FORM 10-Q
                                
               SECURITIES AND EXCHANGE COMMISSION
                      Washington, DC  20549
                                
     QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                 SECURITIES EXCHANGE ACT OF 1934
                                
          For the quarterly period ended June 30, 1997
                                
                 Commission File Number  0-23666


                          TRIPOS, INC.
     (Exact Name of Registrant as Specified in its Charter)
                                
     Utah                                 43-1454986
(State or Other Jurisdiction of          (I.R.S.Employer
Incorporation or Organization)            Identification No.)


                     1699 South Hanley Road
                   St. Louis, Missouri  63144
      (Address of Principal Executive Offices and Zip Code)
                                
                                
                         (314) 647-1099
      (Registrant's Telephone Number, Including Area Code)
                                
                                

Indicate  by check mark whether the registrant (1) has filed  all
reports  required  to be filed by Section  13  or  15(d)  of  the
Securities  Exchange Act of 1934 during the preceding  12  months
(or  for such shorter period that the registrant was required  to
file  such  reports),  and (2) has been subject  to  such  filing
requirement for the past 90 days.

Yes  X              No

Number  of  shares outstanding of the issuer's Common Stock,  par
value $.01 per share, as of June 30, 1997:  3,090,731 shares.

                                
                                
                        TABLE OF CONTENTS
                                
                                
                                
PART I  FINANCIAL INFORMATION, Item 1.  Financial         Page
Statements (Unaudited)

  Consolidated Balance Sheets at
     June 30, 1997 and December 31, 1996                   3

  Consolidated Statements of Operations
  for Three Months Ended June 30, 1997 and June 30, 1996
  and Six Months Ended June 30, 1997 and June 30, 1996     4

  Consolidated Statements of Cash Flows for Six Months
  Ended June 30, 1997 and June 30, 1996                    5

  Notes to Consolidated Financial Statements               6



PART I  FINANCIAL INFORMATION,  Item 2. Management's
Discussion and Analysis of Financial Condition and Results of
Operations                                                 7



PART II  OTHER INFORMATION                                10

SIGNATURES                                                11

EXHIBITS - Exhibit 27, Financial Data Schedule
                                
                             PART I
                      FINANCIAL INFORMATION
                                
Item 1.  Financial Statements.
               CONSOLIDATED BALANCE SHEETS
                         (In thousands)
                         (Unaudited)
                                         June 30,     Dec 31,
                                             1997        1996
                           ASSETS
Current Assets:                                         
 Cash and cash equivalents               $  6,419    $  5,393
 Investments                                3,114       3,335
 Accounts receivable                        7,455      10,558
 Prepaid expenses                             426         496
 Deferred income taxes                        121         118
    Total current assets                 $ 17,535    $ 19,900
                                                        
Notes Receivable                            1,674           0
Property and equipment,                                      
     less accumulated depreciation          1,264       1,163
Capitalized development costs,                               
     less accumulated amortization          3,304       3,130
Other, net                                    684         316
                                                        
 Total assets                            $ 24,461    $ 24,509
                                                        
            LIABILITIES AND SHAREHOLDERSO EQUITY
                                                        
Current Liabilities:                                    
 Accounts payable                         $   760    $    845
 Accrued expenses                           3,679       5,306
 Deferred revenue                           4,122       3,389
    Total current liabilities               8,561       9,540
                                                        
 Deferred income taxes                        774         602
                                                             
Shareholders' equity:                                        
 Common stock                                  31          30
 Additional paid-in capital                15,581      15,220
 Accumulated deficit                        (827)      (1,382)
 Cumulative translation adjustment            341         499
                                              
    Total shareholders equity              15,126      14,367
                                                              
 Total liabilities and                   $ 24,461    $ 24,509
 shareholders equity

See accompanying notes.
                                                                 
Item 1.  Financial Statements (continued)


                   CONSOLIDATED STATEMENTS OF OPERATIONS
                   (In thousands, except per share data)
                                (Unaudited)

