Exhibit 10.3



EXECUTION
VERSION



RESALE
REGISTRATION RIGHTS AGREEMENT



This
Resale Registration Rights Agreement, dated as of April 21, 2020 (this “Agreement”), has been
entered into by and among Senseonics Holdings, Inc., a Delaware corporation
(the “Company” or “Senseonics”) and the Purchasers (as defined below).



Background



In connection with
the Note Purchase and Exchange Agreement, dated as of April 21, 2020 (the “Purchase and Exchange Agreement”),
by and among the parties hereto, pursuant to which the Purchasers (as defined below) have agreed to exchange $24 million aggregate
principal amount of the Company’s outstanding 5.25% Senior Convertible Notes due 2025 for $15.675 million aggregate principal
amount of newly issued Second Lien Secured Notes (the “Notes”), 11,026,086 shares of Common Stock (as
defined below) and warrants to purchase up to 4,500,000 shares of Common Stock at an exercise price of $0.66 per share (the “Warrant
Conversion Shares”), the Company has agreed to provide to the Purchasers certain resale registration rights under
the Securities Act of 1933, as amended, and the rules and regulations thereunder (together, the “Securities Act”),
and applicable state securities laws with respect to the Warrant Conversion Shares.



Agreement



In light of the above,
the Company and the Purchasers hereby agree as follows:



1.Definitions.



As used in this Agreement,
the following terms will have the respective meanings set forth in this Section 1:



“Additional
Interest” has the meaning set forth in Section2(c)(iv).



“Advice”
has the meaning set forth in Section2(d)(iv)



“Business
Day” means (i) a day on which the Common Stock is traded on a Trading Market, (ii) if the Common Stock is not listed
on any Trading Market, a day on which the Common Stock is quoted in the over-the-counter market as reported by the National Quotation
Bureau Incorporated (or any similar organization or agency succeeding to its functions of reporting prices) or (iii) in the event
that the Common Stock is not listed or quoted as set forth in (i) and (ii) hereof, any day other than a Saturday, a Sunday or a
day on which banking institutions in The City of New York are authorized or required by law, regulation or executive order to remain
closed.



“Commission”
means the Securities and Exchange Commission or any successor agency.



“Common
Stock” means the Company’s common stock, par value $0.001 per share.



“Company”
has the meaning set forth in the preamble.



“Discontinuance
Notice” has the meaning set forth in Section3(d).





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“Effective
Date” means, with respect to any Registration Statement, the date on which the Commission first declares effective
such Registration Statement.



“Effectiveness
Deadline” means, with respect to a Registration Statement filed pursuant to Section2(a), forty-five(45) calendar
days after the Filing Deadline in the case of a filing on Form S-3 and sixty (60) calendar days after the Filing Deadline in the
case of a filing on Form S-1.



“Effectiveness
Period” has the meaning set forth in Section 2(a).



“Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.



“Filing
Deadline” means April 29, 2020.



“FINRA”
means the Financial Industry Regulatory Authority, Inc. or any successor organization performing similar functions.



“Holder”
or “Holders” means the holder or holders, as the case may be, from time to time of Registrable Securities.



“Indemnified
Party” has the meaning set forth in Section5(c).



“Indemnifying
Party” has the meaning set forth in Section5(c).



“Losses”
has the meaning set forth in Section5(a).



“Notes”
has the meaning set forth in the preamble.



“Proceeding”
means an action, claim, suit, investigation or proceeding (including, without limitation, an investigation or partial proceeding,
such as a deposition), whether commenced or threatened.



“Prospectus”
means the prospectus included in a Registration Statement (including, without limitation, any preliminary prospectus, any free-writing
prospectus and any prospectus that includes any information previously omitted from a prospectus filed as part of an effective
registration statement under the Securities Act), as amended or supplemented by any prospectus supplement, with respect to the
terms of the offering of any portion of the Registrable Securities covered by a Registration Statement, and all other amendments
and supplements to such prospectus, including post-effective amendments, and all material incorporated by reference or deemed to
be incorporated by reference in such prospectus.



“Purchase
and Exchange Agreement” has the meaning set forth in the preamble.



“Purchaser”
means the Purchasers named on Schedule 2.2 to the Purchase and Exchange Agreement.





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“Registrable
Securities” means the Warrant Conversion Shares. “Registrable Securities” also includes
any shares of capital stock issued or issuable with respect to the foregoing as a result of any stock split, stock dividend, recapitalization,
exchange or similar event or otherwise. As to any particular Registrable Securities, such securities shall cease to be Registrable
Securities when (i) the Commission has declared a Registration Statement covering such securities effective and such securities
have been disposed of pursuant to such effective Registration Statement; (ii) such securities are sold under circumstances in which
all of the applicable conditions of Rule 144 under the Securities Act are met and the legend restricting further transfer has been
removed from the certificate for such securities; or (iii) such securities are no longer outstanding.



“Registration
Default” has the meaning set forth in Section2(c)(iv).



“Registration
Statement” means a registration statement filed pursuant to the terms hereof and which covers the resale by the Holders,
including the Prospectus, amendments and supplements to such registration statement or Prospectus, including pre- and post-effective
amendments, all exhibits thereto and all material incorporated by reference (or deemed to be incorporated by reference) therein.
For the avoidance of doubt, “Registration Statement” means the initial registration statement described
above in this paragraph and any additional registration statement or registration statements that are needed to sell additional
Registrable Securities with the effect that the obligations of the Company under this Agreement also extend to such additional
registration statement or registration statements, in all cases, as specified in this Agreement.



“Rule 144”
means Rule 144 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended from time to time, or
any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule.



“Rule 415”
means Rule 415 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended from time to time, or
any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule.



“Rule 424”
means Rule 424 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended from time to time, or
any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule.



“Securities
Act” has the meaning set forth in the preamble.



“Selling
Holder Questionnaire” has the meaning set forth in Section2(d)(i).



“Senseonics”
has the meaning set forth in the preamble.



“Shares”
has the meaning set forth in the preamble.



“Subsequent
Form S-3” has the meaning set forth in Section3(n).



“Suspension
Notice” has the meaning set forth in Section2(b).



“Suspension
Period” has the meaning set forth in Section2(b).





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“Trading
Market” means whichever of the NYSE American, New York Stock Exchange, the Nasdaq Global Market, the Nasdaq Capital
Market, Nasdaq Global Select Market or such other United States registered national securities exchange on which the Common Stock
is listed or quoted for trading on the date in question.



2.Registration.



