Exhibit 10.1


 





	DATED	5 February 2018



 





 



 




RULES OF THE VACCITECH LIMITED

EMI SHARE OPTION SCHEME

(APPROVED BY THE BOARD OF DIRECTORS ON 5 February 2018)







 





 



 





	5 New Street Square | London EC4A 3TW

                           Tel +44 (0)20 7300 7000

Fax +44 (0)20 7300 7100

DX 41 London

www.taylorwessing.com
	



 






     


     


    

 


INDEX


 


	Clause
    No.	 	Page
    No.



 


	1.	Interpretation
    and Construction	3
	2.	Statement of Purpose	8
	3.	Grant of Options	9
	4.	Notice of Grant	10
	5.	EMI Options: Limit
    for individual Eligible Employee	10
	6.	Overall limits for
    Company on the Grant of Options	10
	7.	Ordinary Share Capital	11
	8.	Non-Transferable	11
	9.	Rights to Exercise
    Options	11
	10.	Exercise of Options	12
	11.	Lapse of Options	14
	12.	Takeover, Reconstruction,
    Liquidation and Sale of the Business	15
	13.	Replacement Options	17
	14.	Loss of Office or Employment	19
	15.	Adjustments	20
	16.	General	21
	17. 	Overseas Employees	23
	18.	Supplementary Provisions	23
	schedule
    1	24
	schedule
    2	31
	schedule
    3	33



 






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INDEX

 


	Clause
    No.	 	Page
    No.



 


		1.	Interpretation and Construction



 


		1.1	Definitions



 


In the Rules, unless the context
requires otherwise, the following words and expressions are defined or otherwise explained by the provisions indicated:


 


	“Acquiring Company”	any company which has obtained Control of the Company in accordance with any of the provisions of Rule 12;
	“Adoption Date”	the date on which the Rules are adopted by the Directors;
	“Bad Leaver”	any director or employee of any Group Company who ceases to be a director or employee without becoming a director or employee of any other Group Company as a consequence of:
	 	(a)    Such director or employee’s dismissal for Cause; or
	 	(b)    Such director or employee’s resignation in circumstances where a Group Company would have been entitled to dismiss such director or employee for Cause, provided that, in each case, the Directors (acting with Investor Director Consent) may decide that that director or employee is not a Bad Leaver;
	“Cause”	in relation to a director or employee, that director or employee’s fraud or dishonesty, or having committed any crime punishable by imprisonment;
	“Committed Time”	the meaning given by paragraph 26 of Schedule 5;
	“Companies Act”	the Companies Act 2006;
	“Company”	Vaccitech Limited (registered number 09973585) whose registered office is at Magdalen Centre, 1 Robert Robinson Avenue, The Oxford Science Park, Oxford, Oxfordshire OX4 4GA;


 






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	“Compromise”	the meaning given by Rule 12.5;
	“Control”	shall mean the ability of a person to secure that the affairs of a company are conducted in accordance with the person’s wishes by the holding of shares or voting power in that or any other company (or as a result of any powers in the articles of association or other document relating to that or any other company) (in accordance with section 995 Income Tax Act 2007);
	“Date of Grant”	the date on which an Option is granted to an Employee;
	“Directors”	the board of Directors of the Company or a duly authorised committee thereof;
	“Disqualifying Event”	the meaning given by Sections 534 to 536 of ITEPA;
	“Eligible Employee”	any person who is an employee of the Company or any Qualifying Subsidiary PROVIDED THAT where an Option is intended to be an EMI Option the employee is an individual;
	 	(a)    whose Committed Time amounts to at least 25 hours a week, or if less, 75% of his Working Time; and
	 	(b)    who does not have a Material Interest in any Group Company;
	“EMI”	Enterprise Management Incentive;
	“EMI Option”	any right to acquire Shares:
	 	(a)    In relation to which the requirements of Schedule 5 are met at the Date of Grant; and
	 	(b)  of which Notice of Grant is given to HM Revenue & Customs in accordance with paragraph 44 of Schedule 5;
	 	and, where the circumstances permit, a Replacement Option in relation to that EMI Option;
	“Employee”	any individual who is an employee of a Group Company;



 






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	“Employer Company”	the company by reference to which the Option Holder is an Eligible Employee or Employee;
	“Employer’s NICs”	secondary Class 1 national insurance contributions;
	“Good Leaver”	any director or any employee of any Group Company who ceases to be a director or employee without becoming a director or employee of any other Group Company and is not a Bad Leaver;
	“Group” and “Group Company”	“Group”, in relation to a Parent Company, means that company and its Subsidiaries and “Group Company” shall be construed accordingly;
	“Independence Requirement”	the meaning given by paragraph 9 of Schedule 5;
	“Investor Director Consent”	shall have the meaning in the Articles of Association of the Company;
	“ITEPA”	the Income Tax (Earnings and Pensions) Act 2003;
	“Market Value”	shall be determined in accordance with Part VIII of the Taxation of Chargeable Gains Act 1992;
	“Material Interest”	the meaning given by paragraph 29 of Schedule 5;
	“Notice of Exercise”	a notice of exercise in accordance with the form set out in schedule 2 of the Rules or such other form as may be prescribed or required by the Directors from time to time;
	“Notice of Grant”	the notice of grant of the EMI Option submitted by the Employer Company to HM Revenue & Customs in accordance with Rule 4.1;
	“Option”	a right to acquire Shares which shall include an EMI Option or an Unapproved Option;



 






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	“Option Agreement ”	an agreement between the Company and an Eligible Employee (or the Company and an Employee) which shall evidence the grant of the Option, which shall be in accordance with the Rules of the Scheme and which shall be in such form as may be prescribed by the Directors;
	“Option Holder”	an Eligible Employee who has been granted an EMI Option or an Employee who has been granted an Unapproved Option (or his legal personal representatives where the circumstances permit);
	“Option Price”	the price per Share determined by the Directors which shall not be less than the Market Value of a Share on the Date of Grant (unless the Directors in their discretion decide otherwise) and, in the case of an Option which is a right to subscribe for Shares, not less than the nominal value of a Share;
	“Ordinary Share Capital”	the meaning given by section 989 of the Income Tax Act 2007;
	“Parent Company”	a company that has one or more Subsidiaries;
	“Personal Representatives” 	in relation to an Option Holder, the Option Holder’s legal personal representatives (being either the executors of his will to whom a valid grant of probate has been made or the duly appointed administrators of his estate) who in either case have provided the Directors with satisfactory evidence of their appointment;
	“Qualifying Exchange”	an exchange of Shares in accordance with Rule 13.3;
	“Qualifying Subsidiary”	the meaning given by paragraph 11 of Schedule 5 to ITEPA;
	“Relevant Company”	the company (being either the Company or any Group Company) which incurs a Tax Liability as set out in Rule 10.4;
	“Replacement Option”	an Option granted in accordance with Rule 13;
	“Restrictions”	any condition attaching to the Shares which makes the interest in the Shares restricted within the meaning of Chapter 2 of Part VII of ITEPA;
	“Rules”	these rules together with any schedules or appendices to these rules;



 






