends on the application rate, the formulation in question, the respective animal pests to be controlled, the climatic and soil conditions, etc. A further criterium is the duration of action or the rate of degradation of the insecticide/acaricide. In general, however, there is always a need for methods achieving insecticidal/acaricidal action with a lower active compound application rate. A lower application rate reduces not only the amount of active compound required for application but generally also reduces the amount of formulation auxiliaries required. Both reduce economic expense and improve the ecological compatibility of the insecticide/acaricide treatment.
One way of improving the application profile of an insecticide/acaricide may be to combine the active compound with one or more herbicidally active compounds. However, the combined use of a plurality of active compounds, in particular when insecticides are used together with herbicides, does not infrequently lead to phenomena of physical and biological imcompatibility, for example lacking stability of a coformulation, decomposition of an active compound or antagonism of the active compounds. In contrast, what is desired are combinations of active compounds and/or formulations thereof having a favourable activity profile, high stability and, ideally, synergistically enhanced activity, which permits a reduction of the application rate compared with the individual application of the active compounds to be combined. Likewise advantageous may be a broadening of the activity spectrum, an increased application flexibility and a faster onset of action.
SUMMARY
Surprisingly, it has now been found that certain active compounds from the group of the tetramic acid derivatives in combination with certain structurally different herbicides act together in a particularly favourable manner, for example when used in crop plants suitable for the selective application of the herbicides, which firthermire allow the amount of adjuvants to be reduced and make successive spraying with a herbicide and an insecticide/acaricide unnecessary. This combination offers economical advantages to the user, is ecologically very advantageous and has a positive effect on the water and CO2 balance of the treatment of the crop since one spraying course and thus also the water for preparing the spray liquor is saved, which is advantageous in semiarid regions.
Accordingly, the invention provides combinations of insecticides/acaricides and herbicides comprising an effective amount of components (A) and (B) where

    (A) is one or two insecticides/acaricides from group (A) below which consists of the compounds






(where A1 is emphasized and A2 is likewise emphasized),

and

    (B) is one or more herbicides from the list of herbicides and plant growth regulators below:
    acetochlor, acibenzolar, acibenzolar-S-methyl, acifluorfen, acifluorfen-sodium, aclonifen, alachlor, allidochlor, alloxydim, alloxydim-sodium, ametryn, amicarbazone, amidochlor, amidosulfuron, aminocyclopyrachlor, aminopyralid, amitrole, ammonium sulphamate, ancymidol, anilofos, asulam, atrazine, azafenidin, azimsulfuron, aziprotryn, beflubutamid, benazolin, benazolin-ethyl, bencarbazone, benfluralin, benfuresate, bensulide, bensulfuron, bensulfuron-methyl, bentazone, benzfendizone, benzobicyclon, benzofenap, benzofluor, benzoylprop, bicyclopyrone, bifenox, bilanafos, bilanafos-sodium, bispyribac, bispyribac-sodium, bromacil, bromobutide, bromofenoxim, bromoxynil, bromuron, buminafos, busoxinone, butachlor, butafenacil, butamifos, butenachlor, butralin, butroxydim, butylate, cafenstrole, carbetamide, carfentrazone, carfentrazone-ethyl, chlomethoxyfen, chloramben, chlorazifop, chlorazifop-butyl, chlorbromuron, chlorbufam, chlorfenac, chlorfenac-sodium, chlorfenprop, chlorflurenol, chlorflurenol-methyl, chloridazon, chlorimuron, chlorimuron-ethyl, chlormequat chloride, chlornitrofen, chlorophthalim, chlorthal-dimethyl, chlorotoluron, chlorsulfuron, cinidon, cinidon-ethyl, cinmethylin, cinosulfuron, clethodim, clodinafop, clodinafop-propargyl, clofencet, clomazone, clomeprop, cloprop, clopyralid, cloransulam, cloransulam-methyl, cumyluron, cyanamide, cyanazine, cyclanilide, cycloate, cyclosulfamuron, cycloxydim, cycluron, cyhalofop, cyhalofop-butyl, cyperquat, cyprazine, cyprazole, 2,4-D, 2,4-DB, daimuron/dymron, dalapon, daminozide, dazomet, n-decanol, desmedipham, desmetryn, detosyl-pyrazolate (DTP), diallate, dicamba, dichlobenil, dichlorprop, dichlorprop-P, diclofop, diclofop-methyl, diclofop-P-methyl, diclosulam, diethatyl, diethatyl-ethyl, difenoxuron, difenzoquat, diflufenican, diflufenzopyr, diflufenzopyr-sodium, dikegulac-sodium, dimefuron, dimepiperate, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, dimethipin, dimetrasulfuron, dinitramine, dinoseb, dinoterb, diphenamid, dipropetryn, diquat, diquat dibromide, dithiopyr, diuron, DNOC, eglinazine-ethyl, endothal, EPTC, esprocarb, ethalfluralin, ethametsulfuron, ethametsulfuron-methyl, ethephon, ethidimuron, ethiozin, ethofumesate, ethoxyfen, ethoxyfen-ethyl, ethoxysulfuron, etobenzanid, F-5331, i.e. N-[2-chloro-4-fluoro-5-[4-(3-fluoropropyl)-4,5-dihydro-5-oxo-1H-tetrazol-1-yl]phenyl]ethanesulphonamide, F-7967, i.e. 3-[7-chloro-5-fluoro-2-(trifluoromethyl)-1H-benzimidazol-4-yl]-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, fenoprop, fenoxaprop, fenoxaprop-P, fenoxaprop-ethyl, fenoxaprop-P-ethyl, fenoxasulfone, fentrazamide, fenuron, flamprop, flamprop-M-isopropyl, flamprop-M-methyl, flazasulfuron, florasulam, fluazifop, fluazifop-P, fluazifop-butyl, fluazifop-P-butyl, fluazolate, flucarbazone, flucarbazone-sodium, flucetosulfuron, fluchloralin, flufenacet (thiafluamide), flufenpyr, flufenpyr-ethyl, flumetralin, flumetsulam, flumiclorac, flumiclorac-pentyl, flumioxazin, flumipropyn, fluometuron, fluorodifen, fluoroglycofen, fluoroglycofen-ethyl, flupoxam, flupropacil, flupropanate, flupyrsulfuron, flupyrsulfuron-methyl-sodium, flurenol, flurenol-butyl, fluridone, flurochloridone, fluroxypyr, fluroxypyr-meptyl, flurprimidol, flurtamone, fluthiacet, fluthiacet-methyl, fluthiamide, fomesafen, foramsulfuron, forchlorfenuron, fosamine, furyloxyfen, gibberellic acid, glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-ammonium, glufosinate-P-sodium, glyphosate, glyphosate-isopropylammonium, H-9201, i.e. O-(2,4-dimethyl-6-nitrophenyl) O-ethyl isopropylphosphoramidothioate, halosafen, halosulfuron, halosulfuron-methyl, haloxyfop, haloxyfop-P, haloxyfop-ethoxyethyl, haloxyfop-P-ethoxyethyl, haloxyfop-methyl, haloxyfop-P-methyl, hexazinone, HW-02, i.e. 1-(dimethoxyphosphoryl)ethyl (2,4-dichlorphenoxy)acetate, imazamethabenz, imazamethabenz-methyl, imazamox, imazamox-ammonium, imazapic, imazapyr, imazapyr-isopropylammonium, imazaquin, imazaquin-ammonium, imazethapyr, imazethapyr-ammonium, imazosulfuron, inabenfide, indanofan, indaziflam, indoleacetic acid (IAA), 4-indol-3-ylbutyric acid (IBA), iodosulfuron, iodosulfuron-methyl-sodium, ioxynil, ipfencarbazone, isocarbamid, isopropalin, isoproturon, isouron, isoxaben, isoxachlortole, isoxaflutole, isoxapyrifop, KUH-043, i.e. 3-({[5-(difluoromethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}-sulphonyl)-5,5-dimethyl-4,5-dihydro-1,2-oxazole, karbutilate, ketospiradox, lactofen, lenacil, linuron, maleic hydrazide, MCPA, MCPB, MCPB-methyl, -ethyl and -sodium, mecoprop, mecoprop-sodium, mecoprop-butotyl, mecoprop-P-butotyl, mecoprop-P-dimethylammonium, mecoprop-P-2-ethylhexyl, mecoprop-P-potassium, mefenacet, mefluidide, mepiquat chloride, mesosulfuron, mesosulfuron-methyl, mesotrione, methabenzthiazuron, metam, metamifop, metamitron, metazachlor, metazasulfuron, methazole, methiopyrsulfuron, methiozolin, methoxyphenone, methyldymron, 1-methylcyclopropene, methyl isothiocyanate, metobenzuron, metobromuron, metolachlor, S-metolachlor, metosulam, metoxuron, metribuzin, metsulfuron, metsulfuron-methyl, molinate, monalide, monocarbamide, monocarbamide dihydrogensulphate, monolinuron, monosulfuron, monosulfuron esters, monuron, MT-128, i.e. 6-chloro-N-[(2E)-3-chloroprop-2-en-1-yl]-5-methyl-N-phenylpyridazine-3-amine, MT-5950, i.e. N-[3-chloro-4-(1-methylethyl)phenyl]-2-methylpentanamide, NGGC-011, naproanilide, napropamide, naptalam, NC-310, i.e. 4-(2,4-dichlorobenzoyl)-1-methyl-5-benzyloxypyrazole, neburon, nicosulfuron, nipyraclofen, nitralin, nitrofen, nitrophenolate-sodium (isomer mixture), nitrofluorfen, nonanoic acid, norflurazon, orbencarb, orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxasulfuron, oxaziclomefone, oxyfluorfen, paclobutrazol, paraquat, paraquat dichloride, pelargonic acid (nonanoic acid), pendimethalin, pendralin, penoxsulam, pentanochlor, pentoxazone, perfluidone, pethoxamid, phenisopham, phenmedipham, phenmedipham-ethyl, picloram, picolinafen, pinoxaden, piperophos, pirifenop, pirifenop-butyl, pretilachlor, primisulfuron, primisulfuron-methyl, probenazole, profluazol, procyazine, prodiamine, prifluraline, profoxydim, prohexadione, prohexadione-calcium, prohydrojasmone, prometon, prometryn, propachlor, propanil, propaquizafop, propazine, propham, propisochlor, propoxycarbazone, propoxycarbazone-sodium, propyrisulfuron, propyzamide, prosulfalin, prosulfocarb, prosulfuron, prynachlor, pyraclonil, pyraflufen, pyraflufen-ethyl, pyrasulfotole, pyrazolynate (pyrazolate), pyrazosulfuron, pyrazosulfuron-ethyl, pyrazoxyfen, pyribambenz, pyribambenz-isopropyl, pyribambenz-propyl, pyribenzoxim, pyributicarb, pyridafol, pyridate, pyriftalid, pyriminobac, pyriminobac-methyl, pyrimisulfan, pyrithiobac, pyrithiobac-sodium, pyroxasulfone, pyroxsulam, quinclorac, quinmerac, quinoclamine, quizalofop, quizalofop-ethyl, quizalofop-P, quizalofop-P-ethyl, quizalofop-P-tefuryl, rimsulfuron, saflufenacil, secbumeton, sethoxydim, siduron, simazine, simetryn, SN-106279, i.e. methyl (2R)-2-({7-[2-chloro-4-(trifluoromethyl)phenoxy]-2-naphthyl}oxy)propanoate, sulcotrione, sulfallate (CDEC), sulfentrazone, sulfometuron, sulfometuron-methyl, sulfosate (glyphosate-trimesium), sulfosulfuron, SYN-523, SYP-249, i.e. 1-ethoxy-3-methyl-1-oxobut-3-en-2-yl 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate, SYP-300, i.e. 1-[7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]-3-propyl-2-thioxoimidazolidine-4,5-dione, tebutam, tebuthiuron, tecnazene, tefuryltrione, tembotrione, tepraloxydim, terbacil, terbucarb, terbuchlor, terbumeton, terbuthylazine, terbutryn, thenylchlor, thiafluamide, thiazafluron, thiazopyr, thidiazimin, thidiazuron, thiencarbazone, thiencarbazone-methyl, thifensulfuron, thifensulfuron-methyl, thiobencarb, tiocarbazil, topramezone, tralkoxydim, triafamone, triallate, triasulfuron, triaziflam, triazofenamide, tribenuron, tribenuron-methyl, trichloroacetic acid (TCA), triclopyr, tridiphane, trietazine, trifloxysulfuron, trifloxysulfuron-sodium, trifluralin, triflusulfuron, triflusulfuron-methyl, trimeturon, trinexapac, trinexapac-ethyl, tritosulfuron, tsitodef, uniconazole, uniconazole-P, vernolate, ZJ-0862, i.e. 3,4-dichloro-N-{2-[(4,6-dimethoxypyrimidin-2-yl)oxy]benzyl}aniline, and also the compounds below:








DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT
preferably groups (B1) to (B4),


    
    
        group (B-1) comprising herbicides which are predominantly active against monocotyledonous harmful plants, from the group of compounds consisting of (listed by “common name” and a reference, for example “The Pesticide Manual” 13th Ed., British Crop Protection Council 2003, abbreviated “PM”)
    
    
    (B1.1) pinoxaden (WO 99/47525), for example 8-(2,6-diethyl-4-methylphenyl)-1,2,4,5-tetra-hydro-7-oxo-7H-pyrazolo[1,2-d][1,4,5]oxadiazepin-9-yl 2,2-dimethylpropanoate
    (B1.2) diclofop-methyl (PM, pp. 293-295), for example methyl 2-[4-(2,4-dichlorophenoxy)-phenoxy]propanoate
    (B1.3) clodinafop-propargyl (PM, pp. 186-187), for example (R)-(2-propynyl) 2-[4-[(5-chloro-3-fluoro-2-pyridinyl)oxy]phenoxy]propanoate
    (B1.4) cyhalofop-butyl (PM, pp. 229-232), for example (R)-butyl 2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propanoate
    (B1.5) fenoxaprop-P-ethyl (PM, pp. 414-417), for example (R)-ethyl 2-[4-[(6-chloro-2-benzoxa-zolyl)oxy]phenoxy]propanoate
    (B1.6) haloxyfop-P (PM, pp. 52-527) and its esters, for example (R)-methyl 2-[4-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]phenoxy]propanoate
    (B1.7) fluazifop-P-butyl (PM, pp. 444-446), for example (R)-butyl 2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenoxy]propanoate
    (B1.8) quizalofop-P (PM, pp. 876-878) and its esters, for example ethyl 2-[4-(6-chloro-2-quin-oxalinyloxy)phenoxy]propanoate
    (B1.9) sethoxydim (PM, pp. 887-888), for example (+-)-2-[1-(ethoxyimino)butyl]-5-[2-(ethylthio)propyl]-3-hydroxy-2-cyclohexen-1-one
    (B1.10) clethodim (PM, pp. 185-186), for example (E,E)-(+)-2-[1-[[(3-chloro-2-propenyl)oxy]-imino]propyl]-5-[2-(ethylthio)propyl]-3-hydroxy-2-cyclohexen-1-one
    (B1.11) tepraloxydim (PM, pp. 936-937), for example 2-[1-[[[(2E)-3-chloro-2-propenyl]oxy]-imino]propyl]-3-hydroxy-5-(tetrahydro-2H-pyran-4-yl)-2-cyclohexen-1-one
    (B1.12) mesosulfuron-methyl (PM, pp. 630-632), for example methyl 2-[[[[(4, 6-dimethoxy-2-pyrimidinyflamino]carbonyl]amino]sulphonyl]-4-[[(methylsulphonyl)amino]methyl]-benzoate
    (B1.13) iodosulfuron-methyl and its salts (PM, pp. 573-574), for example methyl 4-iodo-2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulphonyl]benzoate, monosodium salt
    (B1.14) sulfosulfuron (PM, pp. 913-915), for example N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]-carbonyl]-2-(ethylsulphonyl)imidazo[1,2-a]pyridine-3-sulphonamide
    (B1.15) flupyrsulfuron-methyl and its salts (PM pp. 470-473), for example methyl 2-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulphonyl]-6-(trifluoromethyl)-3-pyridinecarboxylate, monosodium salt
    (B1.16) fentrazamide (PM, pp. 427-428), for example 4-(2-chlorophenyl)-N-cyclohexyl-N-ethyl-4,5-dihydro-5-oxo-1H-tetrazole-1-carboxamide
    (B1.17) mefenacet (PM, pp. 621-622), for example 2-(2-benzothiazolyloxy)-N-methyl-N-phenyl-acetamide
    (B1.18) imazamethabenz-methyl (PM, pp. 551-552), for example methyl 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazole-2-yl]-4 (or 5)-methylbenzoate
    (B1.19) imazethapyr (PM, pp. 558-560), for example 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-ethyl-3-pyridinecarboxylic acid
    (B1.20) imazamox (PM, pp. 552-553), for example 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-(methoxymethyl)-3-pyridinecarboxylic acid
    (B1.21) flurtamone (PM, pp. 482-483), for example 5-(methylamino)-2-phenyl-4-[3-(trifluoro-methyl)phenyl]-3(2H)-furanone
    (B1.22) isoproturon (PM, pp. 584-585), for example N,N-dimethyl-N′-[4-(1-methylethyl)-phenyl]urea
    (B1.23) quinclorac (PM, pp. 869-870), for example 3,7-dichloro-8-quinolinecarboxylic acid and
    
        group (B-2) comprising herbicides which are predominantly active against graminaceous and dicotyledonous harmful plants, from the group of compounds consisting of (listed by “common name” and a reference, for example “The Pesticide Manual” 13th Ed., British Crop Protection Council 2003, abbreviated “PM”)
    
    
    (B2.1) 2,4-DB (PM, pp. 264-266) and its esters and salts, for example (2,4-dichlorophenoxy)-acetic acid
    (B2.2) dicamba (PM, pp. 278-280) and its esters and salts, for example 3,6-dichloro-2-methoxy-benzoic acid
    (B2.3) clomazone (PM, p. 191), for example 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone
    (B2.4) triclopyr (PM, pp. 1001-1002) and its salts and esters, for example [(3,5,6-trichloro-2-pyridinyl)oxy]acetic acid
    (B2.5) fluroxypyr and its salts and esters (PM, pp. 478-481), for example 1-methylheptyl-[(4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy]acetate
    (B2.6) thifensulfuron-methyl (PM, pp. 963-965), for example methyl 3-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yflamino]carbonyl]amino]sulphonyl]-2-thiophenecarboxylate
    (B2.7) amidosulfuron (PM, pp. 27-28), for example N-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]-carbonyl]amino]sulphonyl]-N-methyl-methanesulphonamide
    (B2.8) tribenuron-methyl (PM, pp. 996-998), for example methyl 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)methylamino]carbonyl]amino]sulphonyl]benzoate
    (B2.9) metsulfuron-methyl (PM pp. 677-678), for example methyl 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yflamino]carbonyl]amino]sulphonyl]benzoate
    (B2.10) picloram and its salts and esters (PM pp. 782-785), for example 4-amino-3,5,6-trichloro-2-pyridinecarboxylic acid
    (B2.11) carfentrazone-ethyl (PM pp. 143-144), for example ethyl α,2-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]-4-fluorobenzene-propanoate
    (B2.12) chlopyralid (PM, pp. 194-195), for example 3,6-dichloro-2-pyridinecarboxylic acid
    (B2.13) batafenacil (PM, pp. 120-121), for example 1,1-dimethyl-2-oxo-2-(2-propenyloxy)ethyl 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-benzoate
    (B2.14) isoxaben (PM, pp. 587-588), for example N-[3-(1-ethyl-1-methylpropyl)-5-isoxazolyl]-2,6-dimethoxybenzamide
    (B2.15) thiazopyr (PM, pp. 961-962), for example methyl 2-(difluoromethyl)-5-(4,5-dihydro-2-thiazolyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate
    (B2.16) flurtamone (PM, pp. 482-483), for example 5-(methylamino)-2-phenyl-4-[3-(trifluoromethyl)phenyl]-3(2H)-furanone
    (B2.17) aclonifen (PM, p. 13), for example 2-chloro-6-nitro-3-phenoxybenzenamine
    (B2.18) lactofen (PM, pp. 596-597), for example 2-ethoxy-1-methyl-2-oxoethyl 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate
    (B2.19) fomesafen (PM, pp. 492-493), for example 5-[2-chloro-4-(trifluoromethyl)phenoxy]-N-(methylsulphonyl)-2-nitrobenzamide
    (B2.20) chlorimuron-ethyl (PM, pp. 161-162), ethyl 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)-amino]carbonyl]amino]sulphonyl]benzoate
    (B2.21) mesotrione (PM, pp. 631-632), 2-[4-(methylsulphonyl)-2-nitrobenzoyl]-1,3-cyclohexane-dione
    (B2.22) sulcotrione (PM, pp. 908-909), for example 2-[2-chloro-4-(methylsulphonyl)benzoyl]-1,3-cyclohexanedione
    (B2.23)