                            Three Months Ended      Six Months Ended
                           June 30,   June 30,    June 30,   June 30, 
                           1997       1996        1997         1996
Net sales:                                                   
   Software licenses         $ 1,853    $ 2,293      $ 3,921    $ 4,220
   Support                     1,783      1,635        3,529      3,220
   Accelerated discovery       1,448      1,291        3,795      1,838
    services
   Hardware                    1,267      1,600        1,898      2,328
                                         
Total net sales                6,351      6,819       13,143     11,606
                                                                       
Operating costs and                                                    
expenses:
   Cost of sales               2,375      2,511        4,699      4,138
   Sales and marketing         2,146      2,630        4,674      4,991
   Research and                  969        817        2,004      1,621
    development
   General and                   346        407        1,135        758
    administrative                                         
Total costs and expenses       5,836      6,365       12,512     11,508
                                                                       
Income from operations           515        454          631         98
                                                                       
Other income, net                112         39          266        127
                                 
                                                                       
Income before income             627        493          897        225
 taxes
                                                                       
Income tax expense               240         96          342         52
                                 
                                                                       
Net income                   $   387     $  397      $   555     $  173
                                                                       
Earnings per common and                                                
   common equivalent share   $  0.11     $ 0.13      $  0.16     $ 0.05
                                                                       
Weighted average number                                                
  of common and common         3,457      3,154        3,472      3,145
  equivalent shares

See accompanying notes.

Item 1.  Financial Statements (continued)

              CONSOLIDATED STATEMENTS OF CASH FLOWS
                         (In Thousands)
                           (Unaudited)


                                               Six Months Ended
                                               June 30,   June 30,
                                                   1997       1996
 Cash flows from operating activities                        
    Net income                                  $   555    $   173
    Adjustments to reconcile net income                           
    to net cash provided by operating
    activities:
       Depreciation of property and                 318        317
        equipment
       Amortization of capitalized                1,461      1,465
        development costs
       Deferred income taxes                        169         29
    Change in operating assets and                                
    liabilities:
       Accounts receivable                        2,816        580
       Notes receivable                          (1,674)         0
       Prepaid expenses and other                    79         17
       assets
       Accounts payable and accrued             (1,461)        438
       expenses
       Deferred revenue                             806         64
                                                    
 Net cash provided by operating                   3,069      3,083
 activities
                                                             
 Cash flows from investing activities:                            
    Net purchases, sales, and                       221      (112)
     maturities of investments
    Purchases of property and equipment           (431)      (360)
    Capitalized development costs               (1,758)    (2,316)
    Other                                         (293)      (300)
 Net cash used in investing activities          (2,261)    (3,088)
                                                                  
 Cash flows from financing activities:                            
    Stock issuance pursuant to stock plans         449        151

 Net cash provided by financing                    449        151
 activities
                                                                  
 Effect of foreign exchange rate changes on                          
 cash and cash equivalents                        (231)       (11)
    and cash equivalents                          
                                                                  
 Net increase in cash and cash                   1,026        135
 equivalents
                                                                  
 Cash and cash equivalents at beginning          5,393      3,955
 of period
                                                                  
 Cash and cash equivalents at end of           $ 6,419    $ 4,090
 period

See accompanying notes.

Item 1.  Financial Statements (continued)
                                
                                
           NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                           (Unaudited)


(1)  Summary of significant accounting policies

     (a)  Organization

      Tripos,  Inc.  (the  "Company") delivers science,  tools  and
analysis   services   that   advance  customers'   creativity   and
productivity  in  pharmaceutical, agrochemical,  biotechnology  and
related research industries worldwide.  The Company is also a value-
added reseller of third party hardware products required to operate
its  software  products.  A substantial portion  of  the  Company's
business  is conducted with pharmaceutical companies, however,  the
Company is not economically dependent on any customer on an ongoing
basis.


     (b)  Basis of Presentation

      The  accompanying unaudited consolidated financial statements
have been prepared in accordance with generally accepted accounting
principles   for  interim  financial  information  and   with   the
instructions  to  Form  10-Q  and Article  10  of  Regulation  S-X.
Accordingly,  they  do  not  include all  of  the  information  and
footnotes required by generally accepted accounting principles  for
complete  financial statements.  In the opinion of management,  all
normal  recurring adjustments necessary for a fair presentation  of
such  financial  statements have been included.  Operating  results
for  the  three and six month periods ended June 30, 1997  are  not
necessarily indicative of the results that may be expected for  the
year ended December 31, 1997.