(a)Mandatory Registration. On or prior to the Filing
Deadline, the Company will prepare and file with the Commission a Registration Statement covering the resale of all Registrable
Securities for an offering to be made on a continuous basis pursuant to Rule 415. The Registration Statement will be on Form S-3
(except if the Company is not then eligible to register for resale the Registrable Securities on Form S-3, in which case such registration
will be on Form S-1, and if for any reason the Company is not then eligible to register for resale the Registrable Securities on
Form S-1, then another appropriate form for such purpose) and will contain (except if otherwise required pursuant to written comments
received from the Commission upon a review of such Registration Statement) a “Plan of Distribution” section,
substantially in the form attached hereto as Annex A, as the same may be amended in accordance with the provisions of this Agreement.
The Company will use its reasonable best efforts to cause the Registration Statement to be declared effective under the Securities
Act as soon as possible but, in any event, no later than the Effectiveness Deadline, and will use their reasonable best efforts
to keep the Registration Statement (or a Subsequent Form S-3) continuously effective under the Securities Act until such date when
all Registrable Securities covered by the Registration Statement cease to be Registrable Securities as determined by the counsel
to the Company (the “Effectiveness Period”).



(b)Suspension Periods. Notwithstanding Section 2(a),
the Company may, at any time, delay the filing or delay or suspend the effectiveness of a Registration Statement or, without suspending
such effectiveness, deliver a notice (a “Suspension Notice”) that instructs any selling Holders not to
sell any securities included in the Registration Statement or delay the filing of any amendment or supplement pursuant to Section
3, if the board of directors of the Company has determined and promptly notifies the selling Holders in writing that in its reasonable
good faith judgment (i) a material event has occurred or is likely to occur with respect to the Company that has not been publicly
disclosed and, if disclosed, could reasonably be expected to materially and adversely affect the Company and its ability to consummate
the registration of the resale of the Registrable Securities or (ii) such registration could reasonably be expected to materially
interfere with any material financing, acquisition, corporate reorganization, merger, tender offer or other significant transaction
involving the Company (a “Suspension Period”), by providing the selling Holders with written notice of
such Suspension Period and the reasons therefor. The Company will use its reasonable best efforts to provide such notice at least
ten (10) Business Days prior to the commencement of such a Suspension Period; provided, however, that in any event the Company
will provide such notice no later than the commencement of such Suspension Period; provided, further, that in no event will a Suspension
Period exceed 30 days and in no event shall the total number of days subject to a Suspension Period during any consecutive 12-month
period exceed 45 days. Any Suspension Period will not be deemed to end until the Holders have received a notice from the Company
stating that such Suspension Period has ended.





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(c)Additional Interest. The parties hereto agree
that the Holders will suffer damages if the Company fails to fulfill its obligations under this Section 2 and that, in such case,
it would not be feasible to ascertain the extent of such damages with precision. Accordingly, if:



(i)the Company does not file a Registration Statement by the Filing Deadline;



(ii)a Registration Statement is not declared effective by the Commission on or before the applicable Effectiveness Deadline;



(iii)the Company extends any Suspension Period beyond 45 days during any consecutive 12-month period; or



(iv)a Registration Statement is filed and declared effective but, during the applicable Effectiveness Period, a Registration
Statement is not effective for any reason or the Prospectus contained therein is not available for use for any reason, including
by reason of its withdrawal or termination pursuant to Section 3(e), or, other than by reason of a Suspension Period as provided
in Section 2(b), will fail to be usable for its intended purpose without such disability being cured within ten (10) Business Days
by an effective post-effective amendment to such Registration Statement, a supplement to the Prospectus, a report filed with the
Commission pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act that cures such failure or the effectiveness of a
Subsequent Form S-3, and either (x) the Company fails for any reason to satisfy the requirements of Rule 144(c)(1), including,
without limitation, the failure to satisfy the current public information requirement under Rule 144(c); or (y) the Company fails
to satisfy any condition set forth in Rule 144(i)(2) as a result of which any of the Holders are unable to sell Registrable Securities
without restriction under Rule 144 (including, without limitation, volume restrictions) (each such event referred to in foregoing
clauses (i) through (iv), a “Registration Default”), then in such event as partial relief for the damages
to any Holder by reason of any such delay in or reduction of its ability to sell the Registrable Securities and not as a penalty
(which remedy will not be exclusive of any other remedies available at law or equity), the Company hereby agrees to pay to each
Holder, subject to Section 2(d), aggregate additional interest (“Additional Interest”) equal to 0.50%
per annum during the 90-day period immediately following the occurrence of any Registration Default and shall increase by 0.50%
per annum during each subsequent 90-day period, provided that in no event shall the Additional Interest exceed 2.000% per annum,
on all outstanding Notes (and all outstanding Shares to the extent Shares have been issued with respect to any Notes prior to the
occurrence of the Registration Default and such Shares remain Registrable Securities); provided that any payment on Shares will
be calculated based on the principal amount of the Notes as a result of conversion of which such Shares have been issued; provided
further that any such Additional Interest will cease to accrue to Holders hereunder and under the Purchase and Exchange Agreement
when any such Registration Default will cease, be remedied or be cured. The Company will pay any Additional Interest as set forth
in, and subject to the terms and conditions of, the Purchase and Exchange Agreement.



(d)Holders’ Agreements. It will be a condition
of each Holder’s rights under this Agreement, and each Holder agrees, as follows:





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(i)Cooperation
 & Selling Holder Questionnaire. Such Holder will cooperate with the Company by, with reasonable promptness, supplying
information and executing documents relating to such selling Holder or the securities of the Company owned by such selling Holder
in connection with such registration which are customary for offerings of this type or is required by applicable laws or regulations,
including but not limited to furnishing to the Company a completed questionnaire in the form attached to this Agreement as Annex
B (a “Selling Holder Questionnaire”). The Company will not be required to include the Registrable Securities
of a Holder in a Registration Statement and will not be required to pay any Additional Interest or other damages under Section
2(c) to any Holder who fails to furnish to the Company a fully completed Selling Holder Questionnaire at least five (5) Business
Days prior to the applicable Filing Deadline.



(ii)Undertakings.
Such selling Holder will enter into any undertakings and take such other action relating to the conduct of the proposed offering
which the Company may reasonably request as being necessary to insure compliance with federal and state securities laws and the
rules or other requirements of FINRA.



(iii)Shelf
Sales. In connection with and as a condition to the Company’s obligations with respect to any shelf Registration Statement,
each Holder covenants and agrees that it will not offer or sell any such Registrable Securities under the Registration Statement
until the Registration Statement has been declared effective by the Commission and such Holder has provided a written notice to
the Company of such proposed sale. The Company and the Holders acknowledge and agree that in no way shall this clause limit Holder’s
ability to sell securities without using the Registration Statement.



(iv)Discontinuance
of Sales. Each Holder agrees by its acquisition of such Registrable Securities that, upon receipt of a Suspension Notice or
a Discontinuance Notice from the Company, such Holder will forthwith discontinue any offers and sales of such Registrable Securities
under the Registration Statement until such Holder’s receipt of the copies of the supplemented Prospectus and/or amended
Registration Statement or until it is advised in writing (the “Advice”) by the Company that the use
of the applicable Prospectus may be resumed, and, in either case, has received copies of any additional or supplemental filings
that are incorporated or deemed to be incorporated by reference in such Prospectus or Registration Statement. The Company and
the Holders acknowledge and agree that in no way shall this clause limit Holder’s ability to sell securities without using
the Registration Statement.



