53304 Federal Register / Vol. 75, No. 168 / Tuesday, August 31, 2010 / Notices 

1Chang, H.S., Anway, M.D., Rekow, S.S., & 

Skinner, M.K. ‘‘Transgenerational epigenetic 

imprinting of the male germline by endocrine 

disruption exposure during gonadal sex 

determination.’’ Endocrinology 147(12):5524–5541; 

hereafter referred to as the ‘‘Endocrinology paper.’’ 

and falsifying data in Figure 3 of a paper 

published in Endocrinology.1

Specifically, PHS found that: 

• Respondent, by not conducting any 

of the claimed bisulfite sequencing, 

fabricated the methylation status of CpG 

sites in eight candidate genes identified 

in both Figures 3 and 4 as No. 11, No. 

12, No. 13, No. 14, 15, No. 22, No. 26, 

No. 31, and No. 19, to support the 

hypothesis that the environmental 

compound, vinclozolin, induces a 

permanent alteration in the epigenetic 

reprogramming of the germline that 

promotes transgenerational disease 

states. 

• Respondent, by conducting only a 

small fraction of the claimed bisulfite 

sequencing, and falsifying the results 

obtained, falsified the methylation 

status of CpG sites in eight additional 

candidate genes, identified in Figures 3 

and 4 as No. 2, 3, 24, No. 5, 6, 9, No. 

8, No. 16, No. 17, 18, No. 27, 28, No. 29, 

and No. 33. 

Dr. Chang has entered into a Voluntary 

Settlement Agreement in which he has 

voluntarily agreed, for a period of three 

(3) years, beginning on July 21, 2010: 

(1) To exclude himself from serving in 

any advisory capacity to PHS, including 

but not limited to service on any PHS 

advisory committee, board, and/or peer 

review committee, or as a consultant; 

(2) that any institution that submits an 

application for PHS support for a 

research project on which the 

Respondent’s participation is proposed 

or that uses him in any capacity on 

PHS-support research, or that submits a 

report of PHS-funded research in which 

the Respondent is involved, must 

concurrently submit a plan for 

supervision of the Respondent’s duties 

to the funding agency for approval. The 

supervisory plan must be designed to 

ensure the scientific integrity of the 

Respondent’s research contribution 

while applying for or conducting PHSsupported research. Respondent agrees 

to ensure that a copy of the supervisory 

plan is submitted to ORI by the 

institution for ORI approval. 

Respondent agrees not to participate in 

any PHS-supported research until such 

a supervisory plan is submitted to ORI. 

FOR FURTHER INFORMATION CONTACT: 

Director, Division of Investigative 

Oversight, Office of Research Integrity, 

1101 Wootton Parkway, Suite 750, 

Rockville, MD 20852, (240) 453–8800. 

John Dahlberg, 

Director, Division of Investigative Oversight, 

Office of Research Integrity. 

[FR Doc. 2010–21579 Filed 8–30–10; 8:45 am] 

BILLING CODE 4150–31–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Office of the Secretary 

Office of the Assistant Secretary for 

Health; Statement of Organization, 

Functions, and Delegations of 

Authority 

Part A, Office of the Secretary, 

Statement of Organizations, Functions 

and Delegations of Authority for the 

Department of Health and Human 

Services (HHS) is being amended at 

Chapter AA, ‘‘Immediate Office of the 

Secretary,’’ which was last amended at 

75 FR 20364–65, dated April 19, 2010, 

and at Chapter AC, ‘‘Office of Public 

Health and Science (OPHS),’’ which was 

last amended at 72 FR 58095–96, dated 

October 12, 2007. This amendment will 

accomplish two tasks: (1) In Chapter 

AC, revise the title of the office headed 

by the Assistant Secretary for Health 

(ASH) from the ‘‘Office of Public Health 

and Science’’ to the ‘‘Office of the 

Assistant Secretary for Health,’’ and; (2) 

add information about a new office 

reporting to the Assistant Secretary for 

Health (ASH), the ‘‘Office of Adolescent 

Health,’’ established in section 1708 of 

the Public Health Service (PHS) Act (42 

U.S.C. 300u–7), and most recently 

addressed in the December 8, 2009, 

Conference Report (House Report 111– 

366) accompanying the Consolidated 

Appropriations Act, 2010 (Pub. L. 111– 

117). The changes are as follows: 

A. Under Part A, Chapter AA, Section 

AA.10 Organization, replace the ‘‘Office 

of Public Health and Science (AC)’’ with 

the ‘‘Office of the Assistant Secretary for 

Health (AC).’’ 

