##### Table of Contents





UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-Q

QUARTERLY REPORT

pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2008

001-33635

(Commission file number)

CARDIUM THERAPEUTICS, INC.

(Exact name of registrant as specified in its charter)



|                                                            |  |                                  
|----------------------------------------------------------- |  | ---------------------------------
|Delaware                                                    |  | 27-0075787                       
|(State of incorporation)                                    |  | (IRS Employer Identification No.)
|                                                            | 
|12255 El Camino Real, Suite 250 San Diego, California 92130 |  | (858) 436-1000                   
|(Address of principal executive offices)                    |  | (Registrants telephone number)  

Indicate by check mark whether Cardium Therapeutics, Inc. (Cardium) (1) has filed all reports required to be
filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that Cardium was required to file such reports), and (2) has been subject to such filing requirements for the
past 90 days.

x  Yes     ̈  No

Indicate by check mark whether Cardium is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company (as defined in Rule
12b-2 of the Exchange Act).

Large accelerated filer   ̈            Accelerated filer  x            Non-accelerated filer   ̈            Smaller reporting company   ̈

Indicate by check mark whether Cardium is a shell company (as defined in Rule 12b-2 of the Exchange Act.):

 ̈  Yes    x  No

As of November 7, 2008,
46,930,439 shares of Cardiums common stock were outstanding.









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##### Table of Contents

TABLE OF CONTENTS



|           |  |                                                                                       |  |     
|---------- |  | ------------------------------------------------------------------------------------- |  | ----
|           |  |                                                                                       |  | Page
|PART I     |  | FINANCIAL INFORMATION                                                                 |  | 1   
|           |  |                                                                                      
|Item 1.    |  | Financial Statements (Unaudited)                                                      |  | 1   
|           |  |                                                                                      
|           |  | Condensed Consolidated Balance Sheets                                                 |  | 1   
|           |  |                                                                                      
|           |  | Condensed Consolidated Statements of Operations                                       |  | 2   
|           |  |                                                                                      
|           |  | Condensed Consolidated Statements of Cash Flows                                       |  | 3   
|           |  |                                                                                      
|           |  | Notes to Condensed Consolidated Financial Statements                                  |  | 4   
|           |  |                                                                                      
|Item 2.    |  | Managements Discussion and Analysis of Financial Condition and Results of Operations |  | 10  
|           |  |                                                                                      
|Item 3.    |  | Quantitative and Qualitative Disclosures About Market Risk                            |  | 15  
|           |  |                                                                                      
|Item 4.    |  | Controls and Procedures                                                               |  | 15  
|           |  |                                                                                      
|PART II    |  | OTHER INFORMATION                                                                     |  | 16  
|           |  |                                                                                      
|Item 1.    |  | Legal Proceedings                                                                     |  | 16  
|           |  |                                                                                      
|Item 1A.   |  | Risk Factors                                                                          |  | 16  
|           |  |                                                                                      
|Item 2.    |  | Unregistered Sales of Equity Securities and Use of Proceeds                           |  | 16  
|           |  |                                                                                      
|Item 3.    |  | Defaults Upon Senior Securities                                                       |  | 16  
|           |  |                                                                                      
|Item 4.    |  | Submission of Matters to a Vote of Security Holders                                   |  | 16  
|           |  |                                                                                      
|Item 5.    |  | Other Information                                                                     |  | 16  
|           |  |                                                                                      
|Item 6.    |  | Exhibits                                                                              |  | 17  
|           | 
|SIGNATURES |  | 21                                                                                   



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##### Table of Contents

PART I  FINANCIAL INFORMATION



|ITEM 1. | FINANCIAL STATEMENTS
|------- | --------------------

CARDIUM THERAPEUTICS, INC.

(a development stage company)

Condensed Consolidated Balance Sheets



|                                                                                                                                                            |  |                   |             |   |                  |   |             |  
|----------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ----------------- | ----------- | - | ---------------- | - | ----------- | -
|                                                                                                                                                            |  | September 30,2008 |             |   | December 31,2007 |  
|                                                                                                                                                            |  | (Unaudited)       |             |   | (Audited)        |  
|Assets                                                                                                                                                      |  |                   |             |   |                  |   |             |  
|Current assets:                                                                                                                                             |  |                   |             |   |                  |   |             |  
|Cash and cash equivalents                                                                                                                                   |  | $                 | 126,575     |   |                  | $ | 7,722,816   |  
|Accounts receivable, net of allowance for doubtful accounts of $8,750 at September 30, 2008 and $5,936 at December 31,
2007                                 |  |                   | 119,849     |   |                  |   | 565,613     |  
|Inventories, net                                                                                                                                            |  |                   | 1,818,021   |   |                  |   | 1,037,164   |  
|Prepaid expenses and other current assets                                                                                                                   |  |                   | 414,933     |   |                  |   | 522,067     |  
|                                                                                                                                                            |  |                   |             |   |                  |   |             |  
|Total current assets                                                                                                                                        |  |                   | 2,479,378   |   |                  |   | 9,847,660   |  
|Restricted cash                                                                                                                                             |  |                   | 500,000     |   |                  |   | 500,000     |  
|Property and equipment, net                                                                                                                                 |  |                   | 1,798,529   |   |                  |   | 1,650,632   |  
|Patented technology, net                                                                                                                                    |  |                   | 4,022,780   |   |                  |   | 4,582,009   |  
|Intangibles, net                                                                                                                                            |  |                   | 151,308     |   |                  |   | 184,321     |  
|Deferred financing costs, net                                                                                                                               |  |                   |            |   |                  |   | 66,306      |  
|Deposits                                                                                                                                                    |  |                   | 100,041     |   |                  |   | 94,761      |  
|                                                                                                                                                            |  |                   |             |   |                  |   |             |  
|Total assets                                                                                                                                                |  | $                 | 9,052,036   |   |                  | $ | 16,925,689  |  
|                                                                                                                                                            |  |                   |             |   |                  |   |             |  
|Liabilities and Stockholders Equity                                                                                                                        |  |                   |             |   |                  |   |             |  
|Current liabilities:                                                                                                                                        |  |                   |             |   |                  |   |             |  
|Accounts payable                                                                                                                                            |  | $                 | 4,658,266   |   |                  | $ | 1,461,458   |  
|Accrued liabilities                                                                                                                                         |  |                   | 2,724,689   |   |                  |   | 2,311,849   |  
|Current portion of long-term debt, net of debt discount of $49,214 at December 31, 2007                                                                     |  |                   |            |   |                  |   | 1,482,085   |  
|                                                                                                                                                            |  |                   |             |   |                  |   |             |  
|Total current liabilities                                                                                                                                   |  |                   | 7,382,955   |   |                  |   | 5,255,392   |  
|                                                                                                                                                            |  |                   |             |   |                  |   |             |  
|Deferred rent                                                                                                                                               |  |                   | 192,840     |   |                  |   |            |  
|Long-term debt, less current portion, net of debt discount of $90,224 at December 31, 2007                                                                  |  |                   |            |   |                  |   | 3,241,992   |  
|                                                                                                                                                            |  |                   |             |   |                  |   |             |  
|Total liabilities                                                                                                                                           |  |                   | 7,575,795   |   |                  |   | 8,497,384   |  
|                                                                                                                                                            |  |                   |             |   |                  |   |             |  
|Commitments and contingencies                                                                                                                               |  |                   |             |   |                  |   |             |  
|Stockholders equity:                                                                                                                                       |  |                   |             |   |                  |   |             |  
|Common stock, $0.0001 par value; 200,000,000 shares authorized; issued and outstanding at September 30, 2008 46,930,439 and 40,955,291 at
December 31, 2007 |  |                   | 4,693       |   |                  |   | 4,095       |  
|Additional paid-in capital                                                                                                                                  |  |                   | 70,352,243  |   |                  |   | 57,784,800  |  
|Deficit accumulated during development stage                                                                                                                |  |                   | (68,880,695 | ) |                  |   | (49,360,590 | )
|                                                                                                                                                            |  |                   |             |   |                  |   |             |  
|Total stockholders equity                                                                                                                                  |  |                   | 1,476,241   |   |                  |   | 8,428,305   |  
|                                                                                                                                                            |  |                   |             |   |                  |   |             |  
|Total liabilities and stockholders equity                                                                                                                  |  | $                 | 9,052,036   |   |                  | $ | 16,925,689  |  
|                                                                                                                                                            |  |                   |             |   |                  |   |             |  

See accompanying notes, which are an integral part of these condensed consolidated financial
statements.



1



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##### Table of Contents

CARDIUM THERAPEUTICS, INC.

(a development stage company)

Condensed
Consolidated Statements of Operations

(Unaudited)



|                                                               |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|-------------------------------------------------------------- |  | ------------------------------- | ---------- | - | ------------------------------ | - | ---------- | ----------------------------------------------------------- |  | - | ----------- | - |  | - | ----------- | - |  | - | ----------- | -
|                                                               |  | Three Months EndedSeptember 30, |            |   | Nine Months EndedSeptember 30, |   |            | Period fromDecember 22, 2003(Inception) toSeptember 30,2008 | 
|                                                               |  | 2008                            |            |   | 2007                           |   |            | 2008                                                        |  |   | 2007        |   | 
|Revenues                                                       |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|Product sales                                                  |  | $                               | 585,421    |   |                                | $ | 306,992    |                                                             |  | $ | 1,483,631   |   |  | $ | 771,762     |   |  | $ | 3,309,464   |  
|Grant revenues                                                 |  |                                 |           |   |                                |   | 57,338     |                                                             |  |   | 374,633     |   |  |   | 131,371     |   |  |   | 891,456     |  
|                                                               |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|Total revenues                                                 |  |                                 | 585,421    |   |                                |   | 364,330    |                                                             |  |   | 1,858,264   |   |  |   | 903,133     |   |  |   | 4,200,920   |  
|Cost of goods sold                                             |  |                                 | 514,243    |   |                                |   | 318,934    |                                                             |  |   | 1,199,193   |   |  |   | 823,676     |   |  |   | 3,501,722   |  
|                                                               |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|Gross profit                                                   |  |                                 | 71,178     |   |                                |   | 45,396     |                                                             |  |   | 659,071     |   |  |   | 79,457      |   |  |   | 699,198     |  
|                                                               |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|Operating expenses                                             |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|Research and development                                       |  |                                 | 2,947,997  |   |                                |   | 3,243,008  |                                                             |  |   | 10,289,883  |   |  |   | 9,901,087   |   |  |   | 35,792,056  |  
|Selling, general and administrative                            |  |                                 | 2,886,089  |   |                                |   | 2,838,949  |                                                             |  |   | 8,968,214   |   |  |   | 8,356,498   |   |  |   | 32,748,550  |  
|Amortization - intangibles                                     |  |                                 | 197,414    |   |                                |   | 178,156    |                                                             |  |   | 592,242     |   |  |   | 592,242     |   |  |   | 2,055,128   |  
|                                                               |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|Total operating expenses                                       |  |                                 | 6,031,500  |   |                                |   | 6,260,113  |                                                             |  |   | 19,850,339  |   |  |   | 18,849,827  |   |  |   | 70,595,734  |  
|                                                               |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|Loss from operations                                           |  |                                 | (5,960,322 | ) |                                |   | (6,214,717 | )                                                           |  |   | (19,191,268 | ) |  |   | (18,770,370 | ) |  |   | (69,896,536 | )
|                                                               |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|Interest income                                                |  |                                 | 8,028      |   |                                |   | 146,748    |                                                             |  |   | 95,664      |   |  |   | 461,371     |   |  |   | 1,498,581   |  
|Interest expense                                               |  |                                 | (199,221   | ) |                                |   |           |                                                             |  |   | (424,501    | ) |  |   |            |   |  |   | (482,740    | )
|                                                               |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|Net loss                                                       |  | $                               | (6,151,515 | ) |                                | $ | (6,067,969 | )                                                           |  | $ | (19,520,105 | ) |  | $ | (18,308,999 | ) |  | $ | (68,880,695 | )
|                                                               |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|Net loss per common share basic and diluted                   |  | $                               | (0.13      | ) |                                | $ | (0.15      | )                                                           |  | $ | (0.44       | ) |  | $ | (0.47       | ) |  |   |             |  
|                                                               |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  
|Weighted average common shares outstanding  basic and diluted |  |                                 | 46,603,700 |   |                                |   | 40,928,219 |                                                             |  |   | 44,322,663  |   |  |   | 38,759,118  |   |  |   |             |  
|                                                               |  |                                 |            |   |                                |   |            |                                                             |  |   |             |   |  |   |             |   |  |   |             |  

