UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549










FORM 10-K/A

(Amendment No. 1)



(Mark One)



xANNUAL
REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934



For the fiscal year ended December 31, 2019 __________________________________________

or



 ̈TRANSITION
REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934



For the transition period from _______________________ to _____________________________



Commission file number 001-37717










SENSEONICS HOLDINGS, INC.



(Exact name of registrant as specified in
its charter)



|DelawareState or other jurisdiction of
incorporation or organization |  | 47-1210911(I.R.S. Employer
Identification No.)
|-------------------------------------------------------------------- |  | ----------------------------------------------










20451 Seneca Meadows Parkway

Germantown, MD 20876-7005

(301) 515-7260

(Address and telephone number, including
area code, of registrant’s principal executive offices)



Securities registered pursuant to Section
12(b) of the Act:



|Title of Each Class:           | Trading Symbol |  | Name of Each Exchange on which Registered
|------------------------------ | -------------- |  | -----------------------------------------
|Common Stock, $0.001 par value | SENS           |  | NYSE American                            



Securities registered pursuant to section
12(g) of the Act:



None



Indicate
by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ̈
     No x



Indicate
by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes ̈ 
     No x



Indicate
by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports),
and (2) has been subject to such filing requirements for the past 90 days. Yesx
     No  ̈



Indicate
by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant
to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that
the registrant was required to submit such files). Yesx     No  ̈





Indicate by check mark whether the registrant is
a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company.
See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,”
and “emerging growth company” in Rule 12b-2 of the Exchange Act.



|Large accelerated filer ̈ |  | Accelerated filerx |  | Non-accelerated filer ̈ |  | Smaller reporting
 companyx |  | Emerging growth company ̈
|------------------------ |  | ------------------ |  | ---------------------- |  | --------------------------- |  | ------------------------



If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for
complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ̈



Indicate
by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes ̈    No x



As of June 28, 2019, the last business day of the
registrant’s last completed second quarter, the aggregate market value of the common stock held by non-affiliates of the
registrant was approximately $216.5 million based on the closing price of the registrant’s common stock, as reported by the
NYSE American on such date.



As of April 20, 2020, 204,548,937 shares of common
stock, $0.001 par value, were outstanding.


















TABLE OF CONTENTS



|              |    |                                                                                                    | Page
|------------- | -- | -------------------------------------------------------------------------------------------------- | ----
|              |    | Explanatory Note                                                                                   | 2   
|              |   
|Part
    III. | 4 
|              |    |                                                                                                   
|Item
    10.  |    | Directors, Executive
    Officers and Corporate Governance                                         | 4   
|Item
    11.  |    | Executive Compensation                                                                             | 7   
|Item
    12.  |    | Security
    Ownership of Certain Beneficial Owners and Management and Related Shareholder Matters | 14  
|Item
    13.  |    | Certain Relationships
    and Related Transactions, and Director Independence                      | 17  
|Item
    14.  |    | Principal Accounting
    Fees and Services                                                         | 19  
|              |   
|Part
    IV.  | 20
|              |    |                                                                                                   
|Item 15.      |    | Exhibits and
    Financial Statement Schedules                                                     | 20  
|              |    |                                                                                                   
|              |    | Signatures                                                                                         | 21  





2







EXPLANATORY NOTE



Senseonics Holdings, Inc. (the
 “Registrant”) is filing this Amendment No. 1 to Annual Report on Form 10-K/A (the “Amendment”) to
amend its Annual
Report on Form 10-K for the year ended December 31, 2019 (File Number 001-37717) (the “Form 10-K”), as filed
with the Securities and Exchange Commission (the “SEC”) on March 16, 2020. The principal purpose of the Amendment
is to include in Part III the information that previously was to be incorporated by reference from the proxy statement for
the Registrant’s 2020 Annual Meeting of Shareholders. This Amendment hereby provides the additional information
required by Part III, Items 10 through 14 of the Form 10-K. In addition, in accordance with Rule 12b-15 under the
Securities Exchange Act of 1934, as amended (the “Exchange Act”), Item 15 of Part IV of the Original Form 10-K
Filing has been amended to include additional exhibits 10.1 to 10.8 as well as new certifications by the Registrant’s
principal executive officer and principal financial officer as exhibits 31.1 and 31.2.



No attempt has been made in this Amendment to modify or update
the other disclosures presented in the Form 10-K. This Amendment does not reflect events occurring after the filing of the Form
10-K or modify or update those disclosures that may be affected by subsequent events. Accordingly, this Amendment should be read
in conjunction with the Form 10-K and the Registrant’s other filings with the SEC.



In this report, unless otherwise indicated or the context otherwise
requires, all references to “Senseonics,” “we,” “us,” “our,” “ours”
and “the Company” or similar terms refer to Senseonics Holdings, Inc. and its subsidiary.





3







PART III



Item 10. Directors, Executive Officers and Corporate Governance



Directors and Executive
Officers



The following table sets forth information concerning our directors
and executive officers, including their ages as of the date hereof. There are no family relationships among any of our directors
or executive officers.



|NAME                           |  | AGE |  | POSITION                                                        
|------------------------------ |  | --- |  | ----------------------------------------------------------------
|Executive Officers:            |  |     |  |                                                                 
|Timothy T. Goodnow, Ph.D.      |  | 58  |  | President, Chief Executive Officer and Director                 
|Francine R. Kaufman, M.D.      |  | 69  |  | Chief Medical Officer and Director                              
|Nick B. Tressler               |  | 47  |  | Chief Financial Officer, Secretary and Treasurer                
|Mukul Jain, Ph.D.              |  | 47  |  | Chief Operating Officer                                         
|Mirasol Panlilio               |  | 55  |  | Vice President and General Manager, Global Commercial Operations
|                               |  |     |  |                                                                 
|Non-Employee Directors:        |  |     |  |                                                                 
|Stephen Edelman, M.D.          |  | 64  |  | Director                                                        
|Edward J. Fiorentio            |  | 61  |  | Director                                                        
|Peter Justin Klein, M.D., J.D. |  | 42  |  | Director                                                        
|Stephen P. DeFalco             |  | 59  |  | Director                                                        
|Douglas S. Prince              |  | 66  |  | Director                                                        
|Douglas A. Roeder              |  | 49  |  | Director                                                        



Executive Officers



Timothy T. Goodnow, Ph.D.



Dr. Goodnow was elected as one of our directors and was appointed
as our President and Chief Executive Officer in December 2015. From 2010 to December 2015, Dr. Goodnow served on the board of directors
of Senseonics, Incorporated and he served as the President and Chief Executive Officer of Senseonics, Incorporated from 2011 to
December 2015. Dr. Goodnow served as Vice President, Technical Operations of Abbott Diabetes Care, a healthcare company, from 2000
to 2011. Prior to that, he held positions at TheraSense, Verax Biomedical, Inc. and Dade Behring and Baxter Healthcare. Dr. Goodnow
received his Ph.D. and B.S. in chemistry from The University of Miami. Our Board of Directors believes that Dr. Goodnow's experience
as our Chief Executive Officer, his background in medical device development and his knowledge of the diabetes industry qualify
him to serve as a director of our company.



Francine R. Kaufman, M.D.



Dr. Kaufman was appointed as one of our directors in November
2019 and was appointed as our Chief Medical Officer in March 2019. Prior to joining our company, Dr. Kaufman served as Chief Medical
Officer and Vice President of Global Clinical, Regulatory and Medical Affairs at Medtronic Diabetes from 2009 to January 2019.
Prior to that, she served as Director of the Comprehensive Childhood Diabetes Center, and head of the Center for Endocrinology,
Diabetes and Metabolism at Children's Hospital Los Angeles from 1991 to 2009. Dr. Kaufman is also a Distinguished Professor Emerita
of Pediatrics and Communications at the Keck School of Medicine and the Annenberg School of Communications of the University of
Southern California. She was formerly the president of the American Diabetes Association in 2003 and chair of the National Diabetes
Education Program from 2008 to 2009. Dr. Kaufman was also elected to the National Academy of Medicine in 2005. She was also an
advisor to the Governor on the California Initiative on Health, Fitness and Obesity in 2007. Dr. Kaufman received her B.A. from
Northwestern University and her M.D. from Chicago Medical School. Our Board of Directors believes that Dr. Kaufman’s experience
as our Chief Medical Officer, her background in medical device development and her medical expertise with diabetes qualify her
to serve as a director of our company.



Nick Tressler



Mr. Tressler was appointed as our Chief Financial Officer in
November 2019 and previously served as our Senior Director, Financial Planning and Analysis since March 2019. Prior to joining
our company, Mr. Tressler served as a strategic and financial consultant for several biopharmaceutical companies from April 2018
to March 2019. Prior to that, Mr. Tressler was the Vice President, Financial Planning and Analysis at Sucampo Pharmaceuticals,
Inc., a public global biopharmaceutical company, from May 2016 to April 2018. Prior to Sucampo, Mr. Tressler was a Site Controller
at AstraZeneca PLC, a public global biopharmaceutical company, from 2013 to May 2016. Mr. Tressler holds a M.B.A. from The Johns
Hopkins University Carey Business School and a B.S. from the University of Maryland College Park Robert H. Smith School of Business.