    (B2.24)






    (B2.25) bromoxynil (PM, pp. 111-113) and its salts and esters, for example 3,5-dibromo-4-hydroxybenzonitrile
    (B2.26) ioxynil (PM, pp. 574-576) and its esters and salts, for example 4-hydroxy-3,5-diiodobenzonitrile
    (B2.27) diflufenican (PM, pp. 310-311), for example N-(2,4-difluorophenyl)-2-[3-(trifluoromethyl)phenoxy]-3-pyridinecarboxamide
    (B2.28) picolinafen (PM, pp. 785-786), for example N-(4-fluorophenyl)-6-[3-(trifluoro-methyl)phenoxy]-2-pyridinecarboxamide
    (B2.29) chloransulam (U.S. Pat. No. 5,163,995) and its esters and salts, for example methyl 3-chloro-2-[[(5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-sulphonamino]benzoate
    (B2.30) imazaquin (Los, M. et al., Abstr. Pap. 184th ACS Nat. Meet., Kansas City, Sep. 12-17th, 1982, Ref. Pest 21), for example 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-3-quinolinecarboxylic acid
    (B2.31) trifloxysulfuron and its salts (S. Howard et al., BCPC-Weeds, 2001, Brighton, Vol. 1, 29-34), for example N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-3-(2,2,2-trifluoroethoxy)-2-pyridinesulphonamide, monosodium salt and
    
        group (B-3) comprising herbicides which are predominantly active against dicotyledonous harmful plants, from the group of compounds consisting of (listed by “common name” and a reference, for example “The Pesticide Manual” 13th Ed., British Crop Protection Council 2003, abbreviated “PM”)
    
    
    (B3.1) foramsulfuron (PM, pp. 494-495), for example 2-[[[[(4,6-dimethoxy-2-pyrimi-dinyl)amino]carbonyl]amino]sulphonyl]-4-(formylamino)-N,N-dimethylbenz-amide
    (B3.2) iodosulfuron-methyl and its salts (PM, pp. 573-574), for example methyl 4-iodo-2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]-sulphonyl]benzoate, monosodium salt
    (B3.3) sulfosulfuron (PM, pp. 913-915), for example N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-2-(ethylsulphonyl)imidazo[1,2-a]pyridine-3-sulphonamide
    (B3.4) amicarbazone (PM, pp. 26-27), for example 4-amino-N-(1,1-dimethylethyl)-4,5-dihydro-3-(1-methylethyl)-5-oxo-1H-1,2,4-triazole-1-carboxamide
    (B3.5) propoxycarbazone-sodium (PM, pp. 831-832), for example methyl 2-[[[(4,5-dihydro-4-methyl-5-oxo-3-propoxy-1H-1,2,4-triazol-1-yl)carbonyl]amino]-sulphonyl]benzoate, sodium salt
    (B3.6) flucarbazone-sodium (PM, pp. 447-448), for example 4,5-dihydro-3-methoxy-4-methyl-5-oxo-N-[[2-(trifluoromethoxy)phenyl]sulphonyl]-1H-1,2,4-triazole-1-carboxamide, sodium salt
    (B3.7) flufenacet (PM, pp. 454-455), for example N-(4-fluorophenyl)-N-(1-methylethyl)-2-[[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]oxy]acetamide
    (B3.8) metribuzin (PM, pp. 675-676), for example 4-amino-6-(1,1-dimethylethyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one
    (B3.9) triasulfuron (PM, pp. 990-991), for example 2-(2-chloroethoxy)-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulphonamide
    (B3.10) naproanilide (PM, pp. 695-696), for example 2-(2-naphthalenyloxy)-N-phenyl-propanamide
    (B3.11) imazapyr (PM, pp. 555-556), for example 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-3-pyridinecarboxylic acid
    (B3.12) sulfosate (EP-A 54382), for example trimethylsulphonium N-phosphono-methylglycine
    (B3.13) simazine (PM, pp. 891-892), for example 6-chloro-N,N′-diethyl-1,3,5-triazine-2,4-diamine
    (B3.14) trifluralin (PM, pp. 1012-1014), for example 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)benzenamine
    (B3.15) pendimethalin (PM, pp. 752-753), for example N-(1-ethylpropyl)-3,4-dimethyl-2,6-dinitrobenzenamine
    (B3.16) oxadiargyl (PM, pp. 725-726), for example 3-[2,4-dichloro-5-(2-propynyloxy)-phenyl]-5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2(3H)-one
    (B.3.17) oryzalin (PM, pp. 723-724), for example 4-(dipropylamino)-3,5-dinitrobenzenesulphonamide
    (B3.18) flazasulfuron (PM, pp. 437-438), for example N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-3-(trifluoromethyl)-2-pyridinesulphonamide
    (B3.19) sulfometuron-methyl (PM, pp. 912-913), for example methyl 2-[[[[(4,6-dimethyl-2-pyrimidinyl)amino]carbonyl]amino]sulphonyl]benzoate
    (B3.20) metazachlor (PM, pp. 641-642), for example 2-chloro-N-(2,6-dimethylphenyl)-N-(1H-pyrazol-1-ylmethyl)acetamide
    (B3.21) metolachlor (PM, pp. 668-669), 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide
    (B3.22) S-metolachlor (PM, pp. 669-670), for example (S)-2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide
    (B3.23) alachlor (PM, pp. 17-19), for example 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide
    (B3.24) atrazine (PM, pp. 39-41), for example 6-chloro-N-ethyl-N′-(1-methylethyl)-1,3,5-triazine-2,4-diamine
    (B3.25) isoxaflutole (PM, pp. 589-590), for example (5-cyclopropyl-4-isoxazolyl)[2-(methylsulphonyl)-4-(trifluoromethyl)phenyl]methanone
    (B3.26) quinmerac (PM, pp. 870-871), for example 7-chloro-3-methyl-8-quinoline-carboxylic acid
    (B3.27) flumiclorac-pentyl (PM, pp. 460-461), for example pentyl[2-chloro-4-fluoro-5-(1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)phenoxy]acetate
    (B3.28) quinclorac (PM pp. 869-870), for example 3,7-dichloro-8-quinolinecarboxylic acid
    (B3.29)






    (B3.30)






    (B3.31)






    (B3.32)






    (B3.33)






    (B3.34)






    (B3.35)






    (B3.36)






    (B3.37) pyrithiobac and its esters and salts (BCPC-Weeds, Brighton, 1991, Vol. 1, 57), for example sodium 2-chloro-6-[(4,6-dimethoxy-2-pyrimidinyl)thio]benzoate and
    
        group (B-4) comprising predominantly non-selective herbicides from the group of compounds consisting of (listed by “common name” and a reference, for example “The Pesticide Manual” 13th Ed., British Crop Protection Council 2003, abbreviated “PM”)
    
    
    (B4.1) glyphosate, for example N-(phosphonomethyl)glycine, which is preferably used as glyphosate-isopropylammonium, glyphosate-sesquisodium, glyphosate-trimesium (PM, pp. 513-516)
    (B4.2) glufosinate, also comprising glufosinate-P, for example 4-[hydroxy(methyl)-phosphinoyl]-DL-homoalanine, 4-[hydroxy(methyl)phosphinoyl]-L-homoalanine, preferably used as glufosinate-ammonium and glufosinate-P-ammonium, respectively (PM, pp. 511-512)
    (B4.3) oxyfluorfen (PM, pp. 738-739), for example 2-chloro-1-(3-ethoxy-4-nitrophenoxy)-4-(trifluoromethyl)benzene
    (B4.4) diuron (PM, pp. 347-348), for example N′-(3,4-dichlorophenyl)-N,N-dimethylurea
    (B4.5) MSMA, for example monosodium methylarsonate
    (B4.6) bromacil (PM, pp. 106-107), for example 5-bromo-6-methyl-3-(1-methylpropyl)-2,4(1H,3H)-pyrimidinedione
    (B4.7) norflurazon (PM, pp. 711-712), 4-chloro-5-(methylamino)-2 [3-(trifluoromethyl)-phenyl]-3(2H)-pyridazinone
    (B4.8) azafenidin (DE-A 28 01 429), for example 2-[2,4-dichloro-5-(2-propynyloxy)phenyl]-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one
    (B4.9) tebuthiuron (PM, pp. 929-930), for example N-[5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]-N,N′-dimethylurea.


If, in the context of this description, the short form of the “common name” of an active compound is used, this comprises in each case all customary derivatives, such as the esters and salts, and isomers, in particular optical isomers, especially the commercially available form or forms. If the “common name” refers to an ester or a salt, this in each case also comprises all other customary derivatives, such as other esters and salts, the free acids and neutral compounds, and isomers, in particular optical isomers, especially the commercially available form or forms. The given chemical compound names refer to at least one of the compounds embraced by the “common name”, frequently to a preferred compound. In the case of sulphonamides such as sulphonylureas, salts also include salts formed by exchanging a hydrogen atom on the sulphonamide group for a cation.
When using the combinations according to the invention of insecticide/acaricide and herbicide, the herbicides of group (B1) are particularly suitable for controlling monocotyledonous harmful plants, the herbicides of group (B2) are particularly suitable for controlling weed grasses and dicotyledonous harmful plants, the herbicides of group (B3) are particularly suitable for controlling dicotyledonous harmful plants and the herbicides of group (B4) are particularly suitable for the non-selective control of harmful plants or of harmful plants in transgenic crops.
The combinations according to the invention of insecticide/acaricide and herbicide comprise an insecticidally/acaricidally effective amount of component (A) and a herbicidally effective amount of component (B) and may comprise further components, for example agrochemically active compounds of a different type and/or additives customary in crop protection and/or formulation auxiliaries, or may be used together with these compounds. Preference is given to combinations of insecticide/acaricide and herbicide comprising a synergistically effective amount of components (A) and (B).
In a preferred embodiment, the combinations according to the invention of insecticide/acaricide and herbicide have synergistic actions. The synergistic actions can be observed, for example, when the commercially available formulations of active compounds (A) and (B) are applied together.
The synergistic effects permit a reduction of the application rates of the insecticidal/acaricidal tetramic and derivatives, a higher efficacy at the same application rate and/or a reduction in the number of individual applications required and—as a result for the user—an economically and ecologically improved control of animal pests over the period of weed control.
For example, the combinations according to the invention of insecticidally/acaricidally active compounds of group (A) and herbicides (B) allow the activity to be synergistically enhanced in a manner which by far and unexpectedly exceeds the activities which can be achieved with the formulations of the individual active compounds (A) and (B).
The formulae mentioned in groups (A) and (B) include all stereoisomers and their mixtures, in particular also racemic mixtures, and—if enantiomers are possible—the respective biologically active enantiomers.
Compounds of group (A) are described, for example, in the laid-open publications mentioned at the outset.
The compounds of group (B) are known herbicides. The following group members are particularly preferred as mixing partners of the compounds of component (A):
From group (B1): diclofop-methyl (B1.2); fenoxaprop-P-ethyl (B1.5), haloxyfop-P (B1.6), quizalofop-P (B1.8), sethoxydim (B1.9), clethodim (B1.10), imazethapyr (B1.19), imazamox (B1.20).
From group (B2): clomazone (B2.3), lactofen (B2.18), fomesafen (B2.19), bromoxynil (B2.25), ioxynil (B2.26), diflufenican (B2.27), chloransulam (B2.29), imazaquin (B2.30), trifloxysulfuron (B2.31).
From group (B3): pyrithiobac (B3.37).
From group (B4): glyphosate (B4.1), glufosinate (B4.2).
Emphasis is given to glyphosate (B4.1). Emphasis is likewise given to glufosinate (B4.2).
The following combinations are particularly preferred: (A1+B4.1), (A1+B4.2), (A2+B4.1), (A2+B4.2).
Preferred are combinations of insecticide/acaricide and herbicide comprising one or more insecticides/acaricides (A) and one or more herbicides (B), preferably from group (B1) or (B2), (B3) or (B4). More preference is given to combinations of insecticides/acaricides (A) and one or more herbicides (B) according to the scheme: (A)+(B1)+(B2), (A)+(B1)+(B3), (A)+(B1)+(B4), (A)+(B2)+(B3), (A)+(B2)+(B4), (A)+(B3)+(B4).
Very particularly preferred mixtures are:

    Backdraft SL (glyphosate+imazaquin)
    Canopy EX (tribenzuron+chlorimuron)
    Canopy XL (sulfentrazone+chlorimuron)
    Extreme (glyphosate+imazapyr)
    Flexstar GT (glyphosate+fomesafen)
    Fusion (fluazifop+fenoxaprop)
    Prefix (fomesafen+S-metolachlor)
    Scepter O.T. (imazaquin+acifluorfen)
    Select Max (clethodim+glyphosate)
    Sequence (glyphosate+S-metolachlor)
    Squadron (imazaquin+pendimethalin)
    Storm 4S (bentazone+acifluorfen)
    Suprend (trifloxysulfuron+prometryn)


In addition, the active compound combinations (mixture) may comprise further fungicidally, acaricidally or insecticidally active additional components.
The application rate of the active compounds of groups (A) and (B) may vary within wide ranges, for example between 0.001 and 8 kg of AS/ha. Whenever the abbreviation AS/ha is used in the present description, this is to be understood as meaning “active substance per hectare”, based on 100% pure active compounds.
In the combinations according to the invention between compounds of groups (A) and (B1), the compounds of group (B1) are usually applied at an application rate of from 0.001 to 1.5 kg of AS/ha, preferably 0.005 to 1.2 kg of AS/ha. In the other combinations between compounds of groups (A) and (B), the compounds of group (B) are usually applied at an application rate of from 0.001 to 8 kg of AS/ha, preferably from 0.005 to 5 kg of AS/ha. In the combinations according to the invention, the compound of group (A) or the compounds of group (A) are preferably employed at an application rate of from 1 to 200 g of AS/ha.
The mixing ratio of the compounds of group (A) to those of group (B1) is advantageously from 1:1500 to 120:1, preferably from 1:400 to 18:1. The mixing ratio of the compounds of group (A) to those of group (B2), (B3) or (B4) is advantageously from 1:8000 to 800:1, preferably from 1:100 to 100:1.
When using the active compounds of group (B) in crop plants, it may be expedient, depending on the crop plant, to apply a safener above certain application rates to reduce or avoid possible damage to the crop plant. Such safeners are known to the person skilled in the art. Particularly suitable safeners are benoxacor, cloquintocet, cyprosulfamide, dichlormid, fenclorim, fenchlorazole, furilazole, isoxadifen, mefenpyr, 4-(dichloroacetyl)-1-oxa-4-azaspiro[4.5]decane (MON4660, CAS 71526-07-3), 2,2,5-trimethyl-3-(dichloroacetyl)-1,3-oxazolidine (R-29148, CAS 52836-31-4). Emphasis is given to cyprosulfamide, isoxadifen, mefenpyr.
The application rates are 1-1000 g of ai/ha, preferably 2-500 g of ai/ha.
If appropriate, the active compound combinations (mixtures) described may comprise a safener. This is also embraced by the invention.
The active compounds can generally be formulated as a water-soluble wettable powder (WP), as water-dispersible granules (WDG), as water-emulsifiable granules (WEG), as a suspoemulsion (SE) or as an oil suspension concentrate (SC).
Application of the combinations according to the invention of insecticide/acaricide and herbicide, if appropriate with the use of a safener, is preferably in annual crops such as, for example, vegetables, melons, ornamental plants, cereals, maize, soya beans, cotton, oilseed rape, potatoes, beet, sugar cane, sunflowers, coffee, tea.
The crops to be protected, which have only been described in a general manner, are described in a more differentiated and more specific manner below. Thus, with respect to the use, vegetable is to be understood as meaning, for example, fruit vegetables and flower-heads as vegetables, for example bell peppers, chilli peppers, tomatoes, aubergines, cucumbers, cucurbits, courgettes, broad beans, runner beans, bush beans, peas, artichokes; but also leafy vegetables, for example lettuce, chicory, endives, cress, rocket salad, field salad, iceberg lettuce, leek, spinach, Swiss chard;
furthermore tuber vegetables, root vegetables and stem vegetables, for example celeriac, beetroot, carrots, garden radish, horseradish, scorzonera, asparagus, table beet, palm shoots, bamboo shoots, moreover bulb vegetables, for example onions, leek, fennel, garlic;

furthermore brassica vegetables, such as cauliflowers, broccoli, kohlrabi, red cabbage, white cabbage, green cabbage, Savoy cabbage, Brussels sprouts, Chinese cabbage.