See accompanying notes, which are an integral part of these condensed consolidated financial
statements.



2



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##### Table of Contents

CARDIUM THERAPEUTICS, INC.

(a development stage company)

Condensed
Consolidated Statements of Cash Flows

(Unaudited)



|                                                                                    |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|----------------------------------------------------------------------------------- |  | -------------------------------------- | ----------- | - | ----------------------------------------------------------- | - | ----------- | - |  | - | ----------- | -
|                                                                                    |  | For the Nine Months EndedSeptember 30, |             |   | Period
fromDecember 22, 2003(Inception)To September 30,2008 |  
|                                                                                    |  | 2008                                   |             |   | 2007                                                        |   |            
|Cash Flows From Operating Activities                                                |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Net loss                                                                            |  | $                                      | (19,520,105 | ) |                                                             | $ | (18,308,999 | ) |  | $ | (68,880,695 | )
|Adjustments to reconcile net loss to net cash used in operating activities:         |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Depreciation                                                                        |  |                                        | 475,627     |   |                                                             |   | 241,430     |   |  |   | 1,103,195   |  
|Amortizationintangibles                                                            |  |                                        | 592,242     |   |                                                             |   | 592,242     |   |  |   | 2,055,128   |  
|Amortizationdebt discount                                                          |  |                                        | 139,439     |   |                                                             |   |            |   |  |   | 147,641     |  
|Amortizationdeferred financing costs                                               |  |                                        | 102,472     |   |                                                             |   |            |   |  |   | 108,500     |  
|Provision for obsolete inventory                                                    |  |                                        | 12,224      |   |                                                             |   |            |   |  |   | 663,105     |  
|Provision for doubtful accounts                                                     |  |                                        | 2,814       |   |                                                             |   |            |   |  |   | 8,750       |  
|Common stock issued for services and reimbursement of expenses                      |  |                                        |            |   |                                                             |   |            |   |  |   | 41,500      |  
|Stock based compensation expense                                                    |  |                                        | 1,617,633   |   |                                                             |   | 1,736,828   |   |  |   | 5,581,879   |  
|In-process purchased technology                                                     |  |                                        | 1,000,000   |   |                                                             |   |            |   |  |   | 2,027,529   |  
|Changes in operating assets and liabilities, excluding effects of acquisition:      |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Accounts receivable                                                                 |  |                                        | 442,950     |   |                                                             |   | (2,263      | ) |  |   | 47,995      |  
|Inventories                                                                         |  |                                        | (793,081    | ) |                                                             |   | (306,596    | ) |  |   | (2,384,462  | )
|Prepaid expenses and other current assets                                           |  |                                        | 70,967      |   |                                                             |   | 336,305     |   |  |   | (396,386    | )
|Deposits                                                                            |  |                                        | (5,280      | ) |                                                             |   | (133,775    | ) |  |   | (73,380     | )
|Deferred rent                                                                       |  |                                        | 192,840     |   |                                                             |   |            |   |  |   | 192,840     |  
|Accounts payable                                                                    |  |                                        | 3,196,808   |   |                                                             |   | 1,065,523   |   |  |   | 4,609,836   |  
|Accrued liabilities                                                                 |  |                                        | 412,840     |   |                                                             |   | (940,386    | ) |  |   | 1,821,038   |  
|                                                                                    |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Net cash used in operating activities                                               |  |                                        | (12,059,610 | ) |                                                             |   | (15,719,691 | ) |  |   | (53,325,987 | )
|                                                                                    |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Cash Flows From Investing Activities                                                |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|In-process technology purchased from Tissue Repair Company                          |  |                                        | (1,000,000  | ) |                                                             |   |            |   |  |   | (2,000,000  | )
|Purchases of property and equipment                                                 |  |                                        | (623,524    | ) |                                                             |   | (1,077,113  | ) |  |   | (2,701,655  | )
|                                                                                    |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Net cash used in investing activities                                               |  |                                        | (1,623,524  | ) |                                                             |   | (1,077,113  | ) |  |   | (4,701,655  | )
|                                                                                    |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Cash Flows From Financing Activities                                                |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Proceeds from officers loans                                                        |  |                                        |            |   |                                                             |   |            |   |  |   | 62,882      |  
|Cash acquired in Aries merger and InnerCool acquisition                             |  |                                        |            |   |                                                             |   |            |   |  |   | 1,551,800   |  
|Restricted cash                                                                     |  |                                        |            |   |                                                             |   |            |   |  |   | (500,000    | )
|Proceeds from the exercise of warrants, net                                         |  |                                        | 22,501      |   |                                                             |   | 26,275      |   |  |   | 547,375     |  
|Proceeds from debt financing agreement, net of deferred financing costs of $108,500 |  |                                        |            |   |                                                             |   |            |   |  |   | 4,891,500   |  
|Repayment of debt                                                                   |  |                                        | (4,863,515  | ) |                                                             |   |            |   |  |   | (5,000,000  | )
|Proceeds from the sale of common stock, net                                         |  |                                        | 10,927,907  |   |                                                             |   | 20,093,364  |   |  |   | 56,600,660  |  
|                                                                                    |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Net cash provided by financing activities                                           |  |                                        | 6,086,893   |   |                                                             |   | 20,119,639  |   |  |   | 58,154,217  |  
|                                                                                    |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Net (decrease) increase in cash                                                     |  |                                        | (7,596,241  | ) |                                                             |   | 3,322,835   |   |  |   | 126,575     |  
|Cash and cash equivalents at beginning of period                                    |  |                                        | 7,722,816   |   |                                                             |   | 5,931,123   |   |  |   |            |  
|                                                                                    |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Cash and cash equivalents at end of period                                          |  | $                                      | 126,575     |   |                                                             | $ | 9,253,958   |   |  | $ | 126,575     |  
|                                                                                    |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Supplemental Disclosures of Cash Flow Information:                                  |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Cash payments made for interest                                                     |  | $                                      | 219,391     |   |                                                             | $ |            |   |  | $ | 293,122     |  
|Cash payments made for income taxes                                                 |  | $                                      | 2,400       |   |                                                             | $ |            |   |  | $ | 9,600       |  
|Non-Cash Activity:                                                                  |  |                                        |             |   |                                                             |   |             |   |  |   |             |  
|Subscription receivable for common shares                                           |  | $                                      |            |   |                                                             | $ |            |   |  | $ | 17,000      |  
|Common stock issued for repayment of loans                                          |  | $                                      |            |   |                                                             | $ |            |   |  | $ | 62,882      |  
|Net assets acquired for the issuance of common stock (exclusive of cash)            |  | $                                      |            |   |                                                             | $ |            |   |  | $ | 5,824,000   |  
|Warrants issued in connection with debt financing                                   |  | $                                      |            |   |                                                             | $ |            |   |  | $ | 147,640     |  

See accompanying notes, which are an integral part of these condensed consolidated financial
statements.



3



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##### Table of Contents

CARDIUM THERAPEUTICS, INC.

(a development stage company)

NOTES TO
CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(Unaudited)

Note 1. Organization and Liquidity

Organization

Cardium Therapeutics, Inc. (the Company, Cardium, we, our and
us) was organized in Delaware in December 2003. We are a medical technology company primarily focused on the development, manufacture and sale of innovative therapeutic products for cardiovascular, ischemic and related indications. In
October 2005, we acquired a portfolio of biologic growth factors and related delivery techniques from the Schering AG Group, Germany, which we plan to develop as cardiovascular-directed growth factor therapeutics for potential use by interventional
cardiologists as a one-time treatment to promote and stimulate the growth of collateral circulation in the hearts of patients with ischemic conditions such as recurrent angina. In March 2006, we acquired the technologies and products of InnerCool
Therapies, Inc., a medical technology company in the emerging field of therapeutic hypothermia, or patient temperature modulation, whose systems and products are designed to rapidly and controllably cool the body to reduce cell death and damage
following acute ischemic events such as cardiac arrest and stroke, and to potentially lessen or prevent associated injuries such as adverse neurologic outcomes. In August 2006, we acquired rights to assets and technologies of Tissue Repair Company,
a company focused on the development of growth factor therapeutics for the potential treatment of tissue wounds such as chronic diabetic wounds, and whose product candidate, ExcellarateTM, is initially being developed as a single administration for the treatment of non-healing, neuropathic diabetic foot ulcers. InnerCool Therapies and Tissue Repair Company are each
operated as a wholly-owned subsidiary of Cardium.

We are a development stage company. We have yet to generate positive cash flows from operations, and
essentially depend on debt and equity funding to finance our operations. In October 2005, we closed a private placement of 19,325,651 shares of our common stock at a purchase price of $1.50 per share and received net proceeds of $25,542,389. In
connection with the private placement, we completed a reverse merger, whereby Cardium merged with a wholly-owned subsidiary of Aries Ventures Inc. (Aries), a publicly-traded company. As a result of these transactions, the stockholders of
Cardium became the controlling stockholders of Aries. Accordingly, the acquisition of Cardium by Aries was a reverse merger. Aries results of operations are included in Cardiums financial results beginning October 20, 2005.

