UNITED
STATES

SECURITIES
AND EXCHANGE COMMISSION

Washington,
D.C. 20549



FORM
20-F/A

(Amendment
No. 1)



☐
REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934



OR



☒
ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934



For
the fiscal year ended December 31, 2018



OR



☐
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934



OR



☐
SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934



Date
of event requiring this shell company report ________



Commission
file number 001-37643



|Kitov
    Pharma Ltd.                                                                                            
|-----------------------------------------------------------------------------------------------------------------
|(Exact
    name of Registrant as specified in its charter)                                                       
|                                                                                                                 
|N/A                                                                                                              
|(Translation
    of Registrant’s name into English)                                                              
|                                                                                                                 
|Israel                                                                                                           
|(Jurisdiction
    of incorporation or organization)                                                              
|                                                                                                                 
|One
        Azrieli Center, Round Tower
        132
        Menachem Begin Road,Tel Aviv,
        6701101, Israel
|(Address
    of principal executive offices)                                                                     
|                                                                                                                 
|Gil
    Efron, Chief Financial Officer                                                                           
|One
        Azrieli Center, Round Tower
        132
        Menachem Begin Road,Tel Aviv,
        6701101, Israel
|Tel:
    +972-3-933-3121; Fax: +972-153-39333121                                                                 
|(Name,
    Telephone, E-mail and/or Facsimile number and Address of Company Contact Person)                      



Securities
registered or to be registered pursuant to Section 12(b) of the Act.



|Title
    of class                                                       |  | Name
    of each exchange on which registered
|------------------------------------------------------------------------ |  | ---------------------------------------------
|American Depositary
    Shares, each representing 20 Ordinary Shares (1) |  | NASDAQ Capital
    Market                    
|Ordinary Shares,
    no par value (2)                                    |  | N/A                                          
|Warrants to purchase
    our American Depositary Shares                  |  | NASDAQ Capital
    Market                    



| | (1) | Evidenced
by American Depositary Receipts.
| | --- | ------------------------------------------

| | (2) | Not
for trading, but only in connection with the listing of the American Depositary Shares.
| | --- | -------------------------------------------------------------------------------------------



|Securities
    registered or to be registered pursuant to Section 12(g) of the Act:           
|----------------------------------------------------------------------------------------------
|                                                                                              
|None                                                                                          
|(Title of Class)                                                                              
|                                                                                              
|Securities for which
    there is a reporting obligation pursuant to Section 15(d) of the Act:
|                                                                                              
|None                                                                                          
|(Title of Class)                                                                              











Indicate
the number of outstanding shares of each of the issuer’s classes of capital or common stock as of the close of the period
covered by the annual report: 16,009,264 Ordinary Shares, no par value (including 1 share held in treasury)*



(*after
giving effect to a reverse share split of our ordinary shares, at an exchange ratio of 1-for-20, which was completed on January
4, 2019.)



Indicate
by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.



Yes
☐    No ☒



If
this report is an annual or transition report, indicate by check mark if the registrant is not required to file reports pursuant
to Section 13 or 15(d) of the Securities Exchange Act 1934.



Yes
☐    No ☒



Indicate
by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports),
and (2) has been subject to such filing requirements for the past 90 days.



☒
Yes    ☐ No



Indicate
by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant
to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that
the registrant was required to submit such files).



Yes
☒    No ☐



Indicate
by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or an emerging
growth company. See definition of “large accelerated filer,” “accelerated filer,” and “emerging
growth company” in Rule 12b-2 of the Exchange Act.



Large
accelerated filer ☐    Accelerated filer ☐



Non-accelerated
filer ☒



Emerging
growth company ☒



If
an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the
registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
provided pursuant to Section 13(a) of the Exchange Act. ☐



Indicate
by check mark which basis of accounting the registrant has used to prepare the financial statements included in this filing:



U.S.
GAAP ☐

International
Financing Reporting Standards as issued by the International Accounting Standards Board ☒

Other
☐



If
“Other” has been checked in response to the previous question, indicate by check mark which financial statement item
the registrant has elected to follow.



Item
17 ☐    Item 18 ☐



If
this is an annual report, indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange
Act).