With respect to use, cereal crops are to be understood as meaning, for example, wheat, barley, rye, oats, triticale, but also millet and rice.
The present invention furthermore relates to a method for improving the utilization of the production potential of a transgenic plant, characterized in that the plant is treated with an effective amount of the active compound combinations according to the invention. It is already known that the production potential of a transgenic plant can be enhanced by treatment with the compound of the formula (I) (WO 2009/132779). This effect is increased by treatment with the active compound combinations according to the invention.
The active compound combinations (mixtures) according to the invention, if appropriate with use of a safener, are suitable for protecting plants and plant organs, for increasing harvest yields, improving the quality of the harvested material and for controlling animal pests, in particular insects, arachnids and nematodes, encountered in agriculture, and they are also tolerated well by plants, have favourable homeotherm toxicity and are tolerated well by the environment. They are preferably used as crop protection compositions. They are active against normally sensitive and resistant species and against all or individual development stages.
The abovementioned pests include in particular:
From the class of the Arachnida, for example, Acarus spp., Aceria sheldoni, Aculops spp., Aculus spp., Amblyomma spp., Amphitetranychus viennensis, Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa, Chorioptes spp., Dermanyssus gallinae, Eotetranychus spp., Epitrimerus pyri, Eutetranychus spp., Eriophyes spp., Halotydeus destructor, Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus mactans, Metatetranychus spp., Nuphersa spp., Oligonychus spp., Ornithodoros spp., Panonychus spp., Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, Stenotarsonemus spp., Tarsonemus spp., Tetranychus spp., Vasates lycopersici. 
From the order of the Heteroptera, for example, Anasa tristis, Antestiopsis spp., Blissus spp., Calocoris spp., Campylomma livida, Cavelerius spp., Cimex spp., Collaria spp., Creontiades dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus spp., Euschistus spp., Eurygaster spp., Heliopeltis spp., Horcias nobilellus, Leptocorisa spp., Leptoglossus phyllopus, Lygus spp., Macropes excavatus, Miridae, Monalonion atratum, Nezara spp., Oebalus spp., Pentomidae, Piesma quadrata, Piezodorus spp., Psallus spp., Pseudacysta persea, Rhodnius spp., Sahlbergella singularis, Scaptocoris castanea, Scotinophora spp., Stephanitis nashi, Tibraca spp., Triatoma spp.
From the order of the Homoptera, for example, Acyrthosipon spp., Acrogonia spp., Aeneolamia spp., Agonoscena spp., Aleurodes spp., Aleurolobus barodensis, Aleurothrixus spp., Amrasca spp., Anuraphis cardui, Aonidiella spp., Aphanostigma pin, Aphis spp., Arboridia apicalis, Aspidiella spp., Aspidiotus spp., Atanus spp., Aulacorthum solani, Bemisia spp., Brachycaudus helichrysii, Brachycolus spp., Brevicoryne brassicae, Calligypona marginata, Carneocephala fulgida, Ceratovacuna lanigera, Cercopidae, Ceroplastes spp., Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita onukii, Chromaphis juglandicola, Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli, Coccus spp., Cryptomyzus ribis, Dalbulus spp., Dialeurodes spp., Diaphorina spp., Diaspis spp., Drosicha spp., Dysaphis spp., Dysmicoccus spp., Empoasca spp., Eriosoma spp., Erythroneura spp., Euscelis bilobatus, Ferrisia spp., Geococcus coffeae, Hieroglyphus spp., Homalodisca coagulata, Hyalopterus arundinis, Icerya spp., Idiocerus spp., Idioscopus spp., Laodelphax striatellus, Lecanium spp., Lepidosaphes spp., Lipaphis erysimi, Macrosiphum spp., Mahanarva spp., Melanaphis sacchari, Metcalfiella spp., Meto-polophium dirhodum, Monellia costalis, Monelliopsis pecanis, Myzus spp., Nasonovia ribisnigri, Nephotettix spp., Nilaparvata lugens, Oncometopia spp., Orthezia praelonga, Parabemisia myricae, Paratrioza spp., Parlatoria spp., Pemphigus spp., Peregrinus maidis, Phenacoccus spp., Phloeomyzus passerinii, Phorodon humuli, Phylloxera spp., Pinnaspis aspidistrae, Planococcus spp., Protopulvinaria pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp., Psylla spp., Pteromalus spp., Pyrilla spp., Quadraspidiotus spp., Quesada gigas, Rastrococcus spp., Rhopalosiphum spp., Saissetia spp., Scaphoides titanus, Schizaphis graminum, Selenaspidus articulatus, Sogata spp., Sogatella furcifera, Sogatodes spp., Stictocephala festina, Tenalaphara malayensis, Tinocallis caryaefoliae, Tomaspis spp., Toxoptera spp., Trialeurodes spp., Trioza spp., Typhlocyba spp., Unaspis spp., Viteus vitifolii, Zygina spp.
From the order of the Thysanoptera, for example, Anaphothrips obscurus, Baliothrips biformis, Drepanothris reuteri, Enneothrips flavens, Frankliniella spp., Heliothrips spp., Hercinothrips femoralis, Rhipiphorothrips cruentatus, Scirtothrips spp., Taeniothrips cardamoni, Thrips spp.
The plant pest nematodes include, for example, Aphelenchoides spp., Bursaphelenchus spp., Ditylenchus spp., Globodera spp., Heterodera spp., sspp., Meloidogyne spp., Pratylenchus spp., Radopholus similis, Trichodorus spp., Tylenchulus semipenetrans, Xiphinema spp.
All plants and plant parts can be treated in accordance with the invention. Plants are understood here to mean all plants and plant populations, such as desired and undesired wild plants or crop plants (including naturally occurring crop plants). Crop plants can be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including the transgenic plants and including the plant varieties which can or cannot be protected by varietal property rights. Parts of plants are to be understood as meaning all above-ground and below-ground parts and organs of plants, such as shoot, leaf, flower and root, preferred examples which may be mentioned being leaves, needles, stems, trunks and flowers.
The treatment according to the invention of the plants and plant parts with the active compound combinations takes place directly or via action on their surroundings or habitat by customary treatment methods, for example by atomizing, spraying, nebulizing, dipping, evaporating, brushing-on and in the case of propagation material, in particular in the case of seeds, furthermore by coating with one or more layers, watering, soil mixing, furrow treatment, droplet application, in hydroponic systems, by planting hole treatment, soil, stem or flower injection, by dip application.
Preferred treatment with the active compound combinations is via foliar application.
As already mentioned above, it is possible to treat all plants and their parts in accordance with the invention. In a preferred embodiment, wild plant species and plant cultivars, or those obtained by conventional biological breeding, such as crossing or protoplast fusion, and parts thereof, are treated. In a further preferred embodiment, transgenic plants and plant cultivars obtained by genetic engineering, if appropriate in combination with conventional methods (Genetically Modified Organisms), and parts thereof are treated. The term “parts” or “parts of plants” or “plant parts” has been explained above.
More preferably, plants of the plant cultivars which are each commercially available or in use are treated in accordance with the invention. Plant cultivars are to be understood as meaning plants having new properties (“traits”) and which have been obtained by conventional breeding, by mutagenesis or by recombinant DNA techniques. They may be cultivars, biotypes and genotypes.
Depending on the plant species or plant cultivars, and the location and growth conditions (soils, climate, vegetation period, diet) thereof, the treatment according to the invention may also result in superadditive (“synergistic”) effects. For example, possibilities include reduced application rates and/or broadening of the activity spectrum and/or an increase in the activity of the compounds and compositions usable in accordance with the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to levels of water or soil salinity, increased flowering performance, easier harvesting, accelerated ripening, higher yields, higher quality and/or higher nutrient value of the harvested products, increased storage life and/or processibility of the harvested products, which exceed the effects actually to be expected.
The preferred transgenic plants or plant cultivars (those obtained by genetic engineering) which are to be treated in accordance with the invention include all plants which, through the genetic modification, received genetic material which imparts particular advantageous useful properties (“traits”) to these plants. Examples of such properties are better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to levels of water or soil salinity, enhanced flowering performance, easier harvesting, accelerated ripening, higher yields, higher quality and/or a higher nutritional value of the harvested products, better storage life and/or processability of the harvested products. Further and particularly emphasized examples of such properties are an improved defense of the plants against animal and microbial pests, such as against insects, mites, phytopathogenic fungi, bacteria and/or viruses, and also increased tolerance of the plants to certain herbicidally active compounds. Examples of transgenic plants which may be mentioned are the important crop plants, such as cereals (wheat, rice), maize, soya beans, potatoes, cotton, tobacco, oilseed rape and also fruit plants (with the fruits apples, pears, citrus fruits and grapes), and particular emphasis is given to maize, soya beans, potatoes, cotton, tobacco and oilseed rape. Traits that are emphasized in particular are increased defense of the plants against insects, arachnids, nematodes and slugs and snails by toxins formed in the plants, in particular those formed in the plants by the genetic material from Bacillus thuringiensis (for example by the genes CryIA(a), CryIA(b), CryIA(c), CryIIA, CryIIIA, CryIIIB2, Cry9c Cry2Ab, Cry3Bb and CryIF and also combinations thereof) (hereinbelow referred to as “Bt plants”). Traits that are also particularly emphasized are the improved defense of plants against fungi, bacteria and viruses by systemic acquired resistance (SAR), systemin, phytoalexins, elicitors and also resistance genes and correspondingly expressed proteins and toxins. Traits that are additionally particularly emphasized are the increased tolerance of the plants to certain active herbicidal compounds, for example imidazolinones, sulphonylureas, glyphosate or phosphinothricin (for example the “PAT” gene). The genes which impart the desired traits in question may also be present in combinations with one another in the transgenic plants. Examples of “Bt plants” include maize varieties, cotton varieties, soya varieties and potato varieties which are sold under the trade names YIELD GARD® (for example maize, cotton, soya), KnockOut® (for example maize), StarLink® (for example maize), Bollgard® (cotton), Nucotn® (cotton) and NewLeaf® (potato). Examples of herbicide-tolerant plants which may be mentioned are maize varieties, cotton varieties and soya bean varieties which are sold under the trade names Roundup Ready® (tolerance against glyphosate, for example maize, cotton, soya beans), Liberty Link® (tolerance against phosphinothricin, for example oilseed rape), IMI® (tolerance against imidazolinones) and STS (tolerance against sulphonylureas, for example maize). Herbicide-resistant plants (plants bred in a conventional manner for herbicide tolerance) which may be mentioned include the varieties sold under the name Clearfield® (for example maize). Of course, these statements also apply to plant cultivars which have these genetic traits or genetic traits which are still to be developed and will be developed and/or marketed in the future.
According to the invention all plants and plant parts can be treated. By plants is meant all plants and plant populations such as desirable and undesirable wild plants, cultivars and plant varieties (whether or not protectable by plant variety or plant breeder's rights). Cultivars and plant varieties can be plants obtained by conventional propagation and breeding methods which can be assisted or supplemented by one or more biotechnological methods such as by use of double haploids, protoplast fusion, random and directed mutagenesis, molecular or genetic markers or by bioengineering and genetic engineering methods. By plant parts is meant all above ground and below ground parts and organs of plants such as shoot, leaf, blossom and root, whereby for example leaves, needles, stems, branches, blossoms, fruiting bodies, fruits and seed as well as roots, corms and rhizomes are listed. Crops and vegetative and generative propagating material, for example cuttings, corms, rhizomes, runners and seeds also belong to plant parts.
Among the plants that can be protected by the method according to the invention, mention may be made of major field crops like corn, soya bean, cotton, Brassica oilseeds such as Brassica napus (e.g. canola), Brassica rapa, B. juncea (e.g. mustard) and Brassica carinata, rice, wheat, sugarbeet, sugarcane, oats, rye, barley, millet, triticale, flax, vine and various fruits and vegetables of various botanical taxa such as Rosaceae sp. (for instance pip fruit such as apples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, berry fruits such as strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and plantings), Rubiaceae sp. (for instance coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons, oranges and grapefruit); Solanaceae sp. (for instance tomatoes, potatoes, peppers, eggplant), Liliaceae sp., Compositiae sp. (for instance lettuce, artichoke and chicory—including root chicory, endive or common chicory), Umbelliferae sp. (for instance carrot, parsley, celery and celeriac), Cucurbitaceae sp. (for instance cucumber—including pickling cucumber, squash, watermelon, gourds and melons), Alliaceae sp. (for instance onions and leek), Cruciferae sp. (for instance white cabbage, red cabbage, broccoli, cauliflower, brussel sprouts, pak choi, kohlrabi, radish, horseradish, cress, Chinese cabbage), Leguminosae sp. (for instance peanuts, peas and beans—such as climbing beans and broad beans), Chenopodiaceae sp. (for instance mangold, spinach beet, spinach, beetroots), Malvaceae (for instance okra), Asparagaceae (for instance asparagus); horticultural and forest crops; ornamental plants; as well as genetically modified homologues of these crops.
The method of treatment according to the invention can be used in the treatment of genetically modified organisms (GMOs), e.g. plants or seeds. Genetically modified plants (or transgenic plants) are plants of which a heterologous gene has been stably integrated into the genome. The expression “heterologous gene” essentially means a gene which is provided or assembled outside the plant and when introduced in the nuclear, chloroplastic or mitochondrial genome gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing other gene(s) which are present in the plant (using, for example, antisense technology, cosuppression technology or RNA interference—RNAi—technology). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its particular location in the plant genome is called a transformation or transgenic event.
Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, diet), the treatment according to the invention may also result in superadditive (“synergistic”) effects. Thus, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the active compounds and compositions which can be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, bigger fruits, larger plant height, greener leaf colour, earlier flowering, higher quality and/or a higher nutritional value of the harvested products, higher sugar concentration within the fruits, better storage stability and/or processability of the harvested products are possible, which exceed the effects which were actually to be expected.
At certain application rates, the active compound combinations according to the invention may also have a strengthening effect in plants. Accordingly, they are also suitable for mobilizing the defense system of the plant against attack by unwanted microorganisms. This may, if appropriate, be one of the reasons of the enhanced activity of the combinations according to the invention, for example against fungi. Plant-strengthening (resistance-inducing) substances are to be understood as meaning, in the present context, those substances or combinations of substances which are capable of stimulating the defense system of plants in such a way that, when subsequently inoculated with unwanted microorganisms, the treated plants display a substantial degree of resistance to these microorganisms. In the present case, unwanted microorganisms are to be understood as meaning phytopathogenic fungi, bacteria and viruses. Thus, the substances according to the invention can be employed for protecting plants against attack by the abovementioned pathogens within a certain period of time after the treatment. The period of time within which protection is effected generally extends from 1 to 10 days, preferably 1 to 7 days, after the treatment of the plants with the active compounds.
Plants and plant cultivars which are preferably to be treated according to the invention include all plants which have genetic material which imparts particularly advantageous, useful traits to these plants (whether obtained by breeding and/or biotechnological means).
Plants and plant cultivars which are also preferably to be treated according to the invention are resistant against one or more biotic stresses, i.e. said plants show a better defense against animal and microbial pests, such as against nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and/or viroids.
Examples of nematode-resistant plants are described in e.g. U.S. patent application Ser. Nos. 11/765,491, 11/765,494, 10/926,819, 10/782,020, 12/032,479, 10/783,417, 10/782,096, 11/657,964, 12/192,904, 11/396,808, 12/166,253, 12/166,239, 12/166,124, 12/166,209, 11/762,886, 12/364,335, 11/763,947, 12/252,453, 12/209,354, 12/491,396 or 12/497,221.
Plants and plant cultivars which may also be treated according to the invention are those plants which are resistant to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, cold temperature exposure, heat exposure, osmotic stress, flooding, increased soil salinity, increased mineral exposure, ozone exposure, high light exposure, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients, shade avoidance.
Plants and plant cultivars which may also be treated according to the invention, are those plants characterized by enhanced yield characteristics. Increased yield in said plants can be the result of, for example, improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency and accelerated maturation. Yield can furthermore be affected by improved plant architecture (under stress and non-stress conditions), including but not limited to, early flowering, flowering control for hybrid seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition, such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction in anti-nutritional compounds, improved processability and better storage stability.
Examples of plants with the above-mentioned traits are non-exhaustively listed in Table A.
Plants that may be treated according to the invention are hybrid plants that already express the characteristic of heterosis or hybrid vigor which results in generally higher yield, vigor, health and resistance towards biotic and abiotic stresses. Such plants are typically made by crossing an inbred male-sterile parent line (the female parent) with another inbred male-fertile parent line (the male parent). Hybrid seed is typically harvested from the male sterile plants and sold to growers. Male sterile plants can sometimes (e.g. in corn) be produced by detasseling, i.e. the mechanical removal of the male reproductive organs (or males flowers) but, more typically, male sterility is the result of genetic determinants in the plant genome. In that case, and especially when seed is the desired product to be harvested from the hybrid plants it is typically useful to ensure that male fertility in the hybrid plants is fully restored. This can be accomplished by ensuring that the male parents have appropriate fertility restorer genes which are capable of restoring the male fertility in hybrid plants that contain the genetic determinants responsible for male-sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) were for instance described in Brassica species (WO 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 and U.S. Pat. No. 6,229,072). However, genetic determinants for male sterility can also be located in the nuclear genome. Male sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396 in which, for example, a ribonuclease such as barnase is selectively expressed in the tapetum cells in the stamens. Fertility can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as barstar (e.g. WO 91/02069).
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may be treated according to the invention are herbicide-tolerant plants, i.e. plants made tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation, or by selection of plants containing a mutation imparting such herbicide tolerance.
Herbicide-resistant plants are for example glyphosate-tolerant plants, i.e. plants made tolerant to the herbicide glyphosate or salts thereof. Plants can be made tolerant to glyphosate through different means. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., 1983, Science 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp. (Barry et al., 1992, Curr. Topics Plant Physiol. 7, 139-145), the genes encoding a petunia EPSPS (Shah et al., 1986, Science 233, 478-481), a tomato EPSPS (Gasser et al., 1988, J. Biol. Chem. 263, 4280-4289), or an eleusine EPSPS (WO 01/66704). It can also be a mutated EPSPS as described in for example EP 0837944, WO 00/66746, WO 00/66747 or WO02/26995. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxido-reductase enzyme as described in U.S. Pat. Nos. 5,776,760 and 5,463,175. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme as described in for example WO 02/036782, WO 03/092360, WO 05/012515 and WO 07/024782. Glyphosate-tolerant plants can also be obtained by selecting plants containing naturally-occurring mutations of the above-mentioned genes, as described in for example WO 01/024615 or WO 03/013226. Plants expressing EPSPS genes that confer glyphosate tolerance are described in e.g. U.S. patent application Ser. Nos. 11/517,991, 10/739,610, 12/139,408, 12/352,532, 11/312,866, 11/315,678, 12/421,292, 11/400,598, 11/651,752, 11/681,285, 11/605,824, 12/468,205, 11/760,570, 11/762,526, 11/769,327, 11/769,255, 11/943801 or 12/362,774. Plants comprising other genes that confer glyphosate tolerance, such as decarboxylase genes, are described in e.g. U.S. patent application Ser. Nos. 11/588,811, 11/185,342, 12/364,724, 11/185,560 or 12/423,926.
Other herbicide-resistant plants are for example plants that are made tolerant to herbicides inhibiting the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant to inhibition, e.g. described in U.S. patent application Ser. No. 11/760,602. One such efficient detoxifying enzyme is an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are for example described in U.S. Pat. Nos. 5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082; 5,908,810 and 7,112,665.
Further herbicide-tolerant plants are also plants that are made tolerant to the herbicides inhibiting the enzyme hydroxyphenylpyruvatedioxygenase (HPPD). HPPD is an enzyme that catalyses the reaction in which para-hydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants tolerant to HPPD-inhibitors can be transformed with a gene encoding a naturally-occurring resistant HPPD enzyme, or a gene encoding a mutated or chimeric HPPD enzyme as described in WO 96/38567, WO 99/24585 and WO 99/24586. Tolerance to HPPD-inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the formation of homogentisate despite the inhibition of the native HPPD enzyme by the HPPD-inhibitor. Such plants and genes are described in WO 99/34008 and WO 02/36787. Tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding an enzyme having prephenate dehydrogenase (PDH) activity in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO 2004/024928. Further, plants can be made more tolerant to HPPD-inhibitor herbicides by adding into their genome a gene encoding an enzyme capable of metabolizing or degrading HPPD inhibitors, such as the CYP450 enzymes shown in WO 2007/103567 and WO 2008/150473.
Still further herbicide-resistant plants are plants that are made tolerant to acetolactate synthase (ALS) inhibitors. Known ALS-inhibitors include, for example, sulphonylurea, imidazolinone, triazolopyrimidines, pyrimidinyloxy(thio)benzoates, and/or sulphonylaminocarbonyltriazolinone herbicides. Different mutations in the ALS enzyme (also known as acetohydroxyacid synthase, AHAS) are known to confer tolerance to different herbicides and groups of herbicides, as described for example in Tranel and Wright (2002, Weed Science 50:700-712), but also, in U.S. Pat. Nos. 5,605,011, 5,378,824, 5,141,870, and 5,013,659. The production of sulphonylurea-tolerant plants and imidazolinone-tolerant plants is described in U.S. Pat. Nos. 5,605,011; 5,013,659; 5,141,870; 5,767,361; 5,731,180; 5,304,732; 4,761,373; 5,331,107; 5,928,937; and 5,378,824; and international publication WO 96/33270. Other imidazolinone-tolerant plants are also described in for example WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006/024351, and WO 2006/060634. Further sulphonylurea- and imidazolinone-tolerant plants are also described in for example WO 07/024782 and U.S. Patent Application No. 61/288,958.
Other plants tolerant to imidazolinone and/or sulphonylurea can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or mutation breeding as described for example for soya beans in U.S. Pat. No. 5,084,082, for rice in WO 97/41218, for sugar beet in U.S. Pat. No. 5,773,702 and WO 99/057965, for lettuce in U.S. Pat. No. 5,198,599, or for sunflower in WO 01/065922.
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are insect-resistant transgenic plants, i.e. plants made resistant to attack by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such insect resistance.
An “insect-resistant transgenic plant”, as used herein, includes any plant containing at least one transgene comprising a coding sequence encoding:

    1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such as the insecticidal crystal proteins listed by Crickmore et al. (1998, Microbiology and Molecular Biology Reviews, 62: 807-813), updated by Crickmore et al. (2005) at the Bacillus thuringiensis toxin nomenclature, online at: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal portions thereof, e.g., proteins of the Cry protein classes Cry1Ab, Cry1Ac, Cry1B, Cry1C, Cry1D, Cry1F, Cry2Ab, Cry3Aa, or Cry3Bb or insecticidal portions thereof (e.g. EP-A 1999141 and WO 2007/107302), or such proteins encoded by synthetic genes as e.g. described in U.S. patent application Ser. No. 12/249,016; or
    2) a crystal protein from Bacillus thuringiensis or a portion thereof which is insecticidal in the presence of a second other crystal protein from Bacillus thuringiensis or a portion thereof, such as the binary toxin made up of the Cry34 and Cry35 crystal proteins (Moellenbeck et al. 2001, Nat. Biotechnol. 19: 668-72; Schnepf et al. 2006, Applied Environm. Microbiol. 71, 1765-1774) or the binary toxin made up of the Cry1A or Cry1F proteins and the Cry2Aa or Cry2Ab or Cry2Ae proteins (U.S. patent application Ser. No. 12/214,022 and EP 08010791.5); or
    3) a hybrid insecticidal protein comprising parts of two different insecticidal crystal proteins from Bacillus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, e.g., the Cry1A.105 protein produced by corn event MON89034 (WO 2007/027777); or
    4) a protein of any one of 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes induced in the encoding DNA during cloning or transformation, such as the Cry3Bb1 protein in corn events MON863 or MON88017, or the Cry3A protein in corn event MIR604; or
    5) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus, or an insecticidal portion thereof, such as the vegetative insecticidal (VIP) proteins listed at: http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html, e.g., proteins from the VIP3Aa protein class; or
    6) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin made up of the VIP1A and VIP2A proteins (WO 94/21795); or
    7) a hybrid insecticidal protein comprising parts from different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins in 1) above or a hybrid of the proteins in 2) above; or
    8) a protein of any one of 5) to 7) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein), such as the VIP3Aa protein in cotton event COT102; or
    9) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a crystal protein from Bacillus thuringiensis, such as the binary toxin made up of VIP3 and Cry1A or Cry1F (U.S. Patent Appl. No. 61/126,083 and 61/195,019), or the binary toxin made up of the VIP3 protein and the Cry2Aa or Cry2Ab or Cry2Ae proteins (U.S. patent application Ser. No. 12/214,022 and EP 08010791.5); or
    10) a protein of 9) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein).


