<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  FORM 10-Q/A-2

                                   (Mark One)


     /X/ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
                              EXCHANGE ACT OF 1934

                  For the quarterly period ended March 31, 1999

                                       OR


     / / TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
                              EXCHANGE ACT OF 1934

     For the transition period from __________________ to _________________

                         Commission file number 0-21168


                  CHROMATICS COLOR SCIENCES INTERNATIONAL, INC.
             (Exact Name of Registrant as Specified in Its Charter)


          New York                                     13-3253392
(State or Other Jurisdiction of          (I.R.S. Employer Identification Number)
Incorporation or Organization)


                  5 East 80th Street, New York, New York 10021
                    (Address of principal executive offices)


                                 (212) 717-6544
              (Registrant's Telephone Number, Including Area Code)

              (Former Name, Former Address and Former Fiscal Year,
                          if Changed Since Last Report)

Indicate by check whether the registrant (1) has filed all reports required to
be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes /X/ No / /

                APPLICABLE ONLY TO ISSUERS INVOLVED IN BANKRUPTCY
                  PROCEEDINGS DURING THE PRECEDING FIVE YEARS:

Indicate by check whether the registrant has filed all documents and reports
required to be filed by Section 12, 13 or 15(d) of the Securities Exchange Act
of 1934 subsequent to the distribution of securities under a plan confirmed by
court. Yes / / No / / N/A

<PAGE>

                      APPLICABLE ONLY TO CORPORATE ISSUERS:

Indicate the number of shares outstanding of each of the registrant's classes of
common stock, as of the latest practicable date: 15,535,481.


                                EXPLANATORY NOTE

This Quarterly Report on Form 10-Q/A-2 is being filed to update the signature
page to the Form 10-Q/A for the first quarter ended March 31, 1999 which was
filed with the Securities and Exchange Commission on November 12, 1999. This
Quarterly Report on Form 10-Q/A-2 is being filed to update the signature page to
the Form 10-Q/A for the first quarter ended March 31, 1999 which was filed with
the Securities and Exchange Commission on November 12, 1999.


                                   SIGNATURES

In accordance with the requirements of the Exchange Act, the registrant caused
this report to be signed on its behalf by the undersigned, thereunto duly
authorized.

                  CHROMATICS COLOR SCIENCES INTERNATIONAL, INC.

Date: November 12, 1999                  By: /s/ Darby S. Macfarlane
                                            ---------------------------
                                              Darby S. Macfarlane
                                              Chief Executive Officer

Date: November 12, 1999                  By: /s/ Leslie Foglesong
                                            ------------------------
                                              Leslie Foglesong
                                              Treasurer and Chief Financial
                                              and Principal Accounting Officer