Exhibit 10.1


 





Execution Version


 


INVESTOR RIGHTS AGREEMENT


 


This Investor
Rights Agreement (this “Agreement”) is made and entered into as of April 22, 2020 by and between Entasis
Therapeutics Holdings Inc., a Delaware corporation (the “Company”), and Innoviva, Inc., a Delaware corporation
(the “Purchaser”), in connection with that certain Securities Purchase Agreement, dated as of April 12, 2020,
by and between the Company and the Purchaser (the “Purchase Agreement”). Capitalized terms used herein have
the respective meanings ascribed thereto in the Purchase Agreement unless otherwise defined herein.


 


The parties hereby
agree as follows:


 


		1.	Certain
                                         Definitions.



 


As used in this Agreement,
the following terms shall have the following meanings:


 


“Applicable
Percentage” means, with respect to any person on any date of determination, the quotient, expressed as a percentage,
determined by dividing (i) the number of Company Common Stock owned (directly or indirectly) by such person determined on a Fully
Diluted Basis by (ii) the total number of Company Common Stock that are issued and outstanding determined on a Fully Diluted Basis.


 


“Board”
means the board of directors of the Company.


 


“Company Common
Stock” means the shares of common stock, par value $0.001 per share, of the Company.


 


“Exchange
Shares” means Company Common Stock issued or issuable upon the exchange of the Warrants pursuant to the terms thereof.


 


“Exempted
Securities” means


 


(i)     
Company Common Stock (or options or other rights to acquire Company Common Stock or securities convertible or exchangeable
into or exercisable for Company Common Stock) issued as a dividend or distribution on the Warrants;


 


(ii)    
Company Common Stock (or options or other rights to acquire Company Common Stock or securities convertible or exchangeable
into or exercisable for Company Common Stock) issued by reason of a dividend, stock split, split-up or other distribution of Company
Common Stock;


 


(iii)   
Company Common Stock (or options or other rights to acquire Company Common Stock or securities convertible or exchangeable
into or exercisable for Company Common Stock) issued to employees or directors of, or consultants or advisors to the Company or
any of its Subsidiaries pursuant to a plan, agreement or arrangement;


 


(iv)   
Company Common Stock (or options or other rights to acquire Company Common Stock or securities convertible or exchangeable
into or exercisable for Company Common Stock) issued to equipment lessors or to real property lessors, pursuant to equipment leasing
or real property leasing transaction; or


 









     


     


    

 


(v)    
Company Common Stock (or options or other rights to acquire Company Common Stock or securities convertible or exchangeable
into or exercisable for Company Common Stock) issued in connection with sponsored research, collaboration, technology license,
development, manufacturing, supply, distribution, marketing or other similar commercial agreements or strategic partnerships.


 


“Fully Diluted
Basis” means the number of shares of Company Common Stock outstanding or held (as the case may be) assuming, for the
purposes of calculating the number of shares of Company Common Stock held by the Investors, the conversion, exchange or exercise
of all securities or other instruments or rights held by the Investors that are convertible into or exercisable or exchangeable
for Company Common Stock. For purposes of this definition, all Warrants shall be deemed converted on the date of determination
in exchange for cash.


 


“Governmental
Entity” means any federal, state, local, foreign, international or multinational entity or authority exercising executive,
legislative, judicial, regulatory, administrative or taxing functions of or pertaining to government.


 


“New Securities”
means, collectively, (i) equity securities of the Company (including Company Common Stock), whether or not currently authorized,
(ii) debt securities, loans or other indebtedness of the company if any stockholder of the Company who, together with its Affiliates,
holds greater than five percent (5%) of the outstanding Company Common Stock, acquires or is offered the opportunity to acquire
such debt securities, loans or other indebtedness and (iii) any rights, options, or warrants to purchase any of the foregoing,
or securities of any type whatsoever that are, or may become, convertible or exchangeable into or exercisable for any of the foregoing.
For the avoidance of doubt, New Securities shall not include any Exempted Securities.


 


“Purchased
Shares” means the Company Common Stock acquired by the Purchaser pursuant to the Purchase Agreement.


 


		2.	[Reserved].



 


		3.	Participation
Rights.



 


(a)    
Subject to the terms and conditions of this Section 3 and applicable securities or blue sky laws, if the Company
proposes to issue, offer or sell any New Securities, the Company shall first offer such New Securities to the Purchaser in accordance
with the terms hereof.


 


(b)    
The Company shall give notice (the “Offer Notice”) to the Purchaser, stating (i) its bona fide intention
to offer or sell such New Securities, (ii) the number of such New Securities to be offered, and (iii) the price and terms, if any,
upon which it proposes to offer such New Securities.


 


(c)      By
written notification to the Company within twenty (20) days after the Offer Notice is delivered to the Purchaser, the
Purchaser may elect to purchase or otherwise acquire, at the price and on the terms specified in the Offer Notice, up to that
portion of such New Securities which equals the Purchaser’s Applicable Percentage. The failure of the Purchaser to
deliver such written notice within such time period shall be deemed an election by the Purchaser not to exercise its purchase
rights with respect to such Offer Notice. To the extent that the Company offers two (2) or more New Securities or other
securities in units, the Purchaser must purchase such units as a whole and will not be given the opportunity to purchase only
one of the securities making up such unit.


 






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(d)    
The Company shall sell all applicable New Securities to the Purchaser if it has elected to purchase such New Securities
on a date to be mutually determined by the Company and the Purchaser, which date shall be not later than end of the twenty (20)
day period commencing at the expiration of the initial twenty (20) day election period; provided, however, that such
twenty (20) day period shall be extended automatically if any approvals or consents of any Governmental Entities are required to
consummate the transaction and such approvals or consents are not received within such twenty (20) day period for up to an additional
one hundred twenty (120) days as long as such approvals or consents remain outstanding and the parties are continuing to exercise
commercially reasonable efforts to obtain them.


 


(e)     
Upon the expiration of the offering period described in Section 3(c), the Company will be free to sell, during the
one hundred twenty (120) day period commencing at the expiration of, as applicable, the initial twenty (20) day election period
following delivery of an Offer Notice, any New Securities that the Purchaser has not elected to purchase, at a sale price not less
than, and on other terms no less favorable to the Company than, those offered to the Purchaser as set forth in the Offer Notice,
provided, that such one hundred twenty (120) day period shall be extended automatically if any approvals or consents of
any Governmental Entities are required to consummate the transaction and such approvals or consents are not received within such
one hundred twenty (120) day period for up to an additional one hundred twenty (120) days as long as such approvals or consents
remain outstanding and the parties are continuing to exercise commercially reasonable efforts to obtain them. Any New Securities
offered or sold by the Company after such one hundred twenty (120) day period (as such period may be extended in accordance with
the immediately preceding sentence) must be reoffered to the Purchaser pursuant to this Section 3.


 


(f)     
The election by the Purchaser not to exercise its subscription rights under this Section 3 in any one instance shall
not affect its right (other than in respect of a reduction in its Applicable Percentage) as to any subsequent proposed issuance
of New Securities under this Section 3. The provisions of this Section 3 shall apply equally to any issuance or sale
by the Company or any of its Subsidiaries of securities or other instruments that would be deemed New Securities if issued by the
Company which, for the avoidance of doubt, shall not include any issuance of New Securities by a wholly owned Subsidiary to the
Company or to another wholly-owned Subsidiary of the Company. Subject to the terms of this Section 3, any sale of New Securities
by the Company or any other entity covered by the preceding sentence without first giving the Purchaser the rights described in
this Section 3 shall be null and void and of no force and effect.


 


(g)      Notwithstanding
the terms set forth in this Section 3, if the Board determines in good faith that the Company must issue New
Securities on an expedited basis without prior compliance with the terms of this Section 3 in order to avoid harm to
the Company (an “Expedited Issuance”), then, subject to compliance with the terms of the immediately
following sentence, the Company may effect and consummate such Expedited Issuance without complying with the terms set forth
in this Section 3 and shall not be deemed to be in breach of this Section 3 as a result thereof. As promptly as
practicable following the consummation of such Expedited Issuance, the Company and the Purchaser shall comply with the terms
of this Section 3 in respect of the New Securities issued in such Expedited Issuance such that the Purchaser has the
opportunity to participate in such Expedited Issuance of New Securities and be put in the same place (including in respect of
the percentage ownership of the equity securities of the Company) they would have been had such Expedited Issuance been
effected in accordance with the terms of this Section 3.


 






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(h)     
The provisions of this Section 3 (i) shall not apply to the issuance of Exempted Securities and (ii) shall terminate
and be of no further force or effect as of such time that the Purchaser, together with its Affiliates, have an Applicable Percentage
of less than 20%.


 


		4.	Board
Matters.



 


(a)     
For so long as the Purchaser, together with its Affiliates and permitted assignees (collectively, the “Investors”),
have an Applicable Percentage of at least 8%, at the request of the Investors, the Company shall cause the Board to consist of
not more than ten (10) members without the prior written consent of the Investors (which shall not be unreasonably withheld).


 


(b)    
For so long as the Investors, collectively, and together with their Affiliates, own at least eight percent (8%) of the then-outstanding
Company Common Stock, the Investors shall have the right to designate one (1) director to the Board, and for so long as the Investors,
collectively, and together with their Affiliates, continue to own at least fifteen percent (15%) of the then-outstanding Company
Common Stock, the Investors shall have the right to designate two (2) directors to the Board, in each case, in accordance with
the terms of this Section 4. Any directors designated by the Investors in accordance with this Section 4 shall be
referred to as “Investor Designees.” The right to designate one or more Investor Designees shall terminate and
be of no further force or effect as of such time that the Investors ownership decreases below the applicable threshold percentage
referenced in the first sentence of this Section 4(b). At any point in which the Investors are entitled to designate an
Investor Designee, the Investors may provide written notice (a “Designation Notice”) to the Company naming the
applicable Investor Designee(s) and demanding that the applicable Investor Designee(s) be appointed to the Board. Promptly, and
in any event within five (5) Business Days, following receipt of the Designation Notice, the Company shall cause the Investor Designees
to be appointed to the Board and assigned to be members of the class of directors as is consistent with the Company’s Amended
and Restated Bylaws. Any person designated by the Investor as an Investor Designee must possess the requisite financial and business
experience to serve as a director of the Company (it being understood that the directors and each of the executives and investment
professionals employed by the Investor or its Affiliates shall be deemed to possess such experience). If the Board and all applicable
committees of the Board reasonably determine that an Investor Designee satisfies the criteria in the foregoing sentence, the Board
shall nominate and appoint such Investor Designee to the Board. Following the delivery of a Designation Notice and prior to the
appointment of the Investor Designees to the Board, the Company shall not (and shall cause its Subsidiaries not to) take or approve
any action outside of the ordinary course of business or any other action that would represent a breach of Section 5.1 of the Purchase
Agreement.


 


(c)    
With respect to any vote of the Board, each director shall have one (1) vote and approval of all matters shall require the
affirmative vote of a majority of directors.


 









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(d)    
Subject to the terms of this Section 4, from and after the date hereof, the Company shall take all action within
its power to cause the covenants set forth in Section 4(a) and Section 4(b) to be fulfilled in all respects including:
(i) causing the Investor Designees to be named in any proxy statement of the Company with respect to the election of members of
the Board; (ii) soliciting the votes of stockholders in respect of the Investor Designees in the same manner and with the same
level of effort as with the solicitation in respect of other members of the Board; (iii) seeking to amend any organizational documents
of the Company necessary to give effect to the Investors’ rights hereunder as may reasonably be requested by the Investors;
and (iv) take all actions permitted by applicable law to cause the Investor Designees to be members of the Board (including the
appointment of the Investor Designees to the Board).


 


(e)     
Subject to clause (f) immediately below, in the event that an Investor Designee ceases to serve on the Board for any reason
(including the death, disability or resignation of such person), the Investors shall be entitled to appoint a new Investor Designee
in the place of such person, and the terms of this Section 4 shall apply equally to such replacement.


 


(f)     
In the event that the applicable threshold percentage of the Investors (and their Affiliates) falls below a threshold set
forth in Section 4(b) such that the Investors shall lose the right to designate one or more Investor Designees, if one or
more Investor Designee has been designated, the Investors shall identify which of the Investor Designees shall no longer be an
Investor Designee (such person, a “Departing Designee”), and which Investor Designee(s) (if any) will remain
as such; for the avoidance of doubt, the terms of this Section 4 shall continue to apply to any Investor Designee who is
not a Departing Designee. In the event of a Departing Designee, the Investors shall cause the removal or resignation of such Departing
Designee prior to the next annual meeting of the Company shareholders, and the provisions of Section 4(b) and (c)
shall not apply to such Departing Designee, and in connection therewith, the Company shall not be required to name such Departing
Designee on its proxy statement or solicit votes in favor of such Departing Designee.


 


(g)     
For so long as the Investor holds the applicable threshold percentages set forth in Section 4(b), in the event that
any member of the Board other than the Company’s Chief Executive Officer serves on the board of directors or similar governing
body of any Subsidiary of the Company (a “Subsidiary Board”) or in the event that any stockholder of the Company
has appointed or designated a person to serve on a Subsidiary Board, the Investors shall be entitled to designate a number of Investor
Designees to the Subsidiary Board equal to the greater of (x) one Investor Designee or (y) such other number of Investor Designees
such that the proportionate representation of Investor Designees on such Subsidiary Board approximates, as closely as possible,
the proportionate representation of Investor Designees on the Board.


 


(h)    
Subject to applicable law and listing requirements, the Investor Designees shall be entitled to be a member of any committee
of the Board (including an executive or similar committee).


 


(i)       Notwithstanding
any other provision of this Agreement, Section 4 shall terminate upon an assignment or transfer pursuant to Section 6(c); provided,
however, that this Section 4(i) shall not apply if such transfer or assignment is to an Affiliate of the Purchaser.


 


		5.	Information and Confidentiality.



 









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(a)    
For so long as Purchaser has the right to designate a director to the Board pursuant to this Agreement, the Company shall,
and shall cause its Subsidiaries to, afford to Purchaser and its Representatives reasonable access, during normal business hours,
in such manner as to not interfere with the normal operation of the Company and its Subsidiaries, to their respective properties,
books, contracts, commitments, Tax Returns, records and appropriate officers and employees, and shall furnish Purchaser and its
Representatives with financial and operating data and other information concerning the affairs of the Company and its Subsidiaries,
in each case, as Purchaser and its Representatives may reasonably request; provided, that such access shall only be upon
reasonable advance notice. In furtherance, and not in limitation of the foregoing, for so long as Purchaser owns any Company Common
Stock or Warrants, the Company shall provide to Purchaser all information and documentation reasonably requested by Purchaser,
within the periods reasonably requested by Purchaser, as is necessary for the Purchaser to complete and file all public filings
required to be made by Purchaser under applicable Law and the rules and regulations of the Securities Exchange Commission.


 


(b)     The Purchaser agrees that it will keep confidential and will not
disclose or divulge any confidential information obtained from the Company pursuant to the terms of this Agreement, unless such
confidential information (a) is known or becomes known to the public in general (other than as a result of a breach of this Section
5 by the Purchaser), (b) is or has been independently developed or conceived by the Purchaser without use of the Company’s
confidential information, or (c) is or has been made known or disclosed to the Purchaser by a third party without a breach of any
obligation of confidentiality such third party may have to the Company; provided, however, that the Purchaser may disclose confidential
information (i) to its attorneys, accountants, consultants and other professionals to the extent necessary to obtain their services
in connection with matters related to the Company; (ii) to any prospective purchaser of any Registrable Securities from the Purchaser,
if such prospective purchaser agrees to be bound by the provisions of this Section 5; (iii) to any Affiliate or its or their
general or limited partners, members, stockholders, employees, officers or directors, in the ordinary course of business, provided
that the Purchaser informs such person that such information is confidential and directs such person to maintain the confidentiality
of such information; or (iv) as may otherwise be required by law, regulation, rule, court order, arbitration order or subpoena,
provided that the Purchaser promptly notifies the Company of such disclosure and takes reasonable steps to minimize the extent
of any such required disclosure. The Purchaser acknowledges and agrees that the securities laws of the United States and other
jurisdictions contain prohibitions on the trading in the securities of the Company while in possession of material nonpublic
information regarding the Company, and agrees to comply with such restrictions.


 


		6.	Miscellaneous.



 


(a)    
Amendments and Waivers. This Agreement may be amended only by a writing signed by the Company and the Purchaser.
The failure or delay in enforcing compliance at any time with respect to any of the provisions, terms or conditions of this Agreement
shall not be considered a waiver of such provision, term or condition itself or of any of the other provisions, terms or conditions
hereof.


 


(b)     
Notices. All notices and other communications provided for or permitted hereunder shall be made as set forth in Section 9.1
of the Purchase Agreement.


 









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(c)     
Assignments and Transfers by the Purchaser. The provisions of this Agreement shall be binding upon and inure to the
benefit of the parties and their respective successors and permitted assigns. The Purchaser may transfer or assign, in whole or
from time to time in part, to one or more persons its rights hereunder in connection with the transfer of Registrable Securities
by the Purchaser to such person, provided that the Purchaser complies with all laws applicable thereto and the provisions of the
Purchase Agreement and the Warrant and provides written notice of assignment to the Company prior to such assignment or transfer
being effected, and such transferee agrees in writing and as a condition to the receipt of Registrable Securities to be bound by
all of the provisions contained herein.