Mukul Jain, Ph.D.



Dr. Jain was appointed as our Chief Operating Officer in
January 2017. Dr. Jain previously served as our Vice President Operations, Quality and Regulatory from December 2015 to
January 2017. Dr. Jain served as Senior Director, Quality and Regulatory of Senseonics, Incorporated from 2012 to 2014 and as
Vice President Operations, Quality and Regulatory of Senseonics, Incorporated from 2014 to December 2015. Prior to that, Dr.
Jain held various positions at Medtronic, Inc., a medical technology and services company, from 1999 to 2012, most recently
as a senior program manager. Dr. Jain received his M.B.A. from the University of Minnesota, Carlson School of Management, his
Ph.D. in chemical engineering from the University of South Carolina and his B.Tech. from the Indian Institute of Technology,
Kanpur.





4







Mirasol Panlilio



Ms. Panlilio was appointed as our Vice President and General
Manager, Global Commercial Operations in June 2017. Prior to that, Ms. Panlilio served as Vice President, Global Sales and Marketing
from December 2015 to June 2017. Ms. Panlilio served as the Vice President, Global Sales and Marketing of Senseonics, Incorporated
from 2014 to December 2015. Prior to joining Senseonics, Incorporated, Ms. Panlilio served as Vice President, Global Marketing
and Sales at Viveve, Inc. from 2012 to 2014, an Independent Marketing Consultant at MGP Retail Consulting, LLC from 2011 to 2014,
Vice President of Sales and Marketing for Arkal Medical, Inc. from 2010 to 2011 and Vice President of Marketing and Sales at VeraLight,
Inc. from 2007 to 2010. From 2003 to 2007, Ms. Panlilio worked at Abbott Diabetes Care. Ms. Panlilio received her B.S. in business
administration from San Jose State University.



Non-Employee Directors



Steven Edelman, M.D.



Dr. Edelman was elected to our Board of Directors in September
2016. Dr. Edelman has served as a Professor of Medicine in the Division of Endocrinology, Diabetes & Metabolism at the University
of California, San Diego and the Veterans Affairs Healthcare System of San Diego since 2001. He also currently serves as a director
of Taking Control of Your Diabetes, a non-profit organization promoting patient education, motivation and self-advocacy that he
founded in 1995, and the Diabetes Care Clinic VA Medical Center. Dr. Edelman received his B.A. and his M.S. in Biology from the
University of California, Los Angeles and his M.D. from the University of California, Davis. Our Board of Directors believes that
Dr. Edelman's substantial diabetes industry experience qualifies him to serve as a director of our company.



Edward J. Fiorentino



Mr. Fiorentino was elected to our Board of Directors in December
2015. Mr. Fiorentino served on the Senseonics, Incorporated Board of Directors from March 2012 to December 2015. Since March 2016,
Mr. Fiorentino has served as Chairman and Chief Executive Officer of TerSera Therapeutics, a specialty pharmaceutical company.
From 2013 to January 2016, Mr. Fiorentino has served as Chairman and Chief Executive Officer of Crealta Pharmaceuticals, a specialty
pharmaceutical company. From 2009 to 2013, he was the Chief Executive Officer of Actient Pharmaceuticals. Prior to Actient, Mr.
Fiorentino served in various positions at Abbott Laboratories, including Corporate Vice President of Pharmaceutical Commercial
Operations, for more than 20 years. He also previously served as Senior Vice President and President of Abbott Diabetes Care and
was Executive Vice President of TAP Pharmaceuticals. Mr. Fiorentino began his career with Bristol-Myers. Mr. Fiorentino received
his B.S. in Business Administration from the State University of New York and his M.B.A. from Syracuse University. Our Board of
Directors believes that Mr. Fiorentino's substantial healthcare and pharmaceutical experience qualifies him to serve as a director
of our company.



Peter Justin Klein, M.D., J.D.



Dr. Klein was elected to our Board of Directors in December
2015. Dr. Klein served on the Senseonics, Incorporated Board of Directors from 2013 to December 2015. Since December 2018, Dr.
Klein has served as a Managing Director at Vensana Capital Management, LLC. Dr. Klein currently serves as a director of PhaseBio
Pharmaceuticals, Inc. and several private life sciences companies. From 2012 to December 2018, Dr. Klein served as a Partner at
NEA. Prior to joining NEA, Dr. Klein worked for the Duke University Health System. Dr. Klein received his A.B., B.S. and M.D. from
Duke University and his J.D. from Harvard Law School. Our Board of Directors believes that Dr. Klein's significant legal and medical
expertise in healthcare and his services as a venture capital investor and director of multiple biotechnology and medical device
companies qualify him to serve as a director of our company.



Stephen P. DeFalco



Mr. DeFalco was elected as a director and our chairman in December
2015. Mr. DeFalco served as chairman of the Senseonics, Incorporated board of directors from 2010 to December 2015 and served as
Senseonics, Incorporated's interim Chief Executive Officer from 2010 to 2011. In August 2019, Mr. DeFalco became the Chairman and
Chief Executive Officer of Creation Technologies. From April 2018 to August 2019, Mr. DeFalco was a partner at Lindsay Goldberg
 & Co LLC. From 2011 until January 2018, Mr. DeFalco served as the Chief Executive Officer of Crane & Co, Inc., a global
technology company, and also served on its board of directors. Previously, from 2005 to 2010, he served as the Chief Executive
Officer and on the board of directors of Nordion Inc. (formerly MDS Inc.), a public life sciences company. Mr. DeFalco received
his M.B.A. from the Massachusetts Institute of Technology—Sloan School of Management, his M.S.E.E. from Syracuse University
and his B.S.M.E. from the Massachusetts Institute of Technology. Our Board of Directors believes that Mr. DeFalco's leadership,
executive, managerial and business experience with life sciences companies qualifies him to serve as a director of our company.



Douglas S. Prince



Mr. Prince was elected to our Board of Directors in
December 2015. Mr. Prince served on the Senseonics, Incorporated board of directors from February 2015 to December 2015. Mr.
Prince served as the Chief Financial Officer of Crane & Co., Inc., a global technology company, from 2013 to January
2018. From 2010 to 2013, Mr. Prince served as the Chief Financial Officer of Northern Power Systems Corp., an energy
technology company. From 2007 to 2010, Mr. Prince served as Chief Financial Officer of Nordion Inc. (formerly MDS Inc.), a
public life sciences company. Since November 2019, Mr. Prince has also served on the Board of Directors of Creation
Technologies, a private electronics manufacturing services company. Mr. Prince received his B.B.A. in Business Administration
from the University of Kentucky. Our Board of Directors believes that Mr. Prince's executive experience and financial
expertise qualify him to serve as a director of our company.





5







Douglas A. Roeder



Mr. Roeder was elected to our Board of Directors in December
2015. Mr. Roeder served on the Senseonics, Incorporated board of directors from October 2011 to December 2015. Mr. Roeder joined
Delphi Ventures as an Associate in 1998, and has been a Partner of Delphi Ventures since 2000, focusing on medical devices, diagnostics
and biotechnology. Prior to joining Delphi Ventures, Mr. Roeder was an Associate with Alex, Brown & Sons Healthcare Investment
Banking Group. Mr. Roeder currently serves on the boards of directors of Tandem Diabetes, Inc. and several private companies. Mr.
Roeder previously served on the board of directors of TriVascular Technologies, Inc. from 2008 to 2016. Mr. Roeder received his
A.B. from Dartmouth College. Our Board of Directors believes that Mr. Roeder's substantial experience with companies in the healthcare
sector and his venture capital, financial and business experience qualify him to serve as a director of our company.



Audit Committee



Our Audit Committee is composed of three directors: Mr. Prince,
Dr. Klein and Mr. Fiorentino.



Our Board of Directors reviews the NYSE American listing standards
definition of independence for Audit Committee members on an annual basis and has determined that all members of our Audit Committee
are independent (as independence is currently defined in Section 803B of the NYSE American Company Guide and under Rule 10A-3 under
the Exchange Act).



Our Board of Directors has also determined that Mr. Prince qualifies
as an "audit committee financial expert," as defined in applicable SEC rules. Our Board of Directors made a qualitative
assessment of Mr. Prince's level of knowledge and experience based on a number of factors, including his formal education and experience
as a chief financial officer for public reporting companies.



Stockholder Recommendation of
Director Nominees



Our Nominating and Corporate Governance Committee will consider
director candidates recommended by stockholders. Our Nominating and Corporate Governance Committee does not intend to alter the
manner in which it evaluates candidates, including the minimum criteria set forth above, based on whether or not the candidate
was recommended by a stockholder. Stockholders who wish to recommend individuals for consideration by our Nominating and Corporate
Governance Committee to become nominees for election to our Board of Directors may do so by delivering a written recommendation
to our Nominating and Corporate Governance Committee in care of our Corporate Secretary at 20451 Seneca Meadows Parkway, Germantown,
Maryland 20876-7005. Any such recommendation should be delivered at least 90 days, but no more than 120 days, prior to the anniversary
date of the mailing of our proxy statement for the last Annual Meeting of Stockholders. Submissions must include the full name
of the proposed nominee, a description of the proposed nominee's business experience for at least the previous five years, complete
biographical information, a description of the proposed nominee's qualifications as a director and a representation that the nominating
stockholder is a beneficial or record holder of our stock and has been a holder for at least one year. Any such submission must
be accompanied by the written consent of the proposed nominee to be named as a nominee and to serve as a director if elected.



