**EXHIBIT 4.2E**

**ASSIGNMENT, ASSUMPTION AND AMENDMENT AGREEMENT**

**THIS ASSIGNMENT, ASSUMPTIONAND AMENDMENTAGREEMENT**(the “***Agreement***”) is made effective as of the Effective Time, by and among **JAZZ PHARMACEUTICALS, INC.,**a Delaware corporation(“***JPI***”), **JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY**(f/k/a Azur Pharma Public Limited Company), a public limited company formed under the lawsof Ireland (“***New Jazz****”*), and the undersigned Holders (the “***Consenting Holders***”). 

**RECITALS**

**WHEREAS,** JPI and theInvestors are parties to that certain Third Amended and Restated Investor Rights Agreement made effective as of June 6, 2007 and as amended (as amended, the “***Investor Rights Agreement***”). 

**WHEREAS,**JPI, New Jazz, Jaguar Merger Sub Inc., a Delaware corporation and wholly owned subsidiaryof New Jazz (“***Merger Sub***”), and Seamus Mulligan, solely in his capacity as the representative for the Indemnitors, entered into an Agreement and Plan of Merger and Reorganization, dated as of September 19, 2011 (the“***Merger Agreement***”), pursuant to which, among other things, Merger Sub will merge with and into JPI (the “***Merger***”), with JPI as the surviving corporation in the Merger as a wholly owned subsidiary ofNew Jazz. At the Effective Time, among other things, (x) each share of the Common Stock, par value $0.0001 per share, of JPI (“***JPI Common Stock***”) then issued and outstanding will be canceled and automatically convertedinto and become the right to receive one Ordinary Share, nominal value $0.0001 per share, of New Jazz (“***New Jazz Ordinary Shares***”) and (y) each warrant to acquire JPI Common Stock outstanding as of immediately prior tothe Effective Time will be converted into a warrant to acquire the number of New Jazz Ordinary Shares equal to the number of shares of JPI Common Stock subject to such warrant immediately prior to the Effective Time, at an exercise price per NewJazz Ordinary Share equal to the exercise price per share of JPI Common Stock otherwise purchasable pursuant to such warrant. 

**WHEREAS,** the Consenting Holders acknowledge that New Jazz has entered or intends to enter into a Registration Rights Agreement in substantially the form attached as Exhibit A hereto(the “***Azur Rights Agreement***”) with the shareholders of New Jazz prior to the Merger (the “***Azur Rights Holders***”) in connection with the transactions contemplated by the Merger Agreement, pursuant towhich New Jazz is obligated to (i) prepare and file one or more registration statements (the “***Resale Registration Statements***”) under the Securities Act of 1933, as amended (the “***Securities Act***”),registering the resale of all of the New Jazz Ordinary Shares (the “***Resale Shares***”) held by the Azur Rights Holders (or any transferees or assignees thereof) on the Closing Date as set forth in Section 2.1(a) of the AzurRights Agreement and (ii) subject to certain conditions and limitations set forth therein, take certain actions to effect the issuance and sale of Resale Shares in underwritten public offerings (“***Required Underwritings***”)as set forth in Section 2.1(f) of the Azur Rights Agreement. As used in this Agreement, (x) the term “***Resale Shares***” also includes any securities issued or issuable with respect to any of the Resale Shares by way ofexchange, stock dividend or stock split or in connection with a combination of shares, recapitalization, merger, consolidation or other reorganization or otherwise; and (y) the term “***Resale Registration Statement***”includes (A) any registration statements filed by New Jazz under the Securities Act in furtherance of satisfying its obligations under the Azur Rights Agreement and (B) any amendments or supplements to any of such registration statementsor the prospectuses included therein. 

**WHEREAS,**pursuant to Section 4 of theInvestor Rights Agreement, the Holders have under certain circumstances the right to be notified if JPI decides to Register any JPI Common Stock and to include certain Registrable Securities held by such Holders in such Registration (and any related

 
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qualification under Blue Sky laws or other compliance), and in any underwriting involved therein (the “***Piggyback Registration Rights***”). 

