<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  -------------

                                    FORM 10-Q

      (Mark One)

/X/   QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
      EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 1999

OR

/ /   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
      EXCHANGE ACT OF 1934

For the transition period from __________________  to  _________________

                         Commission file number 0-21168

                  CHROMATICS COLOR SCIENCES INTERNATIONAL, INC.
--------------------------------------------------------------------------------
             (Exact Name of Registrant as Specified in Its Charter)

          New York                                     13-3253392
--------------------------------------------------------------------------------
(State or Other Jurisdiction of          (I.R.S. Employer Identification Number)
Incorporation or Organization)

                  5 East 80th Street, New York, New York 10021
--------------------------------------------------------------------------------
                    (Address of principal executive offices)

                                 (212) 717-6544
--------------------------------------------------------------------------------
              (Registrant's Telephone Number, Including Area Code)


--------------------------------------------------------------------------------
              (Former Name, Former Address and Former Fiscal Year,
                          if Changed Since Last Report)

Indicate by check whether the registrant (1) has filed all reports required to
be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes /X/  No / /

                APPLICABLE ONLY TO ISSUERS INVOLVED IN BANKRUPTCY
                  PROCEEDINGS DURING THE PRECEDING FIVE YEARS:

Indicate by check whether the registrant has filed all documents and reports
required to be filed by Section 12, 13 or 15(d) of the Securities Exchange Act
of 1934 subsequent to the distribution of securities under a plan confirmed by
court. Yes / / No / / N/A

                      APPLICABLE ONLY TO CORPORATE ISSUERS:

Indicate the number of shares outstanding of each of the registrant's classes of
common stock, as of the latest practicable date: 15,535,481.


                                       1
<PAGE>

PART I -- FINANCIAL INFORMATION

Item 1. Financial Statements

          CHROMATICS COLOR SCIENCES INTERNATIONAL, INC. AND SUBSIDIARY
                           CONSOLIDATED BALANCE SHEETS

<TABLE>
<CAPTION>
                                                                September 30, 1999    December 31, 1998
                                                                ------------------    -----------------
                                                                    (Unaudited)             (Note 1)
                                ASSETS
<S>                                                                <C>                   <C>
CURRENT ASSETS:
    Cash and equivalents                                           $  5,113,200          $  3,929,800
    Accounts receivable                                                 253,200                92,300
    Inventories                                                       1,645,800               147,300
    Prepaid expenses and other assets                                    50,400                81,800
                                                                   ------------          ------------
         Total Current Assets                                         7,062,600             4,251,200

COLORMATE(Registered) UNITS                                                  --             1,820,100
PROPERTY AND EQUIPMENT, NET                                             649,500               301,700
SOFTWARE DEVELOPMENT COSTS, NET                                         575,100               546,000
PATENT COSTS, NET                                                       873,900               540,300
OTHER ASSETS                                                          1,145,600               418,900
                                                                   ------------          ------------
                                                                   $ 10,306,700          $  7,878,200
                                                                   ============          ============

            LIABILITIES AND STOCKHOLDERS' EQUITY

CURRENT LIABILITIES:
    Amounts payable to related party                               $    279,500          $    318,900
    Accounts payable and accrued expenses:
         Attorneys and accountants                                      209,400               673,000
         Consultants                                                     83,600               146,500
         Trade                                                           87,000               156,800
                                                                   ------------          ------------
            Total Current Liabilities                                   659,500             1,295,200
                                                                   ------------          ------------

LONG TERM DEBT:
    Accrued interest on senior convertible debentures                   320,800                    --
    Senior convertible debentures                                     3,450,800                    --
                                                                   ------------          ------------
                                                                      3,771,600                    --
                                                                   ------------          ------------
COMMITMENTS AND CONTINGENCIES

REDEEMABLE PREFERRED STOCK:
    Class A, Par Value $.01 per share:
         Authorized - 1,400,000 shares
         Issued and outstanding - 1,380,000 shares
            at par value and redemption value                            13,800                13,800
    Class B, Series 2  Convertible Preferred Stock, No Par
      Value:
         Authorized - 10,000,000 shares
         Issued and outstanding - 40,000 shares in 1999
         $115 redemption value                                        2,797,300                    --
                                                                   ------------          ------------
                                                                      2,811,100                13,800

SHAREHOLDERS' EQUITY
    Common Stock, par value $.001 per share:
         Authorized - 50,000,000 shares
         Issued and outstanding - 15,535,481 (1999)
            and 15,452,442 (1998) shares                                 15,500                15,400
    Capital in excess of par value                                   33,939,300            28,327,000
    Accumulated deficit                                             (30,890,300)          (21,773,200)
                                                                   ------------          ------------
         Total Shareholders' Equity                                   3,064,500             6,569,200
                                                                   ------------          ------------
                                                                   $ 10,306,700          $  7,878,200
                                                                   ============          ============
</TABLE>

           See accompanying notes to consolidated financial statements


                                       2
<PAGE>

          CHROMATICS COLOR SCIENCES INTERNATIONAL, INC. AND SUBSIDIARY
                      CONSOLIDATED STATEMENTS OF OPERATIONS
                                   (UNAUDITED)