CODE OF ETHICS



We have adopted an Amended and Restated Code of Business Conduct
and Ethics, or the Code of Ethics, applicable to all of our employees, executive officers and directors. The Code of Ethics is
available on our website at www.senseonics.com. Our Audit Committee is responsible for overseeing the Code of Ethics and must approve
any waivers of the Code of Ethics for executive officers and directors. If we make any substantive amendments to the Code of Ethics
or grant any waiver from a provision of the Code of Ethics to any executive officer or director, we will promptly disclose the
amendment or waiver on our website.





6







Item 11. Executive Compensation



For the year ended December 31, 2019, our named executive officers
were:



| | · | Timothy T. Goodnow, Ph.D., our President and Chief Executive Officer;
| | - | ---------------------------------------------------------------------
| | · | Jon D. Isaacson, our former Chief Financial Officer;                 
| | · | Mukul Jain, Ph.D., our Chief Operating Officer; and                  
| | · | Francine R. Kaufman, our Chief Medical Officer.                      



Summary Compensation Table



The following table presents the compensation awarded to, earned
by or paid to each of our named executive officers for the years ended December 31, 2019 and 2018.



|Name and Principal Position           |  | Year |      |  | Salary ($) |  |         | Option Awards ($)(1) |  |  | Non-Equity Incentive Plan Compensation ($)(2) |  |  | All Other
 Compensation ($) |         |  | Total ($) | 
|------------------------------------- |  | ---- | ---- |  | ---------- |  | ------- | -------------------- |  |  | --------------------------------------------- |  |  | --------------------------- | ------- |  | --------- | 
|Timothy T. Goodnow                    |  |      | 2019 |  |            |  | 536,000 |                      |  |  | 1,208,880                                     |  |  |                             | 466,320 |  |           | 
|President and Chief Executive Officer |  |      | 2018 |  |            |  | 536,000 |                      |  |  | 1,273,643                                     |  |  |                             | 361,800 |  |           | 
|Jon D. Isaacson                       |  |      | 2019 |  |            |  | 393,939 |                      |  |  | 921,899                                       |  |  |                             | —       |  |           | 
|Former Chief Financial Officer        |  |      |      |  |            |  |         |                      |  |  |                                               |  |  |                             |         |  |           | 
|Mukul Jain, Ph.D.                     |  |      | 2019 |  |            |  | 414,750 |                      |  |  | 808,439                                       |  |  |                             | 180,416 |  |           | 
|Chief Operating Officer               |  |      | 2018 |  |            |  | 395,000 |                      |  |  | 810,875                                       |  |  |                             | 177,750 |  |           | 
|Francine R. Kaufman, M.D. (4)         |  |      | 2019 |  |            |  | 410,625 |                      |  |  | 1,131,779                                     |  |  |                             | 179,438 |  |           | 
|Chief Medical Officer                 |  |      |      |  |            |  |         |                      |  |  |                                               |  |  |                             |         |  |           | 










|(1) | The amounts shown in this column do not reflect dollar amounts actually received by our named executive officers. Instead,
these amounts include the full grant date fair value for awards granted during the indicated year. The grant date fair value was
computed in accordance with Financial Accounting Standard Board Accounting Standards Codification Topic 718, or ASC Topic 718,
Compensation—Stock Compensation. Unlike the calculations contained in our audited consolidated financial statements,
this calculation does not give effect to any estimate of forfeitures related to service-based vesting, but assumes that the executive
will perform the requisite service for the award to vest in full. The assumptions we used in valuing options are described in Note
12 to our audited consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31,
2019.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|(2) | The amounts reflect bonus paid on the achievement of specified corporate goals, as discussed further below under "—Narrative
to Summary Compensation Table—Annual Bonus."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|(3) | The amounts reflect severance payments accrued for Mr. Isaacson during 2019. Mr. Isaacson served as our Chief Financial Officer
from January 7, 2019 to November 15, 2019 and continued providing services to us in an advisory capacity to support a transition
of responsibilities through December 31, 2019. In connection with Mr. Isaacson's departure, we entered into a Severance Agreement
and Release with Mr. Isaacson, pursuant to which we agreed Mr. Isaacson would receive his then current base salary through the
transition period and, following the transition period, would be eligible to receive severance payments equal to continued payment
of his base salary for six months, healthcare continuation coverage through June 30, 2020, and an additional payment of $100,000
representing approximately half of Mr. Isaacson’s target bonus in 2019.                                                
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|(4) | Dr. Kaufman joined as our Chief Medical Officer on March 4, 2019.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            





7









Narrative to Summary Compensation
Table



We review compensation annually for all employees, including
our named executive officers. In setting executive base salaries and bonuses and granting equity incentive awards, we consider
compensation for comparable positions in the market, the historical compensation levels of our executives, individual performance
as compared to our expectations and objectives, our desire to motivate our employees to achieve short- and long-term results that
are in the best interests of our stockholders, and a long-term commitment to our company. We do not target a specific competitive
position or a specific mix of compensation among base salary, bonus or long-term incentives.



Our Compensation Committee has historically determined our executives'
compensation. Our Compensation Committee typically reviews and discusses management's proposed compensation with the chief executive
officer for all executives other than the chief executive officer. Based on those discussions and its discretion, our Compensation
Committee then approves the compensation of each executive officer after discussions without members of management present.



Our Compensation Committee has engaged Willis Towers Watson,
a compensation consultant, and reviewed Willis Towers Watson's compensation data for executives at similarly sized medical device
companies when determining executive compensation.



Annual Base Salary



We have entered into employment agreements with each of our
named executive officers that established their initial base salaries and target bonus opportunities. These base salaries are reviewed
periodically by our Compensation Committee. The following table presents the annual base salaries for each of our named executive
officers for 2018, 2019 and 2020. The 2018 base salaries for Drs. Goodnow and Jain became effective on January 1, 2018, the 2019
base salaries became effective on January 1, 2019, and the 2020 base salaries became effective on January 1, 2020. Mr. Isaacson
and Dr. Kaufman joined our company on January 7, 2019 and March 4, 2019, respectively, but the amounts included in the table below
reflect each named executive officer’s annualized base salary for 2019.



|Name                   |  | 2018 Base Salary ($) |         |  | 2019 Base Salary ($) |  |         | 2020 Base Salary ($) | 
|---------------------- |  | -------------------- | ------- |  | -------------------- |  | ------- | -------------------- | 
|Timothy T. Goodnow     |  |                      | 536,000 |  |                      |  | 536,000 |                      | 
|Jon D. Isaacson(1)     |  |                      | —       |  |                      |  | 400,000 |                      | 
|Mukul Jain             |  |                      | 395,000 |  |                      |  | 414,750 |                      | 
|Francine R. Kaufman(2) |  |                      |         |  |                      |  | 495,000 |                      | 










|(1) | Mr. Isaacson served as our Chief Financial Officer from
January 7, 2019 to November 15, 2019. Accordingly, this table does not include a 2018 or 2020 base salary for Mr. Isaacson.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|    |                                                                                                                                                                                    

|(2) | Dr. Kaufman joined as our Chief Medical Officer on March
4, 2019. Accordingly, this table does not include a 2018 base salary for Dr. Kaufman.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------



Annual Bonus



We seek to motivate and reward our executives for achievements
relative to our corporate goals and expectations for each fiscal year. Each named executive officer has a target bonus opportunity,
defined as a percentage of his or her annual salary. The following table presents the annual target bonus opportunity, as a percentage
of annual base salary, for each of our named executive officers for 2018, 2019 and 2020.



|Name                   |  | Target Bonus (as a % of Base Salary) (%) 2018 |    |  | Target Bonus (as a % of Base Salary) (%) 2019 |  |     | Target Bonus (as a % of Base Salary) (%) 2020 | 
|---------------------- |  | --------------------------------------------- | -- |  | --------------------------------------------- |  | --- | --------------------------------------------- | 
|Timothy T. Goodnow     |  |                                               | 75 |  |                                               |  | 100 |                                               | 
|Jon D. Isaacson(1)     |  |                                               |    |  |                                               |  | 50  |                                               | 
|Mukul Jain             |  |                                               | 50 |  |                                               |  | 50  |                                               | 
|Francine R. Kaufman(2) |  |                                               |    |  |                                               |  | 50  |                                               | 



|(1) | Mr. Isaacson served as our Chief Financial Officer from January 7, 2019 to November 15, 2019. Accordingly, this table does
not include a 2018 or 2020 target bonus for Mr. Isaacson.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|    |                                                                                                                                                                                     

|(2) | Dr. Kaufman joined as our Chief Medical Officer on March
4, 2019. Accordingly, this table does not include a 2018 target bonus for Dr. Kaufman.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------





8







For 2018, bonuses were based on our
achievement of specified corporate goals, including achieving specified revenue and expense targets, initiation of the U.S. 180-day
sensor pivotal trial and successful completion of quality audits. Based on the level of achievement, our compensation committee
awarded each of Dr. Goodnow and Dr. Jain 90% of their target bonuses based on their respective 2018 base salaries.