B. Under Part A generally and Part A, 

Chapter AC, replace all references to the 

‘‘Office of Public Health and Science’’ 

with the ‘‘Office of the Assistant 

Secretary for Health’’ and all references 

to ‘‘OPHS’’ with ‘‘OASH.’’ 

C. Under Part A, Chapter AC, Section 

AC.10 Organization, insert ‘‘M. Office of 

Adolescent Health (ACR)’’ immediately 

after ‘‘L. Office of Commissioned Corps 

Force Management (ACQ).’’ 

D. Under Part A, Chapter AC, Section 

AC.20 Functions, insert the following 

text immediately after item, ‘‘L. Office of 

Commissioned Corps Force 

Management (ACQ)’’: 

M. Office of Adolescent Health (ACR) 

Section ACR.00 Mission. The Director 

of the Office of Adolescent Health 

(OAH) is the principal advisor to the 

Assistant Secretary for Health (ASH) on 

health-related policy and program 

issues related to adolescents. These 

issues cut across Health and Human 

Services (HHS) components which 

provide research, services, prevention, 

promotion, treatment, training, 

education, and information 

dissemination related to adolescent 

health. OAH is responsible for 

implementing activities authorized by 

section 1708 of the Public Health 

Service (PHS) Act. 

Section ACR.10 Organization. The 

Office of Adolescent Health is headed 

by a Director who reports to the 

Assistant Secretary for Health and is 

includes the following components: 

A. Immediate Office of the Director 

(ACR) 

B. Division of Program Development 

and Operations (ACR1) 

C. Division of Policy, Planning, and 

Communications (ACR2) 

Section ACR.20 Functions 

1. Immediate Office of the Director 

(ACR). The Immediate Office of the 

Director (IOD) plans and directs 

financial management and policy 

development, including budget 

formulation and execution. The IOD 

also oversees legislative activities 

related to adolescent health, acts as a 

liaison on personnel management to the 

Office of the Assistant Secretary for 

Health (OASH) and the Program 

Support Center, and coordinates 

correspondence control and executive 

secretariat functions for OAH. The IOD 

also manages the day-to-day operations 

of OAH, plans, coordinates, monitors, 

and evaluates OAH grants and contracts, 

and ensures the appropriate exercise of 

delegated authorities and 

responsibilities. 

2. Division of Program Development 

and Operations (ACR1). The Division of 

Program Development and Operations 

(DPDO) advises the OAH Director on the 

development of new programs and 

policies, oversees the implementation 

and administration of competitive 

grants and cooperative agreements, 

monitors grantee activities, evaluates 

the focus and impact of ongoing 

programs, prepares analytical reports on 

program trends, provides training and 

technical assistance for grant programs, 

and assesses performance of grantee 

operations. The Division manages the 

development of funding announcements 

and contract scopes of work and the 

review and award of program grants, 


srobinson on DSKHWCL6B1PROD with NOTICES
Federal Register / Vol. 75, No. 168 / Tuesday, August 31, 2010 / Notices 53305 

cooperative agreements, and contracts. 

The Division also provides for training 

of health professionals who work with 

adolescents, particularly nurse 

practitioners, physician assistants, and 

social workers. 

3. Division of Policy, Planning, and 

Communications (ACR2). The Division 

of Policy, Planning, and 

Communications (DPPC) is the primary 

information source on adolescent health 

programs of OAH. The Division: advises 

the OAH Director on policy issues; 

manages information, education and 

awareness activities and media and 

press relations; develops and 

coordinates strategic plans and special 

initiatives; oversees public health 

information and performance 

measurement; and coordinates and 

promotes OAH programs and policies. 

DPPC oversees and directs the OAH’s 

communication programs, consistent 

with the policies of the HHS Assistant 

Secretary for Public Affairs. This 

Division also coordinates, develops, 

researches, and prepares briefing 

materials on adolescent health for the 

OAH Director and other HHS offices. 

E. Under Part A, Chapter AC, Section 

AC.10 Organization, replace all 

references to the ‘‘Office of the 

President’s Council on Physical Fitness 

and Sports (ACE)’’ with the ‘‘Office of 

the President’s Council on Fitness, 

Sports and Nutrition (ACE)’’ and all 

references to the ‘‘President’s Council on 

Physical Fitness and Sports’’ with the 

‘‘President’s Council on Fitness, Sports 

and Nutrition.’’ 

F. Under Part A, Chapter AC, Section 

AC.20 Functions, Paragraph A, ‘‘The 

Immediate Office (ACA),’’ insert the 

following after ‘‘(18)’’: 

(19) leads and coordinates public 

health activities that addresses health 

disparities related to sexual orientation. 

Dated: July 29, 2010. 

Kathleen Sebelius, 

Secretary. 

