56104 Federal Register / Vol. 75, No. 178 / Wednesday, September 15, 2010 / Notices 

consisting of seven members who are 

appointed by the EPA Administrator 

from nominees provided by the National 

Institutes of Health and the National 

Science Foundation. FIFRA, as 

amended by FQPA, established a 

Science Review Board consisting of at 

least 60 scientists who are available to 

the SAP on an ad hoc basis to assist in 

reviews conducted by the SAP. As a 

peer review mechanism, FIFRA SAP 

provides comments, evaluations and 

recommendations to improve the 

effectiveness and quality of analyses 

made by Agency scientists. Members of 

FIFRA SAP are scientists who have 

sufficient professional qualifications, 

including training and experience, to 

provide expert advice and 

recommendation to the Agency. 

B. Public Meeting 

Chlorpyrifos (0,0-diethyl-0-3,5,6- 

trichloro-2-pyridyl phosphorothioate) is 

a broad-spectrum, chlorinated 

organophosphate (OP) insecticide. In 

2000, nearly all residential uses were 

voluntarily canceled by Dow 

AgroSciences, but agricultural uses 

remain. The 2000 human health risk 

assessment was largely based on adult 

laboratory animal data (rat or dog) for 

cholinesterase inhibition and the 

application of default uncertainty 

factors to address inter- and intraspecies differences including 

susceptible populations. Currently, the 

Agency is developing a new human 

health risk assessment expected to be 

released in 2010. In 2008, the FIFRA 

SAP reviewed a draft science issue 

paper on the human health effects of 

chlorpyrifos. Since that time, Dow 

AgroSciences has undergone a research 

effort to improve the existing PBPK/PD 

model developed by Dr. Charles 

Timchalk and co-workers at Pacific 

Northwest National Laboratory. Dow 

AgroSciences has also developed a 

proposed approach for linking this 

PBPK/PD model to the CARES, see 

http://www.ilsi.org/ 

ResearchFoundation/Pages/ 

CARES.aspx, a publically available 

probabilistic exposure model. The 

purpose of the October 2010 SAP 

meeting will be to review the PBPK/PD 

model and to evaluate the proposed 

approach for linking this model to 

CARES. The linking of the chlorpyrifos 

PBPK/PD model to CARES may provide 

opportunities to integrate distributions 

of exposure to chlorpyrifos and its 

metabolites with cholinesterase 

inhibition levels across the U.S. 

population. In addition, this approach 

may allow estimation of data-derived 

uncertainty factors that consider use of 

toxicokinetic and toxicodynamic data to 

inform quantitative extrapolations for 

interspecies differences and human 

variability in dose response assessment. 

The topics to be covered in the October 

2010 SAP are consistent with EPA’s 

Office of Pesticide Programs continuing 

efforts to improve the scientific basis for 

risk assessment by broadening the 

application of probabilistic exposure 

techniques and PBPK models. The 

Agency has a conceptually similar effort 

on-going to link PBPK models for 

pyrethroids to the Stochastic Human 

Exposure and Dose Simulation model 

for multimedia and multipathway 

chemicals (SHEDS-Multimedia), a 

probabilistic exposure model developed 

by EPA’s Office of Research and 

Development, that was reviewed by the 

SAP in July 2010. The current effort by 

Dow AgroSciences is a research effort 

which may, if sufficiently robust, inform 

future risk assessments. The October 

meeting is a key milestone in this effort. 

The Agency will solicit feedback from 

the Panel on technical issues related to 

the PBPK/PD model, the proposed 

approach for linking the PBPK/PD 

model with CARES, and the use of such 

linked models in risk assessment. 

C. FIFRA SAP Documents and Meeting 

Minutes 

EPA’s background paper, related 

supporting materials, charge/questions 

to FIFRA SAP, FIFRA SAP composition 

(i.e., members and ad hoc members for 

this meeting), and the meeting agenda 

will be available by mid-October 2010. 

In addition, the Agency may provide 

additional background documents as the 

materials become available. You may 

obtain electronic copies of these 

documents, and certain other related 

documents that might be available 

electronically, at http:// 

www.regulations.gov and the FIFRA 

SAP homepage at http://www.epa.gov/ 

scipoly/sap. 

FIFRA SAP will prepare meeting 

minutes summarizing its 

recommendations to the Agency 

approximately 90 days after the 

meeting. The meeting minutes will be 

posted on the FIFRA SAP website or 

may be obtained from the OPP 

Regulatory Public Docket at http:// 

www.regulations.gov. 

List of Subjects 

Environmental protection, Pesticides 

and pests. 

Dated: September 2, 2010. 

