EX-4.3





 Exhibit 4.3 

ELI LILLY AND COMPANY 

Officers’ Certificate Pursuant to 

Section 3.01 of the Indenture 

            , 2020 

 
  

The undersigned, Philip L. Johnson, Senior Vice President, Finance, and Treasurer of Eli Lilly and Company, an Indiana corporation (the
“Company”), and Crystal T. Williams, Assistant General Counsel and Assistant Corporate Secretary of the Company, pursuant to Section 3.01 of the Indenture dated as of February 1, 1991 (the “Indenture”),
between the Company and Deutsche Bank Trust Company Americas (as successor to Citibank, N.A.), as trustee (the “Trustee”), as authorized by resolutions of the Board of Directors of the Company, dated February 7, 2019, and
minutes of the Risk Management Committee of the Company at its meeting on April 16, 2020, do hereby certify as follows: 

(i)    There are hereby established one series of debt securities to be issued under the Indenture. The title of such
series of the debt securities shall be the “2.250% Notes due 2050” (the “Notes”). 

(ii)    The Notes shall be in the form, and shall have the terms, set forth as Annex A. The Notes shall be issued
in the form of Registered Securities and shall not be issued in the form of Bearer Securities. 
 (iii)    The initial
limit upon the aggregate principal amount of the Notes which may be authenticated and delivered under the Indenture (except for Notes authenticated and delivered upon registration or transfer of, or in exchange for, or in lieu of, other Notes
pursuant to Section 3.04, 3.05, 3.06, 4.03 or 10.04 of the Indenture) is one billion Dollars ($1,000,000,000); provided, however, that, without the consent of the Holders of any Securities, the Company may issue additional Securities having the
same terms as the Notes of a particular series other than the date of original issuance and the first Interest Payment Date applicable thereto. Any such additional Securities shall constitute a single series of Securities with the applicable
Notes under the Indenture. 
 (iv)    The principal amount of the Notes shall be payable on May 15, 2050, unless
redeemed prior to such time in accordance with clause (xi) below. 
 (v)    The Notes shall bear interest at the
rate of 2.250% per annum from May 5, 2020. The Interest Payment Dates for the Notes shall be May 15 and November 15 of each year, commencing on November 15, 2020. 

(vi)    Interest shall be payable to the person in whose name a Note (or any Predecessor Security) is registered at the
close of business on the Regular Record Date immediately preceding the applicable Interest Payment Date (or, in the case of Defaulted Interest, in the manner provided in Section 3.07 in the Indenture). The “Regular Record Date” for
the Notes shall be May 1 and November 1 (whether or not a Business Day (as defined in the Notes)). 












 (vii)    The Notes shall be denominated, and amounts due thereon shall
be payable, solely in Dollars. 
 (viii)    The Company shall at all times maintain a Place of Payment for the Notes in
the Borough of Manhattan, The City of New York. The Company initially appoints Deutsche Bank Trust Company Americas, with a corporate trust office at 60 Wall Street, 24th Floor, Mail Stop: NYC60-2407, New York, New York 10005 USA, for such purpose.

 (ix)    The Trustee is hereby appointed as the initial Paying Agent and the initial Security Registrar with respect
to the Notes. 
 (x)    The Notes shall not be subject to any sinking fund or analogous provisions, and no Holder of the
Notes shall have any right to cause the Company to redeem any Notes at the option of the Holder. 
 (xi)    The Notes
shall be redeemable, in whole or in part, at the option of the Company at any time at the redemption prices determined in accordance with, and upon the terms and the conditions set forth in, the Note and the Indenture. 

(xii)    The Notes shall be issuable in the form of Global Securities registered in the name of The Depository Trust
Company, as Depositary, or its nominee. The Global Securities representing the Notes may be exchanged for definitive Notes only in the circumstances set forth in the seventh and eighth paragraphs of Section 3.05 of the Indenture and in
accordance with Section 3.05 of the Indenture. 
 (xiii)    The Notes shall be issued in minimum denominations of
two thousand Dollars ($2,000.00) and any integral multiples of one thousand Dollars ($1,000.00) in excess thereof. 