**WHEREAS,** JPI, New Jazz and the Consenting Holders wish to enter into this Agreement for the purposeof (i) transferring the rights and obligations of JPI under the Investor Rights Agreement to New Jazz, effective as of the Effective Time (the “***Assignment***”), (ii) effecting certain waivers of rights as set forthbelow and (iii) amending the Investor Rights Agreement as set forth below. 

**WHEREAS,**the Consenting Holders are holders of at least 60% of the Registrable Securities held by all Holders and, together with JPI, have the right, pursuant to Section 15.5 of the Investor Rights Agreement, to amend the Investor Rights Agreementand to waive certain provisions thereof. 

**NOW, THEREFORE,** inconsideration of the mutual agreements, covenants and considerations contained herein, the parties hereto agree as follows: 

**AGREEMENT**

**1.     DEFINITIONS**. The term “Effective Time” shall have the meaning set forth in the Merger Agreement. Any other capitalized terms usedherein and not otherwise defined shall have the meanings set forth in the Investor Rights Agreement. 

**2.    ASSIGNMENTAND ASSUMPTION**. Effective as of the Effective Time: 

**2.1**        JPI hereby conveys, transfers and assigns to New Jazz all of JPI’s rights and obligations under the Investor Rights Agreement, as herebyamended (the “***Assignment***”). 

**2.2**        New Jazz hereby assumes the rights and agrees to perform the obligations of JPI (as “the Company” or otherwise) under the Investor Rights Agreement, as hereby amended. 

**2.3**         All references to shares of JPI Common Stock in the InvestorRights Agreement shall be deemed to be references to, as applicable, (x) with respect to shares of JPI Common Stock outstanding as of immediately prior to the Effective Time, the New Jazz Ordinary Shares into which such shares of JPI CommonStock were automatically converted at the Effective Time, (y) with respect to shares of JPI Common Stock issuable upon the exercise of warrants to purchase JPI Common Stock outstanding as of immediately prior to the Effective Time, the New JazzOrdinary Shares issuable upon exercise thereof following the Effective Time or (z) with respect to any other shares of JPI Common Stock referenced in the Investor Rights Agreement that were not outstanding immediately prior to the EffectiveTime, New Jazz Ordinary Shares. 

**3.****    CONSENTTOASSIGNMENT********. The Consenting Holders, for and on behalf of all Holders and all Investors, hereby consent to the Assignment. In connection therewith, the Consenting Holders, for and on behalf of allHolders and all Investors, hereby agree that the indemnification rights of JPI (as “the Company” or otherwise) under the Investor Rights Agreement shall be enforceable by New Jazz effective as of the Effective Time. 

**4.****    CONSENTTO AZUR RIGHTSAGREEMENT**. The Consenting Holders, for and on behalf of all Holders and all Investors, hereby consent to the entering into of the Registration Rights Agreement by New Jazz and the grant to the Azur Rights Holders ofRegistration rights pursuant thereto. 

**5.****    WAIVERS.**

 
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**5.1**        The ConsentingHolders hereby irrevocably waive, for and on behalf of all Holders and all Investors, (i) any and all Piggyback Registration Rights in connection with the filing of any Resale Registration Statement from the period beginning as of the EffectiveTime through the Deferral Date (as defined below) (the “***Deferral Period***”) and (ii) any rights to any notices with respect to the foregoing under the Investor Rights Agreement. In granting the foregoing waiver, theConsenting Holders acknowledge and understand that JPI and New Jazz currently contemplate that New Jazz will file a WKSI Shelf Registration Statement (if it is then eligible to do so) as soon as reasonably practicable following the Mergerregistering an indeterminate number of securities of New Jazz and pursuant to which New Jazz will effect the Registration of the Resale Shares (the “***Closing S-3ASR***”). For the avoidance of doubt and subject to the followingproviso, the Consenting Holders, for and on behalf of all Holders and all Investors, agree that the foregoing waiver shall also apply to the filing of the Closing S-3ASR and any supplements to the prospectus included therein solely with respect toany of the Resale Shares; *provided*, *however*, that following the Deferral Date (as defined below), the Holders may exercise their Piggyback Registration Rights to include Registrable Securities in the Closing S-3ASR or anypost-effective amendment thereto. 