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	“Sale of the Business”	any transfer (whether through a single transaction or a series of transactions) of all or substantially all of the assets or undertaking of the Group (including goodwill) to any person (or persons connected with each other or act in concert with each other);
	“Schedule 5”	Schedule 5 to ITEPA;
	“Scheme”	this scheme as governed by the Rules;
	“Section 431 Election”	means an election in accordance with Section 431 of ITEPA being in the form as set out in Schedule 3 to this Scheme or in such other form as HM Revenue & Customs may determine from time to time;
	“Share”	Ordinary Shares in the capital of the Company (and in the context of an EMI Option, which satisfies the requirements of paragraph 35 of Schedule 5);
	“Subsidiary”	means any body corporate which is a subsidiary of the Company within the meaning of section 1159 of the Companies Act 2006;
	“Tax Liability”	a liability to account for any employee’s tax, national insurance, social security or other levies in respect of the Option (whether by reason of grant, exercise, or otherwise or by reason of a Disqualifying Event in relation to EMI Options only), including for the avoidance of doubt and without limitation any liability arising after the termination of the Option Holder’s employment for whatever reason and which:
	 	(a)    may arise or be incurred in any jurisdiction whatsoever and,
	 	(b)   by the law of the same jurisdiction may or shall be recovered from the person entitled to the Option;
	“Trading Activities Requirement”	the meaning given by paragraph 13 to 14 of Schedule 5;
	“Unapproved Options”	any right to acquire Shares granted pursuant to this Scheme which does not satisfy the requirements of Schedule 5;



 






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	“Unvested”	such number or the proportion of the Shares subject to an Option that are not Vested;
	“Vested”	such number or the proportion of the Shares subject to an Option that shall become vested according to the Vesting Schedule and “Vest” shall be construed accordingly;
	“Vesting Schedule”	the schedule set out in any Option Holder’s Option Agreement;
	“Working Time”	the meaning given by paragraph 27 of Schedule 5; and 
	“Working Time Declaration” 	means a written declaration made and signed by the Option Holder within the Option Agreement in accordance with paragraph 44(6) of Schedule 5 that he satisfies the Committed Time requirement.


 


		1.2	Construction



 


Words or expressions used herein
shall where appropriate:


 


(a)         
when denoting the masculine gender include the feminine and vice-versa;


 


(b)         
when denoting the singular include the plural and vice versa;


 


(c)        when
referring to any enactment be construed as a reference to that enactment as for the time being consolidated, amended, re-enacted
or replaced and shall include any regulations made thereunder;


 


(d)        
when a period of time is specified and starts from a given day or the day of an act or event, be calculated exclusive
of that day; and


 


(e)         
be construed such that the headings and sub-headings are for ease of reference only, and do not affect the interpretation
of any Rule;


 


(f)          
be construed where not otherwise defined in the Rules to have the same meanings as in Schedule 5.


 


		2.	Statement of Purpose



 


EMI Options granted at any time
pursuant to the Rules are granted for commercial reasons in order to recruit or retain an Eligible Employee and not as part of
a scheme or arrangement the main purpose, or one of the main purposes, of which is the avoidance of tax.


 






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		3.	Grant of Options



 


		3.1	General



 


(a)         
Subject to the Rules, the Company may, at any time, grant


 


(i)           
any Eligible Employee an EMI Option; or


 


(ii)          
any Employee an Unapproved Option


 


over such number of Shares at such
Option Price and with such conditions of exercise as the Company may determine.


 


(b)        
An EMI Option shall be granted in accordance with the provisions of Schedule


 


(c)         
EMI Options shall only be granted to individuals who are Eligible Employees.


 


(d)        
Unapproved Options shall only be granted to individuals who are Employees.


 


(e)         
An Option shall not be granted by any person other than the Company without the prior approval of the Directors.


 


		3.2	Contents of Option Agreement



 


The Option shall be agreed in
writing between the Company and the Option Holder, and shall state:


 


(a)         
the Date of Grant;


 


(b)         
that the EMI Option is granted under the provisions of Schedule 5;


 


(c)          
the number or maximum number of Shares over which the Option is granted;


 


(d)         
the Option Price, or the method by which the Option Price is to be determined;


 


(e)         
the Vesting Schedule, which shall provide that the Option shall Vest in four equal annual instalments from the Vesting
Commencement Date;


 


(f)          
the Vesting Commencement Date, which shall be either:


 


(i)           
the date on which the Option Holder became an Employee; or


 


(ii)          
the Date of Grant;


 


(g)         
details of any Restrictions attaching to the Shares and, if so, shall contain details of such Restrictions; and


 


(h)         
shall include the Working Time Declaration.


 


		3.3	The Option Agreement for an Unapproved Option shall be in the same form as Rule apart from Rule
3.2(b), (g) and (h) which shall not apply.



 






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		4.	Notice of Grant



 


		4.1	On the grant of an EMI Option, a Notice of Grant shall be given by the Employer Company to HM Revenue
& Customs within 92 days of the Date of Grant (or such further or other period as HM Revenue & Customs or statute may allow,
permit or require) and shall:



 


(a)         
be in such form and using such method as required by HM Revenue & Customs from time to time;


 


(b)         
contain a declaration by a director or the secretary of the Employer Company that:


 


(i)           
in his opinion the requirements of Schedule 5 are met;


 


(ii)          
the information provided is to the best of his knowledge correct and complete; and


 


(iii)          the
Option Holder has made and signed a Working Time Declaration and that the Working Time Declaration is held by the Employer Company;


 


(c)         
contain any other information that HMRC may require from time to time.


 


		4.2	On the grant of an Unapproved Option a Notice of Grant shall not be required.



 


		5.	EMI Options: Limit for individual Eligible Employee



 


		5.1	The number of Shares over which an EMI Option may be granted to any one Eligible Employee shall
be limited and take effect so that the total value of Shares (as determined by paragraphs 5(6) to (8) of Schedule 5) subject to
unexercised EMI Options granted to that Eligible Employee by the Company or any other Group Company does not exceed £250,000
(or such other limit as may apply from time to time in paragraph 5 of Schedule 5), SAVE WHERE an EMI Option is granted under the
provisions of Part 6 (Company Reorganisation) of Schedule 5.



 


		5.2	Provided that if an EMI Option exceeds the limit in Rule 5.1 the Option shall be treated as two
Options, one shall be an EMI Option as to the number of Shares within the limit in Rule 5.1 and the other Option shall be an Unapproved
Option.



 


		6.	Overall limits for Company on the Grant of Options



 


		6.1	Subject to such adjustments as may be made in accordance with Rule 15, no Option shall be granted
on any Date of Grant if as a result the total value of Shares of the Company (as determined by paragraphs 5(6) to (8) of Schedule
5) in respect of which unexercised EMI Options exist would exceed £3 million or such other limit as may apply from time to
time in paragraph 7 of Schedule 5.



 


		6.2	For the purpose of the limit contained in Rule 6.1 above, any Option or right which has been released,
cancelled or lapsed without being exercised shall be ignored.



 


		6.3	If following the purported grant of an EMI Option the limit in Rule 6.1 would be exceeded such
an Option shall not be an EMI Option insofar as it relates to the excess and the excess shall be treated as an Unapproved Option.



 






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	7.	Ordinary Share Capital



 


		7.1	Availability of Shares



 


The Company shall at all times
keep available Shares to satisfy the exercise to the full extent still possible of all Options which have neither lapsed nor been
fully exercised taking account of any other obligations of the Company to provide shares of the same class of Shares.