(2)  Income taxes

     The provision for income taxes is computed using the liability
method.   The  primary difference between financial  statement  and
taxable  income results primarily from the use of different methods
of  computing  capitalized development costs, accrued vacation  and
customer deposits.

Item 2.  Management's Discussion and Analysis of Financial
Condition and Results of Operations

Overview

       The   CompanyOs   quarterly  operating  results   can   vary
significantly   depending  upon  such  factors   as   the   capital
expenditure  budgets  of  its  customers,  lengthy  sales   cycles,
selection  of compounds from our chemical compound library,  market
acceptance  of  new  products  and enhanced  versions  of  existing
products,  the timing of new product introductions by  the  Company
and  other vendors, changes in pricing policies by the Company  and
other  vendors,  and  changes in general economic  and  competitive
conditions.   In addition, a substantial portion of  the  CompanyOs
revenues for each quarter is  attributable  to a limited number of 
orders  and  tends  to  be realized towards the end of each quarter.
Thus, even short  delays or deferrals of sales near the end of a 
quarter can cause quarterly results   to   fluctuate  substantially.
The  Company   typically experiences greater gross margins on software
licenses, consulting, and  compound  sales  than  on sales of  hardware.
The  Company's profitability depends in part on the mix of its revenue
components and not necessarily on total revenues.

     Except for the historical information and statements contained
in  Management's Discussion and Analysis of Financial Condition and
Results of Operations ("MD&A"), the matters and items contained  in
this  document,  including  MD&A, contain  certain  forward-looking
statements  that  involve uncertainties and risks.   The  Company's
future results could differ materially from those discussed in this
doucment.   Factors  that  could  cause  a  contribution  to   such
differences,  include, but are not limited to, those  presented  in
the Company's Form 10-K for the year ended December 31, 1996.

Results of Operations

      Net  sales   for the second quarter of 1997 were $6.4 million
compared  with $6.8 million for the second quarter  of  1996.   The
overall  decrease  in net sales for the quarter was  attributed  to
decreases  in  software license and hardware sales being  partially
offset  by increases in accelerated discovery services and software
support  sales.  Overall, the Company received orders in excess  of
$8.0  million  in the current three-month period compared  to  $6.9
million in the same period in 1996.  A backlog was created at  June
30,  1997  of  approximately $1.6 million that is  expected  to  be
shipped  in the third and fourth quarters of 1997.  Net  sales  for
the  first six months of 1997 were $13.1 million compared to  $11.6
million  for  the same period in 1996.  Increases were achieved  in
accelerated  discovery services and software  support  sales  while
software  license and hardware sales decreased  in  the  six  month
period.

      For  the  three months ended June 30, 1997, software licenses
sales decreased 19.2% to $1.9 million. For the first six months  of
1997,  software  license  sales  decreased  7.1%  to  $3.9  million
compared to the same period for 1996.  The decreases are due to the
inclusion  of  two  large  orders in the second  quarter  of  1996.
Support revenues for the second quarter of 1997 increased 9.0% from
the  same  period in 1996.  Support sales increased  9.6%  to  $3.5
million  for  the six month period ending June 30,  1997.   Support
revenue increased due to a larger installed base of customers  from
software  license  sales  in recent years  along  with  incremental
revenue  from the Company's subscription access sales.  Accelerated
discovery  services  ("ADS")  sales, exclusively  diverse  compound
libraries,   increased 12.2% to $1.4 million in the second  quarter
of 1997 and 106.5% to $3.8 million for the six months year-to-date.
The  increases in ADS revenue is due to the continuing  development
in  the Optiverse library of chemical compounds which provides  the
basis for larger sales per customer.   Hardware sales decreased  by
20.8% to $1.3 million for the second quarter 1997 in comparison  to
the  same period in 1996 due to a large order being shipped in  the
second quarter of 1996.  For the first six months of 1997, hardware
sales  decreased  18.5%  to $1.9 million compared  to  1996.   This
decrease from the prior year is also due to the large order in  the
prior year period.  Sales to existing customers represent 88.3%  of
total  revenues  for the six-month period.  For  the  same  period,
sales  of  new  products  represent 4.1% of  software  license  and
discovery service sales.