Yes
☐    No ☒



APPLICABLE
ONLY TO ISSUERS INVOLVED IN BANKRUPTCY PROCEEDINGS DURING THE PAST FIVE YEARS)



Indicate
by check mark whether the registrant has filed all documents and reports required to be filed by Sections 12, 13 or 15(d) of the
Securities Exchange Act of 1934 subsequent to the distribution of securities under a plan confirmed by a court.



Yes
☐    No ☐


















Explanatory
Note



This
Amendment No. 1 (this “Amendment”) to our annual report on Form 20-F for the fiscal year ended December 31, 2018
(the “Form 20-F”), filed on March 26, 2019 (the “Original Filing Date”), is being filed solely to
correct the hyperlinks on Exhibits 2.9 and 2.10, and to replace Exhibits 4.15, 4.16 and 4.17 with the attached Exhibits 4.15,
4.16 and 4.17 (the “Exhibits”) to reflect  amendments to paragraph 4(a) of Instructions as to
Exhibits of Form 20-F, governing redaction of confidential information in material contracts, which became effective as of
April 2, 2019.





Additionally, in connection with the filing of this Amendment,
the Company is including certifications of the Company’s Chief Executive Officer and Chief Financial Officer pursuant to
Rule 13a-14(a) or Rule 15d-14(a) of the Exchange Act. The Company is not including certifications pursuant to Section 1350 of Chapter
63 of Title 18 of the United States Code (18 U.S.C.1350) as no financial statements are being filed with this Amendment.



Except
for the revised Exhibits, this Amendment does not amend any other information set forth in the Form 20-F. This Amendment speaks
as of the Original Filing Date, does not reflect any events that may have occurred subsequent to the Original Filing Date, and
does not modify or update in any way any disclosures made in the Form 20-F.











PART III



|ITEM 19. | EXHIBITS
|-------- | --------



The exhibits filed with or incorporated into
this Annual Report on Form 20-Fare listed in the index of exhibits below:



|Exhibit
    Number |  | Exhibit Description                                                                                                                                                                                                                                                                                                                                     
|------------------ |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|1.1                |  | Memorandum of Association of the Registrant(originally filed as Exhibit 1.1 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on March 26, 2019 and incorporated herein by reference thereto).                                                                                                        
|1.2                |  | Amended and Restated Articles of Association of the Registrant (originally filed as Exhibit 1.2 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on March 26, 2019 and incorporated herein by reference thereto).                                                                                    
|2.1                |  | Form of Deposit Agreement among the Registrant, the Bank of New York Mellon, as Depositary, and all Owners and Holders from time to time of American Depositary Shares issued hereunder (incorporated by reference to Exhibit 4.1 to our Registration Statement on Form F-1 as filed with the Securities and Exchange Commission on September 24, 2015).
|2.2                |  | Form of Warrant Agent Agreement (incorporated by reference to Exhibit 4.2 to our Registration Statement on Form F-1/A as filed with the Securities and Exchange Commission on November 18, 2015).                                                                                                                                                       
|2.3                |  | Form of American Depositary Receipt (incorporated by reference to prospectus filed with the Securities and Exchange Commission on January 4, 2019)                                                                                                                                                                                                      
|2.4                |  | Form of Underwriters’ Warrant (incorporated by reference to Exhibit 4.4 to our Registration Statement on Form F-1/A as filed with the Securities and Exchange Commission on November 18, 2015).                                                                                                                                                         