(e)Piggyback Registrations. Without limiting any
obligation of the Company, if (i) there is not an effective Registration Statement covering all of the Registrable Securities,
if the Prospectus contained therein is not available for use, or if Rule 144 is not available with respect to the Registrable Securities
and (ii) the Company shall determine to prepare and file with the Commission a registration statement or offering statement relating
to an offering for its own account or the account of others under the Securities Act of any of its equity securities (other than
on Form S-4 or Form S-8 (each as promulgated under the Securities Act) or their then equivalents relating to equity securities
to be issued solely in connection with any acquisition of any entity or business (or a business combination subject to Rule 145
under the Securities Act) or equity securities issuable in connection with the Company’s stock option or other employee benefit
plans), or a dividend reinvestment or similar plan or rights offering, then the Company shall deliver to each Holder a written
notice of such determination and, if within fifteen (15) calendar days after the date of the delivery of such notice, any such
Holder shall so request in writing, the Company shall include in such registration statement or offering statement all or any part
of such Shares constituting Registrable Securities that such Holder requests to be registered; provided, however, the Company shall
not be required to register any Shares pursuant to this Section 2(e) that are the subject of a then-effective Registration Statement.
The Company may postpone or withdraw the filing or the effectiveness of a piggyback registration at any time in its sole discretion.
The Company shall not grant piggyback registration rights to any holders of its Common Stock or securities that are convertible
into its Common Stock that are senior to the rights of the Holders set forth in this Section 2(e).





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3.Registration Procedures. In connection with the
Company’s obligations to effect a registration pursuant to Section 2(a), the Company and, as applicable, the Holders, will
do the following:



(a)FINRA Cooperation. The Company and the Holders
will cooperate and assist in any filings required to be made with FINRA.



(b)Right to Review Prior Drafts. Not less than ten
(10) Business Days prior to the filing of a Registration Statement or any related Prospectus or any amendment or supplement thereto,
the Company will furnish to each Holder copies of the “Selling Securityholders” and “Plan
of Distribution” sections of such documents (together with drafts of the Registration Statement or any related Prospectus
or any amendment or supplement thereto) in the form in which the Company proposes to file them, which sections and documents will
be subject to the review of each such Holder. Each Holder will provide comments, if any, within five (5) Business Days after the
date such materials are provided. The Company will not file a Registration Statement, any Prospectus or any amendments or supplements
thereto in which the “Selling Securityholders” or the “Plan of Distribution”
sections thereof differ in any material respect from the disclosure received from a Holder in its Selling Holder Questionnaire
(as amended or supplemented) or otherwise differ in any material respect from the drafts previously received by such Holder.



(c)Right to Copies. The Company will furnish to
each Holder, without charge, (i) at least one (1) conformed copy of each Registration Statement and each amendment thereto and
all exhibits to the extent requested by such Holder (excluding those previously furnished or incorporated by reference) promptly
after the filing of such documents with the Commission, except if such documents are available on EDGAR; and (ii) as many copies
of each Prospectus or Prospectuses (including each form of prospectus) and each amendment or supplement thereto as such Holder
may reasonably request. The Company hereby consents to the use of such Prospectus and each amendment or supplement thereto by each
of the selling Holders in connection with the offering and sale of the Registrable Securities covered by such Prospectus and any
amendment or supplement thereto.





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(d)Notices. The Company will notify each Holder
covered by the Registration Statement as promptly as reasonably practicable: (A) when the Prospectus or any prospectus supplement
or post-effective amendment has been filed, and with respect to the Registration Statement or any post-effective amendment, when
the same has become effective; (B) of any request by the Commission for any amendments or supplements to the Registration Statement
or the Prospectus or for additional information; (C) of the issuance by the Commission of any stop order suspending the effectiveness
of the Registration Statement or the initiation of any proceedings for that purpose; (D) if, at any time prior to the closing contemplated
by the Purchase and Exchange Agreement, it becomes aware that the representations and warranties of the Company contained in such
agreement cease to be true and correct; (E) of the receipt by the Company of any notification with respect to the suspension of
the qualification of the Registrable Securities for sale in any jurisdiction or the initiation or threatening of any proceeding
for such purpose; (F) of the happening of any event which it believes may make any statement made in the Registration Statement,
the Prospectus or any document incorporated therein by reference untrue, or of any material misstatement or omission, and which
requires the making of any changes in the Registration statement, the Prospectus or any document incorporated therein by reference
in order to make the statements therein not misleading; (G) upon the occurrence of a Suspension Period (items (C) through and including
(G) being a “Discontinuance Notice”); and (H) upon the conclusion of a Suspension Period.



(e)Withdrawal of Suspension Orders. The Company
will use its reasonable best efforts to respond as promptly as reasonably possible to any comments received from the Commission
with respect to any Registration Statement or any amendment thereto and to obtain the withdrawal of any order suspending the effectiveness
of the Registration Statement or the suspension of the qualification of the Registrable Securities for sale in any jurisdiction,
or to prevent any such suspension.



(f)Supplements & Amendments. Subject to Section
2(a), if required, based on the advice of the Company’s counsel, the Company will prepare a supplement or post-effective
amendment to a Registration Statement, the related Prospectus or any document incorporated therein by reference or file any other
required document or, if necessary, renew or refile a Registration Statement prior to its expiration, so that, as thereafter delivered
to the purchasers of the Registrable Securities, (A) the Prospectus will not contain an untrue statement of a material fact or
omit to state any material fact necessary to make the statements therein not misleading; (B) such Registration Statement remains
continuously effective as to the applicable Registrable Securities for its applicable Effectiveness Period (C) the related Prospectus
may be supplemented by any required prospectus supplement, and as so supplemented may be filed pursuant to Rule 424 and (D) the
Prospectus will be supplemented, if necessary, to update the disclosure of the number of shares that each Holder intends to sell,
reflecting prior resales in accordance with guidance of the staff of the Commission (as such guidance may be substituted for, amended
or supplemented by the staff of the Commission after the date of this Agreement). Furthermore, subject to a Holder’s compliance
with its obligations under Section 2(d)(i), the Company will take such actions as are required to name such Holder as a selling
Holder in a Registration Statement or any supplement thereto and to include (to the extent not theretofore included) in such Registration
Statement the Registrable Securities identified in such Holder’s Selling Holder Questionnaire.



(g)Listing. The Company will use its reasonable
best efforts to cause all Registrable Securities covered by the Registration Statement to be listed on each securities exchange
on which identical securities issued by the Company are then listed if requested by the Holder thereof and, if not so listed, to
be approved for listing on the national securities exchange on which the Company’s Common Stock is then listed.





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(h)Transfer Agent & Registrar. The Company will
provide and cause to be maintained a transfer agent and registrar for all Registrable Securities covered by such Registration Statement
from and after a date not later than the Effective Date of such Registration Statement.