For 2019, bonuses were based on our
achievement of specified corporate goals, including achieving specified revenue targets, achieving specified customer retention
targets, achieving specified payor coverage targets, completion of all patient visits in our U.S. 180-day sensor pivotal trial,
achieving a cost of goods sold target for sensor kits and achieving specified quality targets. Based on the level of achievement,
our compensation committee awarded each of Drs. Goodnow and Jain 87% of their target bonuses based on their respective 2019 base
salaries. Dr. Kaufman also received 87% of her target bonus, pro-rated based on her start date in 2019.



These actual bonus amounts are reflected in the "Non-Equity
Incentive Plan Compensation" column of the Summary Compensation Table above.



Long-Term Incentives



Our 1997 stock option plan, or the 1997 plan, authorized us,
and the amended and restated 2015 equity incentive plan, or the 2015 plan, authorizes us to make grants to eligible recipients
of non-qualified stock options and incentive stock options.



We award stock options on the date our Compensation Committee
approves the grant. We set the option exercise price equal to 100% of the per-share fair market value of our common stock on the
date of grant.



In February 2018, our Compensation Committee awarded to Drs.
Goodnow and Jain options to purchase 777,797 and 495,191 shares of our common stock, respectively. Each of these options was issued
with an exercise price of $2.62 per share. The shares underlying the options granted to Drs. Goodnow and Jain vest in 48 equal
monthly installments, subject to the named executive officer’s continued service through each applicable vesting date. All
shares subject to vesting under these option grants will vest in full and become immediately exercisable upon the closing of a
change in control of our company.





9







In January 2019, our Compensation Committee awarded to Drs.
Goodnow and Jain options to purchase 800,000 and 535,000 shares of our common stock, respectively. Each of these options was issued
with an exercise price of $2.72 per share. The shares underlying the options granted to Drs. Goodnow and Jain vest in 48 equal
monthly installments, subject to the named executive officer’s continued service through each applicable vesting date. All
shares subject to vesting under these option grants will vest in full and become immediately exercisable upon the closing of a
change in control of our company.



In January 2019, our Compensation Committee awarded to Mr. Isaacson
an option to purchase 550,000 shares of our common stock. The option was issued with an exercise price of $2.84 per share. The
option was terminated in connection with the departure of Mr. Isaacson prior to any portion of the shares vesting.



In March 2019, our Compensation Committee awarded to Dr. Kaufman
an option to purchase 550,000 shares of our common stock. The option was issued with an exercise price of $3.07 per share. The
shares underlying the option granted to Dr. Kaufman vest in 48 equal monthly installments, subject to Dr. Kaufman’s continued
service through each applicable vesting date. All shares subject to vesting under this option grant will vest in full and become
immediately exercisable upon the closing of a change in control of our company.



Outstanding Equity Awards at
End of 2019



The following table provides information about outstanding options
held by each of our named executive officers at December 31, 2019. All of these options were granted under the 1997 plan or the
2015 plan. None of our named executive officers held any other stock awards as of December 31, 2019.





|Name               |  | Number of Securities Underlying Unexercised Options (#) Exercisable |               |  | Number of Securities Underlying Unexercised Options (#) Unexercisable |  |                | Option Exercise Price ($) |  |  | Option Expiration Date
|------------------ |  | ------------------------------------------------------------------- | ------------- |  | --------------------------------------------------------------------- |  | -------------- | ------------------------- |  |  | ----------------------
|Timothy T. Goodnow |  |                                                                     | 2,038,610 (1) |  |                                                                       |  | —              |                           |  |  | 0.54                  
|                   |  |                                                                     | 589,093 (1)   |  |                                                                       |  | —              |                           |  |  | 0.54                  
|                   |  |                                                                     | 237,046       |  |                                                                       |  | —              |                           |  |  | 0.54                  
|                   |  |                                                                     | 173,113       |  |                                                                       |  | —              |                           |  |  | 1.95                  
|                   |  |                                                                     | 318,681       |  |                                                                       |  | 28,971 (3)(7)  |                           |  |  | 2.97                  
|                   |  |                                                                     | 546,875       |  |                                                                       |  | 203,125 (4)(7) |                           |  |  | 2.74                  
|                   |  |                                                                     | 356,490       |  |                                                                       |  | 421,307 (5)(7) |                           |  |  | 2.62                  
|                   |  |                                                                     | 183,333       |  |                                                                       |  | 616,667 (6)(7) |                           |  |  | 2.72                  
|Jon D. Isaacson    |  |                                                                     | —             |  |                                                                       |  | 550,000 (2)    |                           |  |  | 2.84                  
|Mukul Jain         |  |                                                                     | 153,774       |  |                                                                       |  | —              |                           |  |  | 0.46                  
|                   |  |                                                                     | 255,599       |  |                                                                       |  | —              |                           |  |  | 0.54                  
|                   |  |                                                                     | 108,686       |  |                                                                       |  | —              |                           |  |  | 0.54                  
|                   |  |                                                                     | 134,239       |  |                                                                       |  | —              |                           |  |  | 1.95                  
|                   |  |                                                                     | 133,149       |  |                                                                       |  | 12,105 (3)(7)  |                           |  |  | 2.97                  
|                   |  |                                                                     | 229,113       |  |                                                                       |  | 85,099 (4)(7)  |                           |  |  | 2.73                  
|                   |  |                                                                     | 226,962       |  |                                                                       |  | 268,229 (5)(7) |                           |  |  | 2.62                  
|                   |  |                                                                     | 122,604       |  |                                                                       |  | 412,396 (6)(7) |                           |  |  | 2.72                  
|Francine R Kaufman |  |                                                                     | —             |  |                                                                       |  | 550,000 (7)(8) |                           |  |  | 3.07                  










|(1) | In March 2020, Dr. Goodnow exercised a portion of these options with respect to an aggregate of 160,000 shares pursuant to
a trading plan adopted pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, which trading plan provided for the periodic
exercises of these options in full over their respective remaining terms, as the options would expire worthless if not exercised
by their respective expiration dates. After the March 2020 exercises, Dr. Goodnow voluntarily agreed to forfeit the remainder of
these options and terminated the related Rule 10b5-1 plan. Accordingly, these options are no longer outstanding as of the date
of hereof.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | One-fourth of the shares underlying this option were scheduled to vest on January 7, 2020 and the remaining shares were scheduled
to vest in 36 equal monthly installments thereafter, subject to Mr. Isaacson’s continued service through each applicable
vesting date. However, Mr. Isaacson ceased serving as our Chief Financial Officer on November 15, 2019. Thereafter, Mr. Isaacson
continued providing services to us in an advisory capacity to support a transition of responsibilities until December 31, 2019.
Accordingly, this option ceased vesting on December 31, 2019, at which point no shares were vested. Subsequent to December 31,
2019, the option expired in accordance with its terms.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------





10







|(3) | The remaining unvested shares underlying this option vest in 4 equal monthly installments, subject to the officer's continued
service through each applicable vesting date.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | The remaining unvested shares underlying this option vest in 13 equal monthly installments, subject to the officer's continued
service through each applicable vesting date.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(5) | The remaining unvested shares underlying this option vest in 26 equal monthly installments, subject to the officer's continued
service through each applicable vesting date.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(6) | The remaining unvested shares underlying this option vest in 37 equal monthly installments, subject to the officer's continued
service through each applicable vesting date.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(7) | The shares subject to these options will become immediately vested and exercisable in certain circumstances related to a change
in control of our company. See “Narrative to Summary Compensation Table—Long-Term Incentives” above and "—Employment
Agreements, Severance and Change in Control Arrangements" below.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(8) | One-fourth of the shares underlying this option vest on March 4, 2020 and the remaining shares vest in 36 equal monthly installments
thereafter, subject to Dr. Kaufman’s continued service through each applicable vesting date.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Employment Agreements, Severance
and Change in Control Arrangements



Below are descriptions of employment agreements that our named
executive officers entered into with us or Senseonics, Incorporated.



Agreement with Dr. Goodnow



In July 2015, Senseonics, Incorporated entered into an amended
and restated employment agreement with Dr. Goodnow that governs the terms of his employment with us. Pursuant to the agreement,
Dr. Goodnow was originally entitled to an annual base salary of $365,791 and was originally eligible to receive an annual performance
bonus of up to 50% of his base salary, as determined by our Board of Directors. If Dr. Goodnow's employment is terminated by us
without “cause” or if he resigns for “good reason” (each as defined in his employment agreement), he would
be entitled to receive severance payments equal to continued payment of his base salary for 18 months, 100% of his target bonus,
healthcare continuation coverage for up to 18 months, and reimbursement of expenses owed to him through the date of his termination.
If Dr. Goodnow's employment is terminated by us without cause or if he resigns for good reason, coincident with a change in control
(as defined in his employment agreement), he would be entitled to the benefits described above, although he would be entitled to
150%, rather than 100%, of his target bonus, and 50% of his then unvested equity awards would become fully vested. Additionally,
if Dr. Goodnow's employment is terminated by us or any successor entity without cause within 12 months following a change in control,
then 100% of his then unvested equity awards shall become fully vested. Additionally, all of the options granted to Dr. Goodnow
prior to our public offering in March 2016 will become fully vested upon a change in control.