In January 2006, Aries was merged with and into Cardium, with Cardium as the surviving entity and the successor issuer to Aries. As a result, we are now
in our present form a publicly-traded, Delaware corporation named Cardium Therapeutics, Inc.

Liquidity and Going Concern

Since inception, our operations have consumed substantial amounts of cash and we have had only limited revenues. We anticipate that the negative cash flow from operations
will continue. On January 31, 2008, we completed a registered direct offering of our common stock that resulted in net proceeds to the Company of approximately $5 million. On June 27, 2008, we completed a follow-on registered direct
offering of our common stock that resulted in net proceeds to the Company of approximately $3 million. On July 1, 2008 we paid off the principal balance on our commercial credit facility out of the proceeds from the June 2008 offering. On
July 18, 2008, we completed another registered direct offering for which we received net proceeds of approximately $3 million. (see Note 6 below).

As
of September 30, 2008, we had $126,575 in cash and cash equivalents. On November 10, 2008, we completed a secured debt financing for which we received proceeds of approximately $6 million before placement agent fees and offering expenses
(see Note 8 below). With the completion of our recent debt offering, we believe we will be able to fund required operations for approximately the next three months, not including efforts to accelerate the study of our Generx and Excellarate product
candidates and actively promote the launches of InnerCools CoolBlue and RapidBlue product lines. As a result, we will need to raise additional funds through the sale of equity securities, debt financings, strategic licensing agreements and/or
other corporate transactions. If we do not raise such funds, we will not be able to accelerate our product development activities or maintain operations. Management has been in discussions to raise additional funds but there is no assurance we will
succeed in these efforts. If we are not successful in obtaining additional funds, we will need to scale back our operations and/or sell or partner certain development projects or products, or our operations may not be able to continue as planned or
at all. The previously described conditions raise substantial doubt about the Companys ability to continue as a going concern. The condensed consolidated financial statements do not include any adjustments related to the recoverability of
assets or classifications of liabilities that might be necessary should we be unable to continue as a going concern.



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Note 2. Basis of Presentation and Summary of Certain Significant Accounting Policies

Basis of Presentation

Our principal activities are expected to focus
on the commercialization of our licensed technologies, other technologies and the expansion of our existing products. The accompanying condensed consolidated financial statements have been prepared in accordance with Statement of Financial
Accounting Standard (SFAS) No. 7, Accounting and Reporting by Development Stage Enterprises.

The accompanying interim unaudited condensed
consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America for interim financial information and pursuant to the instructions to Form 10-Q and applicable rules and
regulations. Certain information and footnote disclosures normally included in financial statements prepared in accordance with U.S. generally accepted accounting principles have been condensed or omitted pursuant to such rules and regulations. In
managements opinion, all adjustments necessary for a fair presentation of the consolidated financial position, results of operations and cash flows have been included and are of a normal, recurring nature. The consolidated results of
operations for the three and nine months ended September 30, 2008 are not necessarily indicative of the operating results for the full fiscal year or any future periods.

The accompanying condensed consolidated financial statements and these notes should be read in conjunction with our audited financial statements included in our Annual Report on Form 10-K for the year ended
December 31, 2007 (2007 Annual Report). The accounting policies used to prepare the financial statements included in this report are the same as those described in the notes to the consolidated financial statements in our 2007
Annual Report unless otherwise noted below.

Loss Per Common Share

We compute earnings per share in accordance with SFAS No. 128, Earnings Per Share. SFAS No. 128 requires dual presentation of basic and diluted earnings per share.

Basic loss per common share is computed by dividing net loss by the weighted average number of common shares outstanding during the period. Diluted loss per common share
is computed by dividing net loss by the weighted average number of common shares outstanding, plus the issuance of common shares, if dilutive, resulting from the exercise of outstanding stock options and warrants. These potentially dilutive
securities were not included in the calculation of loss per common share for the three and nine months ended September 30, 2008 and 2007 because, due to the loss we incurred during such periods, their inclusion would have been anti-dilutive.
Accordingly, basic and diluted loss per common share are the same for all periods presented. The common stock issued and outstanding with respect to the stockholders of Aries has been included since October 20, 2005, the effective date of the
reverse merger.

Potentially dilutive securities not included in diluted loss per common share consisted of outstanding stock options and warrants to
acquire 13,942,163 shares as of September 30, 2008 and 11,162,277 shares as of September 30, 2007.

Reclassification

Certain prior year amounts have been reclassified to conform to the current year presentation. The reclassification did not have any effect on reported consolidated net
losses for any periods presented.

Stock-Based Compensation

Effective January 1, 2006, we adopted the fair value recognition provisions of SFAS No. 123 (revised 2004), Share-Based Payment (SFAS 123R), using the modified prospective transition method. Under the transition
method, stock-based compensation expense is recognized (i) for all stock-based compensation awards granted before, but not yet vested as of, January 1, 2006, based on the grant date fair value estimated in accordance with the original
provision of SFAS No. 123, Accounting for Stock-Based Compensation (SFAS 123), and (ii) for all stock-based compensation awards granted after January 1, 2006, based on the grant date fair value estimated in accordance with
the provisions of SFAS 123R.

Stock-based compensation costs are recognized on a straight-line basis over the requisite service period of the award, which
is generally the vesting term of the award. Total stock-based compensation expense included in the condensed consolidated statements of operations was $513,998 for the three months ended September 30, 2008, and $1,617,633 for the nine months
ended September 30, 2008. For the nine months ended September 30, 2008, $739,258 was recorded as a component of research and development expenses and $878,375 was recorded as a component of selling, general and administrative expenses.
Total stock-based compensation expense included in the condensed consolidated statements of operations was $576,027 for the three months ended September 30, 2007, and $1,736,828 for the nine months ended September 30, 2007. For the nine
months ended September 30, 2007, $793,730 was recorded as a component of research and development expenses and $943,098 was recorded as a component of selling, general and administrative expenses. As of September 30, 2008, the Company had
$2,803,414 of unvested stock-based compensation at fair value remaining to be expensed ratably over the period October 2008 through May 2013.



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The fair value of the stock options and similar stock-based compensation granted is estimated on the date of grant using
the Black-Scholes option valuation model. The Black-Scholes option valuation model was developed for use in estimating the fair value of traded options that have no vesting restrictions and are fully transferable. Option valuation models require the
input of highly subjective assumptions, including expected life and stock price volatility. The following weighted-average assumptions were used:



|                        |  |                                         |   |  |      |  
|----------------------- |  | --------------------------------------- | - |  | ---- | -
|                        |  | For the Three MonthsEnded September 30, |  
|                        |  | 2008                                    |   |  | 2007 |  
|Dividend yield          |  | 0                                       | % |  | 0    | %
|Expected life (years)   |  | 5.25                                    |   |  | 5.25 |  
|Risk-free interest rate |  | 3.11                                    | % |  | 4.75 | %
|Volatility              |  | 75                                      | % |  | 76   | %
|                        | 
|                        |  | For the Nine MonthsEnded September 30,  |  
|                        |  | 2008                                    |   |  | 2007 |  
|Dividend yield          |  | 0                                       | % |  | 0    | %
|Expected life (years)   |  | 5.25                                    |   |  | 5.25 |  
|Risk-free interest rate |  | 3.00                                    | % |  | 4.75 | %
|Volatility              |  | 75                                      | % |  | 76   | %

Income Taxes

Effective January 1, 2007, the Company adopted the provisions of Financial Accounting Standards Board (FASB) Interpretation No. 48, Accounting for Uncertainty in Income Taxesan interpretation of FASB Statement
No. 109 (FIN 48). FIN 48 prescribes a recognition threshold and a measurement attribute for the financial statement recognition and measurement of tax positions taken or expected to be taken in a tax return. For those benefits to be
recognized, a tax position must be more-likely-than-not to be sustained upon examination by taxing authorities. Differences between tax positions taken or expected to be taken in a tax return and the benefit recognized and measured pursuant to the
interpretation are referred to as unrecognized benefits. A liability is recognized (or amount of net operating loss carryforward or amount of tax refundable is reduced) for an unrecognized tax benefit because it represents an
enterprises potential future obligation to the taxing authority for a tax position that was not recognized as a result of applying the provisions of FIN 48.

In accordance with FIN 48, interest costs related to unrecognized tax benefits are required to be calculated (if applicable) and would be classified as Interest expense. Penalties, if incurred, would be recognized as a component
of Selling, general and administrative expenses.

The Company files income tax returns in the United States (federal) and in various state and
local jurisdictions. The adoption of the provisions of FIN 48 did not have a material impact on the Companys consolidated financial position and results of operations. As of December 31, 2007 and September 30, 2008, no liability for
unrecognized tax benefits was required to be recorded. The Company does not expect its unrecognized tax benefit position to change during the next 12 months.

The Company recognized a deferred tax asset of approximately $26.8 million as of September 30, 2008, primarily relating to net operating loss carryforwards of approximately $25 million (which excludes net operating losses of $71
million that represent pre-merger losses for which the use is limited in accordance with Section 382 of the Internal Revenue Code of 1986, as amended), available to offset future taxable income through 2028. The net operating losses begin to
expire in 2023 for federal tax purposes and in 2013 for state income tax purposes.

The ultimate realization of deferred tax assets depends on the
generation of future taxable income during the periods in which those net operating losses are available. The Company considers projected future taxable income and tax planning strategies in making its assessment. At present, the Company does not
have a sufficient history of income to conclude that it is more-likely-than-not that the Company will be able to realize all of its tax benefits in the near future and therefore a valuation allowance was established for the full value of the
deferred tax asset.



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##### Table of Contents

A valuation allowance will be maintained until sufficient positive evidence exists to support the reversal of any portion
or all of the valuation. Should the Company become profitable in future periods with supportable trends, the valuation allowance will be reversed accordingly.

Recently Adopted Accounting Pronouncements

In December 2007, the Securities and Exchange Commission issued Staff Accounting Bulletin
No. 110 (SAB 110). SAB 110 amends and replaces Question 6 of Section D.2 of Topic 14, Share-Based Payment of the Staff Accounting Bulletin series. Question 6 of Section D.2 of Topic 14 expresses the views of the staff regarding the use of
the simplified method in developing an estimate of the expected term of plain vanilla share options and allows usage of that method for options granted before December 31, 2007. SAB 110 allows public companies that
do not have sufficient historical experience to provide a reasonable estimate to continue the use of this method for estimating the expected term of plain vanilla share options granted after December 31, 2007. SAB 110 was
effective January 1, 2008. The adoption of this pronouncement did not have a material impact on the Companys condensed consolidated financial statements.

