**EXHIBIT      10.4**

**AMENDMENT      TO**

**DISTRIBUTION      AGREEMENT**

**Dated      April 3, 2002**

**This      Amendment No. 2**
**Medi-Hut      Co., Inc.**
**Syntho      Pharmaceuticals, Inc.**

**RECITALS**

|   | A. | Medi                and Syntho executed and delivered a Distribution Agreement dated                as of                November 20, 2001 (the “Agreement”) pursuant to which Medi agreed to                exclusively distribute Subject Technology (as defined in paragraph                1.1 of                the Agreement) and Syntho agreed to manufacture Subject                Technology. |
|--------|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | B. | Medi                and Syntho executed and delivered an Amendment No. 1 to the Distribution                Agreement dated as of February 7, 2002 (the “Agreement”) pursuant to which                the Parties desired to amend the Agreement in the particulars set                forth in                paragraph 4.1 of the Agreement. |
|--------|----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | C. | The                Parties desire to further amend the Agreement in the particulars                set forth                in paragraph 4.1 of the Agreement. |
|--------|----|----------------------------------------------------------------------------------------------------------------------------------------------------------------|

**NOW,      THEREFORE,**

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**IN      WITNESS WHEREOF,**

|                                  |                                        |                                      |
|---------------------------------------|---------------------------------------------|-------------------------------------------|
|                                  | **MEDI-HUT              CO., INC.**         |
|                             |                                   |                                 |
| Date: April              3, 2002 | By:                               | /s/ Joseph              A. Sanpietro |
|                                  |                                             |
|                                  | Joseph              A. Sanpietro, President |

|                                    |                                            |                                   |
|-----------------------------------------|-------------------------------------------------|----------------------------------------|
|                                    |                                            |                                   |
|                                    | **SYNTHO                PHARMACEUTICALS, INC.** |
|                               |                                       |                              |
| Date: April                3, 2002 | By:                                   | /s/ Muhammed                Malik |
|                                    |                                                 |
|                                    | Muhammed                Malik, President        |

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