(i)Certificates.
The Company will cooperate with the Holders to facilitate the timely preparation and delivery of any certificates representing
Registrable Securities to be delivered to a transferee pursuant to any Registration Statement, which certificates will be free
of all restrictive legends, and to enable such Registrable Securities to be in such denominations and registered in such names
as any such Holders may reasonably request.



(j)CUSIPs. The Company, if necessary, will use its
best efforts to provide a CUSIP number for the Registrable Securities, not later than the Effective Date of the Registration Statement.



(k)[Reserved.]



(l)Legal
Counsel. Holders will have the right to select one legal counsel, at the Company’s expense pursuant to Section
4, to review any Registration Statement or Prospectus prepared pursuant to Section 2 or this Section 3, which will be such counsel
as designated by the Holders of a majority of the Registrable Securities then outstanding. The Company will reasonably cooperate
with such legal counsel’s reasonable requests in performing their obligations under this Agreement.



(m)Blue Sky. The Company will, prior to any public
offering of Registrable Securities, use its reasonable best efforts to register or qualify or cooperate with the selling Holders
in connection with the registration or qualification (or exemption from such registration or qualification) of such Registrable
Securities for offer and sale under the securities or blue sky laws (“Blue Sky”) of all jurisdictions
within the United States that the selling Holders request in writing be covered, to keep each such registration or qualification
(or exemption therefrom) effective during the applicable Effectiveness Period and to do any and all other acts or things necessary
or advisable to enable the disposition in such jurisdictions of the Registrable Securities covered by any Registration Statement;
provided, that the Company will not be required to qualify generally to do business in any jurisdiction where it is not then so
qualified or to become subject to any material tax in any such jurisdiction where it is not then so subject.



(n)Subsequent Form S-3. If, at the time of filing
of a Registration Statement, the Company is not eligible to use Form S-3 for transactions involving secondary offerings and the
Company is not otherwise eligible to incorporate by reference prospectively into such Registration Statement, then at such time
as the Company becomes eligible to register transactions involving secondary offerings on Form S-3, the Company may, in its sole
discretion, file in accordance with the procedures outlined in this Section 3, including but not limited to all required notices
to the Holders, an additional Registration Statement on Form S-3 to cover resales pursuant to Rule 415 of the Registrable Securities
(a “Subsequent Form S-3”), and, when such Subsequent Form S-3 has been filed with the Commission, the
Company may, concurrently with its filing of a request for acceleration of effectiveness of such Subsequent Form S-3, withdraw
or terminate the original Registration Statement; provided, however, that nothing in this Section 3(n) will be interpreted to limit
the Company’s obligations pursuant to Section 2(a).





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4.Registration Expenses.



All
fees and expenses incident to the performance of or compliance with this Agreement by the Company will be borne by the Company
whether or not any Registrable Securities are sold pursuant to a Registration Statement including, without limitation: (i) all
registration and filing fees (including, without limitation, fees and expenses (A) with respect to filings required to be made
with any Trading Market on which the Common Stock is then listed for trading, (B) related to compliance with applicable state securities
or Blue Sky laws and (C) incurred in connection with the preparation or submission of any filing with FINRA); (ii) printing expenses
(including, without limitation, expenses of printing certificates for Registrable Securities and of printing Prospectuses); (iii)
messenger, telephone and delivery expenses; (iv) fees and disbursements of counsel for the Company and counsel pursuant to Section3(l); (v) Securities Act liability insurance, if the Company so desires such insurance; (vi) fees and expenses of all other
persons retained by the Company in connection with the consummation of the transactions contemplated by this Agreement and (vii)
all of the Company’s own internal expenses incurred in connection with the consummation of the transactions contemplated
by this Agreement (including, without limitation, all salaries and expenses of its officers and employees performing legal or accounting
duties), the expense of any annual audit and the fees and expenses incurred in connection with the listing of the Registrable Securities
on any securities exchange as required hereunder; provided, however, that each selling Holder will pay (i) all underwriting discounts,
commissions, fees and expenses and all transfer taxes with respect to the Registrable Securities sold by such selling Holder; (ii)
any fees and expenses of legal counsel other than counsel pursuant to Section 3(l) and (iii) all other expenses incurred by such
selling Holder and incidental to the sale and delivery of the shares to be sold by such Holder.



5.Indemnification.



(a)Indemnification by the Company. The Company will,
notwithstanding any termination of this Agreement, indemnify and hold harmless each Holder, the officers, directors, partners,
members and shareholders of each Holder and each person who controls any Holder (within the meaning of Section 15 of the Securities
Act or Section 20 of the Exchange Act) and the directors and officers of any such controlling persons, to the fullest extent permitted
by applicable law, from and against any and all losses, claims, damages, liabilities, costs (including, without limitation, reasonable
costs of preparation and reasonable attorneys’ fees) and expenses (collectively, “Losses”), as
incurred, arising out of or based upon, in the case of the Registration Statement or in any amendments thereto, any untrue or alleged
untrue statement of a material fact contained therein or any omission or alleged omission to state therein a material fact required
to be stated therein to make the statements not misleading, or in the case of any Prospectus or form of prospectus, or in any amendment
or supplement thereto, or in any preliminary prospectus, any untrue or alleged untrue statement of a material fact contained therein
or any omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements
therein, in light of the circumstances under which they were made, not misleading, except to the extent, but only to the extent,
that such untrue statements or omissions (1) are made in reliance upon and in conformity with written information furnished to
the Company by or on behalf of any Holder expressly for use in a Registration Statement, or to the extent that such information
relates to such Holder or such Holder’s proposed method of distribution of Registrable Securities and was reviewed and approved
in writing by such Holder for use in the Registration Statement, such Prospectus or such form of Prospectus (it being understood
and agreed that the only such information furnished to the Company by or on behalf of any Holder consists of the information described
in Annex A hereto, as may be amended in accordance with the provisions of this Agreement, for this purpose) or (2) resulted from
the use by any Holder of an outdated or defective Prospectus after the Company has notified such Holder in writing that such Prospectus
is outdated or defective and prior to the receipt by such Holder of an Advice or an amended or supplemented Prospectus, but only
if and to the extent that following the receipt of the Advice or the amended or supplemented Prospectus the misstatement or omission
giving rise to such Loss would have been corrected.