 


	8.	Non-Transferable



 


Save as provided in Rule 9.4,
no Option nor any right thereunder shall be capable of being transferred, assigned or charged in any manner whatsoever. Upon any
such purported transfer, assignment, or charge the Option shall immediately lapse and cease to be exercisable.


 


	9.	Rights to Exercise Options



 


	9.1	General



 


Subject to Rules 9.2, 9.3, 9.4
and 9.5 below an Option:


 


		(a)	shall not be exercisable before it has Vested in accordance
with the Vesting Schedule set out in the relevant Option Holder’s Option Agreement; and



 


		(b)	shall only be exercisable in accordance with Rule 12;
and



 


		(c)	shall not be exercised later than the day before the
tenth anniversary of the Date of Grant.



 


	9.2	Termination of Employment - Bad Leaver



 


If the Option Holder is a Bad
Leaver, the Option, whether Vested and unexercised or Unvested shall lapse immediately on the date upon which the Option Holder
ceases to hold employment or office within the Group, or in the case of termination for Cause, on the date of occurrence of such
Cause.


 


	9.3	Termination of Employment - Good Leaver



 


If the Option Holder is a Good
Leaver:


 


(a)         
the Option shall be exercisable to the extent Vested as at the date of ceasing employment:


 


(i)           
within 90 days of ceasing employment (or within any longer time period as referred to in section 532(1)(b) ITEPA);
or


 


(ii)          
in accordance with Rule 12.


 


(b)         the
Option to the extent Unvested shall lapse immediately on the date upon which the Option Holder ceases employment unless otherwise
decided by the Directors (acting with Investor Director Consent) before the date of cessation at their discretion. If the Directors
(acting with Investor Director Consent) use their discretion to permit exercise of the Unvested Option, it may be in relation
to part or all of the Unvested Option, but may only be exercisable within the time periods set out in Rule 9.3(a)(i) and Rule
9.3(a)(ii).


 






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	9.4	Death of the Option Holder



 


If an Option Holder dies,


 


		(a)	the Option shall be exercisable to the extent Vested
as at the date of the Option Holder’s death by the Option Holder’s Personal Representatives within 12 months of the
date of the Option Holder’s death; and



 


		(b)	the Option to the extent Unvested as at the date of the
Option Holder’s death shall lapse on the expiry of 12 months from the date of the Option Holder’s death and the Directors
(acting with Investor Director Consent) may use their discretion to permit exercise of part or all of the Unvested Option within
such 12 months period.



 


	9.5	Special exercise ten years from Date of Grant



 


Where there is no event as provided
for in Rule 12 which will occur within 10 years of the Date of Grant, an Option, to the extent Vested, may be exercised within
the period of 60 days ending on the day before the tenth anniversary of the Date of Grant of the Option. For the avoidance of doubt,
nothing in these Rules shall require the Company to facilitate the disposal in any manner whatsoever of any Shares acquired on
any such exercise pursuant to this Rule 9.5.


 


	10.	Exercise of Options



 


	10.1	Procedure on exercise



 


An Option shall be exercisable,
in whole or in part, by the delivery to the secretary of the Company of the following:


 


(a)         
an Option Agreement covering all of the Shares over which the Option is then to be exercised;


 


(b)         
the Notice of Exercise in the prescribed form duly completed and signed by the Option Holder (or by his duly authorised
agent);


 


(c)          
a Section 431 Election (or a similar election should the Directors so require);


 


(d)         
payment (or such arrangements for the making of such a payment as the Directors shall permit) of a sum equal to the
aggregate Option Price for the number of Shares over which the Option is to be exercised;


 


(e)         
payment (or such arrangements for the making of such a payment as the Directors shall permit) of any Tax Liability
and Employer’s NICs in accordance with Rule 10.4; and


 






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(f)           if
and to the extent that existing shareholders in the Company are subject to Restrictions on the exercise of any rights attaching
to their Shares in the Company as embodied in any shareholders’ agreement or other such document, is accompanied by a deed
of adherence in a form acceptable to the Company and executed by the Option Holder whereby the Option Holder agrees to be bound
by the terms of such shareholders’ agreement or other such document.


 


	10.2	Issue or transfer of Shares



 


The Company shall issue or procure
the transfer of Shares to be allotted or transferred pursuant to the exercise of an Option to the Option Holder such number of
Shares within 30 days following the effective date of exercise of the Option.


 


	10.3	Shares issued pursuant to the Scheme will rank pari passu in all respects with the Shares then
already in issue except that they and any Shares transferred pursuant to the Scheme will not rank for any dividend or other distribution
of the Company paid or made by reference to a record date falling prior to the date of receipt of the Notice of Exercise of the
Option pursuant to Rule 10.1.



 


	10.4	Deductions



 


(a)         Where
in relation to Options, the Company or any Group Company (the “Relevant Company”) is liable, or is in accordance
with current practice believed to be liable under any statute or regulation or otherwise, to account to any revenue or other authority
for sums in respect of a Tax Liability in relation to the Option, the Option Holder shall indemnify and shall keep indemnified
the Relevant Company for the Tax Liability and the Option Holder shall pay the Relevant Company a sum equal to the Tax Liability
immediately upon written notice of the quantum of the said liability.


 


(b)         Notwithstanding
the above, the Company may impose such conditions upon the exercise of the Options as are necessary to ensure that the Relevant
Company is able to meet any or all of such liabilities, including, without limitation, a condition that no exercise may take place
unless the Option Holder has provided the Relevant Company with cash funds sufficient to meet such Tax Liability, or has entered
into arrangements acceptable to the Relevant Company to secure that such cash funds are available, or to allow the Relevant Company
to deduct the amount of such Tax Liability from any cash amounts (including salary and bonuses) which may become payable to the
Option Holder by any Group Company.


 


(c)          
The Company may require the Option Holder as a condition of the exercise of any Option that the Option Holder shall:


 


(i)           
agree to reimburse the Relevant Company for any Employer’s NICs arising on the exercise of an Option; or


 


(ii)           enter
into an election with the Relevant Company to assume the liability for any Employer’s NICs, payable on the exercise of the
Option, including an election under paragraph 3B of Schedule 1 to the Social Security Contributions and Benefits Act 1992; OR


 






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(iii)          agree
to pay the employer’s social security contributions, to the extent permitted by law, in any other jurisdiction.


 


(d)         
If the Option Holder shall fail to:


 


(i)           
make payment to the Relevant Company immediately upon receipt of a written notice in accordance with Rule 10.4(a);
or


 


(ii)          
reimburse the Relevant Company in accordance with an agreement or election in whole or in part for any liability
to Employer’s NIC or employer’s social security contributions pursuant to Rule 10.4(a);


 


then the Company shall be authorised
by the Option Holder to reduce the number of Shares otherwise deliverable to the Option Holder upon the exercise of an Option as
may be sufficient to produce a sum which (after allowance for the costs and expenses of such a sale) may discharge (and shall be
applied in discharge of) the Option Holder’s liability to the Relevant Company under Rule 10.4(a) or any agreement or election
pursuant to Rule 10.4(a) and the Company may exercise all such powers and may appoint any of its officers to sign all such documents
in the name of the Option Holder and as his act and deed as may be necessary for this purpose.


