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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549



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FORM 10-K



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|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended December 31, 2006

OR



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the Transition Period From              to

Commission file No. 000-30369



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MONOGRAM BIOSCIENCES, INC.

(Exact name of registrant as specified in its charter)



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|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|DELAWARE                                                       |  | 94-3234479                          
|(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer identification no.)
|                                                               | 
|345 Oyster Point Blvd South San Francisco, California          |  | 94080                               
|(Address of principal executive offices)                       |  | (Zip code)                          

Registrants Telephone Number, Including Area Code: (650) 635-1100



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Securities Registered Pursuant to
Section 12(b) of the Act:

Common Stock, $0.001 Par Value

(Title of class)

The NASDAQ Stock Market LLC

(Name of Each Exchange on Which Registered)

Securities Registered Pursuant to Section 12(g) of the Act:

None



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Indicate by check mark if the
registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.    Yes ̈No  x

Indicate by check mark if the registrant is not
required to file reports pursuant to Section 13 or Section 15(d) of the Act.    Yes ̈No  x

Indicate by check mark whether the Registrant
(1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and
(2) has been subject to such filing requirements for the past 90 days.    Yes  x    No ̈

Indicate by check mark if disclosure of delinquent filers pursuant to
Item 405 of Regulation S-K (Section 229.405 of this chapter) is not contained herein, and will not be contained, to the best of Registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of
this Form 10-K or any amendment to this Form 10-K.  x

Indicate by check mark whether the
registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of accelerated filer and large accelerated filer in Rule 12b-2 of the Exchange Act.



|                         |  |                      |  |                       
|------------------------ |  | -------------------- |  | ----------------------
|Large accelerated filer ̈ |  | Accelerated filer  x |  | Non-accelerated filer ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of
the Act).    Yes ̈No  x

The aggregate market value of the voting stock held by non-affiliates of the Registrant as of June 30, 2006 was $128,971,880.*

The number of shares outstanding of the Registrants Common Stock was 131,742,353 as of March 5, 2007.

DOCUMENTS INCORPORATED BY REFERENCE

The registrants Definitive Proxy Statement, to be filed with the Securities and Exchange Commission (the Commission) pursuant to Regulation 14A in connection with the 2007 Annual Meeting of Stockholders (the 2007
Annual Meeting), is incorporated by reference into Part III of this Report.

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|* | Excludes 65,460,649 shares of Common Stock held by directors, officers and stockholders whose beneficial ownership exceeds 5% of the Registrants Common Stock outstanding. The
number of shares owned by such persons was determined based upon information supplied by such persons and upon Schedules 13D and 13G, if any, filed with the SEC. Exclusion of shares held by any person should not be construed to indicate that such
person possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the Registrant, that such person is controlled by or under common control with the Registrant, or that such persons are affiliates for
any other purpose.
|- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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TABLE OF CONTENTS



|           |  |                                                                                                              |  |   
|---------- |  | ------------------------------------------------------------------------------------------------------------ |  | --
|PART I     |  |                                                                                                              |  |   
|Item 1.    |  | Business                                                                                                     |  | 3 
|Item 1A.   |  | Risk Factors                                                                                                 |  | 23
|Item 1B.   |  | Unresolved Staff Comments                                                                                    |  | 41
|Item 2.    |  | Properties                                                                                                   |  | 41
|Item 3.    |  | Legal Proceedings                                                                                            |  | 41
|Item 4.    |  | Submission of Matters to a Vote of Security Holders                                                          |  | 42
|           |  |                                                                                                             
|PART II    |  |                                                                                                              |  |   
|Item 5.    |  | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities |  | 43
|Item 6.    |  | Selected Financial Data                                                                                      |  | 44
|Item 7.    |  | Managements Discussion and Analysis of Financial Condition and Results of Operations                        |  | 46
|Item 7A.   |  | Quantitative and Qualitative Disclosures About Market Risk                                                   |  | 62
|Item 8.    |  | Financial Statements and Supplementary Data                                                                  |  | 63
|Item 9.    |  | Changes in and Disagreements with Accountants on Accounting and Financial Disclosure                         |  | 97
|Item 9A.   |  | Controls and Procedures                                                                                      |  | 97
|Item 9B.   |  | Other Information                                                                                            |  | 97
|           |  |                                                                                                             
|PART III   |  |                                                                                                              |  |   
|Item 10.   |  | Directors, Executive Officers and Corporate Governance                                                       |  | 98
|Item 11.   |  | Executive Compensation                                                                                       |  | 98
|Item 12.   |  | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters               |  | 98
|Item 13.   |  | Certain Relationships and Related Transactions, and Director Independence                                    |  | 98
|Item 14.   |  | Principal Accounting Fees and Services                                                                       |  | 98
|           |  |                                                                                                             
|PART IV    |  |                                                                                                              |  |   
|Item 15.   |  | Exhibits, Financial Statement Schedules                                                                      |  | 99
|Signatures |  | 104                                                                                                         



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This Annual Report on Form 10-K contains certain forward-looking statements within the meaning of the
safe harbor provisions of the Private Securities Litigation Reform Act of 1995 including, without limitation, statements regarding development and commercialization of our proposed products and services, and the possible growth of our
business into new markets. These statements, which sometimes include words such as expect, goal, may, anticipate, should, continue, or will, reflect our expectations
and assumptions as of the date of this Annual Report based on currently available operating, financial and competitive information. Actual results could differ materially from those in the forward-looking statements as a result of a number of
factors, including our ability to successfully complete the development and clinical validation of eTag assays and commercialize these assays for guiding treatment of cancer patients, the potential role of our assays in the development and use of
new classes of HIV drugs such as CCR5 inhibitors, the market acceptance of our products, the effectiveness of competitive products, new products and technological approaches, the risks associated with our dependence on patents and proprietary
rights, the possible infringement of the intellectual property rights of others, and our ability to raise additional capital if needed. These factors and others are more fully described in Risk Factors and elsewhere in this Form 10-K. We
assume no obligation to update any forward-looking statements.

PART I

Item 1.Business

Overview

We are a life sciences company committed to advancing personalized medicine and improving
patient outcomes through the development of innovative molecular diagnostic products that guide and target the most appropriate treatments. Through a comprehensive understanding of the genetics, biology and pathology of particular diseases, we have
pioneered and are developing molecular diagnostics and laboratory services that are designed to:



| |  |  | enable physicians to better manage infectious diseases and cancers by providing the critical information that helps them prescribe personalized treatments for
patients by matching the underlying molecular features of an individual patients disease to the drug expected to have maximal therapeutic benefit; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | enable pharmaceutical companies to develop new and improved anti-viral therapeutics and targeted cancer therapeutics more efficiently and cost effectively by
providing enhanced patient selection and monitoring capabilities throughout the development process.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We are a leader in
developing and commercializing innovative products that help guide and improve the treatment of infectious diseases, cancer and other serious diseases. Our goal with personalized medicine is to enable the management of diseases at the individual
patient level through the use of sophisticated diagnostics that permit the targeting of therapeutics to those patients most likely to respond to or benefit from them, thereby offering the right treatment to the right patient atthe
right time.

Monograms PhenoSenseand GeneSeq products provide a practical method for measuring the
impact of genetic mutations on human immunodeficiency virus, or HIV, drug resistance. This information is used to optimize various treatment options for the individual patient. We currently market phenotypic and genotypic resistance testing products
directed at patients with HIV infection and the drug classes currently approved for use. In addition, we have resistance tests in development or already used in research that are relevant to new drug classes, such as the integrase, entry and
assembly classes. In addition to these resistance tests, our Trofile Co-Receptor Tropism Assay has been used for patient selection in the phase III trials of the new class
of CCR5 antagonists. The first of these, maraviroc from Pfizer Inc. (Pfizer), is currently the subject of an NDA that has been accepted for priority review by the FDA. We expect that the Trofile Assay may be used for patient selection after
regulatory approval of maraviroc and other CCR5 antagonists.



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Over the last several years, we have built a business based on the personalized medicine approach in HIV
drug resistance testing and in patient screening. We now seek to leverage the experience and infrastructure we have built in the HIV market to the potentially larger market opportunity of cancer utilizing our proprietary eTag technology. In the future, we plan to seek
opportunities to address an even broader range of serious diseases.

New targeted drug therapies are being introduced for the treatment of
cancer. Our proprietary eTag technology provides an assay platform for analyzing very small amounts of tumor samples recovered and prepared in a variety of methods, including formalin fixation, the current standard technique in hospital
pathology laboratories. We believe this analytical platform may be well suited for the next generation of targeted cancer therapeutics. We believe that, upon completion of development, our eTag assays may permit the prediction, with a high
degree of accuracy, of the likelihood of a patients cancer responding to a given therapy, facilitating the selection of more precise and effective therapeutic options. We are developing Epidermal Growth Factor Receptor, or EGFR/HER,
eTag assays that we believe will enable physicians to identify the appropriate course of treatment for cancers that have a particular molecular profile. Our current focus is on drugs that target the EGFR/HER receptor family, initially in
breast cancer but subsequently in lung and other cancers. We intend to develop eTag assays that target other protein drug targets and signaling pathways that are key drivers of proliferation or survival in cancer cells.

We were incorporated in the state of Delaware in November 1995 and commenced commercial operations in 1999. Our principal executive offices are located
at 345 Oyster Point Blvd., South San Francisco, CA 94080. Further information can be found on our website: www.monogrambio.com. Information found on our website is not incorporated by reference into this report.

Background

Personalized Medicine

There is growing evidence that while many serious diseases, such as HIV and cancer, can be characterized at the molecular level, many drugs simply do not
work optimally for an entire population of patients in these broad disease categories. The biopharmaceutical industry is witnessing two mutually dependent innovations:



| |  |  | targeted therapies that act on very specific disease mechanisms that may not be present in all patients with a broadly defined disease; and
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | molecular diagnostic tests that may be able to predict in advance if a patient is likely to respond to a certain drug.
| | - |  | ----------------------------------------------------------------------------------------------------------------------

Based on these innovations, a new approach to disease management is emergingPersonalized Medicinein which effective treatment options
for the individual patient can be identified using specific diagnostic tests. The ideal of personalized medicine is to move from the so-called one size fits all method of drug treatment, to providing the right treatment to the
right patient at the right time.

Infectious Diseases

Viruses are microorganisms that must infect living cells to reproduce or replicate. These viruses infect human cells and replicate, making new viruses that can infect other cells. There are many different types of
viruses, but all viruses share structural and functional characteristics associated with their ability to replicate. During the replication cycle, all types of virus often change slightly, or mutate. This is particularly true of viruses such as HIV
and hepatitis C virus, or HCV. For example, in an untreated HIV-infected patient, HIV generates virus variants with genetic mutations at every possible nucleotide position, causing billions of new viruses to be produced each day. At any given time
there can be many different variants of the virus present within the infected patients body, each with a slightly different genetic sequence. This large number of virus variants allows HIV to adapt very rapidly and develop resistance to drugs.
As a consequence of drug resistance, HIV continues to cause a large number of infections and deaths despite the availability and introduction of new and effective treatments.



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Viral drug resistance refers to a reduction in the ability of a particular drug or combination of drugs
to block replication of the virus. Drug resistance typically occurs as a result of mutations that accumulate in the viral genome as it replicates. As the virus replicates and creates a multitude of mutations, the drug resistant mutations become more
prominent. For people infected with HIV, drug resistance can render drugs less effective or even completely ineffective, thus significantly reducing treatment options. The emergence and spread of strains of virus with drug resistance means that the
ability to treat infections and save lives has become increasingly difficult.

There are approximately 40,000 new diagnoses of HIV
infection in the United States each year. In time most of these progress to AIDS, which is one of the leading causes of death worldwide. It is estimated that approximately one million individuals in the United States are currently living with this
disease. While once considered a fatal disease, with the advent of 20 FDA-approved anti-viral drugs for treatment of HIV and over 60 more in development, HIV infection increasingly can be treated as a chronic disease.

The Viral Drug Resistance Crisis

While more
effective combination treatment regimens have been introduced for HIV, e.g. HAART (highly active antiretroviral therapy), over time the virus often develops resistance to the administered drugs, requiring a change in the combination of anti-viral
agents prescribed. Selecting the right combination of drugs for optimal treatment of HIV patients is often difficult when physicians have limited information about the susceptibility of the patients HIV to specific anti-viral drugs. Each
treatment failure increases the risk that the next drug combination will not work or work for a shorter period of time leaving the patient with fewer effective future treatment options. Physicians are faced with the challenge of tailoring therapy to
individual patients numerous times over the course of the disease.

Resistance to anti-viral drugs is one of the most serious impediments
to successful treatment of HIV/AIDS patients. In response to the problem of anti-viral drug resistance, physicians use combinations, or cocktails, of anti-viral drugs, attacking different targets within the virus simultaneously. However, even
combination therapy eventually fails in a great majority of patients, due in large part to the fact that the virus becomes resistant to some or all of the drugs used in combination.

Anti-viral drugs approved by the U.S. Food and Drug Administration, or FDA, are generally used in various combinations to treat HIV infected patients.
Combination therapy requires each drug in the combination to be active, interfering with key viral functions, for the therapy to be most effective. If any of the drugs are not active, the combination therapy will likely fail more quickly. Each
treatment failure leaves the patient with fewer future treatment options. Drug resistant viruses can also be transmitted to newly infected individuals, increasing the risk that initial treatment for those individuals will not work.

There are 20 FDA-approved drugs currently marketed for treatment of HIV. These generally fall into four classes of drug. These are nucleoside reverse
transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors and entry inhibitors. Most currently approved HIV therapeutics are in the first three classes. There is one approved entry inhibitor, although many are in
development including those targeting the use by HIV of the CCR5 co-receptor, which are the most advanced entry inhibitors in clinical trials. The first CCR5 antagonist, maraviroc from Pfizer, is currently the subject of an NDA that has been
accepted for priority review by the FDA. Two drugs in the integrase class are in advanced clinical evaluation. Other drugs in the CCR5, integrase and assembly classes are in earlier stages of development. These new drug classes may be expected to
add to the richness of available therapeutic choices for physicians and patients, but they also add to the complexity of the choices which may increase the need for sophisticated techniques for choosing among those potential therapies.

While new anti-viral drugs which may have increased potency and activity against drug resistant viruses are under development, the ability of HIV to
mutate and replicate continues to challenge physicians, who are faced



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with the challenge of identifying the most appropriate therapy for the individual patient. We believe that this ability of HIV to continually mutate, coupled
with the increased complexity of available therapy choices, will increase the need for sophisticated testing to identify resistance profiles.

Viral
Resistance Testing

In response to the challenge posed by drug resistant viruses and the complexity provided by multiple choices of
therapeutic, tests have been developed to assess the resistance of viruses to particular drugs. Simple tests based on an analysis of the genetic composition of the virus are now quite common. In addition, more sophisticated tests focused on more
direct, or phenotypic, measurement of drug resistance are also available. The technologies available for resistance testing are:



| |  |  | Phenotypic Assaysbased on direct measurements of anti-viral susceptibility in cell culture assays in the presence of all commercially available drugs, and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Genotypic Assaysbased on scanning the viral genome to identify known mutations associated with resistance to particular drugs.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------

Both types of test may improve treatment response and can be used either to realign existing therapy or to help selection of the best initial therapy
for a patient. Resistance testing has emerged as the standard of care in the management of patients with HIV. Current treatment guidelines from the U.S. Department of Health and Human Services, the International AIDS Society-USA and the
EuroGuidelines Group recommend resistance testing to identify new potent drug combinations after therapy failure. Phenotypic testing provides the most direct measure of drug resistance and, when combined with genotypic testing, provides the most
comprehensive view of a patients situation. The ultimate goal of resistance testing is to optimize therapies for the individual patient. Increasingly, the complexity of the virus, the sophistication of available testing, and the cost to the
patient both in terms of lost future treatment options as well as funds spent on expensive but ineffective therapies, make it more and more critical that physicians have access to as much information as possible when they determine therapy for their
patients.

Tropism and Patient Selection

Resistance testing is used at the time of therapy failure to determine which specific elements in a patients treatment regimen are failing and which drugs might be added to the regimen prospectively. A new type of testing has emerged
that can be used prior to therapy prescription to determine in advance whether specific patients are suitable for a particular drug. This form of testing assesses the tropism of the patient. Tropism refers to the particular
co-receptorCCR5 or CXCR4that the patients virus uses to infect host cells. Such testing may also have a role during therapy or after therapy failure for patient monitoring.

HIV utilizes one of two co-receptors to enter a patients host cells. These co-receptors are known as CCR5 and CXCR4. Each infected patient has HIV
that uses one or the other of these two co-receptors or that uses both co-receptors simultaneously. Collectively, where both co-receptors are used, such patients are known as dual/mixed.

One of the new classes of HIV drug in development is the class of CCR5 antagonists. Drugs in this class are designed to inhibit the use of the CCR5
co-receptor, and thereby prevent entry by HIV into host cells. However, for such drugs to be effective, it is necessary for the patients virus to use the CCR5 co-receptor. Efficacy is not expected where the patients HIV uses CXCR4 or is
dual/mixed. Accordingly, efficacy of CCR5 antagonist drugs requires an effective test that identifies the tropism of the patient, or whether the CCR5 co-receptor target of the drug is present, or not. Monograms Trofile Co-Receptor Tropism
Assay is such a test and has been used in all phase II and phase III trials to date for CCR5 antagonists.



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Oncology

Over one million new cases of solid tumor cancer are diagnosed each year in the United States, with three cancer types (breast, lung and colorectal) accounting for over 500,000 of these. While the incidence of lung cancer is declining
slightly, the incidence of breast and colorectal cancer is believed to be increasing at approximately five percent annually.

Although
there are often several therapeutic options for a given indication, treatment is typically expensive and accompanied by a host of adverse side effects that are detrimental to patients quality of life. In many cases, treatments are effective in
only a small percentage of the total patient population and so multiple treatment options must be pursued sequentially until an effective one is found. Often, relatively non-specific broader acting cancer therapeutic agents, including various
chemotherapies and radiotherapy are used as first-line and second-line therapies before more specific, targeted therapeutics are used. These broader agents often have serious debilitating side effects associated with them. Typically, not until a
patient has failed these treatments either because of intolerable or adverse side effects or because their cancer does not respond or has progressed are newer targeted therapies tried. These targeted therapies are often used in
third-line treatment because the percentage of patients in the overall population for whom they are effective is relatively low (10%-20%). For patients with a life threatening disease, the sequential approach to the selection of therapies is not
optimal but is a consequence of the limited information available to physicians. Despite many years of clinical studies, physicians still have inadequate information on which to base many treatment decisions and many newer targeted drugs have low
levels of response in the general disease population, even though in a subset of the patient population they can be extremely effective. The consequences of suboptimal or inappropriate therapies include poor patient outcomes, both from side effects
and lack of activity, as well as an economic burden on the healthcare systemthe added costs of the physicians time, wasted drugs and increased hospitalization.

Patient Selection Testing

There is growing acknowledgement that the current methods of classifying
different types of cancer by the tissue of origin (e.g. breast cancer or lung cancer) are relatively imprecise, and that better methods of categorizing an individuals cancer or tumor may be possible. In fact, it is now believed that individual
tumors of different types (e.g. lung cancer and breast cancer) from different patients may be more closely related at the molecular level, and more likely to respond to a particular targeted therapy, than two lung tumors or two breast tumors.
Separate lung cancer tissues may appear to be the same, but at the molecular level they may display very different biological processes. For a treatment to be optimally effective in killing or controlling cancer cells in an individual patient, it is
desirable to have diagnostic tests that are able to see at this level and to determine what is driving the growth of the cancer cells in that individual patient and which drug will affect that particular process.

Cancer cells proliferate through the activation and interaction of complex biological pathways, stimulated by both extracellular signals and
intracellular changes. In order to cure a patients cancer, or to control it and limit its progression, physicians must have an understanding of these complex processes, and which particular pathways have been activated and are driving cancer
cell growth in each particular patient. New molecular methods and analytical techniques are attempting to provide this information. These new technologies hold the potential for revolutionizing cancer diagnosis and treatment, enabling physicians to
make decisions on what treatment options are best suited for an individual patient.

Recently there has been scientific debate about the
predictive nature of particular genetic markers or genomic structures, such as the identification of specific gene mutations or gene expression levels present in the tumor tissue of certain patients. While this information is extremely useful in
some cases, the biological patterns that result in uncontrolled cell growth and cancer are much more complex, and are influenced by many additional factors, than can be communicated in simple gene mutations. Often, while statistical relationships
are postulated between such genetic markers and clinical outcome, there may be no well understood biological rationale for the statistical relationship. We believe that a more comprehensive understanding of the biology involved in cancer



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cell growth and drug response, especially at the level of proteins, protein complexes and signaling pathways, where most drugs work, is required to enable
physicians to select the right therapy. In our view, effective diagnostic tests are those that can identify the presence of the proteins and protein complexes that are the targets of the drugs in question. Even greater predictive power would likely
accrue to those diagnostic tests able to measure the targets in their activated state, those target proteins actively involved in the disease process or mechanism attacked by the drug.

There are many cellular pathways which, when activated, cause proliferation of cancer cells. One of these, on which substantial drug development activity
has been targeted, is the EGFR/HER pathway. The four receptors in the EGFR/HER familyHER1, HER2, HER3 and HER4are present on the surface of many cells and when activated can combine with other HER family receptors to form a protein
dimer. These dimers initiate pathways that can cause proliferation of cancer cells. Four drugs approved by the FDA target various elements of this family of pathways. These are Herceptin®, Iressa®, Tarceva®, Erbitux®, although Iressa has had restrictions placed on its use Many more drugs targeting this pathway are in development. The protein complexes targeted by these drugs are not present in all
patients and when present, are present in different proportions. Accordingly, the ability to detect and quantify the presence of the relevant activated drug targets is important to understanding whether particular drugs are likely to be effective.
Simple analysis of whether certain proteins are present is not sufficient without the additional information as to their activation status.

Monograms Solution

Our solution to these challenges is based on molecular diagnostic tools that are designed to aid
drug development and guide patient therapy by:



| |  |  | enabling physicians to better manage infectious diseases and cancers by providing the critical information that helps them prescribe personalized treatments for
patients by matching the underlying molecular features of an individual patients disease to the drug expected to have maximal therapeutic benefit; and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | enabling pharmaceutical companies to develop new and improved anti-viral therapeutics and targeted cancer therapeutics more efficiently and cost effectively by
providing enhanced patient selection and monitoring capabilities throughout the development process.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Infectious Diseases

Our proprietary technology identifies drug resistance in viruses that cause serious infectious diseases and can also identify a
patients tropism to screen for likely drug response to certain drugs. Our products are used primarily in the management of patients with HIV/AIDS. We make our tests available both to physicians to guide the management of patients
treatment and to pharmaceutical companies to aid in the development and clinical evaluation of new drugs.



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The following table sets out the products that are offered to physicians in guiding the selection of
therapy from among approved drugs and the tests available to pharmaceutical and biotechnology companies for use in drug development and clinical trial patient recruitment:

Products for HIV Testing



|                                       |  |                                                                                                                                                                                       |  |                 |                          |   |  |   | 
|-------------------------------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | --------------- | ------------------------ | - |  | - | 
|Product                                |  | Description                                                                                                                                                                           |  | Target Customer
|                                       |  | Physicians                                                                                                                                                                            |  |                 | Pharmaceutical Companies
|                                       |  |                                                                                                                                                                                       | 
|PhenoSense HIV                         |  | Directly and quantitatively measures resistance of a patients HIV to anti-viral drugs                                                                                                |  | ü               |                          |   |  | ü | 
|GeneSeq HIV                            |  | Examines and evaluates the genetic sequences of a patients HIV                                                                                                                       |  | ü               |                          |   |  | ü | 
|PhenoSense GT                          |  | Combination product of the PhenoSense HIV and GeneSeq HIV tests integrated into one report                                                                                            |  | ü               |                          |   |  | ü | 
|Replication Capacity HIV (1)           |  | Measures viral fitness, or the ability of a virus to reproduce and infect new cells                                                                                                   |  | ü               |                          |   |  | ü | 
|PhenoSense HIV Entry                   |  | Directly and quantitatively measures resistance of a patients HIV to entry inhibitors                                                                                                |  | ü               |                          |   |  | ü | 
|GeneSeq HIV Entry                      |  | Examines and evaluates the genetic sequences of a patients HIV for evidence of resistance to entry inhibitors                                                                        |  |                 |                          |   |  | ü | 
|Trofile Co-Receptor Tropism            |  | Identifies the co-receptor the patients virus uses to enter cells, or tropism; a patient screening assay that may also be a prognostic
factor in the pace of HIV disease progression |  |                 | (2                       | ) |  | ü | 
|PhenoSense and GeneSeq HIV Integrase   |  | Measures HIV resistance to integrase inhibitors for use in research and drug development                                                                                              |  |                 | (3                       | ) |  | ü | 
|PhenoSense HIV Antibody Neutralization |  | Tests patients blood samples for the presence of antibodies that neutralize the HIV virus preventing the virus
from infecting other cells (used in vaccine development programs)     |  |                 |                          |   |  | ü | 
|PhenoScreen                            |  | High-throughput screening for the identification of potential clinical drug candidates                                                                                                |  |                 |                          |   |  | ü | 

---

|(1) | The Replication Capacity HIV test data is provided with the PhenoSense HIV and PhenoSense GT test data.
|--- | -------------------------------------------------------------------------------------------------------

|(2) | The Trofile Co-Receptor Tropism assay is Clinical Laboratory Improvement Amendments of 1988, or CLIA, approved and could be made available to physicians but is not currently made
available as there are no relevant drugs approved for commercial use. One such drug, maraviroc from Pfizer, is currently receiving accelerated review by both the FDA and European regulatory authorities. The Trofile assay will be made
available to physicians in parallel with the approval of maraviroc for commercial use.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Assays for the integrase class are being validated and are expected to be available for physician use as needed after the first integrase drug is approved by the FDA.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------

In addition to the HIV testing products detailed above, we have PhenoSense HCV and GeneSeq HCV assays, some of which are
still in development while others are made available to pharmaceutical companies for use in their drug discovery and development programs.

The products that are currently used in pharmaceutical company testing may represent potential future new products for the patient testing aspect of our business as clinical utility is established and as additional drugs are commercialized.



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Physicians

Utilizing the information from the various products that we have developed, physicians are able to manage the treatment of HIV and prescribe personalized treatments for patients.

Our GeneSeq test determines the genetic sequence of HIV and provides physicians with a prediction of expected drug resistance based on the particular
mutations present in the individual patients virus. Our PhenoSense technology, rather than relying on known genotypic associations to make predictions of drug resistance, provides a direct measurement of the activity of each of the currently
available anti-retroviral drugs against the patients individual virus. By directly measuring the interaction of drug with viral enzyme, it avoids the need to rely on predictions when knowledge of genotypic resistance is lacking. The direct and
quantitative nature of the phenotypic information that is provided facilitates a more useful characterization of the continuum of resistance than can be derived from basic genotypic tests. In addition, our tests can be automated and performed in
large numbers, making them practical for routine use in the clinical management of patients. Currently marketed tests address the existing classes of approved drugs. Assays for the integrase class are expected to be available at the time of
commercial availability of the drugs.

Our Trofile Co-Receptor Tropism Assay identifies the co-receptor that the patients HIV uses to
enter the cell. For the new class of CCR5 inhibitor drugs, it is important to know which co-receptor is being accessed by the virus for entry into cells. This test has been used to select patients for clinical trials of CCR5 antagonists in
development, including maraviroc, Pfizers CCR5 antagonist that is currently receiving accelerated review by both the FDA and European regulatory authorities. Once maraviroc is approved, the Trofile Assay may be used to aid
physicians in prescribing the drugs.

We believe the information generated by our technology supports and guides the decision making
process for physicians to identify optimal therapeutic treatment regimens for each patient. Through our genotypic and phenotypic tests, we provide a comprehensive report to the physician outlining the likely response of the patients disease to
all 20 approved HIV drugs. To provide more cost effective and timely data to the physician, we utilize an online test reporting system for our comprehensive portfolio of HIV drug resistance assays, PhenoSense GT, PhenoSense HIV and GeneSeq HIV and
for our Trofile Co-Receptor Tropism Assay. Our secure online system facilitates data analysis, allowing examination of historical patient resistance data to help identify resistance patterns in patients over time, and it helps decrease the time
between sample submission and reporting the results of the assays to physicians.

Pharmaceutical Companies

Pharmaceutical companies are under significant pressure to increase the productivity of their research and development functions. Significant impact on
revenue for a pharmaceutical company can be derived from accelerating the progress of existing drugs in development through clinical trials, as well as by enhancing drug discovery programs.

Increasing the speed and probability of success of clinical trials and accelerating the commercialization of drug candidates can be achieved through the
advent of tests that are based on a personalized medicine approach. By identifying patients utilizing biomarkers that are predictive of response to the drug under investigation, we believe clinical trials can be shorter, smaller and less costly, and
have a higher probability of successful completion. In addition, the drug can be prescribed with a higher degree of expected effectiveness, be brought to market more rapidly, and potentially be positioned as a first- or second-line treatment rather
than a second- or third-line treatment.

Our products can be utilized by drug developers to:



| |  |  | Predict novel compounds potential benefits based on activity against a wide range of actual patient viruses and specific mutational patterns compared with
other drugs in the same class, and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Prioritize and optimize drug candidates based on identification of compounds with the best resistance profiles, allowing companies to invest resources in the most
promising drug candidates.
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Clinical trials are the most expensive part of drug development and pharmaceutical companies are now
utilizing the information from pharmacogenomics, the scientific discipline focused on how genetic differences among patients determine or predict responsiveness or adverse reactions to particular drugs, to improve the outcomes of clinical trials. In
a similar way, pharmaceutical companies are applying our PhenoSense technology to help select and monitor suitable patients for clinical trials and optimize background therapy prior to treatment with the investigational compound. This selection
process may allow pharmaceutical companies to guide important drug development decisions before large resource commitments are made. To date, we have provided testing services to almost all the pharmaceutical companies with drugs in development for
treatment of HIV/AIDS and our tests have been used in the testing of patient samples for every drug approved for treatment of HIV in the past five years. Importantly, the FDA has endorsed and emphasized the importance of resistance testing in drug
development.

Oncology

Utilizing our
eTag technology, we plan to expand our franchise into oncology. We aim to leverage our commercial experience to develop molecular diagnostic tests that will differentiate those patients who are likely to respond to new targeted therapies from
those patients who are not likely to respond. We are currently completing the development of our proprietary eTag assays that measure specific activated proteins and protein complexes and utilize tumor samples obtained from a patients
biopsy, to aid in prescribing the new targeted cancer drugs for these patients.

Our eTag assays require only a very small amount of
biological sample and are designed to be performed directly on fresh, frozen and the standard clinical formatformalin-fixed paraffin-embedded clinically derived patient samples. This ability to utilize small amounts of human clinical samples
in a wide range of formats, without extensive and time-consuming sample preparation, makes eTag assays well suited to diagnostic applications in human disease management.

Importantly, eTag assays can detect proteins, protein complexes, protein dimers and modified forms of these analytes, that are not readily
discernible with other technologies, especially in formalin-fixed human clinical samples. These analytes are expected to provide valuable information with respect to the activation states of key signaling pathways that drive cell proliferation and
survival in tumors, and serve as biomarkers that indicate the likelihood of response to particular targeted therapeutics in individual patients and specific patient sub-groups.

There are many signaling pathways involved in the proliferation of cancer cells in the body. One prominent one, on which substantial drug development
activity has been focused, is the Epidermal Growth Factor Receptor, or EGFR/Her pathway, within which there are four receptors known as Her1 or EGFR, Her2, Her3 and Her4. We are developing a portfolio of assays for the EGFR/Her pathway that will
ultimately include assays that measure the levels of individual receptor monomers such as Her1, Her2 and Her3; assays for the receptor homo-dimers such as Her1:1, and Her2:2; assays for the numerous hetero-dimers such as Her1:2, Her2:3, etc. and
assays for various modified forms of these receptors including p95/Her2. In time, we plan to have a broad portfolio of assays that provide comprehensive information for drugs targeting individual protein components of the EGFR/Her pathway so that
physicians will be able to detect resistance early and make better choices for their patients.

Our initial focus has been breast cancer
where Herceptin is already approved, lapatinib is expected to be approved shortly, and other drugs are in development. In breast cancer, there may be two opportunities based on evolving treatment settings for Herceptin. One is the opportunity for a
better test to support the design of treatment regimens, for advanced disease, that utilize Herceptin, chemotherapy and potentially other agents. A second and potentially larger opportunity may be for an improved test (in relation to existing tests)
to support the design of treatment regimens in patients with early stage disease, again looking at likely efficacy of targeted agents like Herceptin and chemotherapeutics.

Additional applications for EGFR/Her assays may exist in lung cancer, where current approaches to the selection of patients who are likely to respond to
targeted therapies are even more uncertain than in breast cancer,



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and we believe that the accurate assessment of activated drug targets in individual patients using the eTag assay has the potential to address this
need. Other opportunities include colorectal cancer and other malignancies in which EGFR/Her signaling may be driving or contributing to tumor growth.

The details and timing of our initial products are still dependent on the nature and timing of clinical data that is being generated in our clinical studies.

Physicians

We are completing the development of the
first EGFR/Her assays and their transfer into our CLIA certified clinical laboratory so that, after validation in accordance with CLIA standards, and after establishing the clinical utility of the assays through clinical studies, commercial tests
can be launched.

Pharmaceutical Companies

Several cancer drugs that target the EGFR/HER pathway have been approved for marketing (Herceptin, Iressa, Tarceva, Erbitux) with many more in development. As pharmaceutical companies continue to develop these targeted cancer therapies,
there is an urgent need to be able to distinguish those patients who are likely to respond to these treatments from those who will not.

We
intend to make our eTag assays available to pharmaceutical and biotechnology companies under collaborative agreements through which they can access our proprietary assay systems and development expertise for use in clinical development
programs. These assays and services can be a critical aide in patient selection in clinical trials of targeted therapies that may be highly efficacious in selected patient populations while only minimally effective in the general patient population.

On-Going Clinical Studies

Retrospective clinical studies are being conducted to further evaluate and confirm the clinical utility of our assays. In these studies, we are accessing previously collected tumor samples, performing our eTag assays on those samples
and comparing the results and predictions obtained from our assays with the known clinical outcomes. A number of studies are in progress and planned to generate this information. These studies involve a number of leading cancer centers, which will
provide tissue samples and collaborate with us to correlate the identified markers with clinical outcomes.

We are currently seeking
clinical validation of our first assays in breast cancer patient samples. The other assays that will support a comprehensive range of assays are expected to follow. We have performed the eTag assay on Formalin-fixed Paraffin-Embedded, or
FFPE, specimens from two clinical cohorts of breast cancer patients. We have observed consistent relationships between EGFR/Her family receptor interactions and clinical outcomes. We are actively working to obtain access to additional patient
samples to evaluate these correlations in independent cohorts of both early and late stage breast cancer patients. These studies, if successful, will provide the basis for a commercial product.

Monograms Strategy

Our objective is to be a
world leader in developing and commercializing innovative products to help guide and improve the treatment of infectious diseases, cancer and other serious diseases. We have focused on developing products that meet the treatment needs for infectious
diseases, primarily HIV/AIDS and believe that we have built the leading franchise in this area. We now seek to expand into the area of cancer therapy and in the future will seek opportunities to address an even broader range of serious diseases.



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Our strategy for addressing these objectives is two-fold: to support drug development and guide patient
therapy. Specifically, key elements of our strategy are to:



| |  |  | Leverage the Increasing Trend Towards Personalized Medicine. Our innovative technologies are developed to facilitate guiding treatment regimens for specific
patients. There is a growing need for technologies that identify those particular patients so that the drugs can be prescribed for the appropriate patient groups allowing for a personalized approach to therapy, by getting the right treatment to the
right patient at the right time.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Maintain and Enhance Our Leadership Position in Molecular Testing for Viral Diseases. We believe we are the leading provider of sophisticated tests for HIV
drug resistance and have established ourselves as a leader in this field. We believe the use of our Trofile Co-Receptor Tropism Assay for patient selection in phase III clinical trials of CCR5 antagonists potentially opens a new era in molecular
testing for HIV patients. We plan to maintain our leadership position by continuing a strong emphasis on the scientific basis for our products and applying our scientific expertise to other infectious diseases.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Develop a Leadership Position in Products to Guide Cancer Treatments. We intend to develop a market position in oncology that mirrors the leadership position
we have built in infectious disease, through our proprietary eTag technology. New targeted cancer drugs that are approved for marketing provide an outstanding opportunity for our expertise in developing tools that can differentiate likely
responders and non-responders in a large patient population.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Leverage Our Relationships with the Pharmaceutical/Biotechnology Industry. We believe we are the partner of choice for pharmaceutical companies seeking
molecular testing for HIV drugs in development. Our drug resistance tests have been used in the testing of patient samples for every drug approved for treatment of HIV in the past five years and we are currently working with almost every company
with a significant HIV drug development program. We intend to leverage our expertise and position by enhancing our product portfolio for patient testing as these drugs are approved and brought to market. In addition, several of the leading HIV drug
developers are also leaders in the development of cancer therapies and we intend to leverage our existing relationships by offering a more comprehensive set of capabilities to pharmaceutical and biotechnology companies initially in oncology and
subsequently in other serious diseases.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Provide Broad, Convenient Access to our Products on a Worldwide Basis. We have created broad access to our current commercial products in the United States
by focusing on reimbursement, education and distribution. In the U.S., we have relationships, providing broad access to our HIV tests, with Quest Diagnostics and Laboratory Corporation of America, the two largest national networks of clinical
reference laboratories in the United States and will continue to seek the broadest and most optimal distribution structure for our products. We intend to make our Trofile Co-Receptor Tropism Assay available outside of the U.S. through our
collaboration with Pfizer. For our future oncology products, we intend to utilize the same commercial approach in the U.S. and intend to access major international markets, either directly or through partnerships.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Develop strategic partnerships to optimize the development of our business. We will seek partnerships related to technologies, products and commercialization
approaches where these can enhance our technology platforms or our market position.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Maintain a Strong Intellectual Property Portfolio. We have a significant portfolio of patents and patent applications related to our products and
technologies. We intend to continue to enhance this portfolio to maintain a strong proprietary position.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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Sales & Marketing

We market our HIV tests to physicians and pharmaceutical customers in the United States through both a direct and indirect sales organization. We have built an efficient commercial infrastructure to support the
industrys most comprehensive line of drug resistance and patient screening tests currently available. Our commercial organization is composed of approximately 60 people in sales, marketing, customer service, payor relations and sales
management functions.

We market our tests to physicians in the United States directly to physician offices and indirectly through
national, regional and hospital laboratories. We have contracts and alliances with Quest Diagnostics and Laboratory Corporation of America, the two largest national networks of laboratories in the United States. These alliances allow for streamlined
collection of blood specimens as well as convenience for physicians who desire to consolidate testing for payors. In 2006, 21% of our resistance tests came from third party reference laboratories.

We intend to market our Trofile Co-Receptor Tropism Assay outside of the United States through our collaboration with Pfizer, Inc. On May 5, 2006,
we entered into a Collaboration Agreement with Pfizer regarding our Trofile Assay (the Collaboration Agreement). The Collaboration Agreement has an initial term that expires on December 31, 2009, and is renewable by Pfizer for five
successive one-year terms.

Under the agreement, we will collaborate with Pfizer to make our Trofile Co-Receptor Tropism Assay available
globally. We will be responsible for making the assay available in the U.S. and performing the assay in accordance with agreed upon performance standards. We will also be obligated to undertake certain efforts to plan for, establish and maintain an
infrastructure to support the commercial availability of the assay outside the U.S. in countries designated by Pfizer, and we will be obligated to perform the assay with respect to patient blood samples originating outside of the U.S. in accordance
with agreed upon performance standards. Pfizer will be responsible for sales, marketing and regulatory matters related to the assay outside of the U.S. Pfizer will reimburse us for costs incurred in establishing and maintaining the necessary
logistics infrastructure to make the assay available outside of the U.S., and Pfizer will pay us for each assay that we perform with respect to patient blood samples originating outside of the U.S.

Subject to certain limitations, Pfizer will be entitled to establish its own facility to perform the assay in support of its human clinical trials, and
to perform the assay in respect of patient blood samples in the event of certain uncured material breaches by us of the Collaboration Agreement (including the performance standards). For such purposes, we have granted Pfizer a license to use certain
intellectual property rights and proprietary materials related to our Trofile Co-Receptor Tropism Assay. We will be obligated in such a case to assist Pfizer in establishing and operating such facility, for which Pfizer will reimburse us for all
costs that we incur in providing such assistance. To secure our obligations under the license described above, we have granted Pfizer a security interest in certain of our intellectual property rights and proprietary materials related to the Trofile
Co-Receptor Tropism Assay. We have also extended the co-receptor assay portion of the existing services agreement between Monogram and Pfizer for support of potential additional Pfizer clinical trials through December 31, 2009.

We expect to leverage our existing experience and infrastructure to commercialize products for the oncology market. As we will be marketing to a separate
physician group, we expect to hire sales personnel dedicated to the oncology market. We have hired a senior executive to lead this effort and have made other management additions in 2006 to our commercial organization in anticipation of commercial
introduction of products for the oncology market. We plan to hire sales and educational personnel within this organization prior to the commercial introduction of such products.

Our marketing strategies focus on physician, patient and payor education in order to increase market awareness of our resistance testing products. We
routinely sponsor and participate in conferences and scientific meetings, sponsor educational forums for physicians, and advertise in relevant journals and publications. Additionally, we target patients directly through educational programs. As part
of our effort to maintain scientific leadership within the clinical community, which represents our customer base, we have a clinical advisory board consisting of leading clinicians.



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We have an active reimbursement strategy, and educate both private and public payors concerning the
benefits of our molecular diagnostic testing services in an effort to maximize reimbursement. We believe that over 75% of HIV/AIDS patients in the United States now have access to coverage for resistance testing. At the end of 2006, 49 state
Medicaid programs, including California, Florida, New Jersey and New York, the states with the largest HIV/AIDS patient populations, had favorable coverage policies for drug resistance testing. Medicare and nearly all private payors, including
Aetna, the Blue Cross Blue Shield Association, Humana and United Health Care, pay for HIV resistance testing. We intend to leverage this experience as we introduce molecular diagnostic testing products for oncology.

Research & Development

Research and
development expenditures were $19.0 million, $19.0 million and $7.8 million in 2006, 2005 and 2004, respectively. In addition, in 2004, we recorded a non-cash charge of $100.6 million as an allocation of the purchase price of ACLARA to in-process
research and development programs. This reflects the proprietary eTag technology, based on which we are developing products for therapy guidance in oncology for use by pharmaceutical companies and physicians.

As of February 9, 2007 we had 54 employees in research and development and clinical research activities, of whom approximately 40% were primarily
focused on infectious disease programs, and 60% were primarily focused on oncology programs.

We maintain an active effort to seek grant
funding in support of research programs. Revenue from grants was $1.8 million, $2.3 million and $2.0 million in 2006, 2005 and 2004, respectively. These grants will help support the development of analytical and database tools to facilitate the
identification and characterization of drug resistant strains of HIV, and assays that will aid in the pre-clinical and clinical evaluation of the next generation of anti-viral therapeutics and vaccines.

Competition

The markets for life science research
and diagnostic products are highly competitive and are subject to rapid technological change. In particular, approaches to personalized medicine are rapidly evolving and there are many companies attempting to establish their technological approaches
and products as the standard of care.

For our HIV resistance testing products, the principal competitors include Tibotec-Virco, a division
of Johnson & Johnson, Specialty Laboratories, Applied Biosystems Group, Visible Genetics, a division of Siemens, Viralliance, and reference and academic laboratories performing genotypic testing. For our Trofile Co-Receptor Tropism Assay,
we are not aware of any other products currently available for this application. However, we are aware of efforts by third parties to develop competitive assays using phenotypic and genotypic approaches. Genotypic approaches to the identification of
tropism are thought to be significantly less precise than our phenotypic approach.