Of course, an insect-resistant transgenic plant, as used herein, also includes any plant comprising a combination of genes encoding the proteins of any one of the above classes 1 to 10. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 10, to expand the range of target insect species affected when using different proteins directed at different target insect species, or to delay insect resistance development to the plants by using different proteins insecticidal to the same target insect species but having a different mode of action, such as binding to different receptor binding sites in the insect.
An “insect-resistant transgenic plant”, as used herein, further includes any plant containing at least one transgene comprising a sequence producing upon expression a double-stranded RNA which upon ingestion by a plant insect pest inhibits the growth of this insect pest, as described e.g. in WO 2007/080126, WO 2006/129204, WO 2007/074405, WO 2007/080127 and WO 2007/035650.
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are tolerant to abiotic stresses. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly useful stress tolerance plants include:

    1) plants which contain a transgene capable of reducing the expression and/or the activity of the poly(ADP-ribose) polymerase (PARP) gene in the plant cells or plants as described in WO 00/04173, WO/2006/045633, EP 04077984.5, or EP 06009836.5.
    2) plants which contain a stress tolerance enhancing transgene capable of reducing the expression and/or the activity of the PARG encoding genes of the plants or plants cells, as described e.g. in WO 2004/090140.
    3) plants which contain a stress tolerance enhancing transgene coding for a plant-functional enzyme of the nicotinamide adenine dinucleotide salvage synthesis pathway including nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyl transferase, nicotinamide adenine dinucleotide synthetase or nicotine amide phosphoribosyltransferase as described e.g. in EP 04077624.7, WO 2006/133827, PCT/EP07/002433, EP 1999263, or WO 2007/107326.


Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention show altered quantity, quality and/or storage-stability of the harvested product and/or altered properties of specific ingredients of the harvested product such as:

    1) transgenic plants which synthesize a modified starch, which in its physical-chemical characteristics, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the average chain length, the side chain distribution, the viscosity behaviour, the gelling strength, the starch grain size and/or the starch grain morphology, is changed in comparison with the synthesized starch in wild type plant cells or plants, so that this is better suited for special applications. Said transgenic plants synthesizing a modified starch are disclosed, for example, in EP 0571427, WO 95/04826, EP 0719338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188, WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO99/58688, WO 99/58690, WO 99/58654, WO 00/08184, WO 00/08185, WO 00/08175, WO 00/28052, WO 00/77229, WO 01/12782, WO 01/12826, WO 02/101059, WO 03/071860, WO 2004/056999, WO 2005/030942, WO 2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 2007/009823, WO 00/22140, WO 2006/063862, WO 2006/072603, WO 02/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1, EP 07090009.7, WO 01/14569, WO 02/79410, WO 03/33540, WO 2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66050, WO 99/53072, U.S. Pat. No. 6,734,341, WO 00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO 01/98509, WO 2005/002359, U.S. Pat. Nos. 5,824,790, 6,013,861, WO 94/04693, WO 94/09144, WO 94/11520, WO 95/35026 and WO 97/20936.
    2) transgenic plants which synthesize non-starch carbohydrate polymers or which synthesize non-starch carbohydrate polymers with altered properties in comparison to wild type plants without genetic modification. Examples are plants producing polyfructose, especially of the inulin and levan-type, as disclosed in EP 0663956, WO 96/01904, WO 96/21023, WO 98/39460, and WO 99/24593, plants producing alpha-1,4-glucans as disclosed in WO 95/31553, US 2002031826, U.S. Pat. Nos. 6,284,479, 5,712,107, WO 97/47806, WO 97/47807, WO 97/47808 and WO 00/14249, plants producing alpha-1,6 branched alpha-1,4-glucans, as disclosed in WO 00/73422, and plants producing alternan, as disclosed in WO 00/47727, WO 00/73422, EP 06077301.7, U.S. Pat. No. 5,908,975 and EP 0728213.
    3) transgenic plants which produce hyaluronan, as for example disclosed in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP 2006304779, and WO 2005/012529.
    4) transgenic plants or hybrid plants, such as onions with characteristics such as ‘high soluble solids content’, ‘low pungency’ (LP) and/or ‘long storage’ (LS), as described in U.S. patent application Ser. No. 12/020,360 and 61/054,026.


Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as cotton plants, with altered fiber characteristics. Such plants can be obtained by genetic transformation, or by selection of plants which contain a mutation imparting such altered fiber characteristics and include:

    a) Plants, such as cotton plants, containing an altered form of cellulose synthase genes as described in WO 98/00549
    b) Plants, such as cotton plants, containing an altered form of rsw2 or rsw3 homologous nucleic acids as described in WO 2004/053219
    c) Plants, such as cotton plants, with increased expression of sucrose phosphate synthase as described in WO 01/17333
    d) Plants, such as cotton plants, with increased expression of sucrose synthase as described in WO 02/45485
    e) Plants, such as cotton plants, wherein the timing of the plasmodesmatal gating at the basis of the fiber cell is altered, e.g. through downregulation of fiber-selective β-1,3-glucanase as described in WO 2005/017157, or as described in EP 08075514.3 or U.S. Patent Appl. No. 61/128,938
    f) Plants, such as cotton plants, having fibers with altered reactivity, e.g. through the expression of N-acetylglucosaminetransferase gene including nodC and chitin synthase genes as described in WO 2006/136351


Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered oil profile characteristics. Such plants can be obtained by genetic transformation, or by selection of plants which contain a mutation imparting such altered oil profile characteristics and include:

    a) Plants, such as oilseed rape plants, producing oil having a high oleic acid content as described e.g. in U.S. Pat. Nos. 5,969,169 , 5,840,946 or 6,323,392 or 6,063,947.
    b) Plants such as oilseed rape plants, producing oil having a low linolenic acid content as described in U.S. Pat. Nos. 6,270,828, 6,169,190, or 5,965,755.
    c) Plant such as oilseed rape plants, producing oil having a low level of saturated fatty acids as described e.g. in U.S. Pat. No. 5,434,283 or U.S. patent application Ser. No. 12/668,303.


Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered seed shattering characteristics. Such plants can be obtained by genetic transformation, or by selection of plants which contain a mutation imparting such altered seed shattering characteristics and include plants such as oilseed rape plants with delayed or reduced seed shattering as described in U.S. Patent Appl. No. 61/135,230, WO09/068313 and WO10/006732.
Particularly useful transgenic plants which may be treated according to the invention are plants containing transformation events, or combination of transformation events, that are the subject of petitions for non-regulated status, in the United States of America, to the Animal and Plant Health Inspection Service (APHIS) of the United States Department of Agriculture (USDA) whether such petitions are granted or are still pending. At any time this information is readily available from APHIS (4700 River Road, Riverdale, Md. 20737, USA), for instance on its internet site (URL http://www.aphis.usda.gov/brs/not_reg.html). On the filing date of this application the petitions for nonregulated status that were pending with APHIS or granted by APHIS were those listed in table B which contains the following information:

    
    
        Petition: the identification number of the petition. Technical descriptions of the transformation events can be found in the individual petition documents which are obtainable from APHIS, for example on the APHIS website, by reference to this petition number. These descriptions are herein incorporated by reference.
        Extension of Petition: reference to a previous petition for which an extension is requested.
        Institution: the name of the entity submitting the petition.
        Regulated article: the plant species concerned.
        Transgenic phenotype: the trait conferred to the plants by the transformation event.
        Transformation event or line: the name of the event or events (sometimes also designated as lines or lines) for which nonregulated status is requested.
        APHIS documents: various documents published by APHIS in relation to the Petition and which can be requested from APHIS.
    
    


Additional particularly useful plants containing single transformation events or combinations of transformation events are listed for example in the databases from various national or regional regulatory agencies (see for example http://gmoinfo.jrc.it/gmp_browse.aspx and http://cera-gmc.org/index.php?evidcode=&hstIDXCode=&gType=&AbbrCode=&atCode=&stCode=&coIDCode=&action=gm_crop_database&mode=Submit).
Further particularly transgenic plants include plants containing a transgene in an agronomically neutral or beneficial position as described in any of the patent publications listed in Table C.
In a particularly preferred variant, the process according to the invention is used to treat transgenic vegetable, cotton and soya bean species.







TABLE A







Non-exhaustive list of transgenic plants and events for working the invention. Source:


AgBios database (AGBIOS, P.O. Box 475, 106 St. John St. Merrickville, Ontario K0G1N0,


CANADA) which can be accessed under: http://www.agbios.com/dbase.php.











No.
Transgenic event
Company
Description
Crop





A-1
ASR368
Scotts Seeds
Glyphosate tolerance derived by inserting a modified 
Agrostis stolonifera





5-enolpyruvylshikimate-3-phosphate synthase (EPSPS)
Creeping bentgrass





encoding gene from Agrobacterium tumefaciens,






parent line B99061



A-2
Asr-368

Glyphosate tolerance; US 2006-162007
bentgrass


A-3
H7-1
Monsanto
Glyphosate herbicide tolerant sugar beet produced by inserting a
Beta vulgaris




Company
gene encoding the enzyme 5-enolypyruvylshikimate-3-






phosphate synthase (EPSPS) from the CP4 strain of






Agrobacterium tumefaciens,; WO 2004-074492



A-4
T120-7
Bayer
Introduction of the PPT-acetyltransferase (PAT) encoding gene
Beta vulgaris




CropScience
from Streptomyces viridochromogenes, an aerobic soil bacteria.





(Aventis
PPT normally acts to inhibit glutamine synthetase,





CropScience
causing a fatal accumulation of ammonia.





(AgrEvo))
Acetylated PPT is inactive.



A-5
GTSB77
Novartis Seeds;
Glyphosate herbicide tolerant sugar beet produced
Beta vulgaris (sugar




Monsanto
by inserting a gene encoding the enzyme 5-
beet)




Company
enolypyruvylshikimate-3-phosphate synthase






(EPSPS) from the CP4 strain of Agrobacterium tumefaciens.



A-6
T227-1

Glyphosate tolerance; US 2004-117870
Beta vulgaris sugar






beet


A-7
23-18-17, 23-198
Monsanto
High laurate (12:0) and myristate (14:0) canola
Brassica




Company
produced by inserting a thioesterase encoding gene
napus (Argentine




(formerly
from the California bay laurel (Umbellularia
Canola)




Calgene)
californica).



A-8
45A37, 46A40
Pioneer Hi-
High oleic acid and low linolenic acid canola
Brassica




Bred
produced through a combination of chemical
napus (Argentine




International
mutagenesis to select for a fatty acid desaturase
Canola)




Inc.
mutant with elevated oleic acid, and traditional






back-crossing to introduce the low linolenic acid trait.



A-9
46A12, 46A16
Pioneer Hi-
Combination of chemical mutagenesis, to achieve
Brassica




Bred
the high oleic acid trait, and traditional breeding
napus (Argentine




International
with registered canola varieties.
Canola)




Inc.




A-10
GT200
Monsanto
Glyphosate herbicide tolerant canola produced by
Brassica




Company
inserting genes encoding the enzymes 5-
napus (Argentine





enolypyruvylshikimate-3-phosphate synthase
Canola)





(EPSPS) from the CP4 strain of Agrobacterium tumefaciens 






and glyphosate oxidase from Ochrobactrum anthropi.



A-11
GT73, RT73
Monsanto
Glyphosate herbicide tolerant canola produced by
Brassica




Company
inserting genes encoding the enzymes 5-
napus (Argentine





enolypyruvylshikimate-3-phosphate synthase
Canola)





(EPSPS) from the CP4 strain of Agrobacterium tumefaciens 






and glyphosate oxidase from Ochrobactrum anthropi.



A-12
HCN10
Aventis
Introduction of the PPT-acetyltransferase (PAT)
Brassica




CropScience
encoding gene from Streptomyces
napus (Argentine





viridochromogenes, an aerobic soil bacteria. PPT
Canola)





normally acts to inhibit glutamine synthetase,






causing a fatal accumulation of ammonia.






Acetylated PPT is inactive.



A-13
HCN92
Bayer
Introduction of the PPT-acetyltransferase (PAT)
Brassica




CropScience
encoding gene from Streptomyces
napus (Argentine




(Aventis
viridochromogenes, an aerobic soil bacteria. PPT
Canola)




CropScience
normally acts to inhibit glutamine synthetase,





(AgrEvo))
causing a fatal accumulation of ammonia.






Acetylated PPT is inactive.



A-14
MS1, RF1
Aventis
Male-sterility, fertility restoration, pollination
Brassica



=>PGS1
CropScience
control system displaying glufosinate herbicide
napus (Argentine




(formerly Plant
tolerance. MS lines contained the barnase gene from
Canola)




Genetic
Bacillus amyloliquefaciens, RF lines contained the





Systems)
barstar gene from the same bacteria, and both lines






contained the phosphinothricin N-acetyltransferase






(PAT) encoding gene from Streptomyces hygroscopicus.



A-15
MS1, RF2
Aventis
Male-sterility, fertility restoration, pollination
Brassica



=>PGS2
CropScience
control system displaying glufosinate herbicide
napus (Argentine




(formerly Plant
tolerance. MS lines contained the barnase gene from
Canola)




Genetic
Bacillus amyloliquefaciens, RF lines contained the





Systems)
barstar gene from the same bacteria, and both lines






contained the phosphinothricin N-acetyltransferase






(PAT) encoding gene from Streptomyces hygroscopicus.



A-16
MS81×RF3
Bayer
Male-sterility, fertility restoration, pollination
Brassica




CropScience
control system displaying glufosinate herbicide
napus (Argentine




(Aventis
tolerance. MS lines contained the barnase gene from
Canola)




CropScience
Bacillus amyloliquefaciens, RF lines contained the





(AgrEvo))
barstar gene from the same bacteria, and both lines






contained the phosphinothricin N-acetyltransferase






(PAT) encoding gene from Streptomyces hygroscopicus.



A-17
MS-B2

Male sterility; WO 01/31042
Brassica napus






(Argentine Canola)


A-18
MS-BN1/RF-

Male sterility/restoration; WO 01/41558
Brassica napus



BN1


(Argentine Canola)


A-19
NS738, NS1471,
Pioneer Hi-
Selection of somaclonal variants with altered
Brassica napus



NS1473
Bred
acetolactate synthase (ALS) enzymes, following
(Argentine Canola)




International
chemical mutagenesis. Two lines (P1, P2) were





Inc.
initially selected with modifications at different






unlinked loci. NS738 contains the P2 mutation only.



A-20
OXY-235
Aventis
Tolerance to the herbicides bromoxynil and ioxynil
Brassica napus




CropScience
by incorporation of the nitrilase gene from
(Argentine Canola)




(formerly
Klebsiella pneumoniae.





Rhone Poulenc






Inc.)




A-21
PHY14, PHY35
Aventis
Male sterility was via insertion of the barnase
Brassica napus




CropScience
ribonuclease gene from Bacillus amyloliquefaciens;
(Argentine Canola)




(formerly Plant
fertility restoration by insertion of the barstar RNase





Genetic
inhibitor; PPT resistance was via PPT-





Systems)
acetyltransferase (PAT) from Streptomyces hygroscopicus.



A-22
PHY36
Aventis
Male sterility was via insertion of the barnase
Brassica napus




CropScience
ribonuclease gene from Bacillus amyloliquefaciens;
(Argentine Canola)




(formerly Plant
fertility restoration by insertion of the barstar RNase





Genetic
inhibitor; PPT-acetyltransferase (PAT) from





Systems)
Streptomyces hygroscopicus.



A-23
RT73

Glyphosate resistance; WO 02/36831
Brassica napus






(Argentine Canola)


A-24
T45 (HCN28)
Bayer
Introduction of the PPT-acetyltransferase (PAT)
Brassica napus




CropScience
encoding gene from Streptomyces
(Argentine Canola)




(Aventis
viridochromogenes, an aerobic soil bacteria. PPT





CropScience
normally acts to inhibit glutamine synthetase,





(AgrEvo))
causing a fatal accumulation of ammonia.






Acetylated PPT is inactive.



A-25
HCR-1
Bayer
Introduction of the glufosinate ammonium herbicide
Brassica rapa (Polish




CropScience
tolerance trait from transgenic B. napus line T45.
Canola)




(Aventis
This trait is mediated by the phosphinothricin





CropScience
acetyltransferase (PAT) encoding gene from S. viridochromogenes.





(AgrEvo))




A-26
ZSR500/502
Monsanto
Introduction of a modified 5-enol-pyruvylshikimate-
Brassica rapa (Polish




Company
3-phosphate synthase (EPSPS) and a gene from
Canola)





Achromobacter sp. that degrades glyphosate by






conversion to aminomethylphosphonic acid






(AMPA) and glyoxylate by interspecific crossing with GT73.



A-27
EE-1

Insect resistance (Cry1Ac); WO 2007/091277
aubergine


A-28
55-1/63-1
Cornell
Papaya ringspot virus (PRSV) resistant papaya
Carica




University
produced by inserting the coat protein (CP)
papaya (papaya)





encoding sequences from this plant potyvirus.



A-29
RM3-3, RM3-4,
Bejo Zaden BV
Male sterility was obtained via insertion of the
Cichorium



RM3-6

barnase ribonuclease gene from Bacillus
intybus (chicory)





amyloliquefaciens; PPT resistance was via the bar






gene from S. hygroscopicus, which encodes the PAT enzyme.



A-30
A, B
Agritope Inc.
Reduced accumulation of S-adenosylmethionine
Cucumis





(SAM), and consequently reduced ethylene
melo (melon)





synthesis, by introduction of the gene encoding S-






adenosylmethionine hydrolase.



A-31
CZW-3
Asgrow
Cucumber mosiac virus (CMV), zucchini yellows
Cucurbita




(USA);
mosaic (ZYMV) and watermelon mosaic virus
pepo (squash)




Seminis
(WMV) 2 resistant squash (Curcurbita pepo)





Vegetable Inc.
produced by inserting the coat protein (CP)





(Canada)
encoding sequences from each of these plant viruses






into the host genome.



A-32
ZW20
Upjohn (USA);
Zucchini yellows mosaic (ZYMV) and watermelon
Cucurbita




Seminis
mosaic virus (WMV) 2 resistant squash (Curcurbita
pepo (squash)




Vegetable Inc.
pepo) produced by inserting the coat protein (CP)





(Canada)
encoding sequences from each of these plant






potyviruses into the host genome.



A-33
66
Florigene Pty
Delayed senescence and sulphonylurea herbicide
Dianthus




Ltd.
tolerant carnations produced by inserting a truncated
caryophyllus





copy of the carnation aminocyclopropane cyclase
(carnation)





(ACC) synthase encoding gene in order to suppress






expression of the endogenous unmodified gene,






which is required for normal ethylene biosynthesis.






Tolerance to sulphonylurea herbicides was via the






introduction of a chlorsulfuron tolerant version of






the acetolactate synthase (ALS) encoding gene from tobacco.



A-34
4, 11, 15, 16
Florigene Pty
Modified colour and sulphonylurea herbicide
Dianthus




Ltd.
tolerant carnations produced by inserting two
caryophyllus





anthocyanin biosynthetic genes whose expression
(carnation)





results in a violet/mauve colouration. Tolerance to






sulphonylurea herbicides was obtained via the






introduction of a chlorsulfuron tolerant version of






the acetolactate synthase (ALS) encoding gene from tobacco.



A-35
959A, 988A,
Florigene Pty
Introduction of two anthocyanin biosynthetic genes
Dianthus



1226A, 1351A,
Ltd.
to result in a violet/mauve colouration; Introduction
caryophyllus



1363A, 1400A

of a variant form of acetolactate synthase (ALS).
(carnation)


A-36
3560.4.3.5

Glyphosate/ALS inhibitor-tolerance; WO
Glycine max L. (soya





2008002872
bean)


A-37
A2704-12

Glufosinate tolerance; WO 2006/108674
Glycine max L. (Soya






bean)


A-38
A2704-12,
Aventis
Glufosinate ammonium herbicide tolerant soya bean
Glycine max L. (soya



A2704-21,
CropScience
produced by inserting a modified phosphinothricin
bean)



A5547-35

acetyltransferase (PAT) encoding gene from the soil






bacterium Streptomyces viridochromogenes.



A-39
A5547-127
Bayer
Glufosinate ammonium herbicide tolerant soya bean
Glycine max L. (soya




CropScience
produced by inserting a modified phosphinothricin
bean)




(Aventis
acetyltransferase (PAT) encoding gene from the soil





CropScience
bacterium Streptomyces viridochromogenes.





(AgrEvo))




A-40
A5547-35

Glufosinate tolerance; WO 2006/108675
Glycine max L. (soya






bean)


A-41
DP-305423-1

High oleic acid/ALS inhibitor tolerance; WO
Glycine max L. (soya





2008/054747
bean)


A-42
DP356043
Pioneer Hi-
Soya bean event with two herbicide tolerance genes:
Glycine max L. (soya




Bred
glyphosate N-acetlytransferase, which detoxifies
bean)




International
glyphosate, and a modified acetolactate synthase (A





Inc.




A-43
G94-1, G94-19,
DuPont Canada
High oleic acid soya bean produced by inserting a
Glycine max L. (soya



G168
Agricultural
second copy of the fatty acid desaturase (GmFad2-1)
bean)




Products
encoding gene from soya bean, which resulted in






“silencing” of the endogenous host gene.



