|        |
|--------|
|        |  |  |  |
| þ | Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the fiscal year ended | December 31, 2017 | or |
|  ̈ | Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from ____ to ____. |

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|----------------------------------------------------------------|
|                                                                |  |  |
| DELAWARE                                                       |   | 74-2747608 |
| (State or other jurisdiction of incorporation or organization) |   | (I.R.S. Employer Identification No.) |
| 12212 TECHNOLOGY BLVD., AUSTIN, TEXAS                          |   | 78727 |
| (Address of principal executive offices)                       |   | (Zip Code) |

|                                |
|--------------------------------|
|                                |  |  |
| Title of each class            |   | Name  of exchange on which registered |
| Common Stock, $0.001 par value |   | The Nasdaq Global Select Market |

|        |
|--------|
|        |  |  |  |
|   |         Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. |
|   |   | þ Yes |  ̈ No |
|   |   |   |   |
|   |         Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. |
|   |   |  ̈ Yes | þ No |
|   |   |   |   |
|   |         Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. |
|   |
|   |   | þ Yes |  ̈ No |
|   |   |   |   |
|   |         Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). |
|   |
|   |   | þ Yes |  ̈ No |
|   |   |   |   |
|   |         Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (§229.405 of this chapter) is not contained herein, and will not be contained, to the best of Registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K. |
|   |
|   |   |   |  ̈ |
|   |   |   |   |

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|        |
|--------|
|        |  |  |  |  |  |
|   |         Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act (Check one). |
|   |
|   |   |   |   |   |   |
|   | Large accelerated filer | þ |   | Accelerated filer |  ̈ |
|   | Non-accelerated filer |  ̈ | (Do not check if a smaller reporting company) | Smaller reporting company |  ̈ |
|   |   |   |   | Emerging growth company |  ̈ |
|   |   |   |   |   |   |

|        |
|--------|
|        |  |  |  |
|   |         If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. |
|   |
|   |   |   |  ̈ |
|   |   |   |   |
|   |        Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). |
|   |   |  ̈ Yes | þ No |

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|     |                                                                                 |
|-----|---------------------------------------------------------------------------------|
| (a) | The following documents are filed as a part of this Annual Report on Form 10-K: |

|     |                       |
|-----|-----------------------|
| (1) | Financial Statements: |

|     |                                |
|-----|--------------------------------|
| (2) | Financial Statement Schedules: |

|     |           |
|-----|-----------|
| (3) | Exhibits: |

|               |
|---------------|
|               |  |  |
| EXHIBITNUMBER |   | DESCRIPTION OF DOCUMENT |
|          |   |   |
| 2.1           |   | Agreement and Plan of Merger, dated as of May 15, 2016, among Luminex Corporation, Commodore Acquisition, Inc., and Nanosphere, Inc. (Previously filed as an Exhibit to the Company’s Current Report on Form 8-K (File No. 000-30109), filed on May 16, 2016). |
|          |   |   |
| 2.2           |   | First Amendment to the Agreement and Plan of Merger, dated as of May 22, 2016, among Luminex Corporation, Commodore Acquisition, Inc., and Nanosphere, Inc. (Previously filed as an Exhibit to the Company’s Current Report on Form 8-K (File No. 000-30109), filed on May 23, 2016). |
|          |   |   |
| 2.3           |   | Second Amendment to the Agreement and Plan of Merger, dated as of June 1, 2016, among Luminex Corporation, Commodore Acquisition, Inc., and Nanosphere, Inc. (incorporated by reference to Exhibit 2.1 to the Current Report on Form 8-K filed by Nanosphere, Inc. with the Securities and Exchange Commission on June 2, 2016). |
|          |   |   |
| 3.1           |   | Restated Certificate of Incorporation of the Company (Previously filed as Exhibit 3.1 to the Company's Registration Statement on Form S-1 (File No. 333-96317), filed February 7, 2000, as amended). |
|          |   |   |
| 3.2           |   | Amended and Restated Bylaws of the Company (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed March 11, 2015). |
|          |   |   |
| 10.1#         |   | 2000 Long-Term Incentive Plan of the Company, as amended (Previously filed as an Exhibit to the Company's Quarterly Report on Form 10-Q (File No. 000-30109) for the quarterly period ended March 31, 2002). |
|          |   |   |
| 10.2#         |   | Form of Stock Option Award Agreement for the 2000 Long-Term Incentive Plan (Previously filed as Exhibit 10.3 to the Company's Registration Statement on Form S-1 (File No. 333-96317), filed February 7, 2000, as amended). |
|          |   |   |
| 10.3#         |   | Form of Indemnification Agreement between the Company and each of the directors and executive officers of the Company (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed September 16, 2008). |
|          |   |   |
| 10.4          |   | Lease Agreement between Aetna Life Insurance Company, as Landlord, and Luminex Corporation, as Tenant, dated October 19, 2001 (Previously filed as an Exhibit to the Company's Quarterly Report on Form 10-Q (File No. 000-30109) for the quarterly period ended September 30, 2001). |
|          |   |   |
| 10.5          |   | First Amendment to Lease Agreement between Aetna Life Insurance Company, as Landlord, and Luminex Corporation, as Tenant, dated July 25, 2002 (Previously filed as an Exhibit to the Company's Quarterly Report on Form 10-Q (File No. 000-30109) for the quarterly period ended June 30, 2002). |
|          |   |   |
| 10.6          |   | Lease Amendment between McNeil 4 & 5 Investors, LP, as Landlord, and Luminex Corporation, as Tenant, dated January 27, 2003 (Previously filed as an Exhibit to the Company's Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2002). |
|          |   |   |
| 10.7          |   | Lease Agreement between PS Business Parks, L.P., as Landlord, and Luminex Corporation, as Tenant, dated September 30, 2014 (Previously filed as an Exhibit to the Company’s Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2014). |
|          |   |   |