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(b)Indemnification by Holders. Each Holder will,
severally and not jointly, indemnify and hold harmless the Company, its directors, officers, partners, members and shareholders
and each person who controls the Company (within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange
Act) and the directors and officers of such controlling person, in each case to the fullest extent permitted by applicable law
from and against all Losses, as incurred, arising solely out of or based upon, in the case of the Registration Statement or in
any amendments thereto, any untrue or alleged untrue statement of a material fact contained therein or any omission or alleged
omission to state therein a material fact required to be stated therein to make the statements not misleading, or in the case of
any Prospectus or form of prospectus, or in any amendment or supplement thereto, or in any preliminary prospectus, any untrue or
alleged untrue statement of a material fact contained therein or any omission or alleged omission to state therein a material fact
required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were
made, not misleading to the extent, but only to the extent, that such untrue statements or omissions (1) are made in reliance upon
and in conformity with written information furnished to the Company by or on behalf of any Holder expressly for use in a Registration
Statement or Prospectus, or to the extent that such information relates to such Holder or such Holder’s proposed method of
distribution of Registrable Securities and was reviewed and approved in writing by such Holder for use in the Registration Statement
or Prospectus (it being understood and agreed that the only such information furnished to the Company by or on behalf of any Holder
consists of the information described in Annex A hereto, as may be amended in accordance with the provisions of this Agreement,
for this purpose) or (2) resulted from the use by such Holder of an outdated or defective Prospectus after the Company has notified
such Holder in writing that the Prospectus is outdated or defective and prior to the receipt by such Holder of an Advice or an
amended or supplemented Prospectus, but only if and to the extent that following the receipt of the Advice or the amended or supplemented
Prospectus the misstatement or omission giving rise to such Loss would have been corrected; provided, however, that the obligation
to indemnify will be several and not joint and in no event will the liability of any selling Holder hereunder be greater in amount
than the dollar amount of the net proceeds received by any such selling Holder upon the sale of the Registrable Securities under
the Registration Statement giving rise to such indemnification obligation.



(c)Conduct of Indemnification Proceedings. In order
for a Person (the “Indemnified Party”) to be entitled to any indemnification provided for under this
Agreement in respect of, arising out of or involving a claim or demand made by any Person against the Indemnified Party (a “Claim”),
such Indemnified Party must notify the indemnifying party (“Indemnifying Party”) in writing, and in reasonable
detail, of the Claim as promptly as reasonably possible after receipt by such Indemnified Party of notice of the Claim; provided,
however, that failure to give such notification on a timely basis shall not affect the indemnification provided hereunder except
to the extent the Indemnifying Party shall have been actually materially prejudiced as a result of such failure. Thereafter, the
Indemnified Party shall deliver to the Indemnifying Party, promptly after the Indemnified Party’s receipt thereof, copies
of all notices and documents (including court filings and related papers) received by the Indemnified Party relating to the Claim.





11







If a Claim is made
against an Indemnified Party, the Indemnifying Party shall be entitled to participate in the defense thereof and, if it so chooses
and acknowledges its obligation in writing to indemnify the Indemnified Party therefor, to assume at its cost the defense thereof
with counsel selected by the Indemnifying Party and reasonably satisfactory to the Indemnified Party and to settle such suit, action,
claim or proceeding in its discretion with an unconditional full release of the Indemnified Party and no admission of fault, liability,
culpability or a failure to act by or on behalf of the Indemnified Party. Notwithstanding any acknowledgment made pursuant to the
immediately preceding sentence, the Indemnifying Party shall continue to be entitled to assert any limitation to the amount of
Losses for which the Indemnifying Party is responsible pursuant to its indemnification obligations. Should the Indemnifying Party
so elect to assume the defense of a Claim, the Indemnifying Party shall not be liable to the Indemnified Party for legal expenses
subsequently incurred by the Indemnified Party in connection with the defense thereof unless (i) the Indemnifying Party has materially
failed to defend, contest or otherwise protest in a timely manner against Claims or (ii) such Indemnified Party reasonably objects
to such assumption on the grounds that there are defenses available to it which are different from or in addition to the defenses
available to such Indemnifying Party and, as a result, a conflict of interest exists. Subject to the limitations in the preceding
sentence, if the Indemnifying Party assumes such defense, the Indemnified Party shall have the right to participate in the defense
thereof and to employ counsel, at its own expense, separate from the counsel employed by the Indemnifying Party, it being understood,
however, that the Indemnifying Party shall control such defense. The Indemnifying Party shall be liable for the fees and expenses
of counsel employed by the Indemnified Party for any period during which the Indemnifying Party has not assumed the defense thereof.
If the Indemnifying Party chooses to defend any Claim, all the parties hereto shall cooperate in the defense or prosecution of
such Claim. Such cooperation shall include the retention and (upon the Indemnifying Party’s request) the provision to the
Indemnifying Party of records and information which are reasonably relevant to such Claim, and making employees available on a
mutually convenient basis to provide additional information and explanation of any material provided hereunder. Whether or not
the Indemnifying Party shall have assumed the defense of a Claim, the Indemnified Party shall not admit any liability with respect
to, or settle, compromise or discharge, such Claim without the Indemnifying Party’s prior written consent (which consent
shall not be unreasonably withheld).



The obligations of
the Company and the Holders under this Section 5 shall survive completion of any offering of Registrable Securities pursuant to
a Registration Statement and the termination of this Agreement. The Indemnifying Party’s liability to any such Indemnified
Party hereunder shall not be extinguished solely because any other Indemnified Party is not entitled to indemnity hereunder.





12







(d)Contribution. If a claim for indemnification
under Section 5(a) or 5(b) is unavailable to an Indemnified Party (by reason of public policy or otherwise), then each Indemnifying
Party, in lieu of indemnifying such Indemnified Party, will contribute to the amount paid or payable by such Indemnified Party
as a result of such Losses, in such proportion as is appropriate to reflect the relative fault of the Indemnifying Party and Indemnified
Party in connection with the actions, statements or omissions that resulted in such Losses as well as any other relevant equitable
considerations. The relative fault of such Indemnifying Party and Indemnified Party will be determined by reference to, among other
things, whether any action in question, including any untrue or alleged untrue statement of a material fact or omission or alleged
omission of a material fact, has been taken or made by, or relates to information supplied by, such Indemnifying Party or Indemnified
Party, and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such action,
statement or omission. The amount paid or payable by a party as a result of any Losses will be deemed to include, subject to the
limitations set forth in Section 5(c), any reasonable attorneys’ or other reasonable fees or expenses incurred by such party
in connection with any Proceeding to the extent such party would have been indemnified for such fees or expenses if the indemnification
provided for in Section 5(a) or 5(b) was available to such party in accordance with its terms. The parties hereto agree that it
would not be just and equitable if contribution pursuant to this Section 5 were determined by pro rata allocation or by any other
method of allocation that does not take into account the equitable considerations referred to in this Section 5. Notwithstanding
the provisions of this Section 5, no Holder will be required to contribute, in the aggregate, any amount in excess of the amount
by which the proceeds actually received by such Holder from the sale of the Registrable Securities subject to the Proceeding exceeds
the amount of any damages that such Holder has otherwise been required to pay by reason of such untrue or alleged untrue statement
or omission or alleged omission. No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities
Act) shall be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation.



(e)Other. The indemnity and contribution agreements
contained in this Section 5 are in addition to any liability that the Indemnifying Parties may have to the Indemnified Parties.



6.Miscellaneous.