In October 2008, the FASB issued FSP157-3 Determining Fair Value of a Financial Asset in a Market That Is Not Active (FSP 157-3). FSP 157-3 clarified the application of SFAS No. 157 in an active
market. It demonstrated how the fair value of a financial asset is determined when the market for that financial asset is inactive. FSP 157-3 was effective upon issuance, including prior periods for which financial statements had not been issued.
The implementation of this standard did not have a material impact on our condensed consolidated financial statements.

Note 3. Inventories

Inventories consisted of the following:



|                                      |  |                   |           |   |                  |   |           |  
|------------------------------------- |  | ----------------- | --------- | - | ---------------- | - | --------- | -
|                                      |  | September 30,2008 |           |   | December 31,2007 |  
|Raw materials                         |  | $                 | 789,998   |   |                  | $ | 490,688   |  
|Work in process                       |  |                   | 29,380    |   |                  |   | 109,868   |  
|Finished goods                        |  |                   | 1,661,748 |   |                  |   | 1,087,489 |  
|                                      |  |                   |           |   |                  |   |           |  
|                                      |  |                   | 2,481,126 |   |                  |   | 1,688,045 |  
|Less provision for obsolete inventory |  |                   | (663,105  | ) |                  |   | (650,881  | )
|                                      |  |                   |           |   |                  |   |           |  
|Inventories, net                      |  | $                 | 1,818,021 |   |                  | $ | 1,037,164 |  
|                                      |  |                   |           |   |                  |   |           |  

Note 4. Property and Equipment

Property and equipment consisted of the following:



|                                          |  |                   |            |   |                  |   |           |  
|----------------------------------------- |  | ----------------- | ---------- | - | ---------------- | - | --------- | -
|                                          |  | September 30,2008 |            |   | December 31,2007 |  
|Computer and telecommunication equipment  |  | $                 | 640,540    |   |                  | $ | 670,387   |  
|Machinery and equipment                   |  |                   | 852,364    |   |                  |   | 604,299   |  
|Office equipment                          |  |                   | 72,359     |   |                  |   | 27,595    |  
|Instrumentation                           |  |                   | 115,421    |   |                  |   | 115,421   |  
|Office furniture and equipment            |  |                   | 543,041    |   |                  |   | 320,773   |  
|Leasehold improvements                    |  |                   | 677,999    |   |                  |   | 525,225   |  
|                                          |  |                   |            |   |                  |   |           |  
|                                          |  |                   | 2,901,724  |   |                  |   | 2,263,700 |  
|Accumulated depreciation and amortization |  |                   | (1,103,195 | ) |                  |   | (627,568  | )
|                                          |  |                   |            |   |                  |   |           |  
|                                          |  |                   | 1,798,529  |   |                  |   | 1,636,132 |  
|Construction in progress                  |  |                   |           |   |                  |   | 14,500    |  
|                                          |  |                   |            |   |                  |   |           |  
|Property and equipment, net               |  | $                 | 1,798,529  |   |                  | $ | 1,650,632 |  
|                                          |  |                   |            |   |                  |   |           |  



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Depreciation and amortization of property and equipment totaled $168,334 for the three months ended September 30,
2008, and $475,627 for the nine months ended September 30, 2008. Depreciation and amortization of property and equipment totaled $65,930 for the three months ended September 30, 2007, $241,430 for the nine months ended September 30,
2007, and $1,103,195 for the period from December 22, 2003 (date of inception) through September 30, 2008.

Note 5. Accrued Liabilities

Accrued liabilities consisted of the following:



|                                        |  |                   |           |                  |   |          
|--------------------------------------- |  | ----------------- | --------- | ---------------- | - | ---------
|                                        |  | September 30,2008 |           | December 31,2007
|Accrued in-process purchased technology |  | $                 | 500,000   |                  | $ |         
|Accrued expenses -other                 |  |                   | 1,042,279 |                  |   | 590,924  
|Accrued clinical trial costs            |  |                   | 396,641   |                  |   |         
|Accrued payroll and benefits            |  |                   | 785,769   |                  |   | 1,720,925
|                                        |  |                   |           |                  |   |          
|Total                                   |  | $                 | 2,724,689 |                  | $ | 2,311,849
|                                        |  |                   |           |                  |   |          

Note 6. Stockholders Equity

Common Stock

On January 31, 2008, we completed a registered direct offering of our common stock that resulted
in the sale of 2,655,000 shares, in the aggregate, of our common stock at a purchase price of $2.00 per share, and five year warrants to purchase an additional 929,250 shares of our common stock at an exercise price of $2.00. The warrants were fully
exercisable when issued. We received gross proceeds of approximately $5,300,000, before placement agent fees and offering expenses of approximately $400,000. In addition, we issued warrants to purchase 159,300 shares of our common stock to the
placement agent on terms substantially the same as the warrants issued to investors.

On June 27, 2008, we completed a follow-on registered direct
offering of our common stock that resulted in the sale of 1,625,000 shares, in the aggregate, of our common stock at a purchase price of $2.00 per share, and five year warrants to purchase an additional 568,750 shares of our common stock at an
exercise price of $2.00. The warrants were fully exercisable when issued. We received gross proceeds of approximately $3,250,000, before placement agent fees and offering expenses of approximately $224,000. In addition, we issued warrants to
purchase 97,500 shares of our common stock to the placement agent. These warrants have an exercise price of $2.29 and otherwise have substantially the same terms as the warrants issued to investors.

On July 18, 2008, we completed a second follow-on registered direct offering of our common stock that resulted in the sale of 1,670,000 shares, in the aggregate, of
our common stock at a purchase price of $2.00 per share, and five year warrants to purchase an additional 584,500 shares of our common stock at an exercise price of $2.00. The warrants were fully exercisable when issued. We received gross proceeds
of approximately $3,340,000, before placement agent fees, offering expenses and expense reimbursements of approximately $330,000. In addition, we issued warrants to purchase 100,200 shares of our common stock to the placement agent. These warrants
have an exercise price of $2.20 and otherwise have substantially the same terms as the warrants issued to investors.

Option Activity

We have an equity incentive plan that was established in 2005 under which 5,665,856 shares of our common stock have been reserved for issuance to employees, non-employee
directors and consultants of the Company.

During the nine months ended September 30, 2008, options to purchase 647,500 shares were granted under the
plan. The options granted during the nine months ended September 30, 2008 have an average exercise price of $2.25, with a term of seven years, and vest over four years. During the nine months ended September 30, 2008, vested options to
purchase 7,811 shares of our common stock expired and unvested options to purchase an additional 214,719 shares of our common stock were cancelled and are available for future issuance under the plan. Warrants to purchase 37,585 shares which had
been granted outside the plan were cancelled and 37,832 shares expired during the nine months ended September 30, 2008.



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##### Table of Contents

The following is a summary of stock option activity under our equity incentive plan and warrants issued outside of the
plan to employees and consultants, during the nine months ended September 30, 2008:



|                                        |  |                             |   |  |                              |      |                                                   |     |                         |   |    
|--------------------------------------- |  | --------------------------- | - |  | ---------------------------- | ---- | ------------------------------------------------- | --- | ----------------------- | - | ---
|                                        |  | Number ofOptions orWarrants |   |  | WeightedAverageExercisePrice |      | WeightedAverageRemainingContractualLife(in years) |     | AggregateIntrinsicValue
|Balance outstanding, December 31, 2007  |  | 5,491,500                   |   |  | $                            | 2.30 |                                                   | 7.3 |                         | $ |   
|Granted                                 |  | 647,500                     |   |  |                              | 2.25 |                                                   | 6.7 |                         |   |   
|Exercised                               |  |                            |   |  |                              |     |                                                   |    |                         |   |   
|Expired (vested)                        |  | (45,643                     | ) |  |                              | 2.57 |                                                   | 5.0 |                         |   |   
|Cancelled (unvested)                    |  | (252,304                    | ) |  |                              | 2.10 |                                                   | 7.1 |                         |   |   
|                                        |  |                             |   |  |                              |      |                                                   |     |                         |   |    
|Balance outstanding, September 30, 2008 |  | 5,841,053                   |   |  | $                            | 2.30 |                                                   | 6.6 |                         | $ | 0.0
|                                        |  |                             |   |  |                              |      |                                                   |     |                         |   |    
|Exercisable, September 30, 2008         |  | 3,941,581                   |   |  |                              | 2.22 |                                                   |     |                         |   |    
|                                        |  |                             |   |  |                              |      |                                                   |     |                         |   |    

The following is a summary of unvested options and warrants as of September 30, 2008, and changes during the
nine months ended September 30, 2008.



|                                                 |  |                             |   |  |                                     |     
|------------------------------------------------ |  | --------------------------- | - |  | ----------------------------------- | ----
|                                                 |  | Number ofOptions orWarrants |   |  | WeightedAverageGrant DateFair Value
|Unvested balance outstanding, December 31, 2007  |  | 2,733,198                   |   |  | $                                   | 1.48
|Granted                                          |  | 647,500                     |   |  |                                     | 1.45
|Vested                                           |  | (1,183,279                  | ) |  |                                     | 1.28
|Expired (vested)                                 |  | (45,643                     | ) |  |                                     | 1.48
|Cancelled (unvested)                             |  | (252,304                    | ) |  |                                     | 1.25
|                                                 |  |                             |   |  |                                     |     
|Unvested balance outstanding, September 30, 2008 |  | 1,899,472                   |   |  | $                                   | 1.48
|                                                 |  |                             |   |  |                                     |     

Warrants

On
January 31, 2008, we completed a registered direct offering of our common stock that resulted in the sale of 2,655,000 shares, in the aggregate, of our common stock at a purchase price of $2.00 per share, and five year warrants to purchase an
additional 929,250 shares of our common stock at an exercise price of $2.00. The warrants were fully exercisable when issued. In addition, we issued warrants to purchase 159,300 shares of our common stock to the placement agent on substantially the
same terms as the warrants issued to investors.

On June 27, 2008, we completed a follow-on registered direct offering of our common stock that
resulted in the sale of 1,625,000 shares, in the aggregate, of our common stock at a purchase price of $2.00 per share, and five year warrants to purchase an additional 568,750 shares of our common stock at an exercise price of $2.00. The warrants
were fully exercisable when issued. In addition, we issued warrants to purchase 97,500 shares of our common stock to the placement agent. These warrants have an exercise price of $2.29 and otherwise have substantially the same terms as the warrants
issued to investors.



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##### Table of Contents

On July 18, 2008, we completed a second follow-on registered direct offering of our common stock that resulted in
the sale of 1,670,000 shares, in the aggregate, of our common stock at a purchase price of $2.00 per share, and five year warrants to purchase an additional 584,500 shares of our common stock at an exercise price of $2.00. The warrants were fully
exercisable when issued. In addition, we issued warrants to purchase 100,200 shares of our common stock to the placement agent. These warrants have an exercise price of $2.20 and otherwise have substantially the same terms as the warrants issued to
investors.

