August
20, 2010





Ms. Judy
Brown, Contracts Manager


Office of
Research


University
of Waterloo


200
University Avenue West


Waterloo,
Ontario, Canada N2L 3G1





Re:
              Amendment
      to Extension and Amendment to Budget and Research Agreement between
      Waterloo, Thompson, and Senesco for a Three Month Period From September 1,
      2010 Through November 30,
2010





Dear Ms.
Brown:





Pursuant
to the Research Agreement effective September 1, 1998 (the “Agreement”), copy
attached, between the University of Waterloo (“Waterloo”), Dr. John E. Thompson
(“Thompson”), and Senesco, Inc. (“Senesco”), Waterloo, Thompson and Senesco
hereby agree to extend the Agreement for an additional three month term,
effective September 1, 2010 through November 30, 2010, under the same terms and
conditions provided in the Agreement, except that the parties hereby amend the
Budget set forth in the Revised Budget for Year 12, effective September 1, 2009,
to the amended Revised Budget for Year 13 , attached hereto, effective September
1, 2010 through November 30, 2010.  The Amended Revised Budget for
Year 13 supercedes and replaces the Revised Budget for Year 12 of the Agreement
for all work commencing on or after September 1, 2010.





Very
      truly yours,/s/
      Leslie
      J. BrowneLeslie
      J. BrownePresidentSenesco,
      Inc.





Agreed
      and Accepted:/s/
      University
      of WaterlooUniversity
      of Waterloo/s/
      Dr.
      John Thompson, Ph.D.Dr.
      John Thompson, Ph.D.









REVISED
BUDGET


YEAR
13





PERIOD: September
1, 2010 – November 30, 2010





Salaries
                                                    
                                                    Cdn $/Month
                                                    
                                                    
                                                    Cdn $/3 MonthsSenior
      Research Associate
                                                    
                                                    $
                                                    8,145.83
                                                    
                                                    
                                                    $
                                                    24,437.00($85,000/year
      + 15% benefits)Senior
      Research Associate
                                                    
                                                    
                                                    7,666.67
                                                    
                                                    
                                                    
                                                    23,000.00($80,000/year
      + 15% benefits)Research
      Associate
                                                    
                                                    
                                                    4,312.50
                                                    
                                                    
                                                    
                                                    12,938.00($45,000/year
      + 15% benefits)Research
      Associate
                                                    
                                                    
                                                    4,312.50
                                                    
                                                    
                                                    
                                                    12,938.00($45,000/year
      + 15% benefits)Research
      Associate
                                                    
                                                    
                                                    3,833,33
                                                    
                                                    
                                                    
                                                    11,500.00($40,000/year
      + 15% benefits)Research
      Associate
                                                    
                                                    
                                                    1,916,67
                                                    
                                                    
                                                    
                                                    5,750.00($20,000/year
      + 15% benefits)Research
      Associate
                                                    
                                                    
                                                    1,916,67
                                                    
                                                    
                                                    
                                                    5,750.00($20,000/year
      + 15% benefits)SuppliesOperating
      Expenses
                                                    
                                                    
                                                    10,000.00
                                                    
                                                    
                                                    
                                                    30,000.00Subtotal
                                                    
                                                    
                                                    42,104.17
                                                    
                                                    
                                                    
                                                    126,313.00Overhead30%
      on total direct costs
                                                    
                                                    
                                                    12,631,25
                                                    
                                                    
                                                    
                                                    37,894.00TOTAL
      BUDGET
                                                    
                                                    $
                                                    54,735,42
                                                    
                                                    
                                                    $
                                                    164,207.00