Exhibit 4.35


 





THE
SYMBOL “[***]” DENOTES PLACES WHERE CERTAIN IDENTIFIED


INFORMATION
HAS BEEN EXCLUDED FROM THE EXHIBIT BECAUSE IT IS BOTH (i)


NOT
MATERIAL, AND (ii) WOULD LIKELY CAUSE COMPETITIVE HARM TO THE


COMPANY
IF PUBLICLY DISCLOSED


 


SECOND AMENDMENT TO


EXCLUSIVE PATENT LICENSE AGREEMENT


 


THIS SECOND AMENDMENT
TO EXCLUSIVE PATENT LICENSE AGREEMENT (the “Second Amendment”) is made effective as of ___________, 2019 by
and between:


 


Versitech Limited, a company incorporated
and existing under the laws of Hong Kong with its office at Room 405A, Cyberport 4, 100 Cyberport Road, Hong Kong (the “Licensor”);
and


 


Acticule Life Sciences Limited, with
incorporation number CB-324541, a company incorporated and existing under the laws of the Cayman Islands, with its registered office
at Floor 4, Willow House, Cricket Square, Grand Cayman KY1-9010, Cayman Islands with its management office at Floor 17, Guangdong
Investment Tower, 148 Connaught Road, Central, Hong Kong (the “LICENSEE”).


 


W I T N E S S E T H


 


WHEREAS, the
LICENSOR and the LICENSEE entered into that certain Exclusive Patent License Agreement dated as of October 18, 2017 (HKU Ref. No.
IP662) (as set forth in Appendix A), as amended by the First Amendment of the Exclusive Patent License Agreement dated as
of June 7, 2018 (HKU Ref. No. VER343-18 & IP662) (as set forth in Appendix B) (together, the “Agreement”);


 


WHEREAS, the
LICENSEE and the LICENSOR desire to further amend the Agreement as follows.


 


NOW, THEREFORE,
the parties hereto, in consideration of the mutual promises herein contained and for other good and valuable consideration, the
receipt and sufficiency of which is hereby acknowledged, hereby agree to amend the Agreement as follows:


 


1. Definitions.
Unless otherwise specified herein, each term used herein that is defined in the Agreement shall have the meaning assigned to such
term in the Agreement.


 


2. Amendments.
The following amendments have been newly entered into by the parties (the “New Amendments”):


 


The following is
added to Clause (B) of the RECITALS:


 


LICENSOR is
the wholly-owned subsidiary of the University of Hong Kong (“HKU”) and the technology transfer company of HKU.
To facilitate the commercialization of LICENSED PATENT, HKU has assigned all its rights, title and interest in and to LICENSED
PATENT to LICENSOR;


 






     


     


    

 


Section 1.16 of
the Agreement is hereby replaced by the following:


 


		1.16	“INITIAL LICENSED PATENT” shall mean:



 


		(i)	The United States and foreign patents, patent applications, and provisional applications listed
in Schedule 1, and all applications and patents claiming priority thereto or common priority therewith and any resulting
patents therefrom; and



 


		(ii)	any divisions, reissues, reexaminations, renewals, continuations, continuations-in-part and extensions
of the patent applications or patent listed in Schedule 1 including their relevant international equivalents thereof and
any patents that result therefrom.



 


For clarity,
INITIAL LICENSED PATENT shall exclude any LICENSEE OWNED IMPROVEMENT and JOINT IMPROVEMENT (as defined below).


 


The following Sections
are added to Section 1 of the Agreement: 


 


		1.29	“JOINT IMPROVEMENT” shall mean an invention and/or knowhow that is (a) an IMPROVEMENT
jointly made by employees of HKU and employees of the LICENSEE, (b) an IMPROVEMENT made solely by employees of the Sponsor using
HKU administered funds or facilities; or (c) any other intellectual property otherwise agreed by the LICENSOR and LICENSEE in an
agreement or in writing to be a JOINT IMPROVEMENT for purposes of this Agreement.



 


		1.30	“ELECTED LICENSED PATENT” shall mean:



 


		(i)	any United States and foreign patents, patent applications, and provisional applications on JOINT
IMPROVEMENT subject to an Elected License (as defined in Clause 6.4 below), and
all applications and patents claiming priority thereto or common priority therewith and any resulting patents therefrom; and



 


		(ii)	any divisions, reissues, reexaminations, renewals, continuations, continuations-in-part and extensions
of the patent applications or patent under (i) including their relevant international equivalents thereof and any patents that
result therefrom.



 


For clarity,
the Elected License shall be signed by the LICENSEE and LICENSOR in the format set
out in Appendix C hereof.