For diagnostic testing for cancer therapies, we expect
to compete with companies that are developing alternative technological approaches for patient testing in the cancer field. There are likely to be many competitive companies and many technological approaches in the emerging field of testing for
likely responsiveness to the new class of targeted cancer therapies, including companies such as DakoCytomation A/S, Genzyme and Abbott Laboratories that currently commercialize testing products for guiding therapy of cancer patients. Established
diagnostic product companies such as Abbott Laboratories, Roche Diagnostics and Bayer Diagnostics and established clinical laboratories such as Quest Diagnostics and Laboratory Corporation of America may also develop or commercialize services or
products that are competitive with those that we anticipate developing and commercializing. In addition, there are a number of alternative technological approaches being developed by competitors and evaluated by pharmaceutical and biotechnology
companies and being studied by the oncology community. In particular, while our anticipated oncology testing products will be based on the identification of protein-based differences among patients, there is significant interest in the oncology
community in gene-based approaches that may be available from other companies.



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We believe that the principal competitive factors in our markets are product capability supported by
clinical validation, scientific credibility and reputation, customer service, cost effectiveness of the technology and the sales and marketing strength of the supplier.

Many of our competitors and potential competitors in these markets have substantially greater market presence and substantially greater financial, technical and human resources than we do. We cannot assure you that
they will not succeed in developing technologies and products that would render our technologies and products obsolete and noncompetitive. We also cannot assure you that we will be able to compete effectively with these competitors greater
marketing presence and financial strength.

Operations

We perform our HIV testing in South San Francisco, California. Our clinical laboratory is accredited by the College of American Pathologists and our facility is subject to stringent CLIA operating regulations. Patient
samples for testing are delivered by courier and treated as infectious specimens. After processing of the samples with our proprietary technology, results are reported to the customer. The CLIA regulations require that we meet certain quality and
personnel standards and undergo proficiency testing and inspections.

We are in the process of transferring our eTag assays from the
research setting to our CLIA certified clinical laboratory in South San Francisco, California. Our eTag assays are currently being run in our clinical laboratory to demonstrate reproducibility and establish standardized formats that can be
validated in accordance with CLIA standards and procedures, including documentation and quality procedures comparable to those applicable to our HIV testing products.

While initial products for the cancer market are expected to be introduced through our CLIA certified clinical laboratory, future cancer testing products may include test kits that may be subject to the regulatory
authority of the Food and Drug Administration, or the FDA. The FDA regulatory framework is complicated, and we have limited experience at managing FDA compliance issues. If we develop cancer test kits, the kits could be subject to premarket FDA
approval requirements, which would be expensive and time-consuming, and could delay or prevent us from marketing these tests. In addition, the production of the future cancer test kits may be subject to Good Manufacturing Practice Regulation, or
GMP, under the auspices of the FDA. Our facilities are not GMP compliant. If the manufacture of the proposed kits is subject to GMP regulation, we will be required to establish a GMP compliant facility, or to enter into a relationship with a third
party manufacturer that operates a GMP compliant facility. We do not have experience with GMP compliance. GMP compliance, or entry into a manufacturing relationship with a third party manufacturer, would be time-consuming and expensive.

Patents and Proprietary Rights

Our Intellectual Property
Strategy

We will be able to protect our technology from unauthorized use by third parties only to the extent that our proprietary
rights are covered by valid and enforceable patents or are effectively maintained as trade secrets. Patents and other proprietary rights are an essential element of our business. Our policy is to file patent applications and to protect technology,
inventions and improvements to inventions that are commercially important to the development of our business. Our commercial success will depend in part on obtaining this patent protection.

With respect to our viral disease portfolio, we currently have approximately 98 granted, issued, allowed, and pending patent applications in the United
States and in other countries, including 45 issued patents. With respect to our potential oncology products and eTag technology, we currently have approximately 57 granted, issued, allowed, and pending patent applications in the United States
and in other countries, including 20 issued patents. We have 110 granted, issued, allowed, and pending patent applications in the United States and in other countries, including 87 issued or allowed patents, relating to the historic microfluidics
business of ACLARA. We have licensed certain patents and technologies as described below.



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Our patents and patent applications related to our eTag technology and products in development
address the following essential areas: Biomarkers identified by eTag technology, including the recognition, determination and quantification of protein-protein complexes, such as cell-surface receptor dimers and intracellular factors, to
indicate disease status, particularly in the cancer field; and eTag technology, including compositions, methods and applications related to gene expression and recognition, determination and quantification of protein-protein interactions,
post-translational modification of proteins and/or protein activation, particularly as those processes relate to cell-based assays for quantification of dimerized receptors and analysis of signal transduction pathways. Patents related to
ACLARAs historic microfluidics business address microfluidic and nanofluidic instruments and devices, their fabrication and their applications.

Our patents and patent applications related to our viral disease portfolio address the following essential aspects of resistance testing: 1) assessment of patient resistance to treatment regimens, including
phenotypically assessing whether a patient is likely to respond to treatments targeted to viral protein targets, such as protease inhibitors or reverse transcriptase (RTs), or whether a patient is likely to respond to a treatments targeted to viral
processes more generally, such as viral entry or incorporation of nucleotide analogues into the viral coding sequence; and 2) genotypic assessment of patient resistance to treatment regimens, including a comprehensive proprietary database of
mutations in viral proteins and an assessment of whether patients harboring mutations will respond to current treatment regimens.

These
patents and patent applications also include many patents around our entry and tropism assays. The phenotypic approach covered by these patents is able to directly and accurately assess the susceptibility or resistance of a patients HIV to
entry inhibitors, and to determine to what extent a patients virus is able to gain entry into cells via one or other, or a mixture, of the two major co-receptors, CCR5 or CXCR4. This approach also allows us to assess how resistant a
patients virus is to entry inhibitors, to identify the tropism that a patients virus exhibits (i.e. whether it uses the CCR5 or CXCR4 co-receptor, or both), to screen for new entry inhibitor compounds, and to test for
antibody responses capable of blocking infection, a critical need in assessing HIV vaccines. In May 2006, we received notices of allowance from the United States Patent and Trademark Office on four patents in this field, two of which have
subsequently issued.

These patents and patent applications cover a broad range of technology applicable across our entire current and
planned product line. We cannot assure you that any of the currently pending or future patent applications will be issued as patents, or that any patents issued to us will not be challenged, invalidated, held unenforceable or circumvented. Further,
we cannot assure you that our intellectual property rights will be sufficiently broad to prevent third parties from producing competing products similar in design to our products.

In addition to patent protection, we also rely on protection of trade secrets, know-how and confidential and proprietary information. We generally enter
into confidentiality agreements with our employees, consultants and our collaborative partners upon commencement of a relationship with us. However, we cannot assure you that these agreements will provide meaningful protection against the
unauthorized use or disclosure of our trade secrets or other confidential information or that adequate remedies would exist if unauthorized use or disclosure were to occur. The exposure of our trade secrets and other proprietary information would
impair our competitive advantages and could have a material adverse effect on our operating results, financial condition and future growth prospects. Further, we cannot assure you that others have not or will not independently develop substantially
equivalent know-how and technology.

Further, there is a risk that some of our confidential information could be compromised during the
discovery process of any litigation. During the course of any lawsuit, there may be public announcements of the results of hearings, motions and other interim proceedings or developments in the litigation. If securities analysts or investors
perceive these results to be negative, it could have a substantial negative effect on the trading price of our stock.



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Intellectual Property of Others

Our commercial success also depends in part on avoiding the infringement of other parties patents or proprietary rights and the breach of any licenses that may relate to our technologies and products. Third
parties may have patents or patent applications relating to products or processes similar to, competitive with or otherwise related to our products. These products and processes may include technologies relating to HIV, hepatitis B and C, other
viruses and oncology technologies. Third parties have from time to time threatened to assert infringement or other intellectual property rights against us based on their patents or other intellectual property rights.

We have had to, and expect to continue to have to, enter into licenses covering the rights at issue. Unless we are able to expand our existing licenses
and obtain additional licenses, patents covering these technologies may adversely impact our ability to commercialize one or more of our potential products. We are aware of various third-party patents that may relate to our technology. We believe
that we do not infringe these patents but cannot assure you that we will not be found in the future to infringe these or other patents or proprietary rights of third parties, either with products we are currently developing or with new products that
we may seek to develop in the future. If third parties assert infringement claims against us, we may be forced to enter into license arrangements with them. Further, we may be prohibited from selling our products before we obtain a license, which,
if available at all, may require us to pay royalties. Even if infringement claims against us are without merit, defending a lawsuit will take significant time, and may be expensive and divert management attention from other business concerns. For
instance, we have been informed by Bayer Diagnostics that it believes we require one or more licenses to patents controlled by Bayer in order to conduct certain of our current and planned operations and activities. We, in turn, believe that Bayer
may require one or more licenses to patents controlled by us. Although we believe we do not need a license from Bayer for our HIV products, we initiated discussions with Bayer concerning the possibility of entering into a cross-licensing or other
arrangement in 2004. During 2005 the Bayer patents at issue in these discussions became the subject of an interference action at the United States Patent and Trademark Office. We believe that if necessary, licenses from Bayer would be available to
us on commercially acceptable terms. However, in the future, we may have to pay damages, possibly including treble damage, for infringement if it is ultimately determined that our products infringe a third partys patents.

We cannot assure you that we could enter into the required licenses on commercially reasonably terms, if at all. The failure to obtain necessary licenses
or to implement alternative approaches may prevent us from commercializing products under development and would impair our ability to be commercially competitive. We may also become subject to interference proceedings conducted in the U.S. Patent
and Trademark Office to determine the priority of inventions.

The defense and prosecution, if necessary, of intellectual property suits,
U.S. Patent and Trademark Office interference proceedings and related legal and administrative proceedings will result in substantial expense to us, and significant diversion of effort by our technical and management personnel. An adverse
determination in litigation or interference proceedings to which we may become a party could subject us to significant liabilities to third parties, could put our patents at risk of being invalidated or interpreted narrowly and could put our patent
applications at risk of not issuing.

Historically, we have licensed technology from Roche that we use in our PhenoSense and GeneSeq tests.
We held a non-exclusive license for the life of the patent term of the last licensed Roche patent. We were notified by Roche that the license had terminated in March 2005 because the last licensed patent had expired. However, Roche advised us that
additional licenses may be necessary for certain other patents and has offered us a license to these patents. We are in the process of reviewing whether additional licenses are necessary or useful for our operations. We believe such licenses are
available on commercially acceptable terms.



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Regulation and Reimbursement

Regulation of Clinical Laboratory Operations

The Clinical Laboratory Improvement Amendments of 1988 (CLIA) extends federal
oversight to virtually all clinical laboratories by requiring that laboratories be certified by the federal government, by a federally approved accreditation agency or by a state that has been deemed exempt from the regulations requirements.
We currently provide our viral disease assays, including our PhenoSense, PhenoSense GT and Trofile Co-Receptor Tropism Assays, and intend to provide our eTag Assays, under the standards of these regulations. Pursuant to these federal clinical
laboratory regulations, clinical laboratories must meet quality assurance, quality control and personnel standards. Labs also must undergo proficiency testing and inspections. Standards are based on the complexity of the method of testing performed
by the laboratory.

These regulations categorize our laboratory as high complexity, and we believe we are in compliance with the more
stringent standards applicable to high complexity testing for personnel, quality control, quality assurance and patient test management. Our clinical laboratory holds a Certificate of Registration under these regulations. Our clinical laboratory has
been surveyed by the College of American Pathologists, a federally approved accreditation agency, which has accredited our clinical laboratory. In order to offer eTag assays in our clinical laboratory for patient use we will be required to
validate those assays and related systems in accordance with our quality control, quality assurance and patient test management protocols and for specificity and reproducibility pursuant to the CLIA standards.

In addition to the Federal laboratory regulations, states, including California, require laboratory licensure and may adopt regulations that are more
stringent than federal law. We believe we are in material compliance with California and other applicable state laws and regulations.

The
sanctions for failure to comply with federal or state clinical laboratory regulations, or accreditation requirements of federally approved agencies, may be suspension, revocation or limitation of a laboratorys certificate or accreditation.
There also could be fines and criminal penalties. The suspension or loss of a license, failure to achieve or loss of accreditation, imposition of a fine, or future changes in applicable federal or state laws or regulations or in the interpretation
of current laws and regulations, could have a material adverse effect on our business.

Under our current labeling and marketing plans, our
phenotypic products have not been subject to FDA regulation, although we are aware of increasing activity by the FDA in regards to regulating homebrew HIV genotypic resistance testing such as ours.

In September 2006, the FDA issued draft guidance related to the regulation of certain kinds of tests, multivariate index assays (MIAs)
provided by CLIA labs. This draft guidance is currently subject to public comment and may be revised before being finalized. The draft guidance states that it applies to those tests provided by CLIA laboratories and that are categorized as IVD MIAs
where multiple variables are analyzed, using complex statistical proprietary algorithms and the reported results may not be understood by physicians. It is not clear which tests may be covered by the final guidance when issued, when such guidance
may be issued or what form of approval process may be required. There is no assurance that some or all of our current products and products in development, including those for HIV or for cancer based on the eTag technology, will not be
covered by the final guidance. In addition, certain members of Congress have announced that they may introduce proposed legislation regarding laboratory testing.

We cannot predict the nature or extent of future FDA, or other regulation, such as Congressional regulation, and all of our products, including our existing virology assays and our planned eTag oncology
products, might be subject in the future to greater regulation, or different regulations, that could have a material effect on our finances and operations.



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Regulation for Manufacture and Sale of Kit based Assays

We may be subject to FDA and other regulation with regard to future diagnostic kits and services that we may develop. Under the Federal Food, Drug and
Cosmetic Act and related regulations, the FDA regulates the design, development, manufacturing, labeling, sale, distribution and promotion of drugs, medical devices and diagnostics. Before a new drug, device or diagnostic product can be introduced
in the market, the product must undergo rigorous testing and an extensive regulatory approval process implemented by the FDA under federal law. In addition, the FDA imposes additional regulations on manufacturers of approved products. We have
limited experience with obtaining FDA approvals and developing, manufacturing, distributing or selling products within FDA requirements. Any failure to obtain FDA and other requisite governmental approvals with regard to any future products that we
may develop could have a material adverse affect on our business, results of operations and financial condition.

Medical Waste and Radioactive
Materials

We are subject to licensing and regulation under federal, state and local laws relating to the handling and disposal of
medical specimens and hazardous waste and radioactive materials as well as to the safety and health of laboratory employees. Our clinical laboratory facility in South San Francisco, California is operated in material compliance with applicable
federal and state laws and regulations relating to disposal of all laboratory specimens. We utilize outside vendors for disposal of specimens. Our research and development and manufacturing processes at the former ACLARA facilities in Mountain View,
California involved the use of hazardous materials, including chemicals and biological materials. Our ongoing operations also produce hazardous waste products.

We cannot eliminate the risk of accidental contamination or discharge and any resultant injury from these materials. Federal, state and local laws and regulations govern the use, manufacture, storage, handling and
disposal of these materials. We could be subject to damages in the event of an improper or unauthorized release of, or exposure of individuals to, hazardous materials. In addition, claimants may sue us for injury or contamination that results from
our use, or the use by third parties, of these materials, and our liability may exceed our total assets. Compliance with environmental laws and regulations is expensive, and current or future environmental regulations may impair our research,
development or production efforts.

Occupational Safety

In addition to its comprehensive regulation of safety in the workplace, the Federal Occupational Safety and Health Administration has established extensive requirements relating to workplace safety for healthcare
employers, including clinical laboratories, whose workers may be exposed to blood-borne pathogens such as HIV and the hepatitis virus. These regulations, among other things, require work practice controls, protective clothing and equipment,
training, medical follow-up, vaccinations and other measures designed to minimize exposure to chemicals and transmission of the blood-borne and airborne pathogens. Although we believe that we are currently in compliance in all material respects with
such federal, state and local laws, failure to comply could subject us to denial of the right to conduct business, fines, criminal penalties and other enforcement actions.

Specimen Transportation

Regulations of the Department of Transportation, the International Air
Transportation Agency, the Public Health Service and the Postal Service apply to the surface and air transportation of clinical laboratory specimens.

Regulation of Coverage and Reimbursement

Revenues for clinical laboratory testing services come from a variety of sources,
including Medicare and Medicaid programs; other third-party payors, including commercial insurers, health maintenance and other managed care organizations; and patients, physicians, hospitals and other laboratories. We are a Medicare laboratory
services provider. Medicare has issued coverage policies and payment guidelines for resistance



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testing, including phenotypic and genotypic testing. Currently, nearly all public and a majority of private payors have approved the reimbursement of our
existing HIV products. While recently issued guidelines of the Department of Health and Human Services recommend drug resistance testing for HIV patients, this does not assure coverage or level of coverage, by state, Medicare or any other payors.
However, the majority of our payors are currently reimbursing our products at varying levels from 70% to 100% of our list prices. Coverage has not been established for any of our eTag products under development.

Since 1984, Congress has periodically lowered the ceilings on Medicare reimbursement for clinical laboratory services from previously authorized levels.
In addition, state Medicaid programs are prohibited from paying more than Medicare for clinical laboratory tests. In some instances, they pay significantly less. Similarly, other payors, including managed care organizations, have sought on an
ongoing basis to reduce the costs of healthcare by limiting utilization and payment rates. Actions by Medicare or other payors to reduce reimbursement rates or limit coverage or utilization of resistance testing would have a direct adverse impact on
our revenues and cash flows. We cannot predict whether reductions or limitations will occur, though we feel some reductions are likely.

Our agreements with third-party payors, including Medicare and Medicaid, require that we identify the services we perform using industry standard codes known as the Current Procedural Terminology, or CPT, codes, which are developed by the
American Medical Association, or AMA. Most payors maintain a list of standard reimbursement rates for each such code, and our ability to be reimbursed for our services is therefore effectively limited by our ability to describe the services
accurately using the CPT codes. From time to time, the AMA changes its instructions about how our services should be coded using the CPT codes. If these changes leave us unable to accurately describe our services or are not coordinated with payors
such that corresponding changes are made to the payors reimbursement schedules, we may have to renegotiate our pricing and reimbursement rates, the changes may interrupt our ability to be reimbursed, and/or the overall reimbursement rates for
our services may decrease dramatically.

Significant uncertainty exists as to the reimbursement status of new medical products such as our
eTag products in development for oncology, particularly if these products fail to show demonstrable value in clinical studies, and our Trofile Co-Receptor Tropism Assay which we plan to commercialize after anticipated FDA approval of
Pfizers maraviroc. If government and other third-party payors do not provide adequate coverage and reimbursement for our planned products, our revenues will be reduced.

Fraud and Abuse Regulation

Existing federal laws governing Medicare and Medicaid and other federal
healthcare programs, as well as similar state laws, impose a variety of broadly described fraud and abuse prohibitions on healthcare providers, including clinical laboratories. Multiple government agencies enforce these laws. The Health Insurance
Portability and Accountability Act of 1996 provides for the establishment of a program to coordinate federal, state and local law enforcement programs. Over the last several years, the clinical laboratory industry has also been the focus of major
government enforcement actions.

One set of fraud and abuse laws, the federal anti-kickback laws, prohibits clinical laboratories from,
among other things, making payments or furnishing other benefits intended to induce the referral of patients for tests billed to Medicare, Medicaid, or certain other federally funded programs. California also has its own Medicaid anti-kickback law,
as well as an anti-kickback law that prohibits payments made to physicians to influence the referral of any patients. California laws also limit the ability to use a non-employee sales force.

Under another federal provision, known as the Stark law or self-referral prohibition, physicians who have an investment or
compensation relationship with a clinical laboratory may not, unless a statutory exception applies, refer Medicare or Medicaid patients for testing to the laboratory. In addition, a laboratory may not bill Medicare, Medicaid or any other party for
testing furnished pursuant to a prohibited referral. There is a California self-referral law, as well, which applies to all patient referrals.



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Currently, we have a financial relationship with one referring physician, who serves as part-time medical
director at our clinical laboratory. Very few of this physicians patients, if any, are federal healthcare program patients. In addition, we do not bill for services furnished to any patients referred by this physician. The California
anti-kickback law may have exceptions applicable to our relationship with this physician.

There are a variety of other types of federal
and state anti-fraud and abuse laws, including laws prohibiting submission of false or otherwise improper claims to federal healthcare programs, and laws limiting the extent of any differences between charges to Medicare and Medicaid and charges to
other parties. We seek to structure our business to comply with the federal and state anti-fraud and abuse laws. We cannot predict, however, how these laws will be applied in the future, and we cannot be sure arrangements will not be found in
violation of them. Sanctions for violations of these laws may include exclusion from participation in Medicare, Medicaid and other federal healthcare programs, criminal and civil fines and penalties, and loss of license. Any of these could have a
material adverse effect on our business.

Patient Privacy

The Department of Human Health and Services, or HHS, has issued final regulations under the Health Insurance Portability and Accountability Act of 1996, or HIPAA, designed to improve the efficiency and effectiveness
of the health care system by facilitating the electronic exchange of information in certain financial and administrative transactions, while protecting the privacy and security of the information exchanged. Three principal regulations have been
issued:



| |  |  | Privacy regulations
| | - |  | -------------------



| |  |  | Security regulations; and
| | - |  | -------------------------



| |  |  | Standards for electronic transactions, or transaction standards.
| | - |  | ----------------------------------------------------------------

The privacy regulations prohibit the use or disclosure of protected health information except for certain purposes or unless specific conditions are met. Protected health information is information
transmitted or maintained in any formby electronic means, on paper, or through oral communications that: (1) relates to the past, present, or future physical or mental health or condition of an individual, the provision of health care to
an individual, or the past, present, or future payment for the provision of health care to an individual; and (2) identifies the individual or with respect to which there is a reasonable basis to believe the information can be used to identify
the individual. Data that have been de-identified in accordance with the Privacy regulations stringent de-identification standard are not considered protected health information and are not subject to the regulation. We have implemented
privacy and security changes that we believe comply with these standards. In addition, we implemented measures we believe will reasonably and appropriately meet the specifications of the security regulations and the transaction standards.

The HIPAA regulations on transaction standards establish uniform standards for electronic transactions and code sets, including the
electronic transactions and code sets used for claims, remittance advices, enrollment and eligibility. These standards are complex, and subject to differences in interpretation. We cannot guarantee that our compliance measures will meet the
specifications for any of these regulations. In addition, certain types of information, including demographic information not usually provided to us by physicians, could be required by certain payors. As a result of inconsistent application of
requirements by payors, or our inability to obtain billing information, we could face increased costs and complexity, a temporary disruption in receipts and ongoing reductions in reimbursements and net revenues.

HHS issued additional guidance on July 24, 2003 stating that it will not penalize a covered entity for post-implementation date transactions that
are not fully compliant with the transactions standards, if the covered entity can demonstrate its good faith efforts to comply with the standards. HHS stated purpose for this flexible enforcement position was to permit health plans to
mitigate unintended adverse effects on covered entities cash flow and business operations during the transition to the standards, as well as on the availability and quality of patient care.



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The Health Insurance Portability and Accountability Act of 1996 (HIPAA) mandated that the Secretary of
Health and Human Services adopt a standard unique health identifier of health care providers. All covered health care providers, both individuals and organizations must obtain a National Provider Identifier (NPI) for use on all HIPAA-related
electronic transactions. The compliance date for obtaining and using an NPI is May 23, 2007. The NPI will be the sole provider identifier and will replace the multiple provider identification numbers currently used. We have been notified by
some payers (both major and minor) that they will not meet this deadline and cannot accept NPI until December, 2007. At this time, we cannot estimate the potential impact of payers implementing, or failing to implement the HIPAA standard on our cash
flows and results of operations.

In addition to the HIPAA provisions described above, there are a number of state laws regarding the
confidentiality of medical information, some of which apply to clinical laboratories. These laws vary widely, and new laws in this area are pending, but they most commonly restrict the use and disclosure of medical information without patient
consent. Penalties for violation of these laws include sanctions against a laboratorys state licensure, as well as civil and/ or criminal penalties. Compliance with such rules could require us to spend substantial sums, which could negatively
impact our profitability.

Employees

As of February 9, 2007, we had 323 employees, of whom 36 hold Ph.D. or M.D. degrees and 54 hold other advanced degrees. Approximately, 176 employees are engaged in clinical laboratory, process development and supporting operations, 54
employees are engaged in research and development and clinical research activities, 60 employees are engaged in sales and marketing and 33 are engaged in general and administrative functions.

Available Information

We maintain a site on the
worldwide web at www.monogrambio.com; however, information found on our website is not incorporated by reference into this report. We make available free of charge on or through our website our SEC filings, including our annual report on Form
10-K, quarterly interim reports on Form 10-Q, current reports on Form 8-K and amendments to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the Exchange Act as soon as reasonably practicable after we electronically file
such material with, or furnish it to, the SEC.

Item 1A.Risk Factors

Except for the historical information contained or incorporated
by reference, this annual report on Form 10-K and the information incorporated by reference contains forward-looking statements that involve risks and uncertainties. Our actual results may differ materially from those discussed here. Factors that
could cause or contribute to differences in our actual results include those discussed in the following section, as well as those discussed in Part I, Item 1 entitled Business, Part II, Item 7 entitled Managements
Discussion and Analysis of Financial Condition and Results of Operations and elsewhere throughout this annual report and in any other documents incorporated by reference into this annual report. You should consider carefully the following risk
factors, together with all of the other information included in this annual report on Form 10-K. Each of these risk factors could adversely affect our business, operating results and financial condition, as well as adversely affect the value of an
investment in our common stock.

We have not achieved profitability and we anticipate continuing losses, which may cause our stock price to fall.

We have experienced significant losses each year since inception, and we expect to continue to incur additional losses as we complete
the development of the eTag technology and commercialize products for oncology. We have experienced losses applicable to common stockholders of $38.7 million for the year ended December 31, 2006. As of December 31, 2006, we had an
accumulated deficit of approximately $264.0 million,



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including a charge in 2004 of $100.6 million for in-process research and development related to our merger with ACLARA. We expect to continue to incur
losses, primarily as a result of expenses related to:



| |  |  | research and product development costs, including the continued development and validation of the eTag technology and products based on that technology;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | clinical studies to validate the effectiveness of eTag assays as tests for responsiveness of cancer patients to particular cancer therapies;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | sales and marketing activities related to existing and planned products, including the development of a sales organization focused on the oncology market;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | general and administrative costs to support growth of the business;
| | - |  | -------------------------------------------------------------------



| |  |  | interest expense related to outstanding debt;
| | - |  | ---------------------------------------------



| |  |  | adjustments in our statement of operations to reflect changes in the fair value of the embedded derivatives in our outstanding convertible debt;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | cost of relocating to new facilities on expiry of current leases, and higher market rent and capital and operating expenses as a result of the need for additional
laboratory and office.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

If our losses continue, our liquidity may be impaired, our stock price may fall and our
stockholders may lose part or all of their investment.

New classes of drugs for treatment of HIV may not be successful in clinical trials and may not
be approved by the FDA, the drugs may not require our testing services when approved. If the drugs are approved by the FDA and require our testing services, we may not be able to adequately meet the demand for these services in all markets.

Our testing services, including our Trofile Co-Receptor Tropism Assay, have been used by certain pharmaceutical company customers,
including Pfizer, in phase III clinical trials of the new class of CCR5 antagonist drugs. Pfizers trial has been completed. Accordingly, revenue from this trial, and total revenue have been reduced in the third and fourth quarters of 2006 and
are expected to be similarly reduced in at least the first two quarters of 2007.

If new drugs are approved, patient testing use of the
Trofile assay could be an important source of future testing revenue. However, the progress of such clinical trials and the likelihood of trials being successful and the drugs receiving FDA approval are subject to significant uncertainty and are
determined by factors outside of our control. Difficulties encountered by our pharmaceutical company customers related to patient enrollment, drug performance, regulatory considerations and other factors could cause the trials to be delayed or
terminated or cause the drugs not to get approved. If such events occurred, our revenues would be adversely affected and could decline. If safety or efficacy concerns arise related to the entire class of CCR5 antagonists, all clinical trials related
to this class of drugs could be terminated and the drugs might not be approved by the FDA, which would abruptly and negatively impact our revenues. There is also no guarantee that our testing services will be required or used by physicians if the
drugs are approved by the FDA. If such use does not develop after approval then these drugs will not generate significant future patient testing revenues. If the drugs are approved and our testing services are required for these drugs, we may not be
able to deliver our testing services on a global basis in support of the drugs, which could damage our market position, adversely affect our business, and cause our revenues to decline. While there are a number of such new drugs in development,
Pfizers CCR5 antagonist, maraviroc, that has been the subject of the clinical trial referenced above is significantly further advanced in the clinical and regulatory process than any other CCR5 antagonist. An NDA for maraviroc
has been submitted by Pfizer and has been accepted by the FDA for priority review. Any difficulty related to this drug in particular would have a serious adverse affect on our revenues and business.



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We derive a significant portion of our revenues from a small number of customers and our revenues may decline
significantly if any major customer cancels, reduces or delays a purchase of our products.

Our revenues to date consist, and are
anticipated to consist in 2007, largely of sales of HIV testing products. We have significant customer concentration and the loss of any major customer or the reduced use of our products by a major customer could have a significant negative impact
on our revenue. Our revenue derived from tests performed for beneficiaries of the Medicare and Medicaid programs represented approximately 21%, 22% and 31% in 2006, 2005 and 2004, respectively. Additionally, in 2006, 2005 and 2004, Pfizer
represented approximately 19%, 19% and 7%, Quest Diagnostics Incorporated represented approximately 11%, 11% and 12% and GlaxoSmithKline plc represented approximately 6%, 10% and 4% of our total revenue, respectively. Gross accounts receivable
balances from Medicare and Medicaid represented 27% and 33% of gross accounts receivable balance at December 31, 2006 and 2005, respectively. It is likely that we will have significant customer concentration in the future. Following our entry
into a Collaboration Agreement with Pfizer in May 2006, and the amendment of our services agreement with Pfizer, we expect Pfizers significance as a customer will grow. Although certain of our agreements with pharmaceutical company customers
have provisions for minimum purchases, these provisions are generally subject to annual renewal or cancellation provisions. The loss of any major customer, a slowdown in the pace of increasing physician and physician group sales as a percentage of
sales, cancellation or non-renewal of agreements with pharmaceutical company customers, the delay of significant orders from any significant customer, even if only temporary, or delays or terminations of clinical trials by pharmaceutical company
customers, could have a significant negative impact on our revenues and our ability to fund operations from revenues, generate cash from operations or achieve profitability.

We may be unable to perform under our collaboration agreement with Pfizer, which could adversely affect our business.

Our collaboration agreement with Pfizer requires us to make our Trofile Co-Receptor Tropism Assay available in the United States and to perform the assay for Pfizer in accordance with agreed upon performance
standards. We are also obligated to undertake certain efforts to plan for, establish and maintain an infrastructure to support the availability of the assay in countries outside the United States designated by Pfizer.

We have never been subject to breach remedies in the case of failure to meet performance standards like those in the Pfizer collaboration agreement, and
we may be unable to meet them. The performance standards include standards regarding shipment times, assay turnaround times, percent of unscreenable samples and assay sensitivity. In addition, patient blood samples originating outside the United
States will be included in the overall performance standards. We anticipate that under the collaboration agreement we will receive patient samples from countries and laboratories that we have not previously dealt with, although individual sites and
countries must meet minimum volume and performance standards before they are included in the overall performance standard calculations. Samples from these sources may not be consistently collected or maintained in accordance with our requirements,
which could make a sample unscreenable or lead to unacceptable variability in the assay results. While we and Pfizer have agreed to exclude third party sample collection problems from the measurement of our performance under the collaboration
agreement, there may be instances where we are unable to identify a sample collection problem, or where we and Pfizer disagree as to whether or not a performance issue is attributable to such a problem. In performing under the collaboration
agreement, we will need to contract with third party laboratories outside the United States. We do not have experience in negotiating and managing relationships with overseas laboratories, and may have difficulty doing so. In addition, we anticipate
that certain HIV variants will be more prevalent in patient populations in some countries from which we will be receiving patient samples under the collaboration, and with which we do not have extensive prior experience. Our assay may not work
effectively with these variants, or may require additional enhancements. The foregoing and other factors may make us unable to perform under our collaboration with Pfizer, which could constitute a material breach of the collaboration agreement.



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Following certain uncured material breaches by us under the collaboration agreement, including our
failure to achieve the performance standards, Pfizer will be entitled to establish its own facility, with our assistance, to perform the assay in support of its human clinical trials, and to perform the assay in respect of patient blood samples. For
these purposes, we have granted Pfizer a license to use intellectual property rights and proprietary materials related to the assay, secured by a security interest in favor of Pfizer, in intellectual property rights and proprietary materials related
to the assay. Pfizer would pay us a royalty for each such assay that it performs. If we materially default under the collaboration agreement, including failing to achieve the performance standards, and Pfizer becomes entitled to use our intellectual
property and proprietary materials to establish its own facility, our business could be significantly and adversely impacted by this potential loss in service revenue from Pfizer.

We are currently restricted by accounting rules in our ability to recognize revenue from activities under the collaboration agreement with Pfizer, impacting our revenue and profitability.

In accordance with Emerging Issues Task Force Issue No. 00-21, Revenue Arrangements with Multiple Deliverables, (EITF 00-21)
revenue arrangements entered into after June 15, 2003, that include multiple element arrangements are analyzed to determine whether the deliverables are divided into separate units of accounting or as a single unit of accounting. Revenues are
allocated to a delivered product or service when all of the following criteria are met: (1) the delivered item has value to the customer on a standalone basis; (2) there is objective and reliable evidence of the fair value of the
undelivered item; and (3) if the arrangement includes a general right of return relative to the delivered item, delivery or performance of the undelivered item is considered probable and substantially in our control. If all of the three
required criteria under EITF 00-21 are met, then the deliverables would be accounted for separately, as performed. Otherwise, the arrangement would be accounted for as a single unit of accounting and the payments for performance obligations would be
recognized as revenue over the estimated period of when the performance obligations are performed. If we cannot reasonably estimate when a performance obligation either ceases or becomes inconsequential, then revenue is deferred until we can
reasonably estimate when the performance obligation ceases or becomes inconsequential.

The Pfizer collaboration is a multiple element
arrangement, including supply of the Trofile Assay in additional clinical studies (including early access programs in both the U.S. and outside the U.S.), supply of the Trofile Assay for clinical use outside of the U.S., reimbursement of costs for
the establishment and operation of supply infrastructure outside of the U.S. and potential assistance to Pfizer in the establishment and operation of a second facility for processing of tropism assays. Under the guidelines of EITF 00-21, we have
determined that the collaboration with Pfizer should be accounted for as a single unit of accounting due to the absence of established fair values of certain undelivered elements. Accordingly, we have deferred revenue under this collaboration until
the earlier of establishment of fair values or completion of the deliverables. Additionally, related direct costs that are contractually reimbursable on a non-refundable basis under this collaboration have been deferred. We anticipate the
application of these accounting rules will prevent us from recognizing any revenue under the Pfizer collaboration for at least several years, until the expiry or termination of the agreement, or the completion of certain deliverables, which we
anticipate will be at least several years, if not longer, which would adversely affect our profitability.

Proposed new products based on theeTagtechnology could be delayed or precluded by regulatory, clinical or technical obstacles, thereby delaying or preventing the development, introduction and commercialization of these new products and adversely impacting our revenue and
profitability.

We are developing testing products for use in connection with the treatment of cancer patients. These products will be
based on the proprietaryeTag technology and are expected to leverage our experience in patient testing for HIV. We expect that the development and commercialization ofeTag assays for use in clinical trials by pharmaceutical and
biotechnology customers could exceed one year. In addition, we expect to commercialize clinical assays for diagnostic use in patient testing, upon the successful completion of product development and automation for high throughput, validation of
assays in a Clinical Laboratory Improvement Amendments, or CLIA, certified laboratory format, and attainment of clinical validation through clinical trials, which could also exceed one year. The completion of these research and development
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uncertainties including the extent of clinical trials required for regulatory and marketing purposes, the timing and results of clinical trials, inability to
access tumor samples on which to conduct studies of the correlation between measurements by eTag assays and clinical outcomes, failure to validate the technology in clinical trials and failure to achieve necessary regulatory approvals. These
factors make it impossible to predict with any degree of certainty whether we will be able to complete the development of commercial products utilizingeTag technology or if we are able to do so what the cost and timing of such completion may
be.

The FDA may impose medical device regulatory requirements on our tests, including possible premarket approval requirements, which could be
expensive and time-consuming and could prevent us from marketing these tests.

In
the past, the FDA has not required that genotypic or phenotypic testing for HIV conducted at a clinical laboratory be subject to premarketing clearance or approval, although the FDA has stated that it believes its jurisdiction extends to tests
generated in a clinical laboratory. We received a letter from the FDA in September 2001 that asserted such jurisdiction over in-house tests like our HIV resistance tests, but which also stated the FDA was not currently requiring premarket approval
for HIV monitoring tests such as ours provided that the promotional claims for such tests are limited to its analytical capabilities and do not mention the benefit of making treatment decisions on the basis of test results. The FDA letter to us also
asserted that our GeneSeqtest had been misbranded due to the use of purchased analyte specific reagents, or
ASRs, if test reports did not include a statement disclosing that the test has not been cleared or approved by the FDA. Since 2002, we have utilized in-house prepared ASRs in our products. The FDA has indicated in discussions that the focus of the
letter was our genotypic tests and not our phenotypic tests, but there is no certainty its focus will remain narrow.

As our Trofile
Co-Receptor Tropism Assay has been used in phase III trials of CCR5 inhibitor drug candidates, we filed a master file with the FDA providing information about the specification and validation of the assay. We have had discussions with the FDA
regarding this information and the use of our tests as a patient selection tool in such trials. While we currently believe that we will be able to provide our Trofile Co-Receptor Tropism Assay as a CLIA based service for use as a patient selection
tool for CCR5 drugs once those drugs are approved by the FDA, there is no guarantee that the FDA will not seek to regulate such services.

In September 2006, the FDA issued draft guidance related to the regulation of certain kinds of tests, multivariate index assays (MIAs) provided by CLIA labs. This draft guidance is currently subject to public comment and may be
revised before being finalized. The draft guidance states that it applies to those tests provided by CLIA laboratories and that are categorized as IVD MIAs where multiple variables are analyzed, using complex statistical proprietary algorithms and
the reported results may not be understood by physicians. It is not clear which tests may be covered by the final guidance when issued, when such guidance may be issued or what form of approval process may be required. There is no assurance that
some or all of our current products and products in development, including those for HIV or for cancer based on the eTag technology, will not be covered by the final guidance. In addition, certain members of Congress have announced that they
may introduce proposed legislation regarding laboratory testing.

Either as a result of a decision to produce future test kits, or as a
result of FDA regulation or other regulation, of our laboratory testing business, we may become subject to Good Manufacturing Practice Regulation, or GMP, under the auspices of the FDA. Our facilities are not GMP compliant. If our operations are
subject to GMP regulation, then we will be required to establish a GMP compliant facility, or to enter into a relationship with a third party manufacturer that operates a GMP compliant facility. We do not have experience with GMP compliance. GMP
compliance, or entry into a manufacturing relationship with a third party manufacturer, would be time-consuming and expensive. We anticipate that if we are required to establish our own GMP compliant facility, or we elect to enter into a
relationship with a GMP compliant third party, either process would be completed in parallel with developing the proposed testing products, could take over one year, and would require significant start-up costs and would significantly increase
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We cannot be sure that the FDA will accept the steps we take, or that the FDA will not require us to
alter our promotional claims or undertake the expensive and time-consuming process of seeking premarket approval with clinical data demonstrating the sensitivity and specificity of our currently offered tests or tests in development, including tests
for oncology based on oureTag technology. If premarket approval is required, we cannot be sure that we will be able to obtain it in a timely fashion or at all; and in such event the FDA would have authority to require us to cease marketing
tests until such approval is granted.

In general, we cannot predict the extent of future FDA or other regulation, including congressional,
of our business. In the future, we might be subject to greater or different regulations that could have a material effect on our finances and operations. If we fail to comply with existing or additional FDA regulations, it could cause us to incur
civil or criminal fines and penalties, increase our expenses, prevent us from increasing revenues, or hinder our ability to conduct our business.

With
the broadening of our business from infectious disease to oncology, we are a larger and broader organization. If our management is unable to adequately manage the company, our operating results will suffer.

As of February 9, 2007, our total number of employees was 323. Our proposed testing products using theeTag technology and our
commercialization infrastructure have not yet been developed, and the two will need to be integrated as a necessary part of the development process. We do not have experience in commercializing testing products for use in the oncology field. We face
challenges inherent in efficiently managing an increased number of employees and addressing new markets, including the need to implement appropriate systems, policies, benefits and compliance programs and the need to build a sales organization
focused on oncologists.

Difficulties or delays in successfully managing the substantially larger and broader organization could have a
material adverse effect on our business and, as a result, on the market price of our common stock.

We could lose key personnel, which could materially
affect our business and require us to incur substantial costs to recruit replacements for lost personnel.

We consider William D. Young,
Chairman and Chief Executive Officer, Christos J. Petropoulos, Ph.D., Vice President, Research and Development and Chief Scientific Officer, Michael Bates, M.D., Vice President, Clinical Research, and Jeannette Whitcomb, Ph.D., Vice President,
Operations, to be key to the management of our business and operations.

Any of our key personnel could terminate their employment at any
time and without notice. We do not maintain key person life insurance on any of our key employees. Any failure to attract and retain key personnel could have a material adverse effect on our business.

Charges to operations resulting from the possible future impairment of goodwill and intangible assets may adversely affect the market value of our common stock.

If we are unable to successfully develop products based on our eTag technology, our financial results, including earnings (loss)
per common share, could be adversely affected. In accordance with United States generally accepted accounting principles, we have accounted for the merger with ACLARA as a business combination. We have allocated the total purchase price to the
acquired net tangible assets, amortizable intangible assets, and in-process research and development based on their fair values as of the date of completion of the merger, and have recorded the excess of the purchase price over those fair values as
goodwill.

To the extent the value of goodwill becomes impaired, we may be required to incur material charges relating to the impairment of
those assets. The additional charges could adversely affect our financial results, including earnings (loss) per common share, which could cause the market price of our common stock to decline.



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Our current products may not continue to receive market acceptance and our potential future products may not achieve
market acceptance, which could limit our future revenue.

Our ability to establish our testing products, both current and potential, as
the standard of care to guide and improve the treatment of viral diseases and cancer will depend on continued acceptance and use of our current testing products by physicians and clinicians and pharmaceutical companies, similar acceptance and use of
our potential future products and the development and commercialization of new drugs and drug classes that require or could benefit from testing services such as ours. While certain testing products for viral diseases are established, others are
still relatively new, and testing products for the treatment of cancer have not yet been developed. We cannot predict the extent to which physicians and clinicians will accept and use these testing products. They may prefer competing technologies
and products. The commercial success of these testing products will require demonstrations of their advantages and potential clinical and economic value in relation to the current standard of care, as well as to competing products. Market acceptance
of our products will depend on:



| |  |  | our marketing efforts and continued ability to demonstrate the utility of PhenoSense in guiding anti-viral drug therapy, for example, through the results of
retrospective and prospective clinical studies;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our ability to demonstrate the advantages and potential economic value of our PhenoSense testing products over current treatment methods and other resistance tests;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the success of clinical trials of the new class of CCR5 antagonists for HIV in which our testing services are being used, whether those drugs get approved by the
FDA and whether our tests are required or recommended after the drugs are approved;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the development and commercialization of competitive products for the assessment of tropism related to the use of CCR5 antagonists;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------



| |  |  | the effectiveness of Pfizer in developing the market and commercializing our Trofile Assay outside of the United States;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | our ability to demonstrate to potential customers the clinical benefits and cost effectiveness of oureTag technology, relative to competing technologies and
products;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the extent to which opinion leaders in the scientific and medical communities publish supportive scientific papers in reputable academic journals;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the extent and success of our efforts to market, sell and distribute our testing products;
| | - |  | ------------------------------------------------------------------------------------------



| |  |  | the timing and willingness of potential collaborators to commercialize our PhenoSense andeTag products and other future testing product candidates;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | general and industry-specific economic conditions, which may affect our pharmaceutical customers research and development, clinical trial expenditures and the
use of our PhenoSense andeTag products;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | progress of clinical trials conducted by our pharmaceutical customers;
| | - |  | ----------------------------------------------------------------------



| |  |  | our ability to generate clinical data indicating correlation between data recognized byeTag assays and clinical responses to particular drugs;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | changes in the cost, quality and availability of equipment, reagents and components required to manufacture or use our PhenoSense andeTag products and other
future testing product candidates;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the development by the pharmaceutical industry of anti-viral drugs and targeted medicines for specific patient populations, the success of these targeted medicines
in clinical trials and the adoption of our technological approach in these development activities; and
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our ability to develop new products.
| | - |  | ------------------------------------

If the market does not continue to accept our existing testing products, such as our PhenoSense products or does not accept our future testing products such as products based on theeTag technology, our ability to generate revenue
will be limited.