<TABLE>
<CAPTION>
                                                              Three Months Ended September 30,      Nine Months Ended September 30,
                                                              -------------------------------       -------------------------------
                                                                  1999               1998               1999               1998
                                                              ------------       ------------       ------------       ------------
<S>                                                           <C>                <C>                <C>                <C>
Revenues:
      Sales                                                   $    362,100       $     46,200       $    362,700       $     46,400
      Interest income                                               73,700             88,000            157,400            312,800
                                                              ------------       ------------       ------------       ------------
                                                                   435,800            134,200            520,100            359,200
                                                              ------------       ------------       ------------       ------------
COSTS AND EXPENSES:
      Cost of sales                                                 46,300                 --             46,300                 --
      Medical regulatory expenses                                  494,800            202,100            968,100          1,032,500
      Patent application costs                                      35,100             59,000             83,000            186,300
      Research and development costs                               229,200            160,600            658,500            520,500
      Compensation costs relating to options
      granted to consultants (non cash)                            248,000            197,400            736,000            615,400
      Sales, marketing and promotion costs                         568,400            310,100          1,794,500            715,300
      General and administrative:
          Compensation - Officers and employees                    177,800            154,600            563,900            571,400
          Consultants                                               78,400             71,500            229,400            193,500
          Legal fees                                               205,700            401,800            757,800            730,000
          Accounting fees                                            8,200              7,500             55,300             39,800
          Rent and storage                                          74,000             72,200            222,400            192,300
          Insurance                                                 90,100             57,300            210,500            136,700
          Travel and entertainment                                  68,600             19,600             85,100             74,700
          Repairs and maintenance                                   30,500             38,500             86,200             64,000
          Depreciation and amortization                            138,800             28,500            196,700            103,000
          Payroll taxes                                             11,300             10,500             44,300             45,400
          Stock administrative fees                                 37,100              6,900             80,800             58,300
          Employee benefit plan                                          0             24,300              1,700            131,500
          Public relations                                          49,800            150,700            150,800            150,700
          Other                                                     65,800             59,700            222,400            154,500
      Interest and financing costs (primarily non-cash)            923,700              7,200          2,443,500             20,500
                                                              ------------       ------------       ------------       ------------
                                                                 3,581,600          2,040,000          9,637,200          5,736,300
                                                              ------------       ------------       ------------       ------------
NET LOSS                                                      $ (3,145,800)      $ (1,905,800)      $ (9,117,100)      $ (5,377,100)
                                                              ============       ============       ============       ============
NET LOSS TO COMMON STOCKHOLDERS:

NET LOSS                                                      $ (3,145,800)      $ (1,905,800)      $ (9,117,100)      $ (5,377,100)

DEEMED DIVIDEND FOR CLASS B, SERIES 2
       CONVERTIBLE PREFERRED STOCK                                  66,300                             1,341,300
                                                              ------------       ------------       ------------       ------------
NET LOSS TO COMMON STOCKHOLDERS                               $ (3,212,100)      $ (1,905,800)      $(10,458,400)      $ (5,377,100)
                                                              ============       ============       ============       ============

WEIGHTED AVERAGE NUMBER OF
       COMMON SHARES OUTSTANDING                                15,499,299         15,315,530         15,498,360         14,815,017
                                                              ============       ============       ============       ============
BASIC AND DILUTED LOSS PER SHARE                              $      (0.21)      $      (0.12)      $      (0.67)      $      (0.36)
                                                              ============       ============       ============       ============
</TABLE>

           See accompanying notes to consolidated financial statements


                                       3
<PAGE>

    CHROMATICS COLOR SCIENCES INTERNATIONAL, INC. AND SUBSIDIARY CONSOLIDATED
            STATEMENT OF CHANGES IN STOCKHOLDERS' EQUITY (DEFICIENCY)
                                   (UNAUDITED)

<TABLE>
<CAPTION>
                                                                         Common Stock
                                                                -------------------------------
                                                                 Number of                             Capital
                                                                   Shares                             in Excess         Accumulated
                                                                 Outstanding         Par Value       of Par Value         Deficit
                                                                ------------       ------------      ------------      ------------
<S>                                                               <C>              <C>               <C>               <C>
Balances, December 31, 1998                                       15,452,442       $     15,400      $ 28,327,000      $(21,773,200)

Nine Months Ended September 30, 1999:

          Net Loss                                                        --                 --                --        (9,117,100)

          Exercise of stock options and
              warrants                                                83,039                100           371,200                --

          Original issue discount on senior
              convertible debentures (below
              market conversion price)                                                                  3,575,000

          Original issue discount on Class B,
             convertible preferred stock
             (warrants and below market
             conversion price)                                                                          2,271,400

          Deemed dividend on Class B,
             convertible preferred stock                                                               (1,341,300)

          Compensation cost relating to options
             granted to consultants                                       --                 --           736,000                --
                                                                ------------       ------------      ------------      ------------

Balances, September 30, 1999                                      15,535,481       $     15,500      $ 33,939,300      $(30,890,300)
                                                                ============       ============      ============      ============
</TABLE>