(xiv)    Section 12.02 of the Indenture shall be applicable to the Notes. 

(xv)    The Notes shall rank equally and pari passu with all other unsecured and unsubordinated indebtedness of the
Company. 
 (xvi)    The Company shall not pay any additional amounts on any of the Notes to any Person, including any
Holder who is not a United States person, in respect of any tax, assessment or governmental charge withheld or deducted. 

(xvii)    For purposes of the Notes, the following terms shall have the meanings set forth below: (1)
“Discharged” means that the Company will be deemed to have paid and discharged the entire indebtedness represented by, and obligations under, the Securities of the series as to which Section 12.02 of the Indenture is specified as
applicable and to have satisfied all the obligations under the Indenture relating to the Securities of such series (and the Trustee, at the expense of the Company, will execute proper instruments acknowledging the same), except (A) the rights
of Holders thereof to receive, from the trust fund described in Section 12.02(q)(1) of the Indenture, payment of the principal of and the interest, if any, on such Securities when such payments are due, (B) the Company’s obligations
with respect to such Securities under Sections 3.05 and 3.06 (insofar as applicable to Securities of such series), 12.02 and 5.02 of the Indenture 

  
 2 













 
and the Company’s obligations to the Trustee under Section 7.05 of the Indenture, (C) the rights of Holders of Securities of any series with respect to the currency or currency
units in which they are to receive payments of principal, premium, if any, and, interest and (D) the rights, powers, trusts, duties and immunities of the Trustee hereunder, will survive such discharge. The Company will reimburse the trust fund
for any loss suffered by it as a result of any tax, fee or other charge imposed on or assessed against deposited U.S. Government Obligations or Foreign Government Securities, as the case may be, or any principal or interest paid on such obligations,
and, subject to the provisions of Section 7.05 of the Indenture, will indemnify the Trustee against any claims made against the Trustee in connection with any such loss. 

(2)     “Interest Payment Date,” when used with respect to any Security, means the Stated Maturity of an
installment of interest on such Security. 
 (3)    “Special Record Date” for the payment of any Defaulted
Interest on the Registered Security of any series means a date fixed by the Trustee pursuant to Section 3.07 of the Indenture. 

(4)    “Valuation Date” has the meaning specified in Section 3.11(e) of the Indenture.  

(xviii)    Each of the undersigned has read and understands the provisions of the Indenture setting forth the covenants
and conditions relating to the authentication and delivery by the Trustee of the Notes, and in respect of compliance with which this certificate is being delivered, and all definitions in the Indenture relating thereto; 

(xix)    Each of the undersigned has examined the Board Resolutions and the minutes of the Risk Management Committee of
the Company adopted as of or prior to the date hereof relating to the issuance, execution, authentication, delivery and dating of the Notes, and such agreements, certificates of public officials, certificates of officers or other representatives of
the Company and such other documents, certificates and corporate or other records as he or she has deemed necessary or appropriate as a basis for the opinion hereinafter expressed; 

(xx)    The examinations or investigations described in paragraphs (xviii) and (xix) are sufficient to enable each of
the undersigned to express an informed opinion as to whether or not the covenants and conditions precedent referred to above have been complied with in accordance with the terms of the Indenture; and 

(xxi)    In the opinion of each of the undersigned, all covenants and conditions precedent to the issuance by the Company
and the authentication and delivery by the Trustee of the Notes, as requested in the order, dated as of the date hereof, pursuant to which the Company has requested that the Trustee authenticate and deliver the Notes, have been complied with in
accordance with the terms of the Indenture. 
 Capitalized terms used herein without definition shall have the respective meanings ascribed
to such terms in the Indenture. 
 [The Remainder of This Page Intentionally Left Blank; Signature Page Follows]


  
 3 













 IN WITNESS WHEREOF, the undersigned have
hereunto set their hands on the date first set forth above. 
  