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Our revenues will be limited or diminished if changes are made to the way that our products are reimbursed, or if
government or third-party payors limit the amounts that they will reimburse for our current products, or do not authorize reimbursement for our planned products.

Government and third-party payors, including Medicare and Medicaid, require that we identify the services we perform in our clinical laboratory using industry standard codes known as the Current Procedural
Terminology, or CPT, codes, which are developed by the American Medical Association, or AMA. Most payors maintain a list of standard reimbursement rates for each such code, and our ability to be reimbursed for our services is therefore effectively
limited by our ability to describe the services accurately using the CPT codes. From time to time, the AMA changes its instructions about how our services should be coded using the CPT codes. If these changes leave us unable to accurately describe
our services or we are not coordinated with payors such that corresponding changes are made to the payors reimbursement schedules, we may have to renegotiate our pricing and reimbursement rates, the changes may interrupt our ability to be
reimbursed, and/or the overall reimbursement rates for our services may decrease dramatically. In addition, we may spend significant time and resources to minimize the impact of these changes on reimbursement.

Government and third-party payors are attempting to contain or reduce the costs of healthcare and are challenging the prices charged for medical products
and services. In addition, increasing emphasis on managed care in the United States will continue to put pressure on the pricing of healthcare products. This could in the future limit the price that we can charge for our products or cause
fluctuations in reimbursement rates for our products. This could hurt our ability to generate revenues. Significant uncertainty exists as to the reimbursement status of new medical products like the products we are currently developing and that we
expect to develop, such as the Trofile Co-Receptor Tropism Assay and eTag Assays for oncology. This will especially be the case if these products fail to show demonstrable value in clinical studies. If government and other third-party payors
do not continue to provide adequate coverage and reimbursement for our testing products or do not authorize reimbursement for our planned products, our revenues will be reduced.

Our indebtedness and debt service obligations have increased as a result of the issuance of our convertible note to Pfizer in the principal amount of $25 million, our issuance of 0% convertible senior unsecured
notes, in the principal amount of $30 million, and our entry into a credit and security agreement with Merrill Lynch, which individually or in the aggregate may adversely affect our cash flow, cash position and stock price.

As a result of the sale and issuance of $30 million principal amount of 0% convertible senior unsecured notes in January 2007 to a single qualified
institutional buyer, our entry into a credit and security agreement with Merrill Lynch Capital, or Merrill, in September 2006 which provides us with a revolving credit line of up to $10 million, and our issuance of a convertible note to Pfizer in
the principal amount of $25 million in May 2006, we increased our total debt and debt service obligations. If we issue other debt securities or enter into other debt obligations in the future, our debt service obligations will increase further.

We intend to fulfill our debt service obligations from our existing cash. In the future, if we are unable to generate cash or raise
additional cash through financings sufficient to meet these obligations and need to use existing cash in order to fund these obligations, we may have to delay or curtail research, development and commercialization programs.

Our indebtedness could have significant additional negative consequences, including, without limitation:



| |  |  | requiring the dedication of a portion of our expected cash flow to service our indebtedness, thereby reducing the amount of our expected cash flow available for
other purposes, including funding our research and development programs and other capital expenditures;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | increasing our vulnerability to general adverse economic conditions;
| | - |  | --------------------------------------------------------------------



| |  |  | limiting our ability to obtain additional financing;
| | - |  | ----------------------------------------------------



| |  |  | placing us at a possible competitive disadvantage to less leveraged competitors and competitors that have better access to capital resources; and
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | Requiring us to reflect adjustments in our statement of operations to reflect changes in the fair value of the embedded derivatives in our outstanding convertible
debt.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Our outstanding senior indebtedness to Pfizer and Merrill Lynch Capital imposes restrictions on how we conduct our business,
and if we fail to meet our obligations under this indebtedness, our payment obligations may be accelerated and collateral for our loans may be forfeited.

In May 2006, in connection with our entry into a Collaboration Agreement, we and Pfizer entered into a Note Purchase Agreement, which we amended in January 2007, pursuant to which we sold to Pfizer a 3% Senior Secured
Convertible Note in the principal amount of $25 million. The Pfizer Note is secured by a first priority security interest in favor of Pfizer in our assets related to our HIV testing business.

Under the terms of the Pfizer Note, we are prohibited from incurring certain types of indebtedness, from permitting certain liens on our assets, from
entering into transactions with affiliates and from entering into certain capital transactions such as dividends, stock repurchases, capital distributions or other similar transaction without Pfizers prior consent. We are also subject to
certain other covenants as set forth in the Pfizer Note, including limitations on our ability to enter into new lines of business. These limitations imposed by the Pfizer Note could impair our ability to operate or expand our business.

In addition, in September 2006 we entered into a credit and security agreement with Merrill. Our agreement with Merrill provides us with a $10 million
revolving credit line and grants Merrill a security interest over certain of our assets, including our accounts receivable, intellectual property used or held for use in connection with our oncology testing business, and our inventory. Under the
terms of this agreement, we are also prohibited from incurring certain types of indebtedness and certain liens on our assets.

If an event
of default occurs under either of these loan arrangements, Pfizer or Merrill, as the case may be, may declare the outstanding principal balance and accrued but unpaid interest owed to them immediately due and payable, which would have a material
adverse affect on our financial position. A default under either our Pfizer or Merrill indebtedness would also trigger a default under the terms of our convertible senior unsecured notes, in the principal amount of $30 million. We may not have
sufficient cash to satisfy these obligations. If a default occurs under the Pfizer Note, and we are unable to repay Pfizer, Pfizer could seek to enforce its rights under its first priority security interest in our assets related to our HIV testing
business. If this were to happen, Pfizer may receive some or all of the assets related to our HIV testing business in satisfaction of our debt, which could cause our business to fail. Similarly, if a default occurs under our agreement with Merrill,
and we are unable to repay Merrill, Merrill could seek to enforce its security interest in the assets it has secured, including our accounts receivable, intellectual property used or held for use in connection with our oncology testing business, and
our inventory, which could also cause our business to fail.

Billing complexities associated with health care payors could delay our accounts receivable
collection, impair our cash flow and limit our ability to reach profitability.

Billing for laboratory services is complex. Laboratories
must bill various payors, such as Medicare, Medicaid, insurance companies, doctors, employer groups and patients, all of whom have different requirements. Our revenue derived from tests performed for beneficiaries of the Medicare and Medicaid
programs represented approximately 21%, 22% and 31% in 2006, 2005 and 2004, respectively. In addition, gross accounts receivable balances from Medicare and Medicaid represented 27% and 33% of gross accounts receivable balance at December 31,
2006 and 2005, respectively. Billing difficulties often result in a delay in collecting, or ultimately an inability to collect, the related receivable. This impairs cash flow and ultimately reduces profitability if we are required to record bad debt
expense and/or contractual adjustments for these receivables. Our accounts receivable balances have decreased in 2006 from 2005 but increased in 2005 from 2004. We recorded bad debt expense of $0.4 million and $0.8 million for the years ended
December 31, 2006 and 2005, respectively.

Among many other factors complicating billing are:



| |  |  | complexity of procedures, and changes in procedures, for electronic processing of insurance claims;
| | - |  | ---------------------------------------------------------------------------------------------------



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| |  |  | cumbersome nature of manual processes at payors for processing claims where electronic processing is not possible;
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | pricing or reimbursement differences between our fee schedules and those of the payors;
| | - |  | ---------------------------------------------------------------------------------------



| |  |  | changes in or questions about how products are to be identified in the requisitions;
| | - |  | ------------------------------------------------------------------------------------



| |  |  | disputes between payors as to which party is responsible for payment;
| | - |  | ---------------------------------------------------------------------



| |  |  | disparity in coverage among various payors; and
| | - |  | -----------------------------------------------



| |  |  | difficulties of adherence to specific compliance requirements and procedures mandated by various payors.
| | - |  | --------------------------------------------------------------------------------------------------------

Ultimately, if such issues are not resolved in a timely manner, our cash flows could be impaired and our ability to reach profitability could be limited.

We may encounter problems or delays in processing tests or in expanding our automated testing systems, which could impair our ability to grow our
business, generate revenue and achieve and sustain profitability.

In order to meet future projected demand for our products and fully
utilize our current clinical laboratory facilities, we may have to expand the volume of patient samples that we are able to process. We will also need to incorporate theeTag assays into our laboratory processes. We will also need to
continue to develop our quality-control procedures and to establish more consistency with respect to test turnaround so that results are delivered in a timely manner. Thus, we will need to continue to develop and implement additional automated
systems to perform our tests. We have installed laboratory information systems over the past few years to support the automated tests, analyze the data generated by our tests and report the results. If these systems do not work effectively as we
scale up our processing of patient samples, we may experience processing or quality-control problems and may experience delays or failures in our operations. These problems, delays or failures could adversely impact the promptness and accuracy of
our transaction processing, which could impair our ability to grow our business, generate revenue and achieve and sustain profitability. We have experienced periods during which processing of our test results was delayed and periods during which the
proportion of samples for which results could not be generated were higher than expected. While we are continuing to attempt to minimize the likelihood of any recurrence of these issues, future delays, processing problems and backlog may
nevertheless occur, resulting in the loss of our customers and/or revenue and an adverse effect on our results of operations.

We face intense
competition, and if our competitors existing products or new products are more effective than our products, the commercial opportunity for our products will be reduced or eliminated.

The commercial opportunity for our products will be reduced or eliminated if our competitors develop and market new testing products that are superior to,
or are less expensive than, the testing products that we develop using our proprietary technology. The biotechnology industry evolves at a rapid pace and is highly competitive. Our competitors for our HIV resistance testing products include
manufacturers and distributors of phenotypic and genotypic drug resistance technology, such as Tibotec-Virco, a division of Johnson & Johnson, Specialty Laboratories, Applied Biosystems Group, Visible Genetics, a division of Siemens,
Viralliance, and reference and academic laboratories. For our Trofile Co-Receptor Tropism Assay, we are not aware of any other products currently available for this application. However, we are aware of efforts by third parties to develop
competitive assays using phenotypic and genotypic approaches. We believe genotypic approaches to the identification of tropism are thought to be significantly less precise than our phenotypic approach. However, we cannot be assured that simpler,
less expensive tropism tests will not be developed and commercialized.

We also compete with companies that are developing alternative
technological approaches for patient testing in the cancer field. There are likely to be many competitive companies and many technological approaches in the emerging field of testing for likely responsiveness to the new class of targeted cancer
therapies,



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including companies such as DakoCytomation A/S, Genzyme and Abbott Laboratories that currently commercialize testing products for guiding therapy of cancer
patients. Established diagnostic product companies such as Abbott Laboratories, Roche Diagnostics and Bayer Diagnostics and established clinical laboratories such as Quest Diagnostics and Laboratory Corporation of American may also develop or
commercialize services or products that are competitive with those that we anticipate developing and commercializing. In addition, there are a number of alternative technological approaches being developed by competitors. In particular, while our
anticipated oncology testing products will be based on the identification of protein-based differences among patients, there is significant interest in the oncology community in gene-based approaches that may be available from other companies, which
may prove to be a superior technology to ours.

Each of these competitors is attempting to establish its own test as the standard of care.
Our competitors may successfully develop and market other testing products that are either superior to those that we may develop or that are marketed prior to marketing of our testing products. One or more of our competitors may render our
technology obsolete or uneconomical by advances in existing technological approaches or the development of different approaches. Some of these competitors have substantially greater financial resources, market presence and research and development
staffs than we do. In addition, some of these competitors have significantly greater experience in developing products, and in obtaining the necessary regulatory approvals of products and processing and marketing products.

Various testing materials that we use are purchased from single qualified suppliers, which could result in our inability to secure sufficient materials to conduct our
business.

We purchase some of the testing materials used in our laboratory operations from single qualified suppliers. Although these
materials could be purchased from other suppliers, we would need to qualify the suppliers prior to using their materials in our commercial operations. Although we believe we have ample inventory to allow validation of another source, in the event of
a material interruption of these supplies, the quantity of our inventory may not be adequate.

Any extended interruption, delay or
decreased availability of the supply of these testing materials could prevent us from running our business as contemplated and result in failure to meet our customers demands. If significant customer relationships were harmed by our failure to
meet customer demands, our revenues may decrease. We might also face significant additional expenses if we are forced to find alternate sources of supplies, or change materials we use. Such expenses could make it more difficult for us to attain
profitability, offer our products at competitive prices and continue our business as currently contemplated or at all.

We may be dependent on licenses
for technology we use in our testing products, and our business would suffer if these licenses were terminated or were not available.

Historically, we have licensed technology from Roche Applied Science Division of Roche Diagnostics Corporation, (Roche), that we use in our PhenoSense and GeneSeq tests. We held a non-exclusive license for the life of the patent
term of the last licensed Roche patent. We were notified by Roche that the license had terminated in March 2005 because the last licensed patent had expired. However, Roche advised us that additional licenses may be necessary for certain other
patents and has offered us a license to these patents. We are in the process of reviewing whether additional licenses are necessary or useful for our operations. We believe such licenses are available on commercially acceptable terms.

As we develop and begin to commercialize our testing products in oncology, we may encounter the need for licenses to technology owned by others in order
to commercialize these products. If such licenses become necessary, there is no guarantee that they will be available on commercially acceptable terms.



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The intellectual property protection for our technology and trade secrets may not be adequate, allowing third parties
to use our technology or similar technologies, and thus reducing our ability to compete in the market.

The strength of our intellectual
property protection is uncertain. In particular, we cannot be sure that:



| |  |  | we were the first to invent the technologies covered by our patents or pending patent applications;
| | - |  | ---------------------------------------------------------------------------------------------------



| |  |  | we were the first to file patent applications for these inventions;
| | - |  | -------------------------------------------------------------------



| |  |  | others will not independently develop similar or alternative technologies or duplicate any of our technologies;
| | - |  | ---------------------------------------------------------------------------------------------------------------



| |  |  | any of our pending patent applications will result in issued patents; or
| | - |  | ------------------------------------------------------------------------



| |  |  | any patents issued to us will provide a basis for commercially viable products or will provide us with any competitive advantages or will not be challenged by third
parties.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------

With respect to our viral disease portfolio, as of December 31, 2006 we have approximately 98 granted,
issued, allowed, and pending patent applications in the United States and in other countries, including 45 issued patents. With respect to our potential oncology products and eTag technology, we currently have approximately 57 granted,
issued, allowed, and pending patent applications in the United States and in other countries, including 20 issued patents. We have 110 granted, issued, allowed, and pending patent applications in the United States and in other countries, including
87 issued or allowed patents, relating to the historic microfluidics business of ACLARA. We had licensed certain patents under the Roche license discussed above. These patents covered a broad range of technology applicable across our entire current
and planned product line.

Other companies may have patents or patent applications relating to products or processes similar to,
competitive with or otherwise related to our current and planned products. Patent law relating to the scope of claims in the technology fields in which we operate, including biotechnology and information technology, is still evolving and,
consequently, patent positions in these industries are generally uncertain. We will not be able to assure you that we will prevail in any lawsuits regarding the enforcement of patent rights or that, if successful, we will be awarded commercially
valuable remedies. In addition, it is possible that we will not have the required resources to pursue offensive litigation or to otherwise protect our patent rights.

In addition to patent protection, we also rely on protection of trade secrets, know-how and confidential and proprietary information. We generally enter into confidentiality agreements with our employees, consultants
and their collaborative partners upon commencement of a relationship with them. However, we cannot assure you that these agreements will provide meaningful protection against the unauthorized use or disclosure of our trade secrets or other
confidential information or that adequate remedies would exist if unauthorized use or disclosure were to occur. The unintended disclosure of our trade secrets and other proprietary information would impair our competitive advantages and could have a
material adverse effect on our operating results, financial condition and future growth prospects. Further, we cannot assure you that others have not or will not independently develop substantially equivalent know-how and technology.

In addition, there is a risk that some of our confidential information could be compromised during the discovery process of any litigation. During the
course of any lawsuit, there may be public announcements of the results of hearings, motions and other interim proceedings or developments in the litigation. If securities analysts or investors perceive these results to be negative, it could have a
substantial negative effect on the trading price of our common stock.

Our products could infringe on the intellectual property rights of others, which
may cause us to engage in costly litigation and, if we are not successful defending any such litigation or cannot obtain necessary licenses, we may have to pay substantial damages and/or be prohibited from selling our products.

Our commercial success depends upon our ability to develop, manufacture, market and sell our products and use our proprietary technologies without
infringing the proprietary rights of others. Companies in our industry



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typically receive a higher than average number of claims and threatened claims of infringement of intellectual property rights. Numerous U.S. and foreign
issued patents and pending patent applications owned by others exist in the fields in which we are selling and/or developing or expect to sell and/or develop products. We may be exposed to future litigation by third parties based on claims that our
products, technologies or activities infringe the intellectual property rights of others. Because patent applications can take many years to issue, there may be currently pending applications, unknown to us, which may later result in issued patents
that our products or technologies may infringe. There also may be existing patents, of which we are not aware, that our products or technologies may inadvertently infringe. Further, there may be issued patents and pending patent applications in
fields relevant to our business, of which we may become aware from time to time, that we believe we do not infringe or that we believe are invalid or relate to immaterial portions of our overall business. We will not be able to assure you that third
parties holding any of these patents or patent applications will not assert infringement claims against us for damages or seeking to enjoin our activities. We will also not be able to assure you that, in the event of litigation, we will be able to
successfully assert any belief we may have as to non-infringement, invalidity or immateriality, or that any infringement claims will be resolved in our favor. Third parties have from time to time threatened to assert infringement or other
intellectual property claims against us based on our patents or other intellectual property rights or informed us that they believe we required one or more licenses in order to perform certain of our tests. For instance, we have been informed by
Bayer Diagnostics, or Bayer, that it believes we require one or more licenses to patents controlled by Bayer in order to conduct certain of our current and planned operations and activities. We, in turn, believe that Bayer may require one or more
licenses to patents controlled by us. Although we believe we do not need a license from Bayer for our HIV products, we have had discussions with Bayer concerning the possibility of entering into a cross-licensing or other arrangement, and believe
that if necessary, licenses from Bayer would be available to us on commercially acceptable terms. However, in the future, we may have to pay substantial damages, possibly including treble damages, for infringement if it is ultimately determined that
our products infringe a third partys patents. Further, we may be prohibited from selling our products before we obtain a license, which, if available at all, may require us to pay substantial royalties. Even if infringement claims against us
are without merit, defending a lawsuit will take significant time, and may be expensive and divert management attention from other business concerns.

Our business operations and the operation of our clinical laboratory facility are subject to stringent regulations and if we are unable to comply with them, we may be prohibited from accepting patient samples or may incur additional
expense to attain and maintain compliance, which would have an adverse impact on our revenue and profitability.

The operation of our
clinical laboratory facilities is subject to a stringent level of regulation under the Clinical Laboratory Improvement Amendments of 1988. Laboratories must meet various requirements, including requirements relating to quality assurance, quality
control and personnel standards. Our laboratories are also subject to regulations by the State of California and various other states. We have received accreditation by the College of American Pathologists and therefore are subject to their
requirements and evaluation. Our failure to comply with applicable requirements could result in various penalties, including loss of certification or accreditation, and we may be prevented from conducting our business as we currently do or as we may
wish to in the future.

If we do not comply with laws and regulations governing the confidentiality of medical information, we may lose the state
licensure we need to operate our business, and may be subject to civil, criminal or other penalties. Compliance with such laws and regulations could be expensive.

The Department of Human Health and Services, or HHS, has issued final regulations under the Health Insurance Portability and Accountability Act of 1996, or HIPAA, designed to improve the efficiency and effectiveness
of the health care system by facilitating the electronic exchange of information in certain financial and administrative transactions, while protecting the privacy and security of the information exchanged. Three principal regulations have been
issued:



| |  |  | privacy regulations;
| | - |  | --------------------



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| |  |  | security regulations; and
| | - |  | -------------------------



| |  |  | standards for electronic transactions, or transaction standards.
| | - |  | ----------------------------------------------------------------

We have implemented the HIPAA privacy regulations. In addition, we implemented measures we believe will reasonably and appropriately meet the specifications of the security regulations and the transaction standards.

These standards are complex, and subject to differences in interpretation. We will not be able to guarantee that our compliance measures
will meet the specifications for any of these regulations. In addition, certain types of information, including demographic information not usually provided to us by physicians, could be required by certain payors. As a result of inconsistent
application of requirements by payors, or our inability to obtain billing information, we could face increased costs and complexity, a temporary disruption in receipts and ongoing reductions in reimbursements and net revenues. We cannot estimate the
potential impact of payors implementing (or failing to implement) the HIPAA transaction standards on our cash flows and results of operations.

In addition to the HIPAA provisions described above, there are a number of state laws regarding the confidentiality of medical information, some of which apply to clinical laboratories. These laws vary widely, and new laws in this area are
pending, but they most commonly restrict the use and disclosure of medical information without patient consent. Penalties for violation of these laws include sanctions against a laboratorys state licensure, as well as civil and/or criminal
penalties. Compliance with such rules could require us to spend substantial sums, which could negatively impact our profitability.

We may be unable to
build brand loyalty because our trademarks and trade names may not be protected. We may not be able to build brand loyalty in the new markets that we are entering and may enter in the future.

Our registered or unregistered trademarks or trade names such as the names PhenoSense, PhenoSense GT, PhenoScreen, GeneSeq, Trofile andeTag may be
challenged, canceled, infringed, circumvented or declared generic or determined to be infringing on other marks. We may not be able to protect our rights to these trademarks and trade names, which we need to build brand loyalty. Brand recognition is
critical to our short-term and long-term marketing strategies especially as we commercialize future enhancements to our products. In particular as we broaden our commercial focus from viral diseases to oncology and other serious diseases, we may not
be able to establish any brand recognition and loyalty in oncology and other new markets that we may enter in the future.

We may be unable to identify
and lease additional or replacement facilities at a reasonable cost in close proximity to our existing facilities. Our costs could increase and our ability to coordinate our operations could be seriously impaired as a result of inefficient location
of facilities.

Our sublease on a facility in South San Francisco of approximately 27,000 square feet expires at the end of December
2007 and we will need to identify an alternative facility in reasonable proximity to our second building in South San Francisco, in which our clinical laboratory is located and for which the lease expires in 2010. The availability of facilities in
South San Francisco is severely limited and there is no guarantee that we will be able to identify suitable space at a commercially reasonable cost. In addition, alternative facilities may not be in close proximity to our existing facilities and
this could cause disruption and inefficiencies in our operations.

Due to increased market lease rates, the potential cost of moving to a
new facility and the cost of leasehold improvements and equipment in an alternative facility, our capital and operating costs could increase substantially in connection with our leasing of additional or replacement facilities.



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Clinicians or patients using our products or services may sue us and our insurance may not sufficiently cover all
claims brought against us, which would increase our expenses.

Clinicians, patients and others may at times seek damages from us if
drugs are incorrectly prescribed for a patient based on testing errors or similar claims. Although we have obtained product liability insurance coverage of up to $6 million, and expect to continue to maintain product liability insurance coverage, we
will not be able to guarantee that insurance will continue to be available to us on acceptable terms or that our coverage will be sufficient to protect us against all claims that may be brought against us. We may not be able to maintain our current
coverage, or obtain new insurance coverage for our planned future testing services and products, such as planned testing service and kits for use in connection with the treatment of cancer patients, on acceptable terms with adequate coverage, or at
reasonable costs. We may incur significant legal defense expenses in connection with a liability claim, even one without merit or for which we have coverage.

We may be subject to litigation, which would be time consuming and divert our resources and the attention of our management.

ACLARA, with which we merged in December 2004, and certain of its former officers and directors, referred to together as the ACLARA defendants, are named as defendants in a securities class action lawsuit filed in the United States District
Court for the Southern District of New York. This action, which was filed on November 13, 2001 and is now captioned ACLARA BioSciences, Inc. Initial Public Offering Securities Litigation, also names several of the underwriters involved in
ACLARAs initial public offering, or IPO, as defendants. This class action is brought on behalf of a purported class of purchasers of ACLARA common stock from the time of ACLARAs March 20, 2000 IPO through December 6, 2000. The
central allegation in this action is that the underwriters in the ACLARA IPO solicited and received undisclosed commissions from, and entered into undisclosed arrangements with, certain investors who purchased ACLARA stock in the IPO and the
after-market. The complaint also alleges that the ACLARA defendants violated the federal securities laws by failing to disclose in the IPO prospectus that the underwriters had engaged in these allegedly undisclosed arrangements. More than 300
issuers who went public between 1998 and 2000 have been named in similar lawsuits. In July 2002, an omnibus motion to dismiss all complaints against issuers and individual defendants affiliated with issuers (including ACLARA defendants) was filed by
the entire group of issuer defendants in these similar actions. On February 19, 2003, the Court in this action issued its decision on the defendants omnibus motion to dismiss. This decision dismissed the Section 10(b) claim as to
ACLARA but denied the motion to dismiss Section 11 claim as to ACLARA and virtually all of the other defendants. On June 26, 2003, the plaintiffs in the consolidated class action lawsuits announced a proposed settlement with ACLARA and the
other issuer defendants. The proposed settlement, which was approved by ACLARAs board of directors, provides that the insurers of all settling issuers will guarantee that the plaintiffs recover $1 billion from non-settling defendants,
including the investment banks who acted as underwriters in those offerings. In the event that the plaintiffs do not recover $1 billion, the insurers for the settling issuers will make up the difference. Under the proposed settlement, the maximum
amount that could be charged to ACLARAs insurance policy in the event that the plaintiffs recovered nothing from the investment banks would be approximately $3.9 million. We believe that ACLARA had sufficient insurance coverage to cover the
maximum amount that we may be responsible for under the proposed settlement. On August 31, 2005, the Court granted unconditional preliminary approval of the proposed settlement. On April 24, 2006, the Federal District Court held a fairness
hearing to determine whether the proposed settlement should be approved. The Court has not yet decided whether to approve the settlement. On December 5, 2006, the United States Court of Appeals for the 2nd Circuit issued a decision
re: Initial Public Offering Securities Litigation (Docket No. 05-3349-cv), reversing the Federal District Courts finding that six focus cases involved in this litigation could be certified as class actions. It is not yet clear what
impact, if any, the decision may have on the proposed settlement agreement. Plaintiffs have filed a petition for rehearing and/or for en banc review of the Second Circuits decision and the Federal District Court has indicated it will not make
any decision regarding the proposed settlement agreement until the Second Circuit decides whether it will consider a rehearing. On January 24, 2007, the Second Circuit ordered Underwriters to file a response on certain issues to
Plaintiffs request for a rehearing. Due to the inherent uncertainties of

litigation and assignment of claims against the underwriters, and because
the settlement has not yet been finally



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approved by the Federal District Court, the ultimate outcome of the matter cannot be predicted. If a final settlement is not reached or is not approved by
the court, we believe that we have meritorious defenses and intend to vigorously defend against the suit. As a result of this belief, no liability for this suit has been recorded in the accompanying financial statements. However, we could be forced
to incur significant expenses in the litigation, and in the event there is an adverse outcome, our business could be harmed.

Our operating results may
fluctuate from quarter to quarter, making it likely that, in some future quarter or quarters, we will fail to meet estimates of operating results or financial performance, causing our stock price to fall.

If revenue declines in a quarter, our losses will likely increase or our earnings will likely decline because many of our expenses are relatively fixed.
Though our revenues may fluctuate significantly as we continue to build the market for our products, expenses such as research and development, sales and marketing and general and administrative are not affected directly by variations in revenue.
The cost of our product revenue could also fluctuate significantly due to variations in the demand for our products and the relatively fixed costs to produce them. In addition, we could experience significant fluctuations in our statement of
operations for stock-based compensation. We will not be able to accurately predict how volatile our future operating results will be because our past and present operating results, which reflect moderate sales activity, are not indicative of what we
might expect in the future. As a result it will be very difficult for us to forecast our revenues accurately and it is likely that in some future quarter or quarters, our operating results will be below the expectations of securities analysts or
investors. In this event, the market price of our common stock may fall abruptly and significantly. Because our revenue and operating results will be difficult to predict, period-to-period comparisons of our results of operations may not be a good
indication of our future performance.

In the event that we need to raise additional capital, our stockholders could experience substantial additional
dilution. If such financing is not available on commercially reasonable terms, we may have to significantly curtail our operations or sell significant assets and may be unable to continue as a going concern.

We anticipate that our capital resources, together with funds from the sale of our products, contract revenue and borrowing under equipment and accounts
receivable financing arrangements, will enable us to maintain our current research and development, marketing, production and general administrative activities related to HIV drug resistance in the United States, together with the development and
initial commercialization of theeTag technology, at least for the next twelve months. The commercialization of theeTag technology is expected to include the development of a testing service and possibly test kits for use in
connection with the treatment of cancer patients. However, we may need additional funding to accomplish these goals. To the extent operating and capital resources are insufficient to meet our obligations, including lease payments and future
requirements, we will have to raise additional funds to continue the development, commercialization and expansion of our technologies, including theeTag technology and products based on that technology. Our inability to raise capital would
seriously harm our business and product development efforts. In addition, we may choose to raise additional capital due to market conditions or strategic considerations even if we believe we have sufficient funds for our current or future operating
plans. However, we cannot guarantee that additional financing, in any form, will be available at all, or on terms acceptable to us. If we sell equity or convertible debt securities to raise additional funds, our existing stockholders may incur
substantial dilution and any shares so issued will likely have rights, preferences and privileges superior to the rights, preferences and privileges of our outstanding common stock. In the event financing is not available in the time frame required,
we could be forced to reduce our operating expenses, curtail sales and marketing activities, reschedule research and development projects or delay, scale back or eliminate some or all of our activities. Further, we might be required to sell certain
of our assets or obtain funds through arrangements with third parties that require us to relinquish rights to certain of our technologies or products that we would seek to develop or commercialize on our own. These actions, while necessary for the
continuance of operations during a time of cash constraints and a shortage of working capital, could make it difficult or impossible to implement our long-term business plans or could affect our ability to continue as a going concern.



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If a natural disaster strikes our clinical laboratory facilities and we are unable to receive and or process our
customers samples for a substantial amount of time, we would lose revenue.

We rely on a single clinical laboratory facility to
process patient samples for our tests, which are received via delivery service or mail, and have no alternative facilities. We will also use this facility for conducting other tests we develop, includingeTag assays, and even if we move into
different or additional facilities they will likely be in close proximity to our current clinical laboratory. Our clinical laboratories and some pieces of processing equipment are difficult to replace and could require substantial replacement
lead-time. Our facilities may be affected by natural disasters such as earthquakes and floods. Earthquakes are of particular significance because our facilities are located in the San Francisco Bay Area, an earthquake-prone area, and we do not have
insurance against earthquake loss. Our insurance coverage, if any, may not be adequate to cover total losses incurred in a natural disaster. However, even if covered by insurance, in the event our clinical laboratory facilities or equipment is
affected by natural disasters, we would be unable to process patient samples and meet customer demands or sales projections. If our patient sample processing operations were curtailed or ceased, we would not be able to perform tests, which would
reduce our revenues, and may cause us to lose the trust of our customers or market share.

We use hazardous chemicals and biological materials in our
business, and any claims relating to any alleged improper handling, storage, use or disposal of these materials could adversely harm our business.

Our research and development and manufacturing processes involve the use of hazardous materials, including chemicals and biological materials. Our operations also produce hazardous waste products. We will not be able
to eliminate the risk of accidental contamination or discharge and any resultant injury from these materials. Federal, state and local laws and regulations govern the use, manufacture, storage, handling and disposal of these materials. We do not
maintain insurance coverage for damage caused by accidental release of hazardous chemicals, or exposure of individuals to hazardous chemicals off of our premises. We could be subject to damages in the event of an improper or unauthorized release of,
or exposure of individuals to, hazardous materials. In addition, claimants may sue us for injury or contamination that results from our use, or the use by third parties, of these materials, and our liability under a claim of this nature may exceed
our total assets. Compliance with environmental laws and regulations is expensive, and current or future environmental regulations may impair our research, development or production efforts.

Concentration of ownership among some of our stockholders may prevent other stockholders from influencing significant corporate decisions.

As of March 1, 2007, approximately 50% of our common stock is beneficially held by our directors, our executive officers, and greater than five
percent stockholders. The most significant of these stockholders in terms of beneficial ownership are Perry Corp., Federated Investors, Inc., Stephens Investment Management, Inc., Kenneth F. Siebel and Pfizer. Consequently, a small number of our
stockholders may be able to substantially influence our management and affairs. If acting together, they would be able to influence most matters requiring the approval by our stockholders, including the election of directors, any merger,
consolidation or sale of all or substantially all of our assets and any other significant corporate transaction. The concentration of ownership may also delay or prevent a change in control of Monogram Biosciences at a premium price if these
stockholders oppose it.

If our stockholders or convertible note holders sell substantial amounts of our common stock, the market price of our common
stock may fall.

If our stockholders or convertible note holders sell substantial amounts of our common stock, including shares issued
upon the exercise of outstanding options, or conversion of our outstanding convertible debt, the market price of our common stock may fall. As of December 31, 2006 we had outstanding options under our employee stock options plan to purchase
19.2 million shares of our common stock, which represents approximately 15% of our common stock outstanding on December 31, 2006, at a weighted-average price of $2.39 per share. Our outstanding convertible notes are convertible at the
option of the holders into shares of our



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common stock. We intend to register the 0% Senior Unsecured Convertible Notes and the shares of common stock issuable upon conversion of these Notes with the
SEC. We have also registered the shares issuable upon conversion of the Pfizer Note. Accordingly, the common stock issued upon conversion of the Notes and the Pfizer Note will be freely tradable in the public markets without restriction. The
conversion of these notes into common stock could result in the issuance of a substantial number of shares and substantial dilution to our stockholders. Sales of substantial amounts of our common stock, including hedging activities by our
convertible note holders, or the perception that such sales could occur, whether currently outstanding, or issued as the result of option exercises or conversion of convertible debt, might also make it more difficult for us to sell equity or
equity-related securities in the future at a time and price that we deem appropriate. Sales of a substantial number of shares could occur at any time. This may decrease the price of our common stock and the Notes and may impair our ability to raise
capital in the future.

Provisions of our charter documents and Delaware law may make it difficult for our stockholders to replace our management and
may inhibit a takeover, either of which could limit the price investors might be willing to pay in the future for our common stock.

Provisions in our certificate of incorporation and bylaws may make it difficult for our stockholders to replace or remove our management, and may delay or prevent an acquisition or merger in which we are not the surviving company. In
particular:



| |  |  | Our board of directors is classified into three classes, with only one of the three classes elected each year, so that it would take at least two years to replace a
majority of our directors;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Our bylaws contain advance notice provisions that limit the business that may be brought at an annual meeting and place procedural restrictions on the ability to
nominate directors; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Our common stockholders are not permitted to call special meetings or act by written consent.
| | - |  | ---------------------------------------------------------------------------------------------

Because we are incorporated in Delaware, we are governed by the provisions of Section 203 of the Delaware General Corporation Law. These provisions
could discourage changes of our management and acquisitions or other changes in our control and otherwise limit the price that investors might be willing to pay in the future for our common stock.

We could adopt a stockholder rights plan, commonly referred to as a poison pill, at any time without seeking the approval of our
stockholders. Stockholder rights plans can act through a variety of mechanisms, but typically would allow our board of directors to declare a dividend distribution of preferred share purchase rights on outstanding shares of our common stock. Each
such share purchase right would entitle our stockholders to buy a newly created series of preferred stock in the event that the purchase rights become exercisable. The rights would typically become exercisable if a person or group acquires over a
predetermined portion of our common stock or announces a tender offer for more than a predetermined portion of our common stock. Under such a stockholder rights plan, if we were acquired in a merger or other business combination transaction which
had not been approved by our board of directors, each right would entitle its holder to purchase, at the rights then-current exercise price, a number of the acquiring companys common shares at a price that is preferential to the holder
of the right. If adopted by the our board of directors, a stockholder rights plan may have the effect of making it more difficult for a third party to acquire, or discourage a third party from attempting to acquire, control of us.

Our stock price may be volatile, and our common stock could decline in value.

The market prices for securities of biotechnology companies in general have been highly volatile and may continue to be highly volatile in the future. Our stock price has fluctuated widely during the last few years
from a low of $0.72 per share in September 2002 to a high of $4.40 per share in January 2004. The following factors, in addition to other risk factors described in this section, may have a significant negative impact on the market price of our
common stock:



| |  |  | period-to-period fluctuations in financial results;
| | - |  | ---------------------------------------------------



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| |  |  | financing activities;
| | - |  | ---------------------



| |  |  | hedging activities by holders of our convertible notes;
| | - |  | -------------------------------------------------------



| |  |  | litigation;
| | - |  | -----------



| |  |  | delays in product introduction, launches or enhancements, including delays in completing the development of theeTag technology and products based on that
technology;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | announcements of technological innovations or new commercial products by our competitors;
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | results from clinical studies;
| | - |  | ------------------------------



| |  |  | adverse developments in the clinical trials of drugs under development by our pharmaceutical company customers;
| | - |  | ---------------------------------------------------------------------------------------------------------------



| |  |  | adverse clinical or regulatory developments related to drugs, such as Pfizers maraviroc, for which our tests are used in patient selection or
monitoring;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | developments concerning proprietary rights, including patents;
| | - |  | --------------------------------------------------------------



| |  |  | publicity regarding actual or potential clinical results relating to products under development by our competitors or our own products or products under
development;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | regulatory developments in the United States and foreign countries;
| | - |  | -------------------------------------------------------------------



| |  |  | changes in payor reimbursement policies;
| | - |  | ----------------------------------------



| |  |  | limitations on the ability to recognize revenue from complex collaborations; and
| | - |  | --------------------------------------------------------------------------------



| |  |  | economic and other external factors or other disaster or crisis.
| | - |  | ----------------------------------------------------------------

A low or volatile stock price may negatively impact our ability to raise capital and to attract and maintain key employees.

Item 1B.Unresolved Staff Comments

None.

Item 2.Properties

As of March 2, 2007, we leased a building of approximately 41,000
square feet in South San Francisco, California, comprising laboratory and office space. The lease expires in April 2010 and provides an option to extend the term for an additional ten years. We also subleased approximately 27,000 square feet in
another adjacent building in South San Francisco, California, comprising laboratory and office space. This sublease expires in December 2007. In February 2007, we entered into a twelve month lease on approximately 9,000 square feet of office space
in South San Francisco.

In addition, as a result of our merger with ACLARA, we assumed the lease for a building of approximately 44,200
square feet in Mountain View, California comprising laboratory and office space. On February 7, 2007, we entered into a lease termination agreement with the landlord to terminate the lease prior to its scheduled expiry. See Subsequent
Events Note 14 to the financial statements included in this Annual Report on Form 10-K for further discussion.

Item 3.Legal Proceedings

ACLARA, with which we merged, and certain of its former officers
and directors, referred to together as the ACLARA defendants, are named as defendants in a securities class action lawsuit filed in the United States District Court for the Southern District of New York. See Commitments and Contingencies
Note 8 to the financial statements for further discussion.



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##### Table of Contents

Item 4.Submission of Matters to a Vote of Security Holders

We held the Annual Meeting of
Stockholders on December 6, 2006, and two matters were voted upon. A description of each matter and tabulation of votes are as follows:



|1. | Two Class III directors were elected to our board to hold office until the 2009 Annual Meeting of Stockholders, or until their successors are elected and qualified. The nominees and
the voting for each were as follows:
|-- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|                  |  |            
|----------------- |  | -----------
|Thomas R. Baruch: |  |            
|For               |  | 121,252,843
|Withheld          |  | 802,880    
|David H. Persing: |  |            
|For               |  | 120,087,673
|Withheld          |  | 1,968,050  

The following directors terms of office continued after the Annual Meeting of Stockholders
on December 6, 2006:

Edmon R. Jennings

William Jenkins

Cristina H. Kepner

John D. Mendlein

William D. Young



|2. | The appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2006 was ratified.
|-- | -------------------------------------------------------------------------------------------------------------------------------------------------------------

The voting for the proposal was as follows:



|        |  |            
|------- |  | -----------
|For     |  | 121,877,280
|Against |  | 144,928    
|Abstain |  | 33,514     



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##### Table of Contents

PART II



|Item 5. | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities
|------- | ------------------------------------------------------------------------------------------------------------

(a) Market Data; Dividends

Our
Common Stock trades on the Nasdaq National Market under the symbol MGRM. The following table sets forth, for the periods indicated, the high and low sales prices of our common stock on the Nasdaq National Market:



|               |  |      |      |     |   |     
|-------------- |  | ---- | ---- | --- | - | ----
|               |  | High |      | Low
|2006           |  |      |      |     |   |     
|Fourth Quarter |  | $    | 1.98 |     | $ | 1.48
|Third Quarter  |  | $    | 1.95 |     | $ | 1.30
|Second Quarter |  | $    | 2.42 |     | $ | 1.33
|First Quarter  |  | $    | 2.27 |     | $ | 1.69
|               |  |     
|2005           |  |      |      |     |   |     
|Fourth Quarter |  | $    | 2.40 |     | $ | 1.33
|Third Quarter  |  | $    | 2.73 |     | $ | 2.26
|Second Quarter |  | $    | 2.95 |     | $ | 2.33
|First Quarter  |  | $    | 2.81 |     | $ | 2.15

The last reported sale price of our common stock on the Nasdaq National Market on March 5,
2007 was $1.86. As of March 5, 2007, there were approximately 300 stockholders of record of our common stock.

We have never declared
or paid any cash dividends on our common stock. We currently intend to retain any future earnings for funding growth and, therefore, do not anticipate paying any cash dividends on our common stock in the foreseeable future. Any future determination
to pay cash dividends on our common stock will be at the discretion of the board of directors and will be dependent upon our financial condition, results of operations, capital requirements, restrictions under our agreements and other such factors
as the board of directors deems relevant. Additionally, under our Loan and Security Agreement with Merrill Lynch Capital, so long as any loan commitment or obligation remains outstanding under the agreement, we cannot pay cash dividends without the
consent of Merrill. Under our Amended and Restated 3% Senior Secured Convertible Note issued to Pfizer, we cannot pay dividends without the consent of Pfizer Inc.

Recent Sales of Unregistered Securities.

None.

Equity Compensation Plans

Information about our equity compensation plans is included in
Item 12 of Part III of this Annual Report.



