| 1. | I have reviewed this quarterly      report on Form 10-Q of Adeona Pharmaceuticals,  Inc.; |
|----|-------------------------------------------------------------------------------------------|

| 2. | Based on my knowledge, this      report does not contain any untrue statement of a material fact or omit to      state a material fact necessary to make the statements made, in light of      the circumstances under which such statements were made, not misleading      with respect to the period covered by this  report; |
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| 3. | Based on my knowledge, the      financial statements, and other financial information included in this      report, fairly present in all material respects the financial condition,      results of operations and cash flows of the registrant as of, and for, the      periods presented in thisreport; |
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| 4. | I am responsible for establishing      and maintaining disclosure controls and procedures (as defined in Exchange      Act Rules 13a-15(e) and 15d-15(e)) and internal control over      financial reporting (as defined in Exchange Act Rules 13a-15(f) and      15d-15(f), for the registrant and  have: |
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|  | a) | Designed such disclosure controls      and procedures, or caused such disclosure controls and procedures to be      designed under our supervision, to ensure that       material information relating to the registrant, including its      consolidated subsidiaries, is made known to us by others within those      entities, particularly during the period in which this report is being      prepared; |
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|   | b) | Designed such internal control      over financial reporting, or caused such internal control over financial      reporting to be designed under our supervision, to provide reasonable      assurance regarding the reliability of financial reporting and the      preparation of financial statements for external purposes in accordance      with generally accepted accounting  principles; |
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|   | c) |  Evaluated the effectiveness      of the registrant’s disclosure controls and procedures and presented in      this report our conclusions about the effectiveness of the disclosure      controls and procedures, as of the end of the period covered by this      report based on such evaluation;and |
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|   | d) | Disclosed in this report any      change in the registrant’s internal control over financial reporting that      occurred during the registrant’s most recent fiscal quarter (the      registrant’s fourth fiscal quarter in the case of an annual report) that      has materially affected, or is reasonably likely to materially affect, the      registrant’s internal control over financial reporting;      and |
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| 5. | I have disclosed, based on my      most recent evaluation of internal control over financial reporting, to      the registrant’s auditors and the audit committee of the registrant’s      board of directors (or persons performing the equivalent      functions): |
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|   | a) | All significant deficiencies and      material weaknesses in the design or operation of internal control over      financial reporting which are reasonably likely to adversely affect the      registrant’s ability to record, process, summarize and report financial      information; and |
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|   | b) |  Any      fraud, whether or not material, that involves management or other      employees who have a significant role in the registrant’s internal control      over financial reporting. |
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| Date:      November 15, 2010 | By:    | /s/ James S. Kuo, M.D.,      M.B.A.          |   |
|------------------------------|--------|---------------------------------------------------|--------|
|                         |   | Name:      James S. Kuo, M.D., M.B.A,             |   |
|                         |   | Title:      President and Chief Executive Officer |   |
|                         |   |  (Principal      Executive Officer)          |   |

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