			
	ELI LILLY AND COMPANY
		
	By	 	  

	Name:	 	Philip L. Johnson
	Title:	 	 Senior Vice President, Finance and

Treasurer



  

			
	By	 	  

	Name:	 	Crystal T. Williams
	Title:	 	 Assistant General Counsel and
 Assistant
Corporate Secretary



 [Signature Page to Officers’ Certificate Pursuant to the Indenture] 












 Annex A 

FORM OF 2.250% NOTE 












 ELI LILLY AND COMPANY 

Form of 2.250% Note due 2050 
  

			
	Certificate No. [*]	  	CUSIP No. 532457 BY3
	Registered Global Security	  	ISIN No. US532457BY33

 UNLESS THIS GLOBAL NOTE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW
YORK CORPORATION (“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY NOTE ISSUED IS REGISTERED IN THE NAME OF [*] OR IN SUCH OTHER NAME AS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC AND ANY
PAYMENT IS MADE TO [*], ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF, [*], HAS AN INTEREST HEREIN. 

UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR NOTES IN DEFINITIVE REGISTERED FORM, THIS GLOBAL NOTE MAY NOT BE TRANSFERRED EXCEPT
AS A WHOLE BY DTC TO A NOMINEE OF DTC, OR BY A NOMINEE OF DTC TO DTC OR ANOTHER NOMINEE OF DTC, OR BY DTC OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR TO A NOMINEE OF SUCH SUCCESSOR DEPOSITARY. 

ELI LILLY AND COMPANY, an Indiana corporation (the
“Company,” which term includes any successor corporation under the Indenture referred to herein), for value received, hereby promises to pay to [*], or its registered assigns, the principal amount of [*] Dollars ($[*]) on
May 15, 2050 (the “Stated Maturity Date”), unless redeemed on any Redemption Date (as defined on the reverse hereof) (the Stated Maturity Date or any Redemption Date is referred to herein as the “Maturity
Date” with respect to the principal repayable on such date), upon surrender of this Note at the office or agency of the Company for such payment in The City of New York, in such coin or currency of the United States of America as at the
time of payment shall be legal tender for the payment of public and private debts, and to pay interest on the outstanding principal amount until the Maturity Date at the rate of 2.250% per annum, in like coin or currency, semi-annually on
May 15 and November 15 of each year, commencing on November 15, 2020, until the date on which payment of said principal amount has been made or duly provided for; provided, however, that if this Note is in the form of a Global
Security, then payments of principal of or premium, if any, or interest on this Note may be made at the Company’s option by wire transfer of immediately available funds to the account specified by the Depositary for this Note; provided
further, that if this Note is not in the form of a Global Security, then payments of principal of and premium, if any, and interest on this Note may be made at the Company’s option by check mailed to the address of the person entitled
thereto as 












 
such address shall appear in the records of the Security Registrar. Interest on this Note shall accrue on the outstanding principal amount thereof from, and including, the most recent Interest
Payment Date to which interest has been paid or provided for or, if no interest has been paid or duly provided for, from, and including, May 5, 2020, in each case to, but excluding, the applicable Interest Payment Date or the Maturity Date, as
the case may be. Interest shall be computed on the basis of a 360-day year of twelve 30-day months. The interest payable on any Interest Payment Date shall be payable to
the person in whose name this Note is registered at the close of business on the May 1 and November 1 (whether or not a Business Day) immediately preceding such Interest Payment Date, except as otherwise provided in the Indenture. 

If the Maturity Date or any Interest Payment Date falls on a day which is not a Business Day, principal, premium, if any, and interest, if
any, payable with respect to the Maturity Date or such Interest Payment Date, as the case may be, shall be paid on the next succeeding Business Day with the same force and effect as if made on the Maturity Date or such Interest Payment Date, as the
case may be, and no additional interest shall accrue on the amount so payable for the period from and after the Maturity Date or such Interest Payment Date, as the case may be, to the next succeeding Business Day. As used herein,
“Business Day” shall mean any day, other than a Saturday or Sunday, that is neither a legal holiday nor a day on which banking institutions are authorized or required by law or regulation to close in The City of New York.