Agreement with Dr. Jain



In July 2015, Senseonics, Incorporated entered into an amended
and restated employment agreement with Dr. Jain, which was subsequently amended in April 2018, that governs the terms of his employment
with us. Pursuant to the agreement as amended, Dr. Jain is entitled to an annual base salary of $376,000 subject to review and
adjustment by our Board of Directors and is eligible to receive an annual performance bonus of up to 50% of his base salary, as
determined by our Board of Directors. If Dr. Jain's employment is terminated by us without “cause” or if he resigns
for “good reason” (each as defined in his employment agreement), he would be entitled to receive severance payments
equal to continued payment of his base salary for one year, a prorated portion of his target bonus for the year in which his service
is terminated, healthcare continuation coverage for up to one year, and reimbursement of expenses owed to him through the date
of his termination. If Dr. Jain's employment is terminated by us without cause or if he resigns for good reason, coincident with
a change in control (as defined in his employment agreement), he would be entitled to the benefits described above, although in
lieu of the bonus described above, he would be entitled to 125% of his target bonus, and 50% of his then unvested equity awards
would become fully vested. Additionally, if Dr. Jain's employment is terminated by us or any successor entity without cause within
12 months following a change in control, then 100% of his then unvested equity awards would become fully vested. Additionally,
all of the options granted to Dr. Jain prior to our public offering in March 2016 will become fully vested upon a change in control.



Agreements with Mr. Isaacson



In January 2019, Senseonics, Incorporated entered into an employment
agreement with Mr. Isaacson that governed the terms of his employment with us. Pursuant to the terms of his employment agreement, Mr. Isaacson was
entitled to an annual base salary of $400,000 and was eligible to receive an annual performance bonus of up to 50% of his annual
base salary based upon our board of directors’ assessment of Mr. Isaacson’s performance and our attainment of
targeted goals as set by our Board of Directors in their sole discretion.   Pursuant to his employment agreement, Mr. Isaacson
also entered into an ideas, inventions, competition and confidentiality agreement with us.





11







In
connection with Mr. Isaacson’s departure, on November 12, 2019, we and Mr. Isaacson entered into a Severance
Agreement and Release. In connection with his separation,Mr. Isaacson continued providing services to us in an advisory
capacity to support a transition of responsibilities until December 31, 2019. The
Severance Agreement and Release provided that Mr. Isaacson would continue to receive his base salary through the transition
period and, following the transition period, would be eligible to receive severance payments equal to continued payment of his
base salary for six months, healthcare continuance coverage through June 30, 2020, and a payment of $100,000 representing
approximately half of Mr. Isaacson’s target bonus in 2019. The Severance Agreement and Release contained a release and
certain restrictive covenants that are binding upon Mr. Isaacson.



Agreement with Dr. Kaufman



In March 2019, Senseonics, Incorporated entered into an employment
agreement with Dr. Kaufman that governs the terms of her employment with us. Pursuant to the agreement, Dr. Kaufman is entitled
to an annual base salary of $495,000 subject to review and adjustment by our Board of Directors and is eligible to receive an annual
performance bonus of up to 50% of her base salary, as determined by our Board of Directors. If Dr. Kaufman’s employment is
terminated by us without “cause” or if she resigns for “good reason” (each as defined in her employment
agreement), she would be entitled to receive severance payments equal to continued payment of her base salary for nine months,
a prorated portion of her target bonus for the year in which her service is terminated, healthcare continuation coverage for up
to one year, and reimbursement of expenses owed to her through the date of her termination. If Dr. Kaufman’s employment is
terminated by us without cause or if she resigns for good reason, coincident with a change in control (as defined in her employment
agreement), she would be entitled to the benefits described above, although in lieu of the bonus described above, she would be
entitled severance payments equal to continued payment of her base salary for one year and she would be entitled to 125% of her
target bonus. Additionally, if Dr. Kaufman’s employment is terminated by us or any successor entity without cause within
12 months following a change in control, then 100% of her then unvested equity awards would become fully vested.



401(k) Plan



We maintain a defined contribution employee retirement plan
for our employees. Our 401(k) plan is intended to qualify as a tax-qualified plan under Section 401 of the U.S. Internal Revenue
Code of 1986, as amended, so that contributions to our 401(k) plan, and income earned on such contributions, are not taxable to
participants until withdrawn or distributed from the 401(k) plan. Our 401(k) plan provides that each participant may contribute
a portion of his or her pre-tax compensation, up to the statutory limit. Under our 401(k) plan, each employee is fully vested in
his or her deferred salary contributions. Employee contributions are held and invested by the plan's trustee, subject to participants'
ability to give investment directions by following specified procedures. We currently make up to a 1% discretionary contribution
or matching contribution to our 401(k) plan.



Non-Employee Director Compensation



In February 2016, our Board of Directors approved a non-employee
director compensation policy which became effective upon the completion of our 2016 public offering. Under this non-employee director
compensation policy, we pay each of our non-employee directors a cash retainer for service on our Board of Directors and for service
on each committee on which the director is a member. The chairman of each committee receives a higher retainer for such service.
These retainers are payable in arrears in four equal quarterly installments on the last day of each quarter, provided that the
amount of such payment is prorated for any portion of such quarter that the director is not serving on our Board of Directors.
No retainers were paid in respect of any period prior to the completion of our 2016 public offering. In October 2018, we amended
our non-employee director compensation policy to increase the annual service retainers, based upon market data of comparable companies
and recommendations presented by Willis Towers Watson. The retainers paid to non-employee directors for service on our Board of
Directors and for service on each committee of our Board of Directors on which the director is a member are as follows:



|                                              |  | Member Annual Service Retainer |        |  | Chairman Additional Annual Service Retainer |  
|--------------------------------------------- |  | ------------------------------ | ------ |  | ------------------------------------------- | -
|Board of Directors                            |  | $                              | 37,500 |  |                                             | $
|Audit Committee                               |  |                                | 7,500  |  |                                             |  
|Compensation Committee                        |  |                                | 6,000  |  |                                             |  
|Nominating and Corporate Governance Committee |  |                                | 4,000  |  |                                             |  



Our non-employee director compensation policy permits
non-employee directors to elect to receive all or a portion of the annual cash compensation in the form of shares of our
common stock. In addition, under our non-employee director compensation policy, each non-employee director elected to our
Board of Directors will receive an option to purchase shares of common stock with an aggregate Black-Scholes option value of
$212,500. The shares subject to each such stock option will vest monthly over a three year period, subject to the
non-employee director's continued service as a director through each applicable vesting date. Further, on the date of each
annual meeting of stockholders each non-employee director that continues to serve as a non-employee member on our Board of
Directors will receive an option to purchase shares of common stock with an aggregate Black-Scholes option value of $106,500.
The shares subject to each such stock option will vest on the one year anniversary of the grant date, subject to the
director's continued service as a non-employee director through each applicable vesting date. The exercise price of these
options will equal the fair market value of our common stock on the date of grant. This policy is intended to provide a total
compensation package that enables us to attract and retain qualified and experienced individuals to serve as directors and to
align our directors' interests with those of our stockholders.





12







Director Compensation Table



The following table sets forth information regarding compensation
earned during the year ended December 31, 2019 by our non-employee directors for service on our Board of Directors from January
1, 2019 to December 31, 2019. Timothy T. Goodnow, our President and Chief Executive Officer, and Francine R. Kaufman, our Chief
Medical Officer, also served on our Board of Directors, but did not receive any additional compensation for their service as directors
and therefore are not included in the table below. The compensation of Drs. Goodnow and Kaufman as named executive officers is
set forth above under "Executive Compensation—Summary Compensation Table."