A-44
GTS 40-3-2
Monsanto
Glyphosate tolerant soya bean variety produced by
Glycine max L. (soya




Company
inserting a modified 5-enolpyruvylshikimate-3-
bean)





phosphate synthase (EPSPS) encoding gene from the






soil bacterium Agrobacterium tumefaciens.



A-45
GU262
Bayer
Glufosinate ammonium herbicide tolerant soya bean
Glycine max L. (soya




CropScience
produced by inserting a modified phosphinothricin
bean)




(Aventis
acetyltransferase (PAT) encoding gene from the soil





CropScience
bacterium Streptomyces viridochromogenes.





(AgrEvo))




A-46
MON87701

insect resistance (CryIac); WO 2009064652
Glycine max L. (soya






bean)


A-47
MON87705

altered fatty acid levels (mid-oleic and low saturate);
Glycine max L. (soya





WO 2010037016
bean)


A-48
MON87754

increased oil content; WO 2010024976
Glycine max L. (soya






bean)


A-49
MON87769

stearidonic acid (SDA) comprising oil; WO
Glycine max L. (soya





2009102873
bean)


A-50
MON89788
Monsanto
Glyphosate-tolerant soya bean produced by inserting
Glycine max L. (soya




Company
a modified 5-enolpyruvylshikimate-3-phosphate
bean)





synthase (EPSPS) encoding aroA (epsps) gene from






Agrobacterium tumefaciens CP4; WO2006130436



A-51
OT96-15
Agriculture &
Low linolenic acid soya bean produced through
Glycine max L. (soya




Agri-Food
traditional cross-breeding to incorporate the novel
bean)




Canada
trait from a naturally occurring fanl gene mutant






that was selected for low linolenic acid.



A-52
W62, W98
Bayer
Glufosinate ammonium herbicide tolerant soya bean
Glycine max L. (soya




CropScience
produced by inserting a modified phosphinothricin
bean)




(Aventis
acetyltransferase (PAT) encoding gene from the soil





CropScience
bacterium Streptomyces hygroscopicus.





(AgrEvo))




A-53
15985
Monsanto
Insect resistant cotton derived by transformation of
Gossypium hirsutum




Company
the DP50B parent variety, which contained event
L. (cotton)





531 (expressing Cry1Ac protein), with purified






plasmid DNA containing the cry2Ab gene from B. thuringiensis






subsp. kurstaki.



A-54
1143-14A

Insect resistance (Cry1Ab); WO 2006/128569
Gossypium hirsutum






L. (cotton)


A-55
1143-51B

Insect resistance (Cry1Ab); WO 2006/128570
Gossypium hirsutum






L. (cotton)


A-56
19-51A
DuPont Canada
Introduction of a variant form of acetolactate
Gossypium hirsutum




Agricultural
synthase (ALS).
L. (cotton)




Products




A-57
281-24-236
DOW
Insect-resistant cotton produced by inserting the
Gossypium hirsutum




AgroSciences
cry1F gene from Bacillus thuringiensis var. aizawai.
L. (cotton)




LLC
The PAT encoding gene from Streptomyces






viridochromogenes was introduced as a selectable marker.



A-58
3006-210-23
DOW
Insect-resistant cotton produced by inserting the
Gossypium hirsutum




AgroSciences
cry1Ac gene from Bacillus thuringiensis subsp.
L. (cotton)




LLC
kurstaki. The PAT encoding gene from






Streptomyces viridochromogenes was introduced as






a selectable marker.



A-59
31807/31808
Calgene Inc.
Insect-resistant and bromoxynil herbicide tolerant
Gossypium hirsutum





cotton produced by inserting the cry1Ac gene from
L. (cotton)





Bacillus thuringiensis and a nitrilase encoding gene






from Klebsiella pneumoniae.



A-60
BXN
Calgene Inc.
Bromoxynil herbicide tolerant cotton produced by inserting 
Gossypium hirsutum





a nitrilase encoding gene from Klebsiella pneumoniae.
L. (cotton)


A-61
CE43-67B

Insect resistance (Cry1Ab); WO 2006/128573
Gossypium hirsutum






L. (cotton)


A-62
CE44-69D

Insect resistance (Cry1Ab); WO 2006/128571
Gossypium hirsutum






L. (cotton)


A-63
CE46-02A

Insect resistance (Cry1Ab); WO 2006/128572
Gossypium hirsutum






L. (cotton)


A-64
Cot102

Insect resistance (Vip3A); US 2006-130175
Gossypium hirsutum






L. (cotton)


A-65
COT102
Syngenta
Insect-resistant cotton produced by inserting the
Gossypium hirsutum




Seeds, Inc.
vip3A(a) gene from Bacillus thuringiensis AB88.
L. (cotton)





The APH4 encoding gene from E. coli was






introduced as a selectable marker.



A-66
COT202

Insect resistance (VIP3A); US2009181399
Gossypium hirsutum






L. (cotton)


A-67
Cot202

Insect resistance (VIP3); US 2007-067868
Gossypium hirsutum






L. (cotton)


A-68
DAS-21Ø23-5 ×
DOW
WideStrike TM, a stacked insect-resistant cotton
Gossypium hirsutum



DAS-24236-5
AgroSciences
derived from conventional cross-breeding of
L. (cotton)




LLC
parental lines 3006-210-23 (OECD identifier: DAS-






21Ø23-5) and 281-24-236 (OECD identifier: DAS-24236-5).



A-69
DAS-21Ø23-5 ×
DOW
Stacked insect-resistant and glyphosate-tolerant
Gossypium hirsutum



DAS-24236-5 ×
AgroSciences
cotton derived from conventional cross-breeding of
L. (cotton)



MON88913
LLC and
WideStrike cotton (OECD identifier: DAS-21Ø23-5 ×





Pioneer Hi-
DAS-24236-5) with MON88913, known as





Bred
RoundupReady Flex (OECD identifier: MON-





International
88913-8).





Inc.




A-70
DAS-21Ø23-5 ×
DOW
WideStrike TM/Roundup Ready ® cotton, a stacked
Gossypium hirsutum



DAS-24236-5 ×
AgroSciences
insect-resistant and glyphosate-tolerant cotton
L. (cotton)



MON-Ø1445-2
LLC
derived from conventional cross-breeding of






WideStrike cotton (OECD identifier: DAS-21Ø23-5 ×






DAS-24236-5) with MON1445 (OECD identifier:






MON-Ø1445-2).



A-71
EE-GH3

Glyphosate tolerance; WO 2007/017186
Gossypium hirsutum






L. (cotton)


A-72
T304-40

Insect resistance (Cry1Ab); WO 2008/122406
Gossypium hirsutum






L. (cotton)


A-73
GHB119

Insect resistance (cry2Ae); WO2008151780
Gossypium hirsutum






L. (cotton)


A-74
event 281-24-

Insect resistance (Cry1F); WO 2005/103266
Gossypium hirsutum



236


L. (cotton)


A-75
event3006-210-

Insect resistance (Cry1Ac); WO 2005/103266
Gossypium hirsutum



23


L. (cotton)


A-76
GHB614
Bayer
Glyphosate herbicide tolerant cotton produced by
Gossypium hirsutum




CropScience
inserting 2MEPSPS gene into variety Coker312 by
L. (cotton)




(Aventis
Agrobacterium under the control of Ph4a748At and





CropScience
TpotpC





(AgrEvo))




A-77
LLCotton25
Bayer
Glufosinate ammonium herbicide tolerant cotton
Gossypium hirsutum




CropScience
produced by inserting a modified phosphinothricin
L. (cotton)




(Aventis
acetyltransferase (PAT) encoding gene from the soil





CropScience
bacterium Streptomyces hygroscopicus; WO





(AgrEvo))
2003013224



A-78
LLCotton25 ×
Bayer
Stacked herbicide tolerant and insect resistant cotton
Gossypium hirsutum



MON15985
CropScience
combining tolerance to glufosinate ammonium
L. (cotton)




(Aventis
herbicide from LLCotton25 (OECD identifier: ACS-





CropScience
GHØØ1-3) with resistance to insects from





(AgrEvo))
MON15985 (OECD identifier: MON-15985-7)



A-79
MON 15985

Insect resistance (Cry1A/Cry2Ab); US 2004-250317
Gossypium hirsutum






L. (cotton)


A-80
MON1445/1698
Monsanto
Glyphosate herbicide tolerant cotton produced by
Gossypium hirsutum




Company
inserting a naturally glyphosate tolerant form of the
L. (cotton)





enzyme 5-enolpyruvyl shikimate-3-phosphate






synthase (EPSPS) from A. tumefaciens strain CP4.



A-81
MON15985 ×
Monsanto
Stacked insect resistant and glyphosate tolerant
Gossypium hirsutum



MON88913
Company
cotton produced by conventional cross-breeding of
L. (cotton)





the parental lines MON88913 (OECD identifier:






MON-88913-8) and 15985 (OECD identifier: MON-






15985-7). Glyphosate tolerance is derived from






MON88913 which contains two genes encoding the






enzyme 5-enolypyruvylshikimate-3-phosphate






synthase (EPSPS) from the CP4 strain of






Agrobacterium tumefaciens. Insect resistance is






derived from the line MON15985 which was






produced by transformation of the DP50B parent






variety, which contained event 531 (expressing






Cry1Ac protein), with purified plasmid DNA containing 






the cry2Ab gene from B. thuringiensis subsp. kurstaki.



A-82
MON-15985-7 ×
Monsanto
Stacked insect resistant and herbicide tolerant cotton
Gossypium hirsutum



MON-Ø1445-2
Company
derived from conventional cross-breeding of the
L. (cotton)





parental lines 15985 (OECD identifier: MON-






15985-7) and MON1445 (OECD identifier: MON-Ø1445-2).



A-83
MON531/757/1076
Monsanto
Insect-resistant cotton produced by inserting the
Gossypium hirsutum




Company
cry1Ac gene from Bacillus thuringiensis subsp.
L. (cotton)





kurstaki HD-73 (B.t.k.).



A-84
MON88913
Monsanto
Glyphosate herbicide tolerant cotton produced by
Gossypium hirsutum




Company
inserting two genes encoding the enzyme 5-
L. (cotton)





enolypyruvylshikimate-3-phosphate synthase






(EPSPS) from the CP4 strain of Agrobacterium






tumefaciens; WO 2004/072235



A-85
MON-ØØ531-6 ×
Monsanto
Stacked insect resistant and herbicide tolerant cotton
Gossypium hirsutum



MON-Ø1445-2
Company
derived from conventional cross-breeding of the
L. (cotton)





parental lines MON531 (OECD identifier: MON-






ØØ531-6) and MON1445 (OECD identifier: MON-Ø1445-2).



A-86
PV-GHGT07

Glyphosate tolerance; US 2004-148666
Gossypium hirsutum



(1445)


L. (cotton)


A-87
T304-40

Insect-resistance (Cry1Ab); WO2008/122406
Gossypium hirsutum






L. (cotton)


A-88
T342-142

Insect resistance (Cry1Ab); WO 2006/128568
Gossypium hirsutum






L. (cotton)


A-89
X81359
BASF Inc.
Tolerance to imidazolinone herbicides by selection
Helianthus





of a naturally occurring mutant.
annuus (sunflower)


A-90
RH44
BASF Inc.
Selection for a mutagenized version of the enzyme
Lens culinaris (lentil)





acetohydroxyacid synthase (AHAS), also known as






acetolactate synthase (ALS) or acetolactate pyruvate lyase.



A-91
FP967
University of
A variant form of acetolactate synthase (ALS) was
Linum usitatissimum




Saskatchewan,
obtained from a chlorsulfuron tolerant line of A. thaliana
L. (flax, linseed)




Crop Dev.
and used to transform flax.





Centre




A-92
5345
Monsanto
Resistance to lepidopteran pests through the
Lycopersicon




Company
introduction of the cry1Ac gene from Bacillus
esculentum (tomato)





thuringiensis subsp. Kurstaki.



A-93
8338
Monsanto
Introduction of a gene sequence encoding the
Lycopersicon




Company
enzyme 1-amino-cyclopropane-1-carboxylic acid
esculentum (tomato)





deaminase (ACCd) that metabolizes the precursor of






the fruit ripening hormone ethylene.



A-94
1345-4
DNA Plant
Delayed ripening tomatoes produced by inserting an
Lycopersicon




Technology
additional copy of a truncated gene encoding 1-
esculentum (tomato)




Corporation
aminocyclopropane-1-carboxyllic acid (ACC)






synthase, which resulted in downregulation of the






endogenous ACC synthase and reduced ethylene accumulation.



A-95
35 1 N
Agritope Inc.
Introduction of a gene sequence encoding the
Lycopersicon





enzyme S-adenosylmethionine hydrolase that metabolizes 
esculentum (tomato)





the precursor of the fruit ripening hormone ethylene



A-96
B, Da, F
Zeneca Seeds
Delayed softening tomatoes produced by inserting a
Lycopersicon





truncated version of the polygalacturonase (PG)
esculentum (tomato)





encoding gene in the sense or anti-sense orientation






in order to reduce expression of the endogenous PG






gene, and thus reduce pectin degradation.



A-97
FLAVR SAVR
Calgene Inc.
Delayed softening tomatoes produced by inserting
Lycopersicon





an additional copy of the polygalacturonase (PG)
esculentum (tomato)





encoding gene in the anti-sense orientation in order






to reduce expression of the endogenous PG gene and






thus reduce pectin degradation.



A-98
J101, J163
Monsanto
Glyphosate herbicide tolerant alfalfa (lucerne)
Medicago




Company and
produced by inserting a gene encoding the enzyme
sativa (alfalfa)




Forage
5-enolypyruvylshikimate-3-phosphate synthase





Genetics
(EPSPS) from the CP4 strain of Agrobacterium





International
tumefaciens.



A-99
C/F/93/08-02
Societe
Tolerance to the herbicides bromoxynil and ioxynil
Nicotiana tabacum




National
by incorporation of the nitrilase gene from
L. (tobacco)




d'Exploitation
Klebsiella pneumoniae.





des Tabacs et






Allumettes




A-100
Vector 21-41
Vector
Reduced nicotine content through introduction of a
Nicotiana tabacum




Tobacco Inc.
second copy of the tobacco quinolinic acid
L. (tobacco)





phosphoribosyltransferase (QTPase) in the antisense






orientation. The NPTII encoding gene from E. coli was 






introduced as a selectable marker to identify transformants.



A-101
CL121, CL141,
BASF Inc.
Tolerance to the imidazolinone herbicide,
Oryza sativa (rice)



CFX51

imazethapyr, induced by chemical mutagenesis of






the acetolactate synthase (ALS) enzyme using ethyl






methanesulphonate (EMS).



A-102
GAT-OS2

Glufosinate tolerance; WO 01/83818
Oryza sativa (rice)


A-103
GAT-OS3

Glufosinate tolerance; US 2008-289060
Oryza sativa (rice)


A-104
IMINTA-1,
BASF Inc.
Tolerance to imidazolinone herbicides induced by
Oryza sativa (rice)



IMINTA-4

chemical mutagenesis of the acetolactate synthase






(ALS) enzyme using sodium azide.



A-105
LLRICE06,
Aventis
Glufosinate ammonium herbicide tolerant rice
Oryza sativa (rice)



LLRICE62
CropScience
produced by inserting a modified phosphinothricin






acetyltransferase (PAT) encoding gene from the soil






bacterium Streptomyces hygroscopicus).



A-106
LLRICE601
Bayer
Glufosinate ammonium herbicide tolerant rice
Oryza sativa (rice)




CropScience
produced by inserting a modified phosphinothricin





(Aventis
acetyltransferase (PAT) encoding gene from the soil





CropScience
bacterium Streptomyces hygroscopicus).





(AgrEvo))




A-107
PE-7

Insect resistance (Cry1Ac); WO 2008/114282
Oryza sativa (rice)


A-108
PWC16
BASF Inc.
Tolerance to the imidazolinone herbicide,
Oryza sativa (rice)





imazethapyr, induced by chemical mutagenesis of






the acetolactate synthase (ALS) enzyme using ethyl






methanesulphonate (EMS).



A-109
TT51

Insect resistance (Cry1Ab/Cry1Ac); CN1840655
Oryza sativa (rice)


A-110
C5
United States
Plum pox virus (PPV) resistant plum tree produced
Prunus domestica




Department of
through Agrobacterium-mediated transformation
(plum)




Agriculture -
with a coat protein (CP) gene from the virus.





Agricultural






Research






Service





EH92-527
BASF Plant
Crop composition; Amflora; Unique EU identifier:





Science
BPS-25271-9



A-111
ATBT04-6,
Monsanto
Colorado potato beetle resistant potatoes produced
Solanum tuberosum



ATBT04-27,
Company
by inserting the cry3A gene from Bacillus
L. (potato)



ATBT04-30,

thuringiensis (subsp. tenebrionis).




ATBT04-31,






ATBT04-36,






SPBT02-5,






SPBT02-7





A-112
BT6, BT10,
Monsanto
Colorado potato beetle resistant potatoes produced
Solanum tuberosum



BT12, BT16,
Company
by inserting the cry3A gene from Bacillus
L. (potato)



BT17, BT18,

thuringiensis (subsp. tenebrionis).




BT23





A-113
RBMT15-101,
Monsanto
Colorado potato beetle and potato virus Y (PVY)
Solanum tuberosum



SEMT15-02,
Company
resistant potatoes produced by inserting the cry3A
L. (potato)



SEMT15-15

gene from Bacillus thuringiensis (subsp. tenebrionis)






and the coat protein encoding gene from PVY.



A-114
RBMT21-129,
Monsanto
Colorado potato beetle and potato leafroll virus
Solanum tuberosum



RBMT21-350,
Company
(PLRV) resistant potatoes produced by inserting the
L. (potato)



RBMT22-082

cry3A gene from Bacillus thuringiensis (subsp.






tenebrionis) and the replicase encoding gene from PLRV.



A-115
AP205CL
BASF Inc.
Selection for a mutagenized version of the enzyme
Triticum





acetohydroxyacid synthase (AHAS), also known as
aestivum (wheat)





acetolactate synthase (ALS) or acetolactate pyruvate lyase.



A-116
AP602CL
BASF Inc.
Selection for a mutagenized version of the enzyme
Triticum





acetohydroxyacid synthase (AHAS), also known as
aestivum (wheat)





acetolactate synthase (ALS) or acetolactate pyruvate lyase.



A-117
BW255-2,
BASF Inc.
Selection for a mutagenized version of the enzyme
Triticum



BW238-3

acetohydroxyacid synthase (AHAS), also known as
aestivum (wheat)





acetolactate synthase (ALS) or acetolactate pyruvate lyase.



A-118
BW7
BASF Inc.
Tolerance to imidazolinone herbicides induced by
Triticum





chemical mutagenesis of the acetohydroxyacid
aestivum (wheat)





synthase (AHAS) gene using sodium azide.



A-119
Event 1

Fusarium resistance (trichothecene 3-O-
Triticum





acetyltransferase); CA 2561992
aestivum (wheat)


A-120
JOPLIN1

disease (fungal) resistance (trichothecene 3-O-
Triticum





acetyltransferase); US 2008064032
aestivum (wheat)


A-121
MON71800
Monsanto
Glyphosate tolerant wheat variety produced by
Triticum




Company
inserting a modified 5-enolpyruvylshikimate-3-
aestivum (wheat)





phosphate synthase (EPSPS) encoding gene from the






soil bacterium Agrobacterium tumefaciens, strain CP4.



A-122
SWP965001
Cyanamid
Selection for a mutagenized version of the enzyme
Triticum




Crop
acetohydroxyacid synthase (AHAS), also known as
aestivum (wheat)




Protection
acetolactate synthase (ALS) or acetolactate pyruvate lyase.



A-123
Teal 11A
BASF Inc.
Selection for a mutagenized version of the enzyme
Triticum





acetohydroxyacid synthase (AHAS), also known as
aestivum (wheat)





acetolactate synthase (ALS) or acetolactate pyruvate lyase.



A-124
176
Syngenta
Insect-resistant maize produced by inserting the
Zea mays L. (maize)




Seeds, Inc.
cry1Ab gene from Bacillus thuringiensis subsp.






kurstaki. The genetic modification affords resistance






to attack by the European corn borer (ECB).



A-125
3272

Self processing corn (alpha-amylase); US 2006-230473
Zea mays L. (maize)


A-126
3751IR
Pioneer Hi-
Selection of somaclonal variants by culture of
Zea mays L. (maize)




Bred
embryos on imidazolinone containing media.





International






Inc.




A-127
676, 678, 680
Pioneer Hi-
Male-sterile and glufosinate ammonium herbicide
Zea mays L. (maize)




Bred
tolerant maize produced by inserting genes encoding





International
DNA adenine methylase and phosphinothricin





Inc.
acetyltransferase (PAT) from Escherichia coli and






Streptomyces viridochromogenes, respectively.