 This Note is issued pursuant to, and shall be governed by, that certain Indenture (the “Indenture”), dated as of
February 1, 1991, between the Company and Deutsche Bank Trust Company Americas (as successor to Citibank, N.A.), as trustee (the “Trustee”). Capitalized terms used in this Note without definition shall have the
respective meanings ascribed to them in the Indenture. 
 The provisions of this Note are continued on the reverse hereof, and such
continued provisions shall for all purposes have the same effect as though fully set forth at this place. 
 Unless the certificate of
authentication hereon has been executed by the Trustee by the manual signature of one of its authorized officers, this Note shall not be entitled to the benefit under the Indenture or be valid or obligatory for any purpose. 

[This Space Intentionally Left Blank] 












 IN WITNESS WHEREOF, Eli Lilly and Company has
caused this instrument to be duly signed. 
  

			
	ELI LILLY AND COMPANY
		
	By:	 	  

	Name:	 	
	Title:	 	
		 	
		 	  

	Name:	 	
	Title:	 	


 [SEAL] 












 This is one of the Securities of the series designated therein issued under the
within-mentioned Indenture. 
 Dated: May    , 2020 

 

	
	 DEUTSCHE BANK TRUST COMPANY
AMERICAS,
 as Trustee

	
	 By:
                                         
                               

	
                   
     Authorized Officer



 [REVERSE OF NOTE] 

This Note is one of a duly authorized issue of a series of debt securities (the “Securities”) of the Company,
designated as its 2.250% Notes due 2050 (the “Notes”). The Securities, including the Notes, are all issued or to be issued under and pursuant to the Indenture, to which Indenture, and all Board Resolutions and Officers’
Certificates as provided therein, reference is hereby made for a description of the rights, limitation of rights, obligations, duties and immunities thereunder of the Company, the Trustee and the Holders of the Notes, and the terms upon which the
Notes are, and are to be, authenticated and delivered. The Notes are initially limited to one billion Dollars ($1,000,000,000) aggregate principal amount; provided, however, that the Company may at any time issue additional Securities
under the Indenture in unlimited amounts having the same terms as the Notes other than the date of original issuance and the first Interest Payment Date applicable thereto, and such Securities shall be treated as a single series with the Notes for
all purposes under the Indenture. 
 This Note shall constitute part of the Company’s unsecured and unsubordinated obligations and
shall rank equally in right of payment with all of the Company’s other existing and future unsecured and unsubordinated indebtedness. This Note shall be issuable in fully registered form only, in minimum denominations of two thousand Dollars
($2,000) and any integral multiples of one thousand Dollars ($1,000) in excess of that amount. 
 In case an Event of Default shall have
occurred and be continuing with respect to this Note, the principal hereof may be declared due and payable, and upon such declaration shall become due and payable, in the manner, with the effect, and subject to the conditions provided in the
Indenture. The Indenture permits the Holders of at least a majority in aggregate principal amount of the Notes at the time outstanding to, on behalf of the Holders of all of the Notes and in the manner and subject to the provisions of the Indenture,
waive certain past defaults and rescind and annul such past declarations and their consequences under the Indenture. 
 The Indenture
contains provisions permitting the Company and the Trustee, with consent of the Holders of not less than a majority of the aggregate principal amount of the Notes at the time outstanding, evidenced as provided in the Indenture, to execute
supplemental 












 
indentures for the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of the Indenture or of any supplemental indenture with respect to the Notes
or of modifying in any manner the rights of the Holders of the Notes; provided, however, that no such supplemental indenture shall (i) extend the fixed maturity, or the earlier optional date of maturity, if any, of any Note, or
reduce the principal amount thereof or the premium thereon, if any, or reduce the rate or extend the time of payment of interest, if any, thereon or make the principal thereof or premium, if any, or interest, if any, thereon payable in any currency
other than as provided pursuant to the Indenture or this Note, without the consent of the Holders of each Note so affected; or (ii) reduce the aforesaid percentage of the Notes, the Holders of which are required to consent to any such
supplemental indenture, without the consent of the Holders of all Notes then outstanding. 
 The Notes shall not be entitled to the benefit
of any mandatory redemption, sinking fund or analogous provisions. 
 Upon such notice as specified below and in accordance with the
Indenture and the terms of this Note, the Notes are subject to redemption, in whole or in part, at the election of the Company at any time or from time to time, on a date fixed for redemption (a “Redemption Date”) prior to
the Par Call Date and at a “redemption price” equal to the greater of the following amounts: 
  