|Name                    |  | Fees Earned or Paid in Cash(1) ($) |        |  | Option Awards(2) ($) |  |         | Total ($) | 
|----------------------- |  | ---------------------------------- | ------ |  | -------------------- |  | ------- | --------- | 
|Stephen P. DeFalco(3)   |  |                                    | 75,125 |  |                      |  | 106,500 |           | 
|M. James Barrett(4)     |  |                                    | 20,750 |  |                      |  | 106,500 |           | 
|Edward J. Fiorentino(5) |  |                                    | 51,000 |  |                      |  | 106,500 |           | 
|Justin Klein(3)         |  |                                    | 51,000 |  |                      |  | 106,500 |           | 
|Douglas S. Prince(5)    |  |                                    | 60,250 |  |                      |  | 106,500 |           | 
|Douglas A. Roeder(3)    |  |                                    | 54,100 |  |                      |  | 106,500 |           | 
|Steven Edelman(6)       |  |                                    | 47,500 |  |                      |  | 106,500 |           | 










|(1) | In 2019, we granted Messrs. DeFalco, Fiorentino, Klein, Prince and Edelman fully vested restricted stock units covering an
aggregate of 59,579, 39,798, 19,898, 23,482 and 37,085 shares of common stock, respectively, in lieu of aggregate quarterly retainer
fees of $78,249, $51,624, $25,811, $30,434 and $48,123, respectively.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | The amounts in this column do not reflect dollar amounts actually received by our named executive officers. Instead, these
amounts reflect the full grant date fair value for stock options granted during the year as measured pursuant to ASC Topic 718
as stock-based compensation in our consolidated financial statements. Unlike the calculations contained in our consolidated financial
statements, this calculation does not give effect to any estimate of forfeitures related to service-based vesting but assumes that
the director will perform the requisite service for the award to vest in full. The assumptions we used in valuing stock awards
are described in Note 12 to our audited consolidated financial statements included in our Annual Report on Form 10-K for the year
ended December 31, 2019.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | As of December 31, 2019, this director held options to purchase 321,223 shares of our common stock.
|--- | ---------------------------------------------------------------------------------------------------



|(4) | Dr. Barrett resigned from our Board of Directors effective June 30, 2019. As of December 31, 2019, Dr. Barrett held no options
to purchase shares of our common stock.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(5) | As of December 31, 2019, this director held options to purchase 405,123 shares of our common stock.
|--- | ---------------------------------------------------------------------------------------------------



|(6) | As of December 31, 2019, this director held options to purchase 361,193 shares of our common stock.
|--- | ---------------------------------------------------------------------------------------------------



13







Item 12. Security Ownership of Certain Beneficial Owners
and Management and Related Shareholder Matters



Security Ownership
of Certain Beneficial Owners and Management



The following table sets forth certain information regarding
the ownership of our common stock as of March 31, 2020 by (i) each director; (ii) each of our named executive officers; (iii) all
currently serving executive officers and directors as a group; and (iv) all those known by us to be beneficial owners of more than
five percent of our common stock. Except as otherwise noted below, the address for persons listed in the table is c/o Senseonics
Holdings, Inc., 20451 Seneca Meadows Parkway, Germantown, MD 20876.



This table is based upon information supplied by our named executive
officers, directors and principal stockholders and a review of Schedule 13G and Schedule 13D and Section 16 filings with the SEC.
Unless otherwise indicated in the footnotes to the table and subject to common property laws where applicable, we believe that
each stockholder named in the table has sole voting and investment power with regard to the shares indicated as being beneficially
owned. Applicable percentages are based on 204,448,191 shares of common stock outstanding as of March 31, 2020, adjusted as required
by the rules promulgated by the SEC.



|Name of Beneficial Owner                                                 |  | Number of Shares Beneficially Owned |            |  | Percentage of Shares Beneficially Owned | 
|------------------------------------------------------------------------ |  | ----------------------------------- | ---------- |  | --------------------------------------- | 
|Principal Stockholders:                                                  |  |                                     |            |  |                                         | 
|Entities affiliated with New Enterprise Associates, Inc.(1)              |  |                                     | 31,727,449 |  |                                         | 
|Roche Finance Ltd.(2)                                                    |  |                                     | 29,319,010 |  |                                         | 
|Entities affiliated with Robert J. Smith(3)                              |  |                                     | 19,716,139 |  |                                         | 
|Gilder, Gagnon, Howe & Co. LLC(4)                                        |  |                                     | 15,780,806 |  |                                         | 
|Entities affiliated with Wellington Management Group LLP(5)              |  |                                     | 13,357,466 |  |                                         | 
|Entities affiliated with Highbridge Capital Management, LLC(6)           |  |                                     | 17,424,243 |  |                                         | 
|Soros Fund Management LLC(7)                                             |  |                                     | 10,916,666 |  |                                         | 
|Named Executive Officers and Directors:                                  |  |                                     |            |  |                                         | 
|Timothy T. Goodnow, Ph.D.(8)                                             |  |                                     | 4,991,704  |  |                                         | 
|Francine R. Kaufman, M.D.(9)                                             |  |                                     | 160,416    |  |                                         | 
|Mukul Jain, Ph.D.(10)                                                    |  |                                     | 1,519,235  |  |                                         | 
|Jon D. Isaacson                                                          |  |                                     |            |  |                                         | 
|Peter Justin Klein, M.D., J.D.(11)                                       |  |                                     | 366,336    |  |                                         | 
|Stephen P. DeFalco(12)                                                   |  |                                     | 1,108,282  |  |                                         | 
|Edward J. Fiorentino(13)                                                 |  |                                     | 467,345    |  |                                         | 
|Douglas S. Prince(14)                                                    |  |                                     | 436,837    |  |                                         | 
|Douglas A. Roeder(15)                                                    |  |                                     | 10,401,810 |  |                                         | 
|Steven Edelman, M.D.(16)                                                 |  |                                     | 417,197    |  |                                         | 
|All current directors and executive officers as a group (11 persons)(17) |  |                                     | 21,051,011 |  |                                         | 










*Represents beneficial ownership of less than 1%.





14









| | (1)  | Consists
                                         of (a) 20,957,092 shares of common stock and 1,079,435 shares of common stock underlying
                                         immediately exercisable warrants held by New Enterprise Associates 10, Limited Partnership,
                                         or NEA 10, and (b) 8,949,292 shares of common stock and 701,630 shares of common stock
                                         underlying immediately exercisable warrants held by New Enterprise Associates 9, Limited
                                         Partnership, or NEA 9. The shares held by NEA 10 are indirectly held by NEA Partners
                                         10, Limited Partnership, or Partners 10, the sole general partner of NEA 10. The individual
                                         general partners of Partners 10, or NEA 10 GPs, are Peter J. Barris, Scott D. Sandell
                                         and M. James Barrett. Partners 10 and the NEA 10 GPs may be deemed to share voting and
                                         dispositive power over, and be the indirect beneficial owners of, the shares held by
                                         NEA 10. The shares held by NEA 9 are indirectly held by NEA Partners 9, Limited Partnership,
                                         or Partners 9, the sole general partner of NEA 9. The individual general partner of Partners
                                         9 is Peter J. Barris. Partners 9 and Peter J. Barris may be deemed to share voting and
                                         dispositive power over, and be the indirect beneficial owners of, the shares held by
                                         NEA 9. This information has been obtained from a Schedule 13D/A filed on December 12,
                                         2017 by NEA 10, NEA 9, Partners 10, Partners 9, M. James Barrett, Peter J. Barris and
                                         Scott D. Sandell and from Schedule 13D/A filed on June 9, 2017 by NEA 10, NEA 9, NEA
                                         VII, Partners 10, Partners 9, Partners VII, M. James Barrett, Peter J. Barris and Scott
                                         D. Sandell. The principal business address of NEA 10 and NEA 9 is 1954 Greenspring Drive,
                                         Suite 600, Timonium, MD 21093.
| | ---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (2)  | Consists
                                         of 28,345,276 shares of common stock and 973,734 shares of common stock underlying immediately
                                         exercisable warrants held by Roche Finance Ltd. Roche Finance Ltd is a wholly-owned subsidiary
                                         of Roche Holding Ltd, a publicly-held corporation. This information has been obtained
                                         from a Schedule 13D/A filed on March 20, 2019 by Roche Holding Ltd and Roche Finance
                                         Ltd. The principal business address of Roche Finance Ltd is Grenzacherstrasse 122, 4070
                                         Basel, Switzerland.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (3)  | Consists
                                         of 19,636,139 shares of common stock held by Energy Capital, LLC and 80,000 shares of
                                         common stock held by Plato & Associates, LLC. Robert L. Smith, the sole Managing
                                         Member of Energy Capital, LLC and Plato & Associates, LLC, may be deemed to have
                                         voting and dispositive power over the shares held by Energy Capital, LLC and Plato &
                                         Associates, LLC. This information has been obtained from a Schedule 13D/A filed on January
                                         28, 2020 by Robert J. Smith, Energy Capital, LLC and Plato & Associates, LLC. The
                                         address of Robert J. Smith, Energy Capital, LLC and Plato & Associates, LLC is 13650
                                         Fiddlesticks Blvd., Suite 202-324, Ft. Myers, FL 33912.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (4)  | Consists
                                         of 15,780,806 shares of common stock held in customer accounts over which partners and/or
                                         employees of Gilder, Gagnon, Howe & Co. LLC have discretionary authority to dispose
                                         of or direct the disposition of the shares. This information has been obtained from a
                                         Schedule 13G/A filed on February 14, 2020 by Gilder, Gagnon, Howe & Co. LLC. The
                                         principal business address of Gilder, Gagnon, Howe & Co. LLC is 475 10th Avenue New
                                         York, New York 10018.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (5)  | Consists
                                         of 13,357,466 shares of common stock owned of record by clients of Wellington Investment
                                         Advisors. Wellington Investment Advisors Holdings LLP controls directly, or indirectly
                                         through Wellington Management Global Holdings, Ltd., the Wellington Investment Advisors.
                                         Wellington Investment Advisors Holdings LLP is owned by Wellington Group Holdings LLP,
                                         which is owned by Wellington Management Group LLP. This information has been obtained
                                         from a Schedule 13G filed on February 14, 2020 by Wellington Management Group LLP, Wellington
                                         Group Holdings LLP, Wellington Investment Advisors Holdings LLP, and Wellington Management
                                         Company LLP. The principal business address of Wellington Management Company LLP and
                                         its affiliates is 280 Congress Street, Boston, MA 02210.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (6)  | Consists
                                         of 17,424,243 shares of common stock issuable upon the conversion of convertible notes
                                         held by Highbridge Tactical Credit Master Fund, L.P. Highbridge Capital Management, LLC
                                         is the trading manager of Highbridge Tactical Credit Master Fund, L.P. The principal
                                         business address of Highbridge Capital Management, LLC and Highbridge Tactical Credit
                                         Master Fund, L.P. is 227 Park Avenue, 23rd Floor, New York, New York 10172.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (7)  | Consists
                                         of 10,916,666 shares of common stock issuable upon the conversion of convertible notes
                                         held in customer accounts, including the account of Quantum Partners, LP. Soros Fund
                                         Management LLC serves as the investment manager for Quantum Partners, LP and the other
                                         customer account and has investment discretion over the securities. George Soros serves
                                         as the Chairman of Soros Fund Management LLC and has sole discretion to replace FPR Manager
                                         LLC, the Manager of Soros Fund Management LLC. This information has been obtained from
                                         a Schedule 13G filed on February 21, 2020 by Soros Fund Management LLC and George Soros.
                                         The principal business address of Soros Fund Management LLC and its affiliates is 250
                                         West 55th Street, 29th Floor, New York, New York 10019.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (8)  | Consists
                                         of (a) 437,012 shares of common stock and (b) 4,554,692 shares of common stock underlying
                                         options that are exercisable within 60 days of March 31, 2020.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (9)  | Consists
                                         of shares of common stock underlying options that are exercisable within 60 days of March
                                         31, 2019.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (10) | Consists
                                         of (a) 2,962 shares of common stock and (b) 1,516,273 shares of common stock underlying
                                         options that are exercisable within 60 days of March 31, 2020.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  