 


(e)         
If the Option Holder shall fail to make payment to the Relevant Company immediately upon receipt of a written notice
in accordance with Rule 10.4(a) then the Option Holder shall be liable to make good any amount outstanding on demand.


 


	11.	Lapse of Options



 


	11.1	General



 


An Option shall immediately cease
to be exercisable and shall lapse on the earliest of:


 


(a)         
the tenth anniversary of the Date of Grant;


 


(b)         
the date upon which the Option Holder ceases to hold employment or office within the Group if the Option Holder is
a Bad Leaver, or in the case of termination for Cause, on the date of occurrence of such Cause;


 


(c)          the
expiry of the periods in Rule 9.3, except that if the Option Holder dies during the exercise period specified in Rule 9.3 or before
exercise in accordance with Rule 12 an Option shall not lapse by reason of this Rule 11.1 until the first anniversary of the Option
Holder’s death, if later;


 


(d)          the
first anniversary of the Option Holder’s death;


 


(e)         
subject to Rule 13.1, the expiry of any of the periods referred to in Rule 12;


 


(f)           the
date on which it is purported to be transferred or assigned (other than by reason of death in accordance with Rule 9.4), mortgaged,
charged or otherwise disposed of by the Option Holder;


 






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(g)          the
successful presentation of any petition to any court of competent jurisdiction by which an order is sought for the bankruptcy
of the Option Holder;


 


(h)          upon
the Option Holder making an application for an interim order or any proposal for a voluntary arrangement within Part VIII of the
Insolvency Act 1986;


 


(i)           upon
the Option Holder proposing any form of compromise with his creditors or any class of creditors; and


 


(j)           the date on which the Option Holder is deprived (otherwise than on death) of the legal or beneficial ownership of the Option by
operation of law or by the Option Holder doing or omitting to do anything which causes him to be so deprived.


 


	12.	Takeover, Reconstruction, Liquidation and Sale of the Business



 


	12.1	Offer



 


If any person obtains Control
of the Company as a result of:


 


(a)           making
an offer to acquire the whole of the issued share capital of the Company which is made on a condition such that, if it is satisfied,
the person making the offer will have Control of the Company; or


 


(b)         
making a general offer to acquire all the shares in the Company which are of the same class as those to which the
Option relates;


 


(c)          negotiating a share sale and purchase agreement with the shareholders of the Company which contemplates that the
person will acquire the whole of the issued share capital of the Company on completion;


 


(an “Offer”),
an Option may be exercised to the extent set out in Rule 12.2, in accordance with the provisions of Rule 12.3.


 


	12.2	An Option may be exercised under Rule 12.1 (and, for the avoidance of doubt) under Rules 12.5,
12.6, 12.7 and 12.9) to the extent Vested as at the date of such Offer or other event under this Rule 12, and the Directors (acting
with Investor Director Consent) may, at their discretion, allow an Option Holder to exercise any Unvested Option(s).



 


	12.3	Notification of Offer



 


(a)          If
the Directors (acting on behalf of the Company) notify the Option Holder in writing as soon as practicable of the fact that
such person has made an Offer under Rule 12.1 (the “Notification”) which may result in that person
obtaining Control of the Company (and for the purposes of this Rule 12.3 the time that Control is obtained shall be referred
to as the “Unconditional Time”), the Option Holder may deliver his Notice of Exercise and the aggregate
Option Price (under the procedure in Rule 10.1) at any time in the period commencing on the Option Holder’s receipt of
the Notification and ending immediately before the Unconditional Time. Any Notice of Exercise delivered in accordance with
this Rule 12.3 shall be exercised immediately before the Unconditional Time. The Option shall not be exercisable following
the Unconditional Time but may still be released under Rule 13 within the period of six months following the change of
Control of the Company and on the expiry of the said six month period the Option shall lapse; or


 






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(b)         
In the event that no Notification is made (as permitted by Rule 12.3(a), the Option may be exercised within 90 days
(or within any longer time period as referred to in section 532(1)(b) ITEPA) of such change of Control. The Option shall not be
exercisable after 90 days (or within any longer time period as referred to in section 532(1)(b) ITEPA) from the date of the change
of Control but may still be released under Rule 13 within the period of six months following the change of Control of the Company
and on the expiry of the said six month period the Option shall lapse.


 


(c)          
For the avoidance of doubt, where a Notification is made in Rule 12.3(a) and the Directors become aware that the
proposed Offer will not proceed, the Directors shall return the Notice of Exercise and the aggregate Option Price to the Option
Holder, and no exercise of the Option shall be treated as having occurred in relation to such offer under Rule 12.1.


 


	12.4	Control



 


For the purposes of Rule 12.1
a person shall be deemed to have obtained Control of the Company if he and others acting in concert with him have together obtained
Control of it.


 


	12.5	Scheme of arrangement



 


If any person obtains Control
of the Company in pursuance of a compromise or arrangement sanctioned by the court under section 899 of the Companies Act (a “Compromise”),
an Option may be exercised to the extent set out in Rule 12.2 within 90 days (or within any longer time period as referred to in
section 532(1)(b) ITEPA) of the court sanctioning the Compromise. An Option shall not be exercisable after the said 90 days (or
longer time period as referred to in section 532(1)(b) ITEPA) but may still be released under Rule 13 within the period of six
months following the court sanction of the Compromise and, on the expiry of the said six month period, the Option shall lapse.


 


	12.6	Chapter 3, Part 28 of the Companies Act - Squeeze out provisions



 


If any person becomes bound or
entitled to acquire shares under Chapter 3, Part 28 of the Companies Act, an Option may be exercised to the extent set out in Rule
12.2 at any time when that person remains so bound or entitled.


 


	12.7	Liquidation



 


If a general meeting of the
Company is called at which it is proposed to pass a resolution for the members’ voluntary winding up of the Company,
the Company shall notify the Option Holder as soon as practicable of this fact. An Option may be exercised to the extent set
out in Rule 12.2 during the period of such notice (such exercise being conditional on such resolution being passed and taking
effect immediately thereafter) and such portion of the Option not otherwise exercised before such resolution has been passed
shall thereupon lapse. Where the Option Holder has exercised the Option pursuant to this Rule 12.7 and the resolution
referred to above has been passed then (subject to the consent of the Company’s liquidator where such is required by
section 88 of the Insolvency Act 1986) the exercise of the Option shall take effect immediately and the Option Holder shall
be entitled to share in the assets of the Company with the existing shareholders in the same manner as the Option Holder
would have been entitled had the Option Holder been the registered owner of the relevant Shares before the resolution was
passed. For the avoidance of doubt, this Rule 12.7 will not apply to a creditors’ voluntary winding up.


 






    16


     


    

 


	12.8	Reorganisation



 


An Option may not be exercised
under Rule 12.1 if the Offer is part of a reorganisation so that the shareholders of the Acquiring Company hold their shares in
the Acquiring Company in the same proportions as they held their shares in the Company.


 


	12.9	Sale of Business



 


An Option may be exercised to
the extent set out in Rule 12.2 within 90 days (or within any longer time period as referred to in section 532(1)(b) ITEPA) of
a Sale of the Business and the Company shall notify the Option Holder as soon as practicable of this fact. The Directors (acting
with the Investor Director Consent) may permit exercise of an Option at their discretion in the event of a sale of a material part
of the business (which does not constitute a Sale of the Business).


