EXHIBIT 4.21







CENVEO
CORPORATION
 
 the
GUARANTORS named in Schedule I hereto
 
 and
 
 U.S. BANK
NATIONAL ASSOCIATION,
 as
Trustee
  
 FIRST
SUPPLEMENTAL INDENTURE
 Supplementing
the Indenture of
 June 13,
2008
 
  Dated as
of August 20, 2008
 
 10.5%
SENIOR NOTES DUE 2016
 
 
 
  
  THIS
FIRST SUPPLEMENTAL INDENTURE, dated as of August 20, 2008, is among Cenveo
Corporation, a Delaware corporation (the “Company”), the Guarantors (as
defined herein) listed on Schedule I hereto (each a “Guarantor” and collectively
the “Guarantors”), and
U.S. Bank National Association, as trustee (the “Trustee”).
  WHEREAS,
in connection with the issuance by the Company of its 10.5% Senior Notes due
2016 (the “Notes”), in
the aggregate principal amount of $175,000,000, the Company, the Guarantors and
the Trustee entered into an indenture dated as of June 13, 2008 (the “Indenture”); and
  WHEREAS,
Section 9.01 of the Indenture provides that the Company, the Guarantors and the
Trustee may amend or supplement the Indenture and the Notes without the consent
of any holder of any outstanding Notes; and
  WHEREAS,
the Company has authorized the execution and delivery of this First Supplemental
Indenture; and
  WHEREAS,
all things necessary to make this First Supplemental Indenture a valid agreement
of the Company, the Guarantors and the Trustee have been done.
  NOW
THEREFORE, WITNESSETH, that, for and in consideration of the premises, and in
order to comply with the terms of Section 4.14 and Article Nine of the
Indenture, the Company agrees with the Guarantors and the Trustee as
follows:
  ARTICLE
1.
 ADDITION
OF GUARANTORS
  SECTION
      1.01.
              ADDITIONAL
      GUARANTORS
  Effective
as of the Operative Date (as hereinafter defined), in accordance with the terms
of the Indenture, Lightning Labels, LLC (the “Additional Guarantor”) hereby
agrees (a) to become a Guarantor in respect of the Notes and the other
obligations of the Company guaranteed by the Guarantors pursuant to Article 10
of the Indenture, with the same force and effect as if it were an original party
to the Indenture in such capacity, (b) that each reference in the Indenture to a
“Guarantor” shall also mean and be a reference to the Additional Guarantor, and
(c) to be obligated and bound by all the terms, provisions and covenants under
the Indenture (including, without limitation, Article 10 thereof) which are
binding on a Guarantor.
  ARTICLE
2.
 MISCELLANEOUS
  SECTION
      2.01.
              OPERATIVE
      DATE
  This
First Supplemental Indenture is effective when executed (the “Operative Date”).
   
  SECTION
      2.02.
              COUNTERPART
      ORIGINALS
  The
parties may sign any number of copies of this First Supplemental
Indenture.  Each signed copy shall be an original, but all of them
together shall constitute the same agreement.
  SECTION
      2.03.
              GOVERNING
      LAW
  This
First Supplemental Indenture shall be governed by and construed in accordance
with the laws of the State of New York, without regard to its conflicts of laws
principles.
  SECTION
      2.04.
              TRUSTEE’S
      DISCLAIMER
  The
recitals contained herein shall be taken as the statements of the Company, and
the Trustee assumes no responsibility for their correctness.  The
Trustee makes no representation as to the validity or sufficiency of this First
Supplemental Indenture.
 
  
  IN
WITNESS WHEREOF, the parties hereto have caused this First Supplemental
Indenture to be duly executed, all as of the date and year first written
above.
  CENVEO
CORPORATION
  By:/s/
Mark S. Hiltwein
 Name:  Mark
S. Hiltwein
 Title:    Chief
Financial Officer
 
 
 EACH
ENTITY LISTED ON SCHEDULE
 I
HERETO
 
  By:/s/ Mark S.
Hiltwein
 Name:  Mark
S. Hiltwein
 Title:    Chief
Financial Officer
 
  U.S. BANK
NATIONAL ASSOCIATION
  
 By:/s/ John G.
Correia
 Name:  John
G. Correia
 Title:   
Vice President
 
 
  FIRST
10.5% SUPPLEMENTAL INDENTURE
  SCHEDULE
      I
 Cenveo,
Inc.
 Discount
Labels, LLC
 Cenveo
Alberta Finance LP
 Cenveo
Government Printing, Inc.
 Cenveo
Services, LLC
 McLaren
Morris & Todd Company
 MM&T
Packaging Company
 Cenveo
Commercial Ohio, LLC
 Cenveo
Resale Ohio, LLC
 Cenveo
Omemee LLC
 Colorhouse
China, Inc.
 MMTP
Holdings, Inc.
 CRX JV,
LLC
 CRX
Holding, Inc.
 Rx
Technology Corp.
 RX
      JV Holding, Inc.
 PC
      Ink Corp.
 Printegra
      Corporation
 Cadmus
      Printing Group, Inc.
 Washburn
      Graphics, Inc.
 Cadmus
      Journal Services, Inc.
 Cadmus
      Financial Distribution, Inc.
 Cadmus
      Technology Solutions, Inc.
 Garamond/Pridemark
      Press, Inc.
 Cadmus
      Delaware, Inc.
 Cadmus
      UK, Inc.
 Expert
      Graphics, Inc.
 Cadmus
      Government Publication Services,
Inc.
 Cadmus
      Marketing Group, Inc.
 American
      Graphics, Inc.
 Cadmus
      Direct Marketing, Inc.
 Cadmus
      Interactive, Inc.
 Cadmus
      Marketing, Inc.
 Cadmus/O’Keefe
      Marketing, Inc.
 Old
      TSI, Inc.
 Cadmus
      Investments, LLC
 Port
      City Press, Inc.
 Science
      Craftsman Incorporated
 Cadmus
      International Holdings, Inc.
 CDMS
      Management, LLC,
 Vaughan
      Printers Inc.
 VSUB
      Holding Company
 Madison/Graham
      ColorGraphics, Inc.
 Madison/Graham
      ColorGraphics Interstate Services,
Inc.
 Commercial
      Envelope Manufacturing Co., Inc.
 Berlin
      & Jones Co., LLC
 Heinrich
      Envelope, LLC
 Cenveo
      CEM, LLC
 Cenveo
      CEM, Inc.
 CNMW
      Investments, Inc.
 Rex
      Corporation
 136
      Eastport Road, LLC
 Lightning
      Labels, LLC