----

|        |
|--------|
|        |  |  |
| 10.8#  |   | Employment Agreement, effective as of October 1, 2003, by and between Luminex Corporation and Harriss T. Currie (Previously filed as an Exhibit to the Company's Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2003). |
|   |   |   |
| 10.9#  |   | Luminex Corporation Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed May 21, 2009). |
|   |   |   |
| 10.10# |   | Form of Non-Qualified Stock Option Agreement for the Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed May 21, 2009). |
|   |   |   |
| 10.11# |   | Form of Restricted Share Award Agreement for Officers & Employees for the Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed May 21, 2009). |
|   |   |   |
| 10.12# |   | Form of Restricted Share Award Agreement for Directors for the Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed May 21, 2009). |
|   |   |   |
| 10.13# |   | Form of Restricted Share Unit Agreement for Officers & Employees for the Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed May 21, 2009). |
|   |   |   |
| 10.14# |   | Form of Restricted Share Unit Agreement for Directors for the Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed May 21, 2009). |
|   |   |   |
| 10.15# |   | Amendment to Luminex Corporation Amended and Restated 2000 Long-Term Incentive Plan dated as of May 24, 2007 (Previously filed as an Exhibit to the Company's Quarterly Report on Form 10-Q (File No. 000-30109) for the quarterly period ended June 30, 2007). |
|   |   |   |
| 10.16# |   | Luminex Corporation 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Proxy Statement (File No. 000-30109) for its Annual Meeting of Shareholders held on May 25, 2006). |
|   |   |   |
| 10.17# |   | Form of Non-Qualified Stock Option Agreement for the 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed May 25, 2006). |
|   |   |   |
| 10.18# |   | Form of Restricted Share Award Agreement for Officers & Employees for the 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed May 25, 2006). |
|   |   |   |
| 10.19# |   | Form of Restricted Share Award Agreement for Directors for the 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed May 25, 2006). |
|   |   |   |
| 10.20# |   | Form of Restricted Share Unit Agreement for the 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2006). |
|   |   |   |
| 10.21# |   | Form of Amendments to Equity Award Agreements (Previously filed as an Exhibit to the Company's Quarterly Report on Form 10-Q (File No. 000-30109) for the quarterly period ended June 30, 2007). |
|   |   |   |
| 10.22# |   | Luminex Corporation Second Amended and Restated 2006 Equity Incentive Plan (Previously filed as Annex A to the Company's Proxy Statement (filed with the SEC on April 3, 2012; file No. 000-30109) for its Annual Meeting of Stockholders held on May 17, 2012). |
|   |   |   |
| 10.23# |   | Luminex Corporation Employee Stock Purchase Plan (Previously filed as Annex B to the Company's Proxy Statement (filed with the SEC on April 3, 2012; file No. 000-30109) for its Annual Meeting of Stockholders held on May 17, 2012). |
|   |   |   |
| 10.24# |   | Form of Amendment to Employment Agreement, effective as of December 31, 2012, by and between Luminex Corporation and its Executives (Previously filed as an Exhibit to the Company's Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2012). |
|   |   |   |
| 10.25# |   | Employment Agreement, dated October 14, 2014, between Luminex Corporation and Nachum Shamir (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed October 20, 2014). |
|   |   |   |
| 10.26# |   | Employment Agreement, dated August 14, 2012, by and between Luminex Corporation and Nancy M. Fairchild (Previously filed as an Exhibit to the Company’s Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2014). |
|   |   |   |