 


		1.31	“LICENSED PATENT” shall mean the INITIAL LICENSED PATENT and the ELECTED LICENSED
PATENT (as defined above).



 






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The following is
added to Section 4.1.2 of the Agreement:


 


For each Elected
License covering one invention in the TERRITORY (not for each TERRITORY of an ELECTED LICENSED PATENT), LICENSEE shall pay to
LICENSOR an upfront fee of [***] within thirty (30) days from the election. Such UPFRONT FEE is non-refundable.




 


Section 4.1.3 of
the Agreement is hereby replaced by the following: 


 


		4.1.3	Royalties. LICENSEE shall pay to
LICENSOR a royalty (“ROYALTY”) equal to [***] of NET
SALES of LICENSED PRODUCT covered only by the INITIAL LICENSED PATENTS in the TERRITORY by LICENSEE or its AFFILIATES. For LICENSED
PRODUCT that is also covered by any number of ELECTED LICENSED PATENTS under one or more Elected
License, the ROYALTY shall be adjusted as follows:





 


	Number of Elected License	 	Adjusted ROYALTY under this Agreement
	0	 	[***]
	1	 	[***]
	2	 	[***]
	3	 	[***]
	4 or more	 	[***]


 


For the avoidance
of doubt and subject to the Sublicense Royalty as set forth in this Clause 4.1.3, income generated from NET SALES of LICENSED PRODUCT
does not include income generated from SUBLICENSE INCOME.


 


ROYALTY shall
be payable for each REPORTING PERIOD and shall be due to LICENSOR within sixty (60) days of the end of each REPORTING PERIOD. ROYALTY
shall only be payable once with respect to the same unit of LICENSED PRODUCT.


 


Such ROYALTY
shall be paid, on a LICENSED PRODUCT by LICENSED PRODUCT and country by country basis.


 


Section 6 of the
Agreement is hereby replaced by the following:


 


		6.	LICENSEE OWNED IMPROVEMENT AND JOINT IMPROVEMENT



 


		6.1	If LICENSEE solely makes an IMPROVEMENT that is not a JOINT IMPROVEMENT (“LICENSEE OWNED
IMPROVEMENT”), LICENSEE shall immediately inform LICENSOR thereof. All rights, title, and interest in and to LICENSEE
OWNED IMPROVEMENT shall be vested in, belong to and remain as the exclusive property of the LICENSEE. LICENSOR shall be entitled
to use LICENSEE OWNED IMPROVEMENT for academic and research purposes only.



 






    3


     


    

 


		6.2	Provided that such LICENSEE OWNED IMPROVEMENT made by LICENSEE do not incorporate or contain, in
part or in whole, the LICENSED PATENT, LICENSEE shall own such LICENSEE OWNED IMPROVEMENT and shall be free to register any intellectual
property rights for such LICENSEE OWNED IMPROVEMENT and to license these LICENSEE OWNED IMPROVEMENT to third parties.



 


		6.3	With respect to JOINT IMPROVEMENT, each Party shall promptly disclose to the other Party all JOINT
IMPROVEMENT, including any invention disclosures or other similar documents, submitted to it by its or its Affiliates’ employees,
agents or independent contractors describing inventions that are JOINT IMPROVEMENT, and all information relating to such inventions
to the extent necessary for the preparation, filing and prosecution of any Patent with respect to such invention. Upon the disclosure
of a JOINT IMPROVEMENT hereunder, the Parties shall promptly discuss such JOINT IMPROVEMENT and (a) confirm its status as a JOINT
IMPROVEMENT in light of the ownership principles set forth under this Clause 6, and (b) determine whether to file a patent application
claiming such JOINT IMPROVEMENT.



 


		6.4	JOINT IMPROVEMENT shall be jointly owned on an equal share (50/50) basis between LICENSOR on the
one hand and LICENSEE on the other hand (or by their respective Affiliate and/or assignee). LICENSEE shall have the first right
to file a patent application on a JOINT IMPROVEMENT in the names of both Parties. All expenses incurred in obtaining and maintaining
any patent on such JOINT IMPROVEMENT (“the Expenses”) shall be equally shared except that if one Party (“the
Discontinuing Party”) declines to share in such expenses, the other Party (“the Continuing Party”)
may take over the prosecution and maintenance thereof, at its own expense, provided that title to the patent remains in the names
of both Parties. In the event that the Discontinuing Party receives any commercialization income from any third party while the
Continuing Party cannot recover all or part of the Expenses from any commercialization income, the Discontinuing Party shall reimburse
the Continuing Party all the unreimbursed Expenses incurred by the Continuing Party within three months from the date of receipt
of the said commercialization income.