 


(d)    
Assignments and Transfers by the Company. This Agreement may not be assigned by the Company (whether by operation
of law or otherwise) without the prior written consent of the Purchaser; provided, however, that in the event that
the Company is a party to a merger, consolidation, share exchange or similar business combination transaction in which the Company
Common Stock are converted into the equity securities of another person, from and after the effective time of such transaction,
such person shall, by virtue of such transaction, be deemed to have assumed the obligations of the Company hereunder, and the term
 “Company” shall be deemed to refer to such person and the term “Registrable Securities” shall be deemed
to include the securities received by the Purchaser in connection with such transaction unless such securities are otherwise freely
tradable by the Purchaser after giving effect to such transaction.


 


(e)     
Benefits of the Agreement. The terms and conditions of this Agreement shall inure to the benefit of and be binding
upon the respective successors and permitted assigns of the parties. Nothing in this Agreement, express or implied, is intended
to confer upon any party other than the parties hereto or their respective successors and permitted assigns any rights, remedies,
obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement.


 


(f)     
Counterparts. This Agreement may be executed in several counterparts, and by each party on separate counterparts,
each of which and any photocopies or other electronic transmission (including by PDF) thereof shall be deemed an original, but
all of which together shall constitute one and the same agreement.


 


(g)     Titles
and Subtitles. The titles and subtitles used in this Agreement are used for convenience only and are not to be considered
in construing or interpreting this Agreement.


 


(h)   
Severability. Any provision of this Agreement that is prohibited or unenforceable in any jurisdiction shall, as to
such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions
hereof but shall be interpreted as if it were written so as to be enforceable to the maximum extent permitted by applicable law,
and any such prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in
any other jurisdiction. To the extent permitted by applicable law, the parties hereby waive any provision of law which renders
any provisions hereof prohibited or unenforceable in any respect.


 


(i)       Further
Assurances. The parties shall execute and deliver all such further instruments and documents and take all such other
actions as may reasonably be required to carry out the transactions contemplated hereby and to evidence the fulfillment of
the agreements herein contained.


 






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(j)     
Entire Agreement. This Agreement is intended by the parties as a final expression of their agreement and intended
to be a complete and exclusive statement of the agreement and understanding of the parties hereto in respect of the subject matter
contained herein. This Agreement supersedes all prior agreements and understandings between the parties with respect to such subject
matter.


 


(k)    
Specific Performance. Without limiting remedies that may be available at law or in equity, the parties acknowledge
that any failure by any party to comply with their respective obligations under this Agreement would result in material irreparable
injury to the other party for which there is no adequate remedy at law, that it will not be possible to measure damages for such
injuries precisely and that, in the event of any such failure, the non-breaching party may specifically enforce the breaching party’s
obligations under this Agreement without the need to show actual damages and without the need to post a bond or other security.


 


(l)      
Governing Law; Consent to Jurisdiction; Waiver of Jury Trial. This Agreement shall be governed by and construed in
accordance with the internal laws of the State of Delaware without regard to the choice of law principles thereof. Each Party agrees
that all legal proceedings concerning the interpretations, enforcement and defense of the transactions contemplated by this Agreement
(whether brought against a party hereto or its respective Affiliates, directors, officers, shareholders, employees or agents) shall
be commenced exclusively in the state and federal courts sitting in the State of Delaware. Each party hereby irrevocably submits
to the exclusive jurisdiction of such courts for the adjudication of any dispute hereunder or in connection herewith or with any
transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit, action
or other proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action
or proceeding is improper or is an inconvenient venue for such proceeding. Each party hereby irrevocably waives personal service
of process and consents to process being served in any such suit, action or other proceeding by mailing a copy thereof via registered
or certified United States mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices
to it under this Agreement and agrees that such service shall constitute good and sufficient service of process and notice thereof.
Nothing contained herein shall be deemed to limit in any way any right to serve process in any other manner permitted by law. The
Parties hereby waive all rights to a trial by jury.


 


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IN WITNESS WHEREOF,
the parties have executed this Agreement or caused their duly authorized officers to execute this Agreement as of the date first
above written.


 


	 	COMPANY:
	 	ENTASIS
    THERAPEUTICS HOLDINGS INC.
	 	 
	 	By:	/s/
    Manoussos Perros, Ph.D.
	 	Name:  Manoussos Perros, Ph.D.
	 	Title:    CEO




 


	 	PURCHASER:
	 	Innoviva,
    Inc.
	 	 
	 	By: 	/s/ Geoffrey Hulme
	 	Name: Geoffrey Hulme
	 	Title:   Interim Principal Executive
    Officer




 


[Signature Page to Investor Rights Agreement]