----

|        |
|--------|
|        |  |  |
| 10.27# |   | Second Amendment to Employment Agreement, effective as of February 6, 2014, by and between Luminex Corporation and Nancy M. Fairchild (Previously filed as an Exhibit to the Company’s Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2014). |
|   |   |   |
| 10.28# |   | Third Amendment to Employment Agreement, effective as of January 1, 2015, by and between Luminex Corporation and Nancy M. Fairchild (Previously filed as an Exhibit to the Company’s Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2014). |
|   |   |   |
| 10.29# |   | Omnibus Amendment to the Luminex Corporation Restricted Share Unit Award Agreements (2012 and 2013 LTIPs) (Previously filed as an Exhibit to the Company’s Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2014). |
|   |   |   |
| 10.30# |   | First Amendment to the Luminex Corporation Second Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company’s Current Report on Form 8-K (File No. 000-30109), filed on March 11, 2015). |
|   |   |   |
| 10.31# |   | Form of Non-Qualified Stock Option Agreement for the Luminex Corporation Second Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company’s Quarterly Report on Form 10-Q (File No. 000-30109) for the quarterly period ended March 31, 2015). |
|   |   |   |
| 10.32# |   | Form of Stock Appreciation Rights Agreement for the Luminex Corporation Second Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company’s Quarterly Report on Form 10-Q (File No. 000-30109) for the quarterly period ended March 31, 2015). |
|   |   |   |
| 10.33# |   | Luminex Corporation Third Amended and Restated 2006 Equity Incentive Plan (Previously filed as Annex A to the Company’s Proxy Statement (filed with the SEC on March 3, 2015; file No. 000-30109) for its Annual Meeting of Stockholders held on May 14, 2015). |
|   |   |   |
| 10.34# |   | Form of Restricted Share Award Agreement for Directors for the Luminex Corporation Third Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company’s Quarterly Report on Form 10-Q (File No. 000-30109) for the quarterly period ended June 30, 2015). |
|   |   |   |
| 10.35# |   | Form of Restricted Share Unit Agreement for Directors for the Luminex Corporation Third Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company’s Quarterly Report on Form 10-Q (File No. 000-30109) for the quarterly period ended June 30, 2015). |
|   |   |   |
| 10.36# |   | Employment Agreement, dated March 4, 2015, by and between Luminex Corporation and Richard Rew (Previously filed as an Exhibit to the Company’s Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2015). |
|   |   |   |
| 10.37# |   | Employment Agreement, dated March 16, 2015, by and between Luminex Corporation and Randall Myers (Previously filed as an Exhibit to the Company's Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2016). |
|   |   |   |
| 10.38# |   | Employment Agreement, dated November 1, 2016, by and between Luminex Corporation and Todd Bennett (Previously filed as an Exhibit to the Company's Annual Report on Form 10-K (File No. 000-30109) for the fiscal year ended December 31, 2016). |
|   |   |   |
| 10.39# |   | Amended and Restated 2016 Management Incentive Plan (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed March 28, 2016). |
|   |   |   |
| 10.40# |   | Form of Performance-Based Non-Qualified Stock Option Agreement for the Luminex Corporation Third Amended and Restated 2006 Equity Incentive Plan (Previously filed as an Exhibit to the Company's Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2016). |
|   |   |   |
| 10.41# |   | First Amendment to Employment Agreement, effective March 27, 2017, by and between Luminex Corporation and Nachum Shamir (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed March 31, 2017).   |
|   |   |   |
| 10.42# |   | Amended and Restated  2017 Management Incentive Plan (Previously filed as an Exhibit to the Company's Current Report on Form 8-K (File No. 000-30109), filed March 31, 2017). |
|   |   |   |
| 10.43# |   | Amended and Restated Luminex Corporation Employee Stock Purchase Plan (Previously filed as Annex A to the Company's Proxy Statement (filed with the SEC on April 3, 2017; file No. 000-30109) for its Annual Meeting of Stockholders held on May 18, 2017). |
|   |   |   |
| 10.44# |   | Employment Agreement, dated January 1, 2018, by and between Luminex Corporation and Chuck Collins (previously filed as Exhibit 10.44# to the Original Annual Report). |
|   |   |   |
| 21.1   |   | Subsidiaries of the Company (previously filed as Exhibit 21.1 to the Original Annual Report). |
|   |   |   |

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|        |
|--------|
|        |  |  |
| 23.1   |   | Consent of Independent Registered Public Accounting Firm (previously filed as Exhibit 23.1 to the Original Annual Report). |
|   |   |   |
| 24.1   |   | Power of Attorney (previously filed as Exhibit 24.1 to the Original Annual Report). |
|   |   |   |
| 31.1   |   | Certification by CEO pursuant to Securities and Exchange Act Rules 13a-14(a) and 15d - 14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (previously filed as Exhibit 31.1 to the Original Annual Report). |
|   |   |   |
| 31.2   |   | Certification by CFO pursuant to Securities and Exchange Act Rules 13a-14(a) and 15d - 14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (previously filed as Exhibit 31.2 to the Original Annual Report). |
|   |   |   |
| 31.3*  |   | Certification by CEO pursuant to Securities and Exchange Act Rules 13a-14(a) and 15d - 14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. |
|   |   |   |
| 31.4*  |   | Certification by CFO pursuant to Securities and Exchange Act Rules 13a-14(a) and 15d - 14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. |
|   |   |   |
| 32.1   |   | Certification by CEO pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (previously filed as Exhibit 32.1 to the Original Annual Report). |
|   |   |   |
| 32.2   |   | Certification by CFO pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (previously filed as Exhibit 32.2 to the Original Annual Report). |
|   |   |   |
| 101    |   | The following materials from Luminex Corporation's Annual Report on Form 10-K for the year ended December 31, 2017, formatted in XBRL: (i) Condensed Consolidated Balance Sheets; (ii) Condensed Consolidated Statements of Comprehensive Income; (iii) Condensed Consolidated Statements of Cash Flows; and (iv) Notes to Condensed Consolidated Financial Statements. |
|   |   |   |

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