Steven M. Knott, 

Acting Director, Office of Science 

Coordination and Policy. 

[FR Doc. 2010–22974 Filed 9–14–10; 8:45 am] 

BILLING CODE 6560–50–S 

ENVIRONMENTAL PROTECTION 

AGENCY 

[FRL–9201–8] 

Science Advisory Board Staff Office; 

Notification of Public Teleconferences 

of the Mountaintop Mining Panel 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: The EPA Science Advisory 

Board (SAB) Staff Office announces two 

public teleconferences of the SAB 

Mountaintop Mining Panel to discuss 

the Panel’s draft reports. 

DATES: A public teleconference will be 

held on Wednesday, October 20, 2010 

from 1 p.m. to 5 p.m. (Eastern Time). 

Should the Panel need additional time, 

a second public teleconference will be 

held on Tuesday, October 26, 2010 from 

1 p.m. to 4 p.m. (Eastern Time). 

ADDRESSES: The public teleconference 

will be conducted by telephone only. 

FOR FURTHER INFORMATION CONTACT: Any 

member of the public wishing to obtain 

general information concerning the 

public teleconference may contact Mr. 

Edward Hanlon, Designated Federal 

Officer (DFO), via telephone at (202) 

564–2134 or e-mail at 

hanlon.edward@epa.gov. General 

information concerning the EPA Science 

Advisory Board can be found on the 

SAB Web site at http://www.epa.gov/ 

sab. 

SUPPLEMENTARY INFORMATION: Pursuant 

to the Federal Advisory Committee Act 

(FACA), 5 U.S.C., App. 2, notice is 

hereby given that the SAB Mountaintop 

Mining Panel will hold a public 

teleconference to discuss its draft 

reports. The SAB was established 

pursuant to 42 U.S.C. 4365 to provide 

independent scientific and technical 

advice to the Administrator on the 

technical basis for Agency positions and 

regulations. The SAB is a Federal 

Advisory Committee under FACA. The 

SAB will comply with the provisions of 

FACA and all appropriate SAB Staff 

Office procedural policies. 

The Panel met on July 20–22, 2010 to 

review EPA’s The Effects of 

Mountaintop Mines and Valley Fills on 

Aquatic Ecosystems of the Central 

Appalachian Coalfields and Field-Based 

Aquatic Life Benchmark for 

Conductivity in Central Appalachian 

Streams draft reports [Federal Register 

Notice dated May 25, 2010 (75 FR 

29339–29340)]. Materials from the July 

2010 meeting are posted on the SAB 

Web site at http://yosemite.epa.gov/sab/ 

sabproduct.nsf/

a84bfee16cc358ad85256ccd006b0b4b/ 


srobinson on DSKHWCL6B1PROD with NOTICES
Federal Register / Vol. 75, No. 178 / Wednesday, September 15, 2010 / Notices 56105 

4bb87d5b9c6dea458525770400481586!

OpenDocument&Date=2010-07-21. The 

purpose of the October 20, 2010 

teleconference call and the October 26, 

2010 teleconference call if it occurs is to 

discuss the Panel’s draft peer review 

reports of the two EPA documents. 

Availability of Meeting Materials: 

Agendas and materials in support of 

these meetings will be placed on the 

EPA Web site at http://www.epa.gov/sab 

in advance of each meeting. For 

technical questions and information 

concerning EPA’s draft documents, 

please contact Dr. Michael Slimak, EPA 

Office of Research and Development 

(ORD), at (703) 347–8524 or by e-mail at 

slimak.michael@epa.gov. 

Procedures for Providing Public Input: 

Interested members of the public may 

submit relevant written or oral 

information for the Mountaintop Mining 

Panel to consider on the topics of this 

advisory activity. Oral Statements: In 

general, individuals or groups 

requesting an oral presentation at a 

teleconference meeting will be limited 

to three minutes per speaker, with no 

more than a total of one hour for all 

speakers. Interested parties should 

contact Mr. Hanlon at the contact 

information provided above by October 

13, 2010, to be placed on the public 

speaker list for the October 20, 2010 

teleconference call. Written Statements: 

Written statements should be received 

in the SAB Staff Office by October 13, 

2010 for the October 20, 2010 

teleconference call, so that the 

information can be made available to 

the Mountaintop Mining Panel for their 

consideration prior to the teleconference 

call. Written statements should be 

supplied to Mr. Hanlon in the following 

formats: One hard copy with original 

signature and one electronic copy via email (acceptable file format: Adobe 

Acrobat PDF, MS Word, WordPerfect, 

MS PowerPoint, or Rich Text files). 