A-128
ACS-ZMØØ3-2 ×
Bayer
Stacked insect resistant and herbicide tolerant corn
Zea mays L. (maize)



MON-ØØ81Ø-6
CropScience
hybrid derived from conventional cross-breeding of





(Aventis
the parental lines T25 (OECD identifier: ACS-





CropScience
ZMØØ3-2) and MON810 (OECD identifier: MON-





(AgrEvo))
ØØ81Ø-6).



A-129
B16

Glufosinate resistance; US 2003-126634
Zea mays L. (maize)


A-130
B16 (DLL25)
Dekalb
Glufosinate ammonium herbicide tolerant maize
Zea mays L. (maize)




Genetics
produced by inserting the gene encoding





Corporation
phosphinothricin acetyltransferase (PAT) from






Streptomyces hygroscopicus.



A-131
BT11
Syngenta
Insect-resistant and herbicide tolerant maize
Zea mays L. (maize)



(X4334CBR,
Seeds, Inc.
produced by inserting the cry1Ab gene from




X4734CBR)

Bacillus thuringiensis subsp. kurstaki, and the






phosphinothricin N-acetyltransferase (PAT)






encoding gene from S. viridochromogenes.



A-132
BT11 × MIR604
Syngenta
Stacked insect resistant and herbicide tolerant maize
Zea mays L. (maize)




Seeds, Inc.
produced by conventional cross breeding of parental






lines BT11 (OECD unique identifier: SYN-BTØ11-






1) and MIR604 (OECD unique identifier: SYN-






IR6Ø5-5). Resistance to the European Corn Borer






and tolerance to the herbicide glufosinate






ammonium (Liberty) is derived from BT11, which






contains the cry1Ab gene from Bacillus






thuringiensis subsp. kurstaki, and the






phosphinothricin N-acetyltransferase (PAT)






encoding gene from S. viridochromogenes. Corn






rootworm-resistance is derived from MIR604 which






contains the mcry3A gene from Bacillus thuringiensis.



A-133
BT11 × MIR604 ×
Syngenta
Stacked insect resistant and herbicide tolerant maize
Zea mays L. (maize)



GA21
Seeds, Inc.
produced by conventional cross breeding of parental






lines BT11 (OECD unique identifier: SYN-BTØ11-






1), MIR604 (OECD unique identifier: SYN-IR6Ø5-






5) and GA21 (OECD unique identifier: MON-






ØØØ21-9). Resistance to the European Corn Borer






and tolerance to the herbicide glufosinate






ammonium (Liberty) is derived from BT11, which






contains the cry1Ab gene from Bacillus






thuringiensis subsp. kurstaki, and the






phosphinothricin N-acetyltransferase (PAT)






encoding gene from S. viridochromogenes. Corn






rootworm-resistance is derived from MIR604 which






contains the mcry3A gene from Bacillus






thuringiensis. Tolerance to glyphosate herbcicide is






derived from GA21 which contains a a modified






EPSPS gene from maize.



A-134
CBH-351
Aventis
Insect-resistant and glufosinate ammonium herbicide
Zea mays L. (maize)




CropScience
tolerant maize developed by inserting genes






encoding Cry9C protein from Bacillus thuringiensis






subsp tolworthi and phosphinothricin






acetyltransferase (PAT) from Streptomyces hygroscopicus.



A-135
DAS-06275-8
DOW
Lepidopteran insect resistant and glufosinate
Zea mays L. (maize)




AgroSciences
ammonium herbicide-tolerant maize variety





LLC
produced by inserting the cry1F gene from Bacillus






thuringiensis var aizawai and the phosphinothricin






acetyltransferase (PAT) from Streptomyces hygroscopicus.



A-136
DAS-59122-7
DOW
Corn rootworm-resistant maize produced by
Zea mays L. (maize)




AgroSciences
inserting the cry34Ab1 and cry35Ab1 genes from





LLC and
Bacillus thuringiensis strain PS149B1. The PAT





Pioneer Hi-
encoding gene from Streptomyces





Bred
viridochromogenes was introduced as a selectable





International
marker; US 2006-070139





Inc.




A-137
DAS-59122-7 ×
DOW
Stacked insect resistant and herbicide tolerant maize
Zea mays L. (maize)



NK603
AgroSciences
produced by conventional cross breeding of parental





LLC and
lines DAS-59122-7 (OECD unique identifier: DAS-





Pioneer Hi-
59122-7) with NK603 (OECD unique identifier:





Bred
MON-ØØ6Ø3-6). Corn rootworm-resistance is





International
derived from DAS-59122-7 which contains the





Inc.
cry34Ab1 and cry35Ab1 genes from Bacillus






thuringiensis strain PS149B1. Tolerance to






glyphosate herbcicide is derived from NK603.



A-138
DAS-59122-7 ×
DOW
Stacked insect resistant and herbicide tolerant maize
Zea mays L. (maize)



TC1507 ×
AgroSciences
produced by conventional cross breeding of parental




NK603
LLC and
lines DAS-59122-7 (OECD unique identifier: DAS-





Pioneer Hi-
59122-7) and TC1507 (OECD unique identifier:





Bred
DAS-Ø15Ø7-1) with NK603 (OECD unique





International
identifier: MON-ØØ6Ø3-6). Corn rootworm-





Inc.
resistance is derived from DAS-59122-7 which






contains the cry34Ab1 and cry35Ab1 genes from






Bacillus thuringiensis strain PS149B1. Lepidopteran






resistance and toleraance to glufosinate ammonium






herbicide is derived from TC1507. Tolerance to






glyphosate herbcicide is derived from NK603.



A-139
DAS-Ø15Ø7-1 ×
DOW
Stacked insect resistant and herbicide tolerant maize
Zea mays L. (maize)



MON-ØØ6Ø3-6
AgroSciences
derived from conventional cross-breeding of the





LLC
parental lines 1507 (OECD identifier: DAS-Ø15Ø7-






1) and NK603 (OECD identifier: MON-ØØ6Ø3-6).



A-140
DBT418
Dekalb
Insect-resistant and glufosinate ammonium herbicide
Zea mays L. (maize)




Genetics
tolerant maize developed by inserting genes





Corporation
encoding Cry1AC protein from Bacillus






thuringiensis subsp kurstaki and phosphinothricin






acetyltransferase (PAT) from Streptomyces hygroscopicus



A-141
DK404SR
BASF Inc.
Somaclonal variants with a modified acetyl-CoA-
Zea mays L. (maize)





carboxylase (ACCase) were selected by culture of






embryos on sethoxydim enriched medium.



A-142
DP-098140-6

Glyphosate tolerance/ALS inhibitor tolerance; WO 2008/112019
Zea mays L. (maize)


A-143
DP-Ø9814Ø-6
Pioneer Hi-
Corn line 98140 was genetically engineered to
Zea mays L. (maize)



(Event 98140)
Bred
express the GAT4621 (glyphosate acetyltransferase)





International
and ZM-HRA (modified version of a maize





Inc.
acetolactate synthase) proteins. The GAT4621






protein, encoded by the gat4621 gene, confers






tolerance to glyphosate-containing herbicides by






acetylating glyphosate and thereby rendering it non-






phytotoxic. The ZM-HRA protein, encoded by the






zm-hra gene, confers tolerance to the ALS-inhibiting






class of herbicides.



A-144
Event 3272
Syngenta
Maize line expressing a heat stable alpha-amylase
Zea mays L. (maize)




Seeds, Inc.
gene amy797E for use in the dry-grind ethanol






production process. The phosphomannose isomerase






gene from E. coli was used as a selectable marker.



A-145
EXP1910IT
Syngenta
Tolerance to the imidazolinone herbicide,
Zea mays L. (maize)




Seeds, Inc.
imazethapyr, induced by chemical mutagenesis of





(formerly
the acetolactate synthase (ALS) enzyme using ethyl





Zeneca Seeds)
methanesulphonate (EMS).



A-146
FI117

Glyphosate resistance; U.S. Pat. No. 6,040,497
Zea mays L. (maize)


A-147
GA21
Monsanto
Induction, by particle bombardment, of a modified
Zea mays L. (maize)




Company
5-enolpyruvyl shikimate-3-phosphate synthase






(EPSPS), an enzyme involved in the shikimate






biochemical pathway for the production of the






aromatic amino acids.



A-148
GAT-ZM1

Glufosinate tolerance; WO 01/51654
Zea mays L. (maize)


A-149
GG25

Glyphosate resistance; U.S. Pat. No. 6,040,497
Zea mays L. (maize)


A-150
GJ11

Glyphosate resistance; U.S. Pat. No. 6,040,497
Zea mays L. (maize)


A-151
IT
Pioneer Hi
Tolerance to the imidazolinone herbicide,
Zea mays L. (maize)




Bred
imazethapyr, was obtained by in vitro selection of





International
somaclonal variants.





Inc.




A-152
LY038
Monsanto
Altered amino acid composition, specifically
Zea mays L. (maize)




Company
elevated levels of lysine, through the introduction of






the cordapA gene, derived from Corynebacterium






glutamicum, encoding the enzyme






dihydrodipicolinate synthase (cDHDPS); U.S. Pat. No.






7,157,281



A-153
MIR162

Insect resistance; WO 2007142840
Zea mays L. (maize)


A-154
MIR604
Syngenta
Corn rootworm resistant maize produced by
Zea mays L. (maize)




Seeds, Inc.
transformation with a modified cry3A gene. The






phosphomannose isomerase gene from E. coli was






used as a selectable marker; (Cry3a055); EP 1 737 290



A-155
MIR604 × GA21
Syngenta
Stacked insect resistant and herbicide tolerant maize
Zea mays L. (maize)




Seeds, Inc.
produced by conventional cross breeding of parental






lines MIR604 (OECD unique identifier: SYN-






IR6Ø5-5) and GA21 (OECD unique identifier:






MON-ØØØ21-9). Corn rootworm-resistance is






derived from MIR604 which contains the mcry3A






gene from Bacillus thuringiensis. Tolerance to






glyphosate herbcicide is derived from GA21.



A-156
MON80100
Monsanto
Insect-resistant maize produced by inserting the
Zea mays L. (maize)




Company
cry1Ab gene from Bacillus thuringiensis subsp.






kurstaki. The genetic modification affords resistance






to attack by the European corn borer (ECB).



A-157
MON802
Monsanto
Insect-resistant and glyphosate herbicide tolerant
Zea mays L. (maize)




Company
maize produced by inserting the genes encoding the






Cry1Ab protein from Bacillus thuringiensis and the






5-enolpyruvylshikimate-3-phosphate synthase






(EPSPS) from A. tumefaciens strain CP4.



A-158
MON809
Pioneer Hi-
Resistance to European corn borer (Ostrinia
Zea mays L. (maize)




Bred
nubilalis) by introduction of a synthetic cry1Ab





International
gene. Glyphosate resistance via introduction of the





Inc.
bacterial version of a plant enzyme, 5-enolpyruvyl






shikimate-3-phosphate synthase (EPSPS).



A-159
MON810
Monsanto
Insect-resistant maize produced by inserting a
Zea mays L. (maize)




Company
truncated form of the cry1Ab gene from Bacillus






thuringiensis subsp. kurstaki HD-1. The genetic






modification affords resistance to attack by the






European corn borer (ECB); US 2004-180373



A-160
MON810 ×
Monsanto
Stacked insect resistant and glyphosate tolerant
Zea mays L. (maize)



MON88017
Company
maize derived from conventional cross-breeding of






the parental lines MON810 (OECD identifier:






MON-ØØ81Ø-6) and MON88017 (OECD






identifier: MON-88Ø17-3). European corn borer






(ECB) resistance is derived from a truncated form of






the cry1Ab gene from Bacillus thuringiensis subsp.






kurstaki HD-1 present in MON810. Corn rootworm






resistance is derived from the cry3Bb1 gene from






Bacillus thuringiensis subspecies kumamotoensis






strain EG4691 present in MON88017. Glyphosate






tolerance is derived from a 5-enolpyruvylshikimate-






3-phosphate synthase (EPSPS) encoding gene from






Agrobacterium tumefaciens strain CP4 present in MON88017.



A-161
MON832
Monsanto
Introduction, by particle bombardment, of
Zea mays L. (maize)




Company
glyphosate oxidase (GOX) and a modified 5-






enolpyruvyl shikimate-3-phosphate synthase






(EPSPS), an enzyme involved in the shikimate






biochemical pathway for the production of the






aromatic amino acids.



A-162
MON863
Monsanto
Corn root worm resistant maize produced by
Zea mays L. (maize)




Company
inserting the cry3Bb1 gene from Bacillus






thuringiensis subsp. kumamotoensis.



A-163
MON87460

Drought tolerance; water deficit tolerance; WO 2009/111263
Zea mays L. (maize)


A-164
MON88017
Monsanto
Corn rootworm-resistant maize produced by
Zea mays L. (maize)




Company
inserting the cry3Bb1 gene from Bacillus






thuringiensis subspecies kumamotoensis strain






EG4691. Glyphosate tolerance derived by inserting






a 5-enolpyruvylshikimate-3-phosphate synthase






(EPSPS) encoding gene from Agrobacterium






tumefaciens strain CP4; WO2005059103



A-165
MON89034
Monsanto
Maize event expressing two different insecticidal
Zea mays L. (maize)




Company
proteins from Bacillus thuringiensis providing






resistance to a number of lepidopteran pests; insect






resistance (Lepidoptera-Cry1A.105-Cry2Ab); WO 2007140256



A-166
MON89034 ×
Monsanto
Stacked insect resistant and glyphosate tolerant
Zea mays L. (maize)



MON88017
Company
maize derived from conventional cross-breeding of






the parental lines MON89034 (OECD identifier:






MON-89Ø34-3) and MON88017 (OECD






identifier: MON-88Ø17-3). Resistance to






Lepiopteran insects is derived from two crygenes






present in MON89043. Corn rootworm resistance is






derived from a single cry gene and glyphosate






tolerance is derived from the 5-






enolpyruvylshikimate-3-phosphate synthase






(EPSPS) encoding gene from Agrobacterium






tumefaciens present in MON88017.



A-167
MON-ØØ6Ø3-6 ×
Monsanto
Stacked insect resistant and herbicide tolerant corn
Zea mays L. (maize)



MON-ØØ81Ø-6
Company
hybrid derived from conventional cross-breeding of






the parental lines NK603 (OECD identifier: MON-






ØØ6Ø3-6) and MON810 (OECD identifier: MON-ØØ81Ø-6).



A-168
MON-ØØ81Ø-6 ×
Monsanto
Stacked insect resistant and enhanced lysine content
Zea mays L. (maize)



LY038
Company
maize derived from conventional cross-breeding of






the parental lines MON810 (OECD identifier:






MON-ØØ81Ø-6) and LY038 (OECD identifier:






REN-ØØØ38-3).



A-169
MON-ØØ863-5 ×
Monsanto
Stacked insect resistant and herbicide tolerant corn
Zea mays L. (maize)



MON-ØØ6Ø3-6
Company
hybrid derived from conventional cross-breeding of






the parental lines MON863 (OECD identifier: MON-






ØØ863-5) and NK603 (OECD identifier: MON-ØØ6Ø3-6).



A-170
MON-ØØ863-5 ×
Monsanto
Stacked insect resistant corn hybrid derived from
Zea mays L. (maize)



MON-ØØ81Ø-6
Company
conventional cross-breeding of the parental lines






MON863 (OECD identifier: MON-ØØ863-5) and






MON810 (OECD identifier: MON-ØØ81Ø-6)



A-171
MON-ØØ863-5 ×
Monsanto
Stacked insect resistant and herbicide tolerant corn
Zea mays L. (maize)



MON-ØØ81Ø-
Company
hybrid derived from conventional cross-breeding of




6 × MON-

the stacked hybrids MON-ØØ863-5 × MON-




ØØ6Ø3-6

ØØ81Ø-6 and NK603 (OECD identifier: MON-ØØ6Ø3-6).



A-172
MON-ØØØ21-9 ×
Monsanto
Stacked insect resistant and herbicide tolerant corn
Zea mays L. (maize)



MON-ØØ81Ø-6
Company
hybrid derived from conventional cross-breeding of






the parental lines GA21 (OECD identifider: MON-






ØØØ21-9) and MON810 (OECD identifier: MON-ØØ81Ø-6).



A-173
MS3
Bayer
Male sterility caused by expression of the barnase
Zea mays L. (maize)




CropScience
ribonuclease gene from Bacillus amyloliquefaciens;





(Aventis
PPT resistance was via PPT-acetyltransferase





CropScience
(PAT).





(AgrEvo))




A-174
MS6
Bayer
Male sterility caused by expression of the barnase
Zea mays L. (maize)




CropScience
ribonuclease gene from Bacillus amyloliquefaciens;





(Aventis
PPT resistance was via PPT-acetyltransferase





CropScience
(PAT).





(AgrEvo))




A-175
NK603
Monsanto
Introduction, by particle bombardment, of a
Zea mays L. (maize)




Company
modified 5-enolpyruvyl shikimate-3-phosphate






synthase (EPSPS), an enzyme involved in the






shikimate biochemical pathway for the production of






the aromatic amino acids.



A-176
PV-ZMGT32

Glyphosate tolerance; US 2007-056056
Zea mays L. (maize)



(NK603)





A-177
PV-

Glyphosate tolerance; US 2007292854
Zea mays L. (maize)



ZMGT32(nk603)





A-178
PV-ZMIR13

Insect resistance (Cry3Bb); US 2006-095986
Zea mays L. (maize)



(MON863)





A-179
SYN-BTØ11-1 ×
Syngenta
Stacked insect resistant and herbicide tolerant maize
Zea mays L. (maize)



MON-ØØØ21-9
Seeds, Inc.
produced by conventional cross breeding of parental






lines BT11 (OECD unique identifier: SYN-BTØ11-






1) and GA21 (OECD unique identifier: MON-ØØØ21-9).



A-180
T14, T25
Bayer
Glufosinate herbicide tolerant maize produced by
Zea mays L. (maize)




CropScience
inserting the phosphinothricin N-acetyltransferase





(Aventis
(PAT) encoding gene from the aerobic actinomycete





CropScience
Streptomyces viridochromogenes.





(AgrEvo))




A-181
TC1507
Mycogen (c/o
Insect-resistant and glufosinate ammonium herbicide
Zea mays L. (maize)




Dow
tolerant maize produced by inserting the cry1F gene





AgroSciences);
from Bacillus thuringiensis var. aizawai and the





Pioneer (c/o
phosphinothricin N-acetyltransferase encoding gene





Dupont)
from Streptomyces viridochromogenes.



A-182
TC1507 × DAS-
DOW
Stacked insect resistant and herbicide tolerant maize
Zea mays L. (maize)



59122-7
AgroSciences
produced by conventional cross breeding of parental





LLC and
lines TC1507 (OECD unique identifier: DAS-





Pioneer Hi-
Ø15Ø7-1) with DAS-59122-7 (OECD unique





Bred
identifier: DAS-59122-7). Resistance to





International
lepidopteran insects is derived from TC1507 due to





Inc.
the presence of the cry1F gene from Bacillus






thuringiensis var. aizawai. Corn rootworm-resistance






is derived from DAS-59122-7 which contains the






cry34Ab1 and cry35Ab1 genes from Bacillus






thuringiensis strain PS149B1. Tolerance to






glufosinate ammonium herbcicide is derived from






TC1507 from the phosphinothricin N-






acetyltransferase encoding gene from Streptomyces






viridochromogenes.



A-183
VIP1034

Insect resistance; WO 03/052073
Zea mays L. (maize)









In one embodiment of the invention, the plants A-1 to A-183 of Table A, in total, or parts thereof, or propagation material of said plants are treated or contacted with the active compound combinations of the invention.







TABLE B







Non-exhaustive list of transgenic plants to work the invention from the APHIS database


of the United States Department of Agriculture (USDA). The database can be found on:


http://www.aphis.usda.gov/animal_welfare/efoia/index.shtml.