[FR Doc. 2010–21695 Filed 8–30–10; 8:45 am] 

BILLING CODE 4150–28–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Agency for Healthcare Research and 

Quality 

Agency Information Collection 

Activities: Proposed Collection; 

Comment Request 

AGENCY: Agency for Healthcare Research 

and Quality, HHS. 

ACTION: Notice. 

SUMMARY: This notice announces the 

intention of the Agency for Healthcare 

Research and Quality (AHRQ) to request 

that the Office of Management and 

Budget (OMB) approve the proposed 

information collection project: ‘‘AHRQ 

Grants Reporting System (GRS).’’ In 

accordance with the Paperwork 

Reduction Act, 44 U.S.C. 3501–3520, 

AHRQ invites the public to comment on 

this proposed information collection. 

DATES: Comments on this notice must be 

received by November 1, 2010. 

ADDRESSES: Written comments should 

be submitted to: Doris Lefkowitz, 

Reports Clearance Officer, AHRQ, by 

e-mail at 

doris.lefkowitz@AHRQ.hhs.gov. 

Copies of the proposed collection 

plans, data collection instruments, and 

specific details on the estimated burden 

can be obtained from the AHRQ Reports 

Clearance Officer. 

FOR FURTHER INFORMATION CONTACT: 

Doris Lefkowitz, AHRQ Reports 

Clearance Officer, (301) 427–1477, or by 

e-mail at 

doris.lefkowitz@AHRQ.hhs.gov. 

SUPPLEMENTARY INFORMATION: 

Proposed Project 

AHRQ Grants Reporting System (GRS) 

AHRQ seeks to renew the Agency’s 

Grants Reporting System (GRS), a 

systematic method for its grantees to 

report project progress and important 

preliminary findings for grants funded 

by the Agency. This system was first 

approved by OMB on November 10th, 

2004 (OMB Control Number 0935– 

0122). The system addressed the 

shortfalls in the previous reporting 

process and established a consistent and 

comprehensive grants reporting solution 

for AHRQ. The GRS provides a 

centralized repository of grants research 

progress and additional information that 

can be used to support initiatives within 

the Agency. This includes future 

research planning and support to 

administration activities such as 

performance monitoring, budgeting, 

knowledge transfer as well as strategic 

planning. 

The overall intent of the GRS project 

is to establish and document a 

systematic process that provides 

grantees with the ability to submit 

critical information in a timely manner 

throughout the lifecycle of a grant. In 

addition, the GRS project includes an 

infrastructure that is scalable and 

flexible to support information 

exchange throughout the Agency. 

The GRS is based on a review of the 

previous processes that supported the 

solicitation and submission of data 

associated with patient safety grants. 

Following this review, a recommended 

process was prepared and presented to 

AHRQ stakeholders. The project team 

developed an initial system that 

addresses the immediate needs of the 

stakeholder community. 

The project team, in conjunction with 

the stakeholder community will 

establish follow-on activities which will 

expand the capabilities of the initial 

system to meet the longer term goals of 

the project as directed by the executive 

management team of the agency. The 

specific activities that were 

accomplished in the short term and 

those established for the longer term are 

outlined below. 

Short-Term Objectives 

The following initial objectives for the 

GRS project have been: 

Æ Establish and document a 

systematic process which supports the 

voluntary reporting of project progress 

and important preliminary findings 

associated with patient safety research 

grants. 

Æ Collect, document, and prioritize 

the long-term objectives of the GRS. 

Æ Establish an infrastructure that 

satisfies the short-term objectives of the 

project and can be leveraged to meet the 

long-term objectives and anticipated 

expansion. 

Æ Establish an automated userfriendly resource that will be used by 

grantees, regardless of mechanism, for 

reporting to AHRQ. 

Æ Establish an automated userfriendly resource that will be utilized by 

Agency staff for preparing, distributing, 

and reviewing reporting requests to 

patient safety grantees. 

Æ Ensure that the necessary security 

requirements are established and 

implemented in order to maintain the 

intellectual property or publication 

rights of grantees. 

Æ Establish a solution that is 

consistent with the AHRQ enterprise 

architecture model and aligned with 

AHRQ systems development standards. 

Long-Term Objectives 

The AHRQ project team will continue 

to enhance the GRS to establish a single, 

common reporting system for research 

related activities by: 

Æ Enhancing the initial system as 

necessary to accommodate features not 

addressed by the short-term solution. 

Æ Modifying the short-term solution 

to address new requirements and refine 

existing functionality for use across the 

agency for other programs and 

mechanisms. 

Æ Expanding the deployment of the 

system to accommodate additional 


srobinson on DSKHWCL6B1PROD with NOTICES