(a)Notices. All notices or other communications
hereunder will be in writing and will be given by (i) personal delivery, (ii) courier or other delivery service which obtains a
receipt evidencing delivery, (iii) registered or certified mail (postage prepaid and return receipt requested) or (iv) facsimile
or similar electronic device, to such address as may be designated from time to time by the relevant party, and which will initially
be:



(i)in the case of the Company:



| | Senseonics Holdings,
Inc.          | 
| | ---------------------------------- | 
| | 24051 Seneca
Meadows Parkway       | 
| | Germantown, MD
20876               | 
| | Facsimile: (301)
515-0988          | 
| | Attention: Chief
Financial Officer | 
| |                                    | 
| | With a copy to:                    | 
| |                                    | 
| | Cooley LLP                         | 
| | 11951 Freedom
Drive                | 
| | Reston, VA 20190                   | 
| | Facsimile: (703)
456-8100          | 
| | Attention: Christian
E. Plaza      | 





13







(ii)in
the case of the Purchasers, to the address set forth below each such Purchaser’s name on the signature page attached hereto.



Notices to Holders
shall be provided to the address specified on such Holder’s Selling Holder Questionnaire. All notices and other communications
will be deemed to have been given (i) if delivered by the United States mail, three (3) Business Days after mailing (five (5) Business
Days if delivered to an address outside of the United States), (ii) if delivered by a courier or other delivery service, one (1)
Business Day after dispatch (two (2) Business Days if delivered to an address outside of the United States) and (iii) if personally
delivered or sent by facsimile or similar electronic device, upon receipt by the recipient or its agent or employee (which, in
the case of a notice sent by facsimile or similar electronic device, will be the time and date indicated on the transmission confirmation
receipt). No objection may be made by a party to the manner of delivery of any notice actually received in writing by an authorized
agent of such party.



(b)Governing Law; Jurisdiction; Jury Trial; etc.
This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of New York. Each party hereby
irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in The City of New York, Borough of Manhattan,
for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed
herein, and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally
subject to the jurisdiction of any such court, that such suit, action or proceeding is brought in an inconvenient forum or that
the venue of such suit, action or proceeding is improper. Each party hereby irrevocably waives personal service of process and
consents to process being served in any such suit, action or proceeding by mailing a copy thereof to such party at the address
for such notices to it under this Agreement and agrees that such service will constitute good and sufficient service of process
and notice thereof. Nothing contained herein will be deemed to limit in any way any right to serve process in any manner permitted
by law. Each party hereby irrevocably waives any right it may have, and agrees not to request, a jury trial for the adjudication
of any dispute hereunder or in connection with or arising out of this Agreement or any transaction contemplated hereby.



(c)Remedies. In the event of a breach by the Company
of its obligations under this Agreement, each Holder, in addition to being entitled to exercise all rights granted by law, including
recovery of damages, will be entitled to specific performance of its rights under this Agreement. The Company agrees that monetary
damages would not be adequate compensation for any loss incurred by reason of a breach by it of any of the provisions of this Agreement
and hereby waives the defense in any action for specific performance that a remedy at law would be adequate.



(d)Complete Agreement; Modifications. This Agreement
and any documents referred to herein or executed contemporaneously herewith constitute the parties’ entire agreement with
respect to the subject matter hereof and supersede all agreements, representations, warranties, statements, promises and understandings,
whether oral or written, with respect to the subject matter hereof. This Agreement may be amended, altered or modified only by
a writing signed by the Company and the Holders of a majority of the Registrable Securities then outstanding.





14







(e)Additional Documents. Each party hereto agrees
to execute any and all further documents and writings and to perform such other actions which may be or become necessary or expedient
to effectuate and carry out this Agreement.



(f)Third-Party Beneficiaries. None of the provisions of this Agreement will be for the benefit of, or enforceable
by, any third-party beneficiary, except with respect to the Holders.



(g)Successors and Assigns. Except as provided herein
to the contrary, this Agreement will be binding upon and inure to the benefit of the parties, their respective successors and permitted
assigns.



(h)Waivers Strictly Construed. With regard to any
power, remedy or right provided herein or otherwise available to any party hereunder (a) no waiver or extension of time will be
effective unless expressly contained in a writing signed by the waiving party and (b) no alteration, modification or impairment
will be implied by reason of any previous waiver, extension of time, delay or omission in exercise, or other indulgence.



(i)Severability. The validity, legality or enforceability
of the remainder of this Agreement will not be affected even if one or more of the provisions of this Agreement will be held to
be invalid, illegal or unenforceable in any respect.



(j)Attorneys’
Fees. Should any litigation be commenced (including any proceedings in a bankruptcy court) between the parties hereto
or their representatives concerning any provision of this Agreement or the rights and duties of any person or entity hereunder,
the party or parties prevailing in such proceeding will be entitled, in addition to such other relief as may be granted, to the
attorneys’ fees and court costs incurred by reason of such litigation.



(k)Headings. The Section headings in this Agreement
are inserted only as a matter of convenience, and in no way define, limit, extend or interpret the scope of this Agreement or of
any particular Section.



(l)Counterparts.
This Agreement may be executed simultaneously in two or more counterparts, each of which will be deemed an original, but all of
which together will constitute one and the same instrument.



[Remainder
of page intentionally left blank, signature pages to follow]





15







In
Witness Whereof, the parties have executed this Resale Registration Rights Agreement as of the date first written above.



| | SENSEONICS HOLDINGS, INC.
| | -------------------------
| |                          
| |                          
| | By:                      
| |                          
| |                          







[Signature
Page to Resale Registration Rights Agreement]













In
Witness Whereof, the parties have executed this Resale Registration Rights Agreement as of the date first written above.



| | PURCHASER:                                                                          
| | ------------------------------------------------------------------------------------
| |                                                                                     
| | Highbridge Tactical Credit Master Fund,
                                        L.P.
| |                                                                                     
| | By: Highbridge Capital Management, LLC                                              
| |                                                                                     
| | By:                                                                                 
| |                                                                                     
| | Name:                                                                               
| |                                                                                     
| | Title:                                                                              





[Signature
Page to Resale Registration Rights Agreement]

















pLANOF DISTRIBUTION



We are registering
the Securities covered by this prospectus on behalf of the Selling Securityholders. All costs, expenses and fees connected with
the registration of these Securities will be borne by us. Any brokerage commissions and similar expenses connected with selling
the Securities will be borne by the Selling Securityholders. The Selling Securityholders may offer and sell the Securities covered
by this prospectus from time to time in one or more transactions. The term “Selling Securityholders”
includes pledgees, donees, transferees and other successors-in-interest who may acquire Securities through a pledge, gift, partnership
distribution or other non-sale related transfer from the Selling Securityholders. The Selling Securityholders will act independently
of the Company in making decisions with respect to the timing, manner and size of each sale. These transactions include:



| | · | through one or more underwriters or dealers in a public offering and sale by them, whether individually
or through an underwriting syndicate led by one or more managing underwriters;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | in “at the market offerings” within the meaning of Rule 415(a)(4) under the Securities
Act, to or through a market maker or into an existing trading market, on an exchange or otherwise;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | directly to a limited number of purchasers or to a single purchaser;
| | - | --------------------------------------------------------------------



| | · | through agents;
| | - | ---------------



| | · | by delayed delivery contracts or by remarketing firms;
| | - | ------------------------------------------------------



| | · | ordinary brokerage transactions and transactions in which the broker solicits purchasers;
| | - | -----------------------------------------------------------------------------------------



| | · | purchases by a broker-dealer as principal and resale by the broker-dealer for its own account pursuant
to this prospectus;
| | - | --------------------------------------------------------------------------------------------------------------------------



| | · | exchange or over-the-counter distributions in accordance with the rules of the exchange or other
market;
| | - | --------------------------------------------------------------------------------------------------------



| | · | block trades in which the broker-dealer attempts to sell the Securities as agent but may position
and resell a portion of the block as principal to facilitate the transaction;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | transactions in options, swaps or other derivatives that may or may not be listed on an exchange;
| | - | -------------------------------------------------------------------------------------------------



| | · | a combination of any such method of sale; or
| | - | --------------------------------------------



| | · | any other method permitted pursuant to applicable law.
| | - | ------------------------------------------------------