 


	12.10	Admission to Listing



 


If the Company’s shares
are admitted to listing on the Main Market of the London Stock Exchange, AIM or to or any other securities exchange, an Option
may be exercised to the extent Vested during such periods as the Directors shall determine in their discretion, and the Directors
(acting with Investor Director Consent) may, at their discretion, allow an Option Holder to exercise any Unvested part of an Option
during such periods.


 


	13.	Replacement Options



 


	13.1	Grant of Replacement Options



 


If any company (the “Acquiring
Company”):


 


(a)         
obtains Control of the Company as a result of making an Offer in accordance with Rule 12.1(a) or 12.1(b); or


 


(b)         
obtains Control of the Company as a result of a Compromise in accordance with Rule 12.5; or


 


(c)          
becomes bound or entitled to acquire the Shares under Chapter 3, Part 28 of the Companies Act in accordance with
Rule 12.6, or


 


(d)         
obtains all the Shares as a result of a Qualifying Exchange within Rule 13.3,


 


an Option Holder may at any time
within the period set out in Rule 13.2, by agreement with the Acquiring Company, release any Option which has not lapsed (the “Old
Option”) in consideration of the grant to him of an Option (the “New Option”) which is equivalent
to the Old Option but relates to shares in the Acquiring Company and qualifies as a Replacement Option as set out in Rules 13.4
and 13.5.


 






    17


     


    

 


	13.2	Period within which Replacement Option to be granted



 


The New Option must be granted
within the following periods:


 


(a)         
if the change of Control is by reason of a general offer in accordance with Rule 12.1, the period of six months beginning
with the time when the person making the offer has obtained control of the Company and any condition subject to which the offer
is made is satisfied;


 


(b)         
if the change of Control is by reason of a Compromise (in accordance with Rule 12.5) or a Qualifying Exchange the
period of six months beginning with the time when the Acquiring Company obtains Control of the Company whose shares are subject
to the Old Option;


 


(c)          
if the change of Control occurs under Chapter 3, Part 28 of the Companies Act, the period during which the Acquiring
Company remains bound or entitled in accordance with those procedures.


 


	13.3	Exchange of Shares



 


(a)         
An exchange of shares will be treated as a Qualifying Exchange where arrangements are made in accordance with which
a company (the “New Company”) acquires all the shares (the “Old Shares”) in another company
(the “Old Company”) and the following conditions are met:


 


(i)           
that the consideration for the Old Shares consists wholly of the issue of shares (the “New Shares”)
in the New Company;


 


(ii)          
that New Shares are issued in consideration of Old Shares only at times when there are no issued shares in the New
Company other than:


 


		(A)	subscriber shares, and



 


		(B)	New Shares previously issued in consideration of Old Shares;



 


(iii)         
that the consideration for New Shares of each description consists wholly of Old Shares of the corresponding description;


 


(iv)         
that New Shares of each description are issued to the holders of Old Shares of the corresponding description in respect
of, and in proportion to, their holdings; and


 


(v)          
that by virtue of section 127 of the Taxation of Chargeable Gains Act 1992 as applied by section 135(3) of that Act,
the exchange of shares is not treated as involving a disposal of the Old Shares or an acquisition of the New Shares.


 


(b)         
For the purposes of this Rule Old Shares and New Shares are of a corresponding description if, on the assumption
that they were shares in the same company, they would be of the same class and carry the same rights, and references to “shares”,
except in the expression “subscriber shares”, includes securities.


 






    18


     


    

 


	13.4	Qualifying requirements for Replacement Option



 


Subject to Rule 13.5, a New Option
qualifies as a Replacement Option only if:


 


(a)         
the New Option is granted to the Option Holder by reason of his employment:


 


(i)           
with the Acquiring Company, or


 


(ii)          
if that company is a Parent Company, with that company or another Group Company;


 


(b)         
at the time of the release of rights under the Old Option, the purpose for granting the New Option is for commercial
reasons in order to recruit or retain an Eligible Employee, and not as part of a scheme or arrangement the main purpose, or one
of the main purposes, of which is the avoidance of tax;


 


(c)          
at that time,


 


(i)           
the Independence Requirement and the Trading Activities Requirement are met in relation to the Acquiring Company;


 


(ii)          
the individual to whom the New Option is granted is an Eligible Employee in relation to the Acquiring Company; and


 


(iii)         
the New Option would satisfy the requirements of being an EMI Option set out in Part V of Schedule 5;


 


(d)         
the total Market Value, immediately before the release, of the Shares which were subject to the Old Option is equal
to the total Market Value, immediately after the grant, of the Shares in respect of which the New Option is granted; and


 


(e)         
the total amount payable by the employee for the acquisition of shares in pursuance of the New Option is equal to
the total amount that would have been payable for the acquisition of shares in pursuance of the Old Option.


 


	13.5	Provided that a Replacement Option for an Unapproved Option shall not have to satisfy the requirements
in Rule 13.4(b) and Rule 13.4(c).



 


	13.6	Where, in accordance with this Rule 13, an Option is released and a New Option granted, the New
Option shall not be exercisable in accordance with Rule 12 by virtue of the event which gave rise to the New Option being granted.



 


	14.	Loss of Office or Employment



 


	14.1	The grant of an Option does not form part of the Option Holder’s entitlement to remuneration
or benefits pursuant to his contract of employment nor does the existence of a contract of employment between an Eligible Employee
and any company give such Eligible Employee any right or entitlement to have an Option granted to him in respect of any number
of Shares or any expectation that an Option might be granted to him whether subject to any conditions or at all and the grant of
an Option shall not give him any entitlement or expectation that further Options will be granted.



 






    19


     


    

 


	14.2	The rights and obligations of an Option Holder under the terms and conditions of his office or
employment shall not be affected by his participation under the Rules or any right he may have to participate.



 


	14.3	An individual who participates under the Rules waives all and any rights to compensation or damages
in consequence of the termination of his office or employment with any company for any reason whatsoever, whether lawful or not,
in so far as those rights arise, or may arise, from his ceasing to have rights under or be entitled to exercise any Option under
the Rules as a result of such termination or from the loss or diminution of value of such rights or entitlements. If necessary,
the Option Holder’s terms of employment shall be varied accordingly.



 


	15.	Adjustments



 


	15.1	General rule



 


The number of Shares over which
an Option is granted and the Option Price thereof shall be adjusted in such manner as the Directors shall reasonably determine
following any capitalisation issue, rights issue, subdivision, consolidation or reduction of share capital of the Company or any
other variation of share capital to the intent that (as nearly as may be) the total Option Price multiplied by the number of Shares
that is payable in respect of an Option shall remain unchanged.


 


	15.2	Reduction of Option Price to below nominal value



 


Subject to Rule 15.3 below, an
adjustment may be made under Rule 15.1 above which would have the effect of reducing the Option Price of unissued shares to less
than the nominal value of a Share, but only if, and to the extent that, the Directors shall be authorised to capitalise from the
reserves of the Company a sum equal to the amount by which the aggregate nominal value of the Shares in respect of which the Option
is exercisable exceeds the aggregate adjusted Option Price, so that on exercise of any Option in respect of which the Option Price
has been reduced, the Directors shall capitalise and apply such sum (if any) as is necessary to pay up the amount by which the
aggregate nominal value of the Shares in respect of which the Option is exercised exceeds the aggregate Option Price for such Shares.