The following table summarizes warrant activity for the nine months ended September 30, 2008:



|                                           |  |                   |   |  |                |              |                                                   |      
|------------------------------------------ |  | ----------------- | - |  | -------------- | ------------ | ------------------------------------------------- | -----
|                                           |  | Number ofWarrants |   |  | Exercise Price |              | WeightedAverageRemainingContractualLife(in years)
|Balance outstanding, December 31, 2007     |  | 5,701,610         |   |  | $              | 1.50 - $3.78 |                                                   | 2 -4 
|Warrants issued                            |  | 2,439,500         |   |  |                | 2.00 - 2.29  |                                                   | 5    
|Warrants exercised                         |  | (40,000           | ) |  |                | 1.50         |                                                   | 2    
|Warrants expired                           |  |                  |   |  |                |             |                                                   |     
|Warrants cancelled                         |  |                  |   |  |                |             |                                                   |     
|                                           |  |                   |   |  |                |              |                                                   |      
|Balance outstanding, September 30, 2008    |  | 8,101,110         |   |  | $              | 1.50  3.78  |                                                   | 1  5
|                                           |  |                   |   |  |                |              |                                                   |      
|Warrants exercisable at September 30, 2008 |  | 8,101,110         |   |  | $              | 1.50  3.78  |                                                   | 1  5
|                                           |  |                   |   |  |                |              |                                                   |      

The table above does not include warrants issued to employees and consultants described and included under
Option Activity above.

Note 7. Long-Term Debt

On November 12, 2007, Cardium, InnerCool Therapies and Tissue Repair Company entered into a Loan and Security Agreement with Life Sciences Capital, LLC, whereby we obtained debt financing in the principal amount of $5 million to
be used for general working capital purposes. In connection with the loan, we paid Life Sciences Capital, LLC a loan commitment fee and related legal expenses of $108,500, which was capitalized as deferred financing costs and amortized over the term
of the loan. On July 1, 2008 we paid off the principal balance on our commercial credit facility out of the proceeds from the June 2008 offering, thereby retiring our remaining debt obligations to Life Sciences Capital.

Note 8. Subsequent Events

On November 10, 2008, we completed a $6
million financing in the form of secured debt with accompanying warrants to purchase nine million shares of common stock. This obligation is secured by our assets and intellectual property, has a one year term and bears interest at a fixed rate
of 12% per annum. The warrants were fully exercisable when issued, have a five year term and an exercise price of $2.00. We expect to receive gross proceeds of approximately $6 million (which includes $845,000 previously advanced to the Company in
the form of advances and salary deferral by the Companys chief executive officer, chief business officer, chief scientific officer and chief medical advisor, that were contributed to the purchase of notes), less placement agent fees and
offering expenses. In addition, we issued warrants to purchase 386,625 shares of common stock to the placement agent on substantially the same terms as the warrants issued to the lenders.



|ITEM 2. | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
|------- | -------------------------------------------------------------------------------------

The following discussion and analysis is intended to help you understand our financial condition and results of operations for the three and nine months ended September 30, 2008. You should read the following
discussion and analysis together with our unaudited condensed consolidated financial statements and the notes to the condensed consolidated financial statements included under Item 1 in this report, as well as the risk factors and other
information included in our 2007 Annual Report and other reports and documents we file with the United States Securities and Exchange Commission (SEC). Our future financial condition and results of operations will vary from our historical financial
condition and results of operations described below.



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##### Table of Contents

Executive Overview

The following overview does not address all of the matters covered in the other sections of this Item 2 or other items in this report or contain all of the information that may be important to our stockholders or the investing
public. This overview should be read in conjunction with the other sections of this Item 2 and this report.

We are a medical technology company
primarily focused on the development, manufacture and sale of innovative therapeutic products and devices for cardiovascular, ischemic and related indications. Building upon our core products and product candidates, our strategic goal is to develop
a portfolio of medical products at various stages of development and secure additional financial resources to commercialize these products in a timely and effective manner. To that end, on January 31, 2008, we closed a $5.3 million registered
direct offering to provide funding to further develop our ongoing programs, as well as for other general corporate purposes. On June 27, 2008, we closed a $3.25 million follow-on registered direct offering, the proceeds of which were primarily
used to pay off the principal balance on our commercial credit facility. On July 18, we closed a $3.34 million follow-on registered direct offering, the proceeds of which were primarily used to fund current operations.

As a development stage company, our revenues are generally limited to those generated by the sale of InnerCools endovascular system and its new CoolBlue surface
temperature modulation system and its RapidBlue system. We do not have any other products available for sale or use. Because of the limited nature of our revenues and the high costs we must incur to develop our product candidates, we have yet to
generate positive cash flows or income from operations and do not anticipate doing so in the foreseeable future. As a result, we are currently dependent on debt and equity funding to finance our operations.

Going forward, the key elements of our strategy are to:



| |  |  | advance the Phase 2b clinical study for Excellarate;
| | - |  | ----------------------------------------------------



| |  |  | accelerate the commercialization of InnerCools Rapid Blue SystemTMand, at the same time, expand our CoolBlue product placements and broaden and expand our therapeutic hypothermia technology into other medical indications and applications;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | advance the Phase 3 AWARE clinical study for Generx;
| | - |  | ----------------------------------------------------



| |  |  | leverage our financial resources and focused corporate infrastructure through the use of contract manufacturers to produce clinical supplies and a contract research
organization to manage or assist planned clinical studies;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | advance the pre-clinical development of Corgentin and potentially seek partnering opportunities for the Corgentin and Genvascor product candidates;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | broaden and expand our product base and financial resources through other corporate development transactions in an attempt to enhance stockholder value, which could
include acquiring other medical-related companies or product opportunities and/or securing additional capital; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | monetize the economic value of our product portfolio by establishing strategic collaborations and selling businesses and assets at appropriate valuation inflection
points.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We plan to continue to build our business through internal development and external acquisitions. As an emerging public company,
we have initially focused on acquiring undervalued opportunities having unrealized value but which we believe have potential for significant future growth and development or partnering prospects when combined with the skills and perspectives of our
experienced management team.

We intend to continue to pursue opportunistic acquisitions designed to enhance long-term stockholder value. At the same time,
to the extent our technologies and product candidates are advanced and businesses are built-up, further developed and mature, we may consider various corporate development transactions to enhance and monetize stockholder value such as corporate
partnerings, spin-out transactions and equity distribution.

We recognize that the practical realities of developing therapeutic products in the current
regulatory environment require sizable financial investment. In view of this, we plan to pursue clinical development strategies intended to facilitate collaborations and partnerships for joint development of our products at appropriate valuation
inflection points during their clinical development cycle.

More detailed information about our products, product candidates, our intended efforts to
develop our products and our business strategy is included in our 2007 Annual Report.



11



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Critical Accounting Policies and Estimates

The preparation of our financial statements requires that we make estimates and assumptions that affect the amounts reported in our financial statements and their accompanying notes. We have identified certain
policies that we believe are important to the portrayal of our financial condition and results of operations. These policies require the application of significant judgment by our management. We base our estimates on our historical experience,
industry standards, and various other assumptions that we believe are reasonable under the circumstances. Actual results could differ from these estimates under different assumptions or conditions. An adverse effect on our financial condition,
changes in financial condition, and results of operations could occur if circumstances change that alter the various assumptions or conditions used in such estimates or assumptions.

Our significant accounting policies are described under Item 7 of our 2007 Annual Report and in the notes to the condensed consolidated financial statements included in this report.

Results of Operations

Three months ended September 30, 2008
compared to September 30, 2007

Product sales for the three months ended September 30, 2008 were $585,421 compared to sales of $306,992 for
the three months ended September 30, 2007. The increase of $278,429 was due in large part to an increase in sales of InnerCool Therapies Celsius Control System resulting from our expanded sales and marketing efforts at InnerCool
Therapies, as well as new sales from the launch of InnerCool Therapies CoolBlue system in late 2007. There was no grant revenue for the three months ended September 30, 2008 compared to grant revenues of $57,338 for the three months ended
September 30, 2007. The decrease of $57,338 was attributed to no grant expenditures during the third quarter of 2008.

Cost of goods sold for the
three months ended September 30, 2008 was $514,243 compared to $318,934 for the three months ended September 30, 2007. The increase of $195,309 was due to an increase in the products being sold during the three months ended
September 30, 2008, along with increases in production costs.

Research and development expenses for the three months ended September 30, 2008
were $2,947,997 compared to $3,243,008 for the same three month period last year. The decrease of $295,011 was primarily due a reduction in the development costs for InnerCools RapidBlue product as it has moved from development to production,
increased expenses in our efforts to advance our Excellarate product candidate in its Phase 2b clinical trial, offset by reductions in Generx (AWARE) Phase 3 clinical trial costs as spending in the three months ended September 30, 2007 included
product material and initial start-up costs not required in the recent three month period.

Selling, general and administrative expenses for the three
months ended September 30, 2008 were $2,886,089 compared to $2,838,949 for the three months ended September 30, 2007. The increase of $47,140 for the three month period was primarily due to increases in the sales efforts at Innercool
including major advertising expense, offset by reductions in printing and stock exchange filing fees. The increase was also due to higher rent expense resulting from the relocation of our corporate headquarters as the lease for our prior facility
was due to expire and we had no renewal option.

Amortization of intangibles for the three months ended September 30, 2008 was $197,414, as compared
to $178,156 recorded in the three months ended September 30, 2007. The increase of $19,258 was a result of an adjustment in the amount of amortization due to the reclassification of some costs between the recorded patented technology and other
intangibles in connection with our acquisition of InnerCool Therapies.

We derive interest income from the investment of our available cash in various
short-term obligations, such as certificates of deposit, commercial paper and money market funds. Interest income for the three months ended September 30, 2008 was $8,028 compared to $146,748 for the same three month period last year. The
$138,720 decrease in interest income for the three month period when compared to the same period last year was related to the decrease in cash and cash equivalents available for investment during the respective periods and lower interest rates.

Interest expense for the three months ended September 30, 2008 was $199,221 as a result of our commercial credit facility with Life Sciences Capital
LLC. There was no interest expense recorded during the three months ended September 30, 2007 as the commercial credit facility with Life Sciences Capital was not obtained until November 12, 2007.