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##### Table of Contents

Item 6.Selected Financial Data

The following selected financial information is not
necessarily indicative of results of future operations, and should be read in conjunction with Item 7, Managements Discussion and Analysis of Financial Condition and Results of Operations and the financial statements and
related notes thereto included in Item 8 of this Annual Report on Form 10-K in order to fully understand factors that may affect the comparability of the information presented below. The statements of operations data for the years ended
December 31, 2006, 2005 and 2004 and the balance sheet data as of December 31, 2006 and 2005 are derived from our audited financial statements included in Item 8 of this Report. The statements of operations data for the years ended
December 31, 2003 and 2002 and the balance sheet data as of December 31, 2004, 2003 and 2002 are derived from our audited financial statements not included in this Report.



|                                                                 |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  
|---------------------------------------------------------------- |  | ---------------------------------------- | ------- | - | ---- | - | ------- | ---- |  | - | -------- | - |  | ---- | ------ | - |  | - | ------- | -
|                                                                 |  | Year Ended December 31,                  |        
|                                                                 |  | 2006                                     |         |   | 2005 |   |         | 2004 |  |   | 2003     |   |  | 2002 |       
|                                                                 |  | (In thousands, except per share amounts) |        
|                                                                 |  | (Unaudited)                              |        
|Statement of Operations Data:                                    |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  
|Revenue:                                                         |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  
|Product revenue                                                  |  | $                                        | 45,150  |   |      | $ | 43,468  |      |  | $ | 34,811   |   |  | $    | 31,911 |   |  | $ | 24,530  |  
|Contract revenue                                                 |  |                                          | 2,808   |   |      |   | 4,784   |      |  |   | 1,990    |   |  |      | 1,468  |   |  |   | 731     |  
|                                                                 |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  
|Total revenue                                                    |  |                                          | 47,958  |   |      |   | 48,252  |      |  |   | 36,801   |   |  |      | 33,379 |   |  |   | 25,261  |  
|Operating costs and expenses:                                    |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  
|Cost of product revenue                                          |  |                                          | 22,703  |   |      |   | 20,001  |      |  |   | 17,794   |   |  |      | 16,713 |   |  |   | 14,589  |  
|Research and development                                         |  |                                          | 18,981  |   |      |   | 18,996  |      |  |   | 7,839    |   |  |      | 4,733  |   |  |   | 10,406  |  
|Purchased in-process research and development charge             |  |                                          |        |   |      |   |        |      |  |   | 100,600  |   |  |      |       |   |  |   |        |  
|Sales and marketing                                              |  |                                          | 14,735  |   |      |   | 12,588  |      |  |   | 10,056   |   |  |      | 8,306  |   |  |   | 11,716  |  
|General and administrative                                       |  |                                          | 15,042  |   |      |   | 10,200  |      |  |   | 10,192   |   |  |      | 9,256  |   |  |   | 10,550  |  
|Lease termination charge                                         |  |                                          |        |   |      |   |        |      |  |   | 433      |   |  |      |       |   |  |   |        |  
|                                                                 |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  
|Total operating costs and expenses                               |  |                                          | 71,461  |   |      |   | 61,785  |      |  |   | 146,914  |   |  |      | 39,008 |   |  |   | 47,261  |  
|                                                                 |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  
|Operating loss                                                   |  |                                          | (23,503 | ) |      |   | (13,533 | )    |  |   | (110,113 | ) |  |      | (5,629 | ) |  |   | (22,000 | )
|Interest income                                                  |  |                                          | 1,874   |   |      |   | 2,303   |      |  |   | 198      |   |  |      | 106    |   |  |   | 307     |  
|Interest expense                                                 |  |                                          | (624    | ) |      |   | (60     | )    |  |   | (34      | ) |  |      | (141   | ) |  |   | (423    | )
|Contingent value rights revaluation                              |  |                                          | (16,450 | ) |      |   | (26,296 | )    |  |   | 28,519   |   |  |      |       |   |  |   |        |  
|Other income                                                     |  |                                          |        |   |      |   |        |      |  |   |         |   |  |      | 156    |   |  |   | 347     |  
|                                                                 |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  
|Net loss                                                         |  |                                          | (38,703 | ) |      |   | (37,586 | )    |  |   | (81,430  | ) |  |      | (5,508 | ) |  |   | (21,769 | )
|Deemed dividend to preferred stockholders                        |  |                                          |        |   |      |   |        |      |  |   |         |   |  |      | (2,155 | ) |  |   | (10,551 | )
|Preferred stock dividend                                         |  |                                          |        |   |      |   | (162    | )    |  |   | (324     | ) |  |      | (1,610 | ) |  |   | (977    | )
|                                                                 |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  
|Loss applicable to common stockholders                           |  | $                                        | (38,703 | ) |      | $ | (37,748 | )    |  | $ | (81,754  | ) |  | $    | (9,273 | ) |  | $ | (33,297 | )
|                                                                 |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  
|Basic and diluted net loss per common share                      |  | $                                        | (0.30   | ) |      | $ | (0.31   | )    |  | $ | (1.43    | ) |  | $    | (0.27  | ) |  | $ | (1.38   | )
|                                                                 |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  
|Shares used in computing basic and diluted loss per common share |  |                                          | 130,447 |   |      |   | 123,527 |      |  |   | 57,292   |   |  |      | 34,445 |   |  |   | 24,157  |  
|                                                                 |  |                                          |         |   |      |   |         |      |  |   |          |   |  |      |        |   |  |   |         |  



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Our results for the year ended December 31, 2004 include the acquired operations of ACLARA for the
period December 10, 2004 to December 31, 2004. Our results for the year ended December 31, 2006 include the impact of the adoption of SFAS 123(R), Share-Based Payments, on January 1, 2006. See notes to the financial
statements for a description of the number of shares used in the computation of the basic and diluted net loss per common share.



|                                                   |  |                |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|-------------------------------------------------- |  | -------------- | -------- | - | ---- | - | -------- | ---- |  | - | -------- | - |  | ---- | -------- | - |  | - | -------- | -
|                                                   |  | December 31,   |         
|                                                   |  | 2006           |          |   | 2005 |   |          | 2004 |  |   | 2003     |   |  | 2002 |         
|                                                   |  | (In thousands) |         
|                                                   |  | (Unaudited)    |         
|Balance Sheet Data:                                |  |                |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Cash, cash equivalents, and short-term investments |  | $              | 31,130   |   |      | $ | 65,014   |      |  | $ | 78,848   |   |  | $    | 9,430    |   |  | $ | 11,145   |  
|Accounts receivable, net                           |  |                | 6,849    |   |      |   | 9,063    |      |  |   | 7,251    |   |  |      | 6,165    |   |  |   | 4,924    |  
|Working capital                                    |  |                | 21,603   |   |      |   | 23,984   |      |  |   | 73,463   |   |  |      | 13,038   |   |  |   | (239     | )
|Restricted cash                                    |  |                |         |   |      |   | 50       |      |  |   | 457      |   |  |      | 776      |   |  |   | 707      |  
|Total assets                                       |  |                | 60,845   |   |      |   | 97,678   |      |  |   | 107,635  |   |  |      | 28,378   |   |  |   | 30,486   |  
|Current portion of contingent value rights         |  |                | 2,813    |   |      |   | 42,676   |      |  |   |         |   |  |      |         |   |  |   |         |  
|Long-term portion of contingent value rights       |  |                |         |   |      |   |         |      |  |   | 15,269   |   |  |      |         |   |  |   |         |  
|Long-term portion of restructuring costs           |  |                | 868      |   |      |   | 1,916    |      |  |   | 1,710    |   |  |      |         |   |  |   |         |  
|Long-term convertible promissory note              |  |                | 25,000   |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Long-term portion of loans payable                 |  |                |         |   |      |   | 233      |      |  |   | 311      |   |  |      |         |   |  |   |         |  
|Long-term portion of capital lease obligations     |  |                | 92       |   |      |   | 212      |      |  |   | 36       |   |  |      | 87       |   |  |   | 419      |  
|Redeemable convertible preferred stock             |  |                |         |   |      |   |         |      |  |   | 1,810    |   |  |      | 1,994    |   |  |   | 4,249    |  
|Accumulated deficit                                |  |                | (263,991 | ) |      |   | (225,288 | )    |  |   | (187,702 | ) |  |      | (106,272 | ) |  |   | (100,764 | )
|Total stockholders equity                         |  |                | 13,908   |   |      |   | 41,771   |      |  |   | 72,673   |   |  |      | 20,587   |   |  |   | 7,014    |  



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Item 7.Managements Discussion and Analysis of Financial Condition and Results of Operations

The following discussion of the financial condition and results of operations should be read in conjunction with the financial statements and the notes thereto included in this Annual Report on Form 10-K. The estimates and certain other
statements below are forward-looking statements that involve risks and uncertainties. Our actual future capital requirements and the adequacies of our available funds will depend on many factors, including those under Risk Factors.

OVERVIEW

We are a life sciences
company committed to advancing personalized medicine and improving patient outcomes through the development of innovative molecular diagnostic products that guide and target the most appropriate treatments. Through a comprehensive understanding of
the genetics, biology and pathology of particular diseases, we have pioneered and are developing molecular diagnostics and laboratory services that are designed to:



| |  |  | enable physicians to better manage infectious diseases and cancers by providing the critical information that helps them prescribe personalized treatments for
patients by matching the underlying molecular features of an individual patients disease to the drug expected to have maximal therapeutic benefit; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | enable pharmaceutical companies to develop new and improved anti-viral therapeutics and targeted cancer therapeutics more efficiently and cost effectively by
providing enhanced patient selection and monitoring capabilities throughout the development process.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We are a leader in
developing and commercializing innovative products that help guide and improve the treatment of infectious diseases, cancer and other serious diseases. Our goal with personalized medicine is to enable the management of diseases at the individual
patient level through the use of sophisticated diagnostics that permit the targeting of therapeutics to those patients most likely to respond to or benefit from them, thereby offering the right treatment to the right patient atthe
right time.

Our PhenoSense and GeneSeq products provide a practical method for measuring the impact of genetic mutations on human immunodeficiency virus, or HIV, drug resistance. This information is used to optimize
various treatment options for the individual patient. We currently market phenotypic and genotypic resistance testing products directed at patients with HIV infection and the drug classes currently approved for use. In addition, we have resistance
tests in development or already in research use that are relevant to new drug classes, such as the integrase, entry and assembly classes. In addition to these resistance tests, our Trofile Co-Receptor Tropism Assay has been used for patient selection in the phase III trials
of the new class of CCR5 antagonists. The first of these, maraviroc from Pfizer, is currently the subject of an NDA that has been accepted for priority review by the FDA. We expect that the Trofile Assay may be used for patient selection
after regulatory approval of maraviroc and other CCR5 antagonists.

Over the last several years, we have built a business based on
the personalized medicine approach in HIV drug resistance testing and in patient selection. We now seek to leverage the experience and infrastructure we have built in the HIV market to the potentially larger market opportunity of cancer utilizing
our proprietary eTag technology, In the
future, we plan to seek opportunities to address an even broader range of serious diseases.

New targeted drug therapies are being
introduced for the treatment of cancer. Our proprietary eTag technology provides an assay platform for analyzing very small amounts of tumor samples recovered and prepared in a variety of methods, including formalin fixation, the current
standard technique in hospital pathology laboratories. We believe this analytical platform may be well suited for the next generation of targeted cancer therapeutics. We believe that, upon completion of development, our eTag assays will
permit the prediction, with a high degree of accuracy, of the likelihood of a patients cancer responding to a given therapy,



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facilitating the selection of more precise and effective therapeutic options. We are developing Epidermal Growth Factor Receptor, or EGFR/HER, eTag
assays that we believe will enable physicians to identify the appropriate course of treatment for cancers that have a particular molecular profile. Our current focus is on drugs that target the EGFR/HER receptor family, initially in breast cancer
but subsequently in lung and other cancers. We intend to develop eTag assays that target other protein drug targets and signaling pathways that are key drivers of proliferation or survival in cancer cells.

We have incurred losses each year since inception. As of December 31, 2006, we had an accumulated deficit of approximately $264.0 million, including
a charge in 2004 of $100.6 million for in-process research and development related to our merger with ACLARA. We expect to incur additional operating losses at least for the next twelve months as we complete the development of the eTag
technology, transfer the assays into the clinical laboratory, conduct clinical studies and develop the commercial infrastructure to support a commercial launch.

ISSUANCE OF 0% CONVERTIBLE SENIOR UNSECURED NOTES

In January 2007, we issued $30 million principal amount of 0%
Convertible Senior Unsecured Notes due 2026 (the Notes). The aggregate purchase price for the Notes is approximately $22.5 million. The Notes do not bear interest and are convertible, at the option of the holder of such Notes, into
shares of our common stock at an initial conversion price of $2.52 per share, which is equivalent to an initial conversion rate of approximately 396.8254 shares per $1,000 principal amount of Notes. The conversion price will adjust automatically
upon certain changes to our capitalization. Although the Notes are due in December 2026, the Notes may be called by the holders at their option at December 31, 2011, December 31, 2016 or December 31, 2021 at a price equal to 100% of
the accreted value.

Following the effectiveness of the registration statement covering the estimated number of common shares underlying
the Notes, we will have the option to cause all or any portion of the Notes to automatically convert at such time as the closing price of our common stock is greater than $3.15 for twenty out of thirty consecutive trading days, subject to certain
other limitations. The Notes are subordinated to all of our present senior debt, including the $25 million 3% Senior Secured Convertible Note due May 19, 2010 issued to Pfizer in May 2006, as amended as described below, and our line of credit
with Merrill Lynch.

AGREEMENTS WITH PFIZER, INC.

In May 2006, we entered into a non-exclusive Collaboration Agreement (the Collaboration Agreement) with Pfizer Inc. to facilitate the global availability for patient use of our proprietary Trofile Co-Receptor Tropism Assay (Trofile Assay).
Our Trofile Assay is used to identify which co-receptor a patients HIV uses for entry to cells and has been used in connection with phase III clinical trials of Pfizers investigational CCR5 antagonist, maraviroc. Applications to
the FDA and EMEA (the European Union regulatory agency) have been accepted for priority review by those agencies. Under the Collaboration Agreement we will have responsibility for making our Trofile Assay available in the U.S. and Pfizer will have
responsibility for sales, marketing and regulatory matters outside of the U.S. and will reimburse us for our expenses in establishing and maintaining the logistics infrastructure that may be necessary to make the assay available in those countries
as required by Pfizer. The Collaboration Agreement covers the period through December 31, 2009 and is renewable by Pfizer for five successive one year terms. We and Pfizer also extended the co-receptor portion of our existing services agreement
with Pfizer for support of potential additional Pfizer clinical trials through December 31, 2009.

We also entered into a note
purchase agreement with Pfizer under which Pfizer purchased a Senior Secured Convertible Note in the principal amount of $25 million (the Pfizer Note). The Pfizer Note bears a 3% annual interest rate, payable quarterly in cash or shares
of our common stock, at our option, and matures in May 2010 unless converted earlier. The Pfizer Note is convertible at Pfizers option into shares of our common stock at a conversion price of $2.7048 per share and will automatically convert
into shares of our common stock should the closing price of our common stock be greater than 150%, or $4.06 per share, of the conversion price for twenty out of thirty consecutive trading days. In addition, the Pfizer Note is secured by certain
assets related to our HIV



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testing business, is subject to certain covenants on our part and will be senior in right of payment to all existing and future indebtedness, subject to
certain limited exceptions. In connection with the sale of the Notes, as described above, Pfizer and U.S. Bank, National Association, as trustee, and we entered into a subordination agreement in January 2007, setting forth the terms under which the
Notes are subordinated to the Pfizer Note. We also amended our note purchase agreement with Pfizer, and amended and restated the Pfizer Note, to conform to certain terms of the subordination agreement. As amended, the Pfizer Note provides that
Monogram will be in default if (i) an event of default occurs and is continuing under the Notes and (ii) the Trustee or any holders of the Notes gives notice to us of its or their intent to either accelerate the Notes or exercise any other
remedies thereunder (subject to certain limited exceptions).

In accordance with Emerging Issues Task Force Issue No. 00-21, Revenue
Arrangements with Multiple Deliverables, (EITF 00-21) revenue arrangements entered into after June 15, 2003, that include multiple element arrangements are analyzed to determine whether the deliverables are divided into
separate units of accounting or as a single unit of accounting. Revenues are allocated to a delivered product or service when all of the following criteria are met: (1) the delivered item has value to the customer on a standalone basis;
(2) there is objective and reliable evidence of the fair value of the undelivered item; and (3) if the arrangement includes a general right of return relative to the delivered item, delivery or performance of the undelivered item is
considered probable and substantially in our control. If all of the three required criteria under EITF 00-21 are met, then the deliverables would be accounted for separately, completed as performed. Otherwise, the arrangement would be accounted for
as a single unit of accounting and the payments for performance obligations are recognized as revenue over the estimated period of when the performance obligations are performed. If we cannot reasonably estimate when a performance obligation either
ceases or becomes inconsequential, then revenue is deferred until we can reasonably estimate when the performance obligation ceases or becomes inconsequential.

The Pfizer collaboration is a multiple element arrangement, including supply of the Trofile Assay in additional clinical studies (including expanded access programs in both the U.S. and outside the U.S.), supply of
the Trofile Assay for clinical use outside of the U.S., reimbursement of costs for the establishment and operation of supply infrastructure outside of the U.S. and potential assistance to Pfizer in the establishment and operation of a second
facility for processing of tropism assays. Under the guidelines of EITF 00-21, we have determined that the collaboration with Pfizer should be accounted for as a single unit of accounting due to the absence of established fair values of certain
undelivered elements. Accordingly, we have deferred revenue under this collaboration until the earlier of establishment of fair values or completion of the deliverables.

Additionally, related direct costs that are contractually reimbursable on a non-refundable basis under this collaboration have been deferred.

MERGER WITH ACLARA BIOSCIENCES, INC.

On December 10, 2004, we completed our merger with ACLARA,
a Delaware corporation, pursuant to an Agreement and Plan of Merger and Reorganization dated May 28, 2004 as amended on October 18, 2004, or the Merger Agreement. Under the terms of the Merger Agreement, each outstanding share of ACLARA
common stock was exchanged for 1.7 shares of our common stock and 1.7 Contingent Value Rights, or CVRs. We issued 61.9 million shares of common stock valued at $1.94 per share. The fair value of our common stock utilized in determining the
purchase price was derived using our average stock price for the period two days before through two days after the amended terms of the acquisition were agreed to and announced on October 19, 2004. The CVRs were governed by a Contingent Value
Rights Agreement and are described in more detail in this Item 2 under the heading Contingent Value Rights. The transaction has been accounted for as a business combination and accordingly the assets acquired and liabilities assumed
have been recorded at their respective fair values. We engaged independent valuation specialists to assist us in determining the fair values of the assets acquired and liabilities assumed. Such a valuation requires us to make significant estimates
and assumptions, particularly with regard to the valuation of intangible assets.



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In connection with our merger with ACLARA, we have taken actions to integrate and restructure the former
ACLARA operations. We relocated the ACLARA personnel and operations from the facility in Mountain View, California to our South San Francisco, California facilities in the second quarter of 2005. A restructuring accrual was established for the costs
of vacating and subleasing the Mountain View facility including an estimate of the excess of our lease costs over our anticipated sublease income and for the anticipated severance costs for ACLARA employees whose employment was terminated as a
result of the merger. The accrual established at the closing of the merger related to the Mountain View facility was $3.0 million. In addition, a restructuring accrual of $1.1 million was established for the anticipated severance costs for ACLARA
employees whose employment was terminated as a result of the merger. Additional restructuring accruals, due to delays in vacating and subleasing the Mountain View facility, were recorded in the amounts of $1.6 million and $0.3 million in 2005 and
2006, respectively. In February 2007, we executed a termination agreement with respect to the lease in exchange for a reduced but fixed payment commitment over the remainder of the previous lease term. The initial charge of $1.6 million to the
estimates of completing the approved restructuring plans was recorded in goodwill and subsequent adjustments to these estimates have been recorded in our results of operations.

SUMMARY OF CRITICAL ACCOUNTING POLICIES AND ESTIMATES

Our financial statements have been prepared in
accordance with accounting principles generally accepted in the United States. The preparation of these financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues and
expenses. Note 1 to the financial statements describes the significant accounting policies used in the preparation of the financial statements. Certain of these significant accounting policies are considered to be critical accounting policies, as
defined below.

A critical accounting policy is defined as one that is both material to the presentation of our financial statements and
requires management to make difficult, subjective or complex judgments that could have a material effect on our financial condition and results of operations. Specifically, critical accounting estimates have the following attributes: 1) we are
required to make assumptions about matters that are highly uncertain at the time of the estimate; and 2) different estimates we could reasonably have used, or changes in the estimate that are reasonably likely to occur, would have a material effect
on our financial condition or results of operations.

Estimates and assumptions about future events and their effects cannot be determined
with certainty. We base our estimates on historical experience and on various other assumptions believed to be applicable and reasonable under the circumstances. These estimates may change as new events occur, as additional information is obtained
and as our operating environment changes. These changes have historically been minor and have been included in the financial statements as soon as they became known. Based on a critical assessment of our accounting policies and the underlying
judgments and uncertainties affecting the application of those policies, we believe that our financial statements are fairly stated in accordance with accounting principles generally accepted in the United States, and present a meaningful
presentation of our financial condition and results of operations.

We believe the following critical accounting policies reflect our more
significant estimates and assumptions used in the preparation of our financial statements:

Accounting for Stock-Based Compensation

Effective January 1, 2006, we adopted SFAS 123R under provisions of Staff Accounting Bulletin No. 107 (SAB 107) using the modified
prospective approach and therefore have not restated results for prior periods. Under this approach, share-based compensation cost is measured at the grant date, based on the estimated fair value of the award. Pursuant to the provisions of SFAS
123R, we record stock-based compensation as a charge to earnings net of the estimated impact of forfeited awards. As such, we recognize stock-based compensation cost only for those stock-based awards that are estimated to ultimately vest over their
requisite service period, based on the vesting provisions of the individual grants. We have no awards with market or performance conditions.



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On November 10, 2005, the Financial Accounting Standards Board, or FASB, issued FASB Staff Position
No. FAS 123R-3, Transition Election Related to Accounting for Tax Effects of Share-Based Payment Awards. We have elected to adopt the alternative transition method provided in this FASB Staff Position for calculating the tax effects of
share-based compensation pursuant to SFAS 123R. The alternative transition method includes a simplified method to establish the beginning balance of the additional paid-in capital pool related to the tax effects of employee share-based compensation,
which is available to absorb tax deficiencies recognized subsequent to the adoption of SFAS 123R. There was no tax benefit realized upon exercise of stock options during the three months ended December 31, 2006.

Prior to the adoption of SFAS 123R, we accounted for stock-based awards under the intrinsic method of Accounting Principles Board Opinion No. 25,
Accounting for Stock Issued to Employees (APB 25) and made pro forma footnote disclosures as required by Statement of Financial Accounting Standards No. 148, Accounting For Stock-Based CompensationTransition
and Disclosure, which amended Statement of Financial Accounting Standards No. 123, Accounting For Stock-Based Compensation. Under the intrinsic method, no stock-based compensation expense had been recognized in the statements
of operations because the exercise price of the stock options granted equaled the fair market value of the underlying stock on the date of grant. Pro forma net loss and pro forma net loss per share disclosed in the footnotes to the financial
statements were estimated using the Black-Scholes option-pricing model.

In accordance with SFAS 123R and SAB 107, we used the
Black-Scholes option-pricing valuation model to estimate the grant date fair value of our stock-based awards. The determination of fair value for stock-based awards on the date of grant using an option-pricing model requires management to make
certain assumptions regarding: (i) the expected volatility in the market price of our common stock over the expected term of the awards; (ii) dividend yield; (iii) risk-free interest rates; and (iv) actual and projected employee
exercise behaviors (referred to as the expected term). The expected volatility is based on the historical volatilities from our stock for the expected term in effect on the date of grant with considerations to similar public entities in similar
markets. The risk-free interest rate is based on the U.S. Zero Coupon Treasury yield for the expected term in effect on the date of grant. The expected term of options represents the period of time that options granted are expected to be outstanding
and is derived from actual historical exercise data with considerations to the contractual and vesting terms. The expected term of employee stock purchase plans is equal to the offering period. In addition, SFAS 123R requires us to estimate the
expected impact of forfeited awards and recognize stock-based compensation expense only for those awards expected to vest. The cumulative effect on current and prior periods of a change in the estimated forfeiture rate will be recognized as
compensation cost in earnings in the period of the revision. If actual forfeiture rates are materially different from our estimates or factors change and we employ different assumptions, stock-based compensation expense could be significantly
different from what we have recorded in the current period. We periodically review actual forfeiture experience and revise our estimates, as considered necessary.

In addition, we accounted for stock option grants to non-employees in accordance with the Emerging Issues Task Force Consensus No. 96-18, Accounting for Equity Instruments That Are Issued to Other Than
Employees for Acquiring, or in Conjunction with Selling, Goods or Services, which requires the options subject to vesting to be periodically re-valued over their service periods, which approximates the vesting period.

Revenue Recognition

Product revenue is recognized
upon completion of tests made on samples provided by customers and the shipment of test results to those customers. Services are provided to certain patients covered by various third-party payor programs, such as Medicare and Medicaid. Billings for
services under third-party payor programs are included in revenue net of allowances for differences between the amounts billed and estimated receipts under such programs. We estimate these allowances based on historical payment information and
current sales data. If the government and other third-party payors significantly change their reimbursement policies, an adjustment to the allowance may be necessary. Revenue generated from our database of resistance test results is recognized



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when earned under the terms of the related agreements, generally upon shipment of the requested reports. Contract revenue consists of revenue generated from
NIH grants, commercial assay development and other non-product revenue. NIH grant revenue is recorded on a reimbursement basis as grant costs are incurred. The costs associated with contract revenue are included in research and development expenses.
For commercial and research collaborations, we recognize non-refundable milestone payments received related to substantive at-risk milestones when performance of the milestone under the terms of the collaboration is achieved and there are no further
performance obligations. Research and development fees from commercial collaboration agreements are generally recognized as revenue on a straight-line basis over the life of the collaboration agreement or as the research work is performed. Up front
payments received in advance of meeting the revenue recognition criteria described above are deferred.

In accordance with Emerging Issues
Task Force Issue No. 00-21, Revenue Arrangements with Multiple Deliverables, (EITF 00-21) revenue arrangements entered into after June 15, 2003, that include multiple element arrangements are analyzed to determine
whether the deliverables are divided into separate units of accounting or as a single unit of accounting. Revenues are allocated to a delivered product or service when all of the following criteria are met: (1) the delivered item has value to
the customer on a standalone basis; (2) there is objective and reliable evidence of the fair value of the undelivered item; and (3) if the arrangement includes a general right of return relative to the delivered item, delivery or
performance of the undelivered item is considered probable and substantially in our control. If all of the three required criteria under EITF 00-21 are met, then the deliverables would be accounted for separately, completed as performed. Otherwise,
the arrangement would be accounted for as a single unit of accounting and the payments for performance obligations are recognized as revenue over the estimated period of when the performance obligations are performed. If we cannot reasonably
estimate when our performance obligation either ceases or becomes inconsequential, then revenue is deferred until we can reasonably estimate when the performance obligation ceases or becomes inconsequential.

Accounts Receivable

The process for estimating the
collectibility of receivables involves significant assumptions and judgments. Billings for services under third-party payor programs are recorded as revenue net of allowances for differences between amounts billed and the estimated receipts under
such programs. Adjustments to the estimated receipts, based on final settlement with the third-party payors, are recorded upon settlement as an adjustment to net revenue.

In addition, we review and estimate the collectibility of our receivables based on the period of time they have been outstanding. Historical collection and payor reimbursement experience is an integral part of the
estimation process related to reserves for doubtful accounts. In addition, we assess the current state of our billing functions in order to identify any known collection or reimbursement issues in order to assess the impact, if any, on our reserve
estimates, which involves judgment. We believe that the collectibility of our receivables is directly linked to the quality of our billing processes, most notably those related to obtaining the correct information in order to bill effectively for
the services we provide. As such, we have implemented procedures to reduce the number of requisitions that we receive from healthcare providers with missing or incorrect billing information. Changes in the allowance for doubtful accounts are
recorded as an adjustment to bad debt expense within general and administrative expenses. We believe that our collection and reserves processes, along with our close monitoring of our billing processes, helps to reduce the risk associated with
material revisions to reserve estimates resulting from adverse changes in collection and reimbursement experience and billing operations. We write off accounts against the allowance for doubtful accounts when they are deemed to be uncollectible.

Goodwill, Other Intangible Assets and Impairment of Long-Lived Assets

Goodwill represents the excess of the purchase consideration over the fair values of the identifiable assets acquired and liabilities assumed from our merger with ACLARA. In accordance with Statement of Financial



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Accounting Standards No. 142 Goodwill and Other Intangible Assets, or SFAS 142, we are required to test for impairment of goodwill on an
annual basis and at any other time if events occur or circumstances indicate that the carrying amount of goodwill may not be recoverable.

Other intangible assets include acquired developed product technology, costs of patents and patent applications related to products and products in development, which are capitalized and amortized on a straight-line basis over their
estimated useful lives. Circumstances that could trigger an impairment test include but are not limited to: a significant adverse change in the business or legal factors; an adverse action or assessment by a regulator; unanticipated competition or
loss of key personnel.

Deferred Tax Assets

We record a valuation allowance to reduce our deferred tax assets to the amount that we believe is more likely than not to be realized. Due to our lack of earnings history, the net deferred tax assets have been fully offset by a valuation
allowance.

Accounting for Merger with ACLARA

We accounted for the merger with ACLARA as a business combination which requires that the assets acquired and liabilities assumed be recorded at the date of acquisition at their respective fair values. The judgments made in determining the
estimated fair value assigned to each class of assets acquired and liabilities assumed, as well as asset lives, can materially impact our results of operations. Accordingly, for significant items, we obtained assistance from independent valuation
specialists.

The excess of the aggregate purchase consideration over the fair value of assets acquired and liabilities assumed has been
allocated to goodwill.

Contingent Value Rights

As part of the merger with ACLARA BioSciences, Inc. (ACLARA), we issued Contingent Value Rights (CVR) to ACLARA stockholders and were obligated to issue CVRs to holders of assumed ACLARA stock options upon future
exercise of those options. In June 2006, the amount payable related to the outstanding CVRs was determined at $0.88 per CVR and a cash payment of approximately $57.0 million was made to CVR holders on June 14, 2006. Holders of assumed ACLARA
options are entitled to receive a cash payment of $0.88, upon future exercise of those options, for each CVR that would have been issuable to them had the option been exercised prior to the CVR maturity date.

The liability under the CVRs was recorded at the closing of the merger with ACLARA at fair value, estimated using a calculation based on a Black-Scholes
valuation of the underlying CVR securities of $0.66 per CVR. Subsequent to the closing of the merger, an active trading market had been established and as a result, this liability was revalued based on the actual closing price of the CVRs on the OTC
Bulletin Board at the end of each quarter. In addition, we record an additional liability each quarter for additional CVRs related to assumed ACLARA stock options as they vest during each quarter.

RESULTS OF OPERATIONS

Year Ended December 31, 2006 Compared
to Years Ended December 31, 2005 and 2004.



|                 |  |                |        |      |   |        |  |   |       
|---------------- |  | -------------- | ------ | ---- | - | ------ |  | - | ------
|                 |  | 2006           |        | 2005 |   | 2004  
|                 |  | (In thousands)
|Product revenue  |  | $              | 45,150 |      | $ | 43,468 |  | $ | 34,811
|Contract revenue |  |                | 2,808  |      |   | 4,784  |  |   | 1,990 
|                 |  |                |        |      |   |        |  |   |       
|Total revenue    |  | $              | 47,958 |      | $ | 48,252 |  | $ | 36,801
|                 |  |                |        |      |   |        |  |   |       



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Revenue. Revenue was $48.0 million, $48.3 million and $36.8 million in 2006, 2005 and 2004,
respectively. Product revenue comprises revenue from our HIV testing services. The increase in product revenue of $1.7 million in 2006 as compared to 2005 and $8.7 million in 2005 as compared to 2004 was primarily due to the use of our testing
services, including our Trofile Co-Receptor Tropism Assay, in phase III clinical trials of Pfizers maraviroc, the first drug in a new class of HIV drugs called CCR5 antagonists. This generated a significant source of revenue in 2005 and
in the first half of 2006. The trial has now been completed, and applications for marketing approval have been accepted for priority review by the FDA and EMEA (the European Union regulatory agency). Our Trofile Assay may be used for patient
selection after regulatory approval of maraviroc. However, if maraviroc is not approved by the FDA, or if our test is not used for patient selection after approval, this could have a material negative impact on our revenues.

Contract revenue consists of revenues from eTag and oncology collaborations with pharmaceutical and biotechnology companies as well
as NIH research grants and other non-product revenue. These revenues increased in 2005 primarily due to the inclusion of revenue from eTag and oncology collaborations. In 2006, these sources of revenue were reduced as we focused our oncology
development efforts on enhancing the operational reproducibility and sensitivity of the eTag assays and studies designed to clinically validate an eTag test for applications in oncology. We intend to make our first oncology test
available to patients upon completion of transferring the eTag assays from the research setting into our CLIA certified laboratory and after sufficient clinical data is generated. We have an active program of applying for NIH funding and
currently have a number of active grants that we believe will help support the development of analytical and database tools to facilitate the identification and characterization of drug resistant strains of HIV, and assays that will aid in the
pre-clinical and clinical evaluation of the next generation of anti-viral therapeutics.

We anticipate quarterly variations in revenue due
primarily to fluctuations in the timing of various planned and ongoing clinical studies conducted by pharmaceutical companies.

We have
significant customer concentration and the loss of any major customer or the reduced use of our products by a major customer could have a significant negative impact on our revenue. In 2006, 2005 and 2004, approximately 21%, 22%, and 31%,
respectively of our revenues were derived from tests performed for the beneficiaries of the Medicare and Medicaid programs. Additionally, in 2006, 2005 and 2004, Pfizer Inc. represented approximately 19%, 19% and 7%, Quest Diagnostics Incorporated
represented approximately 11%, 11% and 12% and GlaxoSmithKline represented approximately 6%, 10% and 4% of our total revenue, respectively.

Cost of product revenue. Cost of product revenue was $22.7 million, $20.0 million and $17.8 million in 2006, 2005 and 2004, respectively. Included in these costs are materials, supplies, labor and overhead related to product revenue.
Gross margins were 50% in 2006, 54% in 2005 and 49% in 2004. The decrease in gross margin percentage in 2006 as compared to 2005 was due to the reduction in pharmaceutical testing revenues in the second half of 2006 due to the completion of the
phase III trial of maraviroc. The increase in gross margin percentage in 2005 as compared to 2004 was primarily due to the benefit of higher volumes provided by the growth in pharmaceutical testing revenue, especially revenue from Pfizer, and
the increased percentage of total revenue represented by these revenues. Additionally, stock-based compensation expenses recognized primarily in accordance with SFAS 123R in 2006 was $0.6 million. We anticipate that gross margin on product revenue
will continue to be affected by these factors, and, in time, by the introduction of oncology products, which we believe may have a higher gross margin than our HIV products.

Research and development. Research and development costs were $19.0 million, $19.0 million and $7.8 million in 2006, 2005 and 2004, respectively.
During 2006, research and development expenses was unchanged as compared to 2005, although a net unfavorable change relating to stock-based compensation expense of $2.3 million was offset by lower materials and supplies costs in our oncology
programs and reduced facilities expenses as a result of vacating the office and laboratory space in Mountain View, California in the second quarter of 2005. The increase of $11.2 million in 2005 as compared to 2004 was primarily due to costs
incurred



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related to oncology and eTag research and development programs, following the closing of the merger with ACLARA in December 2004. These costs were
offset by a net favorable $0.2 million adjustment from stock based compensation related to variable accounting for assumed ACLARA stock options with CVRs attached, CVR expenses related to vested options during the period and deferred compensation
amortization. In 2006, we recorded $2.1 million stock-based compensation expenses primarily related to the recognition of option and employee stock purchase plan expenses in accordance with SFAS 123R. In 2005, we recorded adjustments from
stock-based compensation related to variable accounting for the assumed ACLARA stock options with CVRs attached and CVR expenses related to vested options during the period. These adjustments were favorable by $0.2 million in 2005.

We have expanded our business focus from infectious diseases to include both infectious diseases and oncology, and accordingly, our research and
development expenditures have increased. These expenses are in connection with the further development of the eTag technology and preparations for the transfer of the eTagassays from the research setting to our CLIA certified clinical
laboratory and to generate clinical data in support of a commercial launch of eTag assays. The successful development of our products is highly uncertain. Completion dates and research and development expenses can vary significantly for each
product and are difficult to predict. For a more complete discussion of the risks and uncertainties associated with completing the development of products, see the Risk Factors above.

Our products in development for HIV and other infectious diseases target viral diseases and reflect a number of approaches to assessing resistance in
individual patients to particular drugs. Our product lines overlap and most of our research and development activities in infectious disease are advancing multiple potential product lines. Due to this substantial overlap, we do not track costs on a
project by project basis, except for the costs related to contract revenue. A portion of our infectious disease research and development expenses are funded by grants and commercial contracts and the following table sets our costs that are included
in research and development expenses that are associated with such revenues:



|           |  |                         |       |      |   |       |  |   |      
|---------- |  | ----------------------- | ----- | ---- | - | ----- |  | - | -----
|           |  | Year Ended December 31,
|           |  | 2006                    |       | 2005 |   | 2004 
|           |  | (In thousands)         
|NIH Grants |  | $                       | 1,816 |      | $ | 2,263 |  | $ | 1,990
|           |  |                         |       |      |   |       |  |   |      

Below is a summary of our products in development for HIV and other infectious diseases.



|                                                                                               |  |                  
|---------------------------------------------------------------------------------------------- |  | -----------------
|Infectious disease products in development                                                     |  | Status           
|Replication Capacity HIV, a measurement of fitness                                             |  | In development(1)
|PhenoSense HIV Entry, entry inhibitor assay                                                    |  | In development(2)
|GeneSeq HIV Entry, entry inhibitor assay                                                       |  | In development(3)
|PhenoSense and GeneSeq HIV Integrase, integrase inhibitor assays                               |  | In development(4)
|PhenoSense HIV Antibody Neutralization, a vaccine development and evaluation assay             |  | In development(5)
|PhenoSense and GeneSeq HIV Assembly/Maturation, virus assembly or maturation inhibitor assays. |  | In development(6)
|PhenoSense HCV, a phenotypic hepatitis C inhibitor assay                                       |  | In development(7)
|GeneSeq HCV, a genotypic hepatitis C inhibitor assay                                           |  | In development(7)

---

|(1) | The Replication Capacity HIV assay is validated in our clinical laboratory and the data is currently reported on our PhenoSense HIV and PhenoSense GT tests to both pharmaceutical
company customers and for patient testing. Clinical development work continues.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | The PhenoSense HIV Entry Assay has been validated in our clinical laboratory for enfuvirtide (Fuzeon) testing and is available to pharmaceutical company customers
and for patient testing. The assay is also
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | available to pharmaceutical company customers for testing of other new entry inhibitors in development, but is not yet validated in the clinical laboratory
for such use for other drugs for patent testing.
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | The GeneSeq HIV Entry Assay is in development. Additional development work is being conducted on this assay.
|--- | ------------------------------------------------------------------------------------------------------------

|(4) | The PhenoSense and GeneSeq HIV Integrase assays are validated for research purpose and available to pharmaceutical company customers. Assays for the integrase class are being
validated and are expected to be available for physician use as needed after the first integrase drug is approved by the FDA.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | The PhenoSense HIV Antibody Neutralization assay is validated for research purposes and available to pharmaceutical company customers. With NIH funding, additional development work
related to the use of our assays in vaccine development is being conducted.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | The PhenoSense and GeneSeq HIV Assembly/Maturation inhibitor assays are in development. Additional development work is being conducted on these assays.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------

|(7) | The GeneSeq HCV (NS5B) assay has been validated for research use and is available to pharmaceutical company customers. The GeneSeq HCV (NS3) and PhenoSense HCV assays are in
development pending the evolution of clinical or drug development need for such testing.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

A portion of our research and
development expenditures are now directed at continuing the research and development of the eTag System. Our eTag technology has potential application as a research tool in drug discovery and development in gene expression profiling
and protein expression analysis. These applications have been considered as developed product technology in the allocation of the purchase consideration for ACLARA. In addition, our eTag technology has the potential, through detection of
unique protein-based biomarkers, to differentiate likely responders from non-responders to certain targeted therapies in certain patient groups. Assays based on this technology have the potential to be used as aides for patient selection in
pharmaceutical companies clinical trials of therapeutic products targeted on specific patient populations and as diagnostic services and/or kits to guide physicians in the selection of appropriate therapies for particular patients. Products in
development are as follows:



|                                                                                                                             |  |                |    
|---------------------------------------------------------------------------------------------------------------------------- |  | -------------- | ---
|Oncology products in development                                                                                             |  | Status         |    
|Clinical assays for use in drug discovery, development and clinical evaluation by pharmaceutical and biotechnology customers |  | In development | (1)
|Clinical assays for diagnostic use in patient testing                                                                        |  | In development | (2)

---

|(1) | Completion of clinical assays for use in clinical trials by pharmaceutical and biotechnology customers is dependent on additional research and development and clinical studies in
collaboration with pharmaceutical and biotechnology companies. Such research and development and clinical studies are expected to be time-consuming, and could exceed one year.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Completion of clinical assays for diagnostic use in patient testing is dependent on the successful completion of additional research and development and clinical studies both in
collaboration agreements with pharmaceutical and biotechnology companies and in multiple and broader clinical studies that provide data that will enable physicians to utilize the tests. Completion of patient testing assays will also require the
development and validation of an assay in a CLIA clinical laboratory-certified format. Successful completion of such research and development and clinical studies is expected to be time-consuming, and could exceed one year.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

As with our infectious disease programs, many of our oncology research and development programs support multiple product areas. In particular, there
is substantial overlap between our research and development activities in support of protein expression assays and protein-based clinical assays for clinical collaborations and patient testing. Because of this overlap we do not identify and track
costs incurred on a project by project basis. The completion of our research and development projects are subject to a number of risks and uncertainties, including unplanned delays or expenditures during our product development, the extent of
clinical testing required for regulatory approvals, the timing and results of clinical trials, failure to validate our technology and products in clinical trials and failure to receive any necessary regulatory approvals. Because of these
uncertainties, the



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nature, timing and estimated costs of the efforts necessary to complete our research and development projects cannot be determined or estimated with any
degree of certainty. Any delays or additional research and development efforts may also require us to obtain additional sources of funding to complete development of our products. Our failure to complete development of our products would have a
material adverse impact on our ability to increase revenue and on our financial position and liquidity.

Purchased in-process research
and development. We recorded a $100.6 million charge for in-process research and development in 2004 for the portion of the purchase consideration of the ACLARA merger allocated to in-process research and development. This non-recurring charge
reflects the fair value of projects to develop eTag assays that can be commercialized as aides to patient selection in pharmaceutical company clinical trials and as diagnostic tests to assist physicians in determining the appropriate therapy
for individual cancer patients that had not yet reached technological feasibility and had no alternative future use as of the acquisition date. We engaged independent valuation specialists to assist us in determining the fair value of these
in-process research and development projects as well as developed product technology. The fair value is determined using the income approach. This method starts with a forecast of anticipated future net cash flows, which are then
adjusted to present value by applying an appropriate discount rate that reflects the risk factors associated with the cash flow streams. See Merger with ACLARA BioSciences, Inc. Note 6 to the financial statements for further discussion.

Sales and marketing. Sales and marketing expenses were $14.7 million, $12.6 million and $10.1 million in 2006, 2005 and 2004,
respectively. The increase in 2006 as compared to 2005 was primarily due to an increase in stock compensation expense of $1.8 million. The increase in 2005 as compared to 2004 was primarily attributable to business development activities for
oncology and increased marketing programs related to our products. In 2006, we recorded $1.7 million stock-based compensation expenses primarily related to the recognition of option and employee stock purchase plan expenses in accordance with SFAS
123R. In 2005, we recorded adjustments from stock-based compensation related to variable accounting for the assumed ACLARA stock options with CVRs attached and CVR expenses related to vested options during the period. These adjustments were
favorable by $0.2 million in 2005. We expect sales and marketing expenses to increase due to increased sales and marketing activities related to commercial introduction of our Trofile Co-Receptor Tropism Assay in anticipation of, and after, FDA
approval of Pfizers maraviroc. In addition, after we achieve clinical validation of our eTag assays, we expect our sales and marketing expenses, for promotional programs as well as sales and marketing personnel, will increase in
preparation for the introduction of oncology products.