 


	15.3	Option over issued and unissued Shares



 


Where an Option subsists over
both issued and unissued Shares, an adjustment permitted by Rule 15.2 above, may only be made if the reduction of the Option Price
of both issued and unissued Shares can be made to the same extent.


 


	15.4	Administrative steps



 


The Directors shall notify Option
Holders of any adjustment made under this Rule 15 as soon as reasonably practicable and may take such steps and the Company shall
execute such documents as it considers necessary to give effect to such adjustment. Furthermore, and without limitation to the
generality of the foregoing, the Directors may call in, cancel, endorse, issue or reissue any Option Agreement subsequent upon
such adjustment.


 






    20


     


    

 



 


		16.	General



 


		16.1	Amendments



 


		(a)	Subject to Rules 16.1(b) to 16.1(d), the Directors shall
have the discretion to:



 


(i)           
amend or add to the Rules; and


 


(ii)          
impose additional conditions or requirements on the Options or on the terms on which Shares are acquired.


 


		(b)	No amendments may be made to the Rules which would have
the effect of causing EMI Options to cease to be EMI Options.



 


		(c)	The Directors may at any time make such alterations (including
additions) to the Rules as are necessary to secure that the Rules as applicable to EMI Options are in accordance with Schedule
5 and continue to be in accordance with Schedule 5.



 


		(d)	No amendment or addition shall be made to the Rules which
would abrogate or adversely affect the subsisting rights of Option Holders unless:



 


(i)          
where the rights are enjoyed by a single Option Holder and are not enjoyed by any other Option Holder or class of
Option Holders, it is made with the written consent of that Option Holder; or


 


(ii)          
where the rights are enjoyed by all Option Holders or any class of Option Holders then:


 


		(A)	with the consent in writing of such number of Option Holders or class of Option Holders (as the
case may be) as hold Options under the Scheme to acquire 75 per cent (75%) of the Shares which would be issued or transferred if
all Options granted and subsisting under the Scheme were exercised; or



 


		(B)	by a resolution at a meeting of Option Holders or class of Option Holders passed by not less than
75 per cent (75%) of the Option Holders who attend and vote either in person or by proxy; and for the purpose of this Rule 16.1(d)
the Option Holders or any class of Option Holders shall be treated as the holders of a separate class of share capital and the
provisions of the Articles of Association of the Company relating to class meetings shall apply mutatis mutandis.



 


		16.2	Termination



 


The Scheme shall terminate upon
the tenth anniversary of the Adoption Date or at any earlier time by the passing of a resolution by the Directors. Termination
shall be without prejudice to the subsisting rights of Option Holders.


 






    21 


     


    

 


		16.3	Conflict with Schedule 5



 


If there is any conflict between
the provisions of the Rules as they apply to EMI Options and Schedule 5, Schedule 5 shall take precedence in respect of EMI Options.


 


		16.4	Notices and documents



 


		(a)	Option Holders not otherwise entitled thereto may at
the discretion of the Company be sent copies of notices and other documents sent by the Company to its ordinary shareholders generally.



 


		(b)	Written notice of any amendment made in accordance with
this Rule 16 shall be given to those Option Holders affected by such amendment.



 


		(c)	Any notice or other document required to be given hereunder
to any Option Holder shall be delivered to him by one of the following methods:



 


		(i)	by hand to his home address according to the records
of the Company or such other address as may appear to the Directors to be appropriate. Such notices shall be deemed to have been
given on the date of delivery;



 


		(ii)	by first class pre-paid post to him at his home address
according to the records of the Company or such other address as may appear to the Directors to be appropriate. Such notices shall
be deemed to have been given on the second business day following the date of posting;



 


		(iii)	by email to the Option Holder’s work email address
(or personal email address, if known to the Company). Such notices shall be deemed to have been given on the date the email is
sent; or



 


		(iv)	by fax, to a fax number given to the Company by the Option
Holder. Such notices shall be deemed to have been given on the date the email is sent.



 


		(d)	Any notice or other document required to be given to
the Directors shall be delivered to the Directors or sent by first class pre-paid post to the Directors at the Company’s
registered office or such other address as may be determined by the Directors to be appropriate. Such notices shall be deemed
to have been given on the second business day following the date of posting.



 


		16.5	Disputes



 


The decision of the Directors
in any dispute or question relating to any Option shall be final and conclusive subject to the terms of this Scheme.


 


		16.6	Governing Law



 


The Rules shall be governed by
and construed in accordance with English law.


 


		16.7	Contracts (Rights of Third Parties) Act 1999



 


Except as expressly
provided by the Company, a person who is not the Option Holder or a company who is not a member of the Group has no right
under the Contracts (Rights of Third Parties) Act 1999 to rely upon or enforce any provisions of this Scheme, but this does
not affect any right or remedy of a third party which exists or is available apart from that Act. The Option Holder may not
declare himself a trustee of his rights under this Scheme for the benefit of any third parties.


 






    22 


     


    

 


		16.8	Data Protection



 


The Company and the Employer
Company (if different) from time to time will collect, hold and process the Option Holder’s personal information for the
purposes of the administration of this Option. The Company will not use such personal information for any purpose other than the
administration of the Option, unless the Option Holder’s consent to that use is obtained.


 


		17.	Overseas Employees



 


Notwithstanding any other provision
of the Scheme the Directors may amend or add to the provisions of the Scheme and the terms of Option Agreements they consider necessary
or desirable to take account of, or to mitigate, or to comply with relevant overseas taxation, securities or exchange control laws,
provided that the terms of Options granted to such Employees are not more favourable overall than the terms of Awards granted to
other Employees.


 


		18.	Supplementary Provisions



 


The Group shall not be liable
to the Option Holder for any tax or additional tax or national insurance payable by the Option Holder upon the exercise of an Option
or upon the subsequent disposal of any Shares acquired upon exercise of the Option being tax or national insurance payable because
of a failure to qualify for relief under sections 529 to 532 of ITEPA in consequence of anything done by the Group.


 






    23 


     


    

 


SCHEDULE
1


 


OPTION AGREEMENT


 


THIS DOCUMENT
IS IMPORTANT AND SHOULD BE KEPT IN A SAFE PLACE


 


THIS OPTION AGREEMENT is made the
[•] day of [•] 20


 


BETWEEN


 


		(1)	VACCITECH LIMITED (registered no 09973585) whose registered office is at Magdalen Centre,
1 Robert Robinson Avenue, The Oxford Science Park, Oxford, Oxfordshire OX4 4GA (the “Company”); and



 


		(2)	[Name] of [Address] (the “Option
Holder”)



 


SUPPLEMENTAL to the rules of the
Vaccitech Limited EMI Share Option Scheme (the “Scheme”). Any words or expressions used in this option agreement
and defined by the Scheme shall bear the same meaning in this agreement.


 


INTRODUCTION:


 


(A)       The Company intends
to grant an Option to the Option Holder.


 


(B)       The Option is intended
to be an [EMI option/unapproved option].


 


(C)       [The Option is
granted under Schedule 5 ITEPA 2003.]


 


AGREED TERMS


 


		1	Grant



 


The Company GRANTS an
[EMI option/unapproved option] to the Option Holder and the Option Holder AGREES to be bound in all respects by the provisions
of the Scheme and ACCEPTS the grant on the terms set out in their agreement.