**5.2**        The ConsentingHolders hereby further irrevocably waive, for and on behalf of all Holders and all Investors, on the limited basis set forth in this Section 5.2, (i) any and all Piggyback Registration Rights in connection with any Required Underwriting,the underwriting agreement for which is entered into prior to the Deferral Date (an “***Excluded Underwriting***”) and (ii) any rights to any notices with respect to any Excluded Underwriting under the Investor RightsAgreement. The waiver in this Section 5.2 is limited to Excluded Underwritings and nothing in this Agreement (including Sections 5.1 and this 5.2 hereof) shall constitute or shall be deemed to constitute a waiver of any Piggyback RegistrationRights in connection with any Required Underwriting that is not an Excluded Underwriting. 

**5.3**        The foregoing waivers in Sections 5.1 and 5.2 are irrevocable and shall be effective with respect to each Holder and each Investor, as well as all affiliates, successors, heirs, executors,administrators and assigns of each such Holder and Investor. 

**6.    DEFERRALOF REQUESTSFOR REGISTRATION**. The Consenting Holders, for and on behalf of all Holders and all Investors, hereby agreethat New Jazz shall not be obligated to effect any Registration under the Investor Rights Agreement or to include any Registrable Securities in any Registration Statement filed by New Jazz, in each case until after February 14, 2012 (such date,the “***Deferral Date***”). In furtherance of the foregoing, each Consenting Holder hereby agrees (i) not to exercise any of its rights to demand or cause New Jazz to Register any securities under the Investor Rights Agreement(including under Sections 3 and 4 thereof), or to include Registrable Securities in any Registration Statement filed by New Jazz, in each case until after the Deferral Date and (ii) not to transfer any of such Consenting Holder’sRegistration rights under the Investor Rights Agreement unless the transferee agrees in a writing, reasonably satisfactory in form and substance to New Jazz, to be bound by the terms of this Section 6 until after the Deferral Date. 

**7.     MISCELLANEOUS.**

**7.1         Full Power and Authority.**Each Consenting Holder representsand warrants to JPI and New Jazz that (i) such Consenting Holder has the full right, power and authority to execute and deliver this Agreement, and (ii) this Agreement has been duly executed and delivered by such Consenting Holder andconstitutes the legal, valid and binding obligation of such Consenting Holder enforceable in accordance with its terms, except (A) as such enforcement is limited by bankruptcy, insolvency or other similar laws affecting the enforcement ofcreditors’ rights generally and (B) for limitations imposed by general principles of equity. Each of JPI and New Jazz represent and warrant to the undersigned Holders that (i) JPI and New Jazz, as applicable, has the full right, powerand authority to execute and deliver this 

 
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Agreement, and (ii) this Agreement has been duly executed and delivered by JPI and New Jazz, as applicable, and constitutes the legal, valid and binding obligation of JPI and New Jazz, asapplicable, enforceable in accordance with its terms, except (A) as such enforcement is limited by bankruptcy, insolvency or other similar laws affecting the enforcement of creditors’ rights generally and (B) for limitations imposedby general principles of equity. 

**7.2         Effect of Agreement.**This Agreement shall become effective as of the Effective Time. Except as modified by the terms of this Agreement, the terms and provisions of the Investor Rights Agreement shall remain in full force and effect. Other than as stated in thisAgreement, this Agreement shall not operate as a waiver of any condition or obligation imposed on the parties under the Investor Rights Agreement. In the event of any conflict, inconsistency, or incongruity between any provision of this Agreementand any provision of the Investor Rights Agreement, the provisions of this Agreement shall govern and control. This Agreement shall not be changed or modified orally, but only by an instrument in writing signed by the parties hereto. 

**7.3         Governing Law.** This Agreement shall be governed by, andconstrued in accordance with, the laws of the State of California excluding those laws that direct the application of the laws of another jurisdiction. 

**7.4         Successors and Assigns.** The provisions hereof shall inure to the benefit of, and be binding upon, the successors, assigns, heirs, executors andadministrators of the parties hereto and each Holder and Investor, and shall be enforceable by New Jazz or any Holder or Investor. 

**7.5         Counterparts**. This Agreement may be executed in several counterparts, each of which shall constitute an original and all of which, when takentogether, shall constitute one instrument. 