In connection with
distributions of the Securities or otherwise, the Selling Securityholders may:





1







| | · | sell the Securities:
| | - | --------------------



| | · | in negotiated transactions;
| | - | ---------------------------



| | · | in one or more transactions at a fixed price or prices, which may be changed from time to time;
| | - | -----------------------------------------------------------------------------------------------



| | · | at market prices prevailing at the times of sale;
| | - | -------------------------------------------------



| | · | at prices related to such prevailing market prices; or
| | - | ------------------------------------------------------



| | · | at negotiated prices;
| | - | ---------------------



| | · | sell the Securities:
| | - | --------------------



| | · | on a national securities exchange;
| | - | ----------------------------------



| | · | in the over-the-counter market; or
| | - | ----------------------------------



| | · | in transactions otherwise than on an exchange or in the over-the-counter market, or in combination;
| | - | ---------------------------------------------------------------------------------------------------



| | · | sell the Securities short and/or deliver the Securities to close out short positions;
| | - | -------------------------------------------------------------------------------------



| | · | enter into option or other transactions with broker-dealers or other financial institutions which
require the delivery to them of Securities covered by this prospectus, which they may in turn resell; and
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | pledge Securities to broker-dealers or other financial institutions, which, upon a default, they
may in turn resell.
| | - | --------------------------------------------------------------------------------------------------------------------



The Selling Securityholders
may also resell all or a portion of the Securities in open market transactions in reliance upon Rule 144 under the Securities Act
of 1933, as amended, or the Securities Act, as permitted by that rule, Section 4(a)(1) under the Securities Act, if available,
or any other exemption from the registration requirements that become available, rather than under this prospectus.



If underwriters are
used in the sale of any Securities, such Securities will be acquired by the underwriters for their own account and may be resold
from time to time in one or more transactions described above. Securities may be either offered to the public through underwriting
syndicates represented by managing underwriters or directly by underwriters. We may use underwriters with whom we have a material
relationship. As applicable, we will describe in each accompanying prospectus supplement the name of the underwriter(s) and the
nature of any such relationship(s).





2







If a dealer is used
in an offering of Securities, the dealer may purchase the securities, as principal. The dealer may then resell the Securities to
the public at varying prices to be determined by the dealer at the time of sale.



Securities may be sold
directly or through agents designated from time to time. We will name any agent involved in the offering and sale of such shares
and we will describe any commissions paid to the agent in the prospectus supplement. Unless the prospectus supplement states otherwise,
the agent will act on a best-efforts basis for the period of its appointment.



Underwriters, dealers
and agents may be entitled to indemnification by us against certain civil liabilities, including liabilities under the Securities
Act, or to contribution with respect to payments made by the underwriters, dealers or agents, under agreements between us and the
underwriters, dealers and agents.



Underwriters who participate
in the distribution of Securities may be granted an option to purchase additional Securities in connection with the distribution.



Underwriters, dealers
or agents may receive compensation in the form of discounts, concessions or commissions from us or our purchasers, as their agents
in connection with the sale of securities. These underwriters, dealers or agents may be considered to be underwriters under the
Securities Act. As a result, discounts, commissions or profits on resale received by the underwriters, dealers or agents may be
treated as underwriting discounts and commissions. Each accompanying prospectus supplement will identify any such underwriter,
dealer or agent and describe any compensation received by them from us. Any initial public offering price and any discounts or
concessions allowed or re-allowed or paid to dealers may be changed from time to time.



In connection with
sales of Securities, the Selling Securityholders may enter into hedging transactions with broker-dealers or other financial institutions,
which may in turn engage in short sales of Securities in the course of hedging in positions they assume. The Selling Securityholders
may also sell Securities short and the Selling Securityholders may deliver Securities covered by this prospectus to close out short
positions and to return borrowed Securities in connection with such short sales. The Selling Securityholders may also loan or pledge
Securities to broker-dealers that in turn may sell such Securities, to the extent permitted by applicable law. The Selling Securityholders
may also enter into option or other transactions with broker-dealers or other financial institutions or the creation of one or
more derivative securities which require the delivery to such broker-dealer or other financial institution of Securities offered
by this prospectus, which Securities such broker-dealer or other financial institution may resell pursuant to this prospectus (as
supplemented or amended to reflect such transaction).



The Selling Securityholders
may, from time to time, pledge or grant a security interest in some or all of the Securities owned by them and, if they default
in the performance of their secured obligations, the pledgees or secured parties may offer and sell the Securities from time to
time pursuant to this prospectus or any amendment to this prospectus under Rule 424(b)(3) or other applicable provision of the
Securities Act, amending, if necessary, the list of Selling Securityholders to include the pledgee, transferee or other successors
in interest as Selling Securityholders under this prospectus. The Selling Securityholders may also may transfer and donate Securities
in other circumstances in which case the transferees, donees, pledgees or other successors in interest will be the selling beneficial
owners for purposes of this prospectus.





3







Any underwriter may
engage in over-allotment transactions, stabilizing transactions, short-covering transactions and penalty bids in accordance with
Regulation M under the Exchange Act of 1934.



Underwriters, broker-dealers
or agents who may become involved in the sale of Securities may engage in transactions with, and perform other services for, us
in the ordinary course of their business for which they receive compensation.



In effecting sales,
the Selling Securityholders may engage broker-dealers or agents, who may in turn arrange for other broker-dealers to participate.
Broker-dealers or agents may receive commissions, discounts or concessions from the Selling Securityholders and/or from the purchasers
of Securities for whom the broker-dealers may act as agents or to whom they sell as principal, or both. The compensation to a particular
broker-dealer may be in excess of customary commissions. To our knowledge, there is currently no plan, arrangement or understanding
between any Selling Securityholders and any broker-dealer or agent regarding the sale of any Securities by the Selling Securityholders.