|2.5                |  | Form of Placement Agent Warrant (incorporated by reference to Exhibit 4.5 to the Registrant’s Registration Statement on Form F-1 as filed with the Securities and Exchange Commission on June 27, 2016).                                                                                                                                                
|2.6                |  | Form of Letter Amendment to Warrant Agent Agreement with respect to Series A warrants (incorporated by reference to Exhibit 4.1 to the Registrant’s Form 6-K furnished to the Securities and Exchange Commission on June 29, 2016)                                                                                                                      
|2.7                |  | Form of Pre-Funded Series B Warrant Agreement (incorporated by reference to Exhibit 4.4 to the Registrant’s Registration Statement on Form F-1 as filed with the Securities and Exchange Commission on June 27, 2016).                                                                                                                                  
|2.8                |  | Stock Purchase Agreement, dated January 12, 2017, by and between the Registrant and Goldman Hirsh Partners Ltd. (incorporated by reference to Exhibit 2.8 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on May 1, 2017).                                                                          
|2.9                |  | Shareholder’s Undertaking by Goldman Hirsh Partners Ltd. dated January 13, 2017. (incorporated by reference to Exhibit 2.9 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on May 1, 2017)                                                                                                          
|2.10               |  | Flow of Funds Agreement, dated April 9, 2017, by and between the Registrant and Goldman Hirsh Partners Ltd. (incorporated by reference to Exhibit 2.10 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on May 1, 2017)                                                                              
|2.11               |  | Form of Warrant issued to purchasers in the July 2017 offering (incorporated by reference to Exhibit 4.1 to the Registrant’s Form 6-K furnished to the Securities and Exchange Commission on July 14, 2017)                                                                                                                                             
|2.12               |  | Form of Placement Agent Warrant (incorporated by reference to Exhibit 4.2 to the Registrant’s Form 6-K furnished to the Securities and Exchange Commission on July 14, 2017)                                                                                                                                                                            
|2.13               |  | Stock Purchase Agreement, dated October 3, 2017, by and among the Registrant, Certain Stockholders of TyrNovo Ltd. and the Stockholders’ Representative (incorporated by reference to Exhibit 2.13 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on March 5, 2018)                                
|2.14               |  | Form of Warrant issued to purchasers in the June 2018 offering (incorporated by reference to Exhibit 4.1 to the Registrant’s Form 6-K furnished to the Securities and Exchange Commission on June 5, 2018)                                                                                                                                              
|2.15               |  | Form of Placement Agent Warrant (incorporated by reference to Exhibit 4.2 to the Registrant’s Form 6-K furnished to the Securities and Exchange Commission on June 5, 2018)                                                                                                                                                                             
|2.16               |  | Form of Warrant issued to purchasers in the January 2019 offering (incorporated by reference to Exhibit 4.1 to the Registrant’s Form 6-K furnished to the Securities and Exchange Commission on January 18, 2019)                                                                                                                                       
|2.17               |  | Form of Placement Agent Warrant (incorporated by reference to Exhibit 4.2 to the Registrant’s Form 6-K furnished to the Securities and Exchange Commission on January 18, 2019)                                                                                                                                                                         