Extension



EA find




of Petition


Trans-formation
conclusion &


No.
Petition
Number
Institution
Plant
Event or Line
determination





B-1
10-070-01p

Virginia Tech
Peanut
Sclerotinia blight
N70, P39, and







resistant
W171


B-2
09-349-01p

Dow
Soya bean
2,4-D and
DAS-68416-4





AgroSciences

glufosinate








tolerant



B-3
09-328-01p

Bayer Crop
Soya bean
glyphosate and
FG72





Science

isoxaflutole








tolerant



B-4
09-233-01p

Dow
Corn
2,4-D and
DAS-40278-9







ACCase-inhibitor








tolerant



B-5
09-201-01p

Monsanto
Soya bean
improved fatty
MON-877Ø5-6







acid profile



B-6
09-183-01p

Monsanto
Soya bean
stearidonic acid
MON-87769







produced



B-7
09-082-01p

Monsanto
Soya bean
Lepidopteran
MON 87701







resistant



B-8
09-063-01p

Stine Seed
Corn
Glyphosate
HCEM485







tolerant



B-9
09-055-01p

Monsanto
Corn
Drought Tolerant
MON 87460


B-10
09-015-01p

BASF Plant
Soya bean
imidazolinone
BPS-CV127-9





Science, LLC

tolerant
Soya bean


B-11
08-366-01p

ArborGen
Eucalyptus
Freeze Tolerant,
ARB-FTE1-08







Fertility Altered



B-12
08-340-01p

Bayer
Cotton
Glufosinate
T304-







Tolerant, Insect
40XGHB 119







Resistant



B-13
08-338-01p

Pioneer
Corn
Male Sterile,
DP-32138-1







Fertility Restored,








Visual Marker



B-14
08-315-01p

Florigene
Rose
Altered Flower
IFD-524Ø1-4







Color
and IFD-529Ø1-








9


B-15
07-108-01p

Syngenta
Cotton
Lepidopteran
COT67B







Resistant



B-16
06-354-01p

Pioneer
Soya bean
High Oleic Acid
DP-3Ø5423-1


B-17








B-18
05-280-01p

Syngenta
Corn
Thermostable
3272


B-19




alpha-amylase



B-20
04-110-01p

Monsanto &
Alfalfa
Glyphosate
J101, J163


B-21


Forage

Tolerant



B-22


Genetics





B-23








B-24
03-104-01p

Monsanto &
Creeping
Glyphosate
ASR368


B-25


Scotts
bentgrass
Tolerant



B-26








B-27








B-28








B-29








B-30
07-253-01p

Syngenta
Corn
Lepidopteran
MIR-162 Maize


B-31




resistant



B-32
07-152-01p

Pioneer
Corn
glyphosate &
DP-098140-6


B-33




Imidazolinone








tolerant



B-34
04-337-01p

University of
Papaya
Papaya Ringspot
X17-2


B-35


Florida

Virus Resistant



B-36
06-332-01p

Bayer
Cotton
Glyphosate
GHB614


B-37


CropScience

tolerant



B-38
06-298-01p

Monsanto
Corn
European Corn
MON 89034


B-39




Borer resistant



B-40
06-271-01p

Pioneer
Soya bean
Glyphosate &
356043


B-41




acetolactate
(DP 356Ø43-5)







synthase tolerant



B-42
06-234-01p
98-329-01p
Bayer
Rice
Phosphinothricin
LLRICE601


B-43


CropScience

tolerant



B-44
06-178-01p

Monsanto
Soya bean
Glyphosate
MON 89788


B-45




tolerant



B-46
04-362-01p

Syngenta
Corn
Corn Rootworm
MIR604


B-47




Protected



B-48








B-49
04-264-01p

ARS
Plum
Plum Pox Virus
C5


B-50




Resistant



B-51
04-229-01p

Monsanto
Corn
High Lysine
LY038


B-52








B-53
04-125-01p

Monsanto
Corn
Corn Rootworm
88017


B-54




Resistant



B-55
04-086-01p

Monsanto
Cotton
Glyphosate
MON 88913


B-56




Tolerant



B-57








B-58
03-353-01p

Dow
Corn
Corn Rootworm
59122


B-59




Resistant



B-60
03-323-01p

Monsanto
Sugar Beet
Glyphosate
H7-1


B-61




Tolerant
TC-6275


B-62
03-181-01p
00-136-01p
Dow
Corn
Lepidopteran



B-63




Resistant &








Phosphinothricin








tolerant



B-64
03-155-01p

Syngenta
Cotton
Lepidopteran
COT 102


B-65




Resistant



B-66
03-036-01p

Mycogen/Dow
Cotton
Lepidopteran
281-24-236


B-67




Resistant



B-68
03-036-02p

Mycogen/Dow
Cotton
Lepidopteran
3006-210-23


B-69




Resistant



B-70
02-042-01p

Aventis
Cotton
Phosphinothricin
LLCotton25







tolerant



B-71
01-324-01p
98-216-01p
Monsanto
Rapeseed
Glyphosate
RT200







tolerant



B-72
01-206-01p
98-278-01p
Aventis
Rapeseed
Phosphinothricin
MS1 & RF1/RF2







tolerant &








pollination








control



B-73
01-206-02p
97-205-01p
Aventis
Rapeseed
Phosphinothricin
Topas19/2







tolerant



B-74
01-137-01p

Monsanto
Corn
Corn Rootworm
MON 863







Resistant



B-75
01-121-01p

Vector
Tobacco
Reduced nicotine
Vector 21-41


B-76
00-342-01p

Monsanto
Cotton
Lepidopteran
Cotton Event







resistant
15985


B-77
00-136-01p

Mycogen c/o
Corn
Lepidopteran
Line 1507





Dow &

resistant






Pioneer

phosphinothricin








tolerant



B-78
00-011-01p
97-099-01p
Monsanto
Corn
Glyphosate
NK603







tolerant



B-79
99-173-0 1p 
97-204-01p
Monsanto
Potato
PLRV & CPB
RBMT22-82







resistant



B-80
98-349-01p
95-228-01p
AgrEvo
Corn
Phosphinothricin
MS6







tolerant and Male








sterile



B-81
98-335-01p

U. of
Flax
Tolerant to soil
CDC Triffid





Saskatchewan

residues of








sulphonyl urea








herbicide



B-82
98-329-01p

AgrEvo
Rice
Phosphinothricin
LLRICE06,







tolerant
LLRICE62


B-83
98-278-01p

AgrEvo
Rapeseed
Phosphinothricin
MS8 & RF3







tolerant &








Pollination








control



B-84
98-238-01p

AgrEvo
Soya bean
Phosphinothricin
GU262







tolerant



B-85
98-216-01p

Monsanto
Rapeseed
Glyphosate
RT73







tolerant



B-86
98-173-01p

Novartis Seeds
Beet
Glyphosate
GTSB77





& Monsanto

tolerant



B-87
98-014-01p
96-068-01p
AgrEvo
Soya bean
Phosphinothricin
A5547-127







tolerant



B-88
97-342-01p

Pioneer
Corn
Male sterile &
676, 678, 680







Phosphinothricin








tolerant



B-89
97-339-01p

Monsanto
Potato
CPB & PVY
RBMT15-101,







resistant
SEMT15-02,








SEMT15-15


B-90
97-336-01p

AgrEvo
Beet
Phosphinothricin
T-120-7







tolerant



B-91
97-287-01p

Monsanto
Tomato
Lepidopteran
5345







resistant



B-92
97-265-01p

AgrEvo
Corn
Phosphinothricin
CBH-351







tolerant &








Lepidopteran








resistant



B-93
97-205-01p

AgrEvo
Rapeseed
Phosphinothricin
T45







tolerant



B-94
97-204-01p

Monsanto
Potato
CPB & PLRV
RBMT21-129 &







resistant
RBMT21-350


B-95
97-148-01p

Bejo
Cichorium
Male sterile
RM3-3, RM3-4,






intybus

RM3-6


B-96
97-099-01p

Monsanto
Corn
Glyphosate
GA21







tolerant



B-97
97-013-01p

Calgene
Cotton
Bromoxynil
Events 31807 &







tolerant &
31808







Lepidopteran








resistant



B-98
97-008-01p

Du Pont
Soya bean
Oil profile altered
G94-1, G94-19,








G-168


B-99
96-317-01p

Monsanto
Corn
Glyphosate
MON802







tolerant & ECB








resistant



B-100
96-291-01p

DeKalb
Corn
European Corn
DBT418







Borer resistant



B-101
96-248-01p
92-196-01p
Calgene
Tomato
Fruit ripening
1 additional







altered
FLAVRSAVR








line


B-102
96-068-01p

AgrEvo
Soya bean
Phosphinothricin
W62, W98,







tolerant
A2704-12,








A2704-21,








A5547-35


B-103
96-051-01p

Cornell U
Papaya
PRSV resistant
55-1, 63-1


B-104
96-017-01p
95-093-01p
Monsanto
Corn
European Corn
MON809 &







Borer resistant
MON810


B-105
95-352-01p

Asgrow
Squash
CMV, ZYMV,
CZW-3







WMV2 resistant



B-106
95-338-01p

Monsanto
Potato
CPB resistant
SBT02-5 & -7,








ATBT04-6 &-








27, -30, -31, -36


B-107
95-324-01p

Agritope
Tomato
Fruit ripening
35 1 N







altered



B-108
95-256-01p

Du Pont
Cotton
Sulfonylurea
19-51a







tolerant



B-109
95-228-01p

Plant Genetic
Corn
Male sterile
MS3





Systems





B-110
95-195-01p

Northrup King
Corn
European Corn
Bt11







Borer resistant



B-111
95-179-01p
92-196-01p
Calgene
Tomato
Fruit ripening
2 additional







altered
FLAVRSAVR








lines


B-112
95-145-01p

DeKalb
Corn
Phosphinothricin
B16







tolerant



B-113
95-093-01p

Monsanto
Corn
Lepidopteran
MON 80100







resistant



B-114
95-053-01p

Monsanto
Tomato
Fruit ripening
8338







altered



B-115
95-045-01p

Monsanto
Cotton
Glyphosate
1445, 1698







tolerant



B-116
95-030-01p
92-196-01p
Calgene
Tomato
Fruit ripening
20 additional







altered
FLAVRSAVR








lines


B-117
94-357-01p

AgrEvo
Corn
Phosphinothricin
T14, T25







tolerant



B-118
94-319-01p

Ciba Seeds
Corn
Lepidopteran
Event 176







resistant



B-119
94-308-01p

Monsanto
Cotton
Lepidopteran
531, 757, 1076







resistant



B-120
94-290-01p

Zeneca &
Tomato
Fruit
B, Da, F





Petoseed

polygalacturonase








level decreased



B-121
94-257-01p

Monsanto
Potato
Coleopteran
BT6, BT10,







resistant
BT12, BT16,








BT17, BT18,








BT23


B-122
94-230-01p
92-196-01p
Calgene
Tomato
Fruit ripening
9 additional







altered
FLAVRSAVR








lines


B-123
94-228-01p

DNA Plant
Tomato
Fruit ripripening
1345-4





Tech

altered



B-124
94-227-01p
92-196-01p
Calgene
Tomato
Fruit ripening
Line N73 1436-







altered
111


B-125
94-090-01p

Calgene
Rapeseed
Oil profile altered
pCGN3828-








212/86- 18 & 23


B-126
93-258-01p

Monsanto
Soya bean
Glyphosate
40-3-2







tolerant



B-127
93-196-01p

Calgene
Cotton
Bromoxynil
BXN







tolerant



B-128
92-204-01p

Upjohn
Squash
WMV2 & ZYMV
ZW-20







resistant



B-129
92-196-01p

Calgene
Tomato
Fruit ripening
FLAVR SAVR







altered





Abbreviations used in this table:


CMV-cucumber mosaic virus


CPB-colorado potato beetle


PLRV- potato leafroll virus


PRSV-papaya ringspot virus


PVY-potato virus Y


WMV2- watermelon mosaic virus 2


ZYMV-zucchini yellow mosaic virus






In one embodiment of the invention, the plants B-1 to B-129 of Table B, in total, or parts thereof, or propagation material of said plants are treated or contacted with the active compound combinations of the invention.







TABLE C







Non-exhaustive list of traits to work the invention with reference to


documents in which they are described.











No.
Trait
Reference







C-1
Water use efficiency
WO 2000/073475





WO2009/150541



C-2
Nitrogen use efficiency
WO 1995/009911





WO 1997/030163





WO 2007/092704





WO 2007/076115





WO 2005/103270





WO 2002/002776





WO2008/051608





WO2008/112613





WO2009/015096





WO2009/061776





WO2009/105492





WO2009/105612





WO2009/117853





WO2010/006010





WO2009/117853





WO2009/061776





WO2009/015096





WO2009/105492





WO2009/105612





WO2010/006010





WO2010/007496



C-3
Improved photosynthesis
WO 2008/056915





WO 2004/101751



C-4
Nematode resistance
WO 1995/020669





WO 2001/051627





WO 2008/139334





WO 2008/095972





WO 2006/085966





WO 2003/033651





WO 1999/060141





WO 1998/012335





WO 1996/030517





WO 1993/018170





WO2008/095886





WO2008/095887





WO2008/095888





WO2008/095889





WO2008/095910





WO2008/095911





WO2008/095916





WO2008/095919





WO2008/095969





WO2008/095970





WO2008/095972





WO2008/110522





WO2008/139334





WO2008/152008





WO2009/000736





WO2009/065863





WO2009/112505





WO2009/132089





WO2010/023186





WO2010/025172





WO2010/027793





WO2010/027799





WO2010/027804





WO2010/027805





WO2010/027808





WO2010/027809



C-5
Reduced pod dehiscence
WO 2006/009649





WO 2004/113542





WO 1999/015680





WO 1999/000502





WO 1997/013865





WO 1996/030529





WO 1994/023043



C-6
Aphid resistance
WO 2006/125065





WO 1997/046080





WO 2008/067043





WO 2004/072109





WO2009/091860





WO 2009021153





WO2010036764



C-7
Sclerotinia resistance
WO 2006/135717





WO 2006/055851





WO 2005/090578





WO 2005/000007





WO 2002/099385





WO 2002/061043



C-8
Botrytis resistance
WO 2006/046861





WO 2002/085105



C-9
Bremia resistance
US 20070022496





WO 2000/063432





WO 2004/049786





WO2009/111627



C10
Erwinia resistance
WO 2004/049786



C-11
Closterovirus resistance
WO 2007/073167





WO 2007/053015





WO 2002/022836



C-12
Stress tolerance (including
WO 2010/019838




drought tolerance)
WO 2009/049110





WO2008/002480





WO2005/033318





WO2008/002480





WO2008/005210





WO2008/006033





WO2008/008779





WO2008/022486





WO2008/025097





WO2008/027534





WO2008/027540





WO2008/037902





WO2008/046069





WO2008/053487





WO2008/057642





WO2008/061240





WO2008/064222





WO2008/064341





WO2008/073617





WO2008/074025





WO2008/076844





WO2008/096138





WO2008/110848





WO2008/116829





WO2008/117537





WO2008/121320





WO2008/125245





WO2008/142034





WO2008/142036





WO2008/150165





WO2008/092935





WO2008/145675





WO2009/010460





WO2009/016240





WO2009/031664





WO2009/038581





WO2009/049110





WO2009/053511





WO2009/054735





WO2009/067580





WO2009/073605





WO2009/077611





WO2009/079508





WO2009/079529





WO2009/083958





WO2009/086229





WO2009/092009





WO2009/094401





WO2009/094527





WO2009/102965





WO2009/114733





WO2009/117448





WO2009/126359





WO2009/126462





WO2009/129162





WO2009/132057





WO2009/141824





WO2009/148330





WO2010/037714





WO2010/031312





WO2010/006010





WO2010/007495





WO2010/019838





WO2010/025513



C-13
Tobamovirus resistance
WO 2006/038794





WO2002081713





WO2009086850



C-14
Harvest yield
WO2008/125983A2





WO2008/112613A1





WO2008/118394A1





WO2008/015263A2





WO2008/021021A2





WO2008/043849A2





WO2008/044150A2





WO2008/049183A1





WO2008/056915A1





WO2008/059048A1





WO2008/062049A1





WO2008/071767A1





WO2008/074891A2





WO2008/087932A1





WO2008/092910A1





WO2008/092935A2





WO2008/104598A2





WO2008/111779A1





WO2008/122980A2





WO2008/135206A2





WO2008/135467A2





WO2008/135603A2





WO2008/137108A2





WO2008/138975A1





WO2008/142146A1





WO2008/142163A2





WO2008/145629A2





WO2008/145675A2





WO2008/145761A1





WO2008/148872A1





WO2008/073617A2





WO2009//127671A1





WO2009/0 65912A2





WO2009/000789A1





WO2009/000848A1





WO2009/000876A1





WO2009/003977A2





WO2009/009142A2





WO2009/012467A2





WO2009/013225A2





WO2009/013263A2





WO2009/014665A2





WO2009/016104A1





WO2009/016212A2





WO2009/016232A2





WO2009/021548A1





WO2009/034188A1





WO2009/037279A1





WO2009/037329A2





WO2009/037338A1





WO2009/040665A2





WO2009/056566A2





WO2009/060040A1





WO2009/068564A1





WO2009/068588A2





WO2009/072676A1





WO2009/073069A2





WO2009/075860A2





WO2009/077973A1





WO2009/080743A2





WO2009/080802A2





WO2009/091518A2





WO2009/092772A2





WO2009/095455A1





WO2009/095641A2





WO2009/095881A2





WO2009/097133A2





WO2009/102978A2





WO2009/106596A2





WO2009/108513A2





WO2009/113684A1





WO2009/134339A2





WO2009/135130A2





WO2009/135810A1





WO2009/145290A1





WO2009/150170A1





WO2009/153208A1





WO2009/156360A1





WO2010/012796A1





WO2010/003917A1





WO2010/037228A1





WO2010/000794A1





WO2010/005298A2





WO2010/006732A2





WO2010/007035A1





WO2010/007496A2





WO2010/012760A2





WO2010/019872A1





WO2010/023310A2





WO2010/023320A2





WO2010/025465A1





WO2010/025466A2





WO2010/028205A1





WO2010/028456A1





WO2010/033564A1





WO2010/034652A1





WO2010/034672A1





WO2010/034681A1





WO2010/035784A1





WO2010/036866A1





WO2010/039750A2










In one embodiment of the invention, the plants comprising or expressing traits of C-1 to C-14 of Table C, in total, or parts thereof, or propagation material of said plants are treated or contacted with the active compound combinations of the invention.







TABLE D







Non-exhaustive list of transgenic events and traits the invention can be worked


on with reference to patent applications.












Plant





No.
species
Transgenic event
Trait
Patent reference





D-1
Maize
PV-ZMGT32
Glyphosate tolerance
US 2007-056056




(NK603)


D-2
Maize
MIR604
Insect resistance
EP-A 1 737 290





(Cry3a055)


D-3
Maize
LY038
High lysine content
U.S. Pat. No. 7,157,281


D-4
Maize
3272
Self processing corn
US 2006-230473





(alpha-amylase)


D-5
Maize
PV-ZMIR13
Insect resistance (Cry3Bb)
US 2006-095986




(MON863)


D-6
Maize
DAS-59122-7
Insect resistance
US 2006-070139





(Cry34Ab1/Cry35Ab1)


D-7
Maize
TC1507
Insect resistance (Cry1F)
U.S. Pat. No. 7,435,807


D-8
Maize
MON810
Insect resistance (Cry1Ab)
US 2004-180373


D-9
Maize
VIP1034
Insect resistance
WO 03/052073


D-10
Maize
B16
Glufosinate resistance
US 2003-126634


D-11
Maize
GA21
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-12
Maize
GG25
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-13
Maize
GJ11
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-14
Maize
FI117
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-15
Maize
GAT-ZM1
Glufosinate tolerance
WO 01/51654


D-16
Maize
DP-098140-6
Glyphosate tolerance/
WO 2008/112019





ALS inhibitor tolerance


D-17
Wheat
Event 1
Fusarium resistance
CA 2561992





(trichothecene 3-O-





acetyltransferase)


D-18
Sugar beet
T227-1
Glyphosate tolerance
US 2004-117870


D-19
Sugar beet
H7-1
Glyphosate tolerance
WO 2004-074492


D-20
Soybean
MON89788
Glyphosate tolerance
US 2006-282915


D-21
Soybean
A2704-12
Glufosinate tolerance
WO 2006/108674


D-22
Soybean
A5547-35
Glufosinate tolerance
WO 2006/108675


D-23
Soybean
DP-305423-1
High oleic acid/ALS
WO 2008/054747





inhibitor tolerance


D-24
Rice
GAT-OS2
Glufosinate tolerance
WO 01/83818


D-25
Rice
GAT-OS3
Glufosinate tolerance
US 2008-289060


D-26
Rice
PE-7
Insect resistance (Cry1Ac)
WO 2008/114282


D-27
Oilseed rape
MS-B2
Male sterility
WO 01/31042


D-28
Oilseed rape
MS-BN1/RF-BN1
Male sterility/restoration
WO 01/41558


D-29
Oilseed rape
RT73
Glyphosate resistance
WO 02/36831


D-30
Cotton
CE43-67B
Insect resistance (Cry1Ab)
WO 2006/128573


D-31
Cotton
CE46-02A
Insect resistance (Cry1Ab)
WO 2006/128572


D-32
Cotton
CE44-69D
Insect resistance (Cry1Ab)
WO 2006/128571


D-33
Cotton
1143-14A
Insect resistance (Cry1Ab)
WO 2006/128569


D-34
Cotton
1143-51B
Insect resistance (Cry1Ab)
WO 2006/128570


D-35
Cotton
T342-142
Insect resistance (Cry1Ab)
WO 2006/128568


D-36
Cotton
event3006-210-23
Insect resistance (Cry1Ac)
WO 2005/103266


D-37
Cotton
PV-GHGT07 (1445)
Glyphosate tolerance
US 2004-148666


D-38
Cotton
MON88913
Glyphosate tolerance
WO 2004/072235


D-39
Cotton
EE-GH3
Glyphosate tolerance
WO 2007/017186


D-40
Cotton
T304-40
Insect-resistance (Cry1Ab)
WO2008/122406


D-41
Cotton
Cot202
Insect resistance (VIP3)
US 2007-067868


D-42
Cotton
LLcotton25
Glufosinate resistance
WO 2007/017186


D-43
Cotton
EE-GH5
Insect resistance (Cry1Ab)
WO 2008/122406


D-44
Cotton
event 281-24-236
Insect resistance (Cry1F)
WO 2005/103266


D-45
Cotton
Cot102
Insect resistance (Vip3A)
US 2006-130175


D-46
Cotton
MON 15985
Insect resistance
US 2004-250317





(Cry1A/Cry2Ab)


D-47
Bentgrass
Asr-368
Glyphosate tolerance
US 2006-162007


D-48
Aubergine
EE-1
Insect resistance (Cry1Ac)
WO 2007/091277









In one embodiment, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with the active compound combinations of the invention.