           See accompanying notes to consolidated financial statements


                                       4
<PAGE>

          CHROMATICS COLOR SCIENCES INTERNATIONAL, INC. AND SUBSIDIARY
                      CONSOLIDATED STATEMENTS OF CASH FLOWS
                                   (UNAUDITED)

<TABLE>
<CAPTION>
                                                                                                     Nine Months Ended September 30,
                                                                                                      ------------------------------
                                                                                                          1999              1998
                                                                                                      -----------       -----------
<S>                                                                                                   <C>               <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
           Net Loss                                                                                   $(9,117,100)      $(5,377,100)
           Adjustments to reconcile net loss to net cash flows from operating activities:
           Depreciation and amortization                                                                  196,700           103,000
           Compensation cost relating to options granted to consultants                                   736,000           615,400
           Non-cash interest and financing costs                                                        2,052,900                --
           Changes in operating assets and liabilities:
                Accounts receivable                                                                      (246,200)               --
                Inventories                                                                              (684,400)             (200)
                Prepaid expenses and other assets                                                          31,400            10,900
                Other assets                                                                              (60,400)            8,600
                Accounts payable and accrued expenses                                                    (190,200)          166,000
                                                                                                      -----------       -----------
                     Net cash flows from operating activities                                          (7,281,300)       (4,473,400)
                                                                                                      -----------       -----------

CASH FLOWS FROM INVESTING ACTIVITIES:
           Software development costs                                                                     (81,400)         (269,900)
           Capitalized patent costs                                                                      (355,500)         (343,000)
           Purchase of property and equipment                                                            (157,700)          (72,500)
           Purchase of ColorMate(Registered) Units and deposits thereon                                        --          (830,800)
                                                                                                      -----------       -----------
                    Net cash flows from investing activities                                             (594,600)       (1,516,200)
                                                                                                      -----------       -----------

CASH FLOWS FROM FINANCING ACTIVITIES:
           Proceeds from issuance of common stock, net of related costs                                   371,300         3,016,500
           Proceeds (payments) of amounts payable to related party                                        (39,400)           19,100
           Proceeds from senior convertible debentures                                                  5,000,000                --
           Net proceeds from the issuance of preferred stock and warrants, net of costs                 3,727,400                --
           Payments of notes payable                                                                           --            (3,700)
                                                                                                      -----------       -----------
                    Net cash flows from financing activities                                            9,059,300         3,031,900
                                                                                                      -----------       -----------

NET CHANGE IN CASH AND EQUIVALENTS                                                                      1,183,400        (2,957,700)

CASH AND EQUIVALENTS, BEGINNING OF PERIOD                                                               3,929,800         9,225,400
                                                                                                      -----------       -----------

CASH AND EQUIVALENTS, END OF PERIOD                                                                   $ 5,113,200       $ 6,267,700
                                                                                                      ===========       ===========
SUPPLEMENTAL CASH FLOW INFORMATION
           Interest Paid                                                                              $    59,000       $     1,400
                                                                                                      ===========       ===========
</TABLE>

          See accompanying notes to consolidated financial statements


                                       5
<PAGE>

          CHROMATICS COLOR SCIENCES INTERNATIONAL, INC. AND SUBSIDIARY

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

Note 1 - Basis of Presentation:

Nature of Report - The consolidated balance sheet at the end of the preceding
fiscal year has been derived from the audited consolidated balance sheet
contained in the Company's Annual Report on Form 10-K for the fiscal year ended
December 31, 1998 and is presented for comparative purposes. All other financial
statements are unaudited. In the opinion of management, all adjustments, which
include only normal recurring adjustments necessary to present fairly the
financial position, results of operations and changes in cash flows, for all
periods presented have been made. The results of operations for interim periods
are not necessarily indicative of the operating results for the full year.

Footnotes - Certain footnote disclosures normally included in financial
statements prepared in accordance with generally accepted accounting principles
have been omitted in accordance with the published rules and regulations of the
Securities and Exchange Commission. These consolidated financial statements
should be read in conjunction with the financial statements and notes thereto
included in the Company's Annual Report on Form 10-K for the fiscal year ended
December 31, 1998.

Estimates and Uncertainties - The preparation of financial statements in
conformity with generally accepted accounting principles requires management to
make estimates and assumptions that affect the reported amounts of assets and
liabilities and disclosure of contingent assets and liabilities at the date of
the financial statements and the reported amounts of revenues and expenses
during the reporting period. Actual results, as determined at a later date,
could differ from those estimates. Estimates relate primarily to inventory
valuation and recoverability of the Company's tangible and intangible assets.

Principles of Consolidation - The consolidated financial statements include the
accounts of the Company and its wholly-owned subsidiary. All significant
intercompany accounts and transactions have been eliminated in consolidation.

Note 2 - Commitments and Contingencies:

Business Risks - Since its formation in 1984, the Company has been principally
engaged in color science technology research and development and licensing
activities, seeking mass market applications for its proprietary technology and
instrumentation. The Company's business encompasses all of the risks inherent in
the establishment of a new business enterprise, including a limited operating
history with significant competition possessing substantially greater resources.
Current and future operations also depend upon the continued employment of
certain key executives, the ability to further commercialize its proprietary
technology and products and the Company's ability to obtain sufficient revenues
and/or outside financing.

