[Federal Register Volume 75, Number 165 (Thursday, August 26, 2010)]
[Notices]
[Pages 52535-52536]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2010-21298]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-266]


Availability of Draft Toxicological Profile

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR),

[[Page 52536]]

Department of Health and Human Services (DHHS).

ACTION: Notice of availability.

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SUMMARY: This notice announces, for review and comment, the 
availability of one new draft toxicological profile on unregulated 
hazardous substances that was prepared for the Department of Defense 
(DOD). All toxicological profiles issued as ``Drafts for Public 
Comment'' represent ATSDR's best efforts to provide important 
toxicological information on priority hazardous substances. We are 
seeking public comments and additional information or reports on 
studies about the health effects of royal demolition explosive (RDX), 
chemical name hexahydro-1,3,5-trinitro-1,3,5-triazine, also known as 
cyclonite, for review and potential inclusion in the profile. ATSDR 
remains committed to providing a public comment period for these 
documents as a means to best serve public health and our stakeholders.

DATES: To be considered, comments on this draft toxicological profile 
must be received not later than November 19th, 2010. Comments received 
after the close of the public comment period will be considered at the 
discretion of ATSDR, based upon what is deemed to be in the best 
interest of the general public.

ADDRESSES: Requests for printed copies of the draft toxicological 
profile should be sent via e-mail to <a href="/cdn-cgi/l/email-protection#6a090e0903040c052a090e09440d051c"><span class="__cf_email__" data-cfemail="aecdcacdc7c0c8c1eecdcacd80c9c1d8">[email protected]</span></a>, or to Ms. Olga 
Dawkins, Division of Toxicology and Environmental Medicine, Agency for 
Toxic Substances and Disease Registry, Mailstop F-62, 1600 Clifton 
Road, NE., Atlanta, Georgia 30333. Electronic access to this document 
is also available at the ATSDR Web site: http://www.atsdr.cdc.gov/toxpro2.html.
    Written comments and other data submitted in response to this 
notice and to the draft RDX toxicological profile should bear the 
docket control number ATSDR-XXX. Send one copy of all comments and 
three copies of all supporting documents to the attention of Ms. 
Nickolette Roney, Division of Toxicology and Environmental Medicine, 
Agency for Toxic Substances and Disease Registry, Mailstop F-62, 1600 
Clifton Road, NE., Atlanta, Georgia 30333, by the end of the comment 
period. Electronic comments may be sent via e-mail to: 
<a href="/cdn-cgi/l/email-protection#96e2e6e6e3f4fafff5f5f9fbfbf3f8e2e5d6f5f2f5b8f1f9e0"><span class="__cf_email__" data-cfemail="83f7f3f3f6e1efeae0e0eceeeee6edf7f0c3e0e7e0ade4ecf5">[email protected]</span></a>. Please include RDX in the subject line of the 
e-mail. Because all public comments regarding ATSDR toxicological 
profiles are available for public inspection, no confidential business 
information or other confidential information should be submitted in 
response to this notice.

FOR FURTHER INFORMATION CONTACT: Ms. Olga Dawkins, Division of 
Toxicology and Environmental Medicine, Agency for Toxic Substances and 
Disease Registry, Mailstop F-62, 1600 Clifton Road, NE., Atlanta, 
Georgia 30333, telephone (770) 488-3315. Electronic access to this 
document is also available at the ATSDR Web site: http://www.atsdr.cdc.gov/toxpro2.html. Comments and other data submitted in 
response to this notice and the draft toxicological profile should bear 
the docket control number ATSDR-266.

SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization 
Act (SARA) of 1986 (Pub. L. 99-499) amended the Comprehensive 
Environmental Response, Compensation, and Liability Act (CERCLA or 
Superfund). Section 211 of SARA also amended Title 10 of the U.S. Code, 
creating the Defense Environmental Restoration Program. Section 2704(a) 
of Title 10 of the U.S. Code directs the Secretary of Defense to notify 
the Secretary of DHHS of not less than 25 of the most commonly found 
unregulated hazardous substances at defense facilities. The Secretary 
of DHHS is to prepare toxicological profiles of these substances. Each 
profile is to include an examination, summary, and interpretation of 
available toxicological information and epidemiologic evaluations. This 
information is used to ascertain the level of significant human 
exposure for the substance and the associated health effects. The 
toxicological profile includes a determination of whether adequate 
information on the health effects of each substance is available or is 
in the process of being developed. When adequate information is not 
available, ATSDR, in cooperation with the National Toxicology Program 
(NTP), may plan a program of research designed to determine these 
health effects.
    Although a number of key studies for this substance were identified 
and evaluated during the draft profile development process, this 
Federal Register notice seeks to solicit any additional studies, 
particularly unpublished data and ongoing studies. These studies will 
be evaluated for possible addition to the profile now or in the future.
    The draft toxicological profile will be made available to the 
public on or about August 20, 2010.

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                    Hazardous substance                        CAS No.
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RDX........................................................     121-82-4
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    Dated: August 20, 2010.
Kenneth Rose,
Director, Office of Policy, Planning, and Evaluation, National Center 
for Environmental Health/Agency for Toxic Substances and Disease 
Registry.
[FR Doc. 2010-21298 Filed 8-25-10; 8:45 am]
BILLING CODE 4163-70-P


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