TABLE E







Non-exhaustive list of transgenic events and traits and their trade names.
















Genetically modified
Additional


No.
Trade name
Plant
Company
properties
information





E-1
Roundup
Beta vulgaris
Monsanto
Glyphosate tolerance




Ready ®
(sugar beet)
Company


E-2
InVigor ®
Brassica napus
Bayer
Canola rape was genetically




(Argentine
CropScience
modified with the following




canola)

result:






Ø expression of a gene which






confers tolerance to the






herbicide glyfosinate-






ammonium;






Ø introduction of a novel






hybrid breeding system for






canola rape which is based on






genetically modified male-






sterility (MS) and fertility-






restorer (RF) lines;






Ø expression of a gene for






resistance to antibiotics


E-3
Liberty Link ®
Brassica napus
BayerCropScience
Phosphinothricin tolerance




(Argentine




canola)


E-4
Roundup
Brassica napus
Monsanto
Glyphosate tolerance



Ready ®
(Canola rape)
Company


E-5
Clearfield ®
(Canola rape)
BASF
Non-GMO, imazamox





Corporation
tolerance


E-6
Optimum TM
Glycine max L.
Pioneer Hi-Bred
Glyphosate and ALS herbicide



GAT TM
(soybean)
International,
tolerance





Inc


E-7
Roundup
Glycine max L.
Monsanto
Glyphosate tolerance



Ready TM
(soybean)
Company


E-8
Roundup
Glycine max L.
Monsanto
Glyphosate tolerance



RReady2Yiel TM
(soybean)
Company


E-9
STS ®
Glycine max L.
DuPont
Sulfonylurea tolerance




(soybean)


E-10
YIELD
Glycine max L.
Monsanto



GARD ®
(soybean)
Company


E-11
AFD ®
Gossypium
Bayer
The lines include, for




hirsutum
CropScience
example, AFD5062LL,




L. (cotton)

AFD5064F, AFD5065B2F;






AFD seed is available in a






wide range of varieties with






integrated technology such as,






for example, the Bollgard ®,






Bollgard II, Roundup Ready,






Roundup Ready Flex and






LibertyLink ® technologies


E-12
Bollgard II ®
Gossypium
Monsanto
MON 15985 event:




hirsutum
Company
Cry2(A)b1; Cry1A(c)




L. (cotton)


E-13
Bollgard ®
Gossypium
Monsanto
Cry 1Ac




hirsutum
Company




L. (cotton)


E-14
FiberMax ®
Gossypium
Bayer




hirsutum
CropScience




L. (cotton)


E-15
Liberty Link ®
Gossypium
Bayer
Phosphinothricin tolerance




hirsutum
CropScience




L. (cotton)


E-16
Nucotn 33B
Gossypium
Delta Pine and
Bt toxin in the lines from




hirsutum
Land
Delta Pine: Cry1Ac




L. (cotton)


E-17
Nucotn 35B
Gossypium
Delta Pine and
Bt toxin in the lines from




hirsutum
Land
Delta Pine: Cry1Ac




L. (cotton)


E-18
Nucotn ®
Gossypium
Delta Pine and
Bt toxin in the lines from




hirsutum
Land
Delta Pine




L. (cotton)


E-19
PhytoGeu TM
Gossypium
PhytoGen Seed
Comprises varieties which




hirsutum
Company, Dow
contain, for example, Roundup




L. (cotton)
AgroSciences
Ready flex, Widestrike





LLC


E-20
Roundup
Gossypium
Monsanto
Glyphosate tolerance



Ready Flex ®
hirsutum
Company




L. (cotton)


E-21
Roundup
Gossypium
Monsanto
Glyphosate tolerance



Ready ®
hirsutum
Company




L. (cotton)


E-22
Widesirike TM
Gossypium
Dow
Cry1F and Cry1Ac
Monsanto/Dow




hirsutum
AgroSciences




L. (cotton)
LLC


E-23
YIELD
Gossypium
Monsanto

http://www.garstseed.com/



GARD ®
hirsutum
Company

GarstClient/Technology/agrisure.aspx




L. (cotton)


E-24
Roundup
Medicago sativa
Monsanto
Glyphosate tolerance



Ready ®
(alfalfa)
Company


E-25
Clearfield ®
Oryza sativa
BASF
Non-GMO, imazamox




(rice)
Corporation
tolerance


E-26
NewLeaf ®
Solanum
Monsanto
Resistance to infection by




tuberosum
Company
potato leafroll virus (PLRV)




L. (potato)

and feeding damage by the






Colorado beetle Leptinotarsa






decemlineata


E-27
NewLeaf ®
Solanum
Monsanto
Resistance to infection by
http://www.dowagro.com/



plus
tuberosum
Company
potato leafroll virus (PLRV)
phytogen/index.htm




L. (potato)

and feeding damage by the






Colorado beetle Leptinotarsa






decemlineata


E-28
Protecta ®
Solanum




tuberosum




L. (potato)


E-29
Clearfield ®
Sunflower
BASF
Non-GMO, imazamox





Corporation
tolerance


E-30
Roundup
Triticum aestivum
Monsanto
Glyphosate tolerance, NK603



Ready ®
(wheat)
Company


E-31
Clearfield ®
Wheat
BASF
Non-GMO, imazamox





Corporation
tolerance


E-32
Agrisure ®
Zea mays
Syngenta Seeds,
These include Agrisure CB/LL



(family)
L. (maize)
Inc.
(BT 11 event plus






phosphinothricin tolerance as






the result of GA21 event);






Agrisure CB/LL/RW (Bt 11






event, modified synthetic






Cry3A gene, phosphinothricin






tolerance as the result of






GA21 event);






Agrisure GT (glyphosate






tolerance);






Agrisure GT/CB/LL






(glyphosate and






phosphinothricin tolerance as






the result of GA21 event, Bt






11 event);






Agrisure 3000GT






(CB/LL/RW/GT: glyphosate






and phosphinothricin tolerance






as the result of GA21 event, Bt






11 event, modified synthetic






Cry3A gene);






Agrisure GT/RW (glyphosate






tolerance, modified synthetic






Cry3A gene);






Agrisure RW (modified






synthetic Cry3A gene); future






traits


E-33
BiteGard ®
Zea mays
Novartis Seeds
cry1A(b) gene




L. (maize)


E-34
Bt-Xtra ®
Zea mays
DEKALB
cry1Ac gene




L. (maize)
Genetics





Corporation


E-35
Clearfield ®
Zea mays
BASF
Non-GMO, imazamox




L. (maize)
Corporation
tolerance


E-36
Herculex ®
Zea mays
Dow



(family)
L. (maize)
AgroSciences





LLC


E-37
IMI ®
Zea mays
DuPont
Imidazolinone tolerance




L. (maize)


E-38
KnockOut ®
Zea mays
Syngenta Seeds,
SYN-EV176-9: cry1A(b) gene




L. (maize)
Inc.


E-39
Mavera ®
Zea mays
Renessen LLC
High-lysine
http://www.dowagro.com/widestrike/




L. (maize)


E-40
NatureGard ®
Zea mays
Mycogen
cry1A(b) gene




L. (maize)


E-41
Roundup
Zea mays
Monsanto
Glyphosate tolerance
http://www.starlinkcorn.com/



Ready ®
L. (maize)
Company
starlinkcorn.htm


E-42
Roundup
Zea mays
Monsanto
Glyphosate tolerance



Ready ® 2
L. (maize)
Company


E-43
SmartStax
Zea mays
Monsanto
Combination of eight genes




L. (maize)
Company


E-44
StarLink ®
Zea mays
Aventis
Cry9c gene




L. (maize)
CropScience ->





Bayer





CropScience


E-45
STS ®
Zea mays
DuPont
Sulfonylurea tolerance




L. (maize)


E-46
YIELD
Zea mays
Monsanto
Mon810, Cry1Ab1, resistance
http://www.dowagro.com/herculex/



GARD ®
L. (maize)
Company
to the European corn borer
about/herculexfamily/


E-47
YieldGard ®
Zea mays
Monsanto
Mon810xMon863, dual



Plus
L. (maize)
Company
resistance to European corn






borer and corn rootworm


E-48
YieldGard ®
Zea mays
Monsanto
Mon863, Cry3Bb1, resistance



Rootworm
L. (maize)
Company
to corn rootworm


E-49
YieldGard ®
Zea mays
Monsanto
Stacked traits



VT
L. (maize)
Company


E-50
YieldMaker TM
Zea mays
DEKALB
Contains Roundup Ready 2




L. (maize)
Genetics
technology, YieldGard VT,





Corporation
YieldGard Corn Borer,






YieldGard Rootworm and






YieldGard Plus









In one embodiment, the plants comprising a transgenic event or expressing a trait of E-1 to E-50 of Table E, in total, or parts thereof, or propagation material of said plants are treated or contacted with the active compound combinations of the invention.
The plants listed can be treated in a particularly advantageous manner in accordance with the invention with the active compound combinations of the invention. The preferred ranges stated above for the active compound combinations also apply to the treatment of these plants. Particular emphasis is given to the treatment of plants with the active compound combinations specifically mentioned in the present text.
The active compound combinations can be converted to the customary formulations, such as solutions, emulsions, wettable powders, suspensions, powders, dusts, pastes, soluble powders, granules, suspension-emulsion concentrates, natural materials impregnated with active compound, synthetic materials impregnated with active compound and microencapsulations in polymeric substances.
These formulations are produced in a known manner, for example by mixing the active compound with extenders, that is liquid solvents and/or solid carriers, optionally with the use of surfactants, that is emulsifiers and/or dispersants and/or foam-formers.
Suitable for use as auxiliaries are substances which are suitable for imparting to the active compound combination itself and/or to preparations derived therefrom (for example spray liquors, seed dressings) particular properties such as certain technical properties and/or also particular biological properties. Typical suitable auxiliaries are: extenders, solvents and carriers.
Suitable extenders are, for example, water, polar and nonpolar organic chemical liquids, for example from the classes of the aromatic and non-aromatic hydrocarbons (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), the alcohols and polyols (which, if appropriate, may also be substituted, etherified and/or esterified), the ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly)ethers, the unsubstituted and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, the sulphones and sulphoxides (such as dimethyl sulphoxide).
If the extender used is water, it is also possible to employ, for example, organic solvents as auxiliary solvents. Essentially, suitable liquid solvents are: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, for example petroleum fractions, mineral and vegetable oils, alcohols such as butanol or glycol and also their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethylformamide and dimethyl sulphoxide, and also water.
Suitable solid carriers are:
for example, ammonium salts and ground natural minerals such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals, such as finely divided silica, alumina and silicates; suitable solid carriers for granules are: for example, crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, and also synthetic granules of inorganic and organic meals, and granules of organic material such as paper, sawdust, coconut shells, maize cobs and tobacco stalks; suitable emulsifiers and/or foam-formers are: for example, nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers, alkylsulphonates, alkyl sulphates, arylsulphonates and also protein hydrolyzates; suitable dispersants are nonionic and/or ionic substances, for example from the classes of the alcohol-POE- and/or -POP-ethers, acid and/or POP-POE esters, alkyl aryl and/or POP-POE ethers, fat- and/or POP-POE adducts, POE- and/or POP-polyol derivatives, POE- and/or POP-sorbitan- or -sugar adducts, alkyl or aryl sulphates, alkyl- or arylsulphonates and alkyl or aryl phosphates or the corresponding PO-ether adducts. Furthermore, suitable oligo- or polymers, for example those derived from vinylic monomers, from acrylic acid, from EO and/or PO alone or in combination with, for example, (poly)alcohols or (poly)amines. It is also possible to employ lignin and its sulphonic acid derivatives, unmodified and modified celluloses, aromatic and/or aliphatic sulphonic acids and their adducts with formaldehyde.
Tackifiers such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or latices, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, as well as natural phospholipids such as cephalins and lecithins, and synthetic phospholipids, can be used in the formulations. Further additives may be mineral and vegetable oils.
It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide and Prussian Blue, and organic dyestuffs, such as alizarin dyestuffs, azo dyestuffs and metal phthalocyanine dyestuffs, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.
The formulations generally comprise between 0.1 and 95% by weight of active compound, preferably between 0.5 and 90%, and in addition preferably extenders and/or surfactants.
The active compound content of the use forms prepared from the commercially available formulations can vary within wide limits. The active compound concentration of the use forms can be from 0.0000001 to 95% by weight of active compound, preferably between 0.0001 and 1% by weight.
Application is in a manner appropriate for the use forms.
The good insecticidal and/or acaricidal activity of the active compound combinations is illustrated by the examples below. Whereas the individual active compounds show weaknesses in their activity, the combinations show an activity which exceeds a simple addition of activities.
A synergistic effect in insecticides/acaricides is always present when the activity of the active compound combinations exceeds the total of the activities of the active compounds when applied individually. The expected activity for a given combination of two active compounds can be calculated according to S. R. Colby, Weeds 15 (1967), 20-22 as follows:
If

    X is the kill rate, expressed in % of the untreated control, when active compound A is applied at an application rate of m g/ha or at a concentration of m ppm,
    Y is the kill rate, expressed in % of the untreated control, when active compound B is applied at an application rate of n g/ha or at a concentration of n ppm and
    E is the kill rate, expressed in % of the untreated control, when active compounds A and B are applied at application rates of m and n g/ha or at a concentration of m and n ppm,

then







  E
  =
  
    X
    +
    Y
    -
    
      
        X
        ·
        Y
      
      100
    
  




If the actual insecticidal kill rate is greater than calculated, the kill of the combination is superadditive, i.e. there is a synergistic effect. In this case, the actual observed kill rate has to be greater than the value for the expected kill rate (E) calculated from the formula given above.
USE EXAMPLES
Example A
Aphis gossypii Test
To produce a suitable preparation of active compound, the desired formulation is mixed with water and the concentrate is diluted with water to the desired concentration.
Individually potted conventional or transgenic—comprising a gene coding for herbicide resistance—cotton plants heavily infested by the cotton aphid (Aphis gossypii) are treated by spraying with the active compound preparation of the desired concentration.
After the desired period of time, the kill in % is determined. 100% means that all aphids have been killed; 0% means that no aphids have been killed. The kill rates determined are entered into Colby's formula (see Sheet 1).
In this test, for example, the following active compound combination in accordance with the present application shows a synergistically enhanced activity compared to the active compounds applied individually:







TABLE A1







Aphis gossypii test










Concentration
Activity


Active compound/event
in g of ai/ha
in % after 3d












cotton comprising GHB614

0


Dyne-Amic
0.1%
0


spirotetramat SC 240
 75
0


on conventional cotton


spirotetramat SC 240 + 0.1%
75 + 0.1%
40


Dyne-Amic


on conventional cotton


Roundup Ultramax SL 450
1541
35 (PTX 45%)


(Glyphosate)


on conventional cotton












found*
calc.**









spirotetramat + glyphosate
75 + 1541
PTX


on conventional cotton


spirotetramat SC 240
 75
5


on cotton comprising GHB614


spirotetramat SC 240 + 0.1%
75 + 0.1%
20


Dyne-Amic


on cotton comprising GHB614


Roundup Ultramax SL 450
1541
0


(glyphosate)


on cotton comprising GHB614












found*
calc.**


spirotetramat + glyphosate on
75 + 1541
50
5


cotton comprising GHB614


according to the invention





*found = activity found


**calc. = activity calculated using Colby's formula


PTX = plant damage


Spirotetramat = A.2













TABLE A2







Aphis gossypii test










Concentration
Activity


Active compound/event
in g of ai/ha
in % after 4d












cotton comprising GHB614

0


spirotetramat SC 240
100
15


on conventional cotton


spirotetramat SC 240
100
0


on cotton comprising GHB614


Roundup Ultramax SL 450
1541
PTX


(glyphosate) on conventional


cotton


Roundup Ultramax SL 450
1541
25


(glyphosate) on cotton comprising


GHB614












found*
calc.**









spirotetramat + glyphosate
100 + 1541
PTX


on conventional cotton










spirotetramat + glyphosate
100 + 1541
65
25


on cotton comprising GHB614


according to the invention





*found = activity found


**calc. = activity calculated using Colby's formula













TABLE A3







Aphis gossypii test










Concentration
Activity


Active compound/event
in g of ai/ha
in % after 4d












cotton comprising T304-40 X

0


GHB119


spirotetramat SC 240
100
15


on conventional cotton


spirotetramat SC 240
100
0


on cotton comprising T304-40 X


GHB119


Ignite 280 SL (glufosinate-
125
PTX


ammonium)


on conventional cotton


Ignite 280 SL (glufosinate-
125
25


ammonium)


on cotton comprising T304-40 X


GHB119












found*
calc.**









spirotetramat + glufosinate-
100 + 125
PTX


ammonium


on conventional cotton










spirotetramat + glufosinate-
100 + 125
60
25


ammonium


on cotton comprising T304-40 X


GHB119


according to the invention





*found = activity found


**calc. = activity calculated using Colby's formula

## Claims

1. An active compound composition comprising compound (A) and one or more compounds of group (B)



and
(B),
glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-ammonium, glufosinate-P-sodium, glyphosate, and glyphosate-isopropylammonium,
wherein the active components consists of (A) and (B) and wherein the weight ratio of (A) to (B) is 1:100 to 100:1.

2. An active compound composition according to claim 1, further comprising at least one of the safeners: benoxacor, cloquintocet, cyprosulfamide, dichlormid, fenclorim, fenchlorazole furilazole, isoxadifen, mefenpyr, 4-(dichloroacetyl)-1-oxa-4-azaspiro[4.5]decane, and 2,2,5-trimethyl-3-(dichloroacetyl)-1,3-oxazolidine.

3. A method for controlling an agricultural pest comprising applying a composition as defined in claim 2 to a plant and/or to an above-ground part of a plant.

4. An agrochemical composition comprising an active compound composition according to claim 1, and one or more extenders and/or surfactants.

5. A method for controlling an agricultural pest, comprising allowing an active compound composition according to claim 1 to act on an agricultural pest, and/or a habitat thereof.

6. A process for preparing an agrochemical composition, comprising mixing an active compound composition according to claim 1 with one or more extenders and/or surfactants.

7. A method for controlling an agriculture pest comprising applying a composition as defined in claim 1, to a plant and/or to an above-ground part of a plant.

8. A method for improving production potential of a transgenic plant by controlling an agricultural pest comprising treating the transgenic plant with an effective amount of an active compound composition according to claim 1.

9. A method according to claim 8, wherein the transgenic plant is a soya bean plant and/or a cotton plant.

10. An article comprising an active compound composition according to claim 1 and at least one transgenic plant.

11. The active compound composition according to claim 1 wherein component (B) comprises glyphosate.

12. The active compound composition according to claim 1, comprising a synergistically effective amount of components (A) and (B).

13. The active compound composition according to claim 1, wherein (B) comprises glufosinate.

14. The active compound composition according to claim 1, wherein the active components consists of spirotetramat and one or more of glufosinate and glyphosate, and which comprises a synergistically effective amount of components (A) and (B), and wherein the weight ratio of (A) to (B) is 1:100 to 100:1.

15. A method for controlling an agricultural pest, comprising allowing (A) spirotetramat and (B) one or more compounds of glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-ammonium, glufosinate-P-sodium, glyphosate, and glyphosate-isopropylammonium to act on an agricultural pest, and/or a habitat thereo, wherein the active components consists of (A) and (B) and wherein the weight ratio of (A) to (B) is 1:100 to 100:1.

16. A method according to claim 15, wherein the compounds act on a transgenic, glyphosate- or glufosinate-herbicide-resistant cotton plant.

17. A method according to claim 15, wherein insects are controlled.