 


		2	Terms of the Scheme



 


		2.1	Under the terms of the Scheme the Option Holder may acquire the number of ordinary shares (the
“Shares”) in the Company stated in 7.1(a) at the Option price per Share set out in 7.1(b).



 


		2.2	The Option is granted and exercisable subject to the terms and conditions set out in the Scheme
and in this Option Agreement.



 


		3	Articles



 


Any Shares allotted or transferred
pursuant to the exercise of the Option are subject to the articles of association of the Company (as amended from time to time)
and to any necessary consents of any governmental or other authorities under any enactments from time to time in force.


 






    24 


     


    

 


		4	Restrictions



 


The Shares allotted or transferred
pursuant to the exercise of the Option are subject to restrictions in the Articles of the Company and in the subscription and shareholders’
agreement which are summarised at Appendix 2 to this Option Agreement.


 


		5	Non transferable



 


The Option is personal to the
Option Holder and is not transferable, assignable or chargeable.


 


		6	Exercise



 


The Option shall not be exercisable
on or after the 10th Anniversary of the Date of Grant.


 


		7	Grant



 


		7.1	The details of the grant are as follows; namely



 


		(a)	Number of Shares subject to the Option	[•].



 


		(b)	Option Price per Share	[•].



 


		(c)	Date of Grant	[•].



 


		(d)	Vesting Commencement Date	[•].



 


		7.2	The Option Holder irrevocably agrees to reimburse the Relevant Company for any Employer’s
NICs arising on the exercise of an Option; or agrees to enter into an election with the Relevant Company to assume the liability
for any Employer’s NICs, payable on the exercise of the Option, including an election under paragraph 3B of Schedule 1 to
the Social Security Contributions and Benefits Act 1992.



 


		7.3	The exercise of the Option shall be conditional upon the Option Holder making good any Tax Liability
in relation to the Option, or entering into arrangements acceptable to the Company in respect of such Tax Liability, in accordance
with rule 10.4 of the Scheme.



 


		7.4	The Option shall Vest in accordance with the Vesting Schedule at Appendix 1 to this Option Agreement.



 


		8	Working Time Declaration



 


The Option Holder hereby declares,
pursuant to the requirement set out in paragraph 44(5)(c) of Schedule 5, that he works for the Company or for a subsidiary of the
Company for at least 25 hours a week or, if less, at least 75% of his working time, and therefore satisfies the Committed Time
requirement in paragraph 26 of Schedule 5.


 






    25 


     


    

 


This option agreement has been executed
as a deed and unconditionally delivered on the date first above written.


 


	SIGNED as a DEED	)
	by VACCITECH LIMITED	)
	acting by a director	)
	 
	 	 	Director
	 
	Signature of Witness:
	 
	Name of Witness:
	 
	Address:
	 
	Occupation:
	 
	SIGNED as a DEED	)
	by [Option Holder]	)
	 
	Signature of Witness:
	 
	Name of Witness:
	 
	Address:
	 
	Occupation:




 


NOTE: The Company shall retain the original
signed and dated option agreement and give a copy to the Option Holder within 7 days to satisfy paragraph 44(5A) of Schedule 5
or two copies of the option agreement shall be signed, one for the Company and one for the Option Holder.


 






    26 


     


    

 


APPENDIX 1


 


Vesting Schedule


 


The Vesting Schedule is as follows that
the Shares shall Vest in four equal annual instalments from the Vesting Commencement Date, so that the Option shall be fully Vested
on the fourth anniversary of the Vesting Commencement Date. The number of Shares that Vest shall be rounded up to the nearest whole
number of Shares.


 






    27 


     


    

 


APPENDIX 2


 


Restrictions Summary


 


The following is a summary of the restrictions
on the Shares, so that the Option Holder has an understanding of the restrictions prevailing at the time of the grant of the Option.


 


Restrictions in Articles of Association


 


The references are to the articles of association
of the Company adopted on 10 November 2017 (the “Articles”), which can be obtained from [Graham Griffiths],
and any defined terms are defined in the Articles. For full details, the Option Holder should refer to the Articles.


 


Liquidation preference (Articles 5 and
6)


 


On a distribution of assets, distributions
will only be made to holders of Ordinary Shares, pro rata to the number of Ordinary Shares held, of the surplus of assets (if any)
after an amount per share held equal to the Preference Amount has been distributed to Series A Shareholders, and a total of £1.00
has been distributed to the holders of any Deferred Shares. On a Share Sale, the proceeds of sale are dealt with in a similar way.


 


Down round protection (Article 10)


 


The Series A shares have anti-dilution
protection which is not available to the Ordinary Shares.


 


Pre-emption (Article 13)


 


The Ordinary Shares are subject to pre-emption
rights, but these do not apply to Ordinary Shares acquired on the exercise of options.


 


Restrictions on transfers of Shares
(Article 14)


 


A Transfer Notice will be deemed to be
served in respect of all a Shareholder’s Shares if that Shareholder transfers or purports to transfer a Share other than
in accordance with the Articles.


 


Transfers to the following may be refused
by the Directors:


 


		·	Bankrupts, minors, persons of unsound mind;



 


		·	Employees who have not entered into a joint s.431 ITEPA election;



 


		·	More than four transferees



 


The Directors may refuse a transfer:


 


		·	of a Share which is not fully paid to a person of whom the Directors do not approve, or on which
Share the Company has a Lien;



 


		·	which is not lodged at the registered office;



 


		·	which is not accompanied by a certificate or acceptable indemnity;



 






    28 


     


    

 


		·	in respect of more than one class of Shares; and



 


		·	In certain other circumstances provided by the articles.



 


The Directors may require the transferee
to agree to be bound by the Shareholders’ Agreement as a condition of transfer.


 


If a disposal of Shares is made in breach
of the Articles, or interested parties fail to provide information to enable the Directors to determine whether this is the case,
the relevant shares will cease to carry voting rights or entitlement to dividends or other distributions, and the holder may be
required to transfer some or all of their Shares at a price required by the Directors.


 


Restrictions on Permitted Transfers
(Article 15)


 


No transfer of Shares may be made to Trustees
unless the Board is satisfied as to certain conditions.


 


The following must transfer their Shares
to the Original Shareholder or a Permitted Transferee of the Original Shareholder, or give a Transfer Notice to the Company:


 


		·	Permitted Transferees by virtue of marriage or Civil Partnership who cease to be a spouse or Civil
Partner of the Original Shareholder;



 


		·	The personal representatives of a deceased Permitted Transferee.



 


Pre-emption rights on transfer of Shares
(Article 16)


 


A Seller must give other Shareholders the
opportunity to purchase Sale Shares before they are offered to a proposed third party transferee. The purchase price will be the
Fair Value, determined by an expert as per Article 17, if a value cannot be agreed. Only those Sale Shares not purchased under
this pre-emption process may be sold to a third party, which must not be a competitor - and this sale must be bona fide and is
subject to adequate information being provided to the Board to determine this.


 


Compulsory transfers (Article 18)


 


A Transfer Notice will be deemed to be
given by:


 


		·	Persons entitled to a Share in consequence of a Shareholder’s bankruptcy; and



 


		·	Personal representatives of a deceased Shareholder, following the first anniversary of that Shareholder’s
death.