Submitters are asked to provide 

electronic versions of each document 

submitted with and without signatures, 

because the SAB Staff Office does not 

publish documents with signatures on 

its Web sites. 

Accessibility: For information on 

access or services for individuals with 

disabilities, please contact Mr. Hanlon 

at (202) 564–2134 or e-mail at 

hanlon.edward@epa.gov, preferably at 

least ten (10) days prior to the meeting, 

to give EPA as much time as possible to 

process your request. 

Dated: September 8, 2010. 

Anthony F. Maciorowski, 

Deputy Director, EPA Science Advisory Board 

Staff Office. 

[FR Doc. 2010–22979 Filed 9–14–10; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPP–2010–0008; FRL–8843–5] 

Pesticide Products; Registration 

Applications 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: This notice announces receipt 

of applications to register new uses for 

pesticide products containing currently 

registered active ingredients, pursuant 

to the provisions of section 3(c) of the 

Federal Insecticide, Fungicide, and 

Rodenticide Act (FIFRA), as amended. 

EPA is publishing this notice of such 

applications, pursuant to section 3(c)(4) 

of FIFRA. 

DATES: Comments must be received on 

or before October 15, 2010. 

ADDRESSES: Submit your comments, 

identified by docket identification (ID) 

number specified within Unit II. of the 

SUPPLEMENTARY INFORMATION, by one of 

the following methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the on-line 

instructions for submitting comments. 

• Mail: Office of Pesticide Programs 

(OPP) Regulatory Public Docket (7502P), 

Environmental Protection Agency, 1200 

Pennsylvania Ave., NW., Washington, 

DC 20460–0001. 

• Delivery: OPP Regulatory Public 

Docket (7502P), Environmental 

Protection Agency, Rm. S–4400, One 

Potomac Yard (South Bldg.), 2777 S. 

Crystal Dr., Arlington, VA. Deliveries 

are only accepted during the Docket 

Facility’s normal hours of operation 

(8:30 a.m. to 4 p.m., Monday through 

Friday, excluding legal holidays). 

Special arrangements should be made 

for deliveries of boxed information. The 

Docket Facility telephone number is 

(703) 305–5805. 

Instructions: Direct your comments to 

docket ID number specified for the 

pesticide of interest as shown in the 

registration application summaries. 

EPA’s policy is that all comments 

received will be included in the docket 

without change and may be made 

available on-line at http:// 

www.regulations.gov, including any 

personal information provided, unless 

the comment includes information 

claimed to be Confidential Business 

Information (CBI) or other information 

whose disclosure is restricted by statute. 

Do not submit information that you 

consider to be CBI or otherwise 

protected through regulations.gov or email. The regulations.gov website is an 

‘‘anonymous access’’ system, which 

means EPA will not know your identity 

or contact information unless you 

provide it in the body of your comment. 

If you send an e-mail comment directly 

to EPA without going through 

regulations.gov, your e-mail address 

will be automatically captured and 

included as part of the comment that is 

placed in the docket and made available 

on the Internet. If you submit an 

electronic comment, EPA recommends 

that you include your name and other 

contact information in the body of your 

comment and with any disk or CD-ROM 

you submit. If EPA cannot read your 

comment due to technical difficulties 

and cannot contact you for clarification, 

EPA may not be able to consider your 

comment. Electronic files should avoid 

the use of special characters, any form 

of encryption, and be free of any defects 

or viruses. 

Docket: All documents in the docket 

are listed in the docket index available 

at http://www.regulations.gov. Although 

listed in the index, some information is 

not publicly available, e.g., CBI or other 

information whose disclosure is 

restricted by statute. Certain other 

material, such as copyrighted material, 

is not placed on the Internet and will be 

publicly available only in hard copy 

form. Publicly available docket 

materials are available either in the 

electronic docket at http:// 

www.regulations.gov, or, if only 

available in hard copy, at the OPP 

Regulatory Public Docket in Rm. S– 

4400, One Potomac Yard (South Bldg.), 

2777 S. Crystal Dr., Arlington, VA. The 

hours of operation of this Docket 

Facility are from 8:30 a.m. to 4 p.m., 

Monday through Friday, excluding legal 

holidays. The Docket Facility telephone 

number is (703) 305–5805. 

FOR FURTHER INFORMATION CONTACT: A 

contact person is listed at the end of 

each registration application summary 

and may be contacted by telephone or 

e-mail. The mailing address for each 

contact person listed is: Registration 

Division (7505P), Office of Pesticide 

Programs, Environmental Protection 

Agency, 1200 Pennsylvania Ave., NW., 

Washington, DC 20460–0001. 

SUPPLEMENTARY INFORMATION: 


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