 





Within
three (3) months after the date on which the JOINT IMPROVEMENT is disclosed to the LICENSEE by the LICENSOR or the date of filing
of a patent application on the JOINT IMPROVEMENT by the LICENSEE pursuant to first paragraph of Clause 6.4 above (whichever is
earlier) (“Option Period”), or subject to a payment of [***] by
the LICENSEE to the LICENSOR per disclosure of JOINT IMPROVEMENT within the Option Period, LICENSOR shall extend the Option Period
for a further twenty four (24) months, whichever is applicable, the LICENSEE shall have the right, but not the obligation, to give
an exercise notice to LICENSOR to elect an exclusive license to LICENSOR’s interest in the said JOINT IMPROVEMENT (each,
an “Elected License”). Each Elected
License shall not include more than one JOINT IMPROVEMENT. Once an exclusive license on a JOINT IMPROVEMENT is elected,
the JOINT IMPROVEMENT shall become ELECTED LICENSED PATENT. On the other hand, if LICENSEE does not exercise election to license
within the Option Period, each Party shall have the independent, unrestricted right to license to third parties any such JOINT
IMPROVEMENT without accounting to the other Party. 




 






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3. Date of Effectiveness.
This Second Amendment will become effective as of the date first written above when the LICENSOR shall have received counterparts
of this Second Amendment duly executed and delivered by the parties hereto. Notwithstanding the above, the New Amendments to the
Agreement set forth in this Second Amendment is expressly made retroactive to the Effective Date of the Agreement.


 


4. Effect of Amendment.
Except as expressly amended by this Second Amendment, all of the terms and provisions of the Agreement are and shall remain in
full force and effect and are hereby ratified and confirmed by the parties hereto. Without limiting the generality of the forgoing,
the amendments contained herein will not be construed as an amendment to or waiver of any other provision of the Agreement or as
a waiver of or consent to any further or future action on the part of any party hereto that would require the waiver or consent
of any other party hereto. Each reference in the Agreement to “this Agreement”, “the Agreement”, “hereunder”,
“hereof”, “herein” or words of like import will mean and be a reference to the Agreement as amended by
this Second Amendment.


 


5. Governing Law.
This Amendment is governed by and construed in accordance with, the laws of Hong Kong.


 


6. Counterparts.
This Second Amendment may be executed in two counterparts or by separate instruments and all of such counterparts and instruments
shall constitute one agreement, binding on all of the parties hereto.


 


IN WITNESS WHEREOF,
the parties hereto have caused this Second Amendment to be duly executed on the date first above written.


  




    5


     


    

 


	ACTICULE LIFE SCIENCES LIMITED 	 
	 	 
	By:	 	 
	 	Name: Mr. Ian Huen	 
	 	Title: Director	 
	 	 	 
	VERSITECH LIMITED 	 
	 	 
	By:	 	 
	 	Name:	 
	 	Title:  	 


 




     


     


    

 


Appendix A


Exclusive Patent License Agreement
(IP00662)


 


 




     


     


    

 


Appendix B


First Amendment to Exclusive Patent
License Agreement (IP00662;VER343-18)


 


 




     


     


    

  


Appendix C


Elected License Template


 


ELECTED LICENSE


 


Date:


 


The LICENSEE hereby gives exercise notice
to the LICENSOR to elect an exclusive license to LICENSOR’s interest in the Joint Improvement with particulars below:


 


Title: [insert] (Articule Ref No. [insert],
Versitech Ref No. [insert])


 


		1.	US Patent Application No. [insert] filed on [insert]



		2.	PCT Patent Application No. [insert] filed on [insert]



 


Pursuant to Clause 6.4 of the Exclusive
Patent License Agreement dated October 18, 2017 (HKU Ref. IP662), as amended by the First Amendment of the Exclusive Patent License
Agreement dated as of June 7, 2018 and Second Amendment of the Exclusive Patent License Agreement dated as [], the Joint Improvement
listed above shall become ELECTED LICENSED PATENT and all the terms and conditions of the said Exclusive Patent License Agreement
shall apply.


 


	Signed by LICENSEE	 
	ACTICULE LIFE SCIENCES LIMITED 	 
	 	 	 
	By:	 	 
	 	Name: Mr. Ian Huen	 
	 	Title: Director	 
	 	 
	Acknowledged by LICENSOR	 
	VERSITECH LIMITED 	 
	 	 
	By:	 	 
	 	Name:	 
	 	Title: