<PAGE>

                                                                    EXHIBIT 10.1

                               Integ Incorporated

                              Consulting Agreement

This Agreement is made effective the 3rd day of April, 2000 by and between Integ
Incorporated (Integ), a Minnesota corporation, whose principal place of business
is 2800 Patton Road, St. Paul, MN 55113, and Mark B. Knudson, Ph.D. In
consideration of the mutual covenants and promises set forth herein, the parties
hereby agree as follows:

     1.   Engagement Area: Integ engages Mark B. Knudson, Ph.D. as a consultant
          for Integ in the area of management, training, technical expertise and
          advisory services.

     2.   Term: Unless terminated as hereafter provided, this Agreement shall
          begin on April 3, 2000 and end on April 2, 2003. The parties may
          negotiate one or more renewals of this Agreement.

     3.   Duties: Duties will be assigned by Integ and will involve consulting
          in the area of technical expertise and advisory services.

     4.   Compensation: Integ shall pay Mark B. Knudson, Ph.D. $6,750.00 per
          month in arrears for consulting services rendered in pursuit of this
          Agreement. Integ will reimburse Mark B. Knudson, Ph.D. for incidental
          expenses incurred in performing this Agreement, but such expenses
          shall not exceed $100.00 per month without Integ's prior written
          consent. Travel expenses must be approved in advance by Integ. Mark B.
          Knudson, Ph.D. shall provide Integ with appropriate documentation for
          tax purposes for all expenses paid by Integ.

     5.   Termination: Not withstanding any contrary provision contained
          elsewhere in this Agreement, this Agreement and the rights and
          obligations of Integ and Mark B. Knutson, Ph.D. hereunder (other than
          the rights and obligations of the parties under Section 7 or 9) shall
          be terminated upon the occurrence of any of the following events:

          a)   90 days after Mark B. Knudson, Ph.D.'s death; or

          b)   90 days after Mark B. Knudson, Ph.D. becomes disabled so that he
               is unable to render his normal services under this Agreement for
               a continuous period of thirty (30) days; or
<PAGE>

          c)   Immediately in the event that Mark B. Knudson, Ph.D. is convicted
               of any crime (excluding traffic violations or other minor
               offenses), or engages in any activities that constitute a
               material violation of normal standards of business ethics; or

          d)   Immediately in the event that Mark B. Knudson, Ph.D. willfully
               refuses to comply with or implement reasonable policies and work
               direction established by Integ; or

          e)   Upon fifteen (15) days prior written notice to Mark B. Knudson,
               Ph.D., if Mark B. Knudson, Ph.D. has failed in any material
               respect to perform his responsibilities hereunder and such
               default is not cured within such fifteen (15) day period.

          In the event this Agreement is terminated pursuant to this Section 5
          prior to the expiration of the term hereof, Mark B. Knudson, Ph.D.
          shall be entitled to receive his monthly consulting fee through the
          date of termination, but all other rights to receive consulting fees
          shall terminate on such date.

     6.   Status and Authority: In rendering services pursuant to this
          Agreement, Mark B. Knudson, Ph.D. shall be acting as an independent
          contractor and not as an employee or agent of Integ. As an independent
          contractor, Mark B. Knudson, Ph.D. shall have no authority, express or
          implied, to commit or obligate Integ in any manner whatsoever, except
          as specifically authorized from time to time in writing by an
          authorized representative of Integ, which authorization may be general
          or specific. Nothing contained in this Agreement shall be construed or
          applied to create a partnership. Mark B. Knudson, Ph.D. shall be
          responsible for the payment of all federal, state or local taxes
          payable with respect to all amounts paid to Mark B. Knudson, Ph.D.
          under this Agreement; provided, however, that if Integ is determined
          to be liable for the collection and/or remittance of any such taxes,
          Mark B. Knudson, Ph.D. shall immediately reimburse Integ for all such
          payments made by Integ.

     7.   Confidential Information: Because of the confidential nature of the
          information which will be disclosed to Mark B. Knudson, Ph.D. under
          this Agreement, Mark B. Knudson, Ph.D. will not, except as authorized
          by Integ, disclose such confidential information to any other third
          party or company. The obligation of confidentiality shall not be
          applicable with respect to such information which: (A) was known to
          Mark B. Knudson, Ph.D. prior to disclosure, (B) is or becomes known to
          the public by general publication without violation of this Agreement,
          (C) is given to Mark B. Knudson, Ph.D. by a third party having a right
          to do so, or (D) is independently developed by Mark B. Knudson, Ph.D.
          without the use of information supplied by Integ under this Agreement.

     8.   Exclusivity: Because of the confidential nature of the information
          which will be disclosed to Mark B. Knudson, Ph.D. under this
          Agreement, Mark B. Knudson,
<PAGE>

          Ph.D. will not do any other consulting work in the area of Integ's
          interests without prior approval by Integ.

     9.   Ownership of Inventions and Patents: If any patentable inventions
          result from performance of this Agreement, all rights under any
          patents that may issue on those inventions shall belong exclusively to
          Integ. Mark B. Knudson, Ph.D. agrees to assign all such inventions to
          Integ without further payment from Integ. Mark B. Knudson, Ph.D. also
          agrees that, upon Integ's request and at Integ's expense, he would
          provide reasonable assistance to Integ in prosecuting patents covering
          those inventions.

     10.  Notices: All notices required or permitted by this Agreement shall be
          in writing and shall be delivered in person or sent by certified or
          registered mail, return receipt required, postage paid as follows:

                  President
                  Integ Incorporated
                  2800 Patton Road
                  St. Paul, MN 55113

                  Mark B. Knudson, Ph.D.
                  1309 West Royal Oaks Drive
                  Shoreview, MN 55126

          or to other's address as either party may designate. All mailing
          notices shall be deemed effective upon depositing in the mail.

     11.  Waiver: The waiver of either party of a breach of any provision of
          this Agreement shall not operate as or be construed as a continuing
          waiver or as a consent to or waiver of such subsequent breach.

     12.  Modification: This Agreement may only be modified in writing signed by
          both parties.

     13.  Nonassignable: Since the services to be provided under this Agreement
          are personal, all duties to be executed by Mark B. Knudson, Ph.D.
          shall be performed by Mark B. Knudson, Ph.D. and may not be assigned
          or delegated without written consent of Integ.

     14.  Entire Agreement: This Agreement constitutes the entire Agreement
          between the parties with respect to the subject matter hereof and
          supersedes all previous agreements and understandings rather oral or
          written between the parties with respect to the subject hereof.
<PAGE>

     15.  Governing Law: This Agreement shall be governed by the laws of the
          State of Minnesota. In witness thereof, the parties have set forth
          their hand hither and to on the date indicated below.


Integ Incorporated                          Mark B. Knudson, Ph.D.

By:      _________________________          By:      _________________________

Title:   _________________________          Title:   _________________________

Date:    _________________________          Date:    _________________________