Nine months ended September 30, 2008 compared to September 30, 2007

Product sales for the nine months ended September 30, 2008 were $1,483,631 compared to $771,762 for the nine months ended September 30, 2007. The increase of $711,869 was due in large part to an increase in sales of InnerCool
Therapies Celsius Control System resulting from our expanded sales and marketing efforts at InnerCool Therapies, as well as new sales from the launch of InnerCool Therapies CoolBlue system in late 2007. For the nine months ended
September 30, 2008, grant revenues were $374,633 compared to grant revenues of $131,371 for the nine months ended September 30, 2007. The increase of $243,262 in grant revenues is reflective of the level of activity as we sought to ramp up
our preclinical study activities in 2008.



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Cost of goods sold for the nine months ended September 30, 2008 were $1,199,193 compared to $823,676 for the nine
months ended September 30, 2007. The increase of $375,517 in cost of goods sold was directly related to the increase in revenues from the sale of InnerCool Therapies products.

Research and development expenses for the nine months ended September 30, 2008 were $10,289,883 compared to $9,901,087 for the nine months ended September 30, 2007. The increase of $388,796 was primarily due
to our efforts to advance our Excellarate product candidate in its Phase 2b clinical trial, including a $500,000 product advancement milestone payment and the accrual of the final $500,000 product advancement milestone payment payable in February
2009, and development costs for InnerCools RapidBlue product as it has moved from development to production, offset by reductions in Generx (AWARE) Phase 3 clinical trial costs as spending in the nine months ended September 30, 2007
included initial product material and start-up costs not required in the recent nine month period, and a $500,000 reversal of bonuses that were accrued at the end of 2007 and not paid. As of December 31, 2007, the Company recorded a liability
for discretionary employee and officer bonuses for past performance. The payment of such bonuses was expected to take place sometime in 2008. Given the ongoing difficulties in the financial markets, which made it more challenging and expensive for
companies to raise funds, the compensation committee felt it appropriate to forego the planned payment of these bonuses.

Selling, general and
administrative expenses for the nine months ended September 30, 2008, were $8,968,214 compared to $8,356,498 for the nine months ended September 30, 2007. The increase of $611,716 in selling, general and administrative expenses was
primarily due to our expanded sales and marketing efforts at InnerCool, rent expense, professional fees and increases in headcount, offset by the reversal of $700,000 in bonuses that were accrued at the end of 2007 and not paid, as noted above.

Interest income for the nine months ended September 30, 2008 was $95,664 compared to $461,371 for the nine months ended September 30, 2007. The
$365,707 decrease in interest income was related to the decrease in cash and cash equivalents available for investment during the respective periods and lower interest rates.

Interest expense for the nine months ended September 30, 2008 was $424,501 as a result of our commercial credit facility with Life Sciences Capital LLC. There was no interest expense recorded during the nine
months ended September 30, 2007 as the commercial credit facility with Life Sciences Capital was not obtained until November 12, 2007.

Liquidity and Capital Resources

Our primary source of liquidity has been cash flows from financing activities and in particular proceeds
from the sale of our common stock. Net cash provided by financing activities was $6,086,893 for the nine months ended September 30, 2008, and was primarily derived from proceeds we received from the sale of our common stock, net of issuance
costs. For the nine months ended September 30, 2007, net cash provided by financing activities was $20,119,639 and for the period December 22, 2003 (inception) to September 30, 2008, net cash provided by financing activities was
$58,154,217. Net cash used in operating activities was $12,059,610 for the nine months ended September 30, 2008 compared to $15,719,691 for the same nine month period last year. The decrease in net cash used in operating activities was due
primarily to an increase in accounts payable and other accrued liabilities at September 30, 2008. Cash used in investing activities was $1,623,524 for the nine months ended September 30, 2008 compared to $1,077,113 for the nine months
ended September 30, 2007. The increase of $546,411 was due to a $500,000 product advancement milestone payment and the accrual of the final $500,000 product advancement milestone payment payable in February 2009, offset by a reduction in the
purchase of property and equipment.

Since inception, our operations have consumed substantial amounts of cash and we have had only limited revenues. We
anticipate that the negative cash flow from operations will continue. On January 31, 2008, we completed a registered direct offering of our common stock that resulted in net proceeds to the Company of approximately $5 million. On June 27,
2008, we completed a follow-on registered direct offering of our common stock that resulted in net proceeds to the Company of approximately $3 million. On July 1, 2008 we paid off the principal balance on our commercial credit facility out of
the proceeds from the June 2008 offering. On July 18, 2008, we completed a second registered direct offering for which we received net proceeds of approximately $3 million.

As of September 30, 2008, we had $126,575 in cash and cash equivalents. On November 10, 2008, we completed a secured debt financing for which we received proceeds of approximately $6 million before placement
agent fees and offering expenses (see Note 8). With the completion of our recent debt offering, we believe we will be able to fund required operations for approximately the next three months, not including efforts to accelerate the study of our
Generx and Excellarate product candidates and actively promote the launches of InnerCools CoolBlue and RapidBlue product lines. As a result, we will need to raise additional funds through the sale of equity securities, debt financings,
strategic licensing agreements and/or other corporate transactions. If we do not raise such funds, we will not be able to accelerate our product development activities or maintain operations. Management has been in discussions to raise additional
funds but there is no assurance we will succeed in these efforts. If we are not successful in obtaining additional funds,



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we will need to scale back our operations and/or sell or partner certain development projects or products, or our operations may not be able to continue as
planned or at all. The previously described conditions raise substantial doubt about the Companys ability to continue as a going concern. The condensed consolidated financial statements do not include any adjustments related to the
recoverability of assets or classifications of liabilities that might be necessary should we be unable to continue as a going concern.

Off-Balance
Sheet Arrangements

As of September 30, 2008, we did not have any significant off-balance sheet debt nor did we have any transactions,
arrangements, obligations (including contingent obligations) or other relationships with any unconsolidated entities or other persons that have or are reasonably likely to have a material current or future effect on financial condition, changes in
financial condition, results of operations, liquidity, capital expenditures, capital resources, or significant components of revenue or expenses material to investors. As of September 30, 2008, we had operating lease obligations of
approximately $4,236,921 extending through 2013.

Special Note About Forward-Looking Statements

Certain statements in this report, including information incorporated by reference, are forward-looking statements within the meaning of Section 27A of
the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934, and the Private Securities Litigation Reform Act of 1995. Forward-looking statements reflect current views about future events and financial performance based on
certain assumptions. They include opinions, forecasts, intentions, plans, goals, projections, guidance, expectations, beliefs or other statements that are not statements of historical fact. Words such as may, will,
should, could, would, expects, plans, believes, anticipates, intends, estimates, approximates, predicts, or
projects, or the negative or other variation of such words, and similar expressions may identify a statement as a forward-looking statement. Any statements that refer to projections of our future financial performance, our anticipated
growth and trends in our business, our goals, strategies, focus and plans, and other characterizations of future events or circumstances, including statements expressing general optimism about future operating results and the development of our
products, are forward-looking statements. Forward-looking statements in this report may include statements about:



| |  |  | future financial and operating results;
| | - |  | ---------------------------------------



| |  |  | our ability to fund operations and business plans, and the timing of any funding we obtain;
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | the timing, conduct and outcome of discussions with regulatory agencies, regulatory submissions and clinical trials and product launches;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the performance of GenerxTM, InnerCool Therapies Celsius Control SystemTMand RapidBlueTMand CoolBlueTMsystems, ExcellarateTM, and other product candidates and their potential to attract development partners and/or generate revenues;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our beliefs and opinions about the safety and efficacy of our products and product candidates and the results of our clinical studies and trials;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the development or commercialization of competitive products or medical procedures;
| | - |  | -----------------------------------------------------------------------------------



| |  |  | our development of new products and product candidates;
| | - |  | -------------------------------------------------------



| |  |  | our growth, expansion and acquisition strategies, the success of such strategies, and the benefits we believe can be derived from such strategies;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the outcome of litigation matters;
| | - |  | ----------------------------------



| |  |  | our intellectual property rights and those of others, including actual or potential competitors;
| | - |  | ------------------------------------------------------------------------------------------------



| |  |  | the ability to enter into acceptable relationships with one or more contract manufacturers or other service providers on which we may depend and the ability of such
contract manufacturers or other service providers to manufacture biologics or devices or to provide services of an acceptable quality on a cost-effective basis;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our personnel, consultants and collaborators;
| | - |  | ---------------------------------------------



| |  |  | operations outside the United States;
| | - |  | -------------------------------------



| |  |  | current and future economic and political conditions;
| | - |  | -----------------------------------------------------



| |  |  | overall industry and market performance;
| | - |  | ----------------------------------------



| |  |  | the impact of accounting pronouncements;
| | - |  | ----------------------------------------



| |  |  | managements goals and plans for future operations; and
| | - |  | -------------------------------------------------------



| |  |  | other assumptions described in this report underlying or relating to any forward-looking statements.
| | - |  | ----------------------------------------------------------------------------------------------------



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The forward-looking statements in this report speak only as of the date of this report and caution should be taken not to
place undue reliance on any such forward-looking statements. Forward-looking statements are subject to certain events, risks, and uncertainties that may be outside of our control. When considering forward-looking statements, you should carefully
review the risks, uncertainties and other cautionary statements in this report as they identify certain important factors that could cause actual results to differ materially from those expressed in or implied by the forward-looking statements.
These factors include, among others, the risks described under Item 1A of Part II and elsewhere in this report and in our 2007 Annual Report, as well as in other reports and documents we file with the SEC.

Unless the context requires otherwise, all references in this report to the Company, Cardium, we, our, and us
refer to Cardium Therapeutics, Inc. and, as applicable, InnerCool Therapies, Inc. and Tissue Repair Company, each a wholly-owned subsidiary of Cardium.



|ITEM 3. | QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
|------- | ----------------------------------------------------------

We are
exposed to a limited level of market risk, which is the potential loss arising from adverse changes in market rates and prices, such as interest rates, due to the investment of our available cash and cash equivalents in various instruments.

The goal of our investment activities is to preserve principal while seeking to increase income received on our investments without significantly
increasing risk. In the normal course of business, we employ established policies and procedures to manage our exposure to changes in the fair value of our investments. We generally do not, however, enter into derivatives or other financial
instruments for trading or speculative purposes or to otherwise manage our exposure to interest rate changes. Generally, we seek to limit our exposure to risk by investing substantially in short-term, investment grade securities, such as commercial
paper, certificates of deposit and money market funds. The amount of interest income we receive on our investments will vary with changes in the general level of interest rates in the United States, generally decreasing as interest rates decrease
and increasing as interest rates increase.

While we cannot predict with any certainty our future exposure to fluctuations in interest rates or other
market risks or the impact, if any, such fluctuations may have on our future business, consolidated financial condition, results of operations or cash flows, due to the short-term, investment grade nature of our investments, we do not believe our
exposure to market risk from our investments is material.



|ITEM 4. | CONTROLS AND PROCEDURES
|------- | -----------------------

We maintain certain disclosure controls
and procedures. They are designed to help ensure that material information is: (1) gathered and communicated to our management, including our principal executive and financial officers, on a timely basis; and (2) recorded, processed,
summarized, reported and filed with the SEC as required under the Securities Exchange Act of 1934, as amended.