	 	(i)	 100% of the principal amount of the Notes being redeemed on such Redemption Date; and 



 

	 	(ii)	 the sum of the present values of the remaining scheduled payments of principal of and interest on the Notes
being redeemed that would be due if such Notes matured on the Par Call Date (not including the amount, if any, of unpaid interest accrued to, but excluding, such Redemption Date) discounted to such Redemption Date on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 0.200% (or 20 basis points); 



plus, in each case, unpaid interest accrued on such Notes to, but excluding, such Redemption Date. If the Company redeems all or any part of the Notes on or
after the Par Call Date, it shall pay a redemption price equal to 100% of the principal amount of the Notes being redeemed plus accrued and unpaid interest hereon. 

Notwithstanding the foregoing, installments of interest on the Notes that are due and payable on each Interest Payment Date falling on or
prior to a Redemption Date shall be payable on such Interest Payment Date to the Holder(s) as of the close of business on the Regular Record Date immediately preceding such Interest Payment Date. 

The Company shall mail notice of each redemption at least 10 days but not more than 60 days before the Redemption Date to each Holder of Notes
to be redeemed. Each notice of redemption shall (i) specify the Redemption Date and the redemption price at which the Notes are to be redeemed, (ii) state the applicable conditions precedent to such redemption, if any, as described below,
and (iii) state that payment of the redemption price of the Notes to be 












 
redeemed, together with interest accrued thereon to the Redemption Date (except that if such Redemption Date is an Interest Payment Date, such interest due on such date shall be payable to the
Holder on the Regular Record Date for such Interest Payment Date), will be made at the office or agency to be maintained by the Company in accordance with Section 5.02 of the Indenture (or, if desired by the Company, at the principal office of
the Trustee) upon presentation and surrender of such Notes and that from and after said date any interest thereon will cease to accrue. 

Any notice of redemption may, at the Company’s discretion, be subject to one or more conditions precedent, including completion of a
corporate transaction. In such event, the related notice of redemption shall describe each such condition and, if applicable, shall state that, at the Company’s discretion, the Redemption Date may be delayed until such time (including more than
60 days after the notice of redemption was given) as any or all such conditions shall be satisfied (or waived by the Company in its sole discretion), or such redemption may not occur and such notice may be rescinded in the event that any or all such
conditions shall not have been satisfied or waived by the Redemption Date, or by the Redemption Date so delayed. If any such redemption has been rescinded or delayed, the Company shall provide written notice to the Trustee prior to the close of
business two Business Days prior to the Redemption Date and a written request to the Trustee to promptly provide such notice to each Holder, and upon receipt the Trustee shall provide such notice to each Holder. Subject to any delay in the
Redemption Date or rescission of the notice of redemption as described above, once notice of redemption is mailed, the Notes called for redemption shall become due and payable on the applicable Redemption Date at the applicable redemption price.

 “Comparable Treasury Issue” means, for the Notes, the United States Treasury security selected by the Reference
Treasury Dealer as having a maturity comparable to the remaining term of such Notes to be redeemed (assuming for this purpose that the Notes matured on the Par Call Date) that would be utilized, at the time of selection and in accordance with
customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of such Notes. 