Operating Difficulties - Since 1989, the Company has incurred losses from
operations and net cash outflows from operations. The Company expects to license
its patents and proprietary technology, sell its equipment and market its
related services and products to ultimately overcome these difficulties.

On July 30, 1997, the Company was granted clearance by the FDA for commercial
marketing of the ColorMate(Registered) TLc-BiliTest(Registered) System for the
non-invasive detection and monitoring of bilirubin infant jaundice in newborns
by health care professionals in hospitals, pediatricians' offices and by home
healthcare agencies. On June 7, 1999, the Company executed a renewable,
five-year agreement with Datex-Ohmeda, Inc. and its Ohmeda Medical Division
("DO") pursuant to which the Company appointed DO as the exclusive distributor
in the United States of the Company's ColorMate(Registered)
TLc-BiliTest(Registered) System for noninvasive monitoring of bilirubin infant
jaundice in the hospital market, the non-consumer home healthcare market (in
which the test is administered solely by a healthcare professional), the
pediatrician office market and clinics within all such markets. The agreement
also applies to the Company's disposable calibration standard
(TLc-Lensette(Trademark)) that is used to calibrate each measurement taken by
the ColorMate(Registered) TLc-BiliTest(Registered) System and provides that the
Company will share in the sales revenues for both products. Terms of the
agreement include annual minimum market penetration performance standards and
purchasing and placement of quantities for both the ColorMate(Registered)
TLc-BiliTest(Registered) System and the TLc-Lensette(Trademark) calibration
standard. Sales under the agreement commenced in July 1999.

The Company anticipates incurring significant additional expenditures related to
manufacturing expenses, parts order, insurance, regulatory compliance and
staffing and marketing expenses for the sales division as production and
distribution continues over the next year. Management expects that taking into
account existing resources, including the financings in April 1999 and June 1999
and the second closing of the preferred stock financing in the amount of $4.0
million contemplated by the agreement executed in connection with the June 1999
preferred stock financing (see Note 4), revenues from future sales of the
ColorMate(Registered)


                                       6
<PAGE>

units, and payments received under the distribution agreement, the Company will
have sufficient liquidity at least until October 2000.

Legal Proceedings - Three putative class actions were commenced against the
Company and certain of its officers and directors in the Southern District of
New York. The first two actions were commenced in June 1998 and are captioned
L.F. Monk v. Chromatics Color Sciences International, Inc., Darby S. Macfarlane,
Arthur Guiry, David K. Macfarlane and Leslie Foglesong, C.A. No. 98 CV 4111
(S.D.N.Y.) and Daniel R. Marquis v. Chromatics Color Sciences International,
Inc., Darby S. Macfarlane, Arthur Guiry and Leslie Foglesong, C.A. No. 98 CV
4335 (S.D.N.Y.). The third action was commenced in August 1998 and is captioned
Joseph Grunberg v. Chromatics Color Sciences International, Inc., Darby S.
Macfarlane, Arthur Guiry, David K. Macfarlane and Leslie Foglesong, C.A. No. 98
Civ. 5646 (S.D.N.Y.)

The complaints were consolidated pursuant to the Consolidation Order entered by
the Court in December 1998. A consolidated amended complaint in the matter now
captioned In re Chromatics Color Sciences International, Inc. Securities
Litigation, Consolidated Matter File No. 98 Civ. 4111 (SHS), was filed and
served in January 1999 (the "Action").

Plaintiffs purport to bring the class action on behalf of all purchasers of the
common stock of the Company, between July 30, 1997 and June 9, 1998, seeking
damages for the alleged violation by defendants of Section 10(b) of the
Securities Exchange Act of 1934, 15 U.S.C. ss.78j(b), and Rule 10b-5 promulgated
thereunder, 17 C.F.R. ss.240.10b-5, and pursuant to Section 20(a) of the
Securities Exchange Act of 1934, 15 U.S.C. ss.78t(a), with respect to the
individual named defendants as "controlling persons." The complaint alleges that
the Company "embarked upon a scheme" to inflate the price of the Company's
Common Stock by making false and misleading statements concerning: (i) the new
and innovative nature of the Company's ColorMate(Registered)
TLc-BiliTest(Registered) System; (ii) the market size and revenue potential of
the ColorMate(Registered) TLc-BiliTest(Registered) System; and (iii) the
existence and status of negotiations with potential distributors of the
ColorMate(Registered) TLc-BiliTest(Registered) System. The allegations of the
complaint arise principally from a "report" prepared by Manuel I. Asensio of
Asensio & Company, Inc. that was disseminated at the close of the putative class
period.

Defendants have moved to dismiss the complaint, which motion is fully briefed
and is now pending before the court. Defendants believe that the claims
asserted against them are without merit and intend to vigorously defend this
action. No assurance can be given that the resolution of the Action and/or
future actions will not have a material adverse effect on the Company's results
of operations and liquidity. The Company has directors and officers insurance
which may cover a portion of the liability asserted in the Action. The Company
is exploring its legal remedies in respect to what it believes to be false
allegations against the Company made by short sellers of its stock; the Company
expects to incur significant expenses in this regard.