15







| | (11) | Consists
                                         of (a) 42,322 shares of common stock and (b) 324,014 shares of common stock underlying
                                         options that are exercisable within 60 days of March 31, 2020.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
| | ---- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | (12) | Consists
                                         of (a) 787,059 shares of common stock and (b) 321,223 shares of common stock underlying
                                         options that are exercisable within 60 days of March 31, 2020.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | (13) | Consists
                                         of (a) 62,222 shares of common stock and (b) 405,123 shares of common stock underlying
                                         options that are exercisable within 60 days of March 31, 2020.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | (14) | Consists
                                         of (a) 31,714 shares of common stock and (b) 405,123 shares of common stock underlying
                                         options that are exercisable within 60 days of March 31, 2020.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | (15) | Consists
                                         of (a) 9,751,725 shares of common stock held by Delphi Ventures VIII, L.P,, or Delphi
                                         VIII, (b) 94,569 shares of common stock held by Delphi BioInvestments VIII, L.P., or
                                         Delphi Bio, and (c) 321,223 shares of common stock underlying options that are held by
                                         Douglas Roeder and are exercisable within 60 days of March 31, 2020. Delphi Management
                                         Partners VIII, L.L.C., or DMP VIII, is the general partner of each of Delphi VIII and
                                         Delphi Bio, collectively referred to herein as the Delphi VIII Funds. Mr. Roeder is a
                                         Managing Member of DMP VIII and may be deemed to share voting and dispositive power over
                                         the shares held by the Delphi VIII Funds. This information has been obtained from a Schedule
                                         13G/A filed on February 7, 2020 by Delphi VIII, Delphi Bio, DMP VIII, Douglas A. Roeder,
                                         James J. Bochnowski, David L. Douglass and Deepika R. Pakianathan.
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | (16) | Consists
                                         of (a) 56,004 shares of common stock and (b) 361,193 shares of common stock underlying
                                         options that are exercisable within 60 days of March 31, 2020.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
| |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | (17) | Consists
                                         of (a) 11,513,940 shares of common stock and (b) 9,537,071 shares of common stock underlying
                                         options that are exercisable within 60 days of March 31, 2020.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   



Securities
Authorized for Issuance Under Equity Compensation Plans



The
following table provides certain information regarding our equity compensation plans in effect as of December 31, 2019:



|Plan
    Category                                              |  | Number
    of securities to be issued upon exercise of outstanding options, warrants and rights (a) |            |  | Weighted-average
    exercise price of outstanding options, warrants and rights (b) |   |      | Number
    of securities remaining available for future issuance under equity compensation plans (excluding securities
    reflected in column (a)) (c) | 
|-------------------------------------------------------------- |  | --------------------------------------------------------------------------------------------------- | ---------- |  | ----------------------------------------------------------------------------------- | - | ---- | ------------------------------------------------------------------------------------------------------------------------------------------------------- | 
|Equity
    compensation plans approved by security holders     |  |                                                                                                     | 23,392,259 |  |                                                                                     | $ | 2.18 |                                                                                                                                                         | 
|Equity
    compensation plans not approved by security holders |  |                                                                                                     | 808,000    |  |                                                                                     |   | 1.65 |                                                                                                                                                         | 
|​                                                              |  |                                                                                                     | ​          |  |                                                                                     |   | ​​   |                                                                                                                                                         | 
|Total                                                          |  |                                                                                                     | 24,200,259 |  |                                                                                     |   |      |                                                                                                                                                         | 










| | (1) | Consists
                                         of 4,852,081 shares available under the 2015 plan and 4,873,706 shares available
                                         under the 2016 Employee Stock Purchase Plan, or the 2016 ESPP. On January 1 of each year,
                                         the number of shares reserved under the 2015 plan and 2016 ESPP is automatically increased
                                         by 3.5% and 1%, respectively, of the total number of shares of common stock that are
                                         outstanding at that time, or a lesser number of shares as may be determined by our Board.
                                         An additional 7,120,848 and 2,034,528 shares were added to the number of available shares
                                         under the 2015 plan and the 2016 ESPP, respectively, in each case effective January 1,
                                         2020.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |     |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
| | (2) | Consists
                                         of shares available under our Inducement Plan that was in effect as of May 30, 2019 and
                                         was adopted without the approval of our security holders. A description of the Inducement
                                         Plan is contained in Note 13 of the Notes to the Consolidated Financial Statements contained
                                         in our Annual Report on Form 10-K for the year ended December 31, 2019.                                                                                                                                                                                                                                                                                                                                                                                                                                                         



16







Item 13.
Certain Relationships and Related Transactions, and Director Independence



Transactions
with Related Persons



Related-Person
Transactions Policy and Procedures



We
have adopted a related party transaction policy that sets forth our procedures for the identification, review, consideration and
approval or ratification of related party transactions. For purposes of our policy only, a related party transaction is a transaction,
arrangement or relationship, or any series of similar transactions, arrangements or relationships, in which we and any related
party are, were or will be participants in which the amount involved exceeds $120,000. Transactions involving compensation for
services provided to us as an employee or director are not covered by this policy. A related party is any executive officer, director
or beneficial owner of more than 5% of any class of our voting securities, including any of their immediate family members and
any entity owned or controlled by such persons.



Under
the policy, if a transaction has been identified as a related party transaction, including any transaction that was not a related
party transaction when originally consummated or any transaction that was not initially identified as a related party transaction
prior to consummation, our management must present information regarding the related party transaction to our Audit Committee,
or, if Audit Committee approval would be inappropriate, to another independent body of our Board of Directors, for review, consideration
and approval or ratification. The presentation must include a description of, among other things, the material facts, the interests,
direct and indirect, of the related parties, the benefits to us of the transaction and whether the transaction is on terms that
are comparable to the terms available to or from, as the case may be, an unrelated third party or to or from employees generally.
Under the policy, we will collect information that we deem reasonably necessary from each director, executive officer and, to
the extent feasible, significant stockholder to enable us to identify any existing or potential related-person transactions and
to effectuate the terms of the policy. In addition, under our Code of Conduct, our employees and directors will have an affirmative
responsibility to disclose any transaction or relationship that reasonably could be expected to give rise to a conflict of interest.
In considering related party transactions, our Audit Committee, or other independent body of our Board of Directors, will take
into account the relevant available facts and circumstances including:



| | • | the
                                         risks, costs and benefits to us;
| | - | -----------------------------------------------------------------------------
| |   |                                                                              

| | • | the
                                         impact on a director's independence in the event that the related party is a director,
                                         immediate family member of a director or an entity with which a director is affiliated;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |   |                                                                                                                                                                                                                                                                     

| | • | the
                                         availability of other sources for comparable services or products; and
| | - | -------------------------------------------------------------------------------------------------------------------
| |   |                                                                                                                    

| | • | the
                                         terms available to or from, as the case may be, unrelated third parties or to or from
                                         employees generally.
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The
policy requires that, in determining whether to approve, ratify or reject a related party transaction, our Audit Committee, or
other independent body of our Board of Directors, must consider, in light of known circumstances, whether the transaction is in,
or is not inconsistent with, our best interests and those of our stockholders, as our Audit Committee, or other independent body
of our Board of Directors, determines in the good faith exercise of its discretion.



