Prepared by R.R. Donnelley Financial -- EX-4.1




 Exhibit 4.1 
  






 
 SUBJECT TO THE CANADA BUSINESS CORPORATIONS ACT 
XENON PHARMACEUTICALS INC 
NUMBER 
GC4315495 
SHARES 
*1234567890************* 
**12345678901************ 
***12345678901*********** 
****12345678901********** 
*****12345678901********* 
This Certifies That 
* PROOF * GC4315495 * CA98420N1050 * 12345678901 FULLY PAID AND NON-ASSESSABLE COMMON SHARES XENON PHARMACEUTICALS INC. * XENON PHARMACEUTICALS INC. * PROOF * GC4315495 *
CA98420N1050 * 12345678901 FULLY PAID AND NON-ASSESSABLE COMMON SHARES XENON PHARMACEUTICALS INC. * XENON PHARMACEUTICALS INC. * PROOF * GC4315495 * CA98420N1050 * 12345678901 FULLY PAID AND NON-ASSESSABLE COMMON SHARES XENON PHARMACEUTICALS INC. *
XENON PHARMACEUTICALS INC. * PROOF * GC4315495 * CA98420N1050 * 12345678901 FULLY PAID AND NON-ASSESSABLE COMMON SHARES XENON PHARMACEUTICALS INC. * XENON PHARMACEUTICALS INC. * PROOF * GC4315495 * CA98420N1050 * 12345678901 FULLY PAID AND
NON-ASSESSABLE COMMON SHARES XENON PHARMACEUTICALS INC. * XENON PHARMACEUTICALS INC. * PROOF * GC4315495 * CA98420N1050 * 12345678901 FULLY PAID AND NON-ASSESSABLE COMMON SHARES XENON PHARMACEUTICALS INC. * XENON PHARMACEUTICALS INC. * PROOF *
GC4315495 * CA98420N1050 * 12345678901 FULLY PAID AND NON-ASSESSABLE COMMON SHARES XENON PHARMACEUTICALS INC. * XENON PHARMACEUTICALS INC. * PROOF * GC4315495 * CA98420N1050 * 12345678901 FULLY PAID AND NON-ASSESSABLE COMMON SHARES XENON
PHARMACEUTICALS INC. * XENON PHARMACEUTICALS INC. * PROOF * GC4315495 * CA98420N1050 * 12345678901 FULLY PAID AND NON-ASSESSABLE COM 
Is The Registered Holder Of

* PROOF * GC4315495 * CA98420N1050 * 12345678901 FULLY PAID AND NON-ASSESSABLE COMMON SHARES XENON PHARMACEUTICALS INC. * XENON PHARMACEUTICALS INC. * PROOF *
GC4315495 * CA98420N1050 * 12345678901 FULLY PAID AND NON-ASSESSABLE COMMON SHARES XENON PHARMACEUTICALS INC. * XENON PHARMACEUTICALS INC. * PROOF * GC4315495 * CA98420N1050 * 12345678901 FULLY PAID AND NON-ASSESSABL 
ISIN: CA98420N1050 
CUSIP: 98420N105 
FULLY PAID AND NON-ASSESSABLE COMMON SHARES WITHOUT NOMINAL OR PAR VALUE 
XENON PHARMACEUTICALS
INC. 
transferable only on the books of the Corporation by the registered holder hereof in person or by Attorney duly authorized in writing upon surrender of this
certificate properly endorsed. 
This certificate is not valid until countersigned and registered by the Registrar and Transfer Agent duly authorized by the
Corporation. 
IN WITNESS WHEREOF the corporation has caused this Certificate to be signed by the facsimile signature of its duly authorized officers. 
Chief Financial Officer 
General Counsel and Corporate Secretary 
The shares represented by this certificate are transferable at the offices CST Trust Company in Vancouver, British Columbia and Toronto, Ontario. 
DATED: OCTOBER 03, 2014 
COUNTERSIGNED AND REGISTERED CST TRUST COMPANY 
TRANSFER AGENT AND REGISTRAR 
BY: 
Authorized Signature 
VANCOUVER 
TORONTO 
Printed by DATA BUSINESS FORMS 
8913001 0 G PROOF – 00063815 SECURITY INSTRUCTIONS ON REVERSE VOIR LES INSTRUCTIONS DE SÉCURITÉ AU VERSO 
999999999 
G4215281 
4315495 








 




 
 SECURITY INSTRUCTIONS - INSTRUCTIONS DE SÉCURITÉ 
THIS IS WATERMARKED PAPER, DO NOT ACCEPT WITHOUT NOTING WATERMARK. HOLD TO LIGHT TO VERIFY WATERMARK. PAPIER FILIGRANE, NE PAS ACCEPTER SANS VÉRIFIER LA PRÉSENCE DU
FILIGRANE. POUR CE FAIRE, PLACER À LA LUMIÈRE. 
For value received, the undersigned hereby sell(s), assign(s) and transfer(s) unto 
(Print name(s) of person(s) to whom the securities are being transferred and the address for the register) 
shares 
(number of shares if blank, deemed to be all) 
of the Corporation represented by this certificate, and hereby irrevocably constitutes 
and
appoints the attorney of the undersigned to 
transfer the said securities with full power of substitution in this matter: 
Dated 
Signature Guarantee(s)* Transferor(s) Signature(s)* 
(the transfer cannot be processed without acceptable guarantees of all signatures) 
*For
transfers signed by the registered holder(s), their signatures(s) must correspond with the name(s) on the certificate in every particular, without changes. 
In
Canada and the US: a Medallion Guarantee obtained from a member of an acceptable Medallion Guarantee Program (STAMP, SEMP or MSP). Many banks, credit unions and broker dealers are members of a Medallion Guarantee Program. The guarantor must affix a
stamp in the space above bearing the actual words “Medallion Guaranteed”. 
In Canada: a Signature Guarantee obtained from a major Canadian Schedule I bank
that is not a member of a Medallion Guarantee Program. The guarantor must affix a stamp in the space above bearing the actual words “Signature Guaranteed”.

Outside Canada and the US: holders must obtain a guarantee from a local financial institution that has a corresponding affiliate in Canada or the US that is a
member of an acceptable Medallion Guarantee Program. The corresponding affiliate must over-guarantee the guarantee provided by the local financial institution.