Note 3 - ColorMate(Registered) Units

As noted above, in June 1999 the Company entered into a distribution agreement
to sell ColorMate(Registered) TLc-BiliTest(Registered) Systems ("Systems") and
related TLc-Lensette(Trademark) calibration standards to DO. The agreement
called for the Company to provide a certain number of Systems to DO at no cost
until sold to serve as demo units or promotional units to assist in the sales
and marketing of the Systems. The Company maintains title of certain of these
Systems, while DO obtains ownership of the other Systems. The Company has
classified $264,600 in property and equipment, representing the cost of the
Systems for which it maintains title, and has classified $407,100 in other
assets, representing the cost of the remaining Systems. The amount classified in
other assets is being amortized over the life of the DO Agreement, 5 years. All
remaining amounts previously classified as ColorMate(Registered) Units on the
accompanying balance sheet has been classified as inventory, fixed assets,
promotional expense or other assets.

Note 4 - Private Placements:

On April 15, 1999 the Company issued an aggregate of $5,000,000 14% senior
convertible debentures due April 15, 2002 (the "Debentures") in a private
placement. Payments of interest on the outstanding principal amount of the
Debentures are due on the earlier of the maturity date or upon any conversion of
the Debentures into the Company's Common Stock. The accrued interest may be paid
either in cash, shares of the Company's Common Stock or a combination of Common
Stock and cash, at the option of the Company.

The outstanding principal amount of the Debentures (together with accrued
interest thereon) is not convertible until after the first anniversary of the
closing. At that time, the Debentures are convertible into shares of Common
Stock, at the option of the holder or holders thereof, at the conversion price
of $5.00. However, at any time prior to April 14, 2000, such portion of the
Debentures may be converted, at the option of the holder or holders thereof, as
shall result in the issuance, upon such conversion, of not more


                                       7
<PAGE>

than an aggregate of 200,000 shares of Common Stock. Subject to applicable
securities laws, the holder or holders of such shares, in the aggregate, may
only sell not more than an aggregate of 50,000 shares of such Common Stock
issued upon such conversion during any one month period ending prior to April
14, 2000. At any time after the 18 month anniversary of the closing, the Company
may prepay the entire amount of the Debentures or any portion thereof for a
prepayment price equal to the original principal amount of the Debentures plus
all accrued and unpaid interest. At any time after the 18 month anniversary of
the closing and prior to the Maturity Date, in the event the average closing bid
price (as reported on the Nasdaq SmallCap Market or such other principal market
or exchange on which the Common Stock is then traded) of the Company's Common
Stock for any 10 consecutive trading days equals or exceeds $10.29, the Company
can require conversion of the outstanding principal amount (together with
accrued interest) of the Debentures into Common Stock at a conversion price of
$5.00 per share. The Company filed a Form 8-K on April 30, 1999 relating to the
issuance of the Debentures. The Debentures resulted in an original issue
discount charge of approximately $3.6 million which will be amortized over one
year. Through September 30, 1999 the Company has amortized $2.0 million.

On June 15, 1999, the Company completed a private placement of 40,000 shares of
convertible preferred stock and warrants to purchase 220,690 shares of Common
Stock to a private investor for aggregate proceeds of $4 million. The shares of
convertible preferred stock issued on that date (the "Shares") are convertible
into shares of the Company's Common Stock at a price of $7.25 per share, subject
to adjustment for stock splits, combinations and similar recapitalizations
affecting the Company's Common Stock and to downward adjustment if the Company
issues or agrees to issue additional shares of the Company's Common Stock
(excluding options under the Company's option plan and certain other excluded
securities) at a price of less than $7.25 per share to the price at which the
Company issues or agrees to issue the lower-priced shares of the Company's
Common Stock or securities convertible or exchangeable for shares of the
Company's Common Stock. The Shares are redeemable in cash for an amount equal to
$115 per Share on the third anniversary of the date of initial issuance if not
sooner converted unless the Company elects in the Company's discretion to extend
the redemption date to the fifth anniversary of the date of initial issuance.
The Shares are subject to mandatory conversion into shares of the Company's
Common Stock at the Company's option at any time after December 15, 1999 if the
average closing bid price of the Company's Common Stock for ten consecutive
trading days equals or exceeds $10.88 per share. The Shares are not entitled to
any voting rights except as otherwise required by applicable law and are not
entitled to any dividend rights unless the Company elects to extend the
redemption date to the fifth anniversary of the date of initial issuance, in
which case dividends would accrue at the rate of 8% from and after the third
anniversary of the date of initial issuance which could be paid in shares of the
Company's Common Stock at the Company's option.