The Selling Securityholders,
any broker-dealers or agents and any participating broker-dealers that act in connection with the sale of the Securities covered
by this prospectus may be “underwriters” under the Securities Act with respect to those Securities and will be subject
to the prospectus delivery requirements of that Act. Any profit that the Selling Securityholders realize, and any compensation
that any broker-dealer or agent may receive in connection with any sale, including any profit realized on resale of Securities
acquired as principal, may constitute underwriting discounts and commissions. If the Selling Securityholders are deemed to be underwriters,
the Selling Securityholders may be subject to certain liabilities under statutes including, but not limited to, Section 11, 12
and 17 of the Securities Act and Section 10(b) and Rule 10b-5 under the Exchange Act.



The securities laws
of some states may require the Selling Securityholders to sell the Securities in those states only through registered or licensed
brokers or dealers. These laws may also require that we register or qualify the Securities for sale in those states unless an exemption
from registration and qualification is available and the Selling Securityholders and we comply with that exemption. In addition,
the anti-manipulation rules of Regulation M under the Securities Exchange Act of 1934 may apply to sales of Securities in the market
and to the activities of the Selling Securityholders and their affiliates. Regulation M may restrict the ability of any person
engaged in the distribution of the Securities to engage in market-making activities with respect to the Securities. All of the
foregoing may affect the marketability of the Securities and the ability of any person to engage in market-making activities with
respect to the Securities.



If any Selling Securityholder
notifies us that he has entered into any material arrangement with a broker-dealer for the sale of Securities through a block trade,
special offering, exchange distribution, over-the-counter distribution or secondary distribution, or a purchase by a broker or
dealer, we will file any necessary supplement to this prospectus to disclose:





4







| | · | the number of Securities involved in the arrangement;
| | - | -----------------------------------------------------



| | · | the terms of the arrangement, including the names of any underwriters, dealers or agents who purchase
Securities, as required;
| | - | ------------------------------------------------------------------------------------------------------------------------------



| | · | the proposed selling price to the public;
| | - | -----------------------------------------



| | · | any discount, commission or other underwriting compensation;
| | - | ------------------------------------------------------------



| | · | the place and time of delivery for the Securities being sold;
| | - | -------------------------------------------------------------



| | · | any discount, commission or concession allowed, reallowed or paid to any dealers; and
| | - | -------------------------------------------------------------------------------------



| | · | any other material terms of the distribution of Securities.
| | - | -----------------------------------------------------------



In addition, if the
Selling Securityholder notifies us that a donee, pledgee, transferee or other successor-in-interest of the Selling Securityholder
intends to sell more than [ ] Securities, we will file a supplement to this prospectus.





5







SENSEONICS
HOLDINGS, INC.
Selling Securityholder Notice and Questionnaire



The undersigned beneficial
owner of common stock, $0.001 par value per share (the “Common Stock”) and/or securities, of Senseonics Holdings,
Inc. (the “Company”) understands that the Company has filed or intends to file with the Securities and Exchange
Commission (the “Commission”) a Registration Statement for the registration and resale of the Registrable Securities,
in accordance with the terms of the Registration Rights Agreement, dated as of April 21, 2020 (the “Registration Rights
Agreement”), among the Company and the Purchasers (as defined therein). A copy of the Registration Rights Agreement is
available from the Company upon request at the address set forth below. All capitalized terms used and not otherwise defined herein
will have the meanings ascribed thereto in the Registration Rights Agreement.



The undersigned hereby
provides the following information to the Company and represents and warrants that such information is accurate:



1.Name.



| | (a) | Full Legal Name of Selling Securityholder
| | --- | -----------------------------------------



| |  | 
| |  | 



| | (b) | Full Legal Name of Registered Holder (if not the same as (a)
above) through which Registrable Securities Listed in Item 3 below are held:
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------



| |  | 
| |  | 





| | (c) | Full Legal Name of Natural Control Person (which means a natural
person who directly or indirectly alone or with others has power to vote or dispose of the securities covered by the questionnaire):
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | 
| |  | 



2.Address for Notices to Selling Securityholder:



| | Name: | 
| | ----- | 



| | Address: | 
| | -------- | 
| |         



| | Telephone: | 
| | ---------- | 



| | Fax: | 
| | ---- | 



| | Contact Person : | 
| | ---------------- | 







1







3.Beneficial
Ownership of Registrable Securities:



| | (a) | Type and Amount of Registrable Securities Beneficially Owned:
| | --- | -------------------------------------------------------------



4.Broker-Dealer
Status:



| | (a) | Are you a broker-dealer?
| | --- | ------------------------



Yes ̈ No  ̈



Note: If yes,
the Commission’s staff has indicated that you should be identified as an underwriter in the Registration Statement.



| | (b) | Are you an affiliate of a broker-dealer?
| | --- | ----------------------------------------



Yes ̈ No  ̈



| | (c) | If you are an affiliate of a broker-dealer, do you certify that
you bought the Registrable Securities in the ordinary course of business, and at the time of the purchase of the Registrable Securities
to be resold, you had no agreements or understandings, directly or indirectly, with any person to distribute the Registrable Securities?
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Yes
 ̈ No  ̈



Note: If no,
the Commission’s staff has indicated that you should be identified as an underwriter in the Registration Statement.



| | 5. | Beneficial Ownership of Other Securities of the Company Owned by the Selling Securityholder.
| | -- | --------------------------------------------------------------------------------------------



Except as set
forth below in this Item 5, the undersigned is not the beneficial or registered owner of any securities of the Company other than
the Registrable Securities listed above in Item 3.



Type and Amount of
Other Securities Beneficially Owned by the Selling Securityholder:



| | 
| | 
| | 



6.Relationships
with the Company:



Except as set forth
below, neither the undersigned nor any of its affiliates, officers, directors or principal equity holders (owners of 5% of more
of the equity securities of the undersigned) has held any position or office or has had any other material relationship with the
Company (or its predecessors or affiliates) during the past three years.



| | State any
exceptions here: | 
| | -------------------------- | 



| |  | 
| |  | 
| |  | 



The undersigned agrees
to promptly notify the Company of any inaccuracies or changes in the information provided herein that may occur subsequent to the
date hereof and prior to the Effective Date for the Registration Statement.



By signing below, the
undersigned consents to the disclosure of the information contained herein in its answers to Items 1 through 6 and the inclusion
of such information in the Registration Statement and the related prospectus. The undersigned understands that such information
will be relied upon by the Company in connection with the preparation or amendment of the Registration Statement and the related
prospectus.





2









In
Witness Whereof the undersigned, by authority duly given, has caused this Notice and Questionnaire to be executed and
delivered either in person or by its duly authorized agent.



|Dated: | Beneficial
Owner:
|------ | -----------------
|       |                  
|       |                  
|       | By:              
|       | Name:            
|       | Title:           



PLEASE FAX A COPY OF
THE COMPLETED AND EXECUTED NOTICE AND QUESTIONNAIRE, AND RETURN THE ORIGINAL BY OVERNIGHT MAIL, TO:



| | Senseonics Holdings, Inc.          | 
| | ---------------------------------- | 
| | 24051 Seneca Meadows Parkway       | 
| | Germantown, MD 20876               | 
| | Facsimile: (301) 515-0988          | 
| | Attention: Chief Financial
Officer | 



3