General and administrative. General and administrative expenses were $15.0
million, $10.2 million and $10.2 million in 2006, 2005 and 2004, respectively. The increase in 2006 as compared to 2005 was primarily due to an increase of $4.0 million in stock-based compensation expense and to increases in professional services
fees. During 2005, general and administrative expenses were unchanged as compared to 2004 primarily due to a net favorable $1.5 million adjustment from stock based compensation related to variable accounting for assumed ACLARA stock options with
CVRs attached and CVR expenses related to vested options during the period offset by an increase in professional services fee, personnel costs and other administrative costs reflecting the increased scope of our operations. In 2006, we recorded $2.5
million stock-based compensation expenses primarily related to the recognition of option and employee stock purchase plan expenses in accordance with SFAS 123R. In 2005, we recorded adjustments from stock-based compensation related to variable
accounting for the assumed ACLARA stock options with CVRs attached and CVR expenses related to vested options during the period. These adjustments were favorable by $1.5 million in 2005. We expect general and administrative expenses in 2007 to
increase from 2006 levels to support the administrative infrastructure required to support growth of the business.

Stock Based
Compensation. Stock-based compensation expense related to employee stock options and employee stock purchases recognized under SFAS 123R and CVR charges related to options that vested in the year was $6.9 million in 2006. There was no
stock-based compensation expense recognized under SFAS 123R in 2005 and 2004. However, in connection with our merger with ACLARA, we recorded adjustments from stock-



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based compensation related to variable accounting for assumed ACLARA stock options, deferred compensation amortization and CVR expenses related to vested
options during those periods. These adjustments were favorable by $1.8 million and unfavorable by $3.4 million in 2005 and 2004, respectively. As of December 31, 2006, the total remaining unrecognized compensation cost related to the unvested
stock options amounted to $7.6 million, which will be amortized over the weighted-average remaining requisite service period of 1.22 years.

The table below sets out stock-based compensation expenses recognized primarily under SFAS 123R in 2006, stock-based compensation related to variable accounting for the assumed ACLARA stock options with CVRs attached in 2005 and 2004 and
CVR expenses related to vested options in 2006, 2005 and 2004.



|                         |  |                         |       |      |   |        |      |  |   |      
|------------------------ |  | ----------------------- | ----- | ---- | - | ------ | ---- |  | - | -----
|                         |  | Year ended December 31,
|                         |  | 2006                    |       | 2005 |   |        | 2004
|                         |  | (In thousands)         
|Cost of product revenue  |  | $                       | 597   |      | $ |       |      |  | $ |     
|Research & development   |  |                         | 2,075 |      |   | (185   | )    |  |   | 1,175
|Sales & marketing        |  |                         | 1,653 |      |   | (158   | )    |  |   | 398  
|General & administrative |  |                         | 2,536 |      |   | (1,460 | )    |  |   | 1,846
|                         |  |                         |       |      |   |        |      |  |   |      
|                         |  | $                       | 6,861 |      | $ | (1,803 | )    |  | $ | 3,419
|                         |  |                         |       |      |   |        |      |  |   |      

Stock compensation expense under SFAS123(R) is expected to continue to have an effect on results
of operations in future and this impact may be material.

In addition, we accounted for stock option grants to non-employees in accordance
with the Emerging Issues Task Force Consensus No. 96-18, Accounting for Equity Instruments That Are Issued to Other Than Employees for Acquiring, or in Conjunction with Selling, Goods or Services, which requires the options subject
to vesting to be periodically re-valued over their service periods, which approximates the vesting period. The impact of these options has not been material.

Lease termination charge. In March 2004, we terminated a lease for our original laboratory and office space of approximately 25,000 square feet in South San Francisco, California. Under the terms of the lease
termination, we recorded a charge of $0.4 million primarily related to the termination payment and the write-off of the net carrying value of the related leasehold improvements. This early termination enabled us to eliminate operating expenses
related to this lease going forward and reduce our aggregate remaining obligation by approximately half.

Interest income. Interest
income was $1.9 million, $2.3 million and $0.2 million in 2006, 2005 and 2004, respectively. The decrease of $0.4 million in 2006 as compared to 2005 was a result of lower average cash balances. The increase of $2.1 million in 2005 as compared to
2004 was primarily due to our increased level of cash and short-term investments and higher yields earned as a result of increased interest rates.

Interest expense. Interest expense was $0.6 million, $60,000 and $34,000 in 2006, 2005 and 2004, respectively. The increase in 2006 as compared to 2005 was a result of a convertible promissory note entered into with Pfizer. See Note
12, Collaboration and Note Purchase Agreement, to the financial statements for further discussion. The increase of $26,000 in 2005 as compared to 2004 was primarily due to a loan agreement assumed from our merger with ACLARA for
leasehold improvements at an interest rate of 8.5% per annum.

Contingent value rights revaluation. Our liability under the
CVRs, issued to ACLARA stockholders as part of the purchase consideration in the merger with ACLARA, was recorded at the closing of our merger with ACLARA at fair value, estimated using a calculation based on a Black-Scholes valuation of the
underlying CVR securities of $0.66 per CVR. Because subsequent to the closing of the merger, an active trading market had been established, this liability was revalued based on the actual closing price of the CVRs on the OTC Bulletin Board



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at the end of each quarter. In June 2006, the amount payable related to the outstanding CVRs was determined at $0.88 per CVR and a cash payment of
approximately $57.0 million was made to CVR holders on June 14, 2006. This revaluation led to a $16.5 million unfavorable adjustment to the liability and is reflected as a non-operating expense in the statement of operations for the year ended
2006.

Preferred stock dividend. We recorded a preferred stock dividend of $0.2 million and $0.3 million in 2005 and 2004,
respectively. The Series A Preferred Stock issued in 2001 bore dividends payable twice a year in shares of common stock. In June 2005, all outstanding shares of Series A Preferred Stock were converted to common stock.

LIQUIDITY AND CAPITAL RESOURCES

We expect our
available cash, cash equivalents and short-term investments of $31.1 million at December 31, 2006, funds provided by the sale of our products, contract revenue, borrowing under accounts receivable and equipment financing arrangements and net
proceeds, received in January 2007, of $20.9 million from the sale of our 0% Convertible Senior Unsecured Notes will be adequate to fund our operations at least for the next twelve months. See Note 14 Subsequent Events to the financial
statements for further discussion.

We have funded our operations since inception primarily through public and private sales of common and
preferred stock, issuance of convertible debt, equipment financing arrangements, product revenue, contract revenue, and a revolving line of credit. In particular, we have completed three private financings since our initial public offering in May
2000. In addition, during 2004 as the result of the merger with ACLARA, we acquired $74.8 million in cash and short term investments. In May 2006, we entered into an agreement with Pfizer for the purchase by Pfizer of a 3% Senior Secured Convertible
Note in the amount of $25 million. The note is due in 2010 and interest on these borrowings is payable in cash or stock, at our option. In September 2006, we entered into a credit and security agreement with Merrill for a $10 million revolving
credit line, under which borrowings are limited by eligible accounts receivable. In January 2007, we sold a 0% Convertible Senior Unsecured Note to an investor. The principal amount of the note is $30 million and reflecting the zero coupon nature of
the note, it was sold for an aggregate price of $22.5 million. After fees and expenses, net proceeds to us were approximately $20.9 million. The note may be called by the investor at December 31, 2011, December 31, 2016 or
December 31, 2021, at a price equal to 100% of the accreted value. Although we expect our operating and capital resources will be sufficient to meet future requirements for at least the next twelve months, we may have to raise additional funds
to continue the development and commercialization of our eTag technology and to support our business operations in general. These funds may not be available on favorable terms, or may not be available at all. If adequate funds are not
available on commercially reasonable terms, we may be required to curtail operations significantly or sell significant assets and may not be able to continue as a going concern. In addition, we may choose to raise additional capital due to market
conditions or strategic considerations even if we believe that we have sufficient funds for current or future operating plans.

In
connection with the merger with ACLARA, we issued CVRs to ACLARA stockholders and were obligated to issue CVRs to holders of assumed ACLARA stock options upon future exercise of those options. In June 2006, the amount payable related to the
outstanding CVRs was determined to be $0.88 per CVR and a cash payment of approximately $57.0 million was made to CVR holders on June 14, 2006. Holders of assumed ACLARA options are entitled to receive a cash payment of $0.88, upon future
exercise of those options, for each CVR that would have been issuable to them had the option been exercised prior to the CVR maturity date. At December 31, 2006, assumed ACLARA options to purchase 3.3 million shares of our common stock
were outstanding, of which 3.1 million shares were vested. The aggregate potential liability related to all these options at December 31, 2006 was $2.9 million. Of this, $2.7 million is reflected on the balance sheet at December 31,
2006 in respect of options vested and the remainder will be recognized as the options vest in the future. Upon exercise of these options, we will receive aggregate exercise proceeds of $6.6 million, offsetting the potential CVR payments of $2.7
million. See Note 7, Contingent Value Rights, of the financial statements for further discussion.



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Net cash used in operating activities was $24.2 million in 2006 primarily due to the payment of
approximately $57 million in settlement of the CVR liability of which $14.3 million was reflected in operating activities relating to the post merger CVR revaluation and $42.8 million was recorded in financing activities relating to the initial
valuation of the CVR at the closing of the merger with ACLARA at $0.66 per CVR. Net cash used in operating activities was $13.7 million and $2.6 million in 2005 and 2004, respectively. Cash flows from operating activities can vary significantly due
to various factors including trends in operating losses, changes in accounts receivable, accrued liabilities and deferred revenue related to new arrangements with customers. The average collection period of our accounts receivable as measured in
days sales outstanding can vary and is dependent on various factors, including the type of revenue (i.e. patient testing, pharmaceutical company testing or contract revenue), the payment terms related to that revenue, the complexities in third party
payer arrangements, and whether the related revenue was recorded at the beginning or end of a period.

Net cash provided by investing
activities in 2006 of $33.0 million resulted primarily from proceeds from maturities and sales (net of purchases) of short-term investments, offset by capital expenditures of $1.8 million. Net cash provided by investing activities in 2005 of $7.4
million resulted primarily from proceeds from maturities and sales (net of purchases) of short-term investments offset by payment of transaction costs related to our merger with ACLARA amounting to $4.7 million, capital expenditures of $3.2 million
and costs associated with acquiring other assets. Net cash used in investing activities in 2004 of $0.7 million resulted primarily from payment of transaction costs related to our merger with ACLARA of $2.3 million, capital expenditures of
$0.7 million and costs associated with acquiring other assets, partially offset by $2.1 million in cash and cash equivalents acquired in the merger with ACLARA.

Net cash used in financing activities in 2006 was $8.2 million resulted primarily from $25 million in proceeds from the issuance of a convertible promissory note to Pfizer, $5.6 million in proceeds from the revolving
credit line with Merrill Lynch Capital and $3.3 million in proceeds from the exercise of stock options for approximately 2.4 million shares of common stock, offset by the settlement of the CVR liability of approximately $57 million of
which $42.8 million was recorded in financing activities which related to the initial valuation of the CVR at the closing of the merger with ACLARA at $0.66 per CVR. The net cash provided by financing activities in 2005 of $7.9 million resulted
primarily from $5.8 million in proceeds from the exercise of warrants for approximately 5.2 million shares of common stock, offset by payments on loans and capital lease obligations. The net cash provided by financing activities in 2004 of $0.5
million resulted primarily from proceeds from common stock issuance and loan proceeds, partially offset by payments on loans and capital lease obligations.

Leases. At December 31, 2006, we leased a building of approximately 41,000 square feet in South San Francisco, California, comprising laboratory and office space. The lease expires in April 2010 and
provides an option to extend the term for an additional ten years. We also subleased approximately 27,000 square feet in another adjacent building in South San Francisco, California, comprising laboratory and office space. This sublease expires in
December 2007. In February 2007, we entered into a twelve month lease on approximately 9,000 square feet of office space in South San Francisco. In addition, as a result of our merger with ACLARA, we assumed the lease for a building of approximately
44,200 square feet in Mountain View, California comprising laboratory and office space. On February 7, 2007, we entered into a lease termination agreement with the landlord to terminate the lease prior to its scheduled expiry. See
Subsequent Events Note 14 to the financial statements for further discussion.

In August 2006, we entered into a loan agreement
of $0.8 million to finance our insurance premiums at an interest rate of 7.84% per annum. The loan was paid in full in January 2007.

In March 2004, we terminated a lease for our laboratory and office space of approximately 25,000 square feet in South San Francisco, California. Under the terms of the lease termination agreement, we paid and recorded a charge of $0.4
million primarily related to the termination payment and the write-off of the net carrying value of the related leasehold improvements.



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Contractual Obligations.At December 31, 2006, our contractual obligations for the next five
years and thereafter are as follows (in thousands):



|                                                 |  |                        |        |           |   |           |  |                  |        |       |   |   |  |   |       
|------------------------------------------------ |  | ---------------------- | ------ | --------- | - | --------- |  | ---------------- | ------ | ----- | - | - |  | - | ------
|                                                 |  | Payments Due By Period
|                                                 |  | Less Than1 Year        |        | 1-3 Years |   | 3-5 Years |  | More Than5 Years |        | Total
|                                                 |  | (In thousands)        
|Operating lease obligations                      |  | $                      | 2,801  |           | $ | 2,977     |  | $                | 355    |       | $ |  |  | $ | 6,133 
|Equipment financing arrangements                 |  |                        | 132    |           |   | 95        |  |                  |       |       |   |  |  |   | 227   
|Convertible promissory note                      |  |                        |       |           |   |          |  |                  | 25,000 |       |   |  |  |   | 25,000
|Convertible promissory note interest payment (1) |  |                        | 750    |           |   | 1,500     |  |                  | 473    |       |   |  |  |   | 2,723 
|Loans payable                                    |  |                        | 6,244  |           |   |          |  |                  |       |       |   |  |  |   | 6,244 
|Purchase obligations                             |  |                        | 275    |           |   |          |  |                  |       |       |   |  |  |   | 275   
|                                                 |  |                        |        |           |   |           |  |                  |        |       |   |   |  |   |       
|Total                                            |  | $                      | 10,202 |           | $ | 4,572     |  | $                | 25,828 |       | $ |  |  | $ | 40,602
|                                                 |  |                        |        |           |   |           |  |                  |        |       |   |   |  |   |       

---

|(1) | Subject to certain limitations, we are entitled to make such interest payments using shares of our common stock.
|--- | ----------------------------------------------------------------------------------------------------------------

The contractual obligations discussed above are fixed costs. If we are unable to generate sufficient cash from operations to meet these contractual
obligations, we may have to raise additional funds. These funds may not be available on favorable terms or at all.

Off-balance sheet
arrangements.In June 2002, we assigned a lease of excess laboratory and office space and sold the related leasehold improvements and equipment to a third party. In the event of default by the assignee, we would be contractually obligated for
payments under the lease of: $0.7 million in 2007; $1.5 million in 2008; $1.6 million in 2009; $1.6 million in 2010 and $0.7 million in 2011.

Long term capital and liquidity considerations. We expect that we will have to make substantial investments in operating and capital expenditures as we develop and commercialize new clinical testing products and expand the
availability of our current testing products.

During 2006, we made capital expenditures of approximately $1.8 million. While we do not
currently have any additional material commitments for future capital expenditures, we expect that we will have additional requirements for facilities and capital expenditures as we expand our clinical laboratory to accommodate commercial
availability of eTag assays for oncology, expand our commercial infrastructure in anticipation of the introduction of oncology products, potentially establish an FDA compliant manufacturing facility and make our HIV and oncology assays available
globally in support of drugs for which our tests may be important diagnostics. We have signed a short term lease for additional facilities to accommodate anticipated increased administrative and marketing activities in 2007. In addition, our
sublease on a building in South San Francisco of approximately 27,000 square feet expires at the end of 2007 and we are evaluating alternatives for 2008. The availability of facilities in South San Francisco is severely limited and there is no
guarantee that we will be able to identify suitable space at a commercially reasonable cost. In addition, alternative facilities may not be in close proximity to our existing facilities and this could cause disruption and inefficiencies in our
operations.

Due to increased market lease rates, the potential cost of moving to a new facility and the cost of leasehold improvements and
equipment in an alternative facility, our capital and operating costs could increase substantially in connection with our leasing of additional or replacement facilities.

From time to time, we may consider possible strategic transactions, including the potential acquisitions of products, technologies and companies, with the goal of further developing our business and maximizing
stockholder value. Such transactions, if any, could materially affect our future liquidity and capital resources. We



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may need to obtain additional funding by entering into new collaborations and strategic partnerships to enable us to develop and commercialize our products.
Even if we receive funding from future collaborations and strategic partnerships, we may need to raise additional capital in the public equity markets, through private equity financing or through debt financing. Further, any additional equity
financing may be dilutive to stockholders, and debt financing, if available, may involve restrictive covenants. Our failure to raise capital when needed may harm our business and operating results.

Income taxes.We have incurred net operating losses since inception. At December 31, 2006, we had federal and state net operating loss
carryforwards of approximately $280.8 million and $112.0 million, respectively. The federal net operating loss and credit carryforwards will expire at various dates between the years 2010 and 2026 if not utilized. The state of California net
operating losses will expire at various dates between the years 2012 and 2016, if not utilized. The federal and state operating loss carryforwards include deductions for stock options. Utilization of the federal and state net operating loss and
credit carryforwards may be subject to a substantial annual limitation due to the change in ownership provisions of the Internal Revenue Code of 1986. The annual limitation may result in the expiration of net operating losses and credits
before utilization. When utilized, the portion related to stock options deductions will be accounted for as a credit to shareholders equity rather than as a reduction of the income tax provision.

RECENTLY ISSUED ACCOUNTING STANDARDS

In February
2006, the Financial Accounting Standards Board (FASB) issued SFAS No. 155, Accounting for Certain Hybrid Financial Instruments (SFAS No. 155). SFAS No. 155 amends SFAS No. 133
Accounting for Derivative Instruments and Hedging Activities, and SFAS No. 140 Accounting for Transfers and Servicing of Financial Assets and Extinguishments of Liabilities and addresses the application of
SFAS No. 133 to beneficial interests in securitized financial assets. SFAS No. 155 establishes a requirement to evaluate interests in securitized financial assets to identify interests that are freestanding derivatives or that
are hybrid financial instruments that contain an embedded derivative requiring bifurcation. Additionally, SFAS No. 155 permits fair value measurement for any hybrid financial instrument that contains an embedded derivative that otherwise
would require bifurcation. SFAS No. 155 is effective for fiscal years beginning after September 15, 2006. We are currently evaluating the impact of adopting SFAS 155 on our financial statements.

In July 2006, the FASB issued FASB Interpretation No. 48, Accounting for Uncertainty in Income Taxes, an interpretation of FASB Statement
No. 109 (FIN 48). FIN 48 clarifies the accounting for uncertainty in income taxes by prescribing the recognition threshold a tax position is required to meet before being recognized in the financial statements. It
also provides guidance on derecognition, classification, interest and penalties, accounting in interim periods, disclosure, and transition. FIN 48 is effective for fiscal years beginning after December 15, 2006 and is required to be
adopted by us in 2007. We are currently evaluating the impact of adopting FIN 48 on our financial statements.

In September 2006, the FASB
issued statement No. 157, Fair value Measurements (SFAS 157). This standard establishes the framework for measuring fair value and expands the disclosure requirement for fair value measurements. SFAS 157 is effective for
fiscal years beginning after November 15, 2007. We are currently evaluating the impact of adopting SFAS 157 on our financial statements.

In September 2006, the Securities and Exchange Commission issued Staff Accounting Bulletin No. 108 (SAB 108) that provides guidance on the process of quantifying financial statement misstatements. This bulletin is effective
for any interim period of the first fiscal year ending after November 15, 2006. The adoption of SAB 108 did not have a significant effect on our financial statements.

In February 2007, the FASB issued SFAS No. 159, The Fair Value Option for Financial Assets and Financial Liabilities
(SFAS 159) which permits entities to choose to measure many financial instruments and



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certain other items at fair value that are not currently required to be measured at fair value. SFAS 159 is effective for fiscal years beginning after
November 15, 2007. We are currently evaluating the impact of adopting SFAS 159 on our financial statements.

Item 7A.Quantitative and Qualitative Disclosures about Market Risk

Our exposure to
interest rate risk relates primarily to our investment portfolio. Fixed rate securities may have their fair market value adversely impacted due to fluctuations in interest rates, while floating rate securities may produce less income than expected
if interest rates fall. Due in part to these factors, our future investment income may fall short of expectations due to changes in interest rates or we may suffer losses in principle if forced to sell securities that have declined in market value
due to changes in interest rates. The primary objective of our investment activities is to preserve principal while at the same time maximize yields without significantly increasing risk. To achieve this objective, we invest in debt instruments of
the U.S. Government and its agencies and high-quality corporate issuers, and, by policy, restrict our exposure to any single corporate issuer by imposing concentration limits. To minimize the exposure due to adverse shifts in interest rates, we
maintain investments at an average maturity of generally less than two years.

The following tables present the hypothetical changes in
fair values in our cash, cash equivalents and short-term investments held at December 31, 2006 that are sensitive to the changes in interest rates. The modeling technique used measures the change in fair values arising from hypothetical
parallel shifts in the yield curve of plus or minus 50 basis points (BPS), 100 BPS and 150 BPS. Fair values represent the market principal at December 31, 2006 (in thousands).



|                                        |  |                                                  |        |                                                  |   |        |  |       |        |        |   |         |  |         |        |  |   |        |  |   |       
|--------------------------------------- |  | ------------------------------------------------ | ------ | ------------------------------------------------ | - | ------ |  | ----- | ------ | ------ | - | ------- |  | ------- | ------ |  | - | ------ |  | - | ------
|                                        |  | Given an Interest Rate Decrease ofX Basis Points |        | Given an Interest Rate Increase ofX Basis Points
|Issuer                                  |  | 150 BPS                                          |        | 100 BPS                                          |   | 50 BPS |  | 0 BPS |        | 50 BPS |   | 100 BPS |  | 150 BPS
|Money Market                            |  | $                                                | 3      |                                                  | $ | 3      |  | $     | 3      |        | $ | 3       |  | $       | 3      |  | $ | 3      |  | $ | 3     
|Bonds of US Government and its agencies |  |                                                  | 23,001 |                                                  |   | 22,956 |  |       | 22,912 |        |   | 22,867  |  |         | 22,732 |  |   | 22,777 |  |   | 22,822
|                                        |  |                                                  |        |                                                  |   |        |  |       |        |        |   |         |  |         |        |  |   |        |  |   |       
|                                        |  | $                                                | 23,004 |                                                  | $ | 22,959 |  | $     | 22,915 |        | $ | 22,870  |  | $       | 22,735 |  | $ | 22,780 |  | $ | 22,825
|                                        |  |                                                  |        |                                                  |   |        |  |       |        |        |   |         |  |         |        |  |   |        |  |   |       

The weighted-average maturity of our marketable investments at December 31, 2006 was 143
days.

We have exposure to changes in interest rates on our revolving credit line with Merrill Lynch Capital, which bears interest at a
rate per annum equal to a published LIBOR rate plus 4.75%. As of December 31, 2006 approximately $5.6 million was outstanding under the revolving credit line.

We do not utilize derivative financial instruments, derivative commodity instruments or other market risk sensitive instruments, positions or
transactions in any material fashion.

We have operated primarily in the United States and all sales to date have been made in U.S.
Dollars. Accordingly, we have not had any material exposure to foreign currency rate fluctuations.



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Item 8.Financial Statements and Supplementary Data

INDEX TO FINANCIAL STATEMENTS



|                                                                                        |  |     
|--------------------------------------------------------------------------------------- |  | ----
|                                                                                        |  | Page
|Report of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm     |  | 64  
|Report of Ernst & Young LLP, Independent Registered Public Accounting Firm              |  | 66  
|Balance Sheets as of December 31, 2006 and 2005                                         |  | 67  
|Statements of Operations for the years ended December 31, 2006, 2005 and 2004           |  | 68  
|Statements of Stockholders Equity for the years ended December 31, 2006, 2005 and 2004 |  | 69  
|Statements of Cash Flows for the years ended December 31, 2006, 2005 and 2004           |  | 70  
|Notes to Financial Statements                                                           |  | 71  
|Financial Statement Schedule: Schedule IIValuation and Qualifying Accounts             |  | S-1 



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REPORT OF PRICEWATERHOUSECOOPERS LLP, INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and
Stockholders

Monogram Biosciences, Inc. (formerly ViroLogic, Inc.)

We have completed integrated audits of Monogram Biosciences, Incs (formerly ViroLogic, Inc.) 2006 and 2005 financial statements and of its internal control over financial reporting as of December 31, 2006,
in accordance with the standards of the Public Company Accounting Oversight Board (United States). Our opinions, based on our audits, are presented below.

Financial statements and financial statement schedule

In our opinion, the financial statements listed in Item 15(a)(1)
present fairly, in all material respects, the financial position of Monogram Biosciences, Incs (formerly ViroLogic, Inc.) at December 31, 2006 and 2005, and the results of its operations and its cash flows for each of the two years in the
period ended December 31, 2006 in conformity with accounting principles generally accepted in the United States of America. In addition, in our opinion, the financial statement schedule listed in the index appearing under Item 15(a)(2) presents
fairly, in all material respects, the information set forth therein when read in conjunction with the related financial statements. These financial statements and financial statement schedule are the responsibility of the Companys management.
Our responsibility is to express an opinion on these financial statements and financial statement schedule based on our audits. We conducted our audits of these statements in accordance with the standards of the Public Company Accounting Oversight
Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit of financial statements includes examining, on a test
basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, and evaluating the overall financial statement presentation. We believe that
our audits provide a reasonable basis for our opinion.

As discussed in Note 1 to the financial statements, the Company changed the manner
in which it accounts for stock-based compensation in fiscal year 2006.

Internal control over financial reporting

Also, in our opinion, managements assessment, included in Managements Report on Internal Control over Financial Reporting appearing under
Item 9A, that the Company maintained effective internal control over financial reporting as of December 31, 2006 based on established in Internal ControlIntegrated Frameworkissued by the Committee of Sponsoring Organizations
of the Treadway Commission (COSO), is fairly stated, in all material respects, based on those criteria. Furthermore, in our opinion, the Company maintained, in all material respects, effective internal control over financial reporting as of
December 31, 2006, based on criteria established in Internal ControlIntegrated Framework issued by the COSO. The Companys management is responsible for maintaining effective internal control over financial reporting and for
its assessment of the effectiveness of internal control over financial reporting. Our responsibility is to express opinions on managements assessment and on the effectiveness of the Companys internal control over financial reporting
based on our audit. We conducted our audit of internal control over financial reporting in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to
obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. An audit of internal control over financial reporting includes obtaining an understanding of internal control over
financial reporting, evaluating managements assessment, testing and evaluating the design and operating effectiveness of internal control, and performing such other procedures as we consider necessary in the circumstances. We believe that our
audit provides a reasonable basis for our opinions.



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A companys internal control over financial reporting is a process designed to provide reasonable
assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A companys internal control over financial reporting
includes those policies and procedures that (i) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (ii) provide reasonable
assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with
authorizations of management and directors of the company; and (iii) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the companys assets that could have a material
effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or
detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or
procedures may deteriorate.

/s/    PricewaterhouseCoopers LLP

San Jose, California

March 8, 2007



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REPORT OF ERNST & YOUNG LLP, INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and
Stockholders

Monogram Biosciences, Inc. (Formerly ViroLogic, Inc.)

We have audited the accompanying statement of operations, stockholders equity, and cash flows of Monogram Biosciences, Inc. (formerly ViroLogic, Inc.) for the year ended December 31, 2004. Our audit also
included the financial statement schedule listed at Item 15(a)(2) of this Annual Report on Form 10-K for the year ended December 31, 2004. These financial statements and schedule are the responsibility of the management of Monogram
Biosciences, Inc. (formerly ViroLogic, Inc.). Our responsibility is to express an opinion on these financial statements and schedule based on our audit.

We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about
whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles
used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audit provides a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the results of operations and cash flows of Monogram
Biosciences, Inc. (formerly ViroLogic, Inc.) for the year ended December 31, 2004, in conformity with U.S. generally accepted accounting principles. Also, in our opinion, the related financial statement schedule for the year ended
December 31, 2004, when considered in relation to the basic financial statements taken as a whole, presents fairly, in all material respects, the information set forth therein.

/s/    ERNST & YOUNG LLP

Palo Alto, California

March 14, 2005



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MONOGRAM BIOSCIENCES, INC.

BALANCE SHEETS

(In thousands, except share and per share data)



|                                                                                                                                                                     |  |              |          |   |      |   |          |  
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | -------- | - | ---- | - | -------- | -
|                                                                                                                                                                     |  | December 31, |         
|                                                                                                                                                                     |  | 2006         |          |   | 2005 |  
|ASSETS                                                                                                                                                               |  |              |          |   |      |   |          |  
|Current assets:                                                                                                                                                      |  |              |          |   |      |   |          |  
|Cash and cash equivalents                                                                                                                                            |  | $            | 8,263    |   |      | $ | 7,616    |  
|Short-term investments                                                                                                                                               |  |              | 22,867   |   |      |   | 57,398   |  
|Restricted cash                                                                                                                                                      |  |              |         |   |      |   | 50       |  
|Accounts receivable, net of allowance for doubtful accounts of $965 and $1,044 at December 31, 2006 and 2005,
respectively                                           |  |              | 6,849    |   |      |   | 9,063    |  
|Prepaid expenses                                                                                                                                                     |  |              | 1,234    |   |      |   | 1,107    |  
|Inventory                                                                                                                                                            |  |              | 961      |   |      |   | 1,170    |  
|Other current assets                                                                                                                                                 |  |              | 378      |   |      |   | 790      |  
|                                                                                                                                                                     |  |              |          |   |      |   |          |  
|Total current assets                                                                                                                                                 |  |              | 40,552   |   |      |   | 77,194   |  
|Property and equipment, net                                                                                                                                          |  |              | 7,463    |   |      |   | 8,580    |  
|Deferred costs relating to collaboration agreement                                                                                                                   |  |              | 1,783    |   |      |   |         |  
|Goodwill                                                                                                                                                             |  |              | 9,927    |   |      |   | 9,927    |  
|Other assets                                                                                                                                                         |  |              | 1,120    |   |      |   | 1,977    |  
|                                                                                                                                                                     |  |              |          |   |      |   |          |  
|Total assets                                                                                                                                                         |  | $            | 60,845   |   |      | $ | 97,678   |  
|                                                                                                                                                                     |  |              |          |   |      |   |          |  
|LIABILITIES AND STOCKHOLDERS EQUITY                                                                                                                                 |  |              |          |   |      |   |          |  
|Current liabilities:                                                                                                                                                 |  |              |          |   |      |   |          |  
|Accounts payable                                                                                                                                                     |  | $            | 1,271    |   |      | $ | 1,751    |  
|Accrued compensation                                                                                                                                                 |  |              | 2,258    |   |      |   | 2,271    |  
|Accrued liabilities                                                                                                                                                  |  |              | 4,720    |   |      |   | 4,116    |  
|Current portion of restructuring costs                                                                                                                               |  |              | 1,128    |   |      |   | 1,417    |  
|Deferred revenue                                                                                                                                                     |  |              | 404      |   |      |   | 383      |  
|Current portion of loans payable                                                                                                                                     |  |              | 6,235    |   |      |   | 477      |  
|Current portion of capital lease obligations                                                                                                                         |  |              | 120      |   |      |   | 119      |  
|Contingent value rights                                                                                                                                              |  |              | 2,813    |   |      |   | 42,676   |  
|                                                                                                                                                                     |  |              |          |   |      |   |          |  
|Total current liabilities                                                                                                                                            |  |              | 18,949   |   |      |   | 53,210   |  
|Long-term portion of restructuring costs                                                                                                                             |  |              | 868      |   |      |   | 1,916    |  
|Long-term convertible promissory note                                                                                                                                |  |              | 25,000   |   |      |   |         |  
|Long-term deferred revenue                                                                                                                                           |  |              | 1,783    |   |      |   |         |  
|Long-term portion of loans payable                                                                                                                                   |  |              |         |   |      |   | 233      |  
|Long-term portion of capital lease obligations                                                                                                                       |  |              | 92       |   |      |   | 212      |  
|Other long-term liabilities                                                                                                                                          |  |              | 245      |   |      |   | 336      |  
|                                                                                                                                                                     |  |              |          |   |      |   |          |  
|Total liabilities                                                                                                                                                    |  |              | 46,937   |   |      |   | 55,907   |  
|                                                                                                                                                                     |  |              |          |   |      |   |          |  
|Commitments and contingencies (Note 8)                                                                                                                               |  |              |          |   |      |   |          |  
|Stockholders equity:                                                                                                                                                |  |              |          |   |      |   |          |  
|Preferred stock, $0.001 par value, 5,000,000 shares authorized, designated by series, none issued and outstanding at December 31, 2006 and
2005, respectively        |  |              |         |   |      |   |         |  
|Common stock, $0.001 par value, 200,000,000 shares authorized; 131,307,374 and 127,668,136 shares issued and outstanding at December 31, 2006
and 2005, respectively |  |              | 131      |   |      |   | 128      |  
|Additional paid-in capital                                                                                                                                           |  |              | 277,892  |   |      |   | 267,526  |  
|Accumulated other comprehensive loss                                                                                                                                 |  |              | (124     | ) |      |   | (514     | )
|Deferred compensation                                                                                                                                                |  |              |         |   |      |   | (81      | )
|Accumulated deficit                                                                                                                                                  |  |              | (263,991 | ) |      |   | (225,288 | )
|                                                                                                                                                                     |  |              |          |   |      |   |          |  
|Total stockholders equity                                                                                                                                           |  |              | 13,908   |   |      |   | 41,771   |  
|                                                                                                                                                                     |  |              |          |   |      |   |          |  
|Total liabilities and stockholders equity                                                                                                                           |  | $            | 60,845   |   |      | $ | 97,678   |  
|                                                                                                                                                                     |  |              |          |   |      |   |          |  

The accompanying notes are an integral part of the financial statements.



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MONOGRAM BIOSCIENCES, INC.

STATEMENTS OF OPERATIONS

(In thousands, except per share amounts)



|                                                                                  |  |                         |         |   |      |   |         |      |  |   |          |  
|--------------------------------------------------------------------------------- |  | ----------------------- | ------- | - | ---- | - | ------- | ---- |  | - | -------- | -
|                                                                                  |  | Year Ended December 31, |        
|                                                                                  |  | 2006                    |         |   | 2005 |   |         | 2004 | 
|Revenue:                                                                          |  |                         |         |   |      |   |         |      |  |   |          |  
|Product revenue                                                                   |  | $                       | 45,150  |   |      | $ | 43,468  |      |  | $ | 34,811   |  
|Contract revenue                                                                  |  |                         | 2,808   |   |      |   | 4,784   |      |  |   | 1,990    |  
|                                                                                  |  |                         |         |   |      |   |         |      |  |   |          |  
|Total revenue                                                                     |  |                         | 47,958  |   |      |   | 48,252  |      |  |   | 36,801   |  
|Operating costs and expenses:                                                     |  |                         |         |   |      |   |         |      |  |   |          |  
|Cost of product revenue                                                           |  |                         | 22,703  |   |      |   | 20,001  |      |  |   | 17,794   |  
|Research and development                                                          |  |                         | 18,981  |   |      |   | 18,996  |      |  |   | 7,839    |  
|In-process research and development                                               |  |                         |        |   |      |   |        |      |  |   | 100,600  |  
|Sales and marketing                                                               |  |                         | 14,735  |   |      |   | 12,588  |      |  |   | 10,056   |  
|General and administrative                                                        |  |                         | 15,042  |   |      |   | 10,200  |      |  |   | 10,192   |  
|Lease termination charge                                                          |  |                         |        |   |      |   |        |      |  |   | 433      |  
|                                                                                  |  |                         |         |   |      |   |         |      |  |   |          |  
|Total operating costs and expenses                                                |  |                         | 71,461  |   |      |   | 61,785  |      |  |   | 146,914  |  
|                                                                                  |  |                         |         |   |      |   |         |      |  |   |          |  
|Operating loss                                                                    |  |                         | (23,503 | ) |      |   | (13,533 | )    |  |   | (110,113 | )
|Interest income                                                                   |  |                         | 1,874   |   |      |   | 2,303   |      |  |   | 198      |  
|Interest expense                                                                  |  |                         | (624    | ) |      |   | (60     | )    |  |   | (34      | )
|Contingent value rights revaluation                                               |  |                         | (16,450 | ) |      |   | (26,296 | )    |  |   | 28,519   |  
|                                                                                  |  |                         |         |   |      |   |         |      |  |   |          |  
|Net loss                                                                          |  |                         | (38,703 | ) |      |   | (37,586 | )    |  |   | (81,430  | )
|Preferred stock dividend                                                          |  |                         |        |   |      |   | (162    | )    |  |   | (324     | )
|                                                                                  |  |                         |         |   |      |   |         |      |  |   |          |  
|Loss applicable to common stockholders                                            |  | $                       | (38,703 | ) |      | $ | (37,748 | )    |  | $ | (81,754  | )
|                                                                                  |  |                         |         |   |      |   |         |      |  |   |          |  
|Basic and diluted net loss per common share                                       |  | $                       | (0.30   | ) |      | $ | (0.31   | )    |  | $ | (1.43    | )
|                                                                                  |  |                         |         |   |      |   |         |      |  |   |          |  
|Weighted-average shares used in computing basic and diluted loss per common share |  |                         | 130,447 |   |      |   | 123,527 |      |  |   | 57,292   |  
|                                                                                  |  |                         |         |   |      |   |         |      |  |   |          |  

The accompanying notes are an integral part of the financial statements.



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MONOGRAM BIOSCIENCES, INC.

STATEMENTS OF STOCKHOLDERS EQUITY

(In thousands)



|                                                             |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   |         |  
|------------------------------------------------------------ |  | ------------ |  | ------------------------ | --- |  | ------------------------------------------ | ------- | - | -------------------- | - | ---- | ------------------ |  | - | ------------------------ | - |  | - | -------- | - |  | - | ------- | -
|                                                             |  | Common Stock |  | AdditionalPaid-inCapital |     |  | AccumulatedOtherComprehensiveIncome (loss) |         |   | DeferredCompensation |   |      | AccumulatedDeficit |  |   | TotalStockholdersEquity |  
|                                                             |  | Shares       |  | Amount                   |     |  |                                            |         |  
|Balance as of December 31, 2003                              |  | 52,608       |  | $                        | 53  |  | $                                          | 126,805 |   |                      | $ | 1    |                    |  | $ |                         |   |  | $ | (106,272 | ) |  | $ | 20,587  |  
|Comprehensive loss:                                          |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   |         |  
|Net loss                                                     |  |             |  |                          |    |  |                                            |        |   |                      |   |     |                    |  |   |                         |   |  |   | (81,430  | ) |  |   | (81,430 | )
|Changes in unrealized loss on securities available-for-sale  |  |             |  |                          |    |  |                                            |        |   |                      |   | (58  | )                  |  |   |                         |   |  |   |         |   |  |   | (58     | )
|                                                             |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   |         |  
|Comprehensive loss                                           |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   | (81,488 | )
|Exercise of warrants                                         |  | 819          |  |                          | 1   |  |                                            | 26      |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | 27      |  
|Merger with ACLARA                                           |  | 61,887       |  |                          | 62  |  |                                            | 129,489 |   |                      |   |     |                    |  |   | (299                     | ) |  |   |         |   |  |   | 129,252 |  
|Conversion of Series A and C Preferred Stock to common stock |  | 233          |  |                          |    |  |                                            | 184     |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | 184     |  
|Amortization of deferred compensation                        |  |             |  |                          |    |  |                                            |        |   |                      |   |     |                    |  |   | 24                       |   |  |   |         |   |  |   | 24      |  
|Issuance of common stock                                     |  | 364          |  |                          |    |  |                                            | 596     |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | 596     |  
|Stock-based compensation                                     |  |             |  |                          |    |  |                                            | 3,512   |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | 3,512   |  
|Preferred stock dividends                                    |  | 124          |  |                          |    |  |                                            | (21     | ) |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | (21     | )
|                                                             |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   |         |  
|Balance as of December 31, 2004                              |  | 116,035      |  |                          | 116 |  |                                            | 260,591 |   |                      |   | (57  | )                  |  |   | (275                     | ) |  |   | (187,702 | ) |  |   | 72,673  |  
|Comprehensive loss:                                          |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   |         |  
|Net loss                                                     |  |             |  |                          |    |  |                                            |        |   |                      |   |     |                    |  |   |                         |   |  |   | (37,586  | ) |  |   | (37,586 | )
|Changes in unrealized loss on securities available-for-sale  |  |             |  |                          |    |  |                                            |        |   |                      |   | (457 | )                  |  |   |                         |   |  |   |         |   |  |   | (457    | )
|                                                             |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   |         |  
|Comprehensive loss                                           |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   | (38,043 | )
|Exercise of warrants                                         |  | 7,740        |  |                          | 8   |  |                                            | 5,756   |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | 5,764   |  
|Conversion of Series A Preferred Stock to common stock       |  | 2,243        |  |                          | 2   |  |                                            | 1,808   |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | 1,810   |  
|Amortization of deferred compensation, net of forfeitures    |  |             |  |                          |    |  |                                            | (5      | ) |                      |   |     |                    |  |   | 194                      |   |  |   |         |   |  |   | 189     |  
|Issuance of common stock                                     |  | 1,483        |  |                          | 2   |  |                                            | 2,309   |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | 2,311   |  
|Stock-based compensation                                     |  |             |  |                          |    |  |                                            | (3,051  | ) |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | (3,051  | )
|Preferred stock dividends                                    |  | 167          |  |                          |    |  |                                            | 118     |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | 118     |  
|                                                             |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   |         |  
|Balance as of December 31, 2005                              |  | 127,668      |  |                          | 128 |  |                                            | 267,526 |   |                      |   | (514 | )                  |  |   | (81                      | ) |  |   | (225,288 | ) |  |   | 41,771  |  
|Comprehensive loss:                                          |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   |         |  
|Net loss                                                     |  |             |  |                          |    |  |                                            |        |   |                      |   |     |                    |  |   |                         |   |  |   | (38,703  | ) |  |   | (38,703 | )
|Changes in unrealized loss on securities available-for-sale  |  |             |  |                          |    |  |                                            |        |   |                      |   | 390  |                    |  |   |                         |   |  |   |         |   |  |   | 390     |  
|                                                             |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   |         |  
|Comprehensive loss                                           |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   | (38,313 | )
|Exercise of warrants                                         |  | 460          |  |                          |    |  |                                            |        |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   |        |  
|Reclassification of deferred compensation                    |  |             |  |                          |    |  |                                            | (81     | ) |                      |   |     |                    |  |   | 81                       |   |  |   |         |   |  |   |        |  
|Issuance of common stock                                     |  | 2,983        |  |                          | 3   |  |                                            | 4,068   |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | 4,071   |  
|Stock-based compensation under SFAS 123R                     |  |             |  |                          |    |  |                                            | 6,103   |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | 6,103   |  
|Convertible promissory note interest payment                 |  | 196          |  |                          |    |  |                                            | 276     |   |                      |   |     |                    |  |   |                         |   |  |   |         |   |  |   | 276     |  
|                                                             |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   |         |  
|Balance as of December 31, 2006                              |  | 131,307      |  | $                        | 131 |  | $                                          | 277,892 |   |                      | $ | (124 | )                  |  | $ |                         |   |  | $ | (263,991 | ) |  | $ | 13,908  |  
|                                                             |  |              |  |                          |     |  |                                            |         |   |                      |   |      |                    |  |   |                          |   |  |   |          |   |  |   |         |  

The accompanying notes are an integral part of the financial statements.



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MONOGRAM BIOSCIENCES, INC.