1







|4.1    |  | Form of Letter of Exemption adopted on July 2013 (unofficial English translation from Hebrew) (incorporated by reference to Exhibit 10.5 to our Registration Statement on Form F-1  filed with the Securities and Exchange Commission on September 24, 2015).                                                                                    
|------ |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|4.2    |  | Form of Letter of Indemnity adopted on July 2013 (unofficial English translation from Hebrew) (incorporated by reference to i Exhibit 10.6 to our Registration Statement on Form F-1 as filed with the Securities and Exchange Commission on September 24, 2015).                                                                                
|4.3    |  | Kitov Pharma Ltd. 2016 Equity-Based Incentive Plan (incorporated by reference to Annex C to the Proxy Statement included as Exhibit 99.1 to the Registrant’s Form 6-k furnished to the Securities and Exchange Commission on March 22, 2019)                                                                                                     
|4.4    |  | Form of Underwriting Agreement (incorporated by reference to Exhibit 1.1 to our Registration Statement on Form F-1/A filed with the Securities and Exchange Commission on November 18, 2015).                                                                                                                                                    
|4.5    |  | Form of Share Purchase Agreement between Kitov Pharma and the purchasers (incorporated by reference to Exhibit 1.1 to the Registrant’s Form 6-K furnished to the Securities and Exchange Commission on June 29, 2016)                                                                                                                            
|4.6*   |  | License Agreement, dated as of August 15, 2013, by and between Yissum Research Development Company of The Hebrew University of Jerusalem, Ltd. and TyrNovo Ltd. (incorporated by reference to Exhibit 4.14 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on May 1, 2017)                   
|4.7*   |  | First Amendment to License Agreement, dated as of April 8, 2014, by and between Yissum Research Development Company of The Hebrew University of Jerusalem, Ltd. and TyrNovo Ltd. (incorporated by reference to Exhibit 4.15 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on May 1, 2017)  
|4.8*   |  | Second Amendment to License Agreement, dated as of March 16, 2017, by and between Yissum Research Development Company of The Hebrew University of Jerusalem, Ltd. and TyrNovo Ltd. (incorporated by reference to Exhibit 4.16 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on May 1, 2017)
|4.9    |  | Form of Securities Purchase Agreement dated as of July 11, 2017 by and between the Registrant and the purchasers in the offering (incorporated by reference to Exhibit 1.1 to the Registrant’s Form 6-K furnished to the Securities and Exchange Commission on July 14, 2017)                                                                    
|4.10   |  | Kitov Pharma Ltd. Office Holder Compensation Policy approved the shareholders on July 12, 2017 (incorporated by reference to Exhibit A to the Proxy Statement included as Exhibit 99.1 to the Registrant’s Form 6-k furnished to the Securities and Exchange Commission on June 8, 2017)                                                         
|4.11   |  | Revolving Secured Facility and Pledge Agreement dated March 1, 2017 by and between TyrNovo Ltd., and Kitov Pharma Ltd. (incorporated by reference to Exhibit 4.18 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on March 5, 2018)                                                          
|4.12   |  | Convertible Bridge Loan Agreement, dated September 15, 2017, by and between Kitov Pharma Ltd. and TyrNovo Ltd. (incorporated by reference to Exhibit 4.19 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on March 5, 2018)                                                                  
|4.13   |  | Form of Securities Purchase Agreement dated as of June 1, 2018 by and between the Registrant and the purchasers in the offering (incorporated by reference to Exhibit 1.1 to the Registrant’s Form 6-K furnished to the Securities and Exchange Commission on June 5, 2018)                                                                      
|4.14   |  | Form of Securities Purchase Agreement dated as of January 16, 2019 by and between the Registrant and the purchasers in the offering (incorporated by reference to Exhibit 1.1 to the Registrant’s Form 6-K furnished to the Securities and Exchange Commission on January 18, 2019)                                                              
|4.15** |  | Product Manufacturing Agreement, effective as of November 8, 2018, by and between Kitov Pharma Ltd. and Dexcel Ltd.                                                                                                                                                                                                                              
|4.16** |  | Agreement dated as of December 27, 2018, by and between Kitov Pharma Ltd. and Coeptis Pharmaceuticals Inc.                                                                                                                                                                                                                                       
|4.17** |  | Stock Purchase Agreement by and among Kitov Pharma Ltd., The Stockholders of FameWave Ltd. and M. Arkin (1999) Ltd. dated as of March 14, 2019.                                                                                                                                                                                                  
|8.1    |  | List of subsidiaries of the Registrant (originally filed as Exhibit 8.1 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on March 26, 2019 and incorporated herein by reference thereto).                                                                                                     
|12.1   |  | Certification by Chief Executive Officer pursuant to section 302 of the Sarbanes-Oxley Act of 2002                                                                                                                                                                                                                                               
|12.2   |  | Certification by Chief Financial Officer pursuant to section 302 of the Sarbanes-Oxley Act of 2002                                                                                                                                                                                                                                               
|13.1   |  | Certification by Chief Executive Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (originally filed as Exhibit 13.1 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on March 26, 2019 and incorporated herein by reference thereto).                                        
|13.2   |  | Certification by Chief Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (originally filed as Exhibit 13.2 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on March 26, 2019 and incorporated herein by reference thereto).                                        
|15.1   |  | Consent of Somekh Chaikin, independent registered public accounting firm, a Member Firm of KPMG International (originally filed as Exhibit 15.1 to the Registrant’s Annual Report on Form 20-F as filed with the Securities and Exchange Commission on March 26, 2019 and incorporated herein by reference thereto).                             



* Confidential treatment granted with respect to portions of
this Exhibit.

** Portions of this exhibit have been omitted because they are
both (i) not material, and (ii) would likely cause competitive harm to the Company if publicly disclosed.





2







SIGNATURES



The registrant hereby certifies that it meets all of the requirements
for filing on Form 20-F and this Amendment No. 1 thereto, and that it has duly caused and authorized the undersigned to sign this
Amendment No. 1 to Annual Report on Form 20-F on its behalf.



|                    | KITOV PHARMA LTD.
|------------------- | -----------------
|                    |                  
|Date: April 3, 2019 | By:              
|                    |                  
|                    |                  
|                    |                  
|                    | By:              
|                    |                  
|                    |                  





3