UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549




FORM 20-F/A
Amendment No. 1



(Mark One)



| | ☐ | REGISTRATION
                                         STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934
| | - | ---------------------------------------------------------------------------------------------------------------------------------------



OR

| | ☒ | ANNUAL
                                         REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the fiscal year ended December 31, 2016
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------



OR

| | ☐ | TRANSITION
                                         REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the transition period from to .
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------



OR

| | ☐ | SHELL
                                         COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934Date of event requiring this shell company report
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Commission
file number: 	001-36826

Advanced
Accelerator Applications S.A.(Exact name of Registrant as specified in its charter)

France(Jurisdiction of incorporation or organization)

20 rue
Diesel01630 Saint Genis Pouilly, France(Address of principal executive offices)Heinz Mäusli+33 (0) 4 50 99 30 70(Name, Telephone, E-mail and/or Facsimile number and Address of Company Contact Person) Copies to:

John CrowleyDavis Polk & Wardwell LLP450 Lexington AvenueNew York, NY 10017



Securities
registered or to be registered pursuant to Section 12(b) of the Act:

|Title
        of each class                                                                    | Name
        of each exchange on which registered
|---------------------------------------------------------------------------------------------- | -------------------------------------------------
|American
    Depositary Shares, each representing 2 Ordinary Shares, par value €0.10 per share | The NASDAQ
    Global Select Market              
|Ordinary
    Shares, par value €0.10 per share                                                 | The NASDAQ
    Global Select Market*             



*	Not listed for trading, only
in connection with the listing of the American Depositary Shares on The NASDAQ Global Select Market.



Securities registered or to be registered
pursuant to Section 12(g) of the Act:

None



Securities for which there is a reporting
obligation pursuant to Section 15(d) of the Act:

None



Indicate the number of outstanding shares of each of the issuer’s
classes of capital or common stock as of the close of the period covered by the annual report: 87,952,657 Ordinary Shares,
par value €0.10 per share.



Indicate by check mark if the registrant is a well-known seasoned
issuer, as defined in Rule 405 of the Securities Act.

Yes ☐	          No
☒



If this report is an annual or transition report, indicate
by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act
of 1934.

Yes ☐	          No
☒



Note – Checking the box above will not relieve
any registrant required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 from their obligations
under those Sections.



Indicate by check mark whether the registrant (1) has filed
all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months
(or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements
for the past 90 days.

Yes ☒	          No
☐



If applicable, place an X in the box to designate the appropriate
rule provision relied upon in conducting this transaction:

Exchange Act Rule 13e-4(i) (Cross-Border
Issuer Tender Offer) ☐
Exchange Act Rule 14d-1(d) (Cross-Border Third-Party Tender Offer) ☐



Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, or a non-accelerated filer. See definition of “accelerated filer and large accelerated filer”
in Rule 12b-2 of the Exchange Act. (Check one):

|Large Accelerated Filer  ☒ | Accelerated Filer  ☐ | Non-accelerated Filer  ☐
|-------------------------- | -------------------- | ------------------------



Indicate by check mark which basis of accounting the registrant
has used to prepare the financial statements included in this filing:

|☐U.S. GAAP | ☒International Financial Reporting Standards as issued by the International Accounting Standards Board | ☐Other
|---------- | ------------------------------------------------------------------------------------------------------ | ------













If “Other” has been checked in response to the
previous question, indicate by check mark which financial statement item the registrant has elected to follow.

☐
Item 17          	☐ Item 18



If this is an annual report, indicate by check mark whether
the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).

Yes ☐	          No
☒



(APPLICABLE ONLY TO ISSUERS INVOLVED IN BANKRUPTCY PROCEEDINGS
DURING THE PAST FIVE YEARS)



Indicate by check mark whether the registrant has filed all
documents and reports required to be filed by Sections 12, 13 or 15(d) of the Securities Exchange Act of 1934 subsequent to the
distribution of securities under a plan confirmed by a court.

Yes
☐	          No ☐




















EXPLANATORY NOTE



This Amendment No. 1 on Form 20-F/A (this “Amendment”)
amends the Annual Report on Form 20-F for the year ended December 31, 2016 of Advanced Accelerator Applications S.A. (the “Company”),
as originally filed with the U.S. Securities and Exchange Commission on March 29, 2017 (the “original Form 20-F”).
This Amendment is prepared for the purpose of responding to comments from
the Staff of the U.S. Securities and Exchange Commission in connection with its review of the original Form 20-F. The Company is
filing this Amendment to include additional exhibits under “Item 19. Exhibits” of the original Form 20-F, and to file
updated certifications pursuant to section 302 of the Sarbanes-Oxley Act of 2002 as exhibits 12.1 and 12.2. Pursuant to Rule 12b-15
promulgated under the Securities Exchange Act of 1934, as amended, new certifications of the Company’s Chief Executive Officer
and Chief Financial Officer are also being filed with this Amendment as exhibits 13.1 and 13.2, respectively. Other than as expressly
set forth above, this Amendment does not, and does not purport to, revise, update, amend or restate the information presented in
any Item of the original Form 20-F or reflect any events that have occurred after the filing of the original Form 20-F. Accordingly,
this Amendment should be read in conjunction with the original Form 20-F and any documents filed with or furnished to the U.S.
Securities and Exchange Commission by the Company subsequent to March 29, 2017.











ITEM 19. EXHIBITS



|Exhibit
No. | Description                                                                                                                                                                                                                                                                                                                                                     
|----------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|1.1         | English Translation of Articles of Association (entry into force on March 3, 2017).*                                                                                                                                                                                                                                                                            
|2.1         | Form of Deposit Agreement among Advanced Accelerator Applications S.A., The Bank of New York Mellon, as depositary, and owners and holders of American Depositary Shares (incorporated herein by reference to our Registration Statement on Form F-6 (File No. 333-201502) filed with the SEC on January 14, 2015).                                             
|2.3         | Form of American Depositary Receipt (included in Exhibit 4.1).                                                                                                                                                                                                                                                                                                  
|2.4         | Form of Shareholders’ Agreement (incorporated herein by reference to Exhibit 4.3 to the Company’s Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015).                                                                                                                                                              
|2.5         | Form of Warrant Subscription (incorporated herein by reference to Exhibit 10.12 to the Company’s Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015).                                                                                                                                                               
|4.1         | Advanced Accelerator Applications S.A. 2016 Warrant Plan (incorporated herein by reference to Exhibit 99.1 to the Company’s Registration Statement on Form S-8 (File No. 333-213733) filed with the SEC on September 21, 2016).                                                                                                                                 
|4.2         | Advanced Accelerator Applications S.A. 2015 Stock Option Plan (incorporated herein by reference to Exhibit 10.11 to the Company’s Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015).                                                                                                                              
|4.3         | Advanced Accelerator Applications S.A. 2013 Free Share Plan (incorporated herein by reference to Exhibit 99.3 to the Company’s Registration Statement on Form S-8 (File No. 333-213733) filed with the SEC on September 21, 2016).                                                                                                                              
|4.4         | Advanced Accelerator Applications S.A. 2010 Free Share Plan (incorporated herein by reference to Exhibit 99.4 to the Company’s Registration Statement on Form S-8 (File No. 333-213733) filed with the SEC on September 21, 2016).                                                                                                                              
|4.5         | Service Agreement, dated April 3, 2012, between Advanced Accelerator Applications S.A. and Pierrel Research Italy S.p.A (incorporated herein by reference to Exhibit 10.6 to the Company’s Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015).                                                                     
|4.6         | Letter Agreement, dated September 2, 2016, between Advanced Accelerator Applications SA and Accelovance Europe S.r.l.*                                                                                                                                                                                                                                          
|4.7         | Letter Agreement, dated November 8, 2016, between Accelovance Europe S.r.l. and Advanced Accelerator Applications S.A.*                                                                                                                                                                                                                                         
|4.8         | Unanimous Shareholders Agreement dated March 27, 2014, among Advanced Accelerator Applications Canada Inc., 4549694 Canada Inc., 7329563 Canada Inc. and Atreus Pharmaceuticals Corporation (incorporated herein by reference to Exhibit 10.7 to the Company’s Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015).†
|4.9         | Share Purchase Agreement dated December 18, 2014 between 7329563 Canada Inc. and Advanced Accelerator Applications S.A. (incorporated herein by reference to Exhibit 10.8 to the Company’s Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015).†                                                                    
|4.10        | Agreement on Special Compensation Allowance by and between Advanced Accelerator Applications S.A. and Claudio Costamagna dated January 19, 2015 (incorporated herein by reference to Exhibit 1.1 to the Company’s Amendment No. 1 to Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on November 2, 2015).                          
|4.11        | License Agreement, dated June 16, 2015 between Advanced Accelerator Applications International and Fujifilm RI Pharma Co., Ltd (incorporated herein by reference to Exhibit 10.10 to the Company’s Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015).†                                                            





4







|Exhibit
No. | Description                                                                                                                                                                                                                                                                                                                                                           
|----------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|4.12        | Sale and Purchase Agreement, dated May 20, 2010, by and among Advanced Accelerator Applications S.A., BioSynthema Inc., and certain shareholders of BioSynthema Inc. listed in Schedule 1 thereto (incorporated herein by reference to Exhibit 10.2 to the Company’s Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015).†
|4.13        | License Agreement, dated October 10, 2007, by and between Mallinckrodt Inc. and BioSynthema Inc. (incorporated herein by reference to Exhibit 10.3 to the Company’s Registration Statement on Form F 1 (File No. 333-207223) filed with the SEC on October 1, 2015).†                                                                                                 
|4.14        | Know How and Trademark License Agreement, dated January 14, 2009, between Advanced Accelerator Applications S.A. and IASON GmbH (incorporated herein by reference to Exhibit 10.4 to the Company’s Registration Statement on Form F 1 (File No. 333-207223) filed with the SEC on October 1, 2015).†                                                                  
|4.15        | License Agreement, dated June 12, 2007 (incorporated herein by reference to Exhibit 10.5 to the Company’s Registration Statement on Form F 1 (File No. 333-207223) filed with the SEC on October 1, 2015).†                                                                                                                                                           
|8.1         | List of subsidiaries (incorporated herein by reference to Exhibit 21.1 to the Company’s Registration Statement on Form F-1 (File No. 333-207223) filed with the SEC on October 1, 2015).                                                                                                                                                                              
|12.1        | Certification pursuant to section 302 of the Sarbanes-Oxley Act of 2002.**                                                                                                                                                                                                                                                                                            
|12.2        | Certification pursuant to section 302 of the Sarbanes-Oxley Act of 2002.**                                                                                                                                                                                                                                                                                            
|13.1        | Certification pursuant to 18 U.S.C. section 1350, as adopted pursuant to section 906 of the Sarbanes Oxley Act of 2002.**                                                                                                                                                                                                                                             
|13.2        | Certification pursuant to 18 U.S.C. section 1350, as adopted pursuant to section 906 of the Sarbanes Oxley Act of 2002.**                                                                                                                                                                                                                                             
|15.1        | Consent of KPMG SA.**                                                                                                                                                                                                                                                                                                                                                 










| | * | Filed with the original Form 20-F and incorporated by
reference therefrom.
| | - | --------------------------------------------------------------------------



| | ** | Filed with this Annual Report on Form 20-F/A.
| | -- | ---------------------------------------------



| | † | Confidential treatment requested as to portions of the
exhibit. Confidential materials omitted and filed separately with the Securities and Exchange Commission.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------



5







SIGNATURES



The registrant hereby certifies that it
meets all of the requirements for filing on Form 20-F/A and that it has duly caused and authorized the undersigned to sign this
annual report on its behalf.



| | ADVANCED ACCELERATOR APPLICATIONS S.A.
| | --------------------------------------
| |                                       
| |                                       
| | By:                                   
| |                                       
| |                                       
| |                                       



Date: July 17, 2017



6