“Comparable Treasury Price” means, with respect to any Redemption Date prior to the Par Call Date, (A) if the
Company obtains five or more Reference Treasury Dealer Quotations for such Redemption Date, the average of such Reference Treasury Dealer Quotations after excluding the highest and lowest of such Reference Treasury Dealer Quotations, (B) if the
Company obtains fewer than five but more than one Reference Treasury Dealer Quotation(s), the average of such Reference Treasury Dealer Quotations, or (C) if the Company obtains only one Reference Treasury Dealer Quotation, such Reference
Treasury Dealer Quotation. 
 “Par Call Date” means November 15, 2049. 

“Reference Treasury Dealer” means (A) each of BofA Securities, Inc., Barclays Capital Inc., Credit Suisse
Securities (USA) LLC and Goldman Sachs & Co. LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided, however, that if any of the foregoing shall cease to be a primary
U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company shall substitute therefor another Primary Treasury Dealer; and (B) any other Primary Treasury Dealer(s) selected by the
Company. 












 “Reference Treasury Dealer Quotation” means, with respect to each
Reference Treasury Dealer and any Redemption Date prior to the Par Call Date, the average, as determined by the Company, of the bid and asked prices for the Comparable Treasury Issue for such Notes (expressed in each case as a percentage of the
principal amount of the Notes) quoted in writing to the Company by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third Business Day preceding such Redemption Date. 

“Treasury Rate” means, with respect to any Redemption Date prior to the Par Call Date, the rate per annum equal to the
semi-annual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of the principal amount of the Notes to be redeemed) equal to the Comparable Treasury Price for
such Redemption Date. 
 On and after any Redemption Date, interest shall cease to accrue on the Notes or any portion of the Notes called
for redemption (unless the Company defaults in the payment of the redemption price therefor). Before any Redemption Date, the Company shall deposit with a Paying Agent (or the Trustee) money sufficient to pay the redemption price of the Notes to be
redeemed on such date. If fewer than all of the Notes are to be redeemed, then the Notes to be redeemed shall be selected by lot by the Depositary, in the case of Notes represented by a Global Security, or by the Trustee by a method the Trustee
deems to be fair and appropriate, in the case of Notes that are not represented by a Global Security. The Notes are subject to the defeasance provisions set forth in Section 12.02 of the Indenture. 

The Company shall not pay any additional amounts on any of the Notes to any person, including any Holder who is not a United States person in
respect of any tax, assessment or governmental charge withheld or deducted. 
 No reference herein to the Indenture and no provision of this
Note or of the Indenture or of any Board Resolution shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and premium, if any, and interest on this Note at the times and places and at the
rate and in the coin and currency herein prescribed. 
 This Note is transferable by the Holder hereof in person or by his or her attorney
duly authorized in writing on the books of the Company at the office or agency to be maintained by the Company for that purpose in The City of New York, but only in the manner, subject to the limitations and upon payment of any tax or governmental
charge for which the Company may require reimbursement as provided in the Indenture, and upon surrender and cancellation of this Note. Upon any registration of transfer, a new registered Note or Notes, of authorized denomination or authorized
denominations and like tenor and terms, and in the same aggregate principal amount, shall be issued to the transferee in exchange therefor. 

The Company, the Trustee, any Paying Agent and any Security Registrar may deem and treat the Holder hereof as the absolute owner of this Note
(whether or not this Note shall be overdue and notwithstanding any notations of ownership or other writing hereon made 












 
by anyone other than the Security Registrar) for the purpose of receiving payment of or on account of the principal hereof and premium, if any, and interest due hereon as herein provided and for
all other purposes, and none of the Company, the Trustee, any Paying Agent or any Security Registrar shall be affected by any notice to the contrary. 

No recourse shall be had for the payment of the principal of or premium, if any, or interest on this Note, or for any claim based hereon, or
otherwise in respect hereof, or based on or in respect of the Indenture or any indenture supplemental thereto or any Board Resolution, against any Person other than the Company or against any incorporator, stockholder, officer or director, past,
present or future, as such, of the Company or any other Person, whether by virtue of any constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise, all such liability being, by the acceptance hereof and as
part of the consideration for the issuance of this Note, expressly waived and released. 
 This Note shall be governed by and construed in
accordance with the laws of the State of New York.