 


Departing employees - Bad Leaver provision
(Article 19)


 


All Employee Shares held by a Bad Leaver
will convert into worthless Deferred Shares on their Effective Termination Date. There are provisions for Good Leavers, but these
do not apply to Ordinary Shares acquired on the exercise of an option.


 






    29 


     


    

 


Mandatory Offer on a Change of Control
(Article 20)


 


A Proposed Seller may only make a Proposed
Transfer (to a Proposed Purchaser who would acquire a Controlling Interest in the Company) if the Proposed Purchaser makes an offer
to the other Shareholders to acquire all of the Equity Shares at at least the Specified Price.


 


Co-Sale right (Article 21)


 


Any Selling Employee must give to each
Equity Holder notice of a proposed sale which will give Equity Holders an opportunity to tag along on a proposed sale (subject
to certain conditions).


 


Drag-along provisions (Article 22)


 


If the holders of at least 75% of the Equity
Shares wish to transfer all their interest in Shares to a Proposed Purchaser, they have the option to compel the remaining shareholders
to sell their shares to the Drag Purchaser, with the consideration being distributed pro rata in accordance with Articles 5 and
6.


 


Restrictions in Subscription and Shareholders’
Agreement


 


The references are to the Subscription
and Shareholders’ Agreement between the Investors, the Founders, the Manager, the University, Oxford University Innovation
Limited and the Company dated 10 November 2017, as varied by the Variation, Subscription and Adherence Agreement between the Investors,
the Founders, the Manager, the University, OUI, the Company and SCC Venture VI Holdco, Ltd dated 10 January 2018 (the “Subscription
and Shareholders’ Agreement”), which can be obtained from Graham Griffiths, and any defined terms are defined in
the Subscription and Shareholders’ Agreement.


 


Restrictions on further issue and transfer


 


No transfer of Shares may take place without
the transferee becoming bound by a Deed of Adherence, unless the Board (with Investor Majority Consent) approve otherwise.


 






    30 


     


    

 



 


SCHEDULE
2


 


NOTICE OF EXERCISE


 


TO:         The Secretary, Vaccitech Limited


 


I/We, being the holder or the Personal
Representative(s) of the holder,* of an option granted over Vaccitech Limited shares (the “Option”):


 


	1.1	hereby exercise the Option to acquire              ordinary shares in Vaccitech Limited (the “Shares”)
at a price of £[•] per ordinary share, subject to the provisions contained in an Option Agreement dated [•] (the
“Agreement”) made pursuant to the Vaccitech Limited EMI Share Option Scheme and made between Vaccitech Limited
and [•];



 


	1.2	enclose a cheque for the total price of the Shares (£          ) in favour of Vaccitech
Limited (the “Company”) and crossed “a/c payee”, or such other documentation in respect of bridging
finance or undertaking to procure payment as may be agreed by the Directors;



 


	1.3	authorise and request you to enter my/our name(s) in the Company’s Register of Members as
the holder(s) of the Shares, subject to the Company’s articles of association;



 


	1.4	hereby covenant to pay the Company the amount of any Tax Liability** which may arise as a consequence
of or in connection with this exercise of the Option (and, for the purposes of this Notice of Exercise, the expression “Tax
Liability” has the same meaning as it has in the Agreement;



 


	1.5	in order to give effect to this covenant, I/we hereby authorise and appoint the Company as my/our
attorney in my/our name(s) and on my/our behalf:



 


		(a)	to sell such number (but no more) of the Shares registered in my/our name(s) as will enable the
Company (after payment of all necessary selling expenses and commissions) to recover and retain for itself from the sale proceeds
an amount equal to such Tax Liability and then account to me/us for any cash balance remaining, provided that the Company may sell
that number of shares at such price or prices as it shall, in its absolute discretion, consider fair and reasonable, and



 


		(b)	generally to sign any stock transfer form or other document or documents which may be required
and to do any other thing which the Company shall consider necessary or expedient for carrying out the acts hereby authorised in
the same manner and as fully in all respects as I/we could have done personally and I/we hereby undertake to ratify everything
which the Company shall do or purport to do by virtue of this power of attorney; and



 


	1.6	request you to send a share certificate in respect of the Shares not sold pursuant to the authority
given above (and, if appropriate, a balance option certificate) to me/us at the address given below.



 






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SIGNED and DELIVERED as a DEED BY


 


	Name 	   	 	 	Address	   	 
	 	   	 	 	 	 	 
	Signature	   	 	 	 	   	 
	 	   	 	 	 	 	 
	Date	   	 	 	 	 	 




 


In the presence of:


 


	Witness’ Name	   	 	 	 Address	   	 
	 	 	 
	Witness’ Signature	   	 	 	 	   	 




 


* Personal Representatives should enclose
an Office Copy of the relevant Grant of Probate or Letters of Administration.


 


** Persons exercising the option should
consult with the Company as to whether any Tax Liability is anticipated, however the Company does not undertake to advise you on
the tax consequences of exercising your Option. If you are unsure of the tax liabilities which may arise you should take appropriate
professional advice before exercising your Option.


 






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SCHEDULE
3


 


S.431 ELECTION


 


Joint Election under s.431 ITEPA 2003
for full or partial disapplication of Chapter 2

Income Tax (Earnings and Pensions) Act 2003


 


Employment-related securities acquired
on exercise of qualifying options exercised

before the tenth anniversary of the date of grant.


 


One Part Election 


 


	BETWEEN the Employee	[•]
	 	 
	whose National Insurance Number is 	[•]
	 	 
	and	 
	 	 
	the Company (which is the Employee’s employer) Vaccitech
    Limited	 
	 	 
	of Company Registration Number 	09973585




 


Purpose of Election


 


This joint election is made pursuant to
section 431(1) Income Tax (Earnings and Pensions) Act 2003 (ITEPA) and applies where employment-related securities, which are restricted
securities by reason of section 423 ITEPA, are acquired.


 


The effect of an election under section
431(1) is that, for the relevant Income Tax and NIC purposes, the employment-related securities and their market value will be
treated as if they were not restricted securities and that sections 425 to 430 ITEPA do not apply.


 


	Should the value of the securities fall following the acquisition, it is possible that Income Tax/NIC that would have arisen because of any future chargeable event (in the absence of an election) would have been less than the Income Tax/NIC due by reason of this election. Should this be the case, there is no Income Tax/NIC relief available under Part 7 of ITEPA 2003; nor is it available if the securities acquired are subsequently transferred, forfeited or revert to the original owner.




 


Application


 


This joint election is made not later than
14 days after the date of acquisition of the securities by the employee and applies to:


 


	Number of securities	 	 
	 	 	 
	Description of securities	Ordinary shares in the capital of Vaccitech Limited
	 	 
	Name of issuer of securities	Vaccitech Limited
	 	 
	Acquired by the Employee on	 	 




 






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Extent of Application


 


This election disapplies s.431(1) ITEPA:
All restrictions attaching to the securities.


 


Declaration


 


This election will become irrevocable upon
the later of its signing or the acquisition of employment-related securities to which this election applies.


 


In signing this joint election, we agree
to be bound by its terms as stated above.


 





	 	 	     /     /
	Signature (Employee)	 	Date
	 	 	 
	 	 	 
		 	     /     /
	Signature (for and on behalf of the Company)	 	Date
	 	 	 
	 	 	 
		 	 
	Position in Company	 	 




 






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