Our management, with the participation of
our Chief Executive Officer and Chief Financial Officer, evaluated the effectiveness of our disclosure controls and procedures as of September 30, 2008. Based on such evaluation, our Chief Executive Officer and Chief Financial Officer concluded
that our disclosure controls and procedures were effective for their intended purpose described above.

There were no changes to our internal control over
financial reporting during the quarterly period ended September 30, 2008 that have materially affected, or that are reasonably likely to materially affect, our internal control over financial reporting.



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##### Table of Contents

PART II  OTHER INFORMATION



|ITEM 1. | LEGAL PROCEEDINGS
|------- | -----------------

From time to time, we may become
involved in various investigations, claims and legal proceedings that arise in the ordinary course of our business. These matters may relate to intellectual property, employment, tax, regulation, contract or other matters. The resolution of these
matters as they arise will be subject to various uncertainties and, even if such claims are without merit, could result in the expenditure of significant financial and managerial resources.

As of November 7, 2008, neither Cardium nor its subsidiaries were a party to any pending legal proceeding considered material to their businesses
nor was any of their property the subject of any material pending legal proceeding. We anticipate, however, that we will be regularly engaged in various patent prosecution and related matters in connection with the technology we develop and/or
license. To the extent we are not successful in defending against any adverse claims concerning our technology, we could be compelled to seek licenses from one or more third parties who could be direct or indirect competitors and who might not make
licenses available on terms that we find commercially reasonable or at all. In addition, any such proceedings, even if decided in our favor, involve lengthy processes, are subject to appeals, and typically result in substantial costs and diversion
of resources.



|ITEM 1A. | RISK FACTORS
|-------- | ------------

There have been no material changes from the risk
factors previously disclosed in our 2007 Annual Report. You should carefully consider the risks described under Item 1A of our 2007 Annual Report, as well as the other information in our 2007 Annual Report, this report and other reports and
documents we file with the SEC, when evaluating our business and future prospects. If any of the identified risks actually occur, our business, financial condition and results of operations could be seriously harmed. In that event, the market price
of our common stock could decline and you could lose all or a portion of the value of your investment in our common stock.



|ITEM 2. | UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS
|------- | -----------------------------------------------------------

During
the quarterly period ended September 30, 2008, we did not sell any unregistered securities.



|ITEM 3. | DEFAULTS UPON SENIOR SECURITIES
|------- | -------------------------------

None.



|ITEM 4. | SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
|------- | ---------------------------------------------------

None.



|ITEM 5. | OTHER INFORMATION
|------- | -----------------

None.



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|ITEM 6. | EXHIBITS
|------- | --------

The following exhibit index shows those exhibits filed
with this report and those incorporated by reference:

EXHIBIT INDEX



|              |  |                                                                                                                                                                                                |  |                                                                                                                                         
|------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                    |  | Incorporated By Reference To                                                                                                            
|              |  |                                                                                                                                                                                               
|2.1           |  | Agreement and Plan of Merger dated as of October 19, 2005 and effective as of October 20, 2005, by and among Aries Ventures Inc., Aries Acquisition Corporation and Cardium Therapeutics, Inc. |  | Exhibit 2.1 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                     
|              |  |                                                                                                                                                                                               
|2.2           |  | Certificate of Merger of Domestic Corporation as filed with the Delaware Secretary of State on October 20, 2005                                                                                |  | Exhibit 2.1 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                     
|              |  |                                                                                                                                                                                               
|2.3           |  | Agreement and Plan of Merger dated January 17, 2006, between Aries Ventures Inc. and Cardium Therapeutics, Inc.                                                                                |  | Exhibit 2.4 of our Registration Statement on Form SB-2 (File No. 333-131104), filed with the commission on January 18, 2006             
|              |  |                                                                                                                                                                                               
|2.4           |  | Certificate of Merger, as filed with the Delaware Secretary of State on January 17, 2006                                                                                                       |  | Exhibit 2.5 of our Registration Statement on Form SB-2 (File No. 333-131104), filed with the commission on January 18, 2006             
|              |  |                                                                                                                                                                                               
|3(i)          |  | Second Amended and Restated Certificate of Incorporation of Cardium Therapeutics, Inc. as filed with the Delaware Secretary of State on January 13, 2006                                       |  | Exhibit 3(i) of our Registration Statement on Form SB-2 (File No. 333-131104), filed with the commission on January 18, 2006            
|              |  |                                                                                                                                                                                               
|3(ii)         |  | Amended and Restated Bylaws of Cardium Therapeutics, Inc. as adopted on January 12, 2006                                                                                                       |  | Exhibit 3(ii) of our Registration Statement on Form SB-2 (File No. 333-131104), filed with the commission on January 18, 2006           
|              |  |                                                                                                                                                                                               
|3(iii)        |  | Certificate of Designation of Series A Junior Participating Preferred Stock                                                                                                                    |  | Exhibit 3.2 of our Registration Statement on Form 8-A, filed with the commission on July 11, 2006                                       
|              |  |                                                                                                                                                                                               
|4.1           |  | Form of Warrant issued to employees and consultants of InnerCool Therapies, Inc.                                                                                                               |  | Exhibit 4.1 of our Current Report on Form 8-K dated March 8, 2006, filed with the commission on March 14, 2006                          
|              |  |                                                                                                                                                                                               
|4.2           |  | Form of Common Stock Certificate for Cardium Therapeutics, Inc.                                                                                                                                |  | Exhibit 4.5 of our Annual Report on Form 10-KSB for the fiscal year ended December 31, 2005, filed with the commission on March 31, 2006
|              |  |                                                                                                                                                                                               
|4.3           |  | Form of Rights Agreement dated as of July 10, 2006, between Cardium Therapeutics, Inc. and Computershare Trust Company, Inc., as Rights Agent                                                  |  | Exhibit 4.1 of our Registration Statement on Form 8-A, filed with the commission on July 11, 2006                                       
|              |  |                                                                                                                                                                                               
|4.4           |  | Form of Rights Certificate                                                                                                                                                                     |  | Exhibit 4.2 of our Registration Statement on Form 8-A, filed with the commission on July 11, 2006                                       
|              |  |                                                                                                                                                                                               
|4.5           |  | Form of Warrant issued to purchasers in 2007 private financing                                                                                                                                 |  | Exhibit 4.1 of our Current Report on Form 8-K dated March 6, 2007, filed with the commission on March 6, 2007                           



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##### Table of Contents

|              |  |                                                                                                                                                                                                                                    |  |                                                                                                                                         
|------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                                                        |  | Incorporated By Reference To                                                                                                            
|              |  |                                                                                                                                                                                                                                   
|4.6           |  | Form of Warrant issued to Oppenheimer & Co. Inc. as Placement Agent in 2007 private financing                                                                                                                                      |  | Exhibit 4.7 of our Annual Report on Form 10-KSB for the fiscal year ended December 31, 2006, filed with the commission on March 15, 2007
|              |  |                                                                                                                                                                                                                                   
|4.7           |  | Form of Warrant issued to purchasers in January 2008 registered direct offering                                                                                                                                                    |  | Exhibit 4.1 of our Current Report on Form 8-K dated January 30, 2008, filed with the commission on January 31, 2008                     
|              |  |                                                                                                                                                                                                                                   
|4.8           |  | Form of Warrant issued to purchasers in June 2008 registered direct offering                                                                                                                                                       |  | Exhibit 4.1 of our Current Report on Form 8-K dated June 27, 2008, filed with the commission on June 30, 2008                           
|              |  |                                                                                                                                                                                                                                   
|4.9           |  | Form of Warrant issued to Empire Asset Management Company in June 2008 registered direct offering                                                                                                                                  |  | Exhibit 4.2 of our Current Report on Form 8-K dated June 27, 2008, filed with the commission on June 30, 2008                           
|              |  |                                                                                                                                                                                                                                   
|4.10          |  | Form of Warrant issued to purchasers in July 2008 registered direct offering                                                                                                                                                       |  | Exhibit 4.1 of our Current Report on Form 8-K dated July 18, 2008, filed with the commission on July 21, 2008                           
|              |  |                                                                                                                                                                                                                                   
|4.11          |  | Form of Warrant issued to Empire Asset Management Company in July 2008 registered direct offering                                                                                                                                  |  | Exhibit 4.2 of our Current Report on Form 8-K dated July 18, 2008, filed with the commission on July 21, 2008                           
|              |  |                                                                                                                                                                                                                                   
|10.1          |  | Transfer, Consent to Transfer, Amendment and Assignment of License Agreement effective as of August 31, 2005, by and among New York University, Collateral Therapeutics, Inc. and Cardium
Therapeutics, Inc.                       |  | Exhibit 10.1 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                    
|              |  |                                                                                                                                                                                                                                   
|10.2          |  | Transfer, Consent to Transfer, Amendment and Assignment of License Agreement effective as of August 31, 2005, by and among Yale University, Schering Aktiengesellschaft and Cardium
Therapeutics, Inc.                             |  | Exhibit 10.2 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                    
|              |  |                                                                                                                                                                                                                                   
|10.3          |  | Transfer, Consent to Transfer, Amendment and Assignment of License Agreement effective as of July 31, 2005, by and among the Regents of the University of California, Collateral
Therapeutics, Inc. and Cardium Therapeutics, Inc. |  | Exhibit 10.3 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                    
|              |  |                                                                                                                                                                                                                                   
|10.4          |  | Transfer, Consent to Transfer, Amendment and Assignment of License Agreement effective as of July 31, 2005, by and among the Regents of the University of California, Collateral Therapeutics,
Inc. and Cardium Therapeutics, Inc. |  | Exhibit 10.4 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                    
|              |  |                                                                                                                                                                                                                                   
|10.5          |  | Technology Transfer Agreement effective as of October 13, 2005, by and among Schering AG, Berlex, Inc., Collateral Therapeutics, Inc. and Cardium Therapeutics, Inc.                                                               |  | Exhibit 10.5 of Aries Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                 
|              |  |                                                                                                                                                                                                                                   
|10.6          |  | Amendment to the Exclusive License Agreement for Angiogenesis Gene Therapy effective as of October 20, 2005, between the Regents of the University of California and Cardium
Therapeutics, Inc.                                  |  | Exhibit 10.6 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                    
|              |  |                                                                                                                                                                                                                                   
|10.7          |  | Amendment to License Agreement effective as of October 20, 2005, by and between New York University and Cardium Therapeutics, Inc.                                                                                                 |  | Exhibit 10.7 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                    
|              |  |                                                                                                                                                                                                                                   
|10.8          |  | Second Amendment to Exclusive License Agreement effective as of October 20, 2005, by and between Yale University and Cardium Therapeutics, Inc.                                                                                    |  | Exhibit 10.8 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                    
|              |  |                                                                                                                                                                                                                                   
|10.9          |  | 2005 Equity Incentive Plan as adopted effective as of October 20, 2005*                                                                                                                                                            |  | Exhibit 10.9 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                    
|              |  |                                                                                                                                                                                                                                   
|10.10         |  | Employment Agreement dated as of October 20, 2005 by and between Aries Ventures Inc. and Christopher Reinhard*                                                                                                                     |  | Exhibit 10.10 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                   