Certain
Related Party Transactions



Except
as described below, there have been no transactions since January 1, 2018 to which we have been a participant in which the amount
involved exceeded or will exceed $120,000, and in which any of our directors, executive officers or holders of more than 5% of
our capital stock, or any members of their immediate family, had or will have a direct or indirect material interest, other than
compensation arrangements which are described under "Executive Compensation" and "Non-Employee Director Compensation."





17







Registration
Rights Agreement



We
have entered into a registration rights agreement with certain of our 5% stockholders.



The
registration rights agreement, among other things grants certain of our stockholders specified registration rights with respect
to shares of our common stock issued upon conversion of the shares of Senseonics, Incorporated stock previously held by them.



Indemnification
Agreements



Our
amended and restated certificate of incorporation contains provisions limiting the liability of directors, and our amended and
restated bylaws provides that we will indemnify each of our directors to the fullest extent permitted under Delaware law. Our
amended and restated certificate of incorporation and amended and restated bylaws also provide our Board of Directors with discretion
to indemnify our officers and employees when determined appropriate by our Board of Directors.



In
addition, we have entered into an indemnification agreement with our directors and executive officers.



Independence
of the Board of Directors



As
required under the NYSE American listing rules, a majority of the members of a listed company's board of directors must qualify
as "independent," as affirmatively determined by our Board of Directors. Our Board of Directors consults with our counsel
to ensure that its determinations are consistent with relevant securities and other laws and regulations regarding the definition
of "independent," including those set forth in pertinent listing standards of NYSE American, as in effect from time
to time.



Our
Board of Directors has undertaken a review of the independence of the directors and considered whether any director has a material
relationship with us that could compromise his or her ability to exercise independent judgment in carrying out his or her responsibilities.
As a result of this review, our Board of Directors has determined that Messrs. DeFalco, Fiorentino, Prince and Roeder and Drs.
Edelman and Klein, representing six of our eight directors, are "independent directors" as defined under the listing
rules of the NYSE American. In addition, our Board of Directors determined that M. James Barrett, who served on our board until
his retirement in June 2019, was an “independent director” as defined under the listing rules of the NYSE American.
In making these determinations, our Board of Directors found that none of these directors or nominees for director had a material
or other disqualifying relationship with us. Dr. Goodnow is not an independent director by virtue of his employment with us as
our President and Chief Executive Officer and Dr. Kaufman is not an independent director by virtue of her employment with us as
our Chief Medical Officer.



In
addition, each of the members of each of the Audit Committee, the Compensation Committee and the Nominating and Corporate Governance
Committee are independent, as determined in accordance with the applicable independence requirements for such committee.





18







Item 14. Principal Accounting Fees and Services



Principal
Accountant Fees and Services



The
following table represents aggregate fees billed to us for the fiscal years ended December 31, 2019 and 2018 by our principal
accountants. All such fees described below were pre-approved by our Audit Committee.



|                       |  | 2019 |           |     | 2018 |  
|---------------------- |  | ---- | --------- | --- | ---- | -
|Audit
    fees         |  | $    | 1,678,640 | (1) |      | $
|Audit-related
    Fees |  |      | 410,814   | (2) |      |  
|Total
    Fees         |  | $    | 2,089,454 |     |      | $



| | (1) | Includes
                                         the aggregate fees and out of pocket expenses billed for the integrated audit of our
                                         consolidated annual financial statements, and reviews of our interim consolidated financial
                                         statements included in quarterly reports on Form 10-Q.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |     |                                                                                                                                                                                                                                                                                                                                                                            

| | (2) | Includes
                                         services related to provision of comfort letters, consents, and review of documents for
                                         registration statements on Form S-3 and S-8 offering memorandums and supplemental prospectus
                                         filings, primarily in connection with our July 2019 financing activities and Open Market
                                         Sales Agreement with Jefferies LLC.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Pre-Approval
Policies and Procedures



Our
Audit Committee has adopted a policy and procedures for the pre-approval of audit and, if applicable, non-audit services rendered
by our independent registered public accounting firm, Ernst & Young LLP. The policy generally pre-approves specified services
in the defined categories of audit services, audit-related services, and tax services up to specified amounts. Pre-approval may
also be given as part of our Audit Committee's approval of the scope of the engagement of the independent registered public accounting
firm or on an individual explicit case-by-case basis before the independent registered public accounting firm is engaged to provide
each service. On a periodic basis, the independent registered public accounting firm reports to our Audit Committee on the status
of actual costs for approved services against the approved amounts.



All
of the services of Ernst & Young LLP for the years ended December 31, 2019 and 2018 described above were pre-approved in accordance
with the Audit Committee Pre-Approval Policy.





19







PART IV



Item 15.
Exhibits, Financial Statement Schedules



|Exhibit
Number |  | Description
of Document                                                                                                                                                                                                 
|-------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|10.1+          |  | Severance
Agreement and Release, by and between Senseonics, Incorporated and Jon D. Isaacson, dated as of November 12, 2019.                                                                                            
|10.2           |  | Registration Rights Agreement, dated as of April 21, 2020, by and between the Registrant, and Highbridge Tactical Credit Master Fund, L.P.                                                                              
|10.3           |  | Registration Rights Agreement, dated as of April 21, 2020, by and between the Registrant, and Highbridge Tactical Credit Master Fund, L.P.                                                                              
|10.4           |  | Loan and Security Agreement among Wilmington Savings Fund Society, SCB as collateral agent, Highbridge Tactical Credit Master Fund, L.P., the Registrant and Senseonics, Incorporated dated as of April 21, 2020.       
|10.5           |  | Note Purchase and Exchange Agreement among Wilmington Savings Fund Society, SCB, as collateral agent, Highbridge Tactical Credit Master Fund, L.P., the Company and Senseonics, Incorporated dated as of April 21, 2020.
|10.6           |  | Form of Note representing the Registrant's Secured Promissory First Lien Notes                                                                                                                                          
|10.7           |  | Form of Note representing the Registrant's Secured Promissory Second Lien Notes                                                                                                                                         
|10.8           |  | Form of Warrant to Purchase Common Stock issued to Highbridge Tactical Credit Master Fund, L.P.                                                                                                                         
|31.1           |  | Certification
of Principal Executive Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities Exchange Act of 1934,
as adopted pursuant to section 302 of the Sarbanes-Oxley Act of 2002.     
|31.2           |  | Certification
of Principal Financial Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities Exchange Act of 1934,
as adopted pursuant to section 302 of the Sarbanes-Oxley Act of 2002.     



+Indicates
management contract or compensatory plan.



20







SIGNATURES



Pursuant
to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended, the registrant has duly caused
this report to be signed on its behalf by the undersigned, thereunto duly authorized.



| | SENSEONICS
    HOLDINGS, INC.
| | -----------------------------
| | By:                          
| |                              
| |                              



Date:
April 28, 2020





Pursuant
to the requirements of the Securities Exchange Act of 1934, as amended, this report has been signed below by the following persons
on behalf of the registrant and in the capacities and on the dates indicated.



|Signature                          |  | Title                                                              |  | Date              
|---------------------------------- |  | ------------------------------------------------------------------ |  | ------------------
|                                   |  |                                                                    |  |                   
|/s/
    Timothy T. Goodnow, Ph.D.  |  | President,
    Chief Executive Officer and Director                |  | April
    28, 2020
|Timothy
    T. Goodnow, Ph.D.      |  | (Principal
    Executive Officer)                                  |  |                   
|                                   |  |                                                                    |  |                   
|/s/
    NICK B. TRESSLER           |  | Chief
    Financial Officer                                        |  | April
    28, 2020
|Nick
    B. Tressler               |  | (Principal
    Financial Officer and Principal Accounting Officer) |  |                   
|                                   |  |                                                                    |  |                   
|*                                  |  | Chairman
    of the Board of Directors                             |  | April
    28, 2020
|Stephen
    P. DeFalco             |  |                                                                    |  |                   
|                                   |  |                                                                    |  |                   
|*                                  |  | Director                                                           |  | April
    28, 2020
|Steven
    Edelman, M.D.           |  |                                                                    |  |                   
|                                   |  |                                                                    |  |                   
|*                                  |  | Director                                                           |  | April
    28, 2020
|Edward
    J. Fiorentino           |  |                                                                    |  |                   
|                                   |  |                                                                    |  |                   
|*                                  |  | Director                                                           |  | April
    28, 2020
|Peter
    Justin Klein, M.D., J.D. |  |                                                                    |  |                   
|                                   |  |                                                                    |  |                   
|*                                  |  | Director                                                           |  | April
    28, 2020
|Douglas
    Prince                 |  |                                                                    |  |                   
|                                   |  |                                                                    |  |                   
|*                                  |  | Director                                                           |  | April
    28, 2020
|Douglas
    Roeder                 |  |                                                                    |  |                   
|                                   |  |                                                                    |  |                   
|*                                  |  | Director
    and Chief Medical Officer                             |  | April
    28, 2020
|Francine
    Kaufman, M.D.         |  |                                                                    |  |                   



|*
    By: | /s/
                                         Timothy T. Goodnow, Ph.D. | 
|--------- | ---------------------------------------------------------------------- | 
|          | Timothy
    T. Goodnow, Ph.D.                                         
|          | Attorney-in-Fact                                                      





21