      Net  sales for the Company's activities outside North America
represented  approximately 46.1% for the first six months  of  1997
compared to 55.3% for the same period in 1996.  Net sales in Europe
decreased 16.0% for the first six months of 1997 compared  to  1996
and  accounted for 32.5% and 43.8% of net sales for the  six  month
periods  in 1997 and 1996, respectively.  Net sales in the  Pacific
Rim,  principally Japan, increased 34.9% in 1997  compared  to  the
first six months of 1996 and accounted for  13.7% and 11.5% of  net
sales for the respective periods.

     Cost of sales   for the quarter ending June 30, 1997 decreased
5.4%  to  $2.4 million and increased 13.6% to $4.7 million for  the
six  month period in 1997.  The decrease in the second quarter  was
due to the large hardware order shipping in 1996.  The increase  in
year-to-date cost of sales for 1997 compared to 1996 relates to the
additional costs from increases in diverse compound library  sales.
Cost of sales as a percent of net sales was 37.4% and 35.8% for the
three  and six month periods in 1997, and 36.8% and 35.7%  for  the
three and six month periods in 1996, respectively.

      Gross  profit   margin percentage for the second  quarter  of
1997  declined  to  62.6% from 63.2% in 1996.  For  the  first  six
months of 1997, gross margin percentage was virtually unchanged  at
64.2%  compared to 64.3% for the same period in 1996.  The decrease
for  the  quarter is attributable to a change in the sales  mix  in
that  lower  margin  revenue  sources,  specifically  hardware  and
chemical compound sales, represent a higher percentage of total net
sales in 1997 compared to 1996.

      Sales  and  marketing     expenses decreased  18.4%  to  $2.1
million for the three month period in 1997 and 6.4% to $4.7 million
for  the  six  months period.  Sales and marketing  expenses  as  a
percentage of net sales were 33.8% and 35.6% for the three and  six
month  periods in 1997 as compared to 38.6% and 43.0% for the  same
periods in 1996.  The decreases for the three and six month periods
of  1997, are due to open positions and improved efficiencies among
the sales and marketing operations.

      Research  and development    costs, including the costs  that
were  capitalized, were $1.7 million and $2.7 million for the three
month  periods in 1997 and 1996, $3.7 million and $3.6 million  for
the  six month periods, respectively and represented 26.2%,  39.1%,
27.6%  and 32.2% of net sales.  The reductions in these percentages
from  1996  to  1997  reflect development and costing  efficiencies
related   to   the  compound  library.   Research  and  development
expenses,  net of capitalized development costs, represented  15.3%
and  12.0%  of net sales for the three month periods  in  1997  and
1996,  and  15.2% and 14.0% of net sales for the six month  periods
ending June 30, 1997 and 1996, respectively.

The  expense increase as a percentage of net sales for  the  three-
month  period  is  due  to the decline in  sales.   The  percentage
increase  for  the  six-month period is due to a reduction  in  the
capitalizeable  development  costs  in  the  period.   The  Company
anticipates  that  its overall investment in new  product  research
will remain relatively constant as Tripos continues development  in
the desktop, database, diverse compound libraries and combinatorial
chemistry markets.

      General  and  administrative    expenses  decreased  to  $0.3
million for the second quarter of 1997 compared to $0.4 million  in
1996,  and  represent 5.4% and 6.0% of net sales for the respective
periods.   The  slight decline in G&A relates  to  the  booking  of
bonuses  and other reserves in the prior year.  For the  six  month
period,  G & A expenses were $1.1 million and $0.8 million in  1997
and 1996, respectively, and represent 8.6% and 6.5% of net sales in
the six-month periods.  The increase in expense for 1997 relates to
the inclusion of two departments in G&A that were recorded in Sales
and Marketing and R&D in the prior year.