In addition to the Shares on June 15, 1999 the Company also issued an aggregate
of 220,690 warrants to purchase shares of the Company's Common Stock to a
private investor. An additional 50,000 warrants were issued to such investor as
compensation for services rendered in connection with the placement of the
Shares. The warrants issued on that date have a five-year term unless sooner
exercised. The warrants are exercisable for shares of the Company's Common Stock
at a price of $8.25 per share, subject to adjustment in the same circumstances
as the Shares described above and are subject to mandatory exercise into shares
of the Company's Common Stock at the Company's option at any time after December
15, 1999 if the average closing bid price of the Company's Common Stock measured
over twenty consecutive trading days equals or exceeds $16.50.

The Company also agreed to issue and sell an additional 40,000 shares of
convertible preferred stock and warrants to purchase 270,690 shares of the
Company's Common Stock to the same investor at a second closing.

The private placement has resulted in a deemed dividend charge of approximately
$3.0 million, resulting from a below market conversion price of preferred stock,
a redemption premium and warrants issued in connection with the private
placement, of this amount, approximately $1.3 million has been charged through
September 1999 and $1.7 million will be charged over the redemption period.

Item 2. Management's Discussion and Analysis of Financial Condition and Results
of Operations

Results of Operations

The Company incurred net losses of $3,145,800 and $1,905,800 for the three month
periods ended September 30, 1999 and 1998, respectively and $9,117,100 and
$5,377,100 for the nine month periods ended September 30, 1999 and 1998
respectively. Revenues have not been significant relative to the Company's
expenses incurred in implementing its business plan. Loss per share increased by
$0.31 in the nine month 1999 period compared to the nine month 1998 period,
negatively impacted by a non-cash dividend charge due to private placement
financing costs of $1,341,300 and positively impacted by the increase of 683,343
weighted average number of shares outstanding attributed to the exercise of
options and warrants.

The dollar increase in net loss in the three and nine month 1999 periods as
compared to the three and nine month 1998 periods is primarily attributable to
the Company's continuing implementation of its long-range business plan to seek
commercial


                                       8
<PAGE>

applications of its intellectual properties and technologies in the medical
field including an increase in costs regarding sales, marketing and promotional
costs, research and development, consulting and other related expenses regarding
regulatory compliance with respect to manufacturing and distribution of its
ColorMate(Registered) System, and non-cash financing costs in connection with
certain private placements.

Although the Company anticipates that the future expenses regarding FDA
application costs and related patent application costs should be significantly
less than amounts incurred prior to receipt of the initial FDA marketing
clearance, the Company will continue to incur significant additional costs and
expenses in connection with FDA manufacturing and other regulations, state
regulatory requirements and foreign market clearances and other requirements. In
addition, the Company expects to incur significant expenses relating to
manufacturing expenses, products liability insurance, legal and regulatory
compliance, including QSR/GMP quality system substantial compliance, as well as
research and development for new potential applications and implementation of
the next phase of its efforts to successfully commercialize the medical
application of its technology (see "Liquidity and Capital Resources"). Further,
the Company anticipates significantly higher legal expenses in connection with
its defense of certain class action suits that have been brought against the
Company and as the Company explores all of its potential legal remedies.

In the first nine months of 1999, the Company focused its resources on
implementation of its long-range business plan for medical applications of its
technologies. Shipments of the ColorMate(Registered) TLc-BiliTest(Registered)
Systems and TLc-Lensette(Trademark) calibration standards commenced in the third
quarter of 1999 in accordance with the distribution agreement the Company signed
in June, 1999 with DO.

In April 1999, the Company's lease and license agreement with Nordstrom, Inc.
expired in accordance with its terms. The Company had granted Nordstrom a
license to use the ColorMate(Registered) System to formulate and recommend
Nordstrom's "C2O Color to Order" line of proprietary cosmetic products, which
were to be introduced and evaluated over a three-month period. That three-month
evaluation period terminated upon the expiration of the license agreement.

Revenues for the quarter ended September 30, 1999 were $435,800, an increase of
$301,600 or 224.7% from revenues of $134,200 for the quarter ended September 30,
1998. Revenues for the nine months ended September 30, 1999 were $520,100, an
increase of $160,900 or 44.8% from revenues of 359,200 for the nine months ended
September 30, 1998. The primary reason for the increase in revenues during the
1999 periods as compared to the corresponding 1998 periods is due to an increase
in sales partially offset by a decrease in interest income. As some products
were shipped for promotional use or shipped under a deferred payment until sold
by the distributor, the revenues for such products were not realized in this
quarter, and some are carried as other assets. See Note 3 to the Financial
Statements. The sales revenue is comprised primarily of TLc-Lensette(Trademark)
calibration standards which were shipped in the third quarter under the
distribution agreement with DO.

For the three months ended September 30, 1999 medical regulatory expenses were
$494,800, an increase of $292,700 or 144.8% from medical regulatory expenses of
$202,100 for the three months ended September 30, 1998. Medical regulatory
expenses for the nine months ended September 30, 1999 were $968,100, a decrease
of $64,400 or 6.2% from medical regulatory expenses of $1,032,500 for the nine
months ended September 30, 1998. The primary reason for the decline in medical
regulatory expenses during the nine months ended September 30, 1999 as compared
to the corresponding 1998 periodperiod is the completion of certain initial
phases of manufacturing, requiring extensive regulatory compliance, including
ISO 9001 and the GSR/GMP quality manufacturing system for FDA compliance.