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|              |  |                                                                                                                                                                                                                                                                                 |  |                                                                                                                                               
|------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                                                                                                     |  | Incorporated By Reference To                                                                                                                  
|              |  |                                                                                                                                                                                                                                                                                
|10.11         |  | Employment Agreement dated as of October 20, 2005 by and between Aries Ventures Inc. and Tyler Dylan*                                                                                                                                                                           |  | Exhibit 10.11 of our Current Report on Form 8-K dated October 20, 2005, filed with the commission on October 26, 2005                         
|              |  |                                                                                                                                                                                                                                                                                
|10.12         |  | Yale Exclusive License Agreement between Yale University and Schering Aktiengesellschaft dated September 8, 2000                                                                                                                                                                |  | Exhibit 10.13 of our Annual Report on Form 10-KSB for the fiscal year ended September 30, 2005, filed with the commission on December 22, 2005
|              |  |                                                                                                                                                                                                                                                                                
|10.13         |  | Research and License Agreement between New York University and Collateral Therapeutics, Inc. dated March 24, 1997 (with amendments dated April 28, 1998 and March 24,
2000)                                                                                                     |  | Exhibit 10.14 of our Annual Report on Form 10-KSB for the fiscal year ended September 30, 2005, filed with the commission on December 22, 2005
|              |  |                                                                                                                                                                                                                                                                                
|10.14         |  | Exclusive License Agreement for Angiogenesis Gene Therapy between the Regents of the University of California and Collateral Therapeutics, Inc. dated as of September 27, 1995 (with
amendments dated September 19, 1996, June 30, 1997, March 11, 1999 and February 8, 2000) |  | Exhibit 10.15 of our Annual Report on Form 10-KSB for the fiscal year ended September 30, 2005, filed with the commission on December 22, 2005
|              |  |                                                                                                                                                                                                                                                                                
|10.15         |  | Asset Purchase Agreement dated as of March 8, 2006, by and among Cardium Therapeutics, Inc., InnerCool Therapies, Inc. (a Delaware corporation), and InnerCool Therapies, Inc. (a California
corporation) (without schedules)                                                   |  | Exhibit 10.1 of our Current Report on Form 8-K dated March 8, 2006, filed with the commission on March 14, 2006                               
|              |  |                                                                                                                                                                                                                                                                                
|10.16         |  | Executive Employment Agreement dated March 8, 2006 by and between InnerCool Therapies, Inc. and Michael Magers*                                                                                                                                                                 |  | Exhibit 10.19 of our Annual Report on Form 10-KSB for the fiscal year ended December 31, 2005, filed with the commission on March 31, 2006    
|              |  |                                                                                                                                                                                                                                                                                
|10.17         |  | Master License Agreement effective as of December 1, 1999, by and between SurModics, Inc. and InnerCool Therapies, Inc.                                                                                                                                                         |  | Exhibit 10.20 of our Annual Report on Form 10-KSB for the fiscal year ended December 31, 2005, filed with the commission on March 31, 2006    
|              |  |                                                                                                                                                                                                                                                                                
|10.18         |  | Asset Purchase Agreement dated as of August 11, 2006, by and among Cardium Therapeutics, Inc., Cardium Biologics, Inc. (a Delaware corporation), and Tissue Repair Company (a Delaware
corporation)                                                                             |  | Exhibit 10.26 of our Current Report on Form 8-K dated August 11, 2006, filed with the commission on August 15, 2006                           
|              |  |                                                                                                                                                                                                                                                                                
|10.19         |  | Form of Securities Purchase Agreement, dated March 6, 2007, by an between Cardium Therapeutics, Inc. and each purchaser in 2007 private financing (agreements on substantially this form were
signed by each purchaser in the financing)                                        |  | Exhibit 10.1 of our Current Report on Form 8-K dated March 6, 2007, filed with the commission on March 6, 2007                                
|              |  |                                                                                                                                                                                                                                                                                
|10.20         |  | Office Lease dated as of September 16, 2006 and commencing on January 20, 2007, by and between Cardium Therapeutics, Inc. and Jaguar Properties, L.L.C.                                                                                                                         |  | Exhibit 10.30 of our Annual Report on Form 10-KSB for the fiscal year ended December 31, 2006, filed with the commission on March 15, 2007    
|              |  |                                                                                                                                                                                                                                                                                
|10.21         |  | Michigan License agreement between the Regents of the University of Michigan and Matrigen, Inc. dated July 13, 1995                                                                                                                                                             |  | Exhibit 10.33 of our Annual Report on Form 10-KSB for the fiscal year ended December 31, 2006, filed with the commission on March 15, 2007    
|              |  |                                                                                                                                                                                                                                                                                
|10.22         |  | Amendment to License agreement between the Regents of the University of Michigan and Matrigen, Inc. dated August 10, 1995                                                                                                                                                       |  | Exhibit 10.34 of our Annual Report on Form 10-KSB for the fiscal year ended December 31, 2006, filed with the commission on March 15, 2007    



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|              |  |                                                                                                                                                                                                                                                                  |  |                                                                                                                                            
|------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                                                                                      |  | Incorporated By Reference To                                                                                                               
|              |  |                                                                                                                                                                                                                                                                 
|10.23         |  | Second Amendment to the Michigan License agreement between the Regents of the University of Michigan and Selective Genetics, Inc. dated February 1, 2004                                                                                                         |  | Exhibit 10.35 of our Annual Report on Form 10-KSB for the fiscal year ended December 31, 2006, filed with the commission on March 15, 2007 
|              |  |                                                                                                                                                                                                                                                                 
|10.24         |  | Third Amendment to Michigan License Agreement between the Regents of the University of Michigan, and Tissue Repair Company, and Cardium Biologics Inc. dated August 10, 2006                                                                                     |  | Exhibit 10.36 of our Annual Report on Form 10-KSB for the fiscal year ended December 31, 2006, filed with the commission on March 15, 2007 
|              |  |                                                                                                                                                                                                                                                                 
|10.25         |  | First Amendment dated March 16, 2007 to Employment Agreement dated as of October 20, 2005 by and between Aries Ventures Inc. and Christopher Reinhard*                                                                                                           |  | Exhibit 10.38 of our Quarterly Report on Form 10-Q for the quarter ended March 31, 2007, filed with the commission on May 15, 2007.        
|              |  |                                                                                                                                                                                                                                                                 
|10.26         |  | First Amendment dated March 16, 2007 to Employment Agreement dated as of October 20, 2005 by and between Aries Ventures Inc. and Tyler Dylan*                                                                                                                    |  | Exhibit 10.39 of our Quarterly Report on Form 10-Q for the quarter ended March 31, 2007, filed with the commission on May 15, 2007.        
|              |  |                                                                                                                                                                                                                                                                 
|10.27         |  | Form of Warrant issued to Life Sciences Capital LLC                                                                                                                                                                                                              |  | Exhibit 10.42 of our Quarterly Report on Form 10-Q for the quarter ended September 30, 2007, filed with the commission on November 14, 2007
|              |  |                                                                                                                                                                                                                                                                 
|10.28         |  | Office Lease by and between Paseo Del Mar CA LLC and Cardium Therapeutics, Inc., effective as of November 19, 2007                                                                                                                                               |  | Exhibit 10.43 of our Quarterly Report on Form 10-Q for the quarter ended September 30, 2007, filed with the commission on November 14, 2007
|              |  |                                                                                                                                                                                                                                                                 
|10.29         |  | Form of Securities Purchase Agreement dated January 30, 2008, by and between Cardium Therapeutics, Inc. and each purchaser in the January 2008 registered direct offering (an agreement on
substantially this form was signed by each purchaser in the offering) |  | Exhibit 10.1 of our Current Report on Form 8-K dated January 30, 2008, filed with the commission on January 31, 2008                       
|              |  |                                                                                                                                                                                                                                                                 
|10.30         |  | Form of Securities Purchase Agreement dated June 27, 2008, by and between Cardium Therapeutics, Inc. and each purchaser in the June 2008 registered direct offering (an agreement on substantially
this form was signed by each purchaser in the offering)       |  | Exhibit 10.1 of our Current Report on Form 8-K dated June 27, 2008, filed with the commission on June 30, 2008                             
|              |  |                                                                                                                                                                                                                                                                 
|10.31         |  | Form of Securities Purchase Agreement dated July 18, 2008, by and between Cardium Therapeutics, Inc. and each purchaser in the July 2008 registered direct offering (an agreement on substantially
this form was signed by each purchaser in the offering)       |  | Exhibit 10.1 of our Current Report on Form 8-K dated July 18, 2008, filed with the commission on July 21, 2008                             
|              |  |                                                                                                                                                                                                                                                                 
|10.32         |  | Placement Agent Agreement dated July 17, 2008, by and between Cardium Therapeutics, Inc. and Empire Asset Management Company                                                                                                                                     |  | Exhibit 10.2 of our Current Report on Form 8-K dated July 18, 2008, filed with the commission on July 21, 2008                             
|              |  |                                                                                                                                                                                                                                                                 
|31.1          |  | Rule 13a-14(a)/15d-14(a) Certification of Chief Executive Officer                                                                                                                                                                                                |  | Filed herewith                                                                                                                             
|              |  |                                                                                                                                                                                                                                                                 
|31.2          |  | Rule 13a-14(a)/15d-14(a) Certification of Chief Financial Officer                                                                                                                                                                                                |  | Filed herewith                                                                                                                             
|              |  |                                                                                                                                                                                                                                                                 
|32            |  | Section 1350 Certification                                                                                                                                                                                                                                       |  | Filed herewith                                                                                                                             



|* | Indicates management contract or compensatory plan or arrangement.
|- | ------------------------------------------------------------------



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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, Cardium Therapeutics, Inc., the registrant, has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

Date: November 10, 2008



CARDIUM THERAPEUTICS, INC.By:

/s/ Dennis M. MulroyDennis M. Mulroy, Chief Financial Officer


Mr. Mulroy is the principal financial officer of Cardium Therapeutics, Inc. and has been duly
authorized to sign on its behalf.



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