**[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]**

 
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**IN WITNESS WHEREOF,** theundersigned have executed this **ASSIGNMENT, ASSUMPTIONAND AMENDMENT AGREEMENT**on this 18th day of January, 2012. 

**JPI:**

**JAZZ PHARMACEUTICALS, INC.**

Signature:  /s/ Bruce C.Cozadd                            

Print Name:  Bruce C.Cozadd                                

Title:  Chairman & Chief Executive Officer        

 
[SIGNATUREPAGE TO ASSIGNMENT, ASSUMPTION AND AMENDMENT AGREEMENT] 

**IN WITNESS WHEREOF,** theundersigned have executed this **ASSIGNMENT, ASSUMPTIONAND AMENDMENT AGREEMENT**on this 18th day of January, 2012. 

 

**NEW JAZZ:**

 

**JAZZ PHARMACEUTICALS PUBLIC LIMITEDCOMPAN****Y**

Signature:  /s/ DavidBrabazon                            

Print Name:  DavidBrabazon                                

Title:  Senior Vice President,Finance                  

 
[SIGNATUREPAGE TO ASSIGNMENT, ASSUMPTION AND AMENDMENT AGREEMENT] 

**IN WITNESS WHEREOF,** theundersigned have executed this **ASSIGNMENT, ASSUMPTIONAND AMENDMENT AGREEMENT**on this 18th day of January, 2012. 

**HOLDERS:**

 

**KKR JP LLC**

Signature:  /s/ JamesMomtazee                            

Print Name:  JamesMomtazee                                

Title:  VicePresident                                                

 

******KKR JP III LLC**
Signature:  /s/James Momtazee                            Print Name:  JamesMomtazee                                Title:  Vice President                                                
 
[SIGNATUREPAGE TO ASSIGNMENT, ASSUMPTION AND AMENDMENT AGREEMENT] 

**IN WITNESS WHEREOF,** theundersigned have executed this **ASSIGNMENT, ASSUMPTIONAND AMENDMENT AGREEMENT**on this 18th day of January, 2012. 

**HOLDERS:**

 

**VERSANT VENTURE CAPITAL II, L.P.**

By:

 

 
 
Versant Ventures II, L.L.C.,

its General Partner

Signature:  /s/ Samuel D.Colella                                
Print Name:  Samuel D. Colella                                    Title:       ManagingDirector                                        
 

**VERSANT SIDE FUND II, L.P.**

By:

 

 
 
Versant Ventures II, L.L.C.,

its General Partner

Signature:  /s/ Samuel D.Colella                                
Print Name:  Samuel D. Colella                                    Title:       ManagingDirector                                        
 

**VERSANT AFFILIATES FUND II-A, L.P.**

By:

 

 
 
Versant Ventures II, L.L.C.,

its General Partner

Signature:  /s/ Samuel D.Colella                                
Print Name:  Samuel D. Colella                                    Title:       ManagingDirector                                        
 
[SIGNATUREPAGE TO ASSIGNMENT, ASSUMPTION AND AMENDMENT AGREEMENT] 

**IN WITNESS WHEREOF,** theundersigned have executed this **ASSIGNMENT, ASSUMPTIONAND AMENDMENT AGREEMENT**on this 13th day of January, 2012. 

**HOLDERS:**

 

**THOMA CRESSEY FUND VII, L.P.**

By:
 
TC Partners VII, L.P.

Its:
 
General Partner

By:
 
Thoma Cressey Bravo Inc.

Its:
 
General Partner

 

Signature:  /s/ Bryan Cressey                                
Print Name:  Bryan Cressey                                     Title:       Partner                                                         
 

**THOMA CRESSEY FRIENDS FUND VII, L.P.**

By:
 
TC Partners VII, L.P.

Its:
 
General Partner

By:
 
Thoma Cressey Bravo Inc.

Its:
 
General Partner

 

Signature:  /s/ Bryan Cressey                                
Print Name:  Bryan Cressey                                     Title:       Partner                                                         
 
[SIGNATUREPAGE TO ASSIGNMENT, ASSUMPTION AND AMENDMENT AGREEMENT] 

**EXHIBIT A**

**AZUR RIGHTS AGREEMENT**

 
**EXHIBIT A**