Research and development costs were $229,200 for the three months ended
September 30, 1999, an increase of $68,600 or 42.7% from research and
development costs of $160,600 for the three months ended September 30, 1998. For
the nine months ended September 30, 1999 research and development costs were
$658,500, an increase of $138,000 or 26.5% from research and development costs
of $520,500 for the nine months ended September 30, 1998. The primary reason for
the increase in research and development costs during the 1999 periods as
compared to the corresponding 1998 periods is further research and development
during the 1999 periods relating to the manufacturing of the Company's
ColorMate(Registered) TLc-BiliTest(Registered) System and increased efforts to
further develop the LED mass manufacturing prototype in accordance with the
distribution agreement recently signed.

Compensation costs relating to options granted to consultants were $248,000 for
the three months ended September 30, 1999, an increase of $50,600 or 25.6% from
compensation costs relating to options granted to consultants of $197,400 for
the three months ended September 30, 1998. For the nine months ended September
30, 1999 compensation costs relating to options granted to consultants were
$736,000, an increase of $120,600 or 19.6% from compensation costs relating to
options granted to consultants of $615,400 for the nine months ended September
30, 1999.

Sales, marketing and promotion costs were $568,400 for the three months ended
September 30, 1999, an increase of $258,300 or 83.3% from sales, marketing and
promotion costs of $310,100 for the three months ended September 30, 1998. For
the nine months ended September 30, 1999 sales, marketing and promotion costs
were $1,794,500, an increase of $1,079,200 or 150.9% from sales, marketing and
promotion costs of $715,300 for the nine months ended September 30, 1998. The
primary reasons for the increase in sales, marketing and promotion costs during
the 1999 periods as compared to the corresponding 1998 periods were the
commercial introduction of the Company's ColorMate(Registered)
TLc-BiliTest(Registered) System and the addition of the Company's sales force at
its medical division.


                                       9
<PAGE>

Interest and non-cash financing costs were $923,700 for the three months ended
September 30, 1999, an increase of $916,500 from interest and non-cash financing
costs of $7,200 for the three months ended September 30, 1998. For the nine
months ended September 30, 1999, interest and non-cash financing costs were
$2,443,500, an increase of $2,423,000 from interest and non-cash financing costs
for the nine months ended September 30, 1998. The primary reason for the
increase in interest and non-cash financing costs during the 1999 periods as
compared to the 1998 periods was the securing of financing by the Company
through senior convertible debentures, which resulted in a non-cash original
issue discount of $2,025,800 for the 1999 periods.

Liquidity and Capital Resources

At September 30, 1999 the Company had cash and cash equivalents of $5,113,200,
current assets of $7,062,600, working capital of $6,403,100, a current ratio of
10.71 to 1.0 and stockholders equity of $3,064,500. Cash and cash equivalents
increased by $1,183,400 from December 31, 1998 as a result of the private
placement financings consummated by the Company during the second quarter of
1999.

Cash used by operating activities for the nine months ended September 30, 1999
was $7,281,300, an increase of $2,807,900 from cash used by operating activities
of $4,473,400 for the nine months ended September 30, 1998. The primary reasons
for the increase in cash used by operating activities during the 1999 period as
compared to the 1998 period was a $1,079,200 increase in sales, marketing and
promotion costs, a $684,400 increase in inventory associated with the
introduction of the Company's ColorMate(Registered) TLc-BiliTest(Registered)
System, a $246,200 increase in accounts receivable and a $356,200 net decrease
in accounts payable.

The Company's primary source of liquidity during the nine months ended September
30, 1999 was the net proceeds from the private placements of convertible debt
and equity securities it consummated during the second quarter of 1999. As a
result of the Distribution Agreement the Company entered into with Datex-Ohmeda,
Inc. in June 1999 for the distribution of the Company's ColorMate(Registered)
TLc-BiliTest(Registered) System, the Company began to derive revenues from this
product during the third quarter of 1999. Management currently anticipates that
cash and cash equivalents, together with the anticipated revenues under the
Datex-Ohmeda Distribution Agreement and the financing in the amount of $4.0
million pursuant to the second closing contemplated by the agreement executed in
connection with the June 1999 preferred stock financing, will be adequate to
fund the Company's liquidity needs at least until October 2000, although there
can be no assurance of such result.

The total costs associated with the Company's Year 2000 compliance are not
expected to result in the Company's liquidity decreasing in any material way.
However, satisfactory remediation of Year 2000 issues is dependent upon many
factors, some of which are not completely within the Company's control. The
Company's current estimates of the impact of Year 2000 compliance on its
liquidity do not include costs that may result from the failure of third parties
with whom the Company has a material relationship to be Year 2000 compliant.
Should the Company's internal systems or systems of one or more significant
third parties fail to achieve Year 2000 compliance, the Company's liquidity
could be materially adversely affected.