     Other income (expense)    increased from income of $39,000 for
the second quarter in 1996 to income of $112,000 for the comparable
period  in  1997.  For the first six months of 1997,  other  income
(expense) was $266,000 compared to $127,000 in 1996.  These changes
were  due  to increases in foreign currency translation  gains  and
interest income on investments.

      Income tax expense   was $342,000 for the six month period in
1997  which  represents an effective tax rate of  38%  compared  to
$52,000 and 23% for the same period in 1996.  The rates reflect the
change  in  valuation  of  the Company's  prior  losses,  including
foreign  subsidiary losses.  The Company's effective tax  rate  for
the  six  months  ended  June  30, 1997  reflects  an  increase  to
approximate  the  expected effective tax rate for the  year  ending
December 31, 1997.


Liquidity, Capital Resources and Capital Commitments

      For  the  six  month period ending June 30,  1997,  net  cash
provided by operations was $3.1 million as a result of decreases in
accounts  receivable of $2.8 million and accounts payable  of  $1.5
million   along   with  increases  in  net  income,   depreciation,
amortization,  notes  receivable  and  deferred  revenue  of   $0.6
million, $0.3 million, $1.5 million, $1.7 million and $0.8 million,
respectively. Amortization of $1.2 million is attributable  to  the
cost  of  manufacturing  the  compound  library.   Increased  notes
receivable of $1.7 million are from longer term sales contracts and
a  note  arising  from  an  investment in a  private  biotechnology
company.   For  the  same  period in 1996,  net  cash  provided  by
operations  was  $3.1  million primarily  due  to  an  increase  in
depreciation,  amortization  and  accounts  payable  along  with  a
decrease in accounts receivable.

      Investments  of  $0.4  million  in  property  and  equipment,
together  with  $1.8  million  in  capitalized  development  costs,
resulted  in  a  use of cash of approximately $2.3 million  in  the
first half of 1997.

      The  Company  believes that current working capital  of  $9.0
million,  together  with continued cash from  operations,  will  be
adequate   to  fund  short-term  liquidity  requirements  including
investments in research and development, capital purchases and  any
other  commitments in the upcoming year.  The Company may  seek  to
obtain  additional  financing at any time in  connection  with  the
Company's  product development efforts and its efforts to penetrate
existing  and  new  markets for its products,  depending  upon  the
associated working capital requirements.


                             PART II
                        OTHER INFORMATION
                                
Item 1.   Legal Proceedings

          The Company is not a party to any material litigation
and is not aware of any threatened material litigation.

Item 2.   Changes in Securities

          None

Item 3.   Defaults upon Senior Securities

          None

Item 4.   Submission of Matters to a Vote of Security Holders

          The following matters were submitted to a vote of the
          shareholders of the Company at its Annual Meeting of
          Shareholders on May 9, 1997:
          
          (a)  To elect directors to serve for the ensuing year or until
            their successors are elected; and
          (b)  To amend the 1994 Stock Option plan to increase the number
            of shares reserved thereunder from 704,000 to 1,100,000

          All Directors standing for election were elected and
          the amendment to the 1994 Stock Option Plan was
          approved.

Item 5.   Other Information

          None

Item 6.   Exhibits and Reports on Form 8-K

          (a)  List of Exhibits

               Exhibit 27, Financial Data Schedule

          (b)  No reports on Form 8-K were required to be filed
               during the period from March 31, 1997 to June 30, 1997.




                          TRIPOS, INC.
                           SIGNATURES
                                
     Pursuant to the requirements of the Securities Exchange Act
of 1934, the Registrant has duly caused this report to be signed
on its behalf by the undersigned hereunto duly authorized.

                              TRIPOS, INC.


Date: August 6, 1997          John P. McAlister/s
                              John P. McAlister
                              President and
                              Chief Executive Officer


Date: August 6, 1997          Colleen A. Martin/s
                              Colleen A. Martin
                              Chief Financial Officer, Secretary