STATEMENTS OF CASH FLOWS

(In thousands)



|                                                                            |  |                         |         |   |      |   |         |      |  |   |         |  
|--------------------------------------------------------------------------- |  | ----------------------- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | -
|                                                                            |  | Year Ended December 31, |        
|                                                                            |  | 2006                    |         |   | 2005 |   |         | 2004 | 
|OPERATING ACTIVITIES:                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Net loss                                                                    |  | $                       | (38,703 | ) |      | $ | (37,586 | )    |  | $ | (81,430 | )
|Adjustments to reconcile net loss to net cash used in operating activities: |  |                         |         |   |      |   |         |      |  |   |         |  
|Contingent value rights revaluation                                         |  |                         | 17,248  |   |      |   | 27,407  |      |  |   | (28,505 | )
|In-process research and development                                         |  |                         |        |   |      |   |        |      |  |   | 100,600 |  
|Depreciation and amortization                                               |  |                         | 3,905   |   |      |   | 3,320   |      |  |   | 2,703   |  
|Stock-based compensation expense under SFAS 123R                            |  |                         | 6,102   |   |      |   |        |      |  |   |        |  
|Stock-based compensation expense (adjustment) under APB 25                  |  |                         |        |   |      |   | (2,862  | )    |  |   | 3,536   |  
|Provision for doubtful accounts                                             |  |                         | 357     |   |      |   | 826     |      |  |   | 319     |  
|Loss on disposal of property and equipment                                  |  |                         |        |   |      |   | 20      |      |  |   | 178     |  
|Change in assets and liabilities:                                           |  |                         |         |   |      |   |         |      |  |   |         |  
|Accounts receivable                                                         |  |                         | 1,857   |   |      |   | (2,638  | )    |  |   | (1,180  | )
|Prepaid expenses                                                            |  |                         | (127    | ) |      |   | (269    | )    |  |   | 66      |  
|Inventory                                                                   |  |                         | 209     |   |      |   | (111    | )    |  |   | 393     |  
|Other current assets                                                        |  |                         | 412     |   |      |   | (206    | )    |  |   | 7       |  
|Accounts payable                                                            |  |                         | (480    | ) |      |   | (1,313  | )    |  |   | (348    | )
|Accrued compensation                                                        |  |                         | (13     | ) |      |   | 574     |      |  |   | 405     |  
|Accrued liabilities                                                         |  |                         | 659     |   |      |   | 1,772   |      |  |   | 333     |  
|Accrued restructuring costs                                                 |  |                         | (1,337  | ) |      |   | (2,541  | )    |  |   | 175     |  
|Deferred revenue                                                            |  |                         | 21      |   |      |   | (163    | )    |  |   | 170     |  
|Contingent value rights revaluation payment                                 |  |                         | (14,324 | ) |      |   |        |      |  |   |        |  
|Other long-term liabilities                                                 |  |                         | 36      |   |      |   | 24      |      |  |   | (49     | )
|                                                                            |  |                         |         |   |      |   |         |      |  |   |         |  
|Net cash used in operating activities                                       |  |                         | (24,178 | ) |      |   | (13,746 | )    |  |   | (2,627  | )
|                                                                            |  |                         |         |   |      |   |         |      |  |   |         |  
|INVESTING ACTIVITIES:                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Purchases of short-term investments                                         |  |                         | (15,066 | ) |      |   | (34,454 | )    |  |   | (8      | )
|Maturities and sales of short-term investments                              |  |                         | 49,987  |   |      |   | 49,420  |      |  |   | 394     |  
|Capital expenditures                                                        |  |                         | (1,781  | ) |      |   | (3,241  | )    |  |   | (749    | )
|Restricted cash                                                             |  |                         | 50      |   |      |   | 300     |      |  |   | 319     |  
|Acquisition of ACLARA, net of cash assumed                                  |  |                         |        |   |      |   |        |      |  |   | (220    | )
|Transaction costs related to merger                                         |  |                         |        |   |      |   | (4,689  | )    |  |   |        |  
|Other assets                                                                |  |                         | (150    | ) |      |   | 77      |      |  |   | (432    | )
|                                                                            |  |                         |         |   |      |   |         |      |  |   |         |  
|Net cash provided by (used in) investing activities                         |  |                         | 33,040  |   |      |   | 7,413   |      |  |   | (696    | )
|                                                                            |  |                         |         |   |      |   |         |      |  |   |         |  
|FINANCING ACTIVITIES:                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Proceeds from loans payable                                                 |  |                         | 6,325   |   |      |   | 712     |      |  |   | 548     |  
|Proceeds from convertible promissory note                                   |  |                         | 25,000  |   |      |   |        |      |  |   |        |  
|Principal payments on loans payable and capital lease obligations           |  |                         | (1,101  | ) |      |   | (865    | )    |  |   | (714    | )
|Proceeds from issuance of common stock                                      |  |                         | 4,348   |   |      |   | 8,075   |      |  |   | 623     |  
|Contingent value right payment                                              |  |                         | (42,787 | ) |      |   |        |      |  |   |        |  
|                                                                            |  |                         |         |   |      |   |         |      |  |   |         |  
|Net cash provided by (used in) financing activities                         |  |                         | (8,215  | ) |      |   | 7,922   |      |  |   | 457     |  
|                                                                            |  |                         |         |   |      |   |         |      |  |   |         |  
|Net increase (decrease) in cash and cash equivalents                        |  |                         | 647     |   |      |   | 1,589   |      |  |   | (2,866  | )
|Cash and cash equivalents at the beginning of the period                    |  |                         | 7,616   |   |      |   | 6,027   |      |  |   | 8,893   |  
|                                                                            |  |                         |         |   |      |   |         |      |  |   |         |  
|Cash and cash equivalents at the end of the period                          |  | $                       | 8,263   |   |      | $ | 7,616   |      |  | $ | 6,027   |  
|                                                                            |  |                         |         |   |      |   |         |      |  |   |         |  
|SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION                            |  |                         |         |   |      |   |         |      |  |   |         |  
|Cash paid for interest                                                      |  | $                       | 129     |   |      | $ | 60      |      |  | $ | 34      |  
|SCHEDULE OF NONCASH FINANCING AND INVESTING ACTIVITIES                      |  |                         |         |   |      |   |         |      |  |   |         |  
|Convertible promissory note interest payment                                |  | $                       | 276     |   |      | $ |        |      |  | $ |        |  
|Preferred stock converted into common shares                                |  | $                       |        |   |      | $ | 1,810   |      |  | $ | 184     |  
|Assets acquired under capital leases                                        |  | $                       |        |   |      | $ | 310     |      |  | $ |        |  
|Accrued transaction costs                                                   |  | $                       |        |   |      | $ |        |      |  | $ | 2,116   |  
|Stock dividend to preferred stockholders                                    |  | $                       |        |   |      | $ | 118     |      |  | $ | 302     |  

The accompanying notes are an integral part of the financial statements.



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS

December 31, 2006

1. SUMMARY OF SIGNIFICANT
ACCOUNTING POLICIES

Organization and Basis of Presentation

Monogram Biosciences, or the Company, is a life sciences company committed to advancing personalized medicine and improving patient outcomes through the development of innovative molecular diagnostics products that
guide and target the most appropriate treatments. Through a comprehensive understanding of genetics, biology and pathology of particular diseases, Monogram Biosciences has pioneered and are developing molecular diagnostics and laboratory services
that are designed to:



| |  |  | enable physicians to better manage infectious diseases and cancers by providing the critical information that helps them prescribe personalized treatments for
patients by matching the underlying molecular features of an individual patients disease to the drug expected to have maximal therapeutic benefit; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | enable pharmaceutical companies to develop new and improved anti-viral therapeutics and targeted cancer therapeutics more efficiently and cost effectively by
providing enhanced patient selection and monitoring capabilities throughout the development process.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Over the last
several years, Monogram Biosciences has built a business based on the personalized medicine approach in HIV drug resistance testing. With the Companys merger with ACLARA BioSciences, Inc., (ACLARA) in December 2004, the Company
intends to leverage the experience and infrastructure it has built in the HIV market to the substantially larger market opportunity of cancer utilizing the proprietary eTag technology. Monogram Biosciences was incorporated in the state of
Delaware in November 1995 and commenced commercial operations in 1999.

Use of Estimates

The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions
that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates.

Fair Value of
Financial Instruments

The carrying value of cash and cash equivalents, short-term investments, accounts receivable, accounts payable,
other accrued expenses and short-term obligations approximates fair value based on the highly liquid, short-term nature of these instruments.

Cash
Equivalents

The Company considers all highly liquid investments with original maturities of three months or less from the date of
purchase to be cash equivalents. Management determines the appropriate classification of its cash equivalents and investment securities at the time of purchase and reevaluates such determination as of each balance sheet date.

Short-Term Investments

Available-for-sale securities
are carried at fair value, with the unrealized gains and losses reported in comprehensive income (loss). The amortized cost of debt securities in this category is adjusted for amortization



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



of premiums and accretion of discounts to maturity. Such amortization is included in interest income. Realized gains and losses and declines in value judged
to be other-than-temporary, if any, on available-for-sale securities are included in other income or expense. The cost of securities sold is based on the specific identification method. Interest and dividends on securities classified as
available-for-sale are included in interest income.

Significant Concentrations

The Company invests its cash, cash equivalents and short-term investments in U.S. government and agency securities, debt instruments of financial
institutions and corporations, and money market funds with strong credit ratings. Pursuant to the Companys investment guidelines, the investment portfolio should have an overall weighted-average maturity of less than 12 months with no one
individual security having a maturity of greater than 24 months. Management believes that its investment guidelines limit credit risk and maintain liquidity.

The Company has significant customer concentration and the loss of any major customer or the reduced use of its products by a major customer could have a significant negative impact on the Companys revenue. In
2006, 2005 and 2004, approximately 21%, 22% and 31%, respectively of the Companys revenues were derived from tests performed for the beneficiaries of the Medicare and Medicaid programs. Additionally, in 2006, 2005 and 2004, Pfizer Inc.
represented approximately 19%, 19% and 7%, Quest Diagnostics Incorporated represented approximately 11%, 11% and 12% and GlaxoSmithKline represented approximately 6%, 10% and 4% of our total revenue, respectively. Gross accounts receivable balances
from Medicare and Medicaid represented 27% and 33% of gross accounts receivable balance at December 31, 2006 and 2005, respectively.

The Company purchases various testing materials from single qualified suppliers. Any extended interruption in the supply of these materials could result in the Companys inability to secure sufficient materials to conduct business and
meet customer demand.

Inventory

Inventory is stated at the lower of standard cost, which approximates actual cost on a first-in, first-out basis, or market. If inventory costs exceed expected market value due to obsolescence or lack of demand, reserves are recorded for
the difference between the cost and the market value. These reserves are based on estimates. Inventory consists of the following:



|                |  |                |     |      |   |      
|--------------- |  | -------------- | --- | ---- | - | -----
|                |  | December 31,  
|                |  | 2006           |     | 2005
|                |  | (In thousands)
|Raw materials   |  | $              | 685 |      | $ | 698  
|Work in process |  |                | 276 |      |   | 472  
|                |  |                |     |      |   |      
|Total           |  | $              | 961 |      | $ | 1,170
|                |  |                |     |      |   |      

Property and Equipment

Property and equipment are recorded at cost and are depreciated using the straight-line method over the estimated useful lives of the assets, generally five years. Capitalized software includes software and external
consulting costs incurred to implement new information systems. Computer hardware and capitalized software are depreciated over three to five years. Leasehold improvements are amortized over the shorter of the estimated useful life of the assets or
the lease term.



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



Accounting for Merger with ACLARA

The Company accounted for the merger with ACLARA, which closed in December 2004, as a business combination which requires that the assets acquired and
liabilities assumed be recorded at the date of acquisition at their respective fair values. The judgments made in determining the estimated fair value assigned to each class of assets acquired and liabilities assumed, as well as asset lives, can
materially impact our results of operations. Accordingly, for significant items, the Company obtained assistance from independent valuation specialists.

For intangible assets, including purchased in-process research and development (IPR&D), the Company utilized the income method to determine fair value of the purchased IPR&D. This method starts
with a forecast of anticipated future net cash flows, which are then adjusted to present value by applying an appropriate discount rate that reflects the risk factors associated with the cash flow streams. Some of the more significant estimates and
assumptions include the amount and timing of projected cash flows; expected costs to develop IPR&D into commercially viable products and estimates of cash flows from the projects when completed; the expected useful lives of technologies and
products; and the discount rate reflecting the inherent risks in the future cash flows. All of these judgments and estimates can materially impact results of operations.

The excess of the aggregate purchase consideration over the fair value of assets acquired and liabilities assumed has been allocated to goodwill. Future adjustments to these estimates will be recorded in the
Companys results of operations.

Contingent Value Rights

As part of the merger with ACLARA BioSciences, Inc. (ACLARA), the Company issued Contingent Value Rights (CVR) to ACLARA stockholders and was obligated to issue CVRs to holders of assumed
ACLARA stock options upon future exercise of those options. In June 2006, the amount payable related to the outstanding CVRs was determined at $0.88 per CVR and a cash payment of approximately $57.0 million was made to CVR holders on June 14,
2006. Holders of assumed ACLARA options are entitled to receive a cash payment of $0.88, upon future exercise of those options, for each CVR that would have been issuable to them had the option been exercised prior to the CVR maturity date.

The liability under the CVRs was recorded at the closing of the merger with ACLARA at fair value, estimated using a calculation based on a
Black-Scholes valuation of the underlying CVR securities of $0.66 per CVR. Subsequent to the closing of the merger and through June 14, 2006, an active trading market had been established and as a result, this liability was revalued based on
the actual closing price of the CVRs on the OTC Bulletin Board at the end of each quarter. In addition, the Company records an additional liability each quarter for additional CVRs related to assumed ACLARA stock options as they vest during each
quarter.

Goodwill, Other Intangible Assets and Impairment of Long-Lived Assets

Goodwill represents the excess of the purchase consideration over the fair values of the identifiable assets acquired and liabilities assumed from the
Companys merger with ACLARA. Goodwill is not amortized but, in accordance with Statement of Financial Accounting Standards No. 142 Goodwill and Other Intangible Assets (SFAS 142), the Company tests for impairment
of goodwill on an annual basis and at any other time if events occur or circumstances indicate that the carrying amount of goodwill may not be recoverable.

Other intangible assets include acquired developed product technology, costs of patents and patent applications related to products and products in development, which are capitalized and amortized on a straight-



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



line basis over their estimated useful lives. Circumstances that could trigger an impairment test include but are not limited to: a significant adverse
change in the business or legal factors; an adverse action or assessment by a regulator; unanticipated competition or loss of key personnel.

Revenue
Recognition

Product revenue is recognized upon completion of tests made on samples provided by customers and the shipment of test
results to those customers. Services are provided to certain patients covered by various third-party payor programs, such as Medicare and Medicaid. Billings for services under third-party payor programs are included in revenue net of allowances for
differences between the amounts billed and estimated receipts under such programs. The Company estimates these allowances based on historical payment information and current sales data. If the government and other third-party payors significantly
change their reimbursement policies, an adjustment to the allowance may be necessary. Revenue generated from our database of resistance test results is recognized when earned under the terms of the related agreements, generally upon shipment of the
requested reports. Contract revenue consists of revenue generated from NIH grants, commercial assay development and other non-product revenue. NIH grant revenue is recorded on a reimbursement basis as grant costs are incurred. The costs associated
with contract revenue are included in research and development expenses. For commercial and research collaborations, the Company recognizes non-refundable milestone payments received related to substantive at-risk milestones when performance of the
milestone under the terms of the collaboration is achieved and there are no further performance obligations. Research and development fees from commercial collaboration agreements are generally recognized as revenue on a straight-line basis over the
life of the collaboration agreement or as the research work is performed. Up front payments received in advance of meeting the revenue recognition criteria described above are deferred.

In accordance with Emerging Issues Task Force Issue No. 00-21, Revenue Arrangements with Multiple Deliverables, (EITF 00-21)
revenue arrangements entered into after June 15, 2003, that include multiple element arrangements are analyzed to determine whether the deliverables are divided into separate units of accounting or as a single unit of accounting. Revenues are
allocated to a delivered product or service when all of the following criteria are met: (1) the delivered item has value to the customer on a standalone basis; (2) there is objective and reliable evidence of the fair value of the
undelivered item; and (3) if the arrangement includes a general right of return relative to the delivered item, delivery or performance of the undelivered item is considered probable and substantially in our control. If all of the three
required criteria under EITF 00-21 are met, then the deliverables would be accounted for separately, completed as performed. Otherwise, the arrangement would be accounted for as a single unit of accounting and the payments for performance
obligations are recognized as revenue over the estimated period of when the performance obligations are performed. If the Company cannot reasonably estimate when our performance obligation either ceases or becomes inconsequential, then revenue is
deferred until the Company can reasonably estimate when the performance obligation ceases or becomes inconsequential.

Accounts Receivable

The process for estimating the collectibility of receivables involves significant assumptions and judgments. Billings for services
under third-party payor programs are recorded as revenue net of allowances for differences between amounts billed and the estimated receipts under such programs. Adjustments to the estimated receipts, based on final settlement with the third-party
payors, are recorded upon settlement as an adjustment to net revenue. In addition, the Company reviews and estimates the collectibility of receivables based on the period of time such receivables have been outstanding. Historical collection and
payor reimbursement experience is an



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



integral part of the estimation process related to the allowance for doubtful accounts. Adjustments to the allowance for doubtful accounts estimate are
included in general and administrative expenses. The Company writes off accounts against the allowance for doubtful accounts when they are deemed to be uncollectible.

Research and Development

The Company expenses research and development costs as incurred. Research
and development expenses consist primarily of salaries and related personnel costs, materials, supply costs for prototypes, and include costs associated with contract revenue. In addition, research and development expenses include costs related to
clinical trials and validation of the Companys testing processes and procedures and related overhead expenses.

Advertising Expenses

The Company expenses the costs of advertising, which include promotional expenses, as incurred. Advertising expenses were $4.7 million,
$4.0 million and $2.5 million for the years ended December 31, 2006, 2005 and 2004, respectively, and were recorded as sales and marketing expenses.

Loss Per Common Share

Basic loss per common share is calculated based on the weighted-average number of common shares
outstanding during the periods presented. Diluted loss per common share would give effect to the dilutive impact of potential common shares which consists of convertible preferred stock (using the as-if converted method), and stock options and
warrants (using the treasury stock method). Potentially dilutive securities have been excluded from the diluted loss per common share computations in all years presented as such securities have an anti-dilutive effect on loss per common share due to
the Companys net loss.

The following outstanding options and warrants, prior to the application of the treasury stock method, and
convertible preferred stock, on an as-converted basis, were excluded from the computation of diluted loss per common share as these potentially dilutive securities had an anti-dilutive effect:



|                                                                        |  |                |  |        |  |       
|----------------------------------------------------------------------- |  | -------------- |  | ------ |  | ------
|                                                                        |  | December 31,  
|                                                                        |  | 2006           |  | 2005   |  | 2004  
|                                                                        |  | (In thousands)
|Series A redeemable convertible preferred stock (as-if Converted basis) |  |               |  |       |  | 2,243 
|Convertible promissory note (as if converted basis)                     |  | 9,243          |  |       |  |      
|Outstanding warrants                                                    |  | 819            |  | 2,358  |  | 12,134
|Outstanding stock options                                               |  | 19,211         |  | 18,341 |  | 12,941

Stock-Based Compensation

Effective January 1, 2006, the Company adopted Statement of Financial Accounting Standards No. 123R Share Based Payment (SFAS 123R) under provisions of Staff Accounting Bulletin
No. 107 (SAB 107) using the modified prospective approach and therefore has not restated results for prior periods. Under this approach, share-based compensation cost is measured at the grant date, based on the estimated fair value
of the award. Pursuant to the provisions of SFAS 123R, the Company records stock-based compensation as a charge to earnings net of the estimated impact of forfeited awards. As such, the Company recognized stock-based compensation cost only for those
stock-based awards that are estimated to ultimately vest over their requisite



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



service period, based on the vesting provisions of the individual grants. The Company has no awards with market or performance conditions.

On November 10, 2005, the Financial Accounting Standards Board, or FASB, issued FASB Staff Position No. FAS 123R-3, Transition Election
Related to Accounting for Tax Effects of Share-Based Payment Awards. The Company has elected to adopt the alternative transition method provided in this FASB Staff Position for calculating the tax effects of share-based compensation pursuant
to SFAS 123R. The alternative transition method includes a simplified method to establish the beginning balance of the additional paid-in capital pool related to the tax effects of employee share-based compensation, which is available to absorb tax
deficiencies recognized subsequent to the adoption of SFAS 123R. There was no tax benefit realized upon exercise of stock options in 2006.

The Company uses the Black-Scholes option-pricing valuation model to estimate the grant date fair value of its stock-based awards in accordance with SFAS 123R and SAB 107. The determination of fair value for stock-based awards on the date
of grant using an option-pricing model requires management to make certain assumptions regarding: (i) the expected volatility in the market price of the Companys common stock over the expected term of the awards; (ii) dividend yield;
(iii) risk-free interest rates; and (iv) actual and projected employee exercise behaviors (referred to as the expected term). The expected volatility is based on the historical volatilities of our stock for the expected term in effect on
the date of grant with considerations to similar public entities in similar markets. The risk-free interest rate is based on the U.S. Zero Coupon Treasury yield for the expected term in effect on the date of grant. The expected term of options
represents the period of time that options granted are expected to be outstanding and is derived from actual historical exercise data with considerations to the contractual and vesting terms. The expected term of employee stock purchase plans is
equal to the offering period. In addition, SFAS 123R requires the Company to estimate the expected impact of forfeited awards and recognize stock-based compensation cost only for those awards expected to vest. The cumulative effect on current and
prior periods of a change in the estimated forfeiture rate is recognized as compensation expense in the period of the revision. In 2006 forfeitures were estimated to be approximately 2% over the expected term, based on historical experience. If
actual forfeiture rates are materially different from estimates or factors change and we employ different assumptions, future stock-based compensation expense could be significantly different from what the Company has recorded in the current period.
Management periodically reviews actual forfeiture experience and revises estimates, as considered necessary.

The weighted-average
estimated fair value of options granted during 2006 has been estimated at the date of grant using the Black-Scholes option-pricing model with the following assumptions: risk-free interest rate from 4.6% to 4.9%; weighted-average expected term of
stock options from grant date from 5.8 years to 6.1 years; volatility factor from 76% to 88%; and a dividend yield of zero. The weighted-average per share grant date fair value of stock options granted to employees in 2006 was $1.20. The total fair
value of stock options vested in 2006 was $6.7 million.

The fair value of employee stock purchases in 2006 is based on an offering period
starting December 1, 2005 which has been estimated using the Black-Scholes option-pricing model with the following assumptions: risk-free interest rate from 4.3% to 4.4%; expected term from 0.5 year to 2.0 years; volatility factor from 40% to
52%; and a dividend yield of zero.



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



Stock-based compensation expenses related to stock options and employee stock purchases recognized
under SFAS 123R were as follows:



|                         |  |                             |      
|------------------------ |  | --------------------------- | -----
|                         |  | Year endedDecember 31, 2006
|                         |  | (In thousands)             
|Cost of product revenue  |  | $                           | 597  
|Research & development   |  |                             | 1,640
|Sales & marketing        |  |                             | 1,421
|General & administrative |  |                             | 2,380
|                         |  |                             |      
|                         |  | $                           | 6,038
|                         |  |                             |      

As of December 31, 2006, the total remaining unrecognized compensation costs related to the
non-vested stock options amounted to $7.6 million which is expected to be recognized over the weighted-average remaining requisite service period of 1.22 years. As of December 31, 2006, the total remaining unrecognized compensation costs
related to employee stock purchases was $0.2 million which is expected to be recognized over the remainder of the two-year offering period that started December 1, 2005.

Pro Forma Information under SFAS 123 for Periods Prior to fiscal 2006

Prior to the adoption of SFAS
123R, the Company accounted for stock-based awards under the intrinsic method of Accounting Principles Board Opinion No. 25, Accounting for Stock Issued to Employees (APB 25) and made pro forma footnote disclosures as
required by Statement of Financial Accounting Standards No. 148, Accounting For Stock-Based CompensationTransition and Disclosure, which amended Statement of Financial Accounting Standards No. 123, Accounting For
Stock-Based Compensation. Under the intrinsic method, no stock-based compensation expense had been recognized in the statements of operations because the exercise price of the stock options granted equaled the fair market value of the
underlying stock on the date of grant. Pro forma net loss and pro forma net loss per share disclosed in the footnotes to the financial statements were estimated using the Black-Scholes option-pricing model.

The fair value of options granted in 2005 had been estimated at the date of grant using the Black-Scholes option-pricing model with the following
assumptions: risk-free interest rate from 3.7% to 4.4%; weighted-average expected term of stock options from grant date of 6.1 years; volatility factor of 88%; and a dividend yield of zero. The weighted-average grant date fair value of stock options
granted to employees in 2005 was $1.73. The total fair value of stock options vested in 2005 was $5.6 million.

The fair value of employee
stock purchases in 2005 was based on an offering period starting December 1, 2004 which had been estimated using the Black-Scholes option-pricing model with the following assumptions: risk-free interest rate from 2.4% to 3.0%; expected term
from 0.5 year to 2.0 years; volatility factor from 50% to 78%; and a dividend yield of zero.



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



The following table provides the Companys pro forma information as if the fair value method had
been applied to the stock-based compensation calculation:



|                                                                               |  |                                       |         |   |      |   |         |  
|------------------------------------------------------------------------------ |  | ------------------------------------- | ------- | - | ---- | - | ------- | -
|                                                                               |  | Year Ended December 31,               |        
|                                                                               |  | 2005                                  |         |   | 2004 |  
|                                                                               |  | (In thousands, except per share data) |        
|Net loss:                                                                      |  |                                       |         |   |      |   |         |  
|As reported                                                                    |  | $                                     | (37,586 | ) |      | $ | (81,430 | )
|Adjustments:                                                                   |  |                                       |         |   |      |   |         |  
|Stock-based compensation expense (adjustment) included in reported net loss    |  |                                       | (2,914  | ) |      |   | 3,408   |  
|Stock-based compensation expense for employee awards determined under SFAS 123 |  |                                       | (3,661  | ) |      |   | (3,645  | )
|                                                                               |  |                                       |         |   |      |   |         |  
|Pro forma net loss                                                             |  |                                       | (44,161 | ) |      |   | (81,667 | )
|Preferred stock dividend                                                       |  |                                       | (162    | ) |      |   | (324    | )
|                                                                               |  |                                       |         |   |      |   |         |  
|Pro forma loss applicable to common stockholders                               |  | $                                     | (44,323 | ) |      | $ | (81,991 | )
|                                                                               |  |                                       |         |   |      |   |         |  
|Loss per common share:                                                         |  |                                       |         |   |      |   |         |  
|As reported                                                                    |  | $                                     | (0.31   | ) |      | $ | (1.43   | )
|                                                                               |  |                                       |         |   |      |   |         |  
|Pro forma                                                                      |  | $                                     | (0.36   | ) |      | $ | (1.43   | )
|                                                                               |  |                                       |         |   |      |   |         |  

The Company accounts for stock option grants to non-employees in accordance with the Emerging
Issues Task Force Consensus No. 96-18, Accounting for Equity Instruments That Are Issued to Other Than Employees for Acquiring, or in Conjunction with Selling, Goods or Services, which requires the options subject to vesting to be
periodically re-valued over their service periods, which approximates the vesting period. The impact of these options has not been material.

Comprehensive Income (Loss)

Comprehensive income (loss) is comprised of net loss and other comprehensive income (loss).
Other comprehensive income (loss) includes certain changes in equity that are excluded from net income (loss). Specifically, unrealized gains and losses on our available-for-sale securities, which are reported separately in stockholders
equity, are included in accumulated other comprehensive income (loss).

Segment Reporting

The Company currently operates in a single business segment as there is only one measurement of profit (loss) for its operations. As of December 31,
2006, all of our long-lived assets are located in the United States.

Recent Accounting Pronouncements

In February 2006, the Financial Accounting Standards Board (FASB) issued SFAS No. 155, Accounting for Certain Hybrid Financial
Instruments (SFAS 155). SFAS No. 155 amends SFAS No. 133 Accounting for Derivative Instruments and Hedging Activities, and SFAS No. 140 Accounting for Transfers and Servicing of
Financial Assets and Extinguishments of Liabilities and addresses the application of SFAS No. 133 to beneficial interests in securitized financial assets. SFAS No. 155 establishes a requirement to evaluate interests in
securitized financial assets to identify interests that are freestanding derivatives or that are hybrid financial



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



instruments that contain an embedded derivative requiring bifurcation. Additionally, SFAS No. 155 permits fair value measurement for any hybrid
financial instrument that contains an embedded derivative that otherwise would require bifurcation. SFAS No. 155 is effective for fiscal years beginning after September 15, 2006. The Company is currently evaluating the impact of
adopting SFAS 155 on its financial statements.

In July 2006, the Financial Accounting Standards Board (FASB) issued FASB
Interpretation No. 48, Accounting for Uncertainty in Income Taxes, an interpretation of FASB Statement No. 109 (FIN 48). FIN 48 clarifies the accounting for uncertainty in income taxes by prescribing the
recognition threshold a tax position is required to meet before being recognized in the financial statements. It also provides guidance on derecognition, classification, interest and penalties, accounting in interim periods, disclosure, and
transition. FIN 48 is effective for fiscal years beginning after December 15, 2006 and is required to be adopted by us in 2007. The Company is currently evaluating the impact of adopting FIN 48 on its financial statements.

In September 2006, the FASB issued statement No. 157, Fair value Measurements (SFAS 157). This standard establishes the
framework for measuring fair value and expands the disclosure requirement for fair value measurements. SFAS 157 is effective for fiscal years beginning after November 15, 2007. The Company is currently evaluating the impact of adopting
SFAS 157 on its financial statements.

In September 2006, the Securities and Exchange Commission issued Staff Accounting Bulletin
No. 108 (SAB 108) that provides guidance on the process of quantifying financial statement misstatements. This bulletin is effective for any interim period of the first fiscal year ending after November 15, 2006. The adoption
of SAB 108 did not have a significant effect on its financial statements.

In February 2007, the FASB issued SFAS No. 159,
The Fair Value Option for Financial Assets and Financial Liabilities (SFAS 159) which permits entities to choose to measure many financial instruments and certain other items at fair value that are not currently required
to be measured at fair value. SFAS 159 is effective for fiscal years beginning after November 15, 2007. The Company is currently evaluating the impact of adopting SFAS 159 on its financial statements.

2. SHORT-TERM INVESTMENTS

The amortized cost, gross
unrealized gains and losses, and estimated fair value for available-for-sale securities by major security type and class of security are as follows:



|                                        |  |                |        |                            |   |      |                     |  |               |        |                            |   |        |                     |   |      |   |  |   |       
|--------------------------------------- |  | -------------- | ------ | -------------------------- | - | ---- | ------------------- |  | ------------- | ------ | -------------------------- | - | ------ | ------------------- | - | ---- | - |  | - | ------
|                                        |  | December 31,  
|                                        |  | 2006           |        | 2005                      
|                                        |  | AmortizedCost  |        | GrossUnrealizedHoldingLoss |   |      | EstimatedFair Value |  | AmortizedCost |        | GrossUnrealizedHoldingLoss |   |        | EstimatedFair Value
|                                        |  | (In thousands)
|Maturing within two years:              |  |                |        |                            |   |      |                     |  |               |        |                            |   |        |                     |   |      |   |  |   |       
|Bonds of US government and its agencies |  | $              | 22,991 |                            | $ | (124 | )                   |  | $             | 22,867 |                            | $ | 57,912 |                     | $ | (514 | ) |  | $ | 57,398
|                                        |  |                |        |                            |   |      |                     |  |               |        |                            |   |        |                     |   |      |   |  |   |       

As of December 31, 2006 and 2005, the Company had $22.9 million and $32.5 million,
respectively, of marketable securities at estimated fair value that were in a continuous unrealized loss position for more than one year, resulting in an unrealized loss of $0.1 million and $0.4 million, respectively.



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



3. PROPERTY AND EQUIPMENT

Property and equipment consists of the following:



|                                               |  |                |         |   |      |   |         |  
|---------------------------------------------- |  | -------------- | ------- | - | ---- | - | ------- | -
|                                               |  | December 31,   |        
|                                               |  | 2006           |         |   | 2005 |  
|                                               |  | (In thousands) |        
|Machinery, equipment and furniture             |  | $              | 15,500  |   |      | $ | 14,005  |  
|Equipment under capital lease                  |  |                | 375     |   |      |   | 375     |  
|Leasehold improvements                         |  |                | 7,572   |   |      |   | 7,406   |  
|Capitalized software                           |  |                | 4,349   |   |      |   | 4,306   |  
|                                               |  |                |         |   |      |   |         |  
|                                               |  |                | 27,796  |   |      |   | 26,092  |  
|Less accumulated depreciation and amortization |  |                | (20,333 | ) |      |   | (17,512 | )
|                                               |  |                |         |   |      |   |         |  
|Property and equipment, net                    |  | $              | 7,463   |   |      | $ | 8,580   |  
|                                               |  |                |         |   |      |   |         |  

Depreciation expense was $2.9 million, $3.3 million and $2.7 million in 2006, 2005 and 2004,
respectively. Amortization of assets under capital leases as of December 31, 2006 was $88,000, $88,000 and $13,000 in 2006, 2005 and 2004, respectively. Accumulated amortization of those leased assets was $146,000 and $59,000 at
December 31, 2006 and 2005, respectively.

4. GOODWILL AND OTHER INTANGIBLE ASSETS

Goodwill represents the excess of the purchase consideration over the fair values of the identifiable assets acquired and liabilities assumed from the
Companys merger with ACLARA, which closed in December 2004. Goodwill was $9.9 million at December 31, 2006. The Company tests for impairment of goodwill on an annual basis and at any other time if events occur or circumstances indicate
that the carrying amount of goodwill may not be recoverable.

Measurement of fair value is determined using the income approach. The income
approach focuses on the income-producing capability of an asset, measuring the current value of the asset by calculating the present value of its future economic benefits such as cash earnings, cost savings, tax deductions, and proceeds from
disposition. Value indications are developed by discounting expected cash flows to their present value at a rate of return that incorporates the risk-free rate for the use of funds, the expected rate of inflation and risks associated with the
particular investment. If the carrying amount of goodwill exceeds the implied fair value, an impairment loss is recorded in net income (loss).

Developed product technology represents products that have reached technological feasibility and relates to ACLARAs reagent kits and gene and protein expression assay services that are provided for research applications. Because the
Company is no longer making these kits and services available, these costs were written off and recorded as a research and development expense in December 2005.

Patents, which are included in other assets, represents costs of patents and patent applications related to products and products in development which are capitalized and amortized on a straight-line basis over their
estimated useful lives.



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



Other intangible assets are summarized as follows:



|        |  |                |       |                         |   |        |                               |  |      |     |                         |   |       |                               |   |      |   |  |   |      
|------- |  | -------------- | ----- | ----------------------- | - | ------ | ----------------------------- |  | ---- | --- | ----------------------- | - | ----- | ----------------------------- | - | ---- | - |  | - | -----
|        |  | December 31,  
|        |  | 2006           |       | 2005                   
|        |  | Cost           |       | AccumulatedAmortization |   |        | Net ofAccumulatedAmortization |  | Cost |     | AccumulatedAmortization |   |       | Net ofAccumulatedAmortization
|        |  | (In thousands)
|Patents |  | $              | 2,264 |                         | $ | (1,383 | )                             |  | $    | 881 |                         | $ | 2,095 |                               | $ | (376 | ) |  | $ | 1,719

Amortization expense of other intangible assets was $1.0 million, $0.2 million and $0.1 million in
2006, 2005 and 2004, respectively. The estimated amortization expense related to other intangible assets is approximately $0.5 million each year from 2007 to 2011.

5. ACCRUED LIABILITIES

Accrued liabilities consist of the following:



|                               |  |                |       |      |   |      
|------------------------------ |  | -------------- | ----- | ---- | - | -----
|                               |  | December 31,  
|                               |  | 2006           |       | 2005
|                               |  | (In thousands)
|Accrued royalty                |  | $              | 1,411 |      | $ | 1,131
|Accrued professional fees      |  |                | 988   |      |   | 1,003
|Accrued marketing expenses     |  |                | 577   |      |   | 298  
|Accrued materials and supplies |  |                | 384   |      |   | 647  
|Accrued facilities expenses    |  |                | 238   |      |   | 236  
|Other                          |  |                | 1,122 |      |   | 801  
|                               |  |                |       |      |   |      
|Total accrued liabilities      |  | $              | 4,720 |      | $ | 4,116
|                               |  |                |       |      |   |      

6. MERGER WITH ACLARA BIOSCIENCES, INC.

On December 10, 2004, the Company completed its merger with ACLARA BioSciences, Inc., (ACLARA) a Delaware corporation pursuant to an
Agreement and Plan of Merger and Reorganization dated May 28, 2004 as amended on October 18, 2004 (the Merger Agreement). Under the terms of the Merger Agreement, each outstanding share of ACLARA common stock was exchanged for
1.7 shares of the Companys common stock and 1.7 Contingent Value Rights (CVR). The Company issued 61.9 million shares of common stock valued at $1.94 per share. The fair value of the Companys common stock utilized in
determining the purchase price was derived using the Companys average stock price for the period two days before through two days after the terms of the acquisition were agreed to and announced on October 19, 2004. The CVRs are governed
by a Contingent Value Rights Agreement. The transaction has been accounted for as a business combination and accordingly the assets acquired and liabilities assumed have been recorded at their respective fair values. The Company engaged independent
valuation specialists to assist in determining the fair values of the assets acquired and liabilities assumed. Such a valuation requires management to make significant estimates and assumptions, particularly with regard to the valuation of
intangible assets.



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



The aggregate purchase consideration comprises (in thousands):



|                                                                                       |  |   |        
|-------------------------------------------------------------------------------------- |  | - | -------
|Fair value of common stock issued                                                      |  | $ | 120,308
|Fair value of CVRs related to ACLARA common stock outstanding and vested stock options |  |   | 43,774 
|Fair value of ACLARA stock options assumed                                             |  |   | 9,243  
|Direct transaction costs                                                               |  |   | 4,635  
|                                                                                       |  |   |        
|                                                                                       |  | $ | 177,960
|                                                                                       |  |   |        

The purchase consideration was allocated based on the fair value of the assets acquired, as
follows (in thousands):



|                                                                 |  |   |         |   |  |   |        
|---------------------------------------------------------------- |  | - | ------- | - |  | - | -------
|Tangible assets acquired:                                        |  |   |         |   |  |   |        
|Cash and cash equivalents                                        |  | $ | 2,118   |   |  |   |        
|Short-term investments                                           |  |   | 72,728  |   |  |   |        
|Accounts receivable, inventory and other current assets          |  |   | 827     |   |  |   |        
|Property and equipment                                           |  |   | 2,054   |   |  |   |        
|Other long-term assets                                           |  |   | 100     |   |  |   |        
|Restructuring accrual                                            |  |   | (5,699  | ) |  |   |        
|Other current liabilities                                        |  |   | (4,883  | ) |  |   |        
|Other long-term liabilities                                      |  |   | (311    | ) |  |   |        
|                                                                 |  |   |         |   |  |   |        
|                                                                 |  |   |         |   |  | $ | 66,934 
|Deferred compensation related to unvested ACLARA options assumed |  |   |         |   |  |   | 299    
|Intangible assets acquired:                                      |  |   |         |   |  |   |        
|Developed product technology                                     |  |   | 200     |   |  |   |        
|In-process research and development                              |  |   | 100,600 |   |  |   |        
|Goodwill                                                         |  |   | 9,927   |   |  |   | 110,727
|                                                                 |  |   |         |   |  |   |        
|                                                                 |  |   |         |   |  | $ | 177,960
|                                                                 |  |   |         |   |  |   |        

In connection with the Companys merger with ACLARA, the Company has taken actions to
integrate and restructure the former ACLARA operations. The Company relocated the ACLARA personnel and operations from the facility in Mountain View, California to its South San Francisco, California facilities in the second quarter of 2005. A
restructuring accrual was established for the costs of vacating and subleasing the Mountain View facility including an estimate of the excess of our lease costs over our anticipated sublease income and for the anticipated severance costs for ACLARA
employees whose employment was terminated as a result of the merger. See Restructuring Note 11 below for further discussion.

7. CONTINGENT
VALUE RIGHTS

As part of the merger with ACLARA BioSciences, Inc. (ACLARA), the Company issued Contingent Value Rights
(CVR) to ACLARA stockholders and was obligated to issue CVRs to holders of assumed ACLARA stock options upon future exercise of those options. In June 2006, the amount payable related to the outstanding CVRs was determined at $0.88 per
CVR and a cash payment of approximately $57.0 million was made to CVR holders on June 14, 2006. Holders of assumed ACLARA options are entitled to receive a cash



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



payment of $0.88, upon future exercise of those options, for each CVR that would have been issuable to them had the option been exercised prior to the CVR
maturity date. At December 31, 2006, assumed ACLARA options to purchase 3.3 million shares of the Companys common stock were outstanding, of which 3.1 million shares were vested. The aggregate potential liability related to all
these options at December 31, 2006 was $2.9 million. Of this, $2.7 million is reflected on the balance sheet in current liabilities at December 31, 2006 in respect of options vested and the remainder will be recognized as the options vest
in the future. Upon exercise of these vested options, the Company will receive aggregate exercise proceeds of $6.6 million, offsetting the potential CVR payments of $2.7 million.

The liability under the CVRs was recorded at the closing of the merger with ACLARA at fair value, estimated using a calculation based on a Black-Scholes
valuation of the underlying CVR securities of $0.66 per CVR. Subsequent to the closing of the merger, an active trading market had been established and as a result, this liability was revalued based on the actual closing price of the CVRs on the OTC
Bulletin Board at the end of each quarter. In addition, the Company records an additional liability each quarter for additional CVRs related to assumed ACLARA stock options as they vest during each quarter. The Company recorded $0.8 million and $1.1
million for additional CVRs related to the stock options assumed that vested during the year ended December 31, 2006 and 2005, respectively.

8.
COMMITMENTS AND CONTINGENCIES

At December 31, 2006, the Company leased a building with 41,000 square feet in South San Francisco,
California. The lease expires in April 2010 and provides the Company with an option to extend the term for an additional ten years. In addition, at December 31, 2006, the Company subleased approximately 27,000 square feet in South San
Francisco, California. This sublease expires in December 2007.

As a result of the merger with ACLARA, at December 31, 2004, the
Company assumed the lease for a facility of approximately 44,200 square feet of office and laboratory space in Mountain View, California. The Company also assumed a loan agreement for leasehold improvements at an interest rate of 8.5% per
annum. The loan matures on July 1, 2009 and the amount outstanding at December 31, 2006 was $0.2 million, included in current liabilities. On February 7, 2007, the Company entered into a lease termination agreement with the landlord
to terminate the lease prior to its scheduled expiry. See Note 14 Subsequent Events to the financial statements for further discussion.

In August 2006, the Company entered into a loan agreement of $0.8 million to finance its insurance premiums at an interest rate of 7.84% per annum. The loan was paid in full in January 2007 and the amount outstanding at
December 31, 2006 was $0.4 million included in current liabilities.

In March 2004, the Company terminated a lease for laboratory and
office space of approximately 25,000 square feet in South San Francisco, California. Under the terms of the lease termination agreement, a charge of $0.4 million was recorded and paid primarily related to the termination payment and the write-off of
the net carrying value of the related leasehold improvements.

In June 2002, the Company assigned a lease of excess laboratory and office
space and sold the related leasehold improvements and equipment to a third party. In the event of default by the assignee, the Company would be contractually obligated for payments under the lease of: $0.7 million in 2007; $1.5 million in 2008; $1.6
million in 2009; $1.6 million in 2010 and $0.7 million in 2011.

As of December 31, 2006 and 2005, the Company had amounts outstanding
under equipment financing arrangements, which bear interest at weighted-average fixed rate of approximately 7.9% for 2006 and 2005, and



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



are due in monthly installments through September 2008. The carrying amount of the equipment approximates the corresponding loan balance.

As of December 31, 2006, future minimum payments, excluding the lease assignment guarantee described above, are as follows:



|                                           |  |                     |     |                 |   |              |  |   |                            |   |                                            |   |                                |  |   |       |  |   |      |  
|------------------------------------------ |  | ------------------- | --- | --------------- | - | ------------ |  | - | -------------------------- | - | ------------------------------------------ | - | ------------------------------ |  | - | ----- |  | - | ---- | -
|                                           |  | PurchaseObligations |     | OperatingLeases |   | LoansPayable |  |   | ConvertiblePromissory Note |   | ConvertiblePromissory NoteInterest Payment |   | EquipmentFinancingArrangements | 
|                                           |  | (In thousands)      |    
|Year ending December 31:                   |  |                     |     |                 |   |              |  |   |                            |   |                                            |   |                                |  |   |       |  |   |      |  
|2007                                       |  | $                   | 275 |                 | $ | 2,801        |  | $ | 6,244                      |   |                                            | $ |                               |  | $ | 750   |  | $ | 132  |  
|2008                                       |  |                     |    |                 |   | 1,624        |  |   |                           |   |                                            |   |                               |  |   | 750   |  |   | 95   |  
|2009                                       |  |                     |    |                 |   | 1,353        |  |   |                           |   |                                            |   |                               |  |   | 750   |  |   |     |  
|2010                                       |  |                     |    |                 |   | 355          |  |   |                           |   |                                            |   | 25,000                         |  |   | 473   |  |   |     |  
|                                           |  |                     |     |                 |   |              |  |   |                            |   |                                            |   |                                |  |   |       |  |   |      |  
|Total minimum lease and principal payments |  | $                   | 275 |                 | $ | 6,133        |  |   | 6,244                      |   |                                            |   | 25,000                         |  |   | 2,723 |  |   | 227  |  
|                                           |  |                     |     |                 |   |              |  |   |                            |   |                                            |   |                                |  |   |       |  |   |      |  
|Amount representing interest               |  |                     |     |                 |   |              |  |   | (9                         | ) |                                            |   |                               |  |   |      |  |   | (15  | )
|                                           |  |                     |     |                 |   |              |  |   |                            |   |                                            |   |                                |  |   |       |  |   |      |  
|Present value of future payments           |  |                     |     |                 |   |              |  |   | 6,235                      |   |                                            |   | 25,000                         |  |   | 2,723 |  |   | 212  |  
|Current portion of loans and leases        |  |                     |     |                 |   |              |  |   | (6,235                     | ) |                                            |   |                               |  |   |      |  |   | (120 | )
|                                           |  |                     |     |                 |   |              |  |   |                            |   |                                            |   |                                |  |   |       |  |   |      |  
|Long-term portion                          |  |                     |     |                 |   |              |  | $ |                           |   |                                            | $ | 25,000                         |  | $ | 2,723 |  | $ | 92   |  
|                                           |  |                     |     |                 |   |              |  |   |                            |   |                                            |   |                                |  |   |       |  |   |      |  

Rental expense, was approximately $2.3 million, $2.7 million and $2.0 million in 2006, 2005 and
2004, respectively.

In connection with the merger with ACLARA, the Company issued CVRs to ACLARA stockholders and is obligated to issue
CVRs to holders of assumed ACLARA stock options upon future exercise of those options. See Contingent Value Rights, Note 7 above for further discussion.

Contingencies

The Company has been informed by Bayer Diagnostics, or Bayer, that it believes the Company requires one or
more licenses to patents controlled by Bayer in order to conduct certain of the Companys current and planned operations and activities. The Company, in turn, believes that Bayer may require one or more licenses to patents controlled by the
Company. Although the Company believes it does not need a license from Bayer for its HIV products, the Company has had discussions with Bayer concerning the possibility of entering into a cross-licensing or other arrangement, and believes that if
necessary, licenses from Bayer would be available to the Company on commercial terms.

ACLARA, with which the Company merged, and certain
of its former officers and directors, referred to together as the ACLARA defendants, are named as defendants in a securities class action lawsuit filed in the United States District Court for the Southern District of New York. This action, which was
filed on November 13, 2001 and is now captioned ACLARA BioSciences, Inc. Initial Public Offering Securities Litigation, also names several of the underwriters involved in ACLARAs initial public offering, or IPO, as defendants. This class
action is brought on behalf of a purported class of purchasers of ACLARA common stock from the time of ACLARAs March 20, 2000 IPO through December 6, 2000. The central allegation in this



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action is that the underwriters in the ACLARA IPO solicited and received undisclosed commissions from, and entered into undisclosed arrangements with,
certain investors who purchased ACLARA stock in the IPO and the after-market. The complaint also alleges that the ACLARA defendants violated the federal securities laws by failing to disclose in the IPO prospectus that the underwriters had engaged
in these allegedly undisclosed arrangements. More than 300 issuers who went public between 1998 and 2000 have been named in similar lawsuits. In July 2002, an omnibus motion to dismiss all complaints against issuers and individual defendants
affiliated with issuers (including ACLARA defendants) was filed by the entire group of issuer defendants in these similar actions. On February 19, 2003, the Court in this action issued its decision on the defendants omnibus motion to
dismiss. This decision dismissed the Section 10(b) claim as to ACLARA but denied the motion to dismiss Section 11 claim as to ACLARA and virtually all of the other defendants. On June 26, 2003, the plaintiffs in the consolidated class
action lawsuits announced a proposed settlement with ACLARA and the other issuer defendants. The proposed settlement, which was approved by ACLARAs board of directors, provides that the insurers of all settling issuers will guarantee that the
plaintiffs recover $1 billion from non-settling defendants, including the investment banks who acted as underwriters in those offerings. In the event that the plaintiffs do not recover $1 billion, the insurers for the settling issuers will make up
the difference. Under the proposed settlement, the maximum amount that could be charged to ACLARAs insurance policy in the event that the plaintiffs recovered nothing from the investment banks would be approximately $3.9 million. The Company
believes that ACLARA had sufficient insurance coverage to cover the maximum amount that the Company may be responsible for under the proposed settlement. On August 31, 2005, the Court granted unconditional preliminary approval of the proposed
settlement. On April 24, 2006, the Federal District Court held a fairness hearing to determine whether the proposed settlement should be approved. The Court has not yet decided whether to approve the settlement. On December 5,
2006, the United States Court of Appeals for the 2nd Circuit issued a decision inIn re: Initial Public Offering Securities Litigation (Docket No. 05-3349-cv), reversing the Federal District Courts finding that six focus cases
involved in this litigation could be certified as class actions. It is not yet clear what impact, if any, the decision may have on the proposed settlement agreement. Plaintiffs have filed a petition for rehearing and/or for en banc review of the
Second Circuits decision, and the Federal District Court has indicated it will not make any decision regarding the proposed settlement agreement until the Second Circuit decides whether it will consider a rehearing. On January 24,
2007, the Second Circuit ordered Underwriters to file a response on certain issues to Plaintiffs request for a rehearing. Due to the inherent uncertainties of litigation and assignment of claims against the underwriters, and because the
settlement has not yet been finally approved by the Federal District Court, the ultimate outcome of the matter cannot be predicted. If a final settlement is not reached or is not approved by the Court, the Company believes that it has meritorious
defenses and intends to vigorously defend against the suit. As a result of this belief, no liability for this suit has been recorded in the accompanying financial statements. However, the Company could be forced to incur significant expenses in the
litigation, and in the event there is an adverse outcome, its business could be harmed.

License Agreements

Historically, the Company has licensed technology from Roche that the Company uses in its PhenoSense and GeneSeq tests. The Company held a non-exclusive
license for the life of the patent term of the last licensed Roche patent. The Company was notified by Roche that the license had terminated in March 2005 because the last licensed patent had expired. However, Roche advised the Company that
additional licenses may be necessary for certain other patents and has offered a license to these patents. The Company is in the process of reviewing whether additional licenses are necessary or useful for its operations. The Company believes such
licenses are available on commercially acceptable terms.



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9. CAPITAL STOCK

Authorized Common Stock

In 2004, Monogram Biosciences stockholders approved an increase to the number of authorized
shares of the Companys common stock from 100,000,000 shares to 200,000,000 shares.

Merger with ACLARA

Upon the Companys merger with ACLARA, all outstanding shares of ACLARA common stock were exchanged, or became exchangeable, for approximately
61.9 million shares of the Companys common stock. See Merger with ACLARA BioSciences, Inc. Note 6 above for further details.

Preferred Stock

Series A Redeemable Convertible Preferred Stock

In 2001, the Company issued and sold, in a private placement, an aggregate of 1,625 shares of the Companys Series A Redeemable Convertible Preferred
Stock (Series A Preferred Stock) and warrants to purchase an aggregate of 3.2 million shares of common stock, for an aggregate purchase price of $16.25 million. The Series A Preferred Stock bore an initial 6% annual dividend rate
which increased to 8% on the fourth such payment, which was made in 2003, and increased by 2 percentage points every six months thereafter up to a maximum annual rate of 14%. This dividend was paid as a stock dividend semi-annually. In June 2005,
the holders of all 249 shares of the Series A Convertible Preferred Stock then outstanding elected to convert their shares of Series A Preferred Stock into 2.3 million shares of the Companys common stock.

Warrants

In connection with the loan agreement
signed in January 1998, Monogram Biosciences issued the lender a warrant to purchase an aggregate of 34,833 shares of common stock at a price of $8.00 per share. The warrant expires in January 2008. The value of the warrant was deemed to be
insignificant and, therefore, no value was recorded. There are 34,833 warrants outstanding as of December 31, 2006.

In connection
with loan agreements signed in 2000, Monogram Biosciences issued the lender warrants to purchase an aggregate of 26,792 shares of Monogram Biosciences common stock for $4.24 per share. The warrant expires in February 2010 and was valued at
$318,000 using the Black-Scholes option valuation model. There are 26,792 warrants outstanding as of December 31, 2006.

In connection
with a service agreement signed in 2002, Monogram Biosciences issued warrants to purchase an aggregate of 100,000 shares of Monogram Biosciences common stock for $2.28 per share. The warrant expires in March 2007 and was valued at $117,000
using the Black-Scholes option valuation model. There are 100,000 warrants outstanding as of December 31, 2006.

In connection with
the November 2002 sale of Series C Preferred Stock, Monogram Biosciences issued warrants to purchase 4.8 million shares of common stock at a price of $1.11 per share. The warrant expires in November 2007 and was valued at $2.5 million using the
Black-Scholes option valuation model. The fair value of the warrants is included in additional paid-in capital. There are approximately 0.7 million warrants outstanding as of December 31, 2006.

During 2006, the Company issued 0.5 million shares of common stock upon net warrant exercises. As of December 31, 2006, outstanding warrants
are exercisable for approximately 0.8 million shares of common stock.



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Stock Option Plan

In December 2004, Monogram Biosciences stockholders approved the 2004 Equity Incentive Plan with 12.5 million shares reserved for future issuance. In addition, Monogram Biosciences has the 2000 Equity
Incentive Plan, which had been previously adopted in 1996 and was amended and renamed in February 2000. In December 2004, the Company assumed the following ACLARA plans upon the merger with ACLARA: (i) the 1995 Stock Plan, (ii) the Amended
and Restated 1997 Stock Plan, and (iii) a non-qualified option agreement. The Company will not make any future grants under the assumed ACLARA plans. Together these plans are referred to as (the Plans). The Plans provide for
the granting of options to purchase common stock and other stock awards to employees, officers, directors and consultants of Monogram Biosciences. Monogram Biosciences generally grants shares of common stock for issuance under the Plans at no less
than the fair value of the stock on the grant date; however, management is permitted to grant non-statutory stock options at a price not lower than 85% of the fair value of common stock on the date of grant. Options granted under the Plans generally
vest over four years at a rate of 25% one year from the grant date and ratably monthly thereafter.

A summary of activity under the Plans
is as follows:



|                              |  |                           |   |  |                 |   |  |                                |     
|----------------------------- |  | ------------------------- | - |  | --------------- | - |  | ------------------------------ | ----
|                              |  | Outstanding Stock Options
|                              |  | SharesAvailable           |   |  | Number ofShares |   |  | WeightedAveragePrice Per Share
|Balances at December 31, 2003 |  | 1,524,304                 |   |  | 4,664,389       |   |  | $                              | 2.45
|Additional shares authorized  |  | 12,500,000                |   |  |                |   |  |                                |    
|ACLARA options assumed        |  |                          |   |  | 7,053,500       |   |  |                                | 2.26
|Options granted               |  | (1,534,050                | ) |  | 1,534,050       |   |  |                                | 2.94
|Options exercised             |  |                          |   |  | (68,732         | ) |  |                                | 2.01
|Options expired               |  | (129,826                  | ) |  |                |   |  |                                |    
|Options forfeited             |  | 242,422                   |   |  | (242,422        | ) |  |                                | 4.20
|                              |  |                           |   |  |                 |   |  |                                |     
|Balances at December 31, 2004 |  | 12,602,850                |   |  | 12,940,785      |   |  |                                | 2.44
|Options granted               |  | (7,031,750                | ) |  | 7,031,750       |   |  |                                | 2.31
|Options exercised             |  |                          |   |  | (823,807        | ) |  |                                | 1.43
|Options forfeited             |  | 807,760                   |   |  | (807,760        | ) |  |                                | 2.82
|                              |  |                           |   |  |                 |   |  |                                |     
|Balances at December 31, 2005 |  | 6,378,860                 |   |  | 18,340,968      |   |  |                                | 2.42
|Options granted               |  | (4,095,990                | ) |  | 4,095,990       |   |  |                                | 1.68
|Options exercised             |  |                          |   |  | (2,444,776      | ) |  |                                | 1.33
|Options forfeited             |  | 781,122                   |   |  | (781,122        | ) |  |                                | 2.79
|                              |  |                           |   |  |                 |   |  |                                |     
|Balances at December 31, 2006 |  | 3,063,992                 |   |  | 19,211,060      |   |  |                                | 2.39
|                              |  |                           |   |  |                 |   |  |                                |     



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The following table summarizes information about the stock options outstanding under the Plans at
December 31, 2006:



|                        |  |                     |  |                                                     |  |                                |       |                   |            |                                |   |      
|----------------------- |  | ------------------- |  | --------------------------------------------------- |  | ------------------------------ | ----- | ----------------- | ---------- | ------------------------------ | - | -----
|                        |  | Options Outstanding |  | Options Exercisable                                
|Range of Exercise Price |  | NumberOutstanding   |  | Weighted AverageRemainingContractual Life(in years) |  | Weighted AverageExercise Price |       | NumberExercisable |            | Weighted AverageExercise Price
|$0.24  $  1.16         |  | 140,188             |  | 4.18                                                |  | $                              | 0.83  |                   | 140,062    |                                | $ | 0.83 
|$1.22  $  1.27         |  | 1,504,227           |  | 6.23                                                |  |                                | 1.25  |                   | 1,413,986  |                                |   | 1.25 
|$1.29  $  1.51         |  | 898,239             |  | 6.52                                                |  |                                | 1.47  |                   | 732,673    |                                |   | 1.47 
|$1.53  $  2.27         |  | 4,709,341           |  | 7.18                                                |  |                                | 1.72  |                   | 864,019    |                                |   | 1.94 
|$2.28                   |  | 5,709,942           |  | 6.16                                                |  |                                | 2.28  |                   | 2,506,807  |                                |   | 2.28 
|$2.30  $  2.40         |  | 461,704             |  | 6.40                                                |  |                                | 2.37  |                   | 381,910    |                                |   | 2.38 
|$2.41  $  2.57         |  | 1,178,157           |  | 5.82                                                |  |                                | 2.52  |                   | 907,825    |                                |   | 2.54 
|$2.58  $  2.98         |  | 1,388,943           |  | 3.14                                                |  |                                | 2.69  |                   | 1,197,141  |                                |   | 2.70 
|$3.00  $  3.10         |  | 1,179,862           |  | 7.19                                                |  |                                | 3.00  |                   | 837,417    |                                |   | 3.00 
|$3.13  $  3.14         |  | 784,000             |  | 2.69                                                |  |                                | 3.14  |                   | 784,000    |                                |   | 3.14 
|$3.18  $  5.40         |  | 573,092             |  | 3.94                                                |  |                                | 3.80  |                   | 565,301    |                                |   | 3.81 
|$5.74  $  8.00         |  | 490,515             |  | 4.01                                                |  |                                | 6.34  |                   | 490,515    |                                |   | 6.34 
|$8.56  $22.13          |  | 192,850             |  | 3.82                                                |  |                                | 12.05 |                   | 192,850    |                                |   | 12.05
|                        |  |                     |  |                                                     |  |                                |       |                   |            |                                |   |      
|                        |  | 19,211,060          |  |                                                     |  |                                |       |                   | 11,014,506 |                                |   |      
|                        |  |                     |  |                                                     |  |                                |       |                   |            |                                |   |      

The weighted-average remaining contractual term of the exercisable stock options at
December 31, 2006 is 5.4 years. As of December 31, 2006, the aggregate intrinsic value of outstanding stock options was $1.7 million and the aggregate intrinsic value of exercisable stock options was $1.1 million.

The intrinsic value of options exercised was $1.3 million and $0.9 million in 2006 and 2005, respectively. The Company received $3.3 million and $1.2
million from the exercise of stock options in 2006 and 2005, respectively. The Company issues new shares upon the exercise of stock options. There was no tax benefit realized upon exercise of stock options in 2006 and 2005.

Employee Stock Purchase Plan

In February 2000, the
board of directors adopted the 2000 Employee Stock Purchase Plan (the Stock Plan). The Stock Plan permits eligible employees to acquire shares of Monogram Biosciences common stock through payroll deductions of up to 15% of their
eligible earnings. All full-time employees of Monogram Biosciences, except 5% stockholders, are eligible to participate in the Stock Plan. The purchase price of the shares is the lesser of 85% of the fair value of the shares at the offering date or
purchase date, as defined by the Stock Plan. In December 2004, the Companys stockholders approved the reservation of an additional 1.0 million shares to be reserved for issuance under the Stock Plan and an annual automatic share increase
provision to the Stock Plan. The amount of the automatic increase may be reduced to a lesser amount, as determined by the board of directors. During 2006, the Company added 1.0 million shares to the Stock Plan under this provision. Of the
3.0 million shares of common stock reserved for issuance under the Stock Plan, 2.0 million shares were issued as of December 31, 2006.



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401(k) Plan

Monogram Biosciences 401(k) Plan covers substantially all employees. Employees may contribute up to 15% of their eligible compensation, subject to certain Internal Revenue Service restrictions. Monogram
Biosciences matches employee contributions in the form of Monogram Biosciences common shares. In 2000, the 401(k) Plan was amended to increase the matching percentage to 25% of the employee contribution. The match is effective December 31 of
each year and is fully vested when made. Monogram Biosciences recorded 401(k) matching expense of $0.5 million, $0.4 million and $0.2 million in 2006, 2005 and 2004, respectively. As of December 31, 2006, Monogram Biosciences had issued
approximately 0.6 million shares under the matching provisions of the 401(k) Plan and 0.3 million shares were due by the Company to the 401(k) plan in respect of the 2006 matching contributions.

Reserved Shares

At December 31, 2006, Monogram
Biosciences had reserved shares of common stock for future issuance as follows:



|                                                    |  |               
|--------------------------------------------------- |  | --------------
|                                                    |  | SharesReserved
|                                                    |  | (In thousands)
|Convertible promissory note (as if converted basis) |  | 11,026        
|Stock options                                       |  | 19,211        
|Warrants                                            |  | 819           
|Employee Stock Purchase Plan                        |  | 1,911         
|                                                    |  |               
|                                                    |  | 21,941        
|                                                    |  |               

10. INCOME TAXES

At December 31, 2006, Monogram Biosciences had federal and state net operating loss carryforwards of approximately $280.8 million and $112.0 million, respectively. At December 31, 2006, Monogram Biosciences
also had federal and state research and development credits of approximately $5.8 million and $5.8 million, respectively. The federal net operating loss and credit carryforwards will expire at various dates between the years 2010 and 2026, if not
utilized. The federal and state operating loss carryforwards include deductions for stock options. The state of California net operating loss carryforwards will expire at various dates between the years 2012 and 2016, if not utilized. The California
research and development credits can be carried forward indefinitely.

Utilization of the federal and state net operating loss and credit
carryforwards may be subject to a substantial annual limitation due to the change in ownership provisions of the Internal Revenue Code of 1986. The annual limitation may result in the expiration of net operating losses and credits before
utilization. When utilized to reduce income tax payables, the portion related to stock options deductions will be accounted for as a credit to shareholders equity.



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Deferred income taxes reflect the net tax effects of temporary differences between the carrying
amounts of assets for financial reporting purposes and the amount used for income tax purposes. Significant components of Monogram Biosciences deferred tax assets for federal and state income taxes are as follows:



|                                                       |  |                |          |   |      |   |          |  
|------------------------------------------------------ |  | -------------- | -------- | - | ---- | - | -------- | -
|                                                       |  | December 31,   |         
|                                                       |  | 2006           |          |   | 2005 |  
|                                                       |  | (In thousands) |         
|Deferred tax assets:                                   |  |                |          |   |      |   |          |  
|Net operating loss carryforwards                       |  | $              | 47,500   |   |      | $ | 42,100   |  
|Research and other credits                             |  |                | 4,200    |   |      |   | 3,000    |  
|Capitalized research and development                   |  |                | 2,500    |   |      |   | 2,200    |  
|Other                                                  |  |                | 3,800    |   |      |   | 4,500    |  
|Deferred tax assets as a result of merger with ACLARA: |  |                |          |   |      |   |          |  
|Acquired net operating loss carryforwards              |  |                | 54,500   |   |      |   | 54,700   |  
|Acquired research and other credits                    |  |                | 5,800    |   |      |   | 5,800    |  
|Capitalized research and development                   |  |                | 1,900    |   |      |   | 2,300    |  
|Other                                                  |  |                | 1,800    |   |      |   | 2,400    |  
|                                                       |  |                |          |   |      |   |          |  
|Total deferred tax assets                              |  |                | 122,000  |   |      |   | 117,000  |  
|Valuation allowance                                    |  |                | (122,000 | ) |      |   | (117,000 | )
|                                                       |  |                |          |   |      |   |          |  
|Net deferred taxes                                     |  | $              |         |   |      | $ |         |  
|                                                       |  |                |          |   |      |   |          |  

Due to Monogram Biosciences lack of earnings history, the net deferred tax assets have been
fully offset by a valuation allowance. The valuation allowance increased by $5.0 million, $3.9 million and $1.5 million in 2006, 2005 and 2004.

A reconciliation of the statutory tax rates and the effective tax rates for the periods ended:



|                                    |  |              |    |  |        |    |  |        |   
|----------------------------------- |  | ------------ | -- |  | ------ | -- |  | ------ | --
|                                    |  | December 31, |   
|                                    |  | 2006         |    |  | 2005   |    |  | 2004   |   
|Tax at federal statutory rate       |  | (34.00       | )% |  | (34.00 | )% |  | (34.00 | )%
|State, net of federal benefit       |  | (5.83        | )  |  | (5.83  | )  |  | (5.83  | ) 
|Research & development credits      |  | (2.47        | )  |  | (2.76  | )  |  | (0.23  | ) 
|Valuation allowance                 |  | 13.09        |    |  | 10.37  |    |  | 1.81   |   
|Stock-based compensation            |  | 6.24         |    |  | (3.36  | )  |  | 1.43   |   
|CVR revaluation                     |  | 17.75        |    |  | 29.05  |    |  | (11.91 | ) 
|Others                              |  | 5.22         |    |  | 6.53   |    |  | 0.35   |   
|In-process research and development |  |             |    |  |       |    |  | 42.00  |   
|Purchase accounting adjustments     |  |             |    |  |       |    |  | 6.38   |   
|                                    |  |              |    |  |        |    |  |        |   
|Provision for taxes                 |  |             | %  |  |       | %  |  |       | % 
|                                    |  |              |    |  |        |    |  |        |   

11. RESTRUCTURING

In connection with the Companys merger with ACLARA, the Company has taken actions to integrate and restructure the former ACLARA operations. The Company relocated the ACLARA personnel and operations from the
facility in Mountain View, California to its South San Francisco, California facilities in the second quarter of 2005. A restructuring accrual was established for the costs of vacating and subleasing the Mountain View facility including an estimate
of the excess of our lease costs over our anticipated sublease income and for



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the anticipated severance costs for ACLARA employees whose employment was terminated as a result of the merger. The accrual established at the closing of the
merger related to the Mountain View facility was $3.0 million. In addition, a restructuring accrual of $1.1 million was established for the anticipated severance costs for ACLARA employees whose employment was terminated as a result of the merger.
Additional restructuring accruals, due to delays in vacating and subleasing the Mountain View facility, were recorded in the amounts of $1.6 million and $0.3 million in 2005 and 2006, respectively. In February 2007, the Company executed a
termination agreement with respect to the lease in exchange for a reduced but fixed payment commitment over the remainder of the previous lease term. The initial charge of $1.6 million to the estimates of completing the approved restructuring plans
was recorded in goodwill and subsequent adjustments to these estimates have been recorded in the Companys results of operations.

The
following table sets forth an analysis of the components of the restructuring charges (in thousands):



|                                                                             |  |                          |        |   |           |   |        |       |  |   |        |  
|---------------------------------------------------------------------------- |  | ------------------------ | ------ | - | --------- | - | ------ | ----- |  | - | ------ | -
|                                                                             |  | Abandonmentof Facilities |        |   | Severance |   |        | Total | 
|                                                                             |  | (In thousands)           |       
|Liabilities assumed in merger with ACLARA                                    |  | $                        | 3,000  |   |           | $ | 1,054  |       |  | $ | 4,054  |  
|Amounts paid in cash                                                         |  |                          | (24    | ) |           |   |       |       |  |   | (24    | )
|                                                                             |  |                          |        |   |           |   |        |       |  |   |        |  
|Balance at December 31, 2004                                                 |  |                          | 2,976  |   |           |   | 1,054  |       |  |   | 4,030  |  
|Amounts paid in cash                                                         |  |                          | (1,288 | ) |           |   | (1,054 | )     |  |   | (2,342 | )
|Change in estimate for restructuring costs related to Mountain View facility |  |                          | 1,645  |   |           |   |       |       |  |   | 1,645  |  
|                                                                             |  |                          |        |   |           |   |        |       |  |   |        |  
|Balance at December 31, 2005                                                 |  |                          | 3,333  |   |           |   |       |       |  |   | 3,333  |  
|Amounts paid in cash                                                         |  |                          | (1,656 | ) |           |   |       |       |  |   | (1,656 | )
|Change in estimate for restructuring costs related to Mountain View facility |  |                          | 319    |   |           |   |       |       |  |   | 319    |  
|                                                                             |  |                          |        |   |           |   |        |       |  |   |        |  
|Balance at December 31, 2006                                                 |  | $                        | 1,996  |   |           | $ |       |       |  | $ | 1,996  |  
|                                                                             |  |                          |        |   |           |   |        |       |  |   |        |  
|Current portion                                                              |  | $                        | 1,128  |   |           | $ |       |       |  | $ | 1,128  |  
|                                                                             |  |                          |        |   |           |   |        |       |  |   |        |  
|Non-current portion                                                          |  | $                        | 868    |   |           | $ |       |       |  | $ | 868    |  
|                                                                             |  |                          |        |   |           |   |        |       |  |   |        |  

Other Severance Costs

On September 28, 2005, the Company entered into a separation and release agreement with a former executive and recorded a severance charge of $0.4 million in the statement of operations for the year ended
December 31, 2005 all of which has been paid as of December 31, 2006.

12. COLLABORATION AND NOTE PURCHASE AGREEMENT

On May 5, 2006, the Company entered into a Collaboration Agreement with Pfizer, Inc. (Pfizer) regarding the Companys Trofile
Co-Receptor Tropism Assay (the Collaboration Agreement). The Collaboration Agreement has an initial term that expires on December 31, 2009, and is renewable by Pfizer for five successive one-year terms.

Under the agreement, the Company and Pfizer will collaborate to make the Companys Trofile Co-Receptor Tropism Assay available globally. The Company
will be responsible for making the assay available in the U.S.



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



and performing the assay in accordance with agreed upon performance standards. The Company will also be obligated to undertake certain efforts to plan for,
establish and maintain an infrastructure to support the commercial availability of the assay outside the U.S. in countries designated by Pfizer, and it will be obligated to perform the assay with respect to patient blood samples originating outside
of the U.S. in accordance with agreed upon performance standards. Pfizer will be responsible for sales, marketing and regulatory matters related to the assay outside of the U.S. Pfizer will reimburse the Company for costs incurred in establishing
and maintaining the necessary logistics infrastructure to make the assay available outside of the U.S., and Pfizer will pay the Company for each assay that the Company performs with respect to patient blood samples originating outside of the U.S.

Subject to certain limitations, Pfizer will be entitled to establish its own facility to perform the assay in support of its human
clinical trials, and to perform the assay in respect of patient blood samples following certain uncured material breaches of the Collaboration Agreement (including the performance standards) by the Company. For such purposes, the Company has granted
Pfizer a license to use certain intellectual property rights and proprietary materials related to the Companys Trofile Co-Receptor Tropism Assay. The Company will be obligated in such a case to assist Pfizer in establishing and operating such
facility, for which Pfizer will reimburse for costs the Company incurs in providing such assistance. To secure the Companys obligations under the license described above, the Company has granted Pfizer a security interest in certain of its
intellectual property rights and proprietary materials related to the Companys Trofile Co-Receptor Tropism Assay. Pfizer and the Company have also extended the co-receptor portion of their existing services agreement for support of potential
additional Pfizer clinical trials through December 31, 2009.

In accordance with Emerging Issues Task Force Issue No. 00-21,
Revenue Arrangements with Multiple Deliverables, (EITF 00-21) revenue arrangements entered into after June 15, 2003, that include multiple element arrangements are analyzed to determine whether the deliverables are
divided into separate units of accounting or as a single unit of accounting. Revenues are allocated to a delivered product or service when all of the following criteria are met: (1) the delivered item has value to the customer on a standalone
basis; (2) there is objective and reliable evidence of the fair value of the undelivered item; and (3) if the arrangement includes a general right of return relative to the delivered item, delivery or performance of the undelivered item is
considered probable and substantially in our control. If all of the three required criteria under EITF 00-21 are met, then the deliverables would be accounted for separately, completed as performed. Otherwise, the arrangement would be accounted for
as a single unit of accounting and the payments for performance obligations are recognized as revenue over the estimated period of when the performance obligations are performed. If the Company cannot reasonably estimate when its performance
obligation either ceases or becomes inconsequential, then revenue is deferred until the Company can reasonably estimate when the performance obligation ceases or becomes inconsequential.

The Pfizer collaboration is a multiple element arrangement, including supply of the Trofile Assay in additional clinical studies (including expanded
access programs in both the U.S. and outside the U.S.), supply of the Trofile Assay for clinical use outside of the U.S., reimbursement of costs for the establishment and operation of supply infrastructure outside of the U.S. and potential
assistance to Pfizer in the establishment and operation of a second facility for processing of tropism assays. Under the guidelines of EITF 00-21, the Company has determined that the collaboration with Pfizer should be accounted for as a single unit
of accounting due to the absence of established fair values of certain undelivered elements. Accordingly, the Company has deferred revenue under this collaboration until the earlier of establishment of fair values or completion of the deliverables.
Additionally, related direct costs that are contractually reimbursable on a non-refundable basis under this collaboration have been deferred.



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



On May 5, 2006 the Company also entered into a Note Purchase Agreement with Pfizer, which was
amended in January 2007, pursuant to which it sold to Pfizer a 3% Senior Secured Convertible Note in the principal amount of $25 million (the Note). For further discussion, see Subsequent Events Note 14 below. The closing of
the sale and issuance of the Note occurred on May 19, 2006. The Note will mature four years from its date of issuance. The Company will pay interest quarterly in arrears on March 31, June 30, September 30 and
December 31 of each year, commencing on June 30, 2006. Subject to certain limitations, the Company will be entitled to make such interest payments using shares of its common stock instead of cash.

The Note is convertible into shares of the Companys common stock at the election of its holder at a per share conversion price of $2.7048.
Following the effectiveness of the registration statement covering the estimated number of common shares underlying the Note, which occurred June 23, 2006, the Note will automatically convert into shares of the Companys common stock
should the closing price of the Companys common stock be greater than 150% of the conversion price, or $4.06 per share, for twenty out of the thirty consecutive trading days. The conversion price will adjust automatically upon certain changes
to the Companys capitalization. The Company will be required, under the terms of the Note, to repurchase the outstanding amount of the Note at the election of the holder upon certain change of control events described in the Note, or if its
common stock is no longer listed or quoted on the Nasdaq National Market or an established automated over-the-counter trading market (including, if applicable, the OTC Bulletin Board). The Note is secured by a first priority security interest in
favor of Pfizer in certain of the Companys assets related to its HIV testing business.

Under the terms of the Note, the Company is
prohibited from incurring certain types of indebtedness, from permitting certain liens on its assets, from entering into transactions with affiliates and from entering into certain capital transactions such as dividends, stock repurchases, capital
distributions or other similar transactions. It is also subject to certain other covenants as set forth in the Note, including limitations on its ability to enter into new lines of business after issuance of the Note. An event of default under the
Note will occur if the Company: is delinquent in making payments of principal or interest; fails, following notice, to cure a breach of a covenant under the Note, the related security agreement or the Note Purchase Agreement; a representation or
warranty under the Note, the related security agreement or the Note Purchase Agreement is materially inaccurate; an acceleration event occurs under certain types of its other secured indebtedness outstanding from time to time; certain bankruptcy
proceedings are commenced or orders granted or an event of default occurs or is continuing under the 0% convertible senior unsecured notes issued in January 2007. If an event of default occurs, the indebtedness under the Note could be accelerated,
such that it becomes immediately due and payable. The Company is in compliance with all covenants under the Note.

13. CREDIT AND SECURITY AGREEMENT

On September 29, 2006, the Company entered into a Credit and Security Agreement with Merrill Lynch Capital, a division of Merrill
Lynch Business Financial Services Inc. (Merrill). The Credit and Security Agreement (the Agreement) provides the Company with a revolving credit line, with borrowings against eligible accounts receivable up to a maximum of $10
million. Merrill has been granted a security interest over certain of the Companys assets, including its accounts receivable, intellectual property used or held for use in connection with its oncology testing business and inventory. The
Agreement has a term expiring in March 2010. As of December 31, 2006, approximately $5.6 million was outstanding under the revolving credit line.

Amounts borrowed under the Agreement will bear interest at a rate per annum equal to a published LIBOR rate plus 4.75%. As of December 31, 2006, the 1-month LIBOR rate was 5.35%. Amounts borrowed under the
revolving credit line are repaid as the Company receives payment on its outstanding accounts receivable. The



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



Agreement also provides for the payment by the Company of an unused line fee, a collateral fee, a commitment fee and, in certain circumstances, a deferred
commitment fee.

Under the terms of the Agreement, the Company is prohibited from incurring certain types of indebtedness and certain liens
on its assets. It is also subject to certain other affirmative and negative covenants as set forth in the Agreement. An event of default under the note will occur if, among other things, the Company: is delinquent in making payments of principal,
interest or fees on the revolving credit line; fails, following notice, to cure a breach of a covenant under the Agreement; a representation or warranty under the Agreement is materially inaccurate; certain liquidation or bankruptcy proceedings are
commenced or certain orders are granted against Monogram; the security interests granted by the Company in favor or Merrill, fail, in certain circumstances, to constitute valid security interests; or an acceleration event occurs under certain types
of the Companys other secured indebtedness outstanding from time to time. If an event of default occurs, the indebtedness to Merrill under the Agreement could be accelerated, such that it becomes immediately due and payable. The Company is in
compliance with all covenants under the Agreement.

14. SUBSEQUENT EVENTS

0% Convertible Senior Unsecured Notes

In January 2007, the Company entered into a Securities
Purchase Agreement to sell $30 million principal amount of a 0% Convertible Senior Unsecured Note (the 0% Notes) to a single qualified institutional buyer. The aggregate purchase price for the 0% Notes was approximately $22.5 million.
Although due in 2026, the 0% Notes may be called by the investor at December 31, 2011, December 31, 2016 or December 31, 2021, at a price equal to 100% of the accreted value.

The 0% Notes will not bear interest and will be convertible, at the option of the holder of such 0% Notes, into shares of the Companys common stock
at an initial conversion price of $2.52 per share, which is equivalent to an initial conversion rate of approximately 396.8254 shares per $1,000 principal amount of 0% Notes. The conversion price will adjust automatically upon certain changes to the
Companys capitalization.

Pursuant to a Registration Rights Agreement dated as of January 11, 2007 by and between the Company
and the qualified institutional buyer, the Company intends to file a shelf registration statement with respect to the resale of the 0% Notes and the common stock issuable upon conversion thereof. The Company intends to file this registration
statement within sixty days of the closing of the transaction and to cause such registration statement to become effective within 120 days of the closing of the transaction unless the SEC reviews the registration statement and provides comments
thereon or requires the Company to make modifications thereto, in which case the Company must cause such registration to become effective within 180 days of the closing. In the event the Company fails to comply with its obligations under the
Registration Rights Agreement, it will be obligated to make additional payments to the holders of the 0% Notes.

After this registration
statement is effective, the Company will have the option to cause all or any portion of the 0% Notes to automatically convert at such time as the closing price of the Companys common stock is greater than $3.15 for twenty out of thirty
consecutive trading days and certain other limitations. Upon any such automatic conversion, the Company initially will pay the holders a premium make-whole amount equal to $84.7526 per $1,000 principal amount of 0% Notes so converted, such premium
make-whole being reduced over the initial 3 year period following the closing. The premium make-whole amount may be paid in shares of common stock upon any such automatic conversion, provided that certain additional conditions are satisfied.



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



The 0% Notes are subordinated to all of the Companys present senior debt, including the $25
million 3% Senior Secured Convertible Note due May 19, 2010 issued to Pfizer in May 2006, as amended as described below, and the Companys line of credit with Merrill Lynch.

Beginning on December 31, 2009, the Company may redeem the 0% Notes in whole or in part at any time at a redemption price equal to the accreted
value of the principal amount of the 0% Notes to be redeemed, plus liquidated damages, if any, and certain other amounts, provided that certain conditions are required to be satisfied and the market price of the Companys common stock exceeds
the conversion price of the 0% Notes leading up to and at the time of redemption.

The Company will be required, under the terms of the 0%
Notes, to repurchase the outstanding accreted value of the 0% Notes at the election of the holder upon certain change of control events described in the 0% Notes, or if the Companys common stock is no longer listed on a United States national
securities exchange, quoted on The NASDAQ Capital Market, or approved for trading and/or eligible for quotation on an established automated over-the-counter trading market in the United States, including the OTC Bulletin Board but excluding the
pink sheets or any similar quotation system. In addition, under such circumstances the Company also would be obligated to pay the premium make-whole amount described above and certain other amounts.

An event of default under the 0% Notes will occur if the Company: is delinquent in making certain payments due under the 0% Notes; fails to deliver
shares upon conversion of the 0% Notes; fails to deliver certain required notices under the 0% Notes; fails, following notice, to cure a breach of a covenant under the 0% Notes, the Securities Purchase Agreement, the Registration Rights Agreement,
the Subordination Agreement with Pfizer Inc. described below, or the Indenture described below (together, the Transaction Documents); certain events of default occur with respect to other indebtedness; certain bankruptcy proceedings are
commenced or orders granted; a representation or warranty made under the Transaction Documents is materially inaccurate and continues uncured following notice; the Company fails to file certain periodic reports with the Securities and Exchange
Commission (subject to certain grace periods); or the Company incurs certain types of indebtedness prohibited under the terms of the 0% Notes. If an event of default occurs, the indebtedness under the 0% Notes could be accelerated, such that it
becomes immediately due and payable.

In connection with the sale of the 0% Notes, the Company, Pfizer and U.S. Bank, National Association,
as trustee, entered into a subordination agreement. The subordination agreement sets forth the terms under which the 0% Notes are subordinated to the 3.0% Senior Secured Convertible Note Due May 19, 2010, issued to Pfizer. As a condition to the
entry into the subordination agreement, the Company and Pfizer amended the Note Purchase Agreement, dated May 5, 2006, between Pfizer and the Company, and amended and restated the 3.0% Senior Secured Convertible Note Due May 19, 2010, to
conform to certain terms of the subordination agreement. As amended, the Pfizer Note provides that the Company will be in default thereof if (i) an event of default occurs and is continuing under the 0% Notes and (ii) the trustee or any
holders of the 0% Notes give notice to the Company of its or their intent to either accelerate the 0% Notes or exercise any other remedies thereunder (subject to certain limited exceptions).

The Company expects that, as a result of certain aspects of the 0% Notes, it will be required to separately value and account for certain derivative
instruments that are embedded in the 0% Notes, as assets or liabilities with adjustments to fair value reflected in the statement of operations. While such adjustments have not, through December 31, 2006, been required for the Pfizer Note, as a
result of the issuance of the 0% Notes in January 2007, the Company expects that it will be required to similarly account for derivative instruments that are embedded in the Pfizer Note commencing in the first quarter of 2007.



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MONOGRAM BIOSCIENCES, INC.

NOTES TO FINANCIAL STATEMENTS(Continued)

December 31, 2006



Lease Termination

On February 7, 2007, the Company entered into a Lease Termination Agreement to terminate the lease on the former ACLARA facility in Mountain View, California. Under the terms of the Lease, the scheduled
expiration date was July 15, 2009. Following the December 2004 merger between the Company and ACLARA, the Company consolidated its operations and determined that it did not require the facility and established a restructuring accrual to provide
for the estimated costs to vacate and sublease the facility.

The termination of the Lease was subject to a specified third party executing
a new lease with the landlord on terms and conditions satisfactory to the landlord and the landlord has notified the Company that this has occurred. Additionally, the Company has an obligation to pay the Landlord specified amounts over the remainder
of the former lease term, or through June 2009. Upon execution of the Lease Termination Agreement, the Company paid the outstanding principal and interest owed to the landlord under a promissory note, in the aggregate amount of approximately
$235,000. Certain late charges may apply for late payments on any of the above-described monetary obligations.

As a result of the Lease
Termination Agreement, the Company reduced the previously established restructuring accrual by $0.2 million in the quarter ended December 31, 2006, with the adjustment reflected in statements of operations.

15. QUARTERLY RESULTS OF OPERATIONS (UNAUDITED)



|                                                 |  |                                          |        |   |          |   |         |               |  |   |              |   |  |   |         |  
|------------------------------------------------ |  | ---------------------------------------- | ------ | - | -------- | - | ------- | ------------- |  | - | ------------ | - |  | - | ------- | -
|                                                 |  | Quarter Ended                            |       
|                                                 |  | March 31,                                |        |   | June 30, |   |         | September 30, |  |   | December 31, |  
|                                                 |  | (In thousands, except per share amounts) |       
|2006                                             |  |                                          |        |   |          |   |         |               |  |   |              |   |  |   |         |  
|Product revenue                                  |  | $                                        | 12,246 |   |          | $ | 12,757  |               |  | $ | 10,415       |   |  | $ | 9,732   |  
|Contract revenue                                 |  |                                          | 1,003  |   |          |   | 620     |               |  |   | 687          |   |  |   | 498     |  
|                                                 |  |                                          |        |   |          |   |         |               |  |   |              |   |  |   |         |  
|Total revenue                                    |  |                                          | 13,249 |   |          |   | 13,377  |               |  |   | 11,102       |   |  |   | 10,230  |  
|Gross profit                                     |  |                                          | 7,568  |   |          |   | 7,713   |               |  |   | 5,140        |   |  |   | 4,834   |  
|Contingent value rights revaluation              |  |                                          | 14     |   |          |   | (16,464 | )             |  |   |             |   |  |   |        |  
|Net loss                                         |  |                                          | (3,353 | ) |          |   | (21,764 | )             |  |   | (6,604       | ) |  |   | (6,982  | )
|Basic and diluted income (loss) per common share |  | $                                        | (0.03  | ) |          | $ | (0.17   | )             |  | $ | (0.05        | ) |  | $ | (0.05   | )
|                                                 |  |                                          |        |  
|2005                                             |  |                                          |        |   |          |   |         |               |  |   |              |   |  |   |         |  
|Product revenue                                  |  | $                                        | 8,853  |   |          | $ | 11,005  |               |  | $ | 12,136       |   |  | $ | 11,474  |  
|Contract revenue                                 |  |                                          | 1,141  |   |          |   | 1,409   |               |  |   | 1,002        |   |  |   | 1,232   |  
|                                                 |  |                                          |        |   |          |   |         |               |  |   |              |   |  |   |         |  
|Total revenue                                    |  |                                          | 9,994  |   |          |   | 12,414  |               |  |   | 13,138       |   |  |   | 12,706  |  
|Gross profit                                     |  |                                          | 5,655  |   |          |   | 7,439   |               |  |   | 7,732        |   |  |   | 7,425   |  
|Contingent value rights revaluation              |  |                                          | 5,306  |   |          |   | (4,062  | )             |  |   | 7,249        |   |  |   | 17,803  |  
|Net income (loss)                                |  |                                          | (7,360 | ) |          |   | 688     |               |  |   | (9,611       | ) |  |   | (21,303 | )
|Basic and diluted income (loss) per common share |  | $                                        | (0.06  | ) |          | $ |        |               |  | $ | (0.08        | ) |  | $ | (0.17   | )



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Item 9.Changes in and Disagreements with Accountants on Accounting and Financial Disclosure

None.

Item 9A.Controls and Procedures

Evaluation of Disclosure Controls and Procedures

We maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in the reports that are filed under
the Securities Exchange Act of 1934 is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the Securities and Exchange Commission, and that such information is accumulated and communicated to the
Companys management, including the Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure.

Our Chief Executive Officer and Chief Financial Officer, with the assistance of other members of our management, have evaluated our disclosure controls and procedures as defined in Rules 13a-15(e) and 15d-15(e) under
the Securities Exchange Act of 1934, as of the end of the period covered by this report, and have concluded based on that evaluation that those disclosure controls and procedures are effective.

Our management, including our Chief Executive Officer and Principal Financial Officer, does not expect that our disclosure controls and procedures or our
internal controls will prevent all errors and all fraud. A control system, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of the control system are met. Further, the design of a
control system must reflect the fact that there are resource constraints, and the benefits of controls must be considered relative to their costs. Because of the inherent limitations in all control systems, no evaluation of controls can provide
absolute assurance that all control issues and instances of fraud, if any, within Monogram Biosciences have been detected.

Changes in Internal Control
over Financial Reporting

There has been no change in the Companys internal control over financial reporting during the
Companys most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the Companys internal control over financial reporting.

Managements Report on Internal Control over Financial Reporting

Our management is responsible
for establishing and maintaining adequate internal control over financial reporting, as such term is defined in Exchange Act Rules 13a-15(f) and 15d-15(f). Under the supervision and with the participation of our management, including our Chief
Executive Officer and Chief Financial Officer, we conducted an evaluation of the effectiveness of our internal control over financial reporting as of December 31, 2006 based on the framework in Internal ControlIntegrated Framework issued
by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). Based on that evaluation, our management concluded that our internal control over financial reporting was effective as of December 31, 2006.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any
evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

Managements assessment of the effectiveness of our internal control over financial reporting as of December 31, 2006 has been audited by
PricewaterhouseCoopers LLP, an independent registered public accounting firm, as stated in their report which is included under Item 8.

Item 9B.Other Information

None.



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PART III

Item 10.Directors and Executive Officers of the Registrant

We have adopted a Code of
Business Conduct and Ethics Policy that applies to our directors and employees (including our principal executive officer, principal financial officer, principal accounting officer and controller), and have posted the text of the policy on our
website (www.monogrambio.com) in connection with Investor materials. In addition, we intend to promptly disclose (i) the nature of any amendment to the policy that applies to our principal executive officer, principal financial
officer, principal accounting officer or controller, or persons performing similar functions and (ii) the nature of any waiver, including an implicit waiver, from a provision of the policy that is granted to one of these specified individuals,
the name of such person who is granted the waiver and the date of the waiver on our website in the future.

The other information required
by this item is incorporated by reference to the proxy statement to be filed with the SEC pursuant to Regulation 14A in connection with our 2007 annual meeting.

Item 11.Executive Compensation

The information required by this item is incorporated by
reference to the information under the caption Executive Compensation to be contained in our 2007 proxy statement.

Item 12.Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

The information required by this item is incorporated by reference to the information under the caption Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters to be
contained in our 2007 proxy statement.

Item 13.Certain Relationships and Related Transactions

The information required by this
item is incorporated by reference to the information under the caption Certain Transactions to be contained in our 2007 proxy statement.

Item 14.Principal Accounting Fees and Services

The information required by this item is
incorporated by reference to the information under the captions Independent Auditors Fees and Pre-Approval Policies and Procedures to be contained in our 2007 proxy statement.

Consistent with Section 10A(i)(2) of the Securities Exchange Act of 1934, as added by Section 202 of the Sarbanes-Oxley Act of 2002, we are
responsible for listing the non-audit services approved by our Audit Committee to be performed by PricewaterhouseCoopers LLP, our independent registered public accounting firm. Non-audit services are defined as services other than those provided in
connection with an audit or a review of our financial statements. The Audit Committee has approved our recurring engagements of PricewaterhouseCoopers LLP for the following non-audit services: (1) preparation of tax returns, and tax advice in
preparing for and in connection with such filings; (2) all work required to be performed by PricewaterhouseCoopers LLP in connection with preparing and providing consents required to be given in connection with our filings with the Securities
and Exchange Commission, and (3) advice in preparing for the internal control documentation requirements of Section 404 of the Sarbanes-Oxley Act of 2002.



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PART IV

Item 15.Exhibits and Financial Statement Schedules

(a)(1) Index to Financial Statements

Reference is made to the Index to Financial Statements under Item 8 in Part II hereof, where these documents are listed.

(a)(2) Financial Statement ScheduleThe following schedule is filed as part of this Form 10-K:

Schedule II  Valuation and Qualifying Accounts for the years ended December 31, 2006, 2005 and 2004.

All other schedules have been omitted because they are not applicable or required, or the information required to be set forth therein is included in the
Financial Statements or notes thereto included in Item 8 (Financial Statements and Supplementary Data).

(a)(3) Index to
ExhibitsSee (c) below.

(c) Exhibits



|                |  |               |  |                                                                                                                                                                                                                         
|--------------- |  | ------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitFootnote |  | ExhibitNumber |  |                                                                                                                                                                                                                         
|(12)            |  | 2.1           |  | Agreement and Plan of Merger and Reorganization, dated as of May 28, 2004, by and among ViroLogic, Inc., Apollo Acquisition Sub, Inc., Apollo Merger Subsidiary, LLC and ACLARA BioSciences,
Inc.                       
|                |  |              
|(13)            |  | 2.2           |  | Amendment No. 1 to Agreement and Plan of Merger and Reorganization, dated as of October 18, 2004, by and among ViroLogic, Inc., Apollo Acquisition Sub, Inc., Apollo Merger Subsidiary, LLC and
ACLARA BioSciences, Inc.
|                |  |              
|(9)             |  | 3.1           |  | Amended and Restated Certificate of Incorporation, filed July 17, 2000.                                                                                                                                                 
|                |  |              
|(9)             |  | 3.1.1         |  | Certificate of Amendment to Amended and Restated Certificate of Incorporation, filed February 4, 2003.                                                                                                                  
|                |  |              
|(16)            |  | 3.1.2         |  | Certificate of Amendment to Amended and Restated Certificate of Incorporation, filed December 10, 2004.                                                                                                                 
|                |  |              
|(26)            |  | 3.1.3         |  | Certificate of Ownership and Merger, filed September 6, 2005.                                                                                                                                                           
|                |  |              
|(9)             |  | 3.2           |  | Certificate of Designations, Preferences and Rights of Series A Convertible Preferred Stock, filed June 29, 2001.                                                                                                       
|                |  |              
|(9)             |  | 3.2.1         |  | Certificate of Correction to Certificate of Designations, Preferences and Rights of Series A Convertible Preferred Stock, filed July 23, 2001.                                                                          
|                |  |              
|(9)             |  | 3.3           |  | Certificate of Designations, Preferences and Rights of Series B Convertible Preferred Stock, filed March 22, 2002.                                                                                                      
|                |  |              
|(9)             |  | 3.4           |  | Certificate of Designations, Preferences and Rights of Series C Convertible Preferred Stock, filed November 15, 2002.                                                                                                   
|                |  |              
|(9)             |  | 3.4.1         |  | Certificate of Amendment to Certificate of Designations, Preferences and Rights of Series C Convertible Preferred Stock, filed February 4, 2003.                                                                        
|                |  |              
|(4)             |  | 3.5           |  | Bylaws, as currently in effect.                                                                                                                                                                                         
|                |  |              
|                |  | 4.1           |  | Reference is made to Exhibits 3.1 through 3.5.                                                                                                                                                                          
|                |  |              
|(26)            |  | 4.2           |  | Specimen Stock Certificate.                                                                                                                                                                                             



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|                |   |  |               |  |                                                                                                                                                  
|--------------- | - |  | ------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitFootnote |   |  | ExhibitNumber |  |                                                                                                                                                  
|(16)            |   |  | 4.3           |  | Contingent Value Rights Agreement, dated December 10, 2004, by and between ViroLogic, Inc., and U.S. Bank National Association as trustee.       
|                |   | 
|(1)             |   |  | 10.1          |  | Office Lease by and between ViroLogic and Oyster Point Tech Center LLC dated as of May 25, 1999.                                                 
|                |   | 
|(1)             |   |  | 10.2          |  | Office Lease by and between ViroLogic and Trammell Crow Northern California Development, Inc. dated as of November 23, 1999.                     
|                |   | 
|(1)             |   |  | 10.3          |  | Loan and Security Agreement by and between ViroLogic and MMC/ GATX Partnership No. 1 dated as of January 30, 1998.                               
|                |   | 
|(1)             |  |  | 10.4          |  | Employment Agreement by and between ViroLogic and William D. Young dated September 29, 1999.                                                     
|                |   | 
|(1)             |  |  | 10.5          |  | 2000 Employee Stock Purchase Plan and related offering documents.                                                                                
|                |   | 
|(1)             |   |  | 10.6          |  | Equipment Financing Agreement dated March 28, 2000 with Pentech Financial Services, Inc.                                                         
|                |   | 
|(2)             |  |  | 10.7          |  | ViroLogic, Inc. 2000 Equity Incentive Plan, as amended.                                                                                          
|                |   | 
|(3)             |  |  | 10.8          |  | Form of Executive Severance Benefits Agreement.                                                                                                  
|                |   | 
|(3)             |   |  | 10.9          |  | Master Lease Agreement dated September 14, 2000 by and between ViroLogic, Inc. and General Electric Capital Corporation.                         
|                |   | 
|(4)             |   |  | 10.10         |  | Equipment Financing Agreement by and between ViroLogic and De Lage Landen Financial Services, Inc. dated as of January 29, 2001.                 
|                |   | 
|(5)             |   |  | 10.11         |  | Equipment Schedule No. 4 to Master Lease Agreement dated as of August 14, 2000 by and between ViroLogic and General Electric Capital Corporation.
|                |   | 
|(5)             |   |  | 10.12         |  | Sublease by and between ViroLogic, Inc. and Raven Biotechnologies, Inc.                                                                          
|                |   | 
|(1)             |  |  | 10.13         |  | Form of Indemnity Agreement between the Company and its directors and officers.                                                                  
|                |   | 
|(1)             |  |  | 10.14         |  | Form of Stock Option Agreement under the 2000 Equity Incentive Plan for options granted prior to May 1, 2000.                                    
|                |   | 
|(1)             |  |  | 10.15         |  | Form of Stock Option Agreement Pursuant to the 2000 Equity Incentive Plan for options granted after May 1, 2000.                                 
|                |   | 
|(10)            |   |  | 10.16         |  | Equipment Schedule No. 5 to Master Lease Agreement dated as of August 14, 2000 by and between ViroLogic and General Electric Capital Corporation.
|                |   | 
|(6)             |   |  | 10.17         |  | Form of (Common) Stock Purchase Warrant issued to holders of Series A Redeemable Convertible Preferred Stock.                                    
|                |   | 
|(7)             |   |  | 10.18         |  | Sublease, dated as of June 1, 2002, by and between ViroLogic, Inc. and diaDexus, Inc.                                                            
|                |   | 
|(8)             |   |  | 10.19         |  | Form of Stock Purchase Warrant issued to purchasers of Series C Preferred Stock.                                                                 
|                |   | 
|(8)             |   |  | 10.20         |  | Form of Stock Purchase Warrant issued to purchasers of Series B Preferred Stock.                                                                 
|                |   | 
|(11)            |   |  | 10.21         |  | First Amendment to Sublease, dated as of August 21, 2003, by and between diaDexus, Inc and ViroLogic, Inc.                                       
|                |   | 
|(14)            |   |  | 10.22         |  | Lease Termination Agreement, dated as of March 22, 2004, by and between Britannia Pointe Grand Limited Partnership and ViroLogic, Inc.           



100



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|                |   |  |               |  |                                                                                                                                                                                           
|--------------- | - |  | ------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitFootnote |   |  | ExhibitNumber |  |                                                                                                                                                                                           
|(15)            |   |  | 10.23         |  | Second Amendment to Sublease, dated as of October 1, 2004, between diaDexus, Inc and ViroLogic, Inc.                                                                                      
|                |   | 
|(18)            |  |  | 10.24         |  | ViroLogic, Inc. 2004 Equity Incentive Plan.                                                                                                                                               
|                |   | 
|(13)            |   |  | 10.25         |  | Registration Rights Agreement, dated as of October 18, 2004, by and among ViroLogic, Inc. and certain entities affiliated with Tang Capital Partners, L.P. and Perry Corp.                
|                |   | 
|(17)            |  |  | 10.26         |  | Form of Option Agreement under the ViroLogic, Inc. 2004 Equity Incentive Plan.                                                                                                            
|                |   | 
|(20)            |   |  | 10.27         |  | Lease Agreement, dated March 1, 1999, between ACLARA BioSciences, Inc. and The Pear Avenue Group.                                                                                         
|                |   | 
|(21)            |  |  | 10.28         |  | Form of Change of Control Agreement between ACLARA BioSciences, Inc. and Alfred Merriweather.                                                                                             
|                |   | 
|(22)            |  |  | 10.29         |  | Employment Letter Agreement, dated April 11, 2003, between ACLARA BioSciences, Inc and Michael J. Dunn.                                                                                   
|                |   | 
|(22)            |  |  | 10.30         |  | Severance Agreement, dated April 11, 2003, between ACLARA BioSciences, Inc. and Michael J. Dunn.                                                                                          
|                |   | 
|(20)            |  |  | 10.31         |  | ACLARA BioSciences, Inc. Amended and Restated 1997 Stock Plan.                                                                                                                            
|                |   | 
|(23)            |  |  | 10.32         |  | ACLARA BioSciences, Inc. NQ03 Stock Plan Non-Statutory Stock Option Agreement.                                                                                                            
|                |   | 
|(24)            |  |  | 10.33         |  | Form of Amendment to Stock Option Agreement between ACLARA BioSciences, Inc. and each of Alfred Merriweather and Michael Dunn.                                                            
|                |   | 
|(27)            |  |  | 10.34         |  | ViroLogic, Inc. 2005 Bonus Plan Description.                                                                                                                                              
|                |   | 
|(27)            |  |  | 10.35         |  | ViroLogic, Inc. Non-Employee Director Cash Compensation Arrangements.                                                                                                                     
|                |   | 
|(28)            | * |  | 10.36         |  | Referral Testing Agreement, between Monogram Biosciences, Inc. and Quest Diagnostics Incorporated, dated October 1, 2005.                                                                 
|                |   | 
|(29)            |   |  | 10.37         |  | Confidential Separation and Release Agreement between Monogram Biosciences, Inc. and Sharat Singh dated September 28, 2005.                                                               
|                |   | 
|(30)            |   |  | 10.38         |  | Note Purchase Agreement, dated May 5, 2006, by and between Pfizer Inc. and Monogram Biosciences, Inc.                                                                                     
|                |   | 
|(30)            |   |  | 10.39         |  | Monogram Biosciences, Inc. 3.0% Senior Secured Convertible Note Due May 19, 2010, issued to Pfizer Inc.                                                                                   
|                |   | 
|(30)            |   |  | 10.40         |  | Note Security Agreement, dated May 5, 2006, by and between Monogram Biosciences, Inc. and Pfizer, Inc.                                                                                    
|                |   | 
|(31)            |   |  | 10.41         |  | Collaboration Agreement, dated May 5, 2006, by and between Pfizer Inc. and Monogram Biosciences, Inc.                                                                                     
|                |   | 
|(31)            | * |  | 10.42         |  | Collaboration Agreement, dated May 5, 2006, by and between Pfizer Inc. and Monogram Biosciences, Inc.                                                                                     
|                |   | 
|(32)            |   |  | 10.43         |  | Credit and Security Agreement, dated September 29, 2006, by and between Merrill Lynch Capital, a division of Merrill Lynch Business Financial Services Inc. and Monogram Biosciences,
Inc.
|                |   | 
|                |  |  | 10.44         |  | Monogram Non-Qualified Deferred Compensation Plan, effective January 1, 2007.                                                                                                             



101



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##### Table of Contents

|                |  |               |  |                                                                                                                                                                                                    
|--------------- |  | ------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitFootnote |  | ExhibitNumber |  |                                                                                                                                                                                                    
|                |  | 23.1          |  | Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.                                                                                                              
|                |  |              
|                |  | 23.2          |  | Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm.                                                                                                                       
|                |  |              
|                |  | 24.1          |  | Power of Attorney is contained on the signature page.                                                                                                                                              
|                |  |              
|                |  | 31.1          |  | Certification of Chief Executive Officer pursuant to Rule 13a-14(A) or Rule 15d-14(A) promulgated under the Securities Exchange Act of 1934.                                                       
|                |  |              
|                |  | 31.2          |  | Certification of Chief Financial Officer pursuant to Rule 13a-14(A) or Rule 15d-14(A) promulgated under the Securities Exchange Act of 1934.                                                       
|                |  |              
|                |  | 32.1          |  | Certification of Chief Executive Officer and Chief Financial Officer pursuant to 18 U.S.C. Section 1350 and Rule 13a-14(B) or Rule 15d-14(B) promulgated under the Securities Exchange Act of
1934.

---

| | Indicates management or compensatory plan or arrangement.
|- | ---------------------------------------------------------

|(*) | Confidential treatment has been requested for portions of this document, which are omitted and filed separately with the SEC.
|--- | -----------------------------------------------------------------------------------------------------------------------------

|(1) | Filed as an exhibit to our Registration Statement on Form S-1 (No. 333-30896) or amendments thereto and incorporated herein by reference.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------

|(2) | Filed as an exhibit to our Registrants Quarterly Report on Form 10-Q for the quarter ended September 30, 2000 and incorporated herein by reference.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 2000 and incorporated herein by reference.
|--- | --------------------------------------------------------------------------------------------------------------------------------

|(4) | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended March 31, 2001 and incorporated herein by reference.
|--- | -----------------------------------------------------------------------------------------------------------------------------------

|(5) | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2001 and incorporated herein by reference.
|--- | ----------------------------------------------------------------------------------------------------------------------------------

|(6) | Filed as an exhibit to our Current Report on Form 8-K filed on March 26, 2002 and incorporated herein by reference.
|--- | -------------------------------------------------------------------------------------------------------------------

|(7) | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2002 and incorporated herein by reference.
|--- | ----------------------------------------------------------------------------------------------------------------------------------

|(8) | Filed as an exhibit to our Current Report on Form 8-K filed on November 25, 2002 and incorporated herein by reference.
|--- | ----------------------------------------------------------------------------------------------------------------------

|(9) | Filed as an exhibit to our Registration Statement on Form S-3 (No. 333-102995) and incorporated herein by reference.
|--- | --------------------------------------------------------------------------------------------------------------------

|(10) | Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 2001 and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------------------

|(11) | Filed as an exhibit to our Quarterly Report on Form 10-Q for the Quarter ended September 30, 2003 and incorporated herein by reference.
|---- | ---------------------------------------------------------------------------------------------------------------------------------------

|(12) | Filed as an exhibit to our Current Report on Form 8-K filed on June 1, 2004 and incorporated herein by reference.
|---- | -----------------------------------------------------------------------------------------------------------------

|(13) | Filed as an exhibit to our Current Report on Form 8-K filed on October 19, 2004 and incorporated herein by reference.
|---- | ---------------------------------------------------------------------------------------------------------------------

|(14) | Filed as an exhibit to our Quarterly Report of Form 10-Q for the quarter ended March 31, 2004 and incorporated herein by reference.
|---- | -----------------------------------------------------------------------------------------------------------------------------------

|(15) | Filed as an exhibit to our Current Report on Form 8-K filed on November 4, 2004 and incorporated herein by reference.
|---- | ---------------------------------------------------------------------------------------------------------------------

|(16) | Filed as an exhibit to our Current Report on Form 8-K filed on December 10, 2004 and incorporated herein by reference.
|---- | ----------------------------------------------------------------------------------------------------------------------



102



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##### Table of Contents

|(17) | Filed as an exhibit to our Current Report on Form 8-K filed on December 22, 2004 and incorporated herein by reference.
|---- | ----------------------------------------------------------------------------------------------------------------------

|(18) | Filed as an exhibit to our Registration Statement on Form S-8 (No. 333-121437) filed on December 20, 2004 and incorporated herein by reference.
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------

|(19) | Filed as an exhibit to our Registration Statement on Form S-4 (No. 333-120211) and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------

|(20) | Filed as an exhibit to ACLARA BioSciences, Inc. Registration Statement on Form S-1 (No. 333-95107) or amendments thereto and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------------------------------------------------

|(21) | Filed as an exhibit to ACLARA BioSciences, Inc. Annual Report on Form 10-K for the year ended December 31, 2002 and incorporated herein by reference.
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------

|(22) | Filed as an exhibit to ACLARA BioSciences, Inc. Quarterly Report on Form 10-Q for the quarter ended June 30, 2003 and incorporated herein by reference.
|---- | -------------------------------------------------------------------------------------------------------------------------------------------------------

|(23) | Filed as an exhibit to ACLARA BioSciences, Inc. Annual Report on Form 10-K for the year ended December 31, 2003 and incorporated herein by reference.
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------

|(24) | Filed as an exhibit to ACLARA BioSciences, Inc. Quarterly Report on Form 10-Q for the quarter ended June 30, 2004 and incorporated herein by reference.
|---- | -------------------------------------------------------------------------------------------------------------------------------------------------------

|(25) | Filed as an exhibit to our Quarterly Report on Form 10-Q for the Quarter ended June 30, 2004 and incorporated herein by reference.
|---- | ----------------------------------------------------------------------------------------------------------------------------------

|(26) | Filed as an exhibit to our Current Report on Form 8-K filed on September 8, 2005 and incorporated herein by reference.
|---- | ----------------------------------------------------------------------------------------------------------------------

|(27) | Filed as an exhibit to our Quarterly Report on Form 10-Q for the Quarter ended March 31, 2005 and incorporated herein by reference.
|---- | -----------------------------------------------------------------------------------------------------------------------------------

|(28) | Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 2005 and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------------------

|(29) | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended March 31, 2006 and incorporated herein by reference.
|---- | -----------------------------------------------------------------------------------------------------------------------------------

|(30) | Filed as an exhibit to our Registration Statement on Form S-3 (No. 333-135096) filed on June 16, 2006 and incorporated herein by reference.
|---- | -------------------------------------------------------------------------------------------------------------------------------------------

|(31) | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2006 and incorporated herein by reference.
|---- | ----------------------------------------------------------------------------------------------------------------------------------

|(32) | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended September 30, 2006 and incorporated herein by reference.
|---- | ---------------------------------------------------------------------------------------------------------------------------------------



103



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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934,
the Registrant has duly caused this Report to be signed on its behalf by the undersigned, thereunto duly authorized.



Monogram Biosciences, Inc.By:

/S/    WILLIAM D.
YOUNGWilliam D. Young Chief Executive Officer


Date: March 9, 2007

POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears
below constitutes and appoints William D. Young, Kathy L. Hibbs and Alfred G. Merriweather, and each of them, as his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or her and in his
or her name, place, and stead, in any and all capacities, to sign any and all amendments to this Report, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission,
granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she
might or could do in person, hereby ratifying and confirming that all said attorneys-in-fact and agents, or any of them or their or his substitute or substituted, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Exchange Act of 1934, this Report has been signed below by the following persons on behalf of the
Registrant and in the capacities and on the dates indicated.



|                                                                  |  |                                                                                         |  |              
|----------------------------------------------------------------- |  | --------------------------------------------------------------------------------------- |  | -------------
|Signatures                                                        |  | Title                                                                                   |  | Date         
|                                                                  |  |                                                                                        
|/S/    WILLIAM D.
YOUNG William D. Young                          |  | Chairman, Chief Executive Officer and Director (Principal Executive Officer)            |  | March 9, 2007
|                                                                  |  |                                                                                        
|/s/    ALFRED G.
MERRIWEATHER Alfred G. Merriweather              |  | Vice President and Chief Financial Officer (Principal Financial and Accounting Officer) |  | March 9, 2007
|                                                                  |  |                                                                                        
|/s/    THOMAS R.
BARUCH Thomas R. Baruch                          |  | Director                                                                                |  | March 9, 2007
|                                                                  |  |                                                                                        
|/s/    EDMON
JENNINGS Edmon Jennings                              |  | Director                                                                                |  | March 9, 2007
|                                                                  |  |                                                                                        
|/s/    WILLIAM JENKINS,
M.D. William Jenkins, M.D.                |  | Director                                                                                |  | March 9, 2007
|                                                                  |  |                                                                                        
|/s/    CRISTINA H.
KEPNER Cristina H. Kepner                      |  | Director                                                                                |  | March 9, 2007
|                                                                  |  |                                                                                        
|/s/    DAVID H. PERSING M.D., PH.D. David H. Persing, M.D., Ph.D. |  | Director                                                                                |  | March 9, 2007
|                                                                  |  |                                                                                        
|John D. Mendlein, Ph.D., J.D.                                     |  | Director                                                                                |  |              



104



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##### Table of Contents

SCHEDULE II  VALUATION AND QUALIFYING ACCOUNTS

(IN THOUSANDS)



|                                 |  |                              |       |                                                 |   |            |  |   |                        |   |  |   |      
|-------------------------------- |  | ---------------------------- | ----- | ----------------------------------------------- | - | ---------- |  | - | ---------------------- | - |  | - | -----
|Classification                   |  | Balance atBeginning ofPeriod |       | Additions Chargedto Operating Costsand Expenses |   | Deductions |  |   | Balance atEnd ofPeriod
|Allowance for doubtful accounts: |  |                              |       |                                                 |   |            |  |   |                        |   |  |   |      
|Year ended December 31, 2006     |  | $                            | 1,044 |                                                 | $ | 357        |  | $ | (436                   | ) |  | $ | 965  
|Year ended December 31, 2005     |  | $                            | 595   |                                                 | $ | 826        |  | $ | (377                   | ) |  | $ | 1,044
|Year ended December 31, 2004     |  | $                            | 643   |                                                 | $ | 319        |  | $ | (367                   | ) |  | $ | 595  



S-1



---

##### Table of Contents

EXHIBIT INDEX



|                |   |  |               |  |                                                                                                                                                                                                                         
|--------------- | - |  | ------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitFootnote |   |  | ExhibitNumber |  |                                                                                                                                                                                                                         
|(12)            |   |  | 2.1           |  | Agreement and Plan of Merger and Reorganization, dated as of May 28, 2004, by and among ViroLogic, Inc., Apollo Acquisition Sub, Inc., Apollo Merger Subsidiary, LLC and ACLARA BioSciences,
Inc.                       
|                |   | 
|(13)            |   |  | 2.2           |  | Amendment No. 1 to Agreement and Plan of Merger and Reorganization, dated as of October 18, 2004, by and among ViroLogic, Inc., Apollo Acquisition Sub, Inc., Apollo Merger Subsidiary, LLC and
ACLARA BioSciences, Inc.
|                |   | 
|(9)             |   |  | 3.1           |  | Amended and Restated Certificate of Incorporation, filed July 17, 2000.                                                                                                                                                 
|                |   | 
|(9)             |   |  | 3.1.1         |  | Certificate of Amendment to Amended and Restated Certificate of Incorporation, filed February 4, 2003.                                                                                                                  
|                |   | 
|(16)            |   |  | 3.1.2         |  | Certificate of Amendment to Amended and Restated Certificate of Incorporation, filed December 10, 2004.                                                                                                                 
|                |   | 
|(26)            |   |  | 3.1.3         |  | Certificate of Ownership and Merger, filed September 6, 2005.                                                                                                                                                           
|                |   | 
|(9)             |   |  | 3.2           |  | Certificate of Designations, Preferences and Rights of Series A Convertible Preferred Stock, filed June 29, 2001.                                                                                                       
|                |   | 
|(9)             |   |  | 3.2.1         |  | Certificate of Correction to Certificate of Designations, Preferences and Rights of Series A Convertible Preferred Stock, filed July 23, 2001.                                                                          
|                |   | 
|(9)             |   |  | 3.3           |  | Certificate of Designations, Preferences and Rights of Series B Convertible Preferred Stock, filed March 22, 2002.                                                                                                      
|                |   | 
|(9)             |   |  | 3.4           |  | Certificate of Designations, Preferences and Rights of Series C Convertible Preferred Stock, filed November 15, 2002.                                                                                                   
|                |   | 
|(9)             |   |  | 3.4.1         |  | Certificate of Amendment to Certificate of Designations, Preferences and Rights of Series C Convertible Preferred Stock, filed February 4, 2003.                                                                        
|                |   | 
|(4)             |   |  | 3.5           |  | Bylaws, as currently in effect.                                                                                                                                                                                         
|                |   | 
|                |   |  | 4.1           |  | Reference is made to Exhibits 3.1 through 3.5.                                                                                                                                                                          
|                |   | 
|(26)            |   |  | 4.2           |  | Specimen Stock Certificate.                                                                                                                                                                                             
|                |   | 
|(16)            |   |  | 4.3           |  | Contingent Value Rights Agreement, dated December 10, 2004, by and between ViroLogic, Inc., and U.S. Bank National Association as trustee.                                                                              
|                |   | 
|(1)             |   |  | 10.1          |  | Office Lease by and between ViroLogic and Oyster Point Tech Center LLC dated as of May 25, 1999.                                                                                                                        
|                |   | 
|(1)             |   |  | 10.2          |  | Office Lease by and between ViroLogic and Trammell Crow Northern California Development, Inc. dated as of November 23, 1999.                                                                                            
|                |   | 
|(1)             |   |  | 10.3          |  | Loan and Security Agreement by and between ViroLogic and MMC/ GATX Partnership No. 1 dated as of January 30, 1998.                                                                                                      
|                |   | 
|(1)             |  |  | 10.4          |  | Employment Agreement by and between ViroLogic and William D. Young dated September 29, 1999.                                                                                                                            
|                |   | 
|(1)             |  |  | 10.5          |  | 2000 Employee Stock Purchase Plan and related offering documents.                                                                                                                                                       
|                |   | 
|(1)             |   |  | 10.6          |  | Equipment Financing Agreement dated March 28, 2000 with Pentech Financial Services, Inc.                                                                                                                                
|                |   | 
|(2)             |  |  | 10.7          |  | ViroLogic, Inc. 2000 Equity Incentive Plan, as amended.                                                                                                                                                                 



---

##### Table of Contents

|                |   |  |               |  |                                                                                                                                                                           
|--------------- | - |  | ------------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitFootnote |   |  | ExhibitNumber |  |                                                                                                                                                                           
|(3)             |  |  | 10.8          |  | Form of Executive Severance Benefits Agreement.                                                                                                                           
|                |   | 
|(3)             |   |  | 10.9          |  | Master Lease Agreement dated September 14, 2000 by and between ViroLogic, Inc. and General Electric Capital Corporation.                                                  
|                |   | 
|(4)             |   |  | 10.10         |  | Equipment Financing Agreement by and between ViroLogic and De Lage Landen Financial Services, Inc. dated as of January 29, 2001.                                          
|                |   | 
|(5)             |   |  | 10.11         |  | Equipment Schedule No. 4 to Master Lease Agreement dated as of August 14, 2000 by and between ViroLogic and General Electric Capital Corporation.                         
|                |   | 
|(5)             |   |  | 10.12         |  | Sublease by and between ViroLogic, Inc. and Raven Biotechnologies, Inc.                                                                                                   
|                |   | 
|(1)             |  |  | 10.13         |  | Form of Indemnity Agreement between the Company and its directors and officers.                                                                                           
|                |   | 
|(1)             |  |  | 10.14         |  | Form of Stock Option Agreement under the 2000 Equity Incentive Plan for options granted prior to May 1, 2000.                                                             
|                |   | 
|(1)             |  |  | 10.15         |  | Form of Stock Option Agreement Pursuant to the 2000 Equity Incentive Plan for options granted after May 1, 2000.                                                          
|                |   | 
|(10)            |   |  | 10.16         |  | Equipment Schedule No. 5 to Master Lease Agreement dated as of August 14, 2000 by and between ViroLogic and General Electric Capital Corporation.                         
|                |   | 
|(6)             |   |  | 10.17         |  | Form of (Common) Stock Purchase Warrant issued to holders of Series A Redeemable Convertible Preferred Stock.                                                             
|                |   | 
|(7)             |   |  | 10.18         |  | Sublease, dated as of June 1, 2002, by and between ViroLogic, Inc. and diaDexus, Inc.                                                                                     
|                |   | 
|(8)             |   |  | 10.19         |  | Form of Stock Purchase Warrant issued to purchasers of Series C Preferred Stock.                                                                                          
|                |   | 
|(8)             |   |  | 10.20         |  | Form of Stock Purchase Warrant issued to purchasers of Series B Preferred Stock.                                                                                          
|                |   | 
|(11)            |   |  | 10.21         |  | First Amendment to Sublease, dated as of August 21, 2003, by and between diaDexus, Inc and ViroLogic, Inc.                                                                
|                |   | 
|(14)            |   |  | 10.22         |  | Lease Termination Agreement, dated as of March 22, 2004, by and between Britannia Pointe Grand Limited Partnership and ViroLogic, Inc.                                    
|                |   | 
|(15)            |   |  | 10.23         |  | Second Amendment to Sublease, dated as of October 1, 2004, between diaDexus, Inc and ViroLogic, Inc.                                                                      
|                |   | 
|(18)            |  |  | 10.24         |  | ViroLogic, Inc. 2004 Equity Incentive Plan.                                                                                                                               
|                |   | 
|(13)            |   |  | 10.25         |  | Registration Rights Agreement, dated as of October 18, 2004, by and among ViroLogic, Inc. and certain entities affiliated with Tang Capital Partners, L.P. and Perry Corp.
|                |   | 
|(17)            |  |  | 10.26         |  | Form of Option Agreement under the ViroLogic, Inc. 2004 Equity Incentive Plan.                                                                                            
|                |   | 
|(20)            |   |  | 10.27         |  | Lease Agreement, dated March 1, 1999, between ACLARA BioSciences, Inc. and The Pear Avenue Group.                                                                         
|                |   | 
|(21)            |  |  | 10.28         |  | Form of Change of Control Agreement between ACLARA BioSciences, Inc. and Alfred Merriweather.                                                                             
|                |   | 
|(22)            |  |  | 10.29         |  | Employment Letter Agreement, dated April 11, 2003, between ACLARA BioSciences, Inc and Michael J. Dunn.                                                                   
|                |   | 
|(22)            |  |  | 10.30         |  | Severance Agreement, dated April 11, 2003, between ACLARA BioSciences, Inc. and Michael J. Dunn.                                                                          
|                |   | 
|(20)            |  |  | 10.31         |  | ACLARA BioSciences, Inc. Amended and Restated 1997 Stock Plan.                                                                                                            
|                |   | 
|(23)            |  |  | 10.32         |  | ACLARA BioSciences, Inc. NQ03 Stock Plan Non-Statutory Stock Option Agreement.                                                                                            



---

##### Table of Contents

|                |   |  |               |  |                                                                                                                                                                                                    
|--------------- | - |  | ------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitFootnote |   |  | ExhibitNumber |  |                                                                                                                                                                                                    
|(24)            |  |  | 10.33         |  | Form of Amendment to Stock Option Agreement between ACLARA BioSciences, Inc. and each of Alfred Merriweather and Michael Dunn.                                                                     
|                |   | 
|(27)            |  |  | 10.34         |  | ViroLogic, Inc. 2005 Bonus Plan Description.                                                                                                                                                       
|                |   | 
|(27)            |  |  | 10.35         |  | ViroLogic, Inc. Non-Employee Director Cash Compensation Arrangements.                                                                                                                              
|                |   | 
|(28)            | * |  | 10.36         |  | Referral Testing Agreement, between Monogram Biosciences, Inc. and Quest Diagnostics Incorporated, dated October 1, 2005.                                                                          
|                |   | 
|(29)            |   |  | 10.37         |  | Confidential Separation and Release Agreement between Monogram Biosciences, Inc. and Sharat Singh dated September 28, 2005.                                                                        
|                |   | 
|(30)            |   |  | 10.38         |  | Note Purchase Agreement, dated May 5, 2006, by and between Pfizer Inc. and Monogram Biosciences, Inc.                                                                                              
|                |   | 
|(30)            |   |  | 10.39         |  | Monogram Biosciences, Inc. 3.0% Senior Secured Convertible Note Due May 19, 2010, issued to Pfizer Inc.                                                                                            
|                |   | 
|(30)            |   |  | 10.40         |  | Note Security Agreement, dated May 5, 2006, by and between Monogram Biosciences, Inc. and Pfizer, Inc.                                                                                             
|                |   | 
|(31)            |   |  | 10.41         |  | Collaboration Agreement, dated May 5, 2006, by and between Pfizer Inc. and Monogram Biosciences, Inc.                                                                                              
|                |   | 
|(31)            | * |  | 10.42         |  | Collaboration Agreement, dated May 5, 2006, by and between Pfizer Inc. and Monogram Biosciences, Inc.                                                                                              
|                |   | 
|(32)            |   |  | 10.43         |  | Credit and Security Agreement, dated September 29, 2006, by and between Merrill Lynch Capital, a division of Merrill Lynch Business Financial Services Inc. and Monogram Biosciences,
Inc.         
|                |   | 
|                |  |  | 10.44         |  | Monogram Non-Qualified Deferred Compensation Plan, effective January 1, 2007.                                                                                                                      
|                |   | 
|                |   |  | 23.1          |  | Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.                                                                                                              
|                |   | 
|                |   |  | 23.2          |  | Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm.                                                                                                                       
|                |   | 
|                |   |  | 24.1          |  | Power of Attorney is contained on the signature page.                                                                                                                                              
|                |   | 
|                |   |  | 31.1          |  | Certification of Chief Executive Officer pursuant to Rule 13a-14(A) or Rule 15d-14(A) promulgated under the Securities Exchange Act of 1934.                                                       
|                |   | 
|                |   |  | 31.2          |  | Certification of Chief Financial Officer pursuant to Rule 13a-14(A) or Rule 15d-14(A) promulgated under the Securities Exchange Act of 1934.                                                       
|                |   | 
|                |   |  | 32.1          |  | Certification of Chief Executive Officer and Chief Financial Officer pursuant to 18 U.S.C. Section 1350 and Rule 13a-14(B) or Rule 15d-14(B) promulgated under the Securities Exchange Act of
1934.

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|    |  |                                                                                                                                                     
|--- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------
|   |  | Indicates management or compensatory plan or arrangement.                                                                                           
|(*) |  | Confidential treatment has been requested for portions of this document, which are omitted and filed separately with the SEC.                       
|(1) |  | Filed as an exhibit to our Registration Statement on Form S-1 (No. 333-30896) or amendments thereto and incorporated herein by reference.           
|(2) |  | Filed as an exhibit to our Registrants Quarterly Report on Form 10-Q for the quarter ended September 30, 2000 and incorporated herein by reference.



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##### Table of Contents

|     |  |                                                                                                                                                               
|---- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------
|(3)  |  | Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 2000 and incorporated herein by reference.                              
|(4)  |  | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended March 31, 2001 and incorporated herein by reference.                           
|(5)  |  | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2001 and incorporated herein by reference.                            
|(6)  |  | Filed as an exhibit to our Current Report on Form 8-K filed on March 26, 2002 and incorporated herein by reference.                                           
|(7)  |  | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2002 and incorporated herein by reference.                            
|(8)  |  | Filed as an exhibit to our Current Report on Form 8-K filed on November 25, 2002 and incorporated herein by reference.                                        
|(9)  |  | Filed as an exhibit to our Registration Statement on Form S-3 (No. 333-102995) and incorporated herein by reference.                                          
|(10) |  | Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 2001 and incorporated herein by reference.                              
|(11) |  | Filed as an exhibit to our Quarterly Report on Form 10-Q for the Quarter ended September 30, 2003 and incorporated herein by reference.                       
|(12) |  | Filed as an exhibit to our Current Report on Form 8-K filed on June 1, 2004 and incorporated herein by reference.                                             
|(13) |  | Filed as an exhibit to our Current Report on Form 8-K filed on October 19, 2004 and incorporated herein by reference.                                         
|(14) |  | Filed as an exhibit to our Quarterly Report of Form 10-Q for the quarter ended March 31, 2004 and incorporated herein by reference.                           
|(15) |  | Filed as an exhibit to our Current Report on Form 8-K filed on November 4, 2004 and incorporated herein by reference.                                         
|(16) |  | Filed as an exhibit to our Current Report on Form 8-K filed on December 10, 2004 and incorporated herein by reference.                                        
|(17) |  | Filed as an exhibit to our Current Report on Form 8-K filed on December 22, 2004 and incorporated herein by reference.                                        
|(18) |  | Filed as an exhibit to our Registration Statement on Form S-8 (No. 333-121437) filed on December 20, 2004 and incorporated herein by reference.               
|(19) |  | Filed as an exhibit to our Registration Statement on Form S-4 (No. 333-120211) and incorporated herein by reference.                                          
|(20) |  | Filed as an exhibit to ACLARA BioSciences, Inc. Registration Statement on Form S-1 (No. 333-95107) or amendments thereto and incorporated herein by reference.
|(21) |  | Filed as an exhibit to ACLARA BioSciences, Inc. Annual Report on Form 10-K for the year ended December 31, 2002 and incorporated herein by reference.         
|(22) |  | Filed as an exhibit to ACLARA BioSciences, Inc. Quarterly Report on Form 10-Q for the quarter ended June 30, 2003 and incorporated herein by reference.       
|(23) |  | Filed as an exhibit to ACLARA BioSciences, Inc. Annual Report on Form 10-K for the year ended December 31, 2003 and incorporated herein by reference.         
|(24) |  | Filed as an exhibit to ACLARA BioSciences, Inc. Quarterly Report on Form 10-Q for the quarter ended June 30, 2004 and incorporated herein by reference.       
|(25) |  | Filed as an exhibit to our Quarterly Report on Form 10-Q for the Quarter ended June 30, 2004 and incorporated herein by reference.                            
|(26) |  | Filed as an exhibit to our Current Report on Form 8-K filed on September 8, 2005 and incorporated herein by reference.                                        
|(27) |  | Filed as an exhibit to our Quarterly Report on Form 10-Q for the Quarter ended March 31, 2005 and incorporated herein by reference.                           
|(28) |  | Filed as an exhibit to our Annual Report on Form 10-K for the year ended December 31, 2005 and incorporated herein by reference.                              



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##### Table of Contents

|     |  |                                                                                                                                            
|---- |  | -------------------------------------------------------------------------------------------------------------------------------------------
|(29) |  | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended March 31, 2006 and incorporated herein by reference.        
|(30) |  | Filed as an exhibit to our Registration Statement on Form S-3 (No. 333-135096) filed on June 16, 2006 and incorporated herein by reference.
|(31) |  | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended June 30, 2006 and incorporated herein by reference.         
|(32) |  | Filed as an exhibit to our Quarterly Report on Form 10-Q for the quarter ended September 30, 2006 and incorporated herein by reference.