Some of the information presented in or incorporated by reference in this report
constitutes "forward-looking statements" within the meaning of the Private
Securities Litigation Reform Act of 1995. Although the Company believes that its
expectations are based on reasonable assumptions, within the bounds of its
knowledge of its business and operations, there can be no assurance that actual
results will not differ materially from its expectations. Factors that could
cause actual results to differ from expectations include: (i) the inability of
the Company to secure additional financing, (ii) the failure of the Company's
manufacturing and distribution partners to perform their obligations, (iii)
government regulation and (iv) the loss of key personnel.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

No disclosure is required under this Item 3.


                                       10
<PAGE>

                           PART II - OTHER INFORMATION

Item 1. Legal Proceedings

Three putative class actions were commenced against the Company and certain of
its officers and directors in the Southern District of New York. The first two
actions were commenced in June1998 and are captioned L.F. Monk v. Chromatics
Color Sciences International, Inc., Darby S. Macfarlane, Arthur Guiry, David K.
Macfarlane and Leslie Foglesong, C.A. No. 98 CV 4111 (S.D.N.Y.) and Daniel R.
Marquis v. Chromatics Color Sciences International, Inc., Darby S. Macfarlane,
Arthur Guiry and Leslie Foglesong, C.A. No. 98 CV 4335 (S.D.N.Y.). The third
action was commenced in August 1998 and is captioned Joseph Grunberg v.
Chromatics Color Sciences International, Inc., Darby S. Macfarlane, Arthur
Guiry, David K. Macfarlane and Leslie Foglesong, C.A. No. 98 CIV. 5646
(S.D.N.Y.).

The complaints were consolidated pursuant to the Consolidation Order entered by
the Court in December 1998. A consolidated amended complaint in the matter now
captioned In re Chromatics Color Sciences International, Inc. Securities
Litigation, Consolidated Matter File No. 98 Civ. 4111 (SHS), was filed and
served in January 1999 (the "Action").

Plaintiffs purport to bring the Action on behalf of all purchasers of the common
stock of the Company, between July 30, 1997 and June 9, 1998, seeking damages
for the alleged violation by defendants of Section 10(b) of the Securities
Exchange Act of 1934, 15 U.S.C. ss.78j(b), and Rule 10b-5 promulgated
thereunder, 17 C.F.R. ss.240.10b-5, and pursuant to Section 20(a) of the
Securities Exchange Act of 1934, 15 U.S.C. ss.78t(a), with respect to the
individual named defendants as "controlling persons." The complaint alleges that
the Company "embarked upon a scheme" to inflate the price of the Company's
Common Stock by making false and misleading statements concerning: (i) the new
and innovative nature of the Company's ColorMate(Registered)
TLc-BiliTest(Registered) System; (ii) the market size and revenue potential of
the ColorMate(Registered) TLc-BiliTest(Registered) System; and (iii) the
existence and status of negotiations with potential distributors of the
ColorMate(Registered) TLc-BiliTest(Registered) System. The allegations of the
complaint arise principally from a "report" prepared by Manuel I. Asensio of
Asensio & Company, Inc. that was disseminated at the close of the putative class
period.

Defendants have moved to dismiss the Action which motion is fully briefed and is
now pending before the court. Defendants believe that the claims asserted
against them are without merit and intend to vigorously defend the Action. No
assurance can be given that the resolution of the Action and/or future actions
will not have a material adverse effect on the Company's results of operations
and liquidity. The Company has directors and officers insurance which may cover
a portion of the liability asserted in the Action. The Company is exploring its
legal remedies in respect to what it believes to be false allegations against
the Company made by short sellers of its stock; the Company expects to incur
significant expenses in this regard.

Item 2. Changes in Securities and Use of Proceeds.

Not Applicable.

Item 3. Defaults Upon Senior Securities.

None.

Item 4. Submission of Matters to a Vote of Security Holders.

None.

Item 5. Other Information.

None.


                                       11
<PAGE>

Item 6. Exhibits and Reports on Form 8-K.

3.1   Restated Articles of Incorporation of the Company, as amended
      (incorporated by reference to Exhibit 4.1 to the Company's Quarterly
      Report on 120-Q for the three months ended June 30, 1999).

3.2   By-Laws of the Company (incorporated by reference to Exhibit 3.1 to the
      Company's Registration Statement on Form S-1 (File No. 33-54256), filed on
      November 5, 1992, as amended).

27.1  Financial Data Schedule.

During the three month period ended September 30, 1999, the Company filed one
Current Report on Form 8-K on July 1, 1999.

                                 EXHIBIT INDEX A

          Exhibit No.              Document                             Page
          -----------              --------                             ----

             27.1                  Financial Data Schedule               13


                                   SIGNATURES

In accordance with the requirements of the Exchange Act, the registrant caused
this report to be signed on its behalf by the undersigned, thereunto duly
authorized.

                                   CHROMATICS COLOR SCIENCES INTERNATIONAL, INC.


Date:  November 15, 1999            By: /s/ Darby S. Macfarlane
                                    -----------------------------------------
                                          Darby S. Macfarlane
                                          Chief Executive Officer


Date:  November 15, 1999            By: /s/ Leslie Foglesong
                                    -----------------------------------------
                                          Leslie Foglesong
                                          Treasurer and Chief Financial